ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.32782589
2	neural tube formation (GO:0001841)	4.51819982
3	L-fucose catabolic process (GO:0042355)	4.23474614
4	fucose catabolic process (GO:0019317)	4.23474614
5	L-fucose metabolic process (GO:0042354)	4.23474614
6	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.91952425
7	regulation of translation, ncRNA-mediated (GO:0045974)	3.91952425
8	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.91952425
9	presynaptic membrane assembly (GO:0097105)	3.79303980
10	piRNA metabolic process (GO:0034587)	3.76838656
11	kidney morphogenesis (GO:0060993)	3.71029897
12	pyrimidine nucleobase catabolic process (GO:0006208)	3.70069743
13	limb bud formation (GO:0060174)	3.63633955
14	regulation of hippo signaling (GO:0035330)	3.40423141
15	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.39755917
16	somite development (GO:0061053)	3.32787816
17	nonmotile primary cilium assembly (GO:0035058)	3.31459528
18	presynaptic membrane organization (GO:0097090)	3.29682412
19	protein localization to cilium (GO:0061512)	3.23484506
20	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.20277629
21	gamma-aminobutyric acid transport (GO:0015812)	3.17991460
22	postsynaptic membrane organization (GO:0001941)	3.16918393
23	retinal cone cell development (GO:0046549)	3.14511667
24	DNA methylation involved in gamete generation (GO:0043046)	3.12582376
25	peristalsis (GO:0030432)	3.10297667
26	indolalkylamine metabolic process (GO:0006586)	3.08406268
27	cornea development in camera-type eye (GO:0061303)	3.06097831
28	transmission of nerve impulse (GO:0019226)	3.06045243
29	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.05319885
30	DNA deamination (GO:0045006)	3.01724835
31	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.01283560
32	nucleobase catabolic process (GO:0046113)	3.01031055
33	cellular ketone body metabolic process (GO:0046950)	2.96227566
34	detection of light stimulus involved in sensory perception (GO:0050962)	2.91842105
35	detection of light stimulus involved in visual perception (GO:0050908)	2.91842105
36	somite rostral/caudal axis specification (GO:0032525)	2.87988388
37	protein K11-linked deubiquitination (GO:0035871)	2.84457089
38	protein localization to synapse (GO:0035418)	2.84456731
39	neuron cell-cell adhesion (GO:0007158)	2.83192911
40	reciprocal DNA recombination (GO:0035825)	2.82304895
41	reciprocal meiotic recombination (GO:0007131)	2.82304895
42	inner ear receptor stereocilium organization (GO:0060122)	2.78043522
43	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.77886629
44	embryonic epithelial tube formation (GO:0001838)	2.75484011
45	cilium morphogenesis (GO:0060271)	2.74317017
46	regulation of gene silencing by RNA (GO:0060966)	2.72173330
47	regulation of posttranscriptional gene silencing (GO:0060147)	2.72173330
48	regulation of gene silencing by miRNA (GO:0060964)	2.72173330
49	reflex (GO:0060004)	2.71464515
50	kynurenine metabolic process (GO:0070189)	2.70769898
51	atrial cardiac muscle cell action potential (GO:0086014)	2.69262804
52	intraciliary transport (GO:0042073)	2.69127353
53	glycerophospholipid catabolic process (GO:0046475)	2.69081539
54	epithelial cilium movement (GO:0003351)	2.68963071
55	cilium organization (GO:0044782)	2.68684343
56	tryptophan catabolic process (GO:0006569)	2.67750369
57	indole-containing compound catabolic process (GO:0042436)	2.67750369
58	indolalkylamine catabolic process (GO:0046218)	2.67750369
59	neuronal action potential (GO:0019228)	2.67555867
60	phasic smooth muscle contraction (GO:0014821)	2.67414788
61	cilium assembly (GO:0042384)	2.65381829
62	ketone body metabolic process (GO:1902224)	2.63113992
63	epithelial tube formation (GO:0072175)	2.61259626
64	tryptophan metabolic process (GO:0006568)	2.60348178
65	protein polyglutamylation (GO:0018095)	2.60161234
66	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.57817689
67	photoreceptor cell development (GO:0042461)	2.56581743
68	behavioral response to ethanol (GO:0048149)	2.55893373
69	cilium or flagellum-dependent cell motility (GO:0001539)	2.55533814
70	response to pheromone (GO:0019236)	2.55432250
71	centriole replication (GO:0007099)	2.53611080
72	startle response (GO:0001964)	2.52905314
73	regulation of cilium movement (GO:0003352)	2.52339685
74	olfactory bulb development (GO:0021772)	2.50922810
75	negative regulation of telomere maintenance (GO:0032205)	2.50113798
76	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.45342811
77	prenylation (GO:0097354)	2.44972984
78	protein prenylation (GO:0018342)	2.44972984
79	regulation of telomere maintenance (GO:0032204)	2.44525826
80	establishment of protein localization to Golgi (GO:0072600)	2.44322701
81	water-soluble vitamin biosynthetic process (GO:0042364)	2.44212315
82	spinal cord development (GO:0021510)	2.42832021
83	sulfation (GO:0051923)	2.42128283
84	head development (GO:0060322)	2.41663789
85	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.41517009
86	indole-containing compound metabolic process (GO:0042430)	2.41035293
87	spinal cord motor neuron differentiation (GO:0021522)	2.41001849
88	sympathetic nervous system development (GO:0048485)	2.40943048
89	regulation of action potential (GO:0098900)	2.40352491
90	regulation of meiosis I (GO:0060631)	2.39429653
91	serotonin metabolic process (GO:0042428)	2.39355009
92	meiotic chromosome segregation (GO:0045132)	2.38068015
93	primary amino compound metabolic process (GO:1901160)	2.37955980
94	synaptic transmission, cholinergic (GO:0007271)	2.37730656
95	smoothened signaling pathway (GO:0007224)	2.37486387
96	male meiosis (GO:0007140)	2.36284237
97	rhodopsin mediated signaling pathway (GO:0016056)	2.36259018
98	microtubule anchoring (GO:0034453)	2.35986869
99	C4-dicarboxylate transport (GO:0015740)	2.35576308
100	axoneme assembly (GO:0035082)	2.35473551

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.89178544
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.31345699
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.25276450
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.18025362
5	VDR_22108803_ChIP-Seq_LS180_Human	2.87135592
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.80275991
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.74285910
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.49144397
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.40629521
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.32720224
11	P300_19829295_ChIP-Seq_ESCs_Human	2.24781331
12	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.13404276
13	FUS_26573619_Chip-Seq_HEK293_Human	2.13311495
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.12537281
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.11085139
16	EWS_26573619_Chip-Seq_HEK293_Human	2.09526220
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.09026676
18	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.89750661
19	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.84713149
20	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.81229373
21	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.78939485
22	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.75697469
23	TAF15_26573619_Chip-Seq_HEK293_Human	1.72933379
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.71909635
25	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.69072773
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.68183072
27	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.67609240
28	SMAD4_21799915_ChIP-Seq_A2780_Human	1.65821881
29	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.64966141
30	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.64232141
31	STAT3_23295773_ChIP-Seq_U87_Human	1.63671014
32	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.62418370
33	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.61826259
34	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.61733720
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.57651993
36	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.56055617
37	IRF1_19129219_ChIP-ChIP_H3396_Human	1.54132772
38	TCF4_23295773_ChIP-Seq_U87_Human	1.53947052
39	REST_21632747_ChIP-Seq_MESCs_Mouse	1.53123858
40	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.52504976
41	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.52504976
42	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.52479330
43	BCAT_22108803_ChIP-Seq_LS180_Human	1.52058086
44	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.51207612
45	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.51123530
46	CBP_20019798_ChIP-Seq_JUKART_Human	1.51123530
47	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.50472866
48	AR_25329375_ChIP-Seq_VCAP_Human	1.50410865
49	AR_21572438_ChIP-Seq_LNCaP_Human	1.50004292
50	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.48428427
51	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.40560980
52	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.38257729
53	RNF2_27304074_Chip-Seq_NSC_Mouse	1.36696640
54	TP53_22573176_ChIP-Seq_HFKS_Human	1.34258684
55	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.32999270
56	MYC_18940864_ChIP-ChIP_HL60_Human	1.30547308
57	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.30535824
58	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.30111752
59	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.29657784
60	RUNX2_22187159_ChIP-Seq_PCA_Human	1.28293517
61	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.28086808
62	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.27841340
63	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.25732637
64	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.25571529
65	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.23460017
66	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.21087370
67	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.20826605
68	* KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.20260477
69	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.20171240
70	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.19455446
71	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.17213335
72	TCF4_22108803_ChIP-Seq_LS180_Human	1.17015149
73	SOX2_19829295_ChIP-Seq_ESCs_Human	1.16400287
74	NANOG_19829295_ChIP-Seq_ESCs_Human	1.16400287
75	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.15818779
76	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.15739274
77	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.13871797
78	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.09640620
79	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.09235481
80	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.08192534
81	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.07807363
82	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.07550461
83	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.07221608
84	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.06675357
85	* FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.06157322
86	* FOXA1_25329375_ChIP-Seq_VCAP_Human	1.06157322
87	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.06072133
88	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04943819
89	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.04833914
90	P53_22387025_ChIP-Seq_ESCs_Mouse	1.04102027
91	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.03161314
92	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.02063310
93	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.99693898
94	TP53_16413492_ChIP-PET_HCT116_Human	0.99071061
95	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.98526496
96	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.98449611
97	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.98004851
98	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.96658588
99	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.96477919
100	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.96433929

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.62659069
2	MP0003787_abnormal_imprinting	2.94555676
3	MP0003195_calcinosis	2.92781781
4	MP0000569_abnormal_digit_pigmentation	2.49352425
5	MP0003880_abnormal_central_pattern	2.47999266
6	MP0002102_abnormal_ear_morphology	2.43908618
7	MP0006292_abnormal_olfactory_placode	2.32310080
8	MP0005551_abnormal_eye_electrophysiolog	2.26919968
9	MP0003136_yellow_coat_color	2.18442534
10	MP0006276_abnormal_autonomic_nervous	2.00158252
11	MP0009046_muscle_twitch	1.96987338
12	MP0001968_abnormal_touch/_nociception	1.94815713
13	MP0005645_abnormal_hypothalamus_physiol	1.94231087
14	MP0000778_abnormal_nervous_system	1.92980355
15	MP0003122_maternal_imprinting	1.92613533
16	MP0004885_abnormal_endolymph	1.91370267
17	MP0009745_abnormal_behavioral_response	1.87702579
18	MP0002638_abnormal_pupillary_reflex	1.84473566
19	MP0004133_heterotaxia	1.80473875
20	MP0003890_abnormal_embryonic-extraembry	1.78132737
21	MP0006072_abnormal_retinal_apoptosis	1.73980936
22	MP0002272_abnormal_nervous_system	1.72813795
23	MP0003121_genomic_imprinting	1.72492826
24	MP0000427_abnormal_hair_cycle	1.72241256
25	MP0008872_abnormal_physiological_respon	1.63605114
26	MP0002735_abnormal_chemical_nociception	1.63444822
27	MP0002837_dystrophic_cardiac_calcinosis	1.58573256
28	MP0002736_abnormal_nociception_after	1.57543184
29	MP0000631_abnormal_neuroendocrine_gland	1.54729433
30	MP0001486_abnormal_startle_reflex	1.53539655
31	MP0002254_reproductive_system_inflammat	1.50294187
32	MP0001501_abnormal_sleep_pattern	1.48011243
33	MP0005253_abnormal_eye_physiology	1.46300592
34	MP0002653_abnormal_ependyma_morphology	1.44253788
35	MP0002938_white_spotting	1.44086934
36	MP0001984_abnormal_olfaction	1.44021921
37	MP0002234_abnormal_pharynx_morphology	1.43916980
38	MP0002064_seizures	1.43767763
39	MP0002572_abnormal_emotion/affect_behav	1.41941719
40	MP0001986_abnormal_taste_sensitivity	1.41617487
41	MP0002876_abnormal_thyroid_physiology	1.41399606
42	MP0002928_abnormal_bile_duct	1.40778544
43	MP0003635_abnormal_synaptic_transmissio	1.39152241
44	MP0002557_abnormal_social/conspecific_i	1.38391291
45	MP0008057_abnormal_DNA_replication	1.37785944
46	MP0004043_abnormal_pH_regulation	1.37604500
47	MP0003119_abnormal_digestive_system	1.37135526
48	MP0004924_abnormal_behavior	1.36471391
49	MP0005386_behavior/neurological_phenoty	1.36471391
50	MP0003646_muscle_fatigue	1.34860875
51	MP0002163_abnormal_gland_morphology	1.32157231
52	MP0004142_abnormal_muscle_tone	1.32015454
53	MP0002751_abnormal_autonomic_nervous	1.31305293
54	MP0001529_abnormal_vocalization	1.30698953
55	MP0002909_abnormal_adrenal_gland	1.28899157
56	MP0002063_abnormal_learning/memory/cond	1.27900811
57	MP0003718_maternal_effect	1.26977176
58	MP0004742_abnormal_vestibular_system	1.22185085
59	MP0008875_abnormal_xenobiotic_pharmacok	1.19374719
60	MP0002734_abnormal_mechanical_nocicepti	1.15768550
61	MP0005379_endocrine/exocrine_gland_phen	1.15304939
62	MP0005646_abnormal_pituitary_gland	1.14415560
63	MP0001970_abnormal_pain_threshold	1.12921974
64	MP0000647_abnormal_sebaceous_gland	1.12754079
65	MP0005195_abnormal_posterior_eye	1.11655098
66	MP0002067_abnormal_sensory_capabilities	1.11399061
67	MP0001502_abnormal_circadian_rhythm	1.09514499
68	MP0002184_abnormal_innervation	1.08639367
69	MP0001293_anophthalmia	1.06266412
70	MP0002160_abnormal_reproductive_system	1.06167383
71	MP0000372_irregular_coat_pigmentation	1.05401057
72	MP0005389_reproductive_system_phenotype	1.03581374
73	MP0000955_abnormal_spinal_cord	1.03220424
74	MP0003937_abnormal_limbs/digits/tail_de	1.01874621
75	MP0002733_abnormal_thermal_nociception	1.01404579
76	MP0008789_abnormal_olfactory_epithelium	1.01309610
77	MP0005171_absent_coat_pigmentation	1.00561603
78	MP0005394_taste/olfaction_phenotype	0.98726846
79	MP0005499_abnormal_olfactory_system	0.98726846
80	MP0001485_abnormal_pinna_reflex	0.98404546
81	MP0002752_abnormal_somatic_nervous	0.96378385
82	MP0000383_abnormal_hair_follicle	0.93737403
83	MP0005084_abnormal_gallbladder_morpholo	0.91017843
84	MP0005174_abnormal_tail_pigmentation	0.90034236
85	MP0002882_abnormal_neuron_morphology	0.89910439
86	MP0004145_abnormal_muscle_electrophysio	0.86911581
87	MP0003698_abnormal_male_reproductive	0.86292852
88	MP0005423_abnormal_somatic_nervous	0.85664306
89	MP0002210_abnormal_sex_determination	0.83989533
90	MP0009697_abnormal_copulation	0.83880278
91	MP0000538_abnormal_urinary_bladder	0.80211695
92	MP0003283_abnormal_digestive_organ	0.80027974
93	MP0000026_abnormal_inner_ear	0.79158380
94	MP0008995_early_reproductive_senescence	0.78077464
95	MP0001929_abnormal_gametogenesis	0.78029976
96	MP0008058_abnormal_DNA_repair	0.77980565
97	MP0002152_abnormal_brain_morphology	0.77846867
98	MP0005391_vision/eye_phenotype	0.76749725
99	MP0002822_catalepsy	0.75753577
100	MP0003861_abnormal_nervous_system	0.75318032

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.53905333
2	Hyperventilation (HP:0002883)	4.38276174
3	True hermaphroditism (HP:0010459)	3.91901858
4	Pancreatic fibrosis (HP:0100732)	3.87391687
5	Molar tooth sign on MRI (HP:0002419)	3.83180003
6	Abnormality of midbrain morphology (HP:0002418)	3.83180003
7	Type II lissencephaly (HP:0007260)	3.53395962
8	Congenital stationary night blindness (HP:0007642)	3.52142692
9	Nephronophthisis (HP:0000090)	3.48659516
10	Medial flaring of the eyebrow (HP:0010747)	3.21585530
11	Abnormality of the renal medulla (HP:0100957)	3.07182057
12	Abnormality of the renal cortex (HP:0011035)	3.04300851
13	Chronic hepatic failure (HP:0100626)	2.96816971
14	Cerebellar dysplasia (HP:0007033)	2.90341803
15	Gait imbalance (HP:0002141)	2.85612969
16	Focal motor seizures (HP:0011153)	2.84728614
17	Lissencephaly (HP:0001339)	2.81073070
18	Abnormality of the labia minora (HP:0012880)	2.79259969
19	Congenital primary aphakia (HP:0007707)	2.66149350
20	Focal seizures (HP:0007359)	2.61735414
21	Cystic liver disease (HP:0006706)	2.58350878
22	Anencephaly (HP:0002323)	2.57421149
23	Hepatoblastoma (HP:0002884)	2.53865960
24	Tubular atrophy (HP:0000092)	2.53221885
25	Progressive inability to walk (HP:0002505)	2.50546140
26	Broad-based gait (HP:0002136)	2.49554450
27	Nephrogenic diabetes insipidus (HP:0009806)	2.48997916
28	Inability to walk (HP:0002540)	2.47708797
29	Pendular nystagmus (HP:0012043)	2.45051634
30	Vaginal atresia (HP:0000148)	2.43968241
31	Genital tract atresia (HP:0001827)	2.42967288
32	Abolished electroretinogram (ERG) (HP:0000550)	2.42696095
33	Protruding tongue (HP:0010808)	2.41315110
34	Attenuation of retinal blood vessels (HP:0007843)	2.40446542
35	Patellar aplasia (HP:0006443)	2.39578543
36	Increased corneal curvature (HP:0100692)	2.39054273
37	Keratoconus (HP:0000563)	2.39054273
38	Concave nail (HP:0001598)	2.35833105
39	Drooling (HP:0002307)	2.33667216
40	Neoplasm of the adrenal cortex (HP:0100641)	2.33029953
41	Gaze-evoked nystagmus (HP:0000640)	2.31041794
42	Hypothermia (HP:0002045)	2.30611868
43	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.28551897
44	Febrile seizures (HP:0002373)	2.28346766
45	Sclerocornea (HP:0000647)	2.27469657
46	Hemiparesis (HP:0001269)	2.26878012
47	Abnormality of the pons (HP:0007361)	2.25838779
48	Abnormal biliary tract physiology (HP:0012439)	2.22778196
49	Bile duct proliferation (HP:0001408)	2.22778196
50	Hypoplasia of the pons (HP:0012110)	2.22190390
51	Colon cancer (HP:0003003)	2.18168698
52	Aplasia/Hypoplasia of the patella (HP:0006498)	2.18157130
53	Atonic seizures (HP:0010819)	2.16114742
54	Abnormal rod and cone electroretinograms (HP:0008323)	2.15909074
55	Abnormal drinking behavior (HP:0030082)	2.11771749
56	Polydipsia (HP:0001959)	2.11771749
57	Excessive salivation (HP:0003781)	2.07975979
58	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.07780726
59	Intestinal atresia (HP:0011100)	2.07573494
60	Chorioretinal atrophy (HP:0000533)	2.06130513
61	Poor coordination (HP:0002370)	2.05345598
62	Dandy-Walker malformation (HP:0001305)	2.03216950
63	Pachygyria (HP:0001302)	2.01282017
64	Absent speech (HP:0001344)	1.99549761
65	Optic nerve hypoplasia (HP:0000609)	1.99224965
66	Dialeptic seizures (HP:0011146)	1.98533053
67	Postaxial hand polydactyly (HP:0001162)	1.95028589
68	Fair hair (HP:0002286)	1.94338187
69	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.93968020
70	Stomach cancer (HP:0012126)	1.93626481
71	Congenital hepatic fibrosis (HP:0002612)	1.93361763
72	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.92840305
73	Volvulus (HP:0002580)	1.91537413
74	Hypomagnesemia (HP:0002917)	1.91320363
75	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.91106277
76	Postaxial foot polydactyly (HP:0001830)	1.90862196
77	Astigmatism (HP:0000483)	1.90741253
78	Large for gestational age (HP:0001520)	1.89204805
79	Oligodactyly (hands) (HP:0001180)	1.87577583
80	Widely spaced teeth (HP:0000687)	1.85975259
81	Renal cortical cysts (HP:0000803)	1.85875342
82	Progressive cerebellar ataxia (HP:0002073)	1.83968125
83	Furrowed tongue (HP:0000221)	1.83847067
84	Abnormality of the ileum (HP:0001549)	1.83791134
85	Bony spicule pigmentary retinopathy (HP:0007737)	1.83301391
86	Meckel diverticulum (HP:0002245)	1.82836591
87	Male pseudohermaphroditism (HP:0000037)	1.82670433
88	Polyuria (HP:0000103)	1.82269246
89	Hyperinsulinemic hypoglycemia (HP:0000825)	1.82138509
90	Ectopic kidney (HP:0000086)	1.75800505
91	Decreased central vision (HP:0007663)	1.75157582
92	Ketosis (HP:0001946)	1.74798849
93	Birth length less than 3rd percentile (HP:0003561)	1.67405030
94	Epileptic encephalopathy (HP:0200134)	1.66335646
95	Short foot (HP:0001773)	1.65852263
96	Ketoacidosis (HP:0001993)	1.65668265
97	Absent thumb (HP:0009777)	1.65176289
98	Bilateral microphthalmos (HP:0007633)	1.63770710
99	Polyphagia (HP:0002591)	1.63417341
100	Preaxial hand polydactyly (HP:0001177)	1.63382094

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.62017576
2	CASK	3.78207633
3	NUAK1	2.82931536
4	BMPR1B	2.53642309
5	ADRBK2	2.52047825
6	ACVR1B	2.51505554
7	MARK1	2.49469784
8	MAP4K2	2.46325159
9	WNK3	2.38249240
10	PINK1	2.07707885
11	MAP3K4	2.05503207
12	GRK1	1.87928895
13	INSRR	1.86900510
14	WNK4	1.86403548
15	TNIK	1.84998188
16	ZAK	1.83783166
17	MAPK13	1.81527874
18	TRIM28	1.69770982
19	PNCK	1.65499465
20	DAPK2	1.56657807
21	TLK1	1.53985754
22	FGFR2	1.41920597
23	MAP3K9	1.41567183
24	MKNK2	1.40746308
25	PAK3	1.40223943
26	CAMK1D	1.33938359
27	CAMKK2	1.30204420
28	LATS1	1.29956299
29	TAF1	1.28942068
30	CAMK1G	1.26535402
31	NTRK2	1.24548443
32	OXSR1	1.24285540
33	DYRK2	1.21719582
34	MAP2K7	1.20810316
35	NTRK3	1.17260493
36	PLK2	1.15777231
37	NLK	1.06353164
38	SIK2	1.06047580
39	CSNK1G1	1.04271615
40	STK39	1.03527035
41	BCR	1.00361466
42	EPHA4	0.98197480
43	CSNK1G2	0.94171811
44	MAPK15	0.92482249
45	STK38L	0.89429661
46	VRK1	0.88954146
47	ADRBK1	0.85547898
48	EPHA3	0.84813431
49	TGFBR1	0.84372987
50	BRSK2	0.84288464
51	PRKCG	0.82448519
52	PKN1	0.80754710
53	PRKCE	0.78062979
54	TAOK3	0.76312152
55	CSNK1G3	0.74824062
56	CAMK1	0.74595542
57	TIE1	0.74592383
58	STK3	0.74178751
59	PLK3	0.71577212
60	CSNK1A1L	0.69263167
61	AKT3	0.67440984
62	MAP2K6	0.66565196
63	MKNK1	0.66499266
64	ERBB3	0.63349414
65	TXK	0.62715738
66	IRAK1	0.61793222
67	CDK3	0.61774798
68	STK11	0.55811698
69	SGK2	0.53769692
70	CHUK	0.51103926
71	PRKCI	0.49953392
72	DYRK1A	0.48391691
73	PRKAA1	0.48279537
74	CAMK4	0.48044958
75	KSR1	0.47591775
76	CSNK1D	0.47152538
77	TSSK6	0.46949302
78	CAMK2A	0.46620862
79	PIK3CA	0.46424605
80	PLK4	0.46211443
81	NEK2	0.42772902
82	PRKCZ	0.41923031
83	PHKG2	0.41672086
84	PHKG1	0.41672086
85	CSNK1A1	0.41148421
86	CHEK2	0.40209478
87	SGK494	0.38983506
88	SGK223	0.38983506
89	CAMKK1	0.37894276
90	MAPKAPK5	0.35123595
91	PTK2B	0.35079577
92	TYRO3	0.33544956
93	FER	0.33426088
94	MUSK	0.33174802
95	PRKACA	0.32828003
96	PRKG1	0.32468206
97	ATM	0.30681146
98	RPS6KA5	0.29647285
99	MINK1	0.27554029
100	WNK1	0.24867945

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.02441881
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.84449163
3	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.83661136
4	Butanoate metabolism_Homo sapiens_hsa00650	2.77592523
5	Nicotine addiction_Homo sapiens_hsa05033	2.65879451
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.48749141
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.40053647
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.30796136
9	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.28419325
10	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.20855427
11	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.19881122
12	Nitrogen metabolism_Homo sapiens_hsa00910	2.16972697
13	Selenocompound metabolism_Homo sapiens_hsa00450	2.07791328
14	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.07591840
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.97816073
16	Basal transcription factors_Homo sapiens_hsa03022	1.95505955
17	Fanconi anemia pathway_Homo sapiens_hsa03460	1.90376855
18	Protein export_Homo sapiens_hsa03060	1.85981249
19	Ether lipid metabolism_Homo sapiens_hsa00565	1.81633590
20	Caffeine metabolism_Homo sapiens_hsa00232	1.73122623
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.73037961
22	Taste transduction_Homo sapiens_hsa04742	1.60361058
23	Insulin secretion_Homo sapiens_hsa04911	1.55132815
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.47483815
25	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.46519503
26	Propanoate metabolism_Homo sapiens_hsa00640	1.44859281
27	Morphine addiction_Homo sapiens_hsa05032	1.43722664
28	GABAergic synapse_Homo sapiens_hsa04727	1.38362314
29	Olfactory transduction_Homo sapiens_hsa04740	1.28713527
30	Glutamatergic synapse_Homo sapiens_hsa04724	1.28473276
31	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.25552111
32	Oxidative phosphorylation_Homo sapiens_hsa00190	1.24780167
33	RNA polymerase_Homo sapiens_hsa03020	1.21175047
34	Circadian entrainment_Homo sapiens_hsa04713	1.20738645
35	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.18222945
36	ABC transporters_Homo sapiens_hsa02010	1.14017960
37	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.12254225
38	Regulation of autophagy_Homo sapiens_hsa04140	1.11070835
39	RNA degradation_Homo sapiens_hsa03018	1.10290533
40	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.10245374
41	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.04218343
42	Peroxisome_Homo sapiens_hsa04146	1.03979386
43	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.01333406
44	Homologous recombination_Homo sapiens_hsa03440	0.98874179
45	Salivary secretion_Homo sapiens_hsa04970	0.95049319
46	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.94476208
47	Chemical carcinogenesis_Homo sapiens_hsa05204	0.93026435
48	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.92946301
49	Serotonergic synapse_Homo sapiens_hsa04726	0.92436274
50	Cardiac muscle contraction_Homo sapiens_hsa04260	0.85162483
51	Steroid biosynthesis_Homo sapiens_hsa00100	0.85097628
52	Basal cell carcinoma_Homo sapiens_hsa05217	0.84307151
53	Collecting duct acid secretion_Homo sapiens_hsa04966	0.83567062
54	One carbon pool by folate_Homo sapiens_hsa00670	0.82638910
55	Dopaminergic synapse_Homo sapiens_hsa04728	0.82247936
56	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.80069421
57	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.77487765
58	Cocaine addiction_Homo sapiens_hsa05030	0.75815714
59	Calcium signaling pathway_Homo sapiens_hsa04020	0.75415186
60	Lysine degradation_Homo sapiens_hsa00310	0.74225151
61	Retinol metabolism_Homo sapiens_hsa00830	0.72876492
62	Parkinsons disease_Homo sapiens_hsa05012	0.69988031
63	Long-term depression_Homo sapiens_hsa04730	0.69114407
64	Huntingtons disease_Homo sapiens_hsa05016	0.68784761
65	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.68047421
66	beta-Alanine metabolism_Homo sapiens_hsa00410	0.67807461
67	Mineral absorption_Homo sapiens_hsa04978	0.65277001
68	Cholinergic synapse_Homo sapiens_hsa04725	0.64786177
69	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.64484251
70	cAMP signaling pathway_Homo sapiens_hsa04024	0.63853168
71	Axon guidance_Homo sapiens_hsa04360	0.63472482
72	Histidine metabolism_Homo sapiens_hsa00340	0.62945309
73	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.62132735
74	Amphetamine addiction_Homo sapiens_hsa05031	0.59543226
75	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.58533716
76	Circadian rhythm_Homo sapiens_hsa04710	0.57405576
77	Glycerolipid metabolism_Homo sapiens_hsa00561	0.56916453
78	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.56719320
79	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.56565688
80	Alzheimers disease_Homo sapiens_hsa05010	0.55263715
81	Hippo signaling pathway_Homo sapiens_hsa04390	0.54985648
82	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.53638759
83	Fatty acid degradation_Homo sapiens_hsa00071	0.51442937
84	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.46529277
85	Sphingolipid metabolism_Homo sapiens_hsa00600	0.45754776
86	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.44565429
87	Metabolic pathways_Homo sapiens_hsa01100	0.44066864
88	Non-homologous end-joining_Homo sapiens_hsa03450	0.43470241
89	Fat digestion and absorption_Homo sapiens_hsa04975	0.43386058
90	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.41956644
91	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.41909782
92	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.41152936
93	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.37810760
94	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.36658364
95	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.36609619
96	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.36418465
97	Wnt signaling pathway_Homo sapiens_hsa04310	0.34735809
98	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.34695679
99	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.34409055
100	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.31157721

ZNF329

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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