ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of helicase activity (GO:0051095)	4.91376590
2	somatic diversification of immune receptors via somatic mutation (GO:0002566)	4.55027738
3	somatic hypermutation of immunoglobulin genes (GO:0016446)	4.55027738
4	protein-cofactor linkage (GO:0018065)	4.24063586
5	DNA double-strand break processing (GO:0000729)	4.19015376
6	UDP-N-acetylglucosamine metabolic process (GO:0006047)	3.87945514
7	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.83730289
8	cullin deneddylation (GO:0010388)	3.77789038
9	platelet dense granule organization (GO:0060155)	3.68426086
10	regulation of hexokinase activity (GO:1903299)	3.62922500
11	regulation of glucokinase activity (GO:0033131)	3.62922500
12	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.57833540
13	behavioral response to nicotine (GO:0035095)	3.48884491
14	response to pheromone (GO:0019236)	3.46147096
15	regulation of mitotic spindle checkpoint (GO:1903504)	3.35461566
16	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.35461566
17	water-soluble vitamin biosynthetic process (GO:0042364)	3.34733610
18	resolution of meiotic recombination intermediates (GO:0000712)	3.33298754
19	regulation of DNA endoreduplication (GO:0032875)	3.28023589
20	synapsis (GO:0007129)	3.25693372
21	protein deneddylation (GO:0000338)	3.25686241
22	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	3.20115464
23	negative regulation of DNA recombination (GO:0045910)	3.18341494
24	presynaptic membrane assembly (GO:0097105)	3.16108168
25	female gonad development (GO:0008585)	3.14557954
26	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.12837037
27	mannosylation (GO:0097502)	3.10007447
28	proteasome assembly (GO:0043248)	3.08421391
29	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.04843196
30	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.00612775
31	DNA replication-dependent nucleosome assembly (GO:0006335)	3.00210643
32	DNA replication-dependent nucleosome organization (GO:0034723)	3.00210643
33	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.99601050
34	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.97845049
35	ventricular cardiac muscle cell development (GO:0055015)	2.91976283
36	rRNA methylation (GO:0031167)	2.89973158
37	nephron epithelium morphogenesis (GO:0072088)	2.88108422
38	nephron tubule morphogenesis (GO:0072078)	2.88108422
39	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.87624869
40	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.87624869
41	isotype switching (GO:0045190)	2.87624869
42	prenylation (GO:0097354)	2.87112750
43	protein prenylation (GO:0018342)	2.87112750
44	kidney morphogenesis (GO:0060993)	2.86686337
45	DNA damage response, detection of DNA damage (GO:0042769)	2.85995959
46	chromatin remodeling at centromere (GO:0031055)	2.84403761
47	DNA catabolic process, exonucleolytic (GO:0000738)	2.84050966
48	pyrimidine nucleobase catabolic process (GO:0006208)	2.77628375
49	mismatch repair (GO:0006298)	2.76836071
50	rRNA modification (GO:0000154)	2.76649334
51	CENP-A containing nucleosome assembly (GO:0034080)	2.75450021
52	double-strand break repair via homologous recombination (GO:0000724)	2.69485719
53	recombinational repair (GO:0000725)	2.69057754
54	receptor guanylyl cyclase signaling pathway (GO:0007168)	2.67678889
55	lactate metabolic process (GO:0006089)	2.65638343
56	anterograde synaptic vesicle transport (GO:0048490)	2.65544584
57	regulation of meiosis I (GO:0060631)	2.64502470
58	L-fucose catabolic process (GO:0042355)	2.62553548
59	fucose catabolic process (GO:0019317)	2.62553548
60	L-fucose metabolic process (GO:0042354)	2.62553548
61	preassembly of GPI anchor in ER membrane (GO:0016254)	2.62306090
62	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.62151759
63	somatic diversification of immunoglobulins (GO:0016445)	2.56354519
64	aspartate family amino acid catabolic process (GO:0009068)	2.54881729
65	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.53999096
66	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.51175141
67	somatic recombination of immunoglobulin gene segments (GO:0016447)	2.50480532
68	peptidyl-histidine modification (GO:0018202)	2.49937996
69	photoreceptor cell maintenance (GO:0045494)	2.48602216
70	branched-chain amino acid catabolic process (GO:0009083)	2.47995899
71	presynaptic membrane organization (GO:0097090)	2.47979647
72	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.46871727
73	protein K6-linked ubiquitination (GO:0085020)	2.46604912
74	histone exchange (GO:0043486)	2.45856929
75	tRNA modification (GO:0006400)	2.44217979
76	maturation of 5.8S rRNA (GO:0000460)	2.44097932
77	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.43878670
78	somite rostral/caudal axis specification (GO:0032525)	2.43163404
79	pre-miRNA processing (GO:0031054)	2.41366080
80	histone H2A acetylation (GO:0043968)	2.40506916
81	regulation of centriole replication (GO:0046599)	2.40276428
82	DNA replication checkpoint (GO:0000076)	2.39358466
83	nucleotide-sugar biosynthetic process (GO:0009226)	2.37759757
84	aggressive behavior (GO:0002118)	2.36901451
85	ncRNA catabolic process (GO:0034661)	2.36725790
86	reciprocal meiotic recombination (GO:0007131)	2.34540774
87	reciprocal DNA recombination (GO:0035825)	2.34540774
88	lysine catabolic process (GO:0006554)	2.33082560
89	lysine metabolic process (GO:0006553)	2.33082560
90	regulation of mesoderm development (GO:2000380)	2.32917057
91	male meiosis (GO:0007140)	2.31803894
92	nucleobase catabolic process (GO:0046113)	2.31267438
93	GPI anchor metabolic process (GO:0006505)	2.30589708
94	ribonucleoprotein complex disassembly (GO:0032988)	2.28531514
95	regulation of telomere maintenance via telomerase (GO:0032210)	2.27717870
96	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.25037803
97	intraciliary transport (GO:0042073)	2.24394164
98	pituitary gland development (GO:0021983)	2.24363269
99	atrial cardiac muscle cell action potential (GO:0086014)	2.23921553
100	tRNA processing (GO:0008033)	2.21399103

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.63336361
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.50263740
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.08012663
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.07023805
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.94427105
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.63765307
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.55031885
8	FUS_26573619_Chip-Seq_HEK293_Human	2.51872278
9	GBX2_23144817_ChIP-Seq_PC3_Human	2.51691670
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.50326875
11	EWS_26573619_Chip-Seq_HEK293_Human	2.48337079
12	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.35533823
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.35015788
14	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.27231937
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.26199115
16	P300_19829295_ChIP-Seq_ESCs_Human	2.25199206
17	ELK1_19687146_ChIP-ChIP_HELA_Human	2.24862334
18	TAF15_26573619_Chip-Seq_HEK293_Human	2.24589776
19	VDR_22108803_ChIP-Seq_LS180_Human	2.16228971
20	POU5F1_16153702_ChIP-ChIP_HESCs_Human	2.15815140
21	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.09650252
22	IGF1R_20145208_ChIP-Seq_DFB_Human	2.07939841
23	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.05483441
24	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.05075555
25	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.89628816
26	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.68524906
27	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.66875047
28	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.65454975
29	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.64717877
30	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.63567454
31	E2F7_22180533_ChIP-Seq_HELA_Human	1.62896331
32	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.58104773
33	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.56933854
34	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.56185632
35	VDR_23849224_ChIP-Seq_CD4+_Human	1.50773192
36	MYC_18940864_ChIP-ChIP_HL60_Human	1.48179740
37	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.46668173
38	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.46652068
39	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.45858424
40	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.45275916
41	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.44279627
42	SMAD4_21799915_ChIP-Seq_A2780_Human	1.43991000
43	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.43977325
44	ER_23166858_ChIP-Seq_MCF-7_Human	1.43850544
45	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.41635074
46	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.40640703
47	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.40108566
48	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.38750974
49	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.32784446
50	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.30456993
51	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.26095048
52	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.25954681
53	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.25118030
54	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.24251011
55	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.22723572
56	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.22527353
57	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.19870652
58	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.19860578
59	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.19686615
60	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.18766618
61	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.18499241
62	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.17638585
63	RNF2_27304074_Chip-Seq_NSC_Mouse	1.15109269
64	NANOG_19829295_ChIP-Seq_ESCs_Human	1.14509374
65	SOX2_19829295_ChIP-Seq_ESCs_Human	1.14509374
66	BCAT_22108803_ChIP-Seq_LS180_Human	1.14015756
67	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.13702085
68	CBP_20019798_ChIP-Seq_JUKART_Human	1.12460976
69	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.12460976
70	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.12260965
71	FOXP3_21729870_ChIP-Seq_TREG_Human	1.11849201
72	AR_25329375_ChIP-Seq_VCAP_Human	1.11834307
73	IRF1_19129219_ChIP-ChIP_H3396_Human	1.11175971
74	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.10905174
75	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.10890300
76	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.10834380
77	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.10567440
78	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.10425143
79	STAT3_23295773_ChIP-Seq_U87_Human	1.09792707
80	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.09660321
81	TCF4_22108803_ChIP-Seq_LS180_Human	1.08590674
82	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.07126132
83	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.07037832
84	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.07025505
85	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.05611645
86	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04940444
87	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.04940444
88	TP53_22573176_ChIP-Seq_HFKS_Human	1.01828931
89	TCF4_23295773_ChIP-Seq_U87_Human	1.01658366
90	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.01527566
91	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.01084132
92	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.00428156
93	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.99930207
94	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99493526
95	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.99222447
96	CDX2_22108803_ChIP-Seq_LS180_Human	0.99061936
97	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.98233913
98	RUNX2_22187159_ChIP-Seq_PCA_Human	0.98112548
99	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.97798295
100	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.94292467

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	4.19422724
2	MP0008877_abnormal_DNA_methylation	3.51832989
3	MP0003890_abnormal_embryonic-extraembry	2.90347849
4	MP0003136_yellow_coat_color	2.55308779
5	MP0006072_abnormal_retinal_apoptosis	2.41151808
6	MP0003122_maternal_imprinting	2.28420909
7	MP0002837_dystrophic_cardiac_calcinosis	2.20134422
8	MP0002938_white_spotting	2.02907956
9	MP0003787_abnormal_imprinting	1.98505109
10	MP0004133_heterotaxia	1.96527480
11	MP0003937_abnormal_limbs/digits/tail_de	1.88542816
12	MP0006292_abnormal_olfactory_placode	1.88242075
13	MP0001293_anophthalmia	1.86209607
14	MP0003011_delayed_dark_adaptation	1.84176310
15	MP0005551_abnormal_eye_electrophysiolog	1.78469164
16	MP0003195_calcinosis	1.78143336
17	MP0005253_abnormal_eye_physiology	1.77680524
18	MP0003121_genomic_imprinting	1.75516929
19	MP0003941_abnormal_skin_development	1.73964192
20	MP0002751_abnormal_autonomic_nervous	1.70594058
21	MP0003693_abnormal_embryo_hatching	1.67408082
22	MP0004957_abnormal_blastocyst_morpholog	1.62473922
23	MP0008007_abnormal_cellular_replicative	1.62290121
24	MP0008058_abnormal_DNA_repair	1.61722688
25	MP0002139_abnormal_hepatobiliary_system	1.61282635
26	MP0003137_abnormal_impulse_conducting	1.60796110
27	MP0000647_abnormal_sebaceous_gland	1.53138397
28	MP0000631_abnormal_neuroendocrine_gland	1.51884645
29	MP0003718_maternal_effect	1.51584001
30	MP0002254_reproductive_system_inflammat	1.50661365
31	MP0008057_abnormal_DNA_replication	1.49056045
32	MP0004142_abnormal_muscle_tone	1.48318500
33	MP0003119_abnormal_digestive_system	1.47099892
34	MP0010094_abnormal_chromosome_stability	1.41469565
35	MP0009046_muscle_twitch	1.40999280
36	MP0001485_abnormal_pinna_reflex	1.39964782
37	MP0002090_abnormal_vision	1.31745420
38	MP0001286_abnormal_eye_development	1.31638072
39	MP0009697_abnormal_copulation	1.31050163
40	MP0003567_abnormal_fetal_cardiomyocyte	1.28582150
41	MP0000372_irregular_coat_pigmentation	1.27410533
42	MP0002638_abnormal_pupillary_reflex	1.26003282
43	MP0003880_abnormal_central_pattern	1.21271972
44	MP0010030_abnormal_orbit_morphology	1.18914600
45	MP0002736_abnormal_nociception_after	1.18521558
46	MP0005084_abnormal_gallbladder_morpholo	1.18487785
47	MP0005646_abnormal_pituitary_gland	1.16017568
48	MP0001984_abnormal_olfaction	1.15278150
49	MP0003186_abnormal_redox_activity	1.11191878
50	MP0001486_abnormal_startle_reflex	1.09146023
51	MP0005377_hearing/vestibular/ear_phenot	1.08622069
52	MP0003878_abnormal_ear_physiology	1.08622069
53	MP0003077_abnormal_cell_cycle	1.08094994
54	MP0003786_premature_aging	1.04739786
55	MP0006276_abnormal_autonomic_nervous	1.03925622
56	MP0005187_abnormal_penis_morphology	1.02343336
57	MP0002272_abnormal_nervous_system	1.01654750
58	MP0010234_abnormal_vibrissa_follicle	1.01527401
59	MP0002138_abnormal_hepatobiliary_system	1.00952798
60	MP0004147_increased_porphyrin_level	0.99917427
61	MP0002557_abnormal_social/conspecific_i	0.98412300
62	MP0003111_abnormal_nucleus_morphology	0.96305581
63	MP0005391_vision/eye_phenotype	0.95996756
64	MP0004145_abnormal_muscle_electrophysio	0.95070056
65	MP0001177_atelectasis	0.94048939
66	MP0002084_abnormal_developmental_patter	0.93543014
67	MP0010678_abnormal_skin_adnexa	0.92953370
68	MP0005379_endocrine/exocrine_gland_phen	0.92867240
69	MP0001324_abnormal_eye_pigmentation	0.91292603
70	MP0000516_abnormal_urinary_system	0.91239876
71	MP0005367_renal/urinary_system_phenotyp	0.91239876
72	MP0004215_abnormal_myocardial_fiber	0.90953004
73	MP0005171_absent_coat_pigmentation	0.90449724
74	MP0009703_decreased_birth_body	0.90218780
75	MP0009745_abnormal_behavioral_response	0.89593712
76	MP0001929_abnormal_gametogenesis	0.89494878
77	MP0002697_abnormal_eye_size	0.89225716
78	MP0001529_abnormal_vocalization	0.89211818
79	MP0008932_abnormal_embryonic_tissue	0.87637016
80	MP0005332_abnormal_amino_acid	0.86973059
81	MP0000653_abnormal_sex_gland	0.86444980
82	MP0003755_abnormal_palate_morphology	0.86179450
83	MP0002210_abnormal_sex_determination	0.86005206
84	MP0006035_abnormal_mitochondrial_morpho	0.83498909
85	MP0000049_abnormal_middle_ear	0.83116015
86	MP0000383_abnormal_hair_follicle	0.81863748
87	MP0005394_taste/olfaction_phenotype	0.81471963
88	MP0005499_abnormal_olfactory_system	0.81471963
89	MP0004742_abnormal_vestibular_system	0.80425599
90	MP0001145_abnormal_male_reproductive	0.79111319
91	MP0002752_abnormal_somatic_nervous	0.78144148
92	MP0002184_abnormal_innervation	0.77478046
93	MP0005408_hypopigmentation	0.77022060
94	MP0008995_early_reproductive_senescence	0.76692008
95	MP0000778_abnormal_nervous_system	0.73907954
96	MP0010307_abnormal_tumor_latency	0.73648157
97	MP0005075_abnormal_melanosome_morpholog	0.72775683
98	MP0002111_abnormal_tail_morphology	0.72507916
99	MP0005195_abnormal_posterior_eye	0.72461895
100	MP0002282_abnormal_trachea_morphology	0.71984278

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Ependymoma (HP:0002888)	4.69288283
2	Neoplasm of the adrenal cortex (HP:0100641)	4.10579117
3	Abnormality of the astrocytes (HP:0100707)	3.41626162
4	Astrocytoma (HP:0009592)	3.41626162
5	Focal motor seizures (HP:0011153)	3.41227332
6	Glioma (HP:0009733)	3.37494666
7	Neoplasm of the adrenal gland (HP:0100631)	3.18326030
8	Pancreatic fibrosis (HP:0100732)	3.18282464
9	Decreased central vision (HP:0007663)	2.95465737
10	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.89509134
11	Short tibia (HP:0005736)	2.85043826
12	Pancreatic cysts (HP:0001737)	2.84807417
13	True hermaphroditism (HP:0010459)	2.77629260
14	Increased corneal curvature (HP:0100692)	2.73344184
15	Keratoconus (HP:0000563)	2.73344184
16	Pendular nystagmus (HP:0012043)	2.70325949
17	Agnosia (HP:0010524)	2.70278866
18	Abnormality of serum amino acid levels (HP:0003112)	2.69631995
19	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.68162821
20	Hyperglycinemia (HP:0002154)	2.62500112
21	Molar tooth sign on MRI (HP:0002419)	2.59343319
22	Abnormality of midbrain morphology (HP:0002418)	2.59343319
23	Adenoma sebaceum (HP:0009720)	2.56499510
24	Angiofibromas (HP:0010615)	2.56499510
25	Medulloblastoma (HP:0002885)	2.55814785
26	Abnormal pancreas size (HP:0012094)	2.54016387
27	Rhabdomyosarcoma (HP:0002859)	2.51994897
28	Abolished electroretinogram (ERG) (HP:0000550)	2.50743775
29	Chronic hepatic failure (HP:0100626)	2.50175853
30	Dialeptic seizures (HP:0011146)	2.48304758
31	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.45255598
32	Nephronophthisis (HP:0000090)	2.43351761
33	Type II lissencephaly (HP:0007260)	2.42697619
34	Methylmalonic acidemia (HP:0002912)	2.40918305
35	Adrenal hypoplasia (HP:0000835)	2.40659563
36	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.38621359
37	Abnormality of the labia minora (HP:0012880)	2.36901355
38	Hypoplasia of the uterus (HP:0000013)	2.32936342
39	Focal seizures (HP:0007359)	2.31750139
40	Colon cancer (HP:0003003)	2.30738995
41	Aplasia/hypoplasia of the uterus (HP:0008684)	2.29955965
42	Intestinal atresia (HP:0011100)	2.27173702
43	Acute encephalopathy (HP:0006846)	2.23643275
44	Abnormality of glycine metabolism (HP:0010895)	2.23587477
45	Abnormality of serine family amino acid metabolism (HP:0010894)	2.23587477
46	Increased hepatocellular lipid droplets (HP:0006565)	2.19371166
47	Hyperglycinuria (HP:0003108)	2.16857021
48	Lipid accumulation in hepatocytes (HP:0006561)	2.16724396
49	Neoplasm of striated muscle (HP:0009728)	2.12119776
50	Methylmalonic aciduria (HP:0012120)	2.10087165
51	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.08128870
52	Supernumerary spleens (HP:0009799)	2.06851656
53	3-Methylglutaconic aciduria (HP:0003535)	2.06352214
54	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.04703536
55	Neoplasm of the colon (HP:0100273)	2.04593828
56	Proximal tubulopathy (HP:0000114)	2.04257508
57	Dandy-Walker malformation (HP:0001305)	2.03933868
58	Increased CSF lactate (HP:0002490)	2.03506105
59	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.99985372
60	Hemiparesis (HP:0001269)	1.98171639
61	Abnormal lung lobation (HP:0002101)	1.96390666
62	Abnormality of the renal medulla (HP:0100957)	1.96206436
63	Absence seizures (HP:0002121)	1.95902405
64	Neoplasm of the oral cavity (HP:0100649)	1.94612442
65	Glycosuria (HP:0003076)	1.93441255
66	Abnormality of urine glucose concentration (HP:0011016)	1.93441255
67	Abnormality of the middle phalanges of the toes (HP:0010183)	1.89213368
68	Meckel diverticulum (HP:0002245)	1.88280099
69	Abnormality of vitamin B metabolism (HP:0004340)	1.88193555
70	Abnormality of the ileum (HP:0001549)	1.87580010
71	Abnormal biliary tract physiology (HP:0012439)	1.85899934
72	Bile duct proliferation (HP:0001408)	1.85899934
73	Biliary tract neoplasm (HP:0100574)	1.85852680
74	Abnormal rod and cone electroretinograms (HP:0008323)	1.83237319
75	Acute necrotizing encephalopathy (HP:0006965)	1.82821183
76	Tubular atrophy (HP:0000092)	1.82536931
77	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.82504536
78	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.81288868
79	Medial flaring of the eyebrow (HP:0010747)	1.80438729
80	Hamartoma of the eye (HP:0010568)	1.80043317
81	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.79727602
82	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.79454747
83	Chorioretinal atrophy (HP:0000533)	1.79400097
84	Cystic liver disease (HP:0006706)	1.78646295
85	Benign neoplasm of the central nervous system (HP:0100835)	1.77899827
86	Hypoglycemic coma (HP:0001325)	1.77129537
87	Cerebellar dysplasia (HP:0007033)	1.77105977
88	Optic nerve hypoplasia (HP:0000609)	1.77088339
89	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.76370521
90	Neoplasm of the small intestine (HP:0100833)	1.76226857
91	Atonic seizures (HP:0010819)	1.76181405
92	Abnormality of the anterior horn cell (HP:0006802)	1.75000670
93	Degeneration of anterior horn cells (HP:0002398)	1.75000670
94	Occipital encephalocele (HP:0002085)	1.74925399
95	Gastrointestinal atresia (HP:0002589)	1.74797849
96	Preaxial hand polydactyly (HP:0001177)	1.71849045
97	Renal hypoplasia (HP:0000089)	1.70944584
98	Abnormality of the renal cortex (HP:0011035)	1.70913069
99	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.70689606
100	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.70689606

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	3.41633892
2	ZAK	3.26926923
3	MKNK2	2.90579587
4	EIF2AK3	2.64322933
5	NUAK1	2.58030689
6	VRK2	2.49017418
7	FRK	2.44308972
8	TRIM28	2.36509750
9	ACVR1B	2.32942478
10	MKNK1	2.26958350
11	WNK3	2.24005127
12	BUB1	2.19976878
13	STK39	2.06840034
14	WEE1	1.95839633
15	MST4	1.87984492
16	BMPR1B	1.83917752
17	OXSR1	1.79916100
18	MAP4K2	1.70160330
19	WNK4	1.69803172
20	DYRK3	1.68337887
21	PLK3	1.65417260
22	STK16	1.62023770
23	CDC7	1.59831731
24	CSNK1G1	1.48887749
25	CSNK1G2	1.46822290
26	BCR	1.46621246
27	TSSK6	1.41088139
28	PLK2	1.39657372
29	TNIK	1.39586546
30	CASK	1.37865188
31	GRK1	1.36429775
32	VRK1	1.32419239
33	ERBB3	1.32176615
34	EPHA3	1.27321958
35	CSNK1G3	1.23459042
36	PLK4	1.23382129
37	SRPK1	1.23287437
38	CAMK1G	1.23217317
39	RPS6KA4	1.17005117
40	FER	1.15526775
41	PRKCE	1.10392192
42	PLK1	1.01836278
43	PINK1	1.00691547
44	CSNK1A1L	1.00288999
45	PAK4	0.98273155
46	TLK1	0.95504207
47	PHKG2	0.93628198
48	PHKG1	0.93628198
49	NEK1	0.93264111
50	TAF1	0.92260209
51	NME1	0.90395246
52	FGFR2	0.89246417
53	ATR	0.88614681
54	NLK	0.86273795
55	PAK3	0.85527972
56	TIE1	0.85366703
57	PBK	0.84560513
58	TTK	0.84290790
59	ADRBK2	0.83419762
60	DYRK2	0.80131200
61	EIF2AK1	0.78186334
62	PRKCG	0.77850335
63	BRSK2	0.71643168
64	ERBB4	0.70520572
65	MAPK13	0.69207649
66	MAP3K4	0.68905355
67	FLT3	0.68138843
68	STK38L	0.66076428
69	NTRK3	0.60855306
70	ATM	0.60783213
71	EIF2AK2	0.60602159
72	MINK1	0.60348489
73	MAP3K9	0.57042213
74	STK24	0.54977626
75	RPS6KA5	0.54812810
76	CSNK1D	0.46806397
77	BCKDK	0.46782664
78	RAF1	0.46261640
79	CDK3	0.45980370
80	PDK2	0.45340516
81	INSRR	0.45281871
82	BRD4	0.44268409
83	NEK2	0.44158995
84	CAMK2A	0.42155814
85	SIK3	0.42088019
86	PIM1	0.40979560
87	TGFBR1	0.40184829
88	CSNK1A1	0.39781242
89	FGFR1	0.35613671
90	PRKCI	0.34809895
91	PIK3CA	0.34655352
92	MET	0.33945497
93	LIMK1	0.33204458
94	OBSCN	0.32486581
95	CHEK2	0.31297116
96	CDK9	0.29860032
97	CSNK2A1	0.29663365
98	CAMK2D	0.29049234
99	GRK5	0.26797781
100	DAPK3	0.26739771

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	2.81440195
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.68514213
3	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.52491395
4	Proteasome_Homo sapiens_hsa03050	2.44129628
5	Propanoate metabolism_Homo sapiens_hsa00640	2.38418903
6	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.29547734
7	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.28587193
8	Mismatch repair_Homo sapiens_hsa03430	2.21895282
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.18954415
10	Phototransduction_Homo sapiens_hsa04744	2.10681615
11	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.08223039
12	Steroid biosynthesis_Homo sapiens_hsa00100	2.05303515
13	Butanoate metabolism_Homo sapiens_hsa00650	1.98987004
14	Selenocompound metabolism_Homo sapiens_hsa00450	1.96651600
15	RNA degradation_Homo sapiens_hsa03018	1.88760450
16	RNA polymerase_Homo sapiens_hsa03020	1.84650163
17	Non-homologous end-joining_Homo sapiens_hsa03450	1.77569985
18	One carbon pool by folate_Homo sapiens_hsa00670	1.69459448
19	RNA transport_Homo sapiens_hsa03013	1.67459062
20	Fatty acid elongation_Homo sapiens_hsa00062	1.62934934
21	Homologous recombination_Homo sapiens_hsa03440	1.62496397
22	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.60777976
23	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.57496513
24	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.55504852
25	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.54241921
26	Sulfur metabolism_Homo sapiens_hsa00920	1.53455556
27	Oxidative phosphorylation_Homo sapiens_hsa00190	1.50500758
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.48995876
29	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.45578340
30	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.42253093
31	Nicotine addiction_Homo sapiens_hsa05033	1.41334872
32	Basal transcription factors_Homo sapiens_hsa03022	1.37589924
33	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.35588028
34	Parkinsons disease_Homo sapiens_hsa05012	1.34166036
35	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.23678406
36	Spliceosome_Homo sapiens_hsa03040	1.23406501
37	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.22999832
38	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.18369803
39	Huntingtons disease_Homo sapiens_hsa05016	1.14244929
40	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.12013618
41	Pyruvate metabolism_Homo sapiens_hsa00620	1.10898023
42	Glutathione metabolism_Homo sapiens_hsa00480	1.06658980
43	DNA replication_Homo sapiens_hsa03030	1.04927448
44	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.04788045
45	Nitrogen metabolism_Homo sapiens_hsa00910	1.02639071
46	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.02208430
47	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.99686534
48	Taste transduction_Homo sapiens_hsa04742	0.99167210
49	Oocyte meiosis_Homo sapiens_hsa04114	0.97648547
50	Ether lipid metabolism_Homo sapiens_hsa00565	0.92261958
51	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.91304863
52	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.91167590
53	Peroxisome_Homo sapiens_hsa04146	0.89085261
54	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.88254356
55	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.87701593
56	Nucleotide excision repair_Homo sapiens_hsa03420	0.85745649
57	Fat digestion and absorption_Homo sapiens_hsa04975	0.84802924
58	Retinol metabolism_Homo sapiens_hsa00830	0.84572435
59	Cell cycle_Homo sapiens_hsa04110	0.83912907
60	p53 signaling pathway_Homo sapiens_hsa04115	0.82830504
61	Linoleic acid metabolism_Homo sapiens_hsa00591	0.82828856
62	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.82628562
63	Purine metabolism_Homo sapiens_hsa00230	0.81387694
64	Fatty acid metabolism_Homo sapiens_hsa01212	0.81114410
65	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.78907617
66	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.78486950
67	Alzheimers disease_Homo sapiens_hsa05010	0.77757024
68	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.77406574
69	Olfactory transduction_Homo sapiens_hsa04740	0.74397832
70	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.74332424
71	Chemical carcinogenesis_Homo sapiens_hsa05204	0.73939271
72	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.72940613
73	Tryptophan metabolism_Homo sapiens_hsa00380	0.72855421
74	Alcoholism_Homo sapiens_hsa05034	0.71840388
75	beta-Alanine metabolism_Homo sapiens_hsa00410	0.70320150
76	Pyrimidine metabolism_Homo sapiens_hsa00240	0.67962472
77	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.67775638
78	Metabolic pathways_Homo sapiens_hsa01100	0.67503744
79	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.67033087
80	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.66263757
81	Carbon metabolism_Homo sapiens_hsa01200	0.65675706
82	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.65474801
83	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.64991222
84	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.62637744
85	Fatty acid degradation_Homo sapiens_hsa00071	0.62125217
86	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.61126129
87	Base excision repair_Homo sapiens_hsa03410	0.58587035
88	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.56592257
89	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.55724901
90	Hippo signaling pathway_Homo sapiens_hsa04390	0.54829865
91	Basal cell carcinoma_Homo sapiens_hsa05217	0.50942411
92	Caffeine metabolism_Homo sapiens_hsa00232	0.49327837
93	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.47812467
94	Sulfur relay system_Homo sapiens_hsa04122	0.46625996
95	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.42648053
96	Folate biosynthesis_Homo sapiens_hsa00790	0.40834930
97	mRNA surveillance pathway_Homo sapiens_hsa03015	0.40193554
98	Lysine degradation_Homo sapiens_hsa00310	0.38335088
99	Protein digestion and absorption_Homo sapiens_hsa04974	0.34943199
100	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.34075859

ZNF322P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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