ZNF319

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)5.92244938
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.92244938
3positive regulation by symbiont of host defense response (GO:0052509)5.03857128
4modulation by symbiont of host defense response (GO:0052031)5.03857128
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.03857128
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.03857128
7positive regulation by organism of defense response of other organism involved in symbiotic interact5.03857128
8modulation by symbiont of host immune response (GO:0052553)5.03857128
9positive regulation of gamma-delta T cell activation (GO:0046645)4.86309611
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.78993045
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.66705622
12response to peptidoglycan (GO:0032494)4.61816475
13macrophage activation involved in immune response (GO:0002281)4.54774675
14antigen processing and presentation of endogenous antigen (GO:0019883)4.44743731
15leukocyte aggregation (GO:0070486)4.38602667
16neutrophil activation involved in immune response (GO:0002283)4.25058993
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.24960682
18detection of other organism (GO:0098543)4.17634951
19detection of bacterium (GO:0016045)4.03708672
20regulation of interferon-beta biosynthetic process (GO:0045357)3.97685930
21negative regulation of erythrocyte differentiation (GO:0045647)3.95883784
22response to muramyl dipeptide (GO:0032495)3.84215774
23regulation of B cell receptor signaling pathway (GO:0050855)3.80824491
24negative regulation of interleukin-12 production (GO:0032695)3.80169595
25negative regulation of lymphocyte mediated immunity (GO:0002707)3.69075159
26positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.66158275
27detection of external biotic stimulus (GO:0098581)3.55415807
28regulation of gamma-delta T cell activation (GO:0046643)3.53099914
29cellular extravasation (GO:0045123)3.47126944
30detection of molecule of bacterial origin (GO:0032490)3.44235182
31negative regulation of leukocyte mediated immunity (GO:0002704)3.40267738
32germinal center formation (GO:0002467)3.38100626
33positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.36871087
34response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.33466374
35response to host immune response (GO:0052572)3.33466374
36response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.30689243
37response to host (GO:0075136)3.30689243
38response to host defenses (GO:0052200)3.30689243
39immunoglobulin mediated immune response (GO:0016064)3.27779260
40response to interleukin-15 (GO:0070672)3.26474914
41neutrophil activation (GO:0042119)3.24197665
42regulation of T-helper 2 cell differentiation (GO:0045628)3.21312460
43negative regulation of T cell mediated immunity (GO:0002710)3.20346690
44NIK/NF-kappaB signaling (GO:0038061)3.18904777
45detection of biotic stimulus (GO:0009595)3.14416407
46granulocyte activation (GO:0036230)3.09886733
47negative regulation of type 2 immune response (GO:0002829)3.09585941
48positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.06564532
49negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.06535684
50lipopolysaccharide-mediated signaling pathway (GO:0031663)3.03737811
51myeloid cell activation involved in immune response (GO:0002275)3.03737473
52positive thymic T cell selection (GO:0045059)3.02823079
53regulation of T cell tolerance induction (GO:0002664)3.00390834
54cellular response to interleukin-15 (GO:0071350)2.99966304
55tolerance induction (GO:0002507)2.99151382
56regulation of mast cell degranulation (GO:0043304)2.98224974
57B cell receptor signaling pathway (GO:0050853)2.98124782
58respiratory burst (GO:0045730)2.97017717
59regulation of gamma-delta T cell differentiation (GO:0045586)2.96939488
60regulation of leukocyte degranulation (GO:0043300)2.95689440
61type I interferon signaling pathway (GO:0060337)2.95546148
62cellular response to type I interferon (GO:0071357)2.95546148
63leukocyte migration involved in inflammatory response (GO:0002523)2.95098533
64response to type I interferon (GO:0034340)2.93251577
65regulation of myeloid leukocyte mediated immunity (GO:0002886)2.91737420
66macrophage activation (GO:0042116)2.91391766
67regulation of tolerance induction (GO:0002643)2.87778430
68T cell homeostasis (GO:0043029)2.87289234
69negative regulation of interleukin-6 production (GO:0032715)2.86994943
70negative regulation of cytokine production involved in immune response (GO:0002719)2.86364318
71negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.85501876
72response to laminar fluid shear stress (GO:0034616)2.84017017
73negative regulation of innate immune response (GO:0045824)2.82117507
74antigen processing and presentation via MHC class Ib (GO:0002475)2.80002032
75negative thymic T cell selection (GO:0045060)2.79755733
76signal complex assembly (GO:0007172)2.77163746
77regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.77091894
78positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.76846066
79thymic T cell selection (GO:0045061)2.75326518
80positive regulation of B cell differentiation (GO:0045579)2.74971901
81T cell migration (GO:0072678)2.74256788
82negative regulation of toll-like receptor signaling pathway (GO:0034122)2.73764800
83regulation of type 2 immune response (GO:0002828)2.72976730
84positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.71921441
85negative T cell selection (GO:0043383)2.69568745
86regulation of natural killer cell mediated immunity (GO:0002715)2.69561184
87regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.69561184
88negative regulation of T-helper cell differentiation (GO:0045623)2.67497237
89negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.67497237
90regulation of B cell differentiation (GO:0045577)2.66529854
91T cell selection (GO:0045058)2.66060362
92regulation of mast cell activation involved in immune response (GO:0033006)2.62800874
93protein localization to endosome (GO:0036010)2.62372749
94microglial cell activation (GO:0001774)2.61911192
95defense response to protozoan (GO:0042832)2.60074565
96neutrophil mediated immunity (GO:0002446)2.59849572
97B cell homeostasis (GO:0001782)2.59760203
98positive regulation of cellular amide metabolic process (GO:0034250)2.57263807
99regulation of platelet aggregation (GO:0090330)2.56868895
100positive regulation of tolerance induction (GO:0002645)2.56496543

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human3.26257115
2IRF8_22096565_ChIP-ChIP_GC-B_Human2.91791093
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.87666001
4KDM2B_26808549_Chip-Seq_SUP-B15_Human2.85676942
5MYC_22102868_ChIP-Seq_BL_Human2.82432718
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.76683254
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.61285978
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.60410296
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.52738856
10VDR_24763502_ChIP-Seq_THP-1_Human2.51686536
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.48882777
12KDM2B_26808549_Chip-Seq_DND41_Human2.45998926
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.45234203
14KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.44858675
15TCF7_22412390_ChIP-Seq_EML_Mouse2.44232534
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.40711302
17IRF8_21731497_ChIP-ChIP_J774_Mouse2.38466300
18MAF_26560356_Chip-Seq_TH1_Human2.38128375
19STAT6_21828071_ChIP-Seq_BEAS2B_Human2.36462185
20ELK3_25401928_ChIP-Seq_HUVEC_Human2.36160739
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.32011374
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.27997068
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.27818058
24LXR_22292898_ChIP-Seq_THP-1_Human2.25733646
25UTX_26944678_Chip-Seq_JUKART_Human2.10539689
26KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.08915711
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.06229273
28MYB_21317192_ChIP-Seq_ERMYB_Mouse2.01613420
29IRF8_27001747_Chip-Seq_BMDM_Mouse1.99531240
30SPI1_23127762_ChIP-Seq_K562_Human1.96327484
31RUNX1_22412390_ChIP-Seq_EML_Mouse1.94910774
32RUNX_20019798_ChIP-Seq_JUKART_Human1.94849886
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.90660663
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88951505
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.85386218
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.84935134
37MAF_26560356_Chip-Seq_TH2_Human1.84860274
38TP63_17297297_ChIP-ChIP_HaCaT_Human1.83313695
39KDM2B_26808549_Chip-Seq_JURKAT_Human1.78713312
40FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.78126645
41STAT4_19710469_ChIP-ChIP_TH1__Mouse1.76091541
42SPI1_23547873_ChIP-Seq_NB4_Human1.73238369
43* KDM2B_26808549_Chip-Seq_K562_Human1.72174033
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.71608097
45RACK7_27058665_Chip-Seq_MCF-7_Human1.66883305
46STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.63400960
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.61496709
48TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.52482460
49MYB_26560356_Chip-Seq_TH2_Human1.50570542
50SCL_19346495_ChIP-Seq_HPC-7_Human1.47354875
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.46283851
52MYB_26560356_Chip-Seq_TH1_Human1.43898413
53GATA1_19941827_ChIP-Seq_MEL_Mouse1.43515381
54IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.41992377
55CTCF_27219007_Chip-Seq_ERYTHROID_Human1.37799545
56PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33793751
57IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.32690440
58EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31975417
59SA1_27219007_Chip-Seq_ERYTHROID_Human1.31745519
60CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31704191
61TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28957236
62KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26756469
63Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.25610614
64GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24179984
65PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21513926
66CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20790518
67VDR_24787735_ChIP-Seq_THP-1_Human1.20616466
68KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19863338
69ESR2_21235772_ChIP-Seq_MCF-7_Human1.18170547
70P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17978289
71ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17184134
72SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16478158
73* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14587586
74PU.1_20513432_ChIP-Seq_Bcells_Mouse1.14461058
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14024705
76UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12559798
77LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.11037599
78GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10465211
79* NCOR1_26117541_ChIP-Seq_K562_Human1.08889123
80GATA2_22383799_ChIP-Seq_G1ME_Mouse1.07892705
81STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07525088
82RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06255629
83P68_20966046_ChIP-Seq_HELA_Human1.04894008
84CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04557939
85SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04542774
86GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04212667
87GATA1_19941826_ChIP-Seq_K562_Human1.03581394
88SMC4_20622854_ChIP-Seq_HELA_Human1.02864211
89GATA3_27048872_Chip-Seq_THYMUS_Human1.02863588
90DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02052227
91BCL6_27268052_Chip-Seq_Bcells_Human1.01853445
92BCOR_27268052_Chip-Seq_Bcells_Human0.99162604
93PU_27001747_Chip-Seq_BMDM_Mouse0.97569799
94CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96454040
95FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.96408869
96ELF1_20517297_ChIP-Seq_JURKAT_Human0.95017667
97CREB1_26743006_Chip-Seq_LNCaP_Human0.92112704
98ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.91528593
99TET1_21451524_ChIP-Seq_MESCs_Mouse0.90540217
100ZFP281_27345836_Chip-Seq_ESCs_Mouse0.90021815

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.15498565
2MP0003303_peritoneal_inflammation3.78742369
3MP0003724_increased_susceptibility_to3.59565862
4MP0001835_abnormal_antigen_presentation2.98495003
5MP0005451_abnormal_body_composition2.81141704
6MP0000685_abnormal_immune_system2.79874654
7MP0002419_abnormal_innate_immunity2.79486549
8MP0005025_abnormal_response_to2.63811088
9MP0003300_gastrointestinal_ulcer2.63626123
10MP0005000_abnormal_immune_tolerance2.62264056
11MP0005387_immune_system_phenotype2.62068858
12MP0001790_abnormal_immune_system2.62068858
13MP0001800_abnormal_humoral_immune2.55104082
14MP0005671_abnormal_response_to2.53457503
15MP0009785_altered_susceptibility_to2.40930197
16MP0003191_abnormal_cellular_cholesterol2.40478480
17MP0003705_abnormal_hypodermis_morpholog2.33865391
18MP0002723_abnormal_immune_serum2.33757487
19MP0003763_abnormal_thymus_physiology2.30764246
20MP0002420_abnormal_adaptive_immunity2.28969483
21MP0001819_abnormal_immune_cell2.25636427
22MP0002452_abnormal_antigen_presenting2.25320615
23MP0004947_skin_inflammation2.24287846
24MP0006082_CNS_inflammation2.22817185
25MP0009333_abnormal_splenocyte_physiolog2.10376866
26MP0002148_abnormal_hypersensitivity_rea2.01991854
27MP0005464_abnormal_platelet_physiology1.99325152
28MP0002405_respiratory_system_inflammati1.98158584
29MP0003828_pulmonary_edema1.95348464
30MP0001533_abnormal_skeleton_physiology1.93113702
31MP0003172_abnormal_lysosome_physiology1.85597973
32MP0009278_abnormal_bone_marrow1.79141300
33MP0002398_abnormal_bone_marrow1.77975774
34MP0000716_abnormal_immune_system1.75409675
35MP0004510_myositis1.72095293
36MP0010155_abnormal_intestine_physiology1.61711669
37MP0002998_abnormal_bone_remodeling1.57875882
38MP0000858_altered_metastatic_potential1.56754106
39MP0008260_abnormal_autophagy1.53985707
40MP0005058_abnormal_lysosome_morphology1.53957164
41MP0000703_abnormal_thymus_morphology1.51309376
42MP0001845_abnormal_inflammatory_respons1.47380832
43MP0003091_abnormal_cell_migration1.45915590
44MP0002722_abnormal_immune_system1.42489243
45MP0002429_abnormal_blood_cell1.37558930
46MP0003075_altered_response_to1.36984166
47MP0002132_abnormal_respiratory_system1.34340023
48MP0000689_abnormal_spleen_morphology1.34222081
49MP0003453_abnormal_keratinocyte_physiol1.34042787
50MP0001851_eye_inflammation1.28264502
51MP0008004_abnormal_stomach_pH1.26717296
52MP0004381_abnormal_hair_follicle1.26130740
53MP0008469_abnormal_protein_level1.25767505
54MP0003183_abnormal_peptide_metabolism1.24900885
55MP0005076_abnormal_cell_differentiation1.22701298
56MP0001873_stomach_inflammation1.19257165
57MP0003566_abnormal_cell_adhesion1.19246156
58MP0009840_abnormal_foam_cell1.17588240
59MP0003279_aneurysm1.14174487
60MP0000465_gastrointestinal_hemorrhage1.13128285
61MP0003448_altered_tumor_morphology1.13103546
62MP0004883_abnormal_blood_vessel1.13030743
63MP0005310_abnormal_salivary_gland1.13014577
64MP0001849_ear_inflammation1.12092091
65MP0003866_abnormal_defecation1.12055919
66MP0009764_decreased_sensitivity_to1.08636792
67MP0001853_heart_inflammation1.08523814
68MP0002396_abnormal_hematopoietic_system1.06778425
69MP0005166_decreased_susceptibility_to1.04199640
70MP0005397_hematopoietic_system_phenotyp1.03114469
71MP0001545_abnormal_hematopoietic_system1.03114469
72MP0004808_abnormal_hematopoietic_stem0.98669272
73MP0005390_skeleton_phenotype0.96356833
74MP0001348_abnormal_lacrimal_gland0.96090859
75MP0002933_joint_inflammation0.95774000
76MP0004130_abnormal_muscle_cell0.93969090
77MP0000604_amyloidosis0.93466893
78MP0004858_abnormal_nervous_system0.92896147
79MP0003690_abnormal_glial_cell0.92885178
80MP0005164_abnormal_response_to0.91219381
81MP0000343_altered_response_to0.91193967
82MP0005023_abnormal_wound_healing0.84808706
83MP0001958_emphysema0.83429117
84MP0000490_abnormal_crypts_of0.80729667
85MP0004185_abnormal_adipocyte_glucose0.80729237
86MP0000767_abnormal_smooth_muscle0.78648543
87MP0002166_altered_tumor_susceptibility0.77785139
88MP0001663_abnormal_digestive_system0.77722660
89MP0008874_decreased_physiological_sensi0.77533529
90MP0002277_abnormal_respiratory_mucosa0.74864659
91MP0003795_abnormal_bone_structure0.71544246
92MP0000733_abnormal_muscle_development0.71075812
93MP0001915_intracranial_hemorrhage0.69126704
94MP0000678_abnormal_parathyroid_gland0.67360941
95MP0003329_amyloid_beta_deposits0.67130406
96MP0000249_abnormal_blood_vessel0.65641472
97MP0002332_abnormal_exercise_endurance0.64260413
98MP0003221_abnormal_cardiomyocyte_apopto0.62110603
99MP0009763_increased_sensitivity_to0.59941832
100MP0010234_abnormal_vibrissa_follicle0.55994344

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.49450040
2Recurrent bacterial skin infections (HP:0005406)4.93307878
3Recurrent abscess formation (HP:0002722)4.82171149
4Abnormality of macrophages (HP:0004311)4.63609616
5Myositis (HP:0100614)4.12743214
6Orchitis (HP:0100796)3.94851591
7Increased IgE level (HP:0003212)3.78671481
8Retrobulbar optic neuritis (HP:0100654)3.49821380
9Optic neuritis (HP:0100653)3.49821380
10Mediastinal lymphadenopathy (HP:0100721)3.35833102
11Recurrent gram-negative bacterial infections (HP:0005420)3.27453377
12Elevated erythrocyte sedimentation rate (HP:0003565)3.26199129
13Meningitis (HP:0001287)3.19914581
14Spontaneous hematomas (HP:0007420)3.19573689
15Recurrent skin infections (HP:0001581)3.16372428
16Cellulitis (HP:0100658)3.14208034
17Recurrent fungal infections (HP:0002841)3.14151323
18Pustule (HP:0200039)3.01858418
19Obstructive lung disease (HP:0006536)2.99207260
20Chronic obstructive pulmonary disease (HP:0006510)2.99207260
21Gastrointestinal infarctions (HP:0005244)2.87906990
22Stomatitis (HP:0010280)2.86773226
23Gingivitis (HP:0000230)2.85681799
24Abnormal delayed hypersensitivity skin test (HP:0002963)2.84179155
25Recurrent cutaneous fungal infections (HP:0011370)2.73982972
26Chronic mucocutaneous candidiasis (HP:0002728)2.73982972
27Urticaria (HP:0001025)2.73648306
28Vasculitis (HP:0002633)2.63462192
29Keratoconjunctivitis sicca (HP:0001097)2.56380431
30Recurrent viral infections (HP:0004429)2.51652391
31Encephalitis (HP:0002383)2.47985884
32Peritonitis (HP:0002586)2.46282523
33Gastrointestinal inflammation (HP:0004386)2.34788456
34Abnormality of liposaccharide metabolism (HP:0010968)2.33582882
35Abnormality of glycosphingolipid metabolism (HP:0004343)2.33582882
36Abnormality of glycolipid metabolism (HP:0010969)2.33582882
37Hypochromic anemia (HP:0001931)2.32936163
38Keratoconjunctivitis (HP:0001096)2.32648893
39Chest pain (HP:0100749)2.31680238
40Inflammation of the large intestine (HP:0002037)2.30465476
41Prolonged bleeding time (HP:0003010)2.27734958
42T lymphocytopenia (HP:0005403)2.26937483
43Panhypogammaglobulinemia (HP:0003139)2.18710520
44Axonal loss (HP:0003447)2.15900477
45Colitis (HP:0002583)2.13488997
46Loss of speech (HP:0002371)2.12320797
47Slow saccadic eye movements (HP:0000514)2.10790511
48Obstructive sleep apnea (HP:0002870)2.09880626
49Abnormality of T cell number (HP:0011839)2.09616641
50Pulmonary infiltrates (HP:0002113)2.09156454
51Hypochromic microcytic anemia (HP:0004840)2.07901438
52Leukocytosis (HP:0001974)2.07532170
53Hemoptysis (HP:0002105)2.07203504
54Hypergammaglobulinemia (HP:0010702)2.04483888
55Nasal polyposis (HP:0100582)2.04388973
56Epistaxis (HP:0000421)2.03103685
57Sepsis (HP:0100806)2.02282634
58Osteomyelitis (HP:0002754)2.01843714
59Gingival bleeding (HP:0000225)1.99889812
60Difficulty running (HP:0009046)1.98559381
61Emphysema (HP:0002097)1.96897796
62Hyperacusis (HP:0010780)1.95734698
63Episodic fever (HP:0001954)1.95319190
64Arterial thrombosis (HP:0004420)1.94888516
65Pulmonary embolism (HP:0002204)1.92823945
66Increased cerebral lipofuscin (HP:0011813)1.92749318
67Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.92425716
68Abnormality of the nasal mucosa (HP:0000433)1.91436799
69Gastrointestinal stroma tumor (HP:0100723)1.90352574
70Abnormality of the peritoneum (HP:0002585)1.89299887
71Increased IgM level (HP:0003496)1.88564903
72Spondylolisthesis (HP:0003302)1.88296466
73Granulocytopenia (HP:0001913)1.87068606
74Increased serum ferritin (HP:0003281)1.86312236
75Interstitial pulmonary disease (HP:0006530)1.85204056
76Amyloidosis (HP:0011034)1.85057074
77Dysostosis multiplex (HP:0000943)1.84769578
78Supranuclear gaze palsy (HP:0000605)1.84120447
79Petechiae (HP:0000967)1.83997360
80Increased connective tissue (HP:0009025)1.83701773
81Centrally nucleated skeletal muscle fibers (HP:0003687)1.83698742
82Agammaglobulinemia (HP:0004432)1.83528828
83Premature loss of primary teeth (HP:0006323)1.82489317
84Purpura (HP:0000979)1.82200575
85Distal lower limb muscle weakness (HP:0009053)1.81551617
86Lymphopenia (HP:0001888)1.81146276
87Dilatation of the ascending aorta (HP:0005111)1.79008647
88Papilloma (HP:0012740)1.76816928
89Verrucae (HP:0200043)1.76816928
90Segmental peripheral demyelination/remyelination (HP:0003481)1.76491481
91Muscle fiber splitting (HP:0003555)1.75180889
92Microcytic anemia (HP:0001935)1.74992111
93Cerebral aneurysm (HP:0004944)1.74917815
94Thin bony cortex (HP:0002753)1.73735216
95Abnormality of the endocardium (HP:0004306)1.73603717
96Abnormality of the fingertips (HP:0001211)1.73535525
97Broad face (HP:0000283)1.72543617
98Abnormality of cells of the lymphoid lineage (HP:0012140)1.72173136
99Abnormality of skeletal muscle fiber size (HP:0012084)1.70836210
100Viral hepatitis (HP:0006562)1.70792270

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.42580753
2RIPK43.17248956
3ERN13.01796865
4MAP4K12.86821574
5TRIB32.59726757
6MAP2K32.59547560
7IRAK42.28262931
8CSK2.16335222
9FES2.06936009
10EPHB12.01543577
11TYK21.97470958
12TNK21.93717683
13SIK11.87695435
14MAP3K111.85833323
15BLK1.85155377
16TAOK11.84444116
17MAP3K31.80954780
18SIK21.80599418
19SMG11.76951754
20ZAP701.72801761
21SIK31.72277857
22ICK1.71618946
23MAP3K141.55332812
24MARK21.48970239
25PRKD21.47514309
26IRAK21.45386706
27TAOK21.42021853
28GRK61.40482160
29IKBKE1.40359550
30TBK11.40214753
31MAP3K131.38323994
32MAP3K11.36658113
33IRAK31.36186390
34BTK1.35571677
35KSR21.33817584
36HCK1.26815958
37FGR1.25258517
38JAK31.20405686
39TTN1.14476869
40CDC42BPA1.10355549
41SYK1.08548245
42RIPK11.06482529
43HIPK21.04802758
44DYRK1B1.03900566
45MAP3K101.03838988
46TXK1.03253884
47JAK11.02041048
48MAP3K60.96433060
49CDK120.91732831
50JAK20.88577505
51LRRK20.84366581
52MAPK120.84202785
53LCK0.83830093
54PTK60.83563131
55LYN0.82783939
56STK100.82389944
57CSF1R0.81750523
58FGFR40.80241912
59TGFBR20.79490152
60TYRO30.77425704
61MAP3K70.77096419
62DYRK30.77082413
63PDPK10.74082346
64SGK30.72003301
65MAP3K20.69957458
66MATK0.69819077
67IKBKB0.68242264
68RPS6KA20.67717776
69ITK0.67280921
70PDK10.66820131
71MAPK70.66394896
72TESK20.65541710
73RPS6KC10.63183051
74RPS6KL10.63183051
75IRAK10.60168806
76MARK30.59755904
77CDK190.57181502
78FYN0.55538266
79YES10.54223329
80PKN20.52822854
81MOS0.52140929
82NME20.51137238
83CAMKK10.49842792
84MELK0.48815996
85EEF2K0.48621369
86PRKCH0.46656456
87KIT0.45262073
88RPS6KA60.44612474
89RET0.44490178
90MAPKAPK20.43998498
91STK380.43003023
92STK110.42327541
93PDGFRB0.40892535
94FGFR30.39125300
95MAP3K80.38789267
96PAK40.38614724
97MTOR0.38488399
98CHUK0.38017248
99MAPK40.36753806
100CAMK40.36537724

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043802.63487894
2Leishmaniasis_Homo sapiens_hsa051402.25315941
3B cell receptor signaling pathway_Homo sapiens_hsa046622.18793478
4Toll-like receptor signaling pathway_Homo sapiens_hsa046201.95152087
5Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.94736865
6Acute myeloid leukemia_Homo sapiens_hsa052211.91991175
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.90735595
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.84536362
9Tuberculosis_Homo sapiens_hsa051521.72821955
10Malaria_Homo sapiens_hsa051441.70767317
11T cell receptor signaling pathway_Homo sapiens_hsa046601.65840653
12Staphylococcus aureus infection_Homo sapiens_hsa051501.65781582
13Notch signaling pathway_Homo sapiens_hsa043301.65763629
14Primary immunodeficiency_Homo sapiens_hsa053401.65264048
15Chronic myeloid leukemia_Homo sapiens_hsa052201.58527939
16Other glycan degradation_Homo sapiens_hsa005111.57485534
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.56800716
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.54970722
19Measles_Homo sapiens_hsa051621.53906553
20Non-small cell lung cancer_Homo sapiens_hsa052231.49628950
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.48686773
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.48362809
23Graft-versus-host disease_Homo sapiens_hsa053321.46894819
24TNF signaling pathway_Homo sapiens_hsa046681.44981448
25Chemokine signaling pathway_Homo sapiens_hsa040621.43928181
26Allograft rejection_Homo sapiens_hsa053301.42259609
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.39689473
28Pancreatic cancer_Homo sapiens_hsa052121.38017327
29Toxoplasmosis_Homo sapiens_hsa051451.37816273
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.35157006
31Hepatitis B_Homo sapiens_hsa051611.33818380
32Autoimmune thyroid disease_Homo sapiens_hsa053201.33660098
33Influenza A_Homo sapiens_hsa051641.33124554
34VEGF signaling pathway_Homo sapiens_hsa043701.30191855
35Neurotrophin signaling pathway_Homo sapiens_hsa047221.27703830
36Viral myocarditis_Homo sapiens_hsa054161.27210818
37Renal cell carcinoma_Homo sapiens_hsa052111.25011867
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.23884078
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.23338321
40Leukocyte transendothelial migration_Homo sapiens_hsa046701.16880803
41Hematopoietic cell lineage_Homo sapiens_hsa046401.16289686
42Hepatitis C_Homo sapiens_hsa051601.15124125
43Endometrial cancer_Homo sapiens_hsa052131.11632961
44Herpes simplex infection_Homo sapiens_hsa051681.09333107
45Shigellosis_Homo sapiens_hsa051311.09137910
46Legionellosis_Homo sapiens_hsa051341.08029345
47Salmonella infection_Homo sapiens_hsa051321.06860652
48Amoebiasis_Homo sapiens_hsa051461.05138291
49Jak-STAT signaling pathway_Homo sapiens_hsa046301.05056219
50Phagosome_Homo sapiens_hsa041451.03247655
51African trypanosomiasis_Homo sapiens_hsa051431.02480703
52Apoptosis_Homo sapiens_hsa042101.01977980
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00442683
54Prolactin signaling pathway_Homo sapiens_hsa049170.99416056
55Pertussis_Homo sapiens_hsa051330.98213014
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97797394
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.95561571
58Antigen processing and presentation_Homo sapiens_hsa046120.94456493
59FoxO signaling pathway_Homo sapiens_hsa040680.91962611
60Endocytosis_Homo sapiens_hsa041440.90914479
61Colorectal cancer_Homo sapiens_hsa052100.86722551
62GnRH signaling pathway_Homo sapiens_hsa049120.86341651
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.86131925
64Glycosaminoglycan degradation_Homo sapiens_hsa005310.85585295
65mTOR signaling pathway_Homo sapiens_hsa041500.85428761
66Platelet activation_Homo sapiens_hsa046110.85158703
67Type I diabetes mellitus_Homo sapiens_hsa049400.85064100
68Lysosome_Homo sapiens_hsa041420.80982572
69Bladder cancer_Homo sapiens_hsa052190.80600226
70ErbB signaling pathway_Homo sapiens_hsa040120.79335472
71Rheumatoid arthritis_Homo sapiens_hsa053230.76629046
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.76418402
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73176181
74Choline metabolism in cancer_Homo sapiens_hsa052310.72790583
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72552432
76Glioma_Homo sapiens_hsa052140.71574514
77MAPK signaling pathway_Homo sapiens_hsa040100.71340903
78HTLV-I infection_Homo sapiens_hsa051660.71196295
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71088976
80Insulin resistance_Homo sapiens_hsa049310.70528622
81Long-term potentiation_Homo sapiens_hsa047200.68961091
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68946059
83Prion diseases_Homo sapiens_hsa050200.68826476
84Intestinal immune network for IgA production_Homo sapiens_hsa046720.67006728
85Viral carcinogenesis_Homo sapiens_hsa052030.65675832
86Prostate cancer_Homo sapiens_hsa052150.65447964
87Insulin signaling pathway_Homo sapiens_hsa049100.63961092
88Thyroid cancer_Homo sapiens_hsa052160.62186113
89Epstein-Barr virus infection_Homo sapiens_hsa051690.61586554
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61491524
91Estrogen signaling pathway_Homo sapiens_hsa049150.61198444
92Rap1 signaling pathway_Homo sapiens_hsa040150.59578691
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59555520
94Small cell lung cancer_Homo sapiens_hsa052220.59350624
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58463118
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57911511
97Inositol phosphate metabolism_Homo sapiens_hsa005620.57666551
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.56682935
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55627694
100HIF-1 signaling pathway_Homo sapiens_hsa040660.54746690

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »