ZNF331

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a zinc finger protein containing a KRAB (Kruppel-associated box) domain found in transcriptional repressors. This gene may be methylated and silenced in cancer cells. This gene is located within a differentially methylated region (DMR) and shows allele-specific expression in placenta. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)6.28638696
2regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)6.28638696
3positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO6.27451172
4regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)6.27451172
5positive regulation of mRNA catabolic process (GO:0061014)5.76284294
6regulation of mRNA catabolic process (GO:0061013)4.76709557
7negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.62250589
8negative regulation of translation, ncRNA-mediated (GO:0040033)4.62250589
9regulation of translation, ncRNA-mediated (GO:0045974)4.62250589
10positive regulation of mRNA 3-end processing (GO:0031442)4.52504723
11RNA destabilization (GO:0050779)4.12225160
12regulation of mRNA 3-end processing (GO:0031440)4.04053222
13positive regulation of mRNA metabolic process (GO:1903313)3.88743672
14positive regulation of mRNA processing (GO:0050685)3.80822578
15cAMP catabolic process (GO:0006198)3.52585254
16response to pheromone (GO:0019236)3.48772700
17axoneme assembly (GO:0035082)3.32893823
18negative regulation of JUN kinase activity (GO:0043508)3.23882907
19regulation of meiosis I (GO:0060631)3.23538739
20cyclic nucleotide catabolic process (GO:0009214)3.17471275
21establishment of protein localization to Golgi (GO:0072600)3.16602750
22piRNA metabolic process (GO:0034587)3.07141338
23kidney morphogenesis (GO:0060993)3.04890205
24protein localization to Golgi apparatus (GO:0034067)2.99268853
25fucose catabolic process (GO:0019317)2.98499111
26L-fucose metabolic process (GO:0042354)2.98499111
27L-fucose catabolic process (GO:0042355)2.98499111
28negative regulation of cytosolic calcium ion concentration (GO:0051481)2.97781401
29indolalkylamine metabolic process (GO:0006586)2.92106800
30synapsis (GO:0007129)2.89580478
31protein targeting to Golgi (GO:0000042)2.89318193
32signal peptide processing (GO:0006465)2.89234442
33epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.88862886
34intestinal epithelial cell development (GO:0060576)2.88752542
35protein K11-linked deubiquitination (GO:0035871)2.88387253
36photoreceptor cell maintenance (GO:0045494)2.83332652
37regulation of gene silencing by RNA (GO:0060966)2.81111902
38regulation of posttranscriptional gene silencing (GO:0060147)2.81111902
39regulation of gene silencing by miRNA (GO:0060964)2.81111902
40glycerophospholipid catabolic process (GO:0046475)2.79794625
41respiratory chain complex IV assembly (GO:0008535)2.78011239
42neural tube formation (GO:0001841)2.77371602
43detection of light stimulus involved in visual perception (GO:0050908)2.76483131
44detection of light stimulus involved in sensory perception (GO:0050962)2.76483131
45estrogen biosynthetic process (GO:0006703)2.68768817
46negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.65340811
47mitotic cell cycle arrest (GO:0071850)2.65205779
48auditory receptor cell stereocilium organization (GO:0060088)2.65057196
49regulation of glucokinase activity (GO:0033131)2.64868937
50regulation of hexokinase activity (GO:1903299)2.64868937
51cellular ketone body metabolic process (GO:0046950)2.61587860
52behavioral response to nicotine (GO:0035095)2.57492879
53histone H2A acetylation (GO:0043968)2.57263524
54reciprocal meiotic recombination (GO:0007131)2.57181653
55reciprocal DNA recombination (GO:0035825)2.57181653
56photoreceptor cell development (GO:0042461)2.57168198
57retinal cone cell development (GO:0046549)2.56080172
58cellular response to gonadotropin stimulus (GO:0071371)2.55865729
59RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.54556272
60tryptophan catabolic process (GO:0006569)2.53556895
61indole-containing compound catabolic process (GO:0042436)2.53556895
62indolalkylamine catabolic process (GO:0046218)2.53556895
63detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.52008757
64cytochrome complex assembly (GO:0017004)2.51745848
65eye photoreceptor cell development (GO:0042462)2.51243474
66keratinocyte development (GO:0003334)2.51021498
67centriole replication (GO:0007099)2.50602030
68positive regulation of histone H3-K4 methylation (GO:0051571)2.50242236
69retrograde transport, vesicle recycling within Golgi (GO:0000301)2.48913990
70indole-containing compound metabolic process (GO:0042430)2.47769882
71male meiosis I (GO:0007141)2.47701127
72reflex (GO:0060004)2.45658328
73toxin metabolic process (GO:0009404)2.45334595
74alpha-beta T cell differentiation (GO:0046632)2.42765994
75histone H3-K4 trimethylation (GO:0080182)2.42544443
76water-soluble vitamin biosynthetic process (GO:0042364)2.41239034
77negative regulation of DNA-dependent DNA replication (GO:2000104)2.40469780
78negative regulation of cAMP-mediated signaling (GO:0043951)2.40349749
79regulation of telomere maintenance (GO:0032204)2.40071637
80regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.39246329
81regulation of mitotic spindle checkpoint (GO:1903504)2.39246329
82regulation of male gonad development (GO:2000018)2.39085040
83phosphorelay signal transduction system (GO:0000160)2.38962502
84positive regulation of meiotic cell cycle (GO:0051446)2.38239993
85positive regulation of meiosis (GO:0045836)2.37758632
86tolerance induction (GO:0002507)2.36482088
87regulation of fibroblast apoptotic process (GO:2000269)2.35842301
88insulin secretion (GO:0030073)2.35482640
89protein localization to cilium (GO:0061512)2.34568431
90monoubiquitinated protein deubiquitination (GO:0035520)2.33998747
91somite rostral/caudal axis specification (GO:0032525)2.33930389
92male meiosis (GO:0007140)2.33717434
93tryptophan metabolic process (GO:0006568)2.29665349
94negative T cell selection (GO:0043383)2.29115296
95peptidyl-lysine trimethylation (GO:0018023)2.28815151
96negative regulation of multicellular organism growth (GO:0040015)2.27372729
97serotonin metabolic process (GO:0042428)2.27027982
98recombinational repair (GO:0000725)2.26966744
99nodal signaling pathway (GO:0038092)2.26418568
100primary amino compound metabolic process (GO:1901160)2.26330758

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.44506853
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.23856500
3ZNF274_21170338_ChIP-Seq_K562_Hela3.15001504
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.89468273
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.69546535
6GBX2_23144817_ChIP-Seq_PC3_Human2.60134988
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.54190792
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.53665668
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.46150141
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.39417934
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.35426449
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.29269052
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.28901007
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.18187957
15FUS_26573619_Chip-Seq_HEK293_Human2.16957271
16TAF15_26573619_Chip-Seq_HEK293_Human2.14929462
17P300_19829295_ChIP-Seq_ESCs_Human2.06140893
18EWS_26573619_Chip-Seq_HEK293_Human2.05276713
19IGF1R_20145208_ChIP-Seq_DFB_Human2.01187397
20CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93515526
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.90641588
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.86499833
23ER_23166858_ChIP-Seq_MCF-7_Human1.79508012
24BCAT_22108803_ChIP-Seq_LS180_Human1.77813880
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.77206204
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73119567
27PIAS1_25552417_ChIP-Seq_VCAP_Human1.70587377
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.62878355
29PCGF2_27294783_Chip-Seq_NPCs_Mouse1.59569039
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55278178
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53781122
32EZH2_27294783_Chip-Seq_NPCs_Mouse1.53756463
33SMAD4_21799915_ChIP-Seq_A2780_Human1.52904920
34MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51820527
35STAT3_23295773_ChIP-Seq_U87_Human1.51404609
36AR_25329375_ChIP-Seq_VCAP_Human1.50527133
37* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46490350
38TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44350341
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44350341
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.43785316
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43691967
42EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.43329506
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42383594
44* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40717900
45NFE2_27457419_Chip-Seq_LIVER_Mouse1.38444265
46NANOG_19829295_ChIP-Seq_ESCs_Human1.36646645
47SOX2_19829295_ChIP-Seq_ESCs_Human1.36646645
48* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36506525
49DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.36139013
50TCF4_22108803_ChIP-Seq_LS180_Human1.35884380
51* CBP_20019798_ChIP-Seq_JUKART_Human1.35724002
52* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35724002
53TCF4_23295773_ChIP-Seq_U87_Human1.33816815
54CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.33762666
55OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30360314
56FLI1_21867929_ChIP-Seq_TH2_Mouse1.29975237
57NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29908118
58VDR_23849224_ChIP-Seq_CD4+_Human1.29745262
59RNF2_27304074_Chip-Seq_NSC_Mouse1.28010452
60TP53_22573176_ChIP-Seq_HFKS_Human1.27893942
61RUNX2_22187159_ChIP-Seq_PCA_Human1.25050633
62ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.24859567
63NANOG_18555785_Chip-Seq_ESCs_Mouse1.24097798
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24002614
65KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.23627365
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23221720
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22468341
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21733433
69AR_21572438_ChIP-Seq_LNCaP_Human1.19770648
70IRF1_19129219_ChIP-ChIP_H3396_Human1.18391990
71EZH2_22144423_ChIP-Seq_EOC_Human1.15062224
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14761359
73CRX_20693478_ChIP-Seq_RETINA_Mouse1.14578305
74GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14480243
75EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14313808
76CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12435286
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.10508319
78* SMAD4_21741376_ChIP-Seq_EPCs_Human1.08734992
79STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07497165
80TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06808825
81MYC_18940864_ChIP-ChIP_HL60_Human1.06187397
82ELK1_19687146_ChIP-ChIP_HELA_Human1.05773308
83FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05316195
84P53_22387025_ChIP-Seq_ESCs_Mouse1.04638309
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04637443
86FOXA1_25329375_ChIP-Seq_VCAP_Human1.03679108
87FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03679108
88E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.03313533
89EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02819211
90E2F1_18555785_Chip-Seq_ESCs_Mouse1.01853252
91FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01434735
92OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98489610
93GATA3_26560356_Chip-Seq_TH2_Human0.98416829
94CDX2_22108803_ChIP-Seq_LS180_Human0.98181622
95PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98153963
96TP63_19390658_ChIP-ChIP_HaCaT_Human0.98056784
97TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97947321
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97924906
99STAT3_18555785_Chip-Seq_ESCs_Mouse0.97717385
100ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97673921

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.09844104
2MP0003787_abnormal_imprinting3.50969202
3MP0003195_calcinosis2.75648137
4MP0008057_abnormal_DNA_replication2.61738391
5MP0001501_abnormal_sleep_pattern2.52377896
6MP0008995_early_reproductive_senescence2.49783771
7MP0005379_endocrine/exocrine_gland_phen2.32538831
8MP0002638_abnormal_pupillary_reflex2.19117417
9MP0005645_abnormal_hypothalamus_physiol2.18014503
10MP0005551_abnormal_eye_electrophysiolog2.09174315
11MP0003880_abnormal_central_pattern2.09116217
12MP0005646_abnormal_pituitary_gland2.07483881
13MP0002837_dystrophic_cardiac_calcinosis2.06904981
14MP0002163_abnormal_gland_morphology2.05142345
15MP0002876_abnormal_thyroid_physiology2.03228543
16MP0005377_hearing/vestibular/ear_phenot1.84516995
17MP0003878_abnormal_ear_physiology1.84516995
18MP0006072_abnormal_retinal_apoptosis1.83009177
19MP0009046_muscle_twitch1.80864660
20MP0001502_abnormal_circadian_rhythm1.70868114
21MP0009745_abnormal_behavioral_response1.69581955
22MP0008058_abnormal_DNA_repair1.68644887
23MP0002009_preneoplasia1.68534994
24MP0000427_abnormal_hair_cycle1.67243425
25MP0005253_abnormal_eye_physiology1.64964022
26MP0003122_maternal_imprinting1.63418901
27MP0008872_abnormal_physiological_respon1.60443058
28MP0002254_reproductive_system_inflammat1.57852776
29MP0001485_abnormal_pinna_reflex1.51027597
30MP0001486_abnormal_startle_reflex1.47976530
31MP0000569_abnormal_digit_pigmentation1.47658159
32MP0000631_abnormal_neuroendocrine_gland1.47325933
33MP0006292_abnormal_olfactory_placode1.44612106
34MP0001968_abnormal_touch/_nociception1.43748471
35MP0002272_abnormal_nervous_system1.42224897
36MP0001984_abnormal_olfaction1.42160265
37MP0002693_abnormal_pancreas_physiology1.41917090
38MP0002557_abnormal_social/conspecific_i1.30922410
39MP0003011_delayed_dark_adaptation1.28182912
40MP0002909_abnormal_adrenal_gland1.23245305
41MP0002102_abnormal_ear_morphology1.21979741
42MP0008961_abnormal_basal_metabolism1.21035584
43MP0004742_abnormal_vestibular_system1.20136243
44MP0003121_genomic_imprinting1.19628156
45MP0001929_abnormal_gametogenesis1.19592992
46MP0003786_premature_aging1.18960313
47MP0001919_abnormal_reproductive_system1.17905398
48MP0000383_abnormal_hair_follicle1.16956519
49MP0002064_seizures1.16894131
50MP0006276_abnormal_autonomic_nervous1.16736683
51MP0002572_abnormal_emotion/affect_behav1.16426491
52MP0005423_abnormal_somatic_nervous1.14987761
53MP0002210_abnormal_sex_determination1.14449472
54MP0001764_abnormal_homeostasis1.10058203
55MP0004043_abnormal_pH_regulation1.08350848
56MP0001986_abnormal_taste_sensitivity1.08051603
57MP0003698_abnormal_male_reproductive1.07692364
58MP0010386_abnormal_urinary_bladder1.06940982
59MP0004142_abnormal_muscle_tone1.05409140
60MP0003283_abnormal_digestive_organ1.05325267
61MP0001145_abnormal_male_reproductive1.03404307
62MP0000653_abnormal_sex_gland1.03255085
63MP0001944_abnormal_pancreas_morphology1.00862115
64MP0005389_reproductive_system_phenotype0.99275997
65MP0000639_abnormal_adrenal_gland0.98939207
66MP0003890_abnormal_embryonic-extraembry0.95299794
67MP0000647_abnormal_sebaceous_gland0.95118328
68MP0002277_abnormal_respiratory_mucosa0.94987395
69MP0005410_abnormal_fertilization0.93566623
70MP0003567_abnormal_fetal_cardiomyocyte0.93518778
71MP0002938_white_spotting0.92804288
72MP0008875_abnormal_xenobiotic_pharmacok0.92477484
73MP0004381_abnormal_hair_follicle0.92279532
74MP0002229_neurodegeneration0.91179120
75MP0002067_abnormal_sensory_capabilities0.90734416
76MP0004924_abnormal_behavior0.90595042
77MP0005386_behavior/neurological_phenoty0.90595042
78MP0005448_abnormal_energy_balance0.89935345
79MP0004885_abnormal_endolymph0.89706432
80MP0005310_abnormal_salivary_gland0.88485370
81MP0005167_abnormal_blood-brain_barrier0.88415247
82MP0003718_maternal_effect0.87837792
83MP0005174_abnormal_tail_pigmentation0.84997440
84MP0003646_muscle_fatigue0.81070695
85MP0005671_abnormal_response_to0.79605864
86MP0002928_abnormal_bile_duct0.77996783
87MP0004133_heterotaxia0.77037994
88MP0005332_abnormal_amino_acid0.76243235
89MP0010329_abnormal_lipoprotein_level0.76080753
90MP0003136_yellow_coat_color0.75237641
91MP0003635_abnormal_synaptic_transmissio0.74179696
92MP0004215_abnormal_myocardial_fiber0.73962024
93MP0004019_abnormal_vitamin_homeostasis0.73720471
94MP0002063_abnormal_learning/memory/cond0.72002932
95MP0001970_abnormal_pain_threshold0.71745869
96MP0005075_abnormal_melanosome_morpholog0.71282517
97MP0000516_abnormal_urinary_system0.70996497
98MP0005367_renal/urinary_system_phenotyp0.70996497
99MP0002090_abnormal_vision0.70743573
100MP0002653_abnormal_ependyma_morphology0.70530170

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.51695564
2Congenital stationary night blindness (HP:0007642)3.37535850
3Molar tooth sign on MRI (HP:0002419)3.13156460
4Abnormality of midbrain morphology (HP:0002418)3.13156460
5Pancreatic fibrosis (HP:0100732)3.10788132
6Nephronophthisis (HP:0000090)3.08901351
7Large for gestational age (HP:0001520)3.02953754
8Stomatitis (HP:0010280)2.98457157
9Hyperventilation (HP:0002883)2.83665096
10True hermaphroditism (HP:0010459)2.78614667
11Abnormality of the renal medulla (HP:0100957)2.78100124
12Progressive cerebellar ataxia (HP:0002073)2.76205140
13Fair hair (HP:0002286)2.74303524
14Stomach cancer (HP:0012126)2.71356903
15Attenuation of retinal blood vessels (HP:0007843)2.70990888
16Abnormality of the renal cortex (HP:0011035)2.70523860
17Gaze-evoked nystagmus (HP:0000640)2.68370296
18Intestinal atresia (HP:0011100)2.66328321
19Hypothermia (HP:0002045)2.61529285
20Polydipsia (HP:0001959)2.61345319
21Abnormal drinking behavior (HP:0030082)2.61345319
22Type II lissencephaly (HP:0007260)2.59778506
23Abnormality of the labia minora (HP:0012880)2.57487557
24Medial flaring of the eyebrow (HP:0010747)2.55907871
25Genetic anticipation (HP:0003743)2.52446585
26Chronic hepatic failure (HP:0100626)2.48738274
27Hemiparesis (HP:0001269)2.46075149
28Broad-based gait (HP:0002136)2.37372985
29Abnormality of the pons (HP:0007361)2.35646523
30Oligodactyly (hands) (HP:0001180)2.25580250
31Widely spaced teeth (HP:0000687)2.19073963
32Polyuria (HP:0000103)2.15957238
33Tubular atrophy (HP:0000092)2.14609103
34Febrile seizures (HP:0002373)2.12960874
35Cystic liver disease (HP:0006706)2.10021378
36Protruding tongue (HP:0010808)2.05832613
37Volvulus (HP:0002580)2.00861255
38Methylmalonic acidemia (HP:0002912)1.99866215
39Colon cancer (HP:0003003)1.99588494
40Hypoplasia of the pons (HP:0012110)1.99190189
41Abolished electroretinogram (ERG) (HP:0000550)1.97526484
42Gait imbalance (HP:0002141)1.97470338
43Tachypnea (HP:0002789)1.97084582
44Congenital primary aphakia (HP:0007707)1.96351809
45Cerebellar dysplasia (HP:0007033)1.96267605
46Hypomagnesemia (HP:0002917)1.93203309
47IgG deficiency (HP:0004315)1.93158428
48Neonatal respiratory distress (HP:0002643)1.92529417
49Optic nerve hypoplasia (HP:0000609)1.92250842
50Genital tract atresia (HP:0001827)1.92082379
51Generalized hypopigmentation of hair (HP:0011358)1.91088513
52Male pseudohermaphroditism (HP:0000037)1.90502747
53Aqueductal stenosis (HP:0002410)1.89858875
54Nephrogenic diabetes insipidus (HP:0009806)1.89295694
55Hypokalemic alkalosis (HP:0001949)1.88707303
56Clumsiness (HP:0002312)1.87593160
57Decreased circulating renin level (HP:0003351)1.87178705
58Vaginal atresia (HP:0000148)1.85634027
59Thyroiditis (HP:0100646)1.84494120
60Epileptic encephalopathy (HP:0200134)1.84002254
61Dialeptic seizures (HP:0011146)1.82549568
62Renal cortical cysts (HP:0000803)1.82548635
63Absent speech (HP:0001344)1.81839535
64Inability to walk (HP:0002540)1.80463458
65Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.79478447
66Metabolic alkalosis (HP:0200114)1.79156859
67Metaphyseal dysplasia (HP:0100255)1.78087263
68Hyperinsulinemic hypoglycemia (HP:0000825)1.78012582
69Congenital, generalized hypertrichosis (HP:0004540)1.77732281
70Bony spicule pigmentary retinopathy (HP:0007737)1.76842098
71Progressive inability to walk (HP:0002505)1.76005747
72Ketoacidosis (HP:0001993)1.74726521
73Abnormality of the phalanges of the 2nd finger (HP:0009541)1.73576742
74Methylmalonic aciduria (HP:0012120)1.73112170
75Bile duct proliferation (HP:0001408)1.70355201
76Abnormal biliary tract physiology (HP:0012439)1.70355201
77Abnormality of vitamin B metabolism (HP:0004340)1.67730370
78Abnormal urine output (HP:0012590)1.67343810
79Aplasia/Hypoplasia of the tibia (HP:0005772)1.66926896
80Abnormal rod and cone electroretinograms (HP:0008323)1.65980357
81Abnormality of renal excretion (HP:0011036)1.65790616
82Duplicated collecting system (HP:0000081)1.65250589
83Disproportionate short-trunk short stature (HP:0003521)1.63488877
84Cupped ear (HP:0000378)1.62051668
85Prostate neoplasm (HP:0100787)1.61754285
86Abnormality of dental color (HP:0011073)1.61664173
87Ketosis (HP:0001946)1.60861469
88Increased circulating renin level (HP:0000848)1.60649685
89Lissencephaly (HP:0001339)1.60410432
90Hypoglycemic seizures (HP:0002173)1.60019590
91Hypoplastic iliac wings (HP:0002866)1.59215660
92Dandy-Walker malformation (HP:0001305)1.57803866
93Abnormal sex determination (HP:0012244)1.56943036
94Sex reversal (HP:0012245)1.56943036
95Abnormality of the renal collecting system (HP:0004742)1.54857586
96Sloping forehead (HP:0000340)1.53087891
97Congenital hepatic fibrosis (HP:0002612)1.51981759
98Postaxial foot polydactyly (HP:0001830)1.51755036
99Atonic seizures (HP:0010819)1.51356521
100Pancreatic islet-cell hyperplasia (HP:0004510)1.50944916

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.76284233
2MST43.72235370
3WNK32.55434794
4ACVR1B2.52434547
5BMPR1B2.28677160
6STK38L2.23444552
7NLK1.99697038
8MKNK21.95661883
9MAP4K21.94368764
10AKT31.93053582
11FGFR21.88928917
12NUAK11.83683999
13TRIM281.82056420
14PASK1.72161767
15ADRBK21.71369067
16TNIK1.70713501
17BRSK21.63167304
18GRK11.61686487
19PNCK1.60525958
20TXK1.56928449
21MAP3K41.53557969
22CASK1.48046064
23TSSK61.47171793
24TAOK31.45730691
25ERBB31.40208222
26PAK31.38039166
27BRD41.37530160
28OXSR11.37140469
29ZAK1.36163717
30DAPK21.30787167
31TEC1.30015828
32TRPM71.26195417
33WEE11.25996643
34ITK1.13608438
35PDK21.13227474
36INSRR1.13005442
37MAPK151.11544277
38MAPK131.09244255
39PLK41.02570395
40PINK11.01983620
41BCR1.01156896
42IKBKB0.97500059
43LATS10.95434491
44NTRK30.94156241
45SGK20.93555894
46EIF2AK30.93377930
47EPHA40.93141111
48UHMK10.91038697
49WNK40.89375290
50MKNK10.88882043
51NME10.85691808
52VRK10.84377452
53PRKCG0.83955698
54IRAK10.83774534
55CAMK1G0.82115353
56TIE10.80956290
57CAMKK20.80108101
58CAMK1D0.79580022
59STK390.78321169
60CHUK0.72420216
61PIK3CA0.71103769
62STK30.69070072
63STK110.66637756
64CDK30.61642837
65MAP2K60.60449410
66PRKCE0.60329839
67SGK4940.59989230
68SGK2230.59989230
69EPHA30.59944120
70TGFBR10.59045792
71DYRK20.58374104
72PLK20.57949695
73NEK60.56568537
74ADRBK10.55256126
75TLK10.54102735
76DYRK1A0.53818136
77PLK30.53657236
78STK100.51276780
79RPS6KA50.50978215
80NTRK20.50753122
81STK380.49292619
82PRKAA10.49191857
83TNK20.47795402
84CAMK10.47672428
85CAMK2D0.44730055
86IKBKE0.44231495
87PRKCQ0.43962329
88HIPK20.43009477
89CSNK1G10.41882848
90MAPK10.39317128
91SGK10.39062663
92PIK3CG0.39003100
93TYRO30.37129504
94MARK30.36779320
95MAP2K20.36449491
96CAMK2A0.36163572
97CSNK1A10.36090601
98CSNK1D0.35381615
99CAMK40.33636860
100PRKACA0.33348537

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049502.90612261
2Protein export_Homo sapiens_hsa030602.78344208
3Circadian rhythm_Homo sapiens_hsa047102.62886651
4Phototransduction_Homo sapiens_hsa047442.58341553
5RNA degradation_Homo sapiens_hsa030182.30686076
6Selenocompound metabolism_Homo sapiens_hsa004502.28355667
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.21119263
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.08411617
9Butanoate metabolism_Homo sapiens_hsa006502.08134607
10Nicotine addiction_Homo sapiens_hsa050331.85741242
11Nitrogen metabolism_Homo sapiens_hsa009101.79066216
12Fanconi anemia pathway_Homo sapiens_hsa034601.75410863
13Homologous recombination_Homo sapiens_hsa034401.74647858
14Linoleic acid metabolism_Homo sapiens_hsa005911.73292617
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.72624916
16Tryptophan metabolism_Homo sapiens_hsa003801.70890107
17Basal transcription factors_Homo sapiens_hsa030221.70485780
18Insulin secretion_Homo sapiens_hsa049111.67043908
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.66949375
20RNA polymerase_Homo sapiens_hsa030201.65130025
21Ether lipid metabolism_Homo sapiens_hsa005651.51525209
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.50492556
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.48262883
24Regulation of autophagy_Homo sapiens_hsa041401.47803940
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.43556650
26Type I diabetes mellitus_Homo sapiens_hsa049401.41798357
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.40361792
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38923311
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36000744
30Propanoate metabolism_Homo sapiens_hsa006401.35239482
31Morphine addiction_Homo sapiens_hsa050321.28958946
32Oxidative phosphorylation_Homo sapiens_hsa001901.27776932
33Primary immunodeficiency_Homo sapiens_hsa053401.22626663
34Circadian entrainment_Homo sapiens_hsa047131.22461020
35Ovarian steroidogenesis_Homo sapiens_hsa049131.16104226
36Amphetamine addiction_Homo sapiens_hsa050311.14360321
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.12015579
38Non-homologous end-joining_Homo sapiens_hsa034501.08842966
39Dorso-ventral axis formation_Homo sapiens_hsa043201.07881537
40Collecting duct acid secretion_Homo sapiens_hsa049661.07661526
41ABC transporters_Homo sapiens_hsa020101.06433981
42Aldosterone synthesis and secretion_Homo sapiens_hsa049251.04983163
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.01748421
44Vitamin digestion and absorption_Homo sapiens_hsa049771.00839025
45Taste transduction_Homo sapiens_hsa047421.00579693
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96187742
47Serotonergic synapse_Homo sapiens_hsa047260.92074850
48Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.91173783
49Olfactory transduction_Homo sapiens_hsa047400.89894411
50Glutamatergic synapse_Homo sapiens_hsa047240.87953354
51Renin secretion_Homo sapiens_hsa049240.87868381
52Peroxisome_Homo sapiens_hsa041460.86631248
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.85227131
54Lysine degradation_Homo sapiens_hsa003100.82848992
55GABAergic synapse_Homo sapiens_hsa047270.80703533
56beta-Alanine metabolism_Homo sapiens_hsa004100.78748306
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77914600
58Mineral absorption_Homo sapiens_hsa049780.76756020
59T cell receptor signaling pathway_Homo sapiens_hsa046600.76359058
60Salivary secretion_Homo sapiens_hsa049700.70382104
61Dopaminergic synapse_Homo sapiens_hsa047280.68230366
62cAMP signaling pathway_Homo sapiens_hsa040240.66279721
63mRNA surveillance pathway_Homo sapiens_hsa030150.65215009
64RNA transport_Homo sapiens_hsa030130.65147465
65Steroid biosynthesis_Homo sapiens_hsa001000.65141996
66Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.64864619
67Autoimmune thyroid disease_Homo sapiens_hsa053200.63536719
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62547980
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61176584
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.60105301
71Calcium signaling pathway_Homo sapiens_hsa040200.59346839
72Purine metabolism_Homo sapiens_hsa002300.58796210
73Parkinsons disease_Homo sapiens_hsa050120.58183744
74NOD-like receptor signaling pathway_Homo sapiens_hsa046210.58115995
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57720914
76Arachidonic acid metabolism_Homo sapiens_hsa005900.57604379
77Caffeine metabolism_Homo sapiens_hsa002320.57460088
78Cardiac muscle contraction_Homo sapiens_hsa042600.55753059
79Long-term depression_Homo sapiens_hsa047300.54500255
80Cocaine addiction_Homo sapiens_hsa050300.53245542
81Retinol metabolism_Homo sapiens_hsa008300.52569177
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52356369
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51726381
84Spliceosome_Homo sapiens_hsa030400.49551976
85One carbon pool by folate_Homo sapiens_hsa006700.49092530
86Huntingtons disease_Homo sapiens_hsa050160.48598091
87Allograft rejection_Homo sapiens_hsa053300.48325440
88Sphingolipid metabolism_Homo sapiens_hsa006000.48246434
89Rheumatoid arthritis_Homo sapiens_hsa053230.45340546
90MAPK signaling pathway_Homo sapiens_hsa040100.45200103
91Glycerolipid metabolism_Homo sapiens_hsa005610.43289064
92Mismatch repair_Homo sapiens_hsa034300.42680444
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.42429663
94Oocyte meiosis_Homo sapiens_hsa041140.41613038
95TGF-beta signaling pathway_Homo sapiens_hsa043500.41071981
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40775153
97Chemical carcinogenesis_Homo sapiens_hsa052040.40761370
98Nucleotide excision repair_Homo sapiens_hsa034200.39595623
99Graft-versus-host disease_Homo sapiens_hsa053320.38920929
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38575878

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