ZNF318

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K36 demethylation (GO:0070544)8.64881486
2histone H3-K9 demethylation (GO:0033169)6.15027504
3synapsis (GO:0007129)6.10231861
4piRNA metabolic process (GO:0034587)5.61981955
5chromosome organization involved in meiosis (GO:0070192)5.45987216
6DNA methylation involved in gamete generation (GO:0043046)5.43959982
7mitotic sister chromatid cohesion (GO:0007064)5.10268351
8synaptonemal complex assembly (GO:0007130)5.03538562
9DNA synthesis involved in DNA repair (GO:0000731)5.00434331
10regulation of NFAT protein import into nucleus (GO:0051532)4.98487159
11sister chromatid cohesion (GO:0007062)4.93892924
12regulation of histone H3-K9 methylation (GO:0051570)4.80446650
13regulation of RNA export from nucleus (GO:0046831)4.78639692
14histone lysine demethylation (GO:0070076)4.67218931
15nuclear pore complex assembly (GO:0051292)4.64685053
16male meiosis I (GO:0007141)4.62402596
17meiotic chromosome segregation (GO:0045132)4.59762963
18histone demethylation (GO:0016577)4.46872721
19male meiosis (GO:0007140)4.41542977
20B cell receptor signaling pathway (GO:0050853)4.41500779
21regulation of B cell receptor signaling pathway (GO:0050855)4.27044032
22synaptonemal complex organization (GO:0070193)4.21910587
23signal complex assembly (GO:0007172)4.19741109
24meiotic nuclear division (GO:0007126)4.16850181
25positive regulation of gene expression, epigenetic (GO:0045815)4.01250462
26protein demethylation (GO:0006482)3.97104098
27protein dealkylation (GO:0008214)3.97104098
28mitotic chromosome condensation (GO:0007076)3.96882475
29negative regulation of gene silencing (GO:0060969)3.90870935
30regulation of DNA endoreduplication (GO:0032875)3.86238608
31histone H4-K16 acetylation (GO:0043984)3.85030449
32regulation of nucleobase-containing compound transport (GO:0032239)3.83728677
33CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.80395187
34positive regulation of gamma-delta T cell activation (GO:0046645)3.76318534
35nuclear pore organization (GO:0006999)3.71056517
36interkinetic nuclear migration (GO:0022027)3.63522189
37negative regulation of histone methylation (GO:0031061)3.54846657
38meiosis I (GO:0007127)3.53753392
39regulation of chromatin silencing (GO:0031935)3.49849771
40DNA alkylation (GO:0006305)3.46968828
41DNA methylation (GO:0006306)3.46968828
42peptidyl-lysine trimethylation (GO:0018023)3.46880196
43peptidyl-lysine methylation (GO:0018022)3.38850640
44pore complex assembly (GO:0046931)3.37073517
45regulation of meiosis I (GO:0060631)3.33916044
46B cell homeostasis (GO:0001782)3.32212500
47histone H3-K4 trimethylation (GO:0080182)3.22700203
48regulation of histone methylation (GO:0031060)3.18348351
49regulation of histone H3-K27 methylation (GO:0061085)3.18085207
50glucocorticoid receptor signaling pathway (GO:0042921)3.17343327
51meiotic cell cycle process (GO:1903046)3.15896721
52gene silencing by RNA (GO:0031047)3.10572927
53positive regulation by symbiont of host defense response (GO:0052509)3.09208851
54modulation by symbiont of host defense response (GO:0052031)3.09208851
55modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.09208851
56modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.09208851
57positive regulation by organism of defense response of other organism involved in symbiotic interact3.09208851
58modulation by symbiont of host immune response (GO:0052553)3.09208851
59establishment of nucleus localization (GO:0040023)3.06614505
60histone H3-K4 methylation (GO:0051568)3.06085514
61positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.03921383
62histone lysine methylation (GO:0034968)3.01080748
63corticosteroid receptor signaling pathway (GO:0031958)2.97405320
64T cell lineage commitment (GO:0002360)2.96161315
65nucleus localization (GO:0051647)2.93215646
66monoubiquitinated protein deubiquitination (GO:0035520)2.92123926
67histone H4 acetylation (GO:0043967)2.90916001
68histone H4-K5 acetylation (GO:0043981)2.87939953
69histone H4-K8 acetylation (GO:0043982)2.87939953
70nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.82962764
71histone H3-K9 modification (GO:0061647)2.82701364
72negative thymic T cell selection (GO:0045060)2.81161621
73regulation of transcription from RNA polymerase I promoter (GO:0006356)2.78541765
74regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.78128956
75histone H4 deacetylation (GO:0070933)2.76991598
76histone H4-K12 acetylation (GO:0043983)2.76734710
77regulation of protein polyubiquitination (GO:1902914)2.76237265
78regulation of chromatin binding (GO:0035561)2.73373960
79regulation of gamma-delta T cell activation (GO:0046643)2.72426458
80positive regulation of mitotic sister chromatid separation (GO:1901970)2.71922574
81positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.71922574
82positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.71922574
83peptidyl-threonine phosphorylation (GO:0018107)2.70606430
84negative regulation of DNA repair (GO:0045738)2.64843812
85B cell proliferation (GO:0042100)2.64608444
86protein localization to chromosome (GO:0034502)2.62980934
87DNA packaging (GO:0006323)2.60607573
88positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.60473110
89positive regulation of B cell differentiation (GO:0045579)2.59031953
90cytoplasmic mRNA processing body assembly (GO:0033962)2.58749459
91reciprocal DNA recombination (GO:0035825)2.57952714
92reciprocal meiotic recombination (GO:0007131)2.57952714
93growth hormone receptor signaling pathway (GO:0060396)2.57659383
94negative T cell selection (GO:0043383)2.56636753
95positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.54940999
96positive regulation of humoral immune response (GO:0002922)2.54343384
97positive regulation of DNA-templated transcription, initiation (GO:2000144)2.54237790
98protein export from nucleus (GO:0006611)2.52796967
99positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.52200282
100phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.52078232

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.42995408
2EGR1_19374776_ChIP-ChIP_THP-1_Human5.03599217
3MYC_22102868_ChIP-Seq_BL_Human4.82019325
4VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human3.79289768
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.51443928
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.48881402
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.27757708
8CIITA_25753668_ChIP-Seq_RAJI_Human2.92587005
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.89729818
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.80105303
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.76509653
12KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.65241457
13VDR_21846776_ChIP-Seq_THP-1_Human2.56921992
14MAF_26560356_Chip-Seq_TH1_Human2.34855744
15KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.33991012
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.33388756
17NOTCH1_21737748_ChIP-Seq_TLL_Human2.27237243
18MYB_26560356_Chip-Seq_TH1_Human2.26886275
19FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.26224973
20E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.23425089
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.20314705
22TCF7_22412390_ChIP-Seq_EML_Mouse2.19515189
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.19009414
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.17575836
25MYB_26560356_Chip-Seq_TH2_Human2.05901346
26KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.05337470
27E2F1_21310950_ChIP-Seq_MCF-7_Human2.02112716
28PKCTHETA_26484144_Chip-Seq_BREAST_Human1.92794190
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.91989563
30E2F4_17652178_ChIP-ChIP_JURKAT_Human1.88534064
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.85865168
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.84504590
33MYB_21317192_ChIP-Seq_ERMYB_Mouse1.84164513
34TP63_19390658_ChIP-ChIP_HaCaT_Human1.83116394
35* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.79637320
36* RUNX_20019798_ChIP-Seq_JUKART_Human1.77135250
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.76710113
38MAF_26560356_Chip-Seq_TH2_Human1.75913298
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.74680194
40EZH2_22144423_ChIP-Seq_EOC_Human1.71795017
41CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.71570090
42UTX_26944678_Chip-Seq_JUKART_Human1.70880986
43CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.69126562
44NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67468524
45* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.64318415
46IRF8_27001747_Chip-Seq_BMDM_Mouse1.64061456
47DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.60284732
48KDM2B_26808549_Chip-Seq_DND41_Human1.59954361
49VDR_24763502_ChIP-Seq_THP-1_Human1.50914189
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.48698672
51GATA3_27048872_Chip-Seq_THYMUS_Human1.45712863
52BRD4_27068464_Chip-Seq_AML-cells_Mouse1.37826698
53KDM2B_26808549_Chip-Seq_JURKAT_Human1.35411259
54TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.34237761
55* SPI1_23547873_ChIP-Seq_NB4_Human1.31795516
56STAT4_19710469_ChIP-ChIP_TH1__Mouse1.29422304
57FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.27512238
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27277569
59DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24926370
60RUNX1_22412390_ChIP-Seq_EML_Mouse1.24020945
61VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.23668720
62TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23322683
63SCL_19346495_ChIP-Seq_HPC-7_Human1.18924571
64CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16313758
65MYCN_18555785_ChIP-Seq_MESCs_Mouse1.15231945
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12721975
67IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.11899103
68AR_21572438_ChIP-Seq_LNCaP_Human1.11828232
69KDM5A_27292631_Chip-Seq_BREAST_Human1.11224248
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.09833004
71TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05852249
72VDR_24787735_ChIP-Seq_THP-1_Human1.04770264
73SPI1_23127762_ChIP-Seq_K562_Human1.03295396
74YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99805202
75NCOR1_26117541_ChIP-Seq_K562_Human0.99330358
76NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99049768
77* FOXA2_19822575_ChIP-Seq_HepG2_Human0.98975427
78SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97962491
79PU_27001747_Chip-Seq_BMDM_Mouse0.93455733
80* TFEB_21752829_ChIP-Seq_HELA_Human0.92413386
81FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.91984901
82EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91833780
83SMRT_27268052_Chip-Seq_Bcells_Human0.89555419
84ZFP281_27345836_Chip-Seq_ESCs_Mouse0.89267964
85GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88387754
86PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88160462
87GATA1_22025678_ChIP-Seq_K562_Human0.86715850
88E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.86160404
89TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86154341
90CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85934525
91MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.85886490
92* GATA3_26560356_Chip-Seq_TH1_Human0.84604098
93PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83694534
94KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.82122089
95GATA2_22383799_ChIP-Seq_G1ME_Mouse0.81103441
96ETS1_22383799_ChIP-Seq_G1ME_Mouse0.80332300
97FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80173733
98Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.79696811
99MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.78985989
100* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78127154

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.06806456
2MP0008877_abnormal_DNA_methylation4.19977337
3MP0000569_abnormal_digit_pigmentation3.30042293
4MP0003763_abnormal_thymus_physiology3.04736498
5MP0000685_abnormal_immune_system2.90630364
6MP0002166_altered_tumor_susceptibility2.79471463
7MP0001800_abnormal_humoral_immune2.60751387
8MP0001835_abnormal_antigen_presentation2.49233610
9MP0002009_preneoplasia2.37917821
10MP0005671_abnormal_response_to2.35984991
11MP0010094_abnormal_chromosome_stability2.27837033
12MP0001790_abnormal_immune_system2.26325705
13MP0005387_immune_system_phenotype2.26325705
14MP0000015_abnormal_ear_pigmentation2.16130789
15MP0005451_abnormal_body_composition2.08565634
16MP0003183_abnormal_peptide_metabolism2.01738644
17MP0003172_abnormal_lysosome_physiology1.97373152
18MP0002396_abnormal_hematopoietic_system1.96811238
19MP0002398_abnormal_bone_marrow1.96005958
20MP0002210_abnormal_sex_determination1.92394274
21MP0005409_darkened_coat_color1.92060184
22MP0003077_abnormal_cell_cycle1.89616030
23MP0004808_abnormal_hematopoietic_stem1.88556749
24MP0005310_abnormal_salivary_gland1.85612154
25MP0003111_abnormal_nucleus_morphology1.80647289
26MP0002452_abnormal_antigen_presenting1.79515705
27MP0001348_abnormal_lacrimal_gland1.79101811
28MP0005645_abnormal_hypothalamus_physiol1.77170608
29MP0002723_abnormal_immune_serum1.75078270
30MP0000703_abnormal_thymus_morphology1.74912327
31MP0002006_tumorigenesis1.73749645
32MP0005000_abnormal_immune_tolerance1.72873112
33MP0003693_abnormal_embryo_hatching1.69777563
34MP0001873_stomach_inflammation1.68005784
35MP0002420_abnormal_adaptive_immunity1.65413731
36MP0005076_abnormal_cell_differentiation1.63626194
37MP0001819_abnormal_immune_cell1.61327245
38MP0001929_abnormal_gametogenesis1.59302366
39MP0003303_peritoneal_inflammation1.54507964
40MP0000716_abnormal_immune_system1.53520784
41MP0008058_abnormal_DNA_repair1.53488969
42MP0000689_abnormal_spleen_morphology1.46962907
43MP0003646_muscle_fatigue1.45531126
44MP0002722_abnormal_immune_system1.42609643
45MP0001145_abnormal_male_reproductive1.41037745
46MP0003698_abnormal_male_reproductive1.36585064
47MP0002429_abnormal_blood_cell1.27645063
48MP0003890_abnormal_embryonic-extraembry1.24675886
49MP0002138_abnormal_hepatobiliary_system1.24397618
50MP0001730_embryonic_growth_arrest1.22898800
51MP0003300_gastrointestinal_ulcer1.22111002
52MP0000371_diluted_coat_color1.19007057
53MP0000653_abnormal_sex_gland1.18092367
54MP0000350_abnormal_cell_proliferation1.17658286
55MP0008995_early_reproductive_senescence1.16535662
56MP0010307_abnormal_tumor_latency1.16291592
57MP0004381_abnormal_hair_follicle1.16115319
58MP0009333_abnormal_splenocyte_physiolog1.16069504
59MP0004233_abnormal_muscle_weight1.15648221
60MP0003436_decreased_susceptibility_to1.10154192
61MP0002405_respiratory_system_inflammati1.07298544
62MP0003091_abnormal_cell_migration1.07057174
63MP0005174_abnormal_tail_pigmentation1.00796870
64MP0002160_abnormal_reproductive_system0.99601383
65MP0005621_abnormal_cell_physiology0.99463275
66MP0000313_abnormal_cell_death0.97158769
67MP0001915_intracranial_hemorrhage0.96518034
68MP0008260_abnormal_autophagy0.96235158
69MP0003943_abnormal_hepatobiliary_system0.95824217
70MP0003984_embryonic_growth_retardation0.95743396
71MP0009115_abnormal_fat_cell0.95068630
72MP0001672_abnormal_embryogenesis/_devel0.93653999
73MP0005380_embryogenesis_phenotype0.93653999
74MP0008961_abnormal_basal_metabolism0.91230898
75MP0002019_abnormal_tumor_incidence0.90350159
76MP0002088_abnormal_embryonic_growth/wei0.90346938
77MP0000383_abnormal_hair_follicle0.89918141
78MP0005025_abnormal_response_to0.87251751
79MP0005389_reproductive_system_phenotype0.84339155
80MP0000427_abnormal_hair_cycle0.83740647
81MP0010678_abnormal_skin_adnexa0.83593199
82MP0002419_abnormal_innate_immunity0.82416892
83MP0001697_abnormal_embryo_size0.82072318
84MP0003699_abnormal_female_reproductive0.80812102
85MP0008007_abnormal_cellular_replicative0.78787910
86MP0003453_abnormal_keratinocyte_physiol0.78047248
87MP0003045_fibrosis0.77293259
88MP0005384_cellular_phenotype0.76261145
89MP0002089_abnormal_postnatal_growth/wei0.76059304
90MP0001119_abnormal_female_reproductive0.75819156
91MP0004947_skin_inflammation0.75060682
92MP0003123_paternal_imprinting0.73177289
93MP0002161_abnormal_fertility/fecundity0.71966025
94MP0005623_abnormal_meninges_morphology0.71585094
95MP0002086_abnormal_extraembryonic_tissu0.71572879
96MP0000003_abnormal_adipose_tissue0.69542334
97MP0005647_abnormal_sex_gland0.68429507
98MP0005075_abnormal_melanosome_morpholog0.68184273
99MP0010352_gastrointestinal_tract_polyps0.66345552
100MP0002080_prenatal_lethality0.65185496

Predicted human phenotypes

RankGene SetZ-score
1Gastrointestinal stroma tumor (HP:0100723)4.55211271
2Volvulus (HP:0002580)4.24827649
3Abnormality of the fingertips (HP:0001211)3.82222065
4Agammaglobulinemia (HP:0004432)3.72891318
5Recurrent sinusitis (HP:0011108)3.37205212
6Colitis (HP:0002583)3.27708425
7IgA deficiency (HP:0002720)2.99132846
8Increased nuchal translucency (HP:0010880)2.93967701
9Lymphopenia (HP:0001888)2.91608592
10Truncal obesity (HP:0001956)2.86861466
11Thoracic kyphosis (HP:0002942)2.85572847
12Basal cell carcinoma (HP:0002671)2.84475919
13Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.82008155
14Heterotopia (HP:0002282)2.80071644
15Macroorchidism (HP:0000053)2.77227571
16Abnormality of cells of the lymphoid lineage (HP:0012140)2.74615228
17Emphysema (HP:0002097)2.72890669
18Gastrointestinal inflammation (HP:0004386)2.67918332
19Recurrent viral infections (HP:0004429)2.66088660
20Abnormality of the thoracic spine (HP:0100711)2.64158004
21Obsessive-compulsive behavior (HP:0000722)2.63075098
22Meningitis (HP:0001287)2.60853638
23Inflammation of the large intestine (HP:0002037)2.56620056
24Vasculitis (HP:0002633)2.56166342
25Long eyelashes (HP:0000527)2.55823319
26Deep palmar crease (HP:0006191)2.55100629
27Horizontal nystagmus (HP:0000666)2.53895307
28Abnormal delayed hypersensitivity skin test (HP:0002963)2.50798063
29Recurrent cutaneous fungal infections (HP:0011370)2.50650584
30Chronic mucocutaneous candidiasis (HP:0002728)2.50650584
31Menstrual irregularities (HP:0000858)2.47863099
32Recurrent bronchitis (HP:0002837)2.47201139
33Vertebral arch anomaly (HP:0008438)2.44210467
34Chromosomal breakage induced by crosslinking agents (HP:0003221)2.36922481
3511 pairs of ribs (HP:0000878)2.35408961
36Abnormality of the lumbar spine (HP:0100712)2.32783656
37Panhypogammaglobulinemia (HP:0003139)2.32329694
38Chromsome breakage (HP:0040012)2.32168632
39Cellulitis (HP:0100658)2.31092006
40Abnormality of chromosome segregation (HP:0002916)2.28896162
41Low anterior hairline (HP:0000294)2.26505817
42Dysmetric saccades (HP:0000641)2.26224222
43Facial hemangioma (HP:0000329)2.23814759
44Viral hepatitis (HP:0006562)2.21935289
45Ectopic kidney (HP:0000086)2.21803694
46Metaphyseal cupping (HP:0003021)2.21748795
47Upper motor neuron abnormality (HP:0002127)2.21406105
48Amyotrophic lateral sclerosis (HP:0007354)2.21229603
49Deep philtrum (HP:0002002)2.17993147
50Fatigue (HP:0012378)2.17533910
51Chronic diarrhea (HP:0002028)2.14986944
52Squamous cell carcinoma (HP:0002860)2.13886009
53Mediastinal lymphadenopathy (HP:0100721)2.11373226
54Nephroblastoma (Wilms tumor) (HP:0002667)2.11120231
55Restrictive lung disease (HP:0002091)2.10397428
56Neonatal hypoglycemia (HP:0001998)2.07815569
57Prominent nose (HP:0000448)2.07172084
58Diastasis recti (HP:0001540)2.04281054
59Thick eyebrow (HP:0000574)2.00966041
60Recurrent bacterial skin infections (HP:0005406)2.00057896
61Low posterior hairline (HP:0002162)1.99673628
62Cafe-au-lait spot (HP:0000957)1.99220606
63Gonadotropin excess (HP:0000837)1.98644606
64Capillary hemangiomas (HP:0005306)1.98642423
65Aplasia/Hypoplasia of the sternum (HP:0006714)1.98408497
66Recurrent lower respiratory tract infections (HP:0002783)1.97767722
67Hepatitis (HP:0012115)1.96907060
68Embryonal renal neoplasm (HP:0011794)1.94324876
69Recurrent pneumonia (HP:0006532)1.93699618
70Asymmetry of the thorax (HP:0001555)1.91854462
71Poikiloderma (HP:0001029)1.90794435
72Overlapping toe (HP:0001845)1.89504495
73Recurrent fungal infections (HP:0002841)1.88557664
74Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.88546680
75Cutis marmorata (HP:0000965)1.88406540
76Abnormality of DNA repair (HP:0003254)1.88306522
77Papilloma (HP:0012740)1.86298417
78Verrucae (HP:0200043)1.86298417
79Papillary thyroid carcinoma (HP:0002895)1.85610339
80Synophrys (HP:0000664)1.84033418
81Abnormality of T cell physiology (HP:0011840)1.83062096
82Recurrent skin infections (HP:0001581)1.81612769
83Hyperacusis (HP:0010780)1.81268287
84Abnormal pancreas size (HP:0012094)1.80660646
85Hypoplastic iliac wings (HP:0002866)1.78524544
86Uterine leiomyosarcoma (HP:0002891)1.78260629
87Leiomyosarcoma (HP:0100243)1.78260629
88Leukopenia (HP:0001882)1.78054564
89Shoulder girdle muscle weakness (HP:0003547)1.77898103
90Tapered finger (HP:0001182)1.76693845
91Osteomyelitis (HP:0002754)1.74814728
92Transitional cell carcinoma of the bladder (HP:0006740)1.73511570
93Narrow palate (HP:0000189)1.72937441
94Proximal placement of thumb (HP:0009623)1.72360611
95Oligodactyly (hands) (HP:0001180)1.71775452
96IgM deficiency (HP:0002850)1.70991948
97Protruding tongue (HP:0010808)1.70341892
98Sandal gap (HP:0001852)1.68933626
99Abnormality of chromosome stability (HP:0003220)1.65986858
100Slow saccadic eye movements (HP:0000514)1.65400163

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK5.51818724
2CDK123.93335563
3CAMK1G3.67840773
4MAP3K103.14847365
5RIPK43.08840892
6PRPF4B2.97674396
7MAP3K92.48773684
8CSF1R2.46882158
9SIK22.45498185
10MAP4K12.45409836
11MAP3K132.32538083
12FGR2.17339753
13NEK92.05786287
14MET1.73840185
15MAP3K141.73134738
16BRD41.69589740
17TRIB31.62880161
18FGFR41.54415021
19FGFR31.54123742
20CDK191.52159775
21EEF2K1.51645563
22CAMK1D1.48365755
23PTK2B1.45596183
24PASK1.45413279
25IRAK41.36338199
26SMG11.34882483
27CDK41.27889178
28WNK11.27000987
29RET1.23097831
30BMX1.21953889
31BLK1.21701395
32YES11.16953657
33ICK1.15553281
34CDC42BPA1.12971684
35PDGFRB1.03378374
36SYK0.99469117
37ERN10.95859779
38SIK30.94286746
39TYK20.91196882
40MARK30.89705898
41KSR20.87486122
42LATS10.87250011
43TYRO30.85839027
44SGK20.84743828
45CHEK10.78404179
46MAPK110.78012683
47JAK10.77378780
48BTK0.77145252
49MTOR0.75742725
50MELK0.75354126
51CDK60.74929368
52BMPR20.72300492
53PDK10.69542617
54SIK10.68619139
55PKN20.66964990
56CAMKK10.66894483
57SGK30.65086518
58STK240.64644733
59PRKCH0.62633582
60IKBKE0.62483012
61CDK30.62053150
62PLK40.61131488
63MAP3K20.59570116
64EIF2AK30.56157989
65ATR0.54770872
66SGK10.51203499
67TAF10.51005742
68BRAF0.50714771
69PIM10.49021373
70CHUK0.48430602
71MARK20.48408251
72PDPK10.47270951
73NEK20.47170557
74ATM0.46545110
75MAPK70.46456047
76STK110.45948780
77PRKCI0.43659324
78JAK30.42539572
79ARAF0.41745041
80CDK20.41496448
81RAF10.41184249
82PDGFRA0.41137934
83PRKCQ0.40968644
84CDK90.40305749
85JAK20.39509783
86LYN0.39471196
87HCK0.39215844
88MAPK100.38617794
89MAP3K70.37903033
90RPS6KB10.37354077
91CDK70.37337015
92MAP2K20.36765638
93CSK0.36089354
94KIT0.35794778
95STK100.35451111
96ITK0.35416490
97MAPK10.33661036
98NLK0.32244429
99RPS6KC10.32095078
100RPS6KL10.32095078

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046623.12898120
2Intestinal immune network for IgA production_Homo sapiens_hsa046722.60363093
3Allograft rejection_Homo sapiens_hsa053302.42098387
4Primary immunodeficiency_Homo sapiens_hsa053402.40972261
5Autoimmune thyroid disease_Homo sapiens_hsa053202.18945320
6Graft-versus-host disease_Homo sapiens_hsa053322.07695182
7Asthma_Homo sapiens_hsa053101.95539041
8Type I diabetes mellitus_Homo sapiens_hsa049401.85947911
9Viral myocarditis_Homo sapiens_hsa054161.85776401
10Leishmaniasis_Homo sapiens_hsa051401.79102513
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.73991063
12Influenza A_Homo sapiens_hsa051641.67734208
13Non-small cell lung cancer_Homo sapiens_hsa052231.64157264
14Herpes simplex infection_Homo sapiens_hsa051681.63715328
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.59652304
16Acute myeloid leukemia_Homo sapiens_hsa052211.58604665
17Chronic myeloid leukemia_Homo sapiens_hsa052201.56295441
18T cell receptor signaling pathway_Homo sapiens_hsa046601.55137446
19ErbB signaling pathway_Homo sapiens_hsa040121.47937860
20Measles_Homo sapiens_hsa051621.47555188
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.44368508
22Antigen processing and presentation_Homo sapiens_hsa046121.44100781
23mRNA surveillance pathway_Homo sapiens_hsa030151.41561110
24Dorso-ventral axis formation_Homo sapiens_hsa043201.40449599
25Prostate cancer_Homo sapiens_hsa052151.36905387
26Hepatitis B_Homo sapiens_hsa051611.36824545
27Toxoplasmosis_Homo sapiens_hsa051451.36794825
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.34018790
29Lysine degradation_Homo sapiens_hsa003101.33912151
30Endometrial cancer_Homo sapiens_hsa052131.30583738
31mTOR signaling pathway_Homo sapiens_hsa041501.27949858
32Cell cycle_Homo sapiens_hsa041101.25724929
33Renal cell carcinoma_Homo sapiens_hsa052111.25699177
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.24942806
35Epstein-Barr virus infection_Homo sapiens_hsa051691.23355645
36Neurotrophin signaling pathway_Homo sapiens_hsa047221.22583001
37Pancreatic cancer_Homo sapiens_hsa052121.21798285
38Choline metabolism in cancer_Homo sapiens_hsa052311.20922735
39Staphylococcus aureus infection_Homo sapiens_hsa051501.16993438
40VEGF signaling pathway_Homo sapiens_hsa043701.16597085
41Toll-like receptor signaling pathway_Homo sapiens_hsa046201.15453977
42Colorectal cancer_Homo sapiens_hsa052101.14881616
43Osteoclast differentiation_Homo sapiens_hsa043801.14598853
44HTLV-I infection_Homo sapiens_hsa051661.14174396
45Small cell lung cancer_Homo sapiens_hsa052221.10751991
46Prolactin signaling pathway_Homo sapiens_hsa049171.10117926
47Thyroid hormone signaling pathway_Homo sapiens_hsa049191.08990482
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08422502
49Viral carcinogenesis_Homo sapiens_hsa052031.04007204
50Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.02320036
51Tuberculosis_Homo sapiens_hsa051521.01120359
52Inositol phosphate metabolism_Homo sapiens_hsa005620.99826553
53Jak-STAT signaling pathway_Homo sapiens_hsa046300.93156923
54Apoptosis_Homo sapiens_hsa042100.90969163
55MicroRNAs in cancer_Homo sapiens_hsa052060.88761978
56Chemokine signaling pathway_Homo sapiens_hsa040620.85143213
57TNF signaling pathway_Homo sapiens_hsa046680.83741114
58Hepatitis C_Homo sapiens_hsa051600.83639781
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83540327
60RNA transport_Homo sapiens_hsa030130.83500132
61Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82582231
62Glioma_Homo sapiens_hsa052140.81939212
63Type II diabetes mellitus_Homo sapiens_hsa049300.80945714
64Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.80851162
65Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79701568
66FoxO signaling pathway_Homo sapiens_hsa040680.78137060
67Estrogen signaling pathway_Homo sapiens_hsa049150.76453273
68MAPK signaling pathway_Homo sapiens_hsa040100.75618289
69Fanconi anemia pathway_Homo sapiens_hsa034600.74956962
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.74874491
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71627829
72GnRH signaling pathway_Homo sapiens_hsa049120.69220977
73Non-homologous end-joining_Homo sapiens_hsa034500.68765905
74Insulin signaling pathway_Homo sapiens_hsa049100.68211689
75Oocyte meiosis_Homo sapiens_hsa041140.68038145
76Notch signaling pathway_Homo sapiens_hsa043300.64868765
77Long-term potentiation_Homo sapiens_hsa047200.62663906
78Fatty acid biosynthesis_Homo sapiens_hsa000610.62213651
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61664900
80RNA degradation_Homo sapiens_hsa030180.60875358
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.57704788
82Thyroid cancer_Homo sapiens_hsa052160.57197104
83Insulin resistance_Homo sapiens_hsa049310.56146224
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.55895078
85Hematopoietic cell lineage_Homo sapiens_hsa046400.54528720
86Adherens junction_Homo sapiens_hsa045200.53637933
87HIF-1 signaling pathway_Homo sapiens_hsa040660.53634062
88N-Glycan biosynthesis_Homo sapiens_hsa005100.52985531
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52649625
90Proteoglycans in cancer_Homo sapiens_hsa052050.48938330
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.48016872
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46696261
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44779971
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.42063279
95Homologous recombination_Homo sapiens_hsa034400.41364308
96Platelet activation_Homo sapiens_hsa046110.41105714
97DNA replication_Homo sapiens_hsa030300.40696699
98p53 signaling pathway_Homo sapiens_hsa041150.38617977
99Shigellosis_Homo sapiens_hsa051310.36170635
100Focal adhesion_Homo sapiens_hsa045100.35242092

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