ZNF334

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the C2H2 zinc finger family. The encoded protein contains a Krueppel-associated box, fourteen C2H2 zinc finger domains, and four C2H2-type/integrase DNA-binding domains. Decreased expression of this gene may be a marker for rheumatoid arthritis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)4.29201453
2regulation of cilium movement (GO:0003352)4.06817841
3response to pheromone (GO:0019236)3.97409759
4intraciliary transport (GO:0042073)3.95292781
5nonmotile primary cilium assembly (GO:0035058)3.73468722
6otic vesicle formation (GO:0030916)3.67543694
7presynaptic membrane assembly (GO:0097105)3.58826241
8nucleobase catabolic process (GO:0046113)3.46458433
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.43379268
10epithelial cilium movement (GO:0003351)3.37888367
11presynaptic membrane organization (GO:0097090)3.30266937
12neuron cell-cell adhesion (GO:0007158)2.98976519
13protein localization to cilium (GO:0061512)2.96673440
14cilium movement (GO:0003341)2.92041839
15protein polyglutamylation (GO:0018095)2.85373844
16cilium morphogenesis (GO:0060271)2.83703647
17auditory behavior (GO:0031223)2.80842644
18cilium organization (GO:0044782)2.78000534
19short-term memory (GO:0007614)2.77733255
20cilium assembly (GO:0042384)2.76800023
21chromatin remodeling at centromere (GO:0031055)2.74498909
22olfactory bulb development (GO:0021772)2.73975128
23DNA double-strand break processing (GO:0000729)2.72207742
24limb bud formation (GO:0060174)2.72165418
25regulation of non-canonical Wnt signaling pathway (GO:2000050)2.71794541
26negative regulation of DNA-dependent DNA replication (GO:2000104)2.70697512
27retinal ganglion cell axon guidance (GO:0031290)2.69890517
28cholesterol biosynthetic process (GO:0006695)2.69261042
29somite development (GO:0061053)2.65346335
30replication fork processing (GO:0031297)2.64947856
31protein neddylation (GO:0045116)2.60768761
32mechanosensory behavior (GO:0007638)2.59956057
33behavioral response to nicotine (GO:0035095)2.58893173
34regulation of microtubule-based movement (GO:0060632)2.56695394
35vocalization behavior (GO:0071625)2.55686637
36photoreceptor cell maintenance (GO:0045494)2.55161592
37sterol biosynthetic process (GO:0016126)2.54625557
38C4-dicarboxylate transport (GO:0015740)2.54474810
39regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.52277465
40peptidyl-cysteine modification (GO:0018198)2.50511821
41CENP-A containing nucleosome assembly (GO:0034080)2.49938537
42resolution of meiotic recombination intermediates (GO:0000712)2.49390053
43centriole replication (GO:0007099)2.49263047
44axonal fasciculation (GO:0007413)2.46432335
45axoneme assembly (GO:0035082)2.46124048
46postsynaptic membrane organization (GO:0001941)2.43706649
47calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.41459371
48G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.41055135
49water-soluble vitamin biosynthetic process (GO:0042364)2.35866570
50establishment of protein localization to mitochondrial membrane (GO:0090151)2.35002332
51transmission of nerve impulse (GO:0019226)2.34361812
52respiratory chain complex IV assembly (GO:0008535)2.34001886
53protein complex biogenesis (GO:0070271)2.33816303
54positive regulation of dendritic spine morphogenesis (GO:0061003)2.33359259
55negative regulation of translation, ncRNA-mediated (GO:0040033)2.32446364
56regulation of translation, ncRNA-mediated (GO:0045974)2.32446364
57negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.32446364
58synapse assembly (GO:0007416)2.32249074
59neurotransmitter-gated ion channel clustering (GO:0072578)2.32030430
60detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.31672720
61branched-chain amino acid catabolic process (GO:0009083)2.31496008
62hindbrain development (GO:0030902)2.31251574
63histone H2A acetylation (GO:0043968)2.29992121
64regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.29434987
65dendritic spine morphogenesis (GO:0060997)2.28668716
66limb development (GO:0060173)2.28341141
67appendage development (GO:0048736)2.28341141
68regulation of telomere maintenance (GO:0032204)2.28290316
69chaperone-mediated protein transport (GO:0072321)2.27929008
70neuron recognition (GO:0008038)2.27670584
71histone exchange (GO:0043486)2.26323464
72DNA integration (GO:0015074)2.24746253
73somite rostral/caudal axis specification (GO:0032525)2.23820005
74protein localization to synapse (GO:0035418)2.23697112
75neuronal action potential propagation (GO:0019227)2.23620683
76neural tube formation (GO:0001841)2.23144071
77positive regulation of mitochondrial fission (GO:0090141)2.20744130
78regulation of development, heterochronic (GO:0040034)2.20211237
79cellular ketone body metabolic process (GO:0046950)2.19689768
80seminiferous tubule development (GO:0072520)2.19593161
81cellular component assembly involved in morphogenesis (GO:0010927)2.19019385
82establishment of melanosome localization (GO:0032401)2.18900572
83regulation of helicase activity (GO:0051095)2.17894488
84mitochondrial respiratory chain complex assembly (GO:0033108)2.17660189
85kidney morphogenesis (GO:0060993)2.17450052
86mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.16592197
87mitochondrial respiratory chain complex I assembly (GO:0032981)2.16592197
88NADH dehydrogenase complex assembly (GO:0010257)2.16592197
89single strand break repair (GO:0000012)2.16339098
90cilium or flagellum-dependent cell motility (GO:0001539)2.15799451
91regulation of collateral sprouting (GO:0048670)2.15233177
92reflex (GO:0060004)2.13262178
93GPI anchor metabolic process (GO:0006505)2.12121387
94epithelial cell differentiation involved in kidney development (GO:0035850)2.12056959
95cullin deneddylation (GO:0010388)2.11072218
96negative regulation of transcription regulatory region DNA binding (GO:2000678)2.11064093
97retinal cone cell development (GO:0046549)2.10488877
98forebrain neuron differentiation (GO:0021879)2.08666164
99maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.08357071
100smoothened signaling pathway (GO:0007224)2.08234478

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.26632437
2ZNF274_21170338_ChIP-Seq_K562_Hela2.99044555
3GBX2_23144817_ChIP-Seq_PC3_Human2.91460308
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.83889872
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.73119097
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.69687146
7IGF1R_20145208_ChIP-Seq_DFB_Human2.68119810
8FUS_26573619_Chip-Seq_HEK293_Human2.50101012
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.40540830
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.38067312
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.37040424
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.36181718
13TAF15_26573619_Chip-Seq_HEK293_Human2.31407748
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.22178702
15VDR_22108803_ChIP-Seq_LS180_Human2.19475865
16P300_19829295_ChIP-Seq_ESCs_Human2.15561434
17EWS_26573619_Chip-Seq_HEK293_Human2.15301491
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.13728825
19* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.07824253
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.98580534
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.97850156
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.94738743
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.94158118
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90544634
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.80957028
26POU5F1_16153702_ChIP-ChIP_HESCs_Human1.75038736
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74281792
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.67249012
29RNF2_27304074_Chip-Seq_NSC_Mouse1.65213825
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63765786
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.59993077
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.59070322
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58964954
34SMAD4_21799915_ChIP-Seq_A2780_Human1.57238813
35MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55924659
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53172294
37IRF1_19129219_ChIP-ChIP_H3396_Human1.48596647
38TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46351365
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46172425
40SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45919015
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43712208
42* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43209946
43EST1_17652178_ChIP-ChIP_JURKAT_Human1.42683388
44* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42049520
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40895742
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40895742
47PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40710420
48CBP_20019798_ChIP-Seq_JUKART_Human1.40520398
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40520398
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.40280654
51ELK1_19687146_ChIP-ChIP_HELA_Human1.39413455
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.38039511
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37631338
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33888555
55REST_21632747_ChIP-Seq_MESCs_Mouse1.33845933
56MYC_18940864_ChIP-ChIP_HL60_Human1.31029636
57ER_23166858_ChIP-Seq_MCF-7_Human1.29827170
58STAT3_23295773_ChIP-Seq_U87_Human1.28431313
59SOX2_16153702_ChIP-ChIP_HESCs_Human1.27648032
60TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24286076
61AR_25329375_ChIP-Seq_VCAP_Human1.24285121
62KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24276431
63NANOG_18555785_Chip-Seq_ESCs_Mouse1.23142466
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21203857
65RUNX2_22187159_ChIP-Seq_PCA_Human1.20947047
66NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20500368
67EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19266062
68TCF4_23295773_ChIP-Seq_U87_Human1.19077691
69BCAT_22108803_ChIP-Seq_LS180_Human1.18495189
70TCF4_22108803_ChIP-Seq_LS180_Human1.16771097
71FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.16474806
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16344579
73KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14074735
74TP63_19390658_ChIP-ChIP_HaCaT_Human1.12167863
75P53_22387025_ChIP-Seq_ESCs_Mouse1.10895571
76NANOG_16153702_ChIP-ChIP_HESCs_Human1.10600657
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.10208809
78TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09851753
79SOX2_19829295_ChIP-Seq_ESCs_Human1.09584292
80NANOG_19829295_ChIP-Seq_ESCs_Human1.09584292
81TP53_22573176_ChIP-Seq_HFKS_Human1.08670308
82CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07247731
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.06890137
84STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.04773024
85TAL1_26923725_Chip-Seq_HPCs_Mouse1.03853729
86EZH2_27304074_Chip-Seq_ESCs_Mouse1.03317377
87EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02319213
88RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00041844
89E2F1_18555785_Chip-Seq_ESCs_Mouse0.99454683
90TBX3_20139965_ChIP-Seq_ESCs_Mouse0.99125799
91TBX3_20139965_ChIP-Seq_MESCs_Mouse0.98732019
92TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.98369204
93TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97030101
94REST_18959480_ChIP-ChIP_MESCs_Mouse0.96812369
95PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95851138
96SOX9_26525672_Chip-Seq_HEART_Mouse0.93860963
97SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93772427
98SMAD4_21741376_ChIP-Seq_EPCs_Human0.91651525
99PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91513556
100SOX2_21211035_ChIP-Seq_LN229_Gbm0.91446945

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.24058027
2MP0003122_maternal_imprinting2.97949202
3MP0003880_abnormal_central_pattern2.90923364
4MP0008877_abnormal_DNA_methylation2.65077173
5MP0003787_abnormal_imprinting2.43434192
6MP0003121_genomic_imprinting2.41375193
7MP0002102_abnormal_ear_morphology2.39624986
8MP0001529_abnormal_vocalization2.30171776
9MP0003890_abnormal_embryonic-extraembry2.14215926
10MP0001984_abnormal_olfaction2.12608301
11MP0008789_abnormal_olfactory_epithelium2.10663078
12MP0005394_taste/olfaction_phenotype2.01994286
13MP0005499_abnormal_olfactory_system2.01994286
14MP0003136_yellow_coat_color1.98590837
15MP0002653_abnormal_ependyma_morphology1.97032293
16MP0000778_abnormal_nervous_system1.96437400
17MP0004133_heterotaxia1.79990271
18MP0006276_abnormal_autonomic_nervous1.78099556
19MP0002822_catalepsy1.77441208
20MP0002938_white_spotting1.75544564
21MP0005551_abnormal_eye_electrophysiolog1.73069402
22MP0003567_abnormal_fetal_cardiomyocyte1.69438049
23MP0001293_anophthalmia1.67736918
24MP0008058_abnormal_DNA_repair1.63716492
25MP0005646_abnormal_pituitary_gland1.61743722
26MP0006072_abnormal_retinal_apoptosis1.60718803
27MP0000631_abnormal_neuroendocrine_gland1.55571862
28MP0001188_hyperpigmentation1.54087401
29MP0004270_analgesia1.47715018
30MP0004859_abnormal_synaptic_plasticity1.47401414
31MP0001486_abnormal_startle_reflex1.44930619
32MP0005084_abnormal_gallbladder_morpholo1.44133755
33MP0002751_abnormal_autonomic_nervous1.41868171
34MP0003937_abnormal_limbs/digits/tail_de1.41856098
35MP0002638_abnormal_pupillary_reflex1.41267834
36MP0003119_abnormal_digestive_system1.41126662
37MP0002233_abnormal_nose_morphology1.37925486
38MP0005253_abnormal_eye_physiology1.36607743
39MP0002736_abnormal_nociception_after1.35536874
40MP0002557_abnormal_social/conspecific_i1.34234094
41MP0000516_abnormal_urinary_system1.33706300
42MP0005367_renal/urinary_system_phenotyp1.33706300
43MP0000049_abnormal_middle_ear1.32479421
44MP0002272_abnormal_nervous_system1.32238461
45MP0003123_paternal_imprinting1.30727106
46MP0009046_muscle_twitch1.27685928
47MP0004885_abnormal_endolymph1.25632149
48MP0003635_abnormal_synaptic_transmissio1.22313913
49MP0003195_calcinosis1.22276671
50MP0001968_abnormal_touch/_nociception1.20473971
51MP0004142_abnormal_muscle_tone1.19734399
52MP0001986_abnormal_taste_sensitivity1.17517817
53MP0001485_abnormal_pinna_reflex1.17285168
54MP0002184_abnormal_innervation1.17038449
55MP0000955_abnormal_spinal_cord1.16689884
56MP0002734_abnormal_mechanical_nocicepti1.16603530
57MP0003938_abnormal_ear_development1.15741345
58MP0005645_abnormal_hypothalamus_physiol1.14834755
59MP0002909_abnormal_adrenal_gland1.14719273
60MP0002572_abnormal_emotion/affect_behav1.12442500
61MP0009745_abnormal_behavioral_response1.11162246
62MP0001299_abnormal_eye_distance/1.09626645
63MP0002752_abnormal_somatic_nervous1.08166257
64MP0003011_delayed_dark_adaptation1.07248081
65MP0005423_abnormal_somatic_nervous1.04649666
66MP0002063_abnormal_learning/memory/cond1.02716270
67MP0003718_maternal_effect0.99774486
68MP0001286_abnormal_eye_development0.98648202
69MP0002254_reproductive_system_inflammat0.98410904
70MP0003861_abnormal_nervous_system0.98129174
71MP0002837_dystrophic_cardiac_calcinosis0.96294680
72MP0000566_synostosis0.95437447
73MP0003755_abnormal_palate_morphology0.95275948
74MP0002882_abnormal_neuron_morphology0.95208666
75MP0002152_abnormal_brain_morphology0.92507588
76MP0002234_abnormal_pharynx_morphology0.92357468
77MP0002697_abnormal_eye_size0.90918170
78MP0010030_abnormal_orbit_morphology0.90191833
79MP0002735_abnormal_chemical_nociception0.89658944
80MP0005391_vision/eye_phenotype0.89438529
81MP0005195_abnormal_posterior_eye0.89063213
82MP0002067_abnormal_sensory_capabilities0.88161583
83MP0002064_seizures0.87941382
84MP0000026_abnormal_inner_ear0.87352410
85MP0001970_abnormal_pain_threshold0.85862389
86MP0002876_abnormal_thyroid_physiology0.82333403
87MP0008995_early_reproductive_senescence0.82113319
88MP0000647_abnormal_sebaceous_gland0.81263414
89MP0001177_atelectasis0.80768121
90MP0004811_abnormal_neuron_physiology0.80174891
91MP0002160_abnormal_reproductive_system0.80129194
92MP0004924_abnormal_behavior0.79277770
93MP0005386_behavior/neurological_phenoty0.79277770
94MP0010094_abnormal_chromosome_stability0.77750936
95MP0005248_abnormal_Harderian_gland0.75311158
96MP0001963_abnormal_hearing_physiology0.74999328
97MP0003283_abnormal_digestive_organ0.74540058
98MP0002733_abnormal_thermal_nociception0.73803034
99MP0008872_abnormal_physiological_respon0.72532245
100MP0003698_abnormal_male_reproductive0.71801920

Predicted human phenotypes

RankGene SetZ-score
1Medial flaring of the eyebrow (HP:0010747)3.83060547
2Gait imbalance (HP:0002141)3.57944570
3Pancreatic fibrosis (HP:0100732)3.52375278
4Congenital primary aphakia (HP:0007707)3.49468276
5True hermaphroditism (HP:0010459)3.46123292
6Pancreatic cysts (HP:0001737)3.45442036
7Abnormality of the labia minora (HP:0012880)3.44062813
8Molar tooth sign on MRI (HP:0002419)3.31275427
9Abnormality of midbrain morphology (HP:0002418)3.31275427
10Nephronophthisis (HP:0000090)3.29472173
11Nephrogenic diabetes insipidus (HP:0009806)3.17015532
12Genital tract atresia (HP:0001827)3.15965565
13Vaginal atresia (HP:0000148)3.09851810
14Intestinal atresia (HP:0011100)3.07408444
15Colon cancer (HP:0003003)2.83721153
16Septo-optic dysplasia (HP:0100842)2.81008019
17Abnormality of the renal medulla (HP:0100957)2.72360821
18Renal cortical cysts (HP:0000803)2.69680763
19Volvulus (HP:0002580)2.69475771
20Hyperglycinemia (HP:0002154)2.65849456
21Poor coordination (HP:0002370)2.54781331
22Hepatoblastoma (HP:0002884)2.43266798
23Optic nerve hypoplasia (HP:0000609)2.35999981
24Abnormality of the renal cortex (HP:0011035)2.35371616
25Cystic liver disease (HP:0006706)2.34592644
26Bifid tongue (HP:0010297)2.33045024
27Oligodactyly (hands) (HP:0001180)2.32365558
28Sclerocornea (HP:0000647)2.25342432
29Aplasia/Hypoplasia of the tongue (HP:0010295)2.24696655
30Postaxial hand polydactyly (HP:0001162)2.24625098
31Broad foot (HP:0001769)2.24538255
32Anencephaly (HP:0002323)2.23102060
33Inability to walk (HP:0002540)2.21708077
34Postaxial foot polydactyly (HP:0001830)2.20741495
35Specific learning disability (HP:0001328)2.20118382
36Tubulointerstitial nephritis (HP:0001970)2.20069010
37Polyphagia (HP:0002591)2.19416547
38Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.15571218
39Methylmalonic acidemia (HP:0002912)2.13399216
40Progressive inability to walk (HP:0002505)2.08725278
41Aplasia/Hypoplasia of the tibia (HP:0005772)2.04747128
42Preaxial hand polydactyly (HP:0001177)2.03631059
43Occipital encephalocele (HP:0002085)2.01681517
44Narrow forehead (HP:0000341)2.01359010
45Chronic hepatic failure (HP:0100626)2.00229793
46Abolished electroretinogram (ERG) (HP:0000550)1.99628775
47Gastrointestinal atresia (HP:0002589)1.97048040
48Aplasia/Hypoplasia of the uvula (HP:0010293)1.95990772
49Growth hormone deficiency (HP:0000824)1.94540116
50Hyperventilation (HP:0002883)1.93896178
51Drooling (HP:0002307)1.93205551
52Abnormality of the ileum (HP:0001549)1.91471003
53Stenosis of the external auditory canal (HP:0000402)1.91380077
54Anophthalmia (HP:0000528)1.90345971
55Short tibia (HP:0005736)1.88830677
56Meckel diverticulum (HP:0002245)1.88683608
57Congenital hepatic fibrosis (HP:0002612)1.87739966
58Abnormal ciliary motility (HP:0012262)1.87134810
59Abnormality of serine family amino acid metabolism (HP:0010894)1.84556366
60Abnormality of glycine metabolism (HP:0010895)1.84556366
61Renal hypoplasia (HP:0000089)1.84052067
62Lissencephaly (HP:0001339)1.83647620
63Male pseudohermaphroditism (HP:0000037)1.80573574
64Hypoplastic pelvis (HP:0008839)1.79177392
65Focal motor seizures (HP:0011153)1.79092680
66Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.78906433
67Aqueductal stenosis (HP:0002410)1.78858950
68Astigmatism (HP:0000483)1.78821183
69Aplasia/Hypoplasia of the spleen (HP:0010451)1.78150777
70Acute necrotizing encephalopathy (HP:0006965)1.77657180
71Broad-based gait (HP:0002136)1.77520495
72Decreased testicular size (HP:0008734)1.76925052
73Acute encephalopathy (HP:0006846)1.75314324
74Aplasia/Hypoplasia of the lens (HP:0008063)1.75038845
75Supernumerary spleens (HP:0009799)1.74819067
76Abnormal respiratory motile cilium morphology (HP:0005938)1.74022459
77Abnormal respiratory epithelium morphology (HP:0012253)1.74022459
78Progressive cerebellar ataxia (HP:0002073)1.73098139
79Cerebellar dysplasia (HP:0007033)1.72320490
80Absent/shortened dynein arms (HP:0200106)1.72201417
81Dynein arm defect of respiratory motile cilia (HP:0012255)1.72201417
82Hyperinsulinemic hypoglycemia (HP:0000825)1.71836130
83Thyroid-stimulating hormone excess (HP:0002925)1.71816231
84Aganglionic megacolon (HP:0002251)1.70616361
85Micropenis (HP:0000054)1.70387857
86Dandy-Walker malformation (HP:0001305)1.68839906
87Labial hypoplasia (HP:0000066)1.67263840
88Hyperglycinuria (HP:0003108)1.67123867
89Gonadotropin excess (HP:0000837)1.66871029
90Excessive salivation (HP:0003781)1.66199329
91Abnormal respiratory motile cilium physiology (HP:0012261)1.65804350
92Asplenia (HP:0001746)1.65577820
93Multicystic kidney dysplasia (HP:0000003)1.65489419
94Oligodactyly (HP:0012165)1.63903201
95Methylmalonic aciduria (HP:0012120)1.63117058
96Pancreatic islet-cell hyperplasia (HP:0004510)1.62594806
97Myokymia (HP:0002411)1.62371868
98Rhinitis (HP:0012384)1.62195692
99Absent septum pellucidum (HP:0001331)1.61822375
100Abnormality of chromosome stability (HP:0003220)1.61706826

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK33.37860945
2NEK13.16727048
3TNIK2.95723702
4CASK2.95105929
5FRK2.69737077
6MAP3K42.52090957
7BMPR1B2.50252651
8TRIM282.44381102
9BCR2.30144380
10MAP4K22.27321311
11MKNK21.94961976
12MAP2K71.94809281
13MAPK131.87263037
14INSRR1.79710767
15EPHA41.75824311
16MKNK11.73831768
17MARK11.73232816
18DYRK21.67948414
19NUAK11.66750097
20ACVR1B1.58046018
21PLK41.54213480
22BCKDK1.48954728
23ZAK1.47500118
24PBK1.41801280
25PNCK1.38442333
26CSNK1G21.36326024
27WNK41.35464232
28FGFR21.30036591
29ERBB31.29955251
30GRK11.28683010
31CSNK1G11.27678369
32PLK31.26806623
33PINK11.23323631
34STK391.23209342
35PLK21.19819590
36SRPK11.18132215
37PAK31.15351724
38MINK11.11823348
39PRKCG1.10104519
40CSNK1G31.09524457
41UHMK11.08220888
42ADRBK21.07058289
43STK38L1.06410687
44VRK11.04576516
45NTRK21.02401596
46BRD40.99444513
47CSNK1A1L0.98425581
48TSSK60.98116007
49TGFBR10.96200001
50FLT30.94998592
51PRKD30.91473005
52MAP2K40.91143887
53DYRK30.86461070
54CDC70.85202272
55NEK20.83354342
56PRKCE0.81855494
57TAF10.77623357
58PLK10.77161068
59NLK0.76834311
60DAPK20.75050330
61NTRK30.73587809
62OXSR10.73160119
63PASK0.71701588
64VRK20.71438393
65EPHB20.70633493
66MST40.63470709
67FGFR10.63399321
68TTK0.59116568
69DYRK1A0.55984925
70PDK20.55874945
71RPS6KA40.54986655
72CDK190.54703595
73CAMK2A0.54258321
74WEE10.54168804
75TIE10.53132146
76PHKG20.53091098
77PHKG10.53091098
78ATM0.53059407
79CSNK1E0.50501105
80STK160.49779178
81PRKACB0.49331106
82ATR0.48840218
83CSNK1A10.47623101
84NME10.43601404
85CDK50.41552488
86CSNK1D0.41459533
87STK30.40195384
88CCNB10.39706037
89ERBB40.37449801
90PRKACA0.37022407
91CDK30.36998700
92LATS10.36633548
93BRSK20.36533842
94PRKDC0.36466270
95CAMK10.35582482
96PAK60.34649699
97SGK2230.33288963
98SGK4940.33288963
99OBSCN0.31687878
100EIF2AK20.31594547

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.79182181
2Propanoate metabolism_Homo sapiens_hsa006402.56928131
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.55848283
4Protein export_Homo sapiens_hsa030602.45781753
5Steroid biosynthesis_Homo sapiens_hsa001002.41797944
6Butanoate metabolism_Homo sapiens_hsa006502.41337161
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.26371038
8Phototransduction_Homo sapiens_hsa047442.00768378
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.96288398
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.95260397
11Nicotine addiction_Homo sapiens_hsa050331.90043510
12Non-homologous end-joining_Homo sapiens_hsa034501.88298301
13Fanconi anemia pathway_Homo sapiens_hsa034601.72153756
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.67539424
15Oxidative phosphorylation_Homo sapiens_hsa001901.60090977
16Mismatch repair_Homo sapiens_hsa034301.56834943
17Homologous recombination_Homo sapiens_hsa034401.56790317
18Basal transcription factors_Homo sapiens_hsa030221.56268212
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.53939680
20Parkinsons disease_Homo sapiens_hsa050121.44825589
21RNA degradation_Homo sapiens_hsa030181.43312391
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.42072859
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.38816646
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.38535836
25Peroxisome_Homo sapiens_hsa041461.37320984
26RNA polymerase_Homo sapiens_hsa030201.33609878
27Fatty acid elongation_Homo sapiens_hsa000621.28957666
28Primary bile acid biosynthesis_Homo sapiens_hsa001201.27524975
29Taste transduction_Homo sapiens_hsa047421.23291778
30Base excision repair_Homo sapiens_hsa034101.19684175
31Basal cell carcinoma_Homo sapiens_hsa052171.19067548
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.18182842
33Huntingtons disease_Homo sapiens_hsa050161.17122941
34Hedgehog signaling pathway_Homo sapiens_hsa043401.16101046
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.15468658
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.15291148
37beta-Alanine metabolism_Homo sapiens_hsa004101.14528069
38Linoleic acid metabolism_Homo sapiens_hsa005911.10329675
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.10275556
40RNA transport_Homo sapiens_hsa030131.03047306
41Pyruvate metabolism_Homo sapiens_hsa006201.01596794
42Nucleotide excision repair_Homo sapiens_hsa034201.00309797
43Caffeine metabolism_Homo sapiens_hsa002320.99598618
44Ether lipid metabolism_Homo sapiens_hsa005650.98846545
45GABAergic synapse_Homo sapiens_hsa047270.98684094
46Tryptophan metabolism_Homo sapiens_hsa003800.97153799
47Nitrogen metabolism_Homo sapiens_hsa009100.96230134
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94995834
49Selenocompound metabolism_Homo sapiens_hsa004500.92842245
50Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.92287539
51Proteasome_Homo sapiens_hsa030500.91770037
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.88962439
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88830603
54Insulin secretion_Homo sapiens_hsa049110.88725388
55Circadian entrainment_Homo sapiens_hsa047130.87583759
56Fatty acid metabolism_Homo sapiens_hsa012120.87265022
57Dopaminergic synapse_Homo sapiens_hsa047280.86227229
58Glutamatergic synapse_Homo sapiens_hsa047240.84459642
59Vitamin B6 metabolism_Homo sapiens_hsa007500.84243487
60Olfactory transduction_Homo sapiens_hsa047400.83190488
61Morphine addiction_Homo sapiens_hsa050320.83017586
62Purine metabolism_Homo sapiens_hsa002300.82527191
63Hippo signaling pathway_Homo sapiens_hsa043900.82344244
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80632751
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80389594
66Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.76957521
67Cardiac muscle contraction_Homo sapiens_hsa042600.76401598
68Alzheimers disease_Homo sapiens_hsa050100.75785113
69Fatty acid degradation_Homo sapiens_hsa000710.75186686
70DNA replication_Homo sapiens_hsa030300.73155927
71Retinol metabolism_Homo sapiens_hsa008300.72408641
72Serotonergic synapse_Homo sapiens_hsa047260.71422868
73Fat digestion and absorption_Homo sapiens_hsa049750.70773936
74mRNA surveillance pathway_Homo sapiens_hsa030150.69455039
75Chemical carcinogenesis_Homo sapiens_hsa052040.68805635
76Long-term depression_Homo sapiens_hsa047300.68380438
77Metabolic pathways_Homo sapiens_hsa011000.67439076
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67288780
79Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67172893
80Cocaine addiction_Homo sapiens_hsa050300.66595517
81Axon guidance_Homo sapiens_hsa043600.66080434
82Glutathione metabolism_Homo sapiens_hsa004800.65284896
83Wnt signaling pathway_Homo sapiens_hsa043100.64942489
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64584864
85Regulation of autophagy_Homo sapiens_hsa041400.64441358
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63471641
87Oocyte meiosis_Homo sapiens_hsa041140.60098717
88Folate biosynthesis_Homo sapiens_hsa007900.59786484
89Lysine degradation_Homo sapiens_hsa003100.54962250
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.54915410
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54584024
92Spliceosome_Homo sapiens_hsa030400.52442649
93Amphetamine addiction_Homo sapiens_hsa050310.50985079
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50059298
95Vitamin digestion and absorption_Homo sapiens_hsa049770.48941223
96TGF-beta signaling pathway_Homo sapiens_hsa043500.48606479
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46423508
98Tight junction_Homo sapiens_hsa045300.45028622
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45017440
100Pyrimidine metabolism_Homo sapiens_hsa002400.44460537

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