ZNF335

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene enhances transcriptional activation by ligand-bound nuclear hormone receptors. However, it does this not by direct interaction with the receptor, but by direct interaction with the nuclear hormone receptor transcriptional coactivator NRC. The encoded protein may function by altering local chromatin structure. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)5.11196675
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.11196675
3positive regulation of gamma-delta T cell activation (GO:0046645)4.99916065
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.49450836
5negative regulation of erythrocyte differentiation (GO:0045647)4.48009851
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.31059338
7antigen processing and presentation of endogenous antigen (GO:0019883)4.22888599
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.19300904
9regulation of gamma-delta T cell activation (GO:0046643)4.13920103
10response to muramyl dipeptide (GO:0032495)3.99911404
11positive thymic T cell selection (GO:0045059)3.94084297
12regulation of gamma-delta T cell differentiation (GO:0045586)3.92853732
13leukocyte aggregation (GO:0070486)3.92274547
14positive regulation by symbiont of host defense response (GO:0052509)3.86888003
15modulation by symbiont of host defense response (GO:0052031)3.86888003
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.86888003
17modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.86888003
18positive regulation by organism of defense response of other organism involved in symbiotic interact3.86888003
19modulation by symbiont of host immune response (GO:0052553)3.86888003
20negative thymic T cell selection (GO:0045060)3.84180782
21thymic T cell selection (GO:0045061)3.82586333
22positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.80121064
23mannose metabolic process (GO:0006013)3.75193217
24regulation of B cell receptor signaling pathway (GO:0050855)3.73506687
25detection of bacterium (GO:0016045)3.71297828
26negative T cell selection (GO:0043383)3.70198637
27detection of other organism (GO:0098543)3.65708160
28response to peptidoglycan (GO:0032494)3.64078003
29macrophage activation involved in immune response (GO:0002281)3.64057866
30regulation of interferon-beta biosynthetic process (GO:0045357)3.57422473
31T cell selection (GO:0045058)3.53357401
32positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.45512131
33germinal center formation (GO:0002467)3.45304820
34negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.44162062
35NIK/NF-kappaB signaling (GO:0038061)3.42714233
36positive T cell selection (GO:0043368)3.40111418
37response to interleukin-15 (GO:0070672)3.32780280
38tolerance induction (GO:0002507)3.31463719
39histone H3-K36 demethylation (GO:0070544)3.29636117
40B cell receptor signaling pathway (GO:0050853)3.27578760
41positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.19291451
42regulation of histone H3-K27 methylation (GO:0061085)3.15379907
43negative regulation of interleukin-12 production (GO:0032695)3.05938465
44T cell migration (GO:0072678)3.04671040
45negative regulation of T cell mediated immunity (GO:0002710)3.02573177
46regulation of type I interferon-mediated signaling pathway (GO:0060338)3.01929312
47negative regulation of lymphocyte mediated immunity (GO:0002707)2.99960982
48neutrophil activation involved in immune response (GO:0002283)2.97419879
49cellular extravasation (GO:0045123)2.96730720
50negative regulation of innate immune response (GO:0045824)2.92808653
51response to type I interferon (GO:0034340)2.92683110
52regulation of T-helper 2 cell differentiation (GO:0045628)2.91974636
53cellular response to type I interferon (GO:0071357)2.91249541
54type I interferon signaling pathway (GO:0060337)2.91249541
55detection of external biotic stimulus (GO:0098581)2.90384285
56response to host (GO:0075136)2.86578511
57response to host defenses (GO:0052200)2.86578511
58response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.86578511
59negative regulation of leukocyte mediated immunity (GO:0002704)2.85740582
60cellular response to interleukin-15 (GO:0071350)2.84427562
61response to host immune response (GO:0052572)2.82936136
62response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.82936136
63myeloid cell activation involved in immune response (GO:0002275)2.82393445
64response to laminar fluid shear stress (GO:0034616)2.82369137
65regulation of mast cell degranulation (GO:0043304)2.81718675
66lipopolysaccharide-mediated signaling pathway (GO:0031663)2.72476560
67regulation of leukocyte degranulation (GO:0043300)2.72416358
68positive regulation of histone deacetylation (GO:0031065)2.70571319
69modulation by virus of host process (GO:0019054)2.68952017
70defense response to protozoan (GO:0042832)2.67730422
71positive regulation of Rap GTPase activity (GO:0032854)2.66392914
72regulation of ARF GTPase activity (GO:0032312)2.66328391
73regulation of alpha-beta T cell proliferation (GO:0046640)2.63735710
74positive regulation of granulocyte differentiation (GO:0030854)2.63441087
75immunoglobulin mediated immune response (GO:0016064)2.62336566
76regulation of myeloid leukocyte mediated immunity (GO:0002886)2.60985909
77positive regulation of protein deacetylation (GO:0090312)2.59640408
78modulation by symbiont of host cellular process (GO:0044068)2.59504338
79embryonic process involved in female pregnancy (GO:0060136)2.58993827
80regulation of T cell tolerance induction (GO:0002664)2.57141434
81B cell homeostasis (GO:0001782)2.56396581
82regulation of mast cell activation involved in immune response (GO:0033006)2.55918374
83response to protozoan (GO:0001562)2.55688314
84antigen processing and presentation via MHC class Ib (GO:0002475)2.55651938
85regulation of interleukin-2 biosynthetic process (GO:0045076)2.54804487
86negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.54647456
87signal complex assembly (GO:0007172)2.54309557
88negative regulation of interleukin-6 production (GO:0032715)2.53526556
89regulation of dendritic cell antigen processing and presentation (GO:0002604)2.53164230
90regulation of granulocyte differentiation (GO:0030852)2.52829141
91detection of biotic stimulus (GO:0009595)2.51812265
92T-helper cell differentiation (GO:0042093)2.51289747
93CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.51289747
94regulation of B cell differentiation (GO:0045577)2.50301427
95positive regulation of B cell differentiation (GO:0045579)2.50197907
963-UTR-mediated mRNA stabilization (GO:0070935)2.49339704
97Arp2/3 complex-mediated actin nucleation (GO:0034314)2.48846841
98histone H4 deacetylation (GO:0070933)2.48731978
99neutrophil activation (GO:0042119)2.48607136
100negative regulation of toll-like receptor signaling pathway (GO:0034122)2.47351978

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human3.53893940
2MYC_22102868_ChIP-Seq_BL_Human3.44480161
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.10570580
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.71355811
5KDM2B_26808549_Chip-Seq_SUP-B15_Human2.68774295
6TCF7_22412390_ChIP-Seq_EML_Mouse2.67134673
7KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.64096396
8LXR_22292898_ChIP-Seq_THP-1_Human2.48214709
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.48060150
10KDM2B_26808549_Chip-Seq_DND41_Human2.46297474
11MAF_26560356_Chip-Seq_TH1_Human2.46066679
12VDR_24763502_ChIP-Seq_THP-1_Human2.40755974
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.39309564
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.38163773
15ELK3_25401928_ChIP-Seq_HUVEC_Human2.31415023
16TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.28510155
17E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.26595744
18MAF_26560356_Chip-Seq_TH2_Human2.18746683
19UTX_26944678_Chip-Seq_JUKART_Human2.18104381
20KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.13222365
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.06998822
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.05281990
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.03903072
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.98450351
25RUNX1_22412390_ChIP-Seq_EML_Mouse1.94674557
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.91206855
27SCL_19346495_ChIP-Seq_HPC-7_Human1.91169868
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.90582358
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.85154639
30RACK7_27058665_Chip-Seq_MCF-7_Human1.80757622
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.80591537
32BRD4_27068464_Chip-Seq_AML-cells_Mouse1.78508220
33RUNX_20019798_ChIP-Seq_JUKART_Human1.76261529
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.75329554
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.72851753
36MYB_26560356_Chip-Seq_TH1_Human1.72124390
37KDM2B_26808549_Chip-Seq_JURKAT_Human1.71418336
38SPI1_23127762_ChIP-Seq_K562_Human1.69286846
39MYB_21317192_ChIP-Seq_ERMYB_Mouse1.69033709
40MYB_26560356_Chip-Seq_TH2_Human1.66388723
41IRF8_21731497_ChIP-ChIP_J774_Mouse1.64488014
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.55113712
43IRF8_27001747_Chip-Seq_BMDM_Mouse1.54295442
44P68_20966046_ChIP-Seq_HELA_Human1.53622762
45* SPI1_23547873_ChIP-Seq_NB4_Human1.52938288
46* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.52463611
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46769445
48BCOR_27268052_Chip-Seq_Bcells_Human1.43897568
49TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.43599707
50KDM2B_26808549_Chip-Seq_K562_Human1.42526817
51SA1_27219007_Chip-Seq_ERYTHROID_Human1.42003386
52GATA1_19941827_ChIP-Seq_MEL_Mouse1.40911528
53RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.39747319
54ELF1_20517297_ChIP-Seq_JURKAT_Human1.37898329
55CIITA_25753668_ChIP-Seq_RAJI_Human1.37685086
56PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.37400211
57RARG_19884340_ChIP-ChIP_MEFs_Mouse1.36794132
58STAT6_21828071_ChIP-Seq_BEAS2B_Human1.36786440
59SMC4_20622854_ChIP-Seq_HELA_Human1.36242341
60STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.35688309
61BCL6_27268052_Chip-Seq_Bcells_Human1.31909270
62GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31722838
63NCOR1_26117541_ChIP-Seq_K562_Human1.31223564
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29082450
65IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.25039267
66PU.1_20513432_ChIP-Seq_Bcells_Mouse1.24454368
67IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.24030952
68* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21164727
69GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21127050
70* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20096079
71TET1_21451524_ChIP-Seq_MESCs_Mouse1.19676534
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18585346
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16557316
74PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16539255
75CREB1_26743006_Chip-Seq_LNCaP_Human1.15992630
76* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15387058
77TP63_17297297_ChIP-ChIP_HaCaT_Human1.13761840
78ESR2_21235772_ChIP-Seq_MCF-7_Human1.13095419
79CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13079846
80RUNX1_27514584_Chip-Seq_MCF-7_Human1.11440124
81GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11122051
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10377416
83CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10146824
84BP1_19119308_ChIP-ChIP_Hs578T_Human1.09784323
85KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09600341
86CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07927705
87KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07686183
88GATA3_27048872_Chip-Seq_THYMUS_Human1.07656765
89GATA1_19941826_ChIP-Seq_K562_Human1.06162762
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05771512
91* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.05220601
92CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04333254
93P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03413876
94TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02160795
95UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01423980
96CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01397573
97SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00295250
98LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.98908501
99PKCTHETA_26484144_Chip-Seq_BREAST_Human0.98844167
100ETS1_21867929_ChIP-Seq_TH2_Mouse0.98724736

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to3.88949785
2MP0003763_abnormal_thymus_physiology3.22191037
3MP0003303_peritoneal_inflammation2.96693163
4MP0001835_abnormal_antigen_presentation2.72406304
5MP0003172_abnormal_lysosome_physiology2.55749102
6MP0001800_abnormal_humoral_immune2.52848017
7MP0000685_abnormal_immune_system2.52334649
8MP0005000_abnormal_immune_tolerance2.51168838
9MP0008260_abnormal_autophagy2.50673479
10MP0003724_increased_susceptibility_to2.45325927
11MP0001790_abnormal_immune_system2.42154974
12MP0005387_immune_system_phenotype2.42154974
13MP0005451_abnormal_body_composition2.38926216
14MP0009278_abnormal_bone_marrow2.34764785
15MP0005671_abnormal_response_to2.30350585
16MP0002419_abnormal_innate_immunity2.29855698
17MP0002723_abnormal_immune_serum2.27543392
18MP0005058_abnormal_lysosome_morphology2.27445137
19MP0005025_abnormal_response_to2.27303279
20MP0004947_skin_inflammation2.26642539
21MP0003300_gastrointestinal_ulcer2.20292590
22MP0002420_abnormal_adaptive_immunity2.16048446
23MP0002452_abnormal_antigen_presenting2.14122451
24MP0001819_abnormal_immune_cell2.13882351
25MP0009840_abnormal_foam_cell2.06135035
26MP0009333_abnormal_splenocyte_physiolog2.01821399
27MP0005076_abnormal_cell_differentiation1.99063640
28MP0002398_abnormal_bone_marrow1.98683338
29MP0001873_stomach_inflammation1.91279724
30MP0002405_respiratory_system_inflammati1.89569997
31MP0004381_abnormal_hair_follicle1.83732585
32MP0000703_abnormal_thymus_morphology1.79192022
33MP0000716_abnormal_immune_system1.78393180
34MP0009785_altered_susceptibility_to1.78220645
35MP0010155_abnormal_intestine_physiology1.70853300
36MP0001533_abnormal_skeleton_physiology1.69707793
37MP0003191_abnormal_cellular_cholesterol1.69232653
38MP0005310_abnormal_salivary_gland1.64966625
39MP0002722_abnormal_immune_system1.61689238
40MP0002148_abnormal_hypersensitivity_rea1.60053710
41MP0002396_abnormal_hematopoietic_system1.59262589
42MP0006082_CNS_inflammation1.52334490
43MP0002429_abnormal_blood_cell1.50113460
44MP0000689_abnormal_spleen_morphology1.48237365
45MP0004510_myositis1.44783181
46MP0005464_abnormal_platelet_physiology1.44738607
47MP0003828_pulmonary_edema1.43463958
48MP0002166_altered_tumor_susceptibility1.42113566
49MP0002933_joint_inflammation1.40821637
50MP0002009_preneoplasia1.40021017
51MP0003705_abnormal_hypodermis_morpholog1.38298618
52MP0000858_altered_metastatic_potential1.35275558
53MP0002998_abnormal_bone_remodeling1.35133146
54MP0001845_abnormal_inflammatory_respons1.33516496
55MP0003453_abnormal_keratinocyte_physiol1.32830473
56MP0004808_abnormal_hematopoietic_stem1.32359592
57MP0001348_abnormal_lacrimal_gland1.29677955
58MP0005397_hematopoietic_system_phenotyp1.27495461
59MP0001545_abnormal_hematopoietic_system1.27495461
60MP0001851_eye_inflammation1.19542697
61MP0003183_abnormal_peptide_metabolism1.19142092
62MP0000015_abnormal_ear_pigmentation1.18380249
63MP0008469_abnormal_protein_level1.16985473
64MP0003091_abnormal_cell_migration1.14812050
65MP0003866_abnormal_defecation1.11566518
66MP0001853_heart_inflammation1.08997535
67MP0001849_ear_inflammation1.08494377
68MP0000465_gastrointestinal_hemorrhage1.01101974
69MP0002132_abnormal_respiratory_system1.00565401
70MP0005409_darkened_coat_color1.00508762
71MP0008961_abnormal_basal_metabolism1.00257546
72MP0004185_abnormal_adipocyte_glucose0.98950454
73MP0003045_fibrosis0.92073322
74MP0005666_abnormal_adipose_tissue0.88355957
75MP0002796_impaired_skin_barrier0.86939337
76MP0002006_tumorigenesis0.85289877
77MP0003656_abnormal_erythrocyte_physiolo0.83646417
78MP0001986_abnormal_taste_sensitivity0.82131488
79MP0005375_adipose_tissue_phenotype0.81927161
80MP0000490_abnormal_crypts_of0.80725218
81MP0005083_abnormal_biliary_tract0.80490570
82MP0002254_reproductive_system_inflammat0.80137800
83MP0009115_abnormal_fat_cell0.80118030
84MP0009931_abnormal_skin_appearance0.77769679
85MP0005621_abnormal_cell_physiology0.75817580
86MP0009764_decreased_sensitivity_to0.75727325
87MP0005390_skeleton_phenotype0.75518522
88MP0003566_abnormal_cell_adhesion0.74253579
89MP0003075_altered_response_to0.73665185
90MP0002019_abnormal_tumor_incidence0.73624546
91MP0003448_altered_tumor_morphology0.72299729
92MP0000604_amyloidosis0.68570454
93MP0000003_abnormal_adipose_tissue0.66271957
94MP0002970_abnormal_white_adipose0.65948658
95MP0008874_decreased_physiological_sensi0.64659353
96MP0000249_abnormal_blood_vessel0.64586124
97MP0003329_amyloid_beta_deposits0.63141619
98MP0004130_abnormal_muscle_cell0.62699069
99MP0003795_abnormal_bone_structure0.62530810
100MP0005166_decreased_susceptibility_to0.62339304

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.17065871
2Recurrent abscess formation (HP:0002722)3.82149555
3Recurrent bacterial skin infections (HP:0005406)3.81182075
4Abnormality of macrophages (HP:0004311)3.47593661
5Myositis (HP:0100614)3.46435479
6Increased IgE level (HP:0003212)3.45358098
7Recurrent fungal infections (HP:0002841)3.38203331
8Colitis (HP:0002583)3.13937540
9Broad face (HP:0000283)3.12918332
10Pustule (HP:0200039)3.10594799
11Gastrointestinal infarctions (HP:0005244)3.07520433
12Abnormal delayed hypersensitivity skin test (HP:0002963)2.99725890
13Gastrointestinal inflammation (HP:0004386)2.99222727
14Orchitis (HP:0100796)2.97342076
15Stomatitis (HP:0010280)2.96332218
16Abnormality of the fingertips (HP:0001211)2.91414480
17Mediastinal lymphadenopathy (HP:0100721)2.91193486
18Cellulitis (HP:0100658)2.85612919
19Chronic mucocutaneous candidiasis (HP:0002728)2.84878780
20Recurrent cutaneous fungal infections (HP:0011370)2.84878780
21Elevated erythrocyte sedimentation rate (HP:0003565)2.82971644
22Panhypogammaglobulinemia (HP:0003139)2.82668279
23Inflammation of the large intestine (HP:0002037)2.82400025
24Meningitis (HP:0001287)2.79036250
25Recurrent viral infections (HP:0004429)2.77433199
26Optic neuritis (HP:0100653)2.76507024
27Retrobulbar optic neuritis (HP:0100654)2.76507024
28Recurrent skin infections (HP:0001581)2.75651190
29Obstructive lung disease (HP:0006536)2.68479984
30Chronic obstructive pulmonary disease (HP:0006510)2.68479984
31Gingivitis (HP:0000230)2.66200626
32Gastrointestinal stroma tumor (HP:0100723)2.64359395
33Thin bony cortex (HP:0002753)2.63506186
34Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.60669321
35Vasculitis (HP:0002633)2.57786633
36Increased cerebral lipofuscin (HP:0011813)2.55371429
37Increased neuronal autofluorescent lipopigment (HP:0002074)2.41334859
38Dysostosis multiplex (HP:0000943)2.37301111
39Loss of speech (HP:0002371)2.34611121
40Spontaneous hematomas (HP:0007420)2.33821956
41T lymphocytopenia (HP:0005403)2.31568255
42Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.29039401
43Slow saccadic eye movements (HP:0000514)2.28913927
44Obstructive sleep apnea (HP:0002870)2.28884971
45Prolonged bleeding time (HP:0003010)2.27049856
46Lymphopenia (HP:0001888)2.25462310
47Chest pain (HP:0100749)2.23397664
48Hypochromic anemia (HP:0001931)2.22048036
49Recurrent gram-negative bacterial infections (HP:0005420)2.21666923
50Emphysema (HP:0002097)2.16779126
51Abnormality of T cells (HP:0002843)2.15728995
52Verrucae (HP:0200043)2.14201137
53Papilloma (HP:0012740)2.14201137
54Epistaxis (HP:0000421)2.11228837
55Granulocytopenia (HP:0001913)2.09495184
56Abnormality of cells of the lymphoid lineage (HP:0012140)2.09418263
57Encephalitis (HP:0002383)2.07744880
58Keratoconjunctivitis sicca (HP:0001097)2.07296056
59Abnormality of T cell number (HP:0011839)2.06751395
60Abnormality of T cell physiology (HP:0011840)2.05175337
61Abnormality of polysaccharide metabolism (HP:0011012)2.04280814
62Abnormality of glycosaminoglycan metabolism (HP:0004371)2.04280814
63Abnormality of mucopolysaccharide metabolism (HP:0011020)2.04280814
64Agammaglobulinemia (HP:0004432)2.02686164
65Hemoptysis (HP:0002105)2.02403389
66Interstitial pulmonary disease (HP:0006530)2.01956992
67Hemorrhage of the eye (HP:0011885)2.00841635
68Pulmonary infiltrates (HP:0002113)1.99065555
69Severe visual impairment (HP:0001141)1.96768248
70Easy fatigability (HP:0003388)1.94356475
71Urticaria (HP:0001025)1.93992504
72Basal cell carcinoma (HP:0002671)1.93642548
73Keratoconjunctivitis (HP:0001096)1.93572971
74Fatigue (HP:0012378)1.92881244
75Nuclear cataract (HP:0100018)1.92226807
76Abnormality of the columella (HP:0009929)1.91398073
77Osteomyelitis (HP:0002754)1.91020035
78Mucopolysacchariduria (HP:0008155)1.89579579
79Urinary glycosaminoglycan excretion (HP:0003541)1.89579579
80Neuronal loss in central nervous system (HP:0002529)1.86279402
81Distal lower limb amyotrophy (HP:0008944)1.84565112
82Restrictive lung disease (HP:0002091)1.84114439
83Increased serum ferritin (HP:0003281)1.82974936
84Seborrheic dermatitis (HP:0001051)1.78710685
85Centrally nucleated skeletal muscle fibers (HP:0003687)1.78516678
86Leukocytosis (HP:0001974)1.77528688
87Long palpebral fissure (HP:0000637)1.73320478
88Arterial thrombosis (HP:0004420)1.72856162
89Increased connective tissue (HP:0009025)1.72591759
90Acute hepatic failure (HP:0006554)1.72274345
91Sepsis (HP:0100806)1.71357326
92Severe combined immunodeficiency (HP:0004430)1.70130998
93Hypertensive crisis (HP:0100735)1.69991825
94Malnutrition (HP:0004395)1.68730686
95Deep palmar crease (HP:0006191)1.68307244
96Viral hepatitis (HP:0006562)1.67927753
97J-shaped sella turcica (HP:0002680)1.67332406
98Papilledema (HP:0001085)1.66744018
99Asymmetric septal hypertrophy (HP:0001670)1.65852428
100Cerebral aneurysm (HP:0004944)1.65620987

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.53621100
2PRPF4B3.41882332
3TRIB33.36353682
4RIPK42.62562938
5CDK122.61117478
6ERN12.57279217
7SMG12.24749873
8SIK12.23635199
9MAP2K32.23283459
10IRAK42.21332286
11TYK21.93368115
12MAP3K141.82985366
13ZAP701.81416615
14BLK1.81009132
15GRK61.80574476
16IRAK31.79843896
17TNK21.76018136
18MAP3K131.74109376
19TBK11.72579075
20SIK21.68676488
21ICK1.67743640
22EPHB11.63263454
23EEF2K1.58975452
24SIK31.58187461
25TAOK11.47734119
26FGFR41.46063639
27FES1.45258926
28MARK21.41752465
29IKBKE1.41053079
30MAP3K101.40146271
31TXK1.37924537
32JAK31.37408471
33CSK1.36102740
34JAK11.23170327
35MAP3K11.22508908
36MAP3K31.22235515
37BTK1.21039576
38MAP3K111.21036574
39CDC42BPA1.18522658
40KSR21.17221971
41HCK1.16327006
42BRD41.15291191
43IKBKB1.10423849
44MAP3K71.09549045
45MAPK111.09157278
46PDPK11.08043113
47TAOK21.05512639
48PDK11.05287997
49PRKD21.05286447
50MAP2K61.05183193
51CDK40.96856948
52SYK0.94624554
53TESK20.89298065
54LCK0.85505894
55MAPK120.85143976
56HIPK20.84970134
57STK380.83421757
58RIPK10.82924980
59ITK0.81334357
60CSF1R0.80498706
61IRAK20.79704451
62MTOR0.76775537
63FGFR30.75398253
64MARK30.74080101
65CHUK0.74071776
66TTN0.73958615
67PKN20.73536686
68MAP2K20.73135772
69CAMK1D0.72930519
70LYN0.71113102
71MELK0.69351532
72RPS6KL10.69330626
73RPS6KC10.69330626
74RPS6KA20.68759823
75FGR0.68039820
76PTK60.67173137
77JAK20.66675269
78BMX0.64406299
79MAPK70.61128555
80IRAK10.59731321
81CAMKK10.57657842
82RPS6KA60.53861185
83STK100.52814568
84TYRO30.49684624
85PIM10.49615245
86RET0.48817154
87SGK30.48004650
88TAOK30.46466570
89CDK60.46350255
90YES10.45183599
91KIT0.44629024
92RAF10.41402585
93DYRK1B0.41067755
94PRKD30.40257592
95NME20.39589541
96RPS6KA10.38908815
97MAP3K60.35951108
98NEK60.35050093
99MATK0.34335081
100MAPKAPK20.33786301

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046622.41430857
2Osteoclast differentiation_Homo sapiens_hsa043802.28776597
3Acute myeloid leukemia_Homo sapiens_hsa052212.28692847
4Other glycan degradation_Homo sapiens_hsa005112.28550191
5Primary immunodeficiency_Homo sapiens_hsa053402.07454605
6T cell receptor signaling pathway_Homo sapiens_hsa046602.00858870
7Leishmaniasis_Homo sapiens_hsa051401.91703300
8Toll-like receptor signaling pathway_Homo sapiens_hsa046201.81575739
9Non-small cell lung cancer_Homo sapiens_hsa052231.75579684
10Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.75550842
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.75530476
12Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.73863684
13Chronic myeloid leukemia_Homo sapiens_hsa052201.67447726
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.63807490
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.63591473
16Measles_Homo sapiens_hsa051621.58452594
17Influenza A_Homo sapiens_hsa051641.53304347
18Allograft rejection_Homo sapiens_hsa053301.52029901
19TNF signaling pathway_Homo sapiens_hsa046681.51880957
20VEGF signaling pathway_Homo sapiens_hsa043701.50078310
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.49687206
22Hepatitis B_Homo sapiens_hsa051611.45032109
23Toxoplasmosis_Homo sapiens_hsa051451.44733962
24Graft-versus-host disease_Homo sapiens_hsa053321.43826011
25Notch signaling pathway_Homo sapiens_hsa043301.43561630
26Tuberculosis_Homo sapiens_hsa051521.40903349
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.39555720
28Autoimmune thyroid disease_Homo sapiens_hsa053201.35903622
29Herpes simplex infection_Homo sapiens_hsa051681.35448699
30Pancreatic cancer_Homo sapiens_hsa052121.30086643
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.29784537
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22072027
33Hepatitis C_Homo sapiens_hsa051601.22057809
34Neurotrophin signaling pathway_Homo sapiens_hsa047221.21612466
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.21556566
36Chemokine signaling pathway_Homo sapiens_hsa040621.15702803
37Endometrial cancer_Homo sapiens_hsa052131.15102694
38mTOR signaling pathway_Homo sapiens_hsa041501.14164968
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.13111082
40Staphylococcus aureus infection_Homo sapiens_hsa051501.12906514
41Renal cell carcinoma_Homo sapiens_hsa052111.11561064
42Apoptosis_Homo sapiens_hsa042101.08091745
43Viral myocarditis_Homo sapiens_hsa054161.07315233
44Hematopoietic cell lineage_Homo sapiens_hsa046401.06268910
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05519358
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.05245449
47Inositol phosphate metabolism_Homo sapiens_hsa005621.03802945
48Intestinal immune network for IgA production_Homo sapiens_hsa046721.03307914
49Prolactin signaling pathway_Homo sapiens_hsa049171.02713183
50Malaria_Homo sapiens_hsa051440.96790509
51Viral carcinogenesis_Homo sapiens_hsa052030.96597553
52Type I diabetes mellitus_Homo sapiens_hsa049400.96419949
53Antigen processing and presentation_Homo sapiens_hsa046120.95078872
54Bladder cancer_Homo sapiens_hsa052190.94923029
55ErbB signaling pathway_Homo sapiens_hsa040120.94876729
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.94382302
57FoxO signaling pathway_Homo sapiens_hsa040680.93115070
58Platelet activation_Homo sapiens_hsa046110.92644959
59Choline metabolism in cancer_Homo sapiens_hsa052310.92332077
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.92124702
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.90899097
62Shigellosis_Homo sapiens_hsa051310.90614014
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.89445700
64Insulin resistance_Homo sapiens_hsa049310.88749756
65Epstein-Barr virus infection_Homo sapiens_hsa051690.88143117
66Colorectal cancer_Homo sapiens_hsa052100.88035698
67HTLV-I infection_Homo sapiens_hsa051660.85752417
68Dorso-ventral axis formation_Homo sapiens_hsa043200.85434541
69Prostate cancer_Homo sapiens_hsa052150.85002883
70GnRH signaling pathway_Homo sapiens_hsa049120.84945235
71Lysosome_Homo sapiens_hsa041420.84931876
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.84581646
73Endocytosis_Homo sapiens_hsa041440.82342435
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81189418
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80213124
76Glioma_Homo sapiens_hsa052140.79284961
77Insulin signaling pathway_Homo sapiens_hsa049100.77647560
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77554148
79Pertussis_Homo sapiens_hsa051330.74139175
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73846109
81MAPK signaling pathway_Homo sapiens_hsa040100.72189860
82Legionellosis_Homo sapiens_hsa051340.71386109
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.69004700
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66622510
85African trypanosomiasis_Homo sapiens_hsa051430.66329657
86Estrogen signaling pathway_Homo sapiens_hsa049150.65260170
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63604505
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61273217
89Type II diabetes mellitus_Homo sapiens_hsa049300.60783420
90Small cell lung cancer_Homo sapiens_hsa052220.60094218
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59758318
92Salmonella infection_Homo sapiens_hsa051320.59741860
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59348744
94HIF-1 signaling pathway_Homo sapiens_hsa040660.58126938
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56147726
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54974012
97Fructose and mannose metabolism_Homo sapiens_hsa000510.53045743
98Thyroid cancer_Homo sapiens_hsa052160.52197870
99Asthma_Homo sapiens_hsa053100.51670651
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.50842388

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »