ZNF320

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ZNF320 encodes a Kruppel-like zinc finger protein. Members of this protein family are involved in activation or repression of transcription. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.47493343
2sulfation (GO:0051923)3.94295707
3water-soluble vitamin biosynthetic process (GO:0042364)3.63867500
4regulation of posttranscriptional gene silencing (GO:0060147)3.54789590
5regulation of gene silencing by miRNA (GO:0060964)3.54789590
6regulation of gene silencing by RNA (GO:0060966)3.54789590
7kynurenine metabolic process (GO:0070189)3.51707274
8indole-containing compound catabolic process (GO:0042436)3.47256815
9indolalkylamine catabolic process (GO:0046218)3.47256815
10tryptophan catabolic process (GO:0006569)3.47256815
11kidney morphogenesis (GO:0060993)3.44335355
12L-fucose metabolic process (GO:0042354)3.38151704
13L-fucose catabolic process (GO:0042355)3.38151704
14fucose catabolic process (GO:0019317)3.38151704
15indolalkylamine metabolic process (GO:0006586)3.37145170
16negative regulation of telomere maintenance (GO:0032205)3.35934543
17DNA deamination (GO:0045006)3.30141818
18somite development (GO:0061053)3.29870146
19epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.22246718
20detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.11603594
21regulation of mesoderm development (GO:2000380)3.09861249
22protein polyglutamylation (GO:0018095)3.09591204
23response to pheromone (GO:0019236)3.05493995
24tryptophan metabolic process (GO:0006568)3.01492358
25regulation of hippo signaling (GO:0035330)2.99553589
26nonmotile primary cilium assembly (GO:0035058)2.96601052
27detection of light stimulus involved in sensory perception (GO:0050962)2.95122679
28detection of light stimulus involved in visual perception (GO:0050908)2.95122679
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.94791149
30mitochondrial respiratory chain complex I assembly (GO:0032981)2.94791149
31NADH dehydrogenase complex assembly (GO:0010257)2.94791149
32reflex (GO:0060004)2.92493828
33negative regulation of transcription regulatory region DNA binding (GO:2000678)2.92096282
34cell proliferation in forebrain (GO:0021846)2.92012837
35negative regulation of systemic arterial blood pressure (GO:0003085)2.91373734
36gamma-aminobutyric acid transport (GO:0015812)2.86726841
37cellular response to ATP (GO:0071318)2.84747010
38protein complex biogenesis (GO:0070271)2.82856765
39limb bud formation (GO:0060174)2.82291555
40cornea development in camera-type eye (GO:0061303)2.79827942
41negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.78277017
42negative regulation of translation, ncRNA-mediated (GO:0040033)2.78277017
43regulation of translation, ncRNA-mediated (GO:0045974)2.78277017
44establishment of protein localization to mitochondrial membrane (GO:0090151)2.73852215
45mitochondrial respiratory chain complex assembly (GO:0033108)2.69014061
46G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.68502301
47somatic hypermutation of immunoglobulin genes (GO:0016446)2.67973437
48somatic diversification of immune receptors via somatic mutation (GO:0002566)2.67973437
49replication fork processing (GO:0031297)2.67564476
50recombinational repair (GO:0000725)2.66905844
51artery development (GO:0060840)2.65983795
52regulation of telomere maintenance (GO:0032204)2.65471331
53cilium morphogenesis (GO:0060271)2.65320484
54negative regulation of cytosolic calcium ion concentration (GO:0051481)2.64668511
55double-strand break repair via homologous recombination (GO:0000724)2.63191926
56spinal cord motor neuron differentiation (GO:0021522)2.62878500
57indole-containing compound metabolic process (GO:0042430)2.61662810
58transmission of nerve impulse (GO:0019226)2.61195959
59epithelial cilium movement (GO:0003351)2.60511846
60neuronal action potential (GO:0019228)2.60144967
61neural tube formation (GO:0001841)2.59734872
62axoneme assembly (GO:0035082)2.58271819
63RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.56942547
64regulation of rhodopsin mediated signaling pathway (GO:0022400)2.56310498
65energy coupled proton transport, down electrochemical gradient (GO:0015985)2.56288461
66ATP synthesis coupled proton transport (GO:0015986)2.56288461
67hindbrain development (GO:0030902)2.54832873
68mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.54486076
69preassembly of GPI anchor in ER membrane (GO:0016254)2.52167408
70pyrimidine nucleobase catabolic process (GO:0006208)2.50957465
71negative regulation of DNA-dependent DNA replication (GO:2000104)2.50576416
72rhodopsin mediated signaling pathway (GO:0016056)2.50455295
73regulation of action potential (GO:0098900)2.49662384
74nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.49596969
75cellular ketone body metabolic process (GO:0046950)2.47951452
76photoreceptor cell development (GO:0042461)2.46416180
77DNA demethylation (GO:0080111)2.45647234
78reciprocal meiotic recombination (GO:0007131)2.45556463
79reciprocal DNA recombination (GO:0035825)2.45556463
80protein localization to cilium (GO:0061512)2.45259891
81photoreceptor cell maintenance (GO:0045494)2.44921736
82cilium organization (GO:0044782)2.43936573
83mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.43661781
84pituitary gland development (GO:0021983)2.43319699
85amine catabolic process (GO:0009310)2.43031759
86cellular biogenic amine catabolic process (GO:0042402)2.43031759
87nephron tubule morphogenesis (GO:0072078)2.42406873
88nephron epithelium morphogenesis (GO:0072088)2.42406873
89peristalsis (GO:0030432)2.42170236
90negative regulation of mast cell activation (GO:0033004)2.40750407
91otic vesicle formation (GO:0030916)2.39199980
92protein-cofactor linkage (GO:0018065)2.37732413
93regulation of nuclear cell cycle DNA replication (GO:0033262)2.36880235
94exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.36837815
95respiratory chain complex IV assembly (GO:0008535)2.36539674
96cilium assembly (GO:0042384)2.36456933
97negative regulation of response to food (GO:0032096)2.35919398
98negative regulation of appetite (GO:0032099)2.35919398
99head development (GO:0060322)2.33352751
100serotonin metabolic process (GO:0042428)2.32916038

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.64718278
2EZH2_22144423_ChIP-Seq_EOC_Human3.33424120
3VDR_22108803_ChIP-Seq_LS180_Human3.30782166
4GBX2_23144817_ChIP-Seq_PC3_Human2.87714689
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.57735833
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.55943148
7IGF1R_20145208_ChIP-Seq_DFB_Human2.49033942
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.42458335
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.42277995
10EWS_26573619_Chip-Seq_HEK293_Human2.35425421
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.27643866
12FUS_26573619_Chip-Seq_HEK293_Human2.25120890
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.23165370
14TAF15_26573619_Chip-Seq_HEK293_Human2.17603307
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.17084981
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.10492480
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.09355863
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.09240197
19P300_19829295_ChIP-Seq_ESCs_Human2.05134113
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.94281227
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.92192494
22* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.90552924
23IRF1_19129219_ChIP-ChIP_H3396_Human1.78423585
24ER_23166858_ChIP-Seq_MCF-7_Human1.75395200
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.71739605
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71539545
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.67103312
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.65329515
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.59401693
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56683348
31CBP_20019798_ChIP-Seq_JUKART_Human1.56357722
32IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56357722
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.56137755
34BCAT_22108803_ChIP-Seq_LS180_Human1.55435879
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52176236
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51693776
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49939185
38SMAD4_21799915_ChIP-Seq_A2780_Human1.49490522
39SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48578716
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.47929286
41MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47029527
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46837819
43POU5F1_16153702_ChIP-ChIP_HESCs_Human1.46005340
44TP53_22573176_ChIP-Seq_HFKS_Human1.45272207
45STAT3_23295773_ChIP-Seq_U87_Human1.43058068
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42817794
47GABP_17652178_ChIP-ChIP_JURKAT_Human1.41621002
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41402628
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.41402628
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41032672
51AR_25329375_ChIP-Seq_VCAP_Human1.39710184
52* TCF4_23295773_ChIP-Seq_U87_Human1.37724300
53NR3C1_21868756_ChIP-Seq_MCF10A_Human1.36507213
54AR_21572438_ChIP-Seq_LNCaP_Human1.33988447
55RNF2_27304074_Chip-Seq_NSC_Mouse1.33653313
56PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33129183
57MYC_18940864_ChIP-ChIP_HL60_Human1.33074161
58E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.32896216
59EST1_17652178_ChIP-ChIP_JURKAT_Human1.31679037
60TCF4_22108803_ChIP-Seq_LS180_Human1.30059657
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.29900611
62GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27639385
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.25985620
64REST_21632747_ChIP-Seq_MESCs_Mouse1.23705821
65NANOG_19829295_ChIP-Seq_ESCs_Human1.23308069
66SOX2_19829295_ChIP-Seq_ESCs_Human1.23308069
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21753683
68SMAD4_21741376_ChIP-Seq_EPCs_Human1.21591626
69RUNX2_22187159_ChIP-Seq_PCA_Human1.19280507
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18218743
71EED_16625203_ChIP-ChIP_MESCs_Mouse1.17771654
72ELK1_19687146_ChIP-ChIP_HELA_Human1.17686340
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15390532
74KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15016874
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.14287314
76NFE2_27457419_Chip-Seq_LIVER_Mouse1.14259601
77NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12812903
78EZH2_27304074_Chip-Seq_ESCs_Mouse1.11398186
79FOXA1_25329375_ChIP-Seq_VCAP_Human1.11137683
80FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11137683
81PRDM14_20953172_ChIP-Seq_ESCs_Human1.10851712
82FLI1_21867929_ChIP-Seq_TH2_Mouse1.10811419
83KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.10520465
84EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09793368
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05056635
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.03870255
87TP63_19390658_ChIP-ChIP_HaCaT_Human1.02607204
88GATA3_21878914_ChIP-Seq_MCF-7_Human1.02237782
89FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02165670
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01041037
91HOXB7_26014856_ChIP-Seq_BT474_Human1.00737256
92CRX_20693478_ChIP-Seq_RETINA_Mouse0.99849230
93CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99354176
94JUN_21703547_ChIP-Seq_K562_Human0.98364260
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97774677
96JARID2_20064375_ChIP-Seq_MESCs_Mouse0.97735548
97P53_22387025_ChIP-Seq_ESCs_Mouse0.97580548
98TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.97361785
99NCOR_22424771_ChIP-Seq_293T_Human0.96913077
100KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96068990

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode2.90331812
2MP0008877_abnormal_DNA_methylation2.87390204
3MP0003136_yellow_coat_color2.48680001
4MP0003195_calcinosis2.43756956
5MP0006072_abnormal_retinal_apoptosis2.35362160
6MP0005551_abnormal_eye_electrophysiolog2.31450809
7MP0002102_abnormal_ear_morphology2.27860238
8MP0002638_abnormal_pupillary_reflex2.18979517
9MP0001968_abnormal_touch/_nociception2.09429119
10MP0004145_abnormal_muscle_electrophysio2.02987558
11MP0008872_abnormal_physiological_respon2.02327689
12MP0002837_dystrophic_cardiac_calcinosis1.98572122
13MP0002938_white_spotting1.96924576
14MP0003890_abnormal_embryonic-extraembry1.87654873
15MP0003646_muscle_fatigue1.85142874
16MP0004885_abnormal_endolymph1.84062193
17MP0000631_abnormal_neuroendocrine_gland1.82403472
18MP0005646_abnormal_pituitary_gland1.82295729
19MP0004133_heterotaxia1.82124361
20MP0001485_abnormal_pinna_reflex1.80181218
21MP0004147_increased_porphyrin_level1.75923971
22MP0005253_abnormal_eye_physiology1.71540338
23MP0003880_abnormal_central_pattern1.70605240
24MP0003787_abnormal_imprinting1.69907652
25MP0002736_abnormal_nociception_after1.69709795
26MP0002876_abnormal_thyroid_physiology1.67772023
27MP0009046_muscle_twitch1.62320539
28MP0004142_abnormal_muscle_tone1.61702019
29MP0002653_abnormal_ependyma_morphology1.59867555
30MP0009745_abnormal_behavioral_response1.58270580
31MP0002735_abnormal_chemical_nociception1.58007029
32MP0006276_abnormal_autonomic_nervous1.54722248
33MP0000569_abnormal_digit_pigmentation1.50243746
34MP0002272_abnormal_nervous_system1.48904147
35MP0001984_abnormal_olfaction1.43743194
36MP0002163_abnormal_gland_morphology1.42152195
37MP0001486_abnormal_startle_reflex1.42079693
38MP0003119_abnormal_digestive_system1.38746624
39MP0003937_abnormal_limbs/digits/tail_de1.38472153
40MP0008995_early_reproductive_senescence1.38143389
41MP0000049_abnormal_middle_ear1.36546479
42MP0001986_abnormal_taste_sensitivity1.34577135
43MP0003011_delayed_dark_adaptation1.33895967
44MP0002160_abnormal_reproductive_system1.31267351
45MP0000372_irregular_coat_pigmentation1.31171989
46MP0000383_abnormal_hair_follicle1.31124535
47MP0002734_abnormal_mechanical_nocicepti1.24066821
48MP0000427_abnormal_hair_cycle1.23901694
49MP0002557_abnormal_social/conspecific_i1.23361031
50MP0001293_anophthalmia1.21760476
51MP0004215_abnormal_myocardial_fiber1.20448751
52MP0001970_abnormal_pain_threshold1.19704558
53MP0002733_abnormal_thermal_nociception1.18298904
54MP0004043_abnormal_pH_regulation1.17814500
55MP0010386_abnormal_urinary_bladder1.15636416
56MP0005389_reproductive_system_phenotype1.12718566
57MP0002751_abnormal_autonomic_nervous1.12002113
58MP0003283_abnormal_digestive_organ1.11593414
59MP0000778_abnormal_nervous_system1.11568250
60MP0005645_abnormal_hypothalamus_physiol1.10578418
61MP0001529_abnormal_vocalization1.09425782
62MP0005084_abnormal_gallbladder_morpholo1.09419696
63MP0002928_abnormal_bile_duct1.09068941
64MP0008789_abnormal_olfactory_epithelium1.08773320
65MP0002572_abnormal_emotion/affect_behav1.08672971
66MP0005195_abnormal_posterior_eye1.06286375
67MP0003567_abnormal_fetal_cardiomyocyte1.05800046
68MP0003718_maternal_effect1.05427071
69MP0005379_endocrine/exocrine_gland_phen1.04322561
70MP0004742_abnormal_vestibular_system1.02745595
71MP0000026_abnormal_inner_ear1.02729720
72MP0005174_abnormal_tail_pigmentation1.01880541
73MP0008875_abnormal_xenobiotic_pharmacok1.00056806
74MP0003938_abnormal_ear_development0.99249195
75MP0002064_seizures0.98361725
76MP0002752_abnormal_somatic_nervous0.98063068
77MP0002234_abnormal_pharynx_morphology0.98010676
78MP0002067_abnormal_sensory_capabilities0.97381767
79MP0001501_abnormal_sleep_pattern0.96879273
80MP0004924_abnormal_behavior0.94138687
81MP0005386_behavior/neurological_phenoty0.94138687
82MP0001919_abnormal_reproductive_system0.93093369
83MP0003121_genomic_imprinting0.93088569
84MP0003137_abnormal_impulse_conducting0.93055838
85MP0008775_abnormal_heart_ventricle0.91703092
86MP0000230_abnormal_systemic_arterial0.91258873
87MP0002184_abnormal_innervation0.87417296
88MP0005391_vision/eye_phenotype0.87196677
89MP0001286_abnormal_eye_development0.85659934
90MP0000647_abnormal_sebaceous_gland0.85319363
91MP0008058_abnormal_DNA_repair0.85281168
92MP0002254_reproductive_system_inflammat0.82138488
93MP0001440_abnormal_grooming_behavior0.81926261
94MP0009697_abnormal_copulation0.81327130
95MP0002063_abnormal_learning/memory/cond0.80604729
96MP0004085_abnormal_heartbeat0.80047583
97MP0003635_abnormal_synaptic_transmissio0.79565167
98MP0001963_abnormal_hearing_physiology0.79238664
99MP0003122_maternal_imprinting0.79212948
100MP0005394_taste/olfaction_phenotype0.76515560

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.45720998
2Pancreatic fibrosis (HP:0100732)3.93505113
3True hermaphroditism (HP:0010459)3.82601710
4Abnormality of midbrain morphology (HP:0002418)3.67901723
5Molar tooth sign on MRI (HP:0002419)3.67901723
6Congenital stationary night blindness (HP:0007642)3.57096937
7Nephronophthisis (HP:0000090)3.51401724
8Abnormality of the renal cortex (HP:0011035)3.09293103
9Abnormality of the renal medulla (HP:0100957)3.07810902
10Pendular nystagmus (HP:0012043)2.89182007
11Type II lissencephaly (HP:0007260)2.88271415
12Congenital, generalized hypertrichosis (HP:0004540)2.86854133
13Hyperventilation (HP:0002883)2.82154264
14Cystic liver disease (HP:0006706)2.76759261
15Genetic anticipation (HP:0003743)2.73636855
16Abolished electroretinogram (ERG) (HP:0000550)2.73131063
17Medial flaring of the eyebrow (HP:0010747)2.69118907
18Progressive cerebellar ataxia (HP:0002073)2.54045344
19Renal cortical cysts (HP:0000803)2.51793937
20Chronic hepatic failure (HP:0100626)2.51110527
21Tubular atrophy (HP:0000092)2.48605941
22Aplasia/Hypoplasia of the tibia (HP:0005772)2.36695257
23Keratoconus (HP:0000563)2.33964179
24Increased corneal curvature (HP:0100692)2.33964179
25Chorioretinal atrophy (HP:0000533)2.30478443
26Abnormal rod and cone electroretinograms (HP:0008323)2.30378723
27Attenuation of retinal blood vessels (HP:0007843)2.30252583
28Cerebellar dysplasia (HP:0007033)2.29171101
29Sclerocornea (HP:0000647)2.28432973
30Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.28094550
31Optic nerve hypoplasia (HP:0000609)2.27243999
32Methylmalonic acidemia (HP:0002912)2.26933791
33Genital tract atresia (HP:0001827)2.26908357
34Vaginal atresia (HP:0000148)2.24204619
35Gaze-evoked nystagmus (HP:0000640)2.22907360
36Furrowed tongue (HP:0000221)2.19740573
37Gait imbalance (HP:0002141)2.19474133
38Patellar aplasia (HP:0006443)2.19016249
39Congenital primary aphakia (HP:0007707)2.17157179
40Aplasia/Hypoplasia of the patella (HP:0006498)2.16828031
41Congenital hepatic fibrosis (HP:0002612)2.15313673
42Broad-based gait (HP:0002136)2.15146013
43Abnormality of the renal collecting system (HP:0004742)2.14537456
44Hypoplasia of the pons (HP:0012110)2.13862444
45Septo-optic dysplasia (HP:0100842)2.12960492
46Aplasia/Hypoplasia of the uvula (HP:0010293)2.12945785
47Decreased central vision (HP:0007663)2.12648371
48Protruding tongue (HP:0010808)2.12506968
49Anencephaly (HP:0002323)2.11771040
50Concave nail (HP:0001598)2.11150762
51Inability to walk (HP:0002540)2.08856557
52Male pseudohermaphroditism (HP:0000037)2.08565468
53Bilateral microphthalmos (HP:0007633)2.05552842
54Abnormality of the pons (HP:0007361)2.03835700
55Nephrogenic diabetes insipidus (HP:0009806)2.03417559
56Abnormality of alanine metabolism (HP:0010916)2.02912122
57Hyperalaninemia (HP:0003348)2.02912122
58Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.02912122
59Aplasia/Hypoplasia of the spleen (HP:0010451)2.01803411
60Abnormal drinking behavior (HP:0030082)2.01722783
61Polydipsia (HP:0001959)2.01722783
62Abnormality of the ileum (HP:0001549)2.00874009
63Aplasia/Hypoplasia of the tongue (HP:0010295)1.99067351
64Duplicated collecting system (HP:0000081)1.98444305
65Colon cancer (HP:0003003)1.97101644
66Absent rod-and cone-mediated responses on ERG (HP:0007688)1.96934507
67Postaxial foot polydactyly (HP:0001830)1.94795506
68Lissencephaly (HP:0001339)1.94760364
69Large for gestational age (HP:0001520)1.94350780
70Abnormality of the labia minora (HP:0012880)1.93017814
71Meckel diverticulum (HP:0002245)1.92544267
72Methylmalonic aciduria (HP:0012120)1.91537097
73Thyroid-stimulating hormone excess (HP:0002925)1.89742814
74Absent thumb (HP:0009777)1.89553283
75Intestinal atresia (HP:0011100)1.86308227
76Asplenia (HP:0001746)1.86144466
77Short tibia (HP:0005736)1.85607931
78Small hand (HP:0200055)1.84925483
79Poor coordination (HP:0002370)1.81387047
80Mitochondrial inheritance (HP:0001427)1.80001729
81Acute necrotizing encephalopathy (HP:0006965)1.78722727
82Short hallux (HP:0010109)1.77004734
83Decreased circulating renin level (HP:0003351)1.76584726
84Clumsiness (HP:0002312)1.73618295
85Chromsome breakage (HP:0040012)1.72936392
86Aplasia/Hypoplasia of the hallux (HP:0008362)1.71953674
873-Methylglutaconic aciduria (HP:0003535)1.71518021
88Rib fusion (HP:0000902)1.71396850
89Bile duct proliferation (HP:0001408)1.71379746
90Abnormal biliary tract physiology (HP:0012439)1.71379746
91Dandy-Walker malformation (HP:0001305)1.71327278
92Agitation (HP:0000713)1.71236162
93Bony spicule pigmentary retinopathy (HP:0007737)1.70914861
94Hemiparesis (HP:0001269)1.70907469
95Birth length less than 3rd percentile (HP:0003561)1.70630202
96Abnormality of chromosome stability (HP:0003220)1.70340014
97Chromosomal breakage induced by crosslinking agents (HP:0003221)1.70020087
98Aplasia/Hypoplasia of the fovea (HP:0008060)1.68571396
99Hypoplasia of the fovea (HP:0007750)1.68571396
100Aplasia/hypoplasia of the uterus (HP:0008684)1.68004546

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.80273002
2BMPR1B3.49496986
3ADRBK23.08345003
4GRK12.80982333
5ZAK2.74950464
6TAOK32.67388974
7WNK32.61228154
8ACVR1B2.59990880
9NUAK12.27075440
10MAP4K22.13287431
11CASK2.08548604
12INSRR2.07760829
13WNK42.06619432
14TLK12.00798983
15MKNK21.93763368
16PINK11.90582450
17TXK1.87772660
18TNIK1.83551324
19MAPK131.69640181
20MAP3K41.64938102
21BRSK21.48662429
22OXSR11.38834122
23STK391.33566468
24PNCK1.31665079
25MAPK151.26428631
26VRK11.22093971
27TGFBR11.19850241
28WEE11.16866233
29DYRK21.14723579
30DAPK21.14471717
31MKNK11.13802972
32TAF11.12271880
33PLK41.07271391
34VRK21.04806068
35AKT30.97612150
36TIE10.96376931
37ADRBK10.96107446
38PAK30.94085196
39MARK10.93637966
40PRKCG0.92124479
41PRKCE0.90941261
42NTRK30.88109431
43NLK0.85571060
44NME10.83624559
45CSNK1G10.81878765
46STK38L0.80032476
47NEK20.78066669
48TRIM280.77857856
49FLT30.76210767
50PLK30.75228792
51FGFR20.74978503
52OBSCN0.71147840
53CDC70.70089949
54CSNK1G20.69347051
55MUSK0.69192204
56LATS10.69138455
57MAP2K70.67021321
58STK30.63998529
59CSNK1G30.62238332
60CSNK1A1L0.60599997
61ATR0.60255221
62PLK20.59543300
63PIK3CA0.56654669
64PTK2B0.55510363
65MST40.53945082
66CAMKK20.51213918
67TEC0.50936084
68BCKDK0.50905813
69STK110.49249631
70MAP2K60.49020915
71SGK20.48947514
72RPS6KA50.48497218
73CSNK1A10.47225117
74CAMK2A0.47170798
75CDK30.46659974
76CHEK20.43268478
77NTRK20.43098846
78BCR0.42393315
79PRKACA0.41892916
80CAMK10.40939732
81PASK0.40624593
82CSNK1D0.40399837
83ERBB20.39943256
84STK160.39772100
85KIT0.39758981
86MAPKAPK50.39288334
87EPHA40.39113091
88PHKG20.38692098
89PHKG10.38692098
90PRKCQ0.38385420
91GRK70.37715365
92ATM0.37186277
93PKN10.36957537
94PLK10.36063398
95TSSK60.34941157
96SRPK10.34817115
97WNK10.33771258
98SGK2230.31548972
99SGK4940.31548972
100MAPKAPK30.31306719

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.77716554
2Homologous recombination_Homo sapiens_hsa034402.51123519
3Oxidative phosphorylation_Homo sapiens_hsa001902.44616699
4Selenocompound metabolism_Homo sapiens_hsa004502.36359971
5Linoleic acid metabolism_Homo sapiens_hsa005912.32974047
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.28533849
7Protein export_Homo sapiens_hsa030602.19513279
8Fanconi anemia pathway_Homo sapiens_hsa034602.15808802
9Nicotine addiction_Homo sapiens_hsa050332.15110627
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.14650888
11Nitrogen metabolism_Homo sapiens_hsa009102.08060025
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.04260216
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.96416199
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.95563113
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.92510231
16Parkinsons disease_Homo sapiens_hsa050121.91052374
17Ether lipid metabolism_Homo sapiens_hsa005651.83304534
18RNA polymerase_Homo sapiens_hsa030201.76620683
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.74354019
20Basal transcription factors_Homo sapiens_hsa030221.67493530
21Butanoate metabolism_Homo sapiens_hsa006501.61685067
22RNA degradation_Homo sapiens_hsa030181.56147847
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54792818
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.50645007
25Cardiac muscle contraction_Homo sapiens_hsa042601.47956335
26Tryptophan metabolism_Homo sapiens_hsa003801.45883972
27Taste transduction_Homo sapiens_hsa047421.45591968
28Ribosome_Homo sapiens_hsa030101.37315073
29Huntingtons disease_Homo sapiens_hsa050161.35952875
30Caffeine metabolism_Homo sapiens_hsa002321.32632495
31Alzheimers disease_Homo sapiens_hsa050101.30277865
32Olfactory transduction_Homo sapiens_hsa047401.29755756
33Propanoate metabolism_Homo sapiens_hsa006401.29511693
34One carbon pool by folate_Homo sapiens_hsa006701.29028564
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.27320802
36Morphine addiction_Homo sapiens_hsa050321.24151708
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.15118166
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07820738
39Serotonergic synapse_Homo sapiens_hsa047261.05772088
40Chemical carcinogenesis_Homo sapiens_hsa052041.05435150
41Circadian entrainment_Homo sapiens_hsa047131.04606045
42Glutamatergic synapse_Homo sapiens_hsa047241.04049331
43GABAergic synapse_Homo sapiens_hsa047271.02818197
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.01596089
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.01001450
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.00794896
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00668978
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98381051
49Asthma_Homo sapiens_hsa053100.95583886
50Regulation of autophagy_Homo sapiens_hsa041400.95427841
51Non-homologous end-joining_Homo sapiens_hsa034500.93644711
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.92857987
53Hedgehog signaling pathway_Homo sapiens_hsa043400.92820649
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91549764
55Insulin secretion_Homo sapiens_hsa049110.91514735
56Basal cell carcinoma_Homo sapiens_hsa052170.90664946
57Sulfur metabolism_Homo sapiens_hsa009200.89761690
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86883716
59Vitamin digestion and absorption_Homo sapiens_hsa049770.82230106
60Mismatch repair_Homo sapiens_hsa034300.79117643
61Retinol metabolism_Homo sapiens_hsa008300.78582768
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76218157
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.75855703
64Nucleotide excision repair_Homo sapiens_hsa034200.74845748
65Ovarian steroidogenesis_Homo sapiens_hsa049130.73559965
66Arachidonic acid metabolism_Homo sapiens_hsa005900.73421759
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.71565541
68Peroxisome_Homo sapiens_hsa041460.71028276
69Purine metabolism_Homo sapiens_hsa002300.69520634
70Fat digestion and absorption_Homo sapiens_hsa049750.69425141
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67790558
72Calcium signaling pathway_Homo sapiens_hsa040200.64693086
73Salivary secretion_Homo sapiens_hsa049700.64587377
74Glycerolipid metabolism_Homo sapiens_hsa005610.64298638
75Mineral absorption_Homo sapiens_hsa049780.62276491
76ABC transporters_Homo sapiens_hsa020100.62177435
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57234570
78Proteasome_Homo sapiens_hsa030500.56623993
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55513871
80Cocaine addiction_Homo sapiens_hsa050300.54637875
81Circadian rhythm_Homo sapiens_hsa047100.54048269
82RNA transport_Homo sapiens_hsa030130.51666777
83Dopaminergic synapse_Homo sapiens_hsa047280.51613024
84Metabolic pathways_Homo sapiens_hsa011000.51229634
85Type I diabetes mellitus_Homo sapiens_hsa049400.48331004
86Pyrimidine metabolism_Homo sapiens_hsa002400.48010760
87Primary immunodeficiency_Homo sapiens_hsa053400.46978657
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.45585230
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44786688
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42133537
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41756485
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.41439721
93Cholinergic synapse_Homo sapiens_hsa047250.41292178
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41139698
95Amphetamine addiction_Homo sapiens_hsa050310.40080479
96cAMP signaling pathway_Homo sapiens_hsa040240.39706756
97TGF-beta signaling pathway_Homo sapiens_hsa043500.39642674
98Long-term depression_Homo sapiens_hsa047300.39542114
99Hippo signaling pathway_Homo sapiens_hsa043900.37353608
100Histidine metabolism_Homo sapiens_hsa003400.37223863

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