ZNF33A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.25094281
2nucleobase catabolic process (GO:0046113)5.29105341
3neural tube formation (GO:0001841)4.61514768
4regulation of protein glycosylation (GO:0060049)4.21348716
5negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.10963543
6negative regulation of translation, ncRNA-mediated (GO:0040033)4.10963543
7regulation of translation, ncRNA-mediated (GO:0045974)4.10963543
8establishment of protein localization to Golgi (GO:0072600)3.79734021
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.76922812
10histone H3-K4 trimethylation (GO:0080182)3.76758202
11protein targeting to Golgi (GO:0000042)3.60198003
12peptidyl-lysine trimethylation (GO:0018023)3.59143054
13protein K11-linked deubiquitination (GO:0035871)3.50059075
14pre-miRNA processing (GO:0031054)3.49219005
15presynaptic membrane assembly (GO:0097105)3.49022310
16intraciliary transport (GO:0042073)3.46970929
17presynaptic membrane organization (GO:0097090)3.33494399
18regulation of mitotic spindle checkpoint (GO:1903504)3.31775366
19regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.31775366
20retrograde transport, vesicle recycling within Golgi (GO:0000301)3.31663190
21olfactory bulb development (GO:0021772)3.31183058
22epithelial cilium movement (GO:0003351)3.30625772
23monoubiquitinated protein deubiquitination (GO:0035520)3.28122240
24mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.26735938
25positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.26735938
26regulation of gene expression by genetic imprinting (GO:0006349)3.23686668
27DNA double-strand break processing (GO:0000729)3.21848652
28kidney morphogenesis (GO:0060993)3.15775627
29protein localization to cilium (GO:0061512)3.06474149
30regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.04850999
31regulation of cilium movement (GO:0003352)3.03991487
32cilium movement (GO:0003341)3.03246478
33single strand break repair (GO:0000012)3.01447512
34phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.96405464
35nonmotile primary cilium assembly (GO:0035058)2.95083982
36axoneme assembly (GO:0035082)2.94485669
37retinal ganglion cell axon guidance (GO:0031290)2.89935437
38head development (GO:0060322)2.89565124
39cilium morphogenesis (GO:0060271)2.87941346
40negative regulation of DNA recombination (GO:0045910)2.85432399
41histone H3-K9 methylation (GO:0051567)2.84562222
42histone H3-K9 modification (GO:0061647)2.83442776
43genetic imprinting (GO:0071514)2.81308542
44behavioral response to nicotine (GO:0035095)2.80621491
45negative regulation of cytosolic calcium ion concentration (GO:0051481)2.76859205
46negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.76660364
47regulation of telomere maintenance (GO:0032204)2.75803524
48protein localization to Golgi apparatus (GO:0034067)2.74415840
49positive regulation of growth hormone secretion (GO:0060124)2.72595176
50L-fucose catabolic process (GO:0042355)2.72105795
51fucose catabolic process (GO:0019317)2.72105795
52L-fucose metabolic process (GO:0042354)2.72105795
53protein targeting to lysosome (GO:0006622)2.69891414
54establishment of protein localization to vacuole (GO:0072666)2.69891414
55protein targeting to vacuole (GO:0006623)2.69891414
56cilium or flagellum-dependent cell motility (GO:0001539)2.67253244
57cilium organization (GO:0044782)2.66959790
58regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.66203621
59axonal fasciculation (GO:0007413)2.65655836
60mechanosensory behavior (GO:0007638)2.65208029
61cerebellar Purkinje cell differentiation (GO:0021702)2.64170413
62regulation of hexokinase activity (GO:1903299)2.62941817
63regulation of glucokinase activity (GO:0033131)2.62941817
64cilium assembly (GO:0042384)2.62818186
65photoreceptor cell maintenance (GO:0045494)2.61886918
66synapse assembly (GO:0007416)2.59879157
67rRNA catabolic process (GO:0016075)2.58630403
68ncRNA catabolic process (GO:0034661)2.58426426
69microtubule anchoring (GO:0034453)2.57286218
70peptidyl-lysine methylation (GO:0018022)2.56822774
71positive regulation of oligodendrocyte differentiation (GO:0048714)2.56671827
72negative regulation of DNA-dependent DNA replication (GO:2000104)2.56405944
73retinal cone cell development (GO:0046549)2.55236693
74neuron recognition (GO:0008038)2.55118593
75positive regulation of mRNA processing (GO:0050685)2.54636306
76positive regulation of amino acid transport (GO:0051957)2.54597797
77central nervous system projection neuron axonogenesis (GO:0021952)2.53749652
78activated T cell proliferation (GO:0050798)2.51672532
79adaptation of signaling pathway (GO:0023058)2.50793663
80positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.49799134
81dendritic spine morphogenesis (GO:0060997)2.48660679
82auditory behavior (GO:0031223)2.46134945
83glycerophospholipid catabolic process (GO:0046475)2.45961759
84detection of light stimulus involved in visual perception (GO:0050908)2.44684705
85detection of light stimulus involved in sensory perception (GO:0050962)2.44684705
86negative regulation of cAMP-mediated signaling (GO:0043951)2.43347502
87establishment of mitochondrion localization (GO:0051654)2.41343508
88establishment of nucleus localization (GO:0040023)2.40252531
89cytoplasmic mRNA processing body assembly (GO:0033962)2.39359355
90transmission of nerve impulse (GO:0019226)2.38513278
91central nervous system neuron axonogenesis (GO:0021955)2.37973273
92tachykinin receptor signaling pathway (GO:0007217)2.37655869
93protein polyglutamylation (GO:0018095)2.37570776
94glycosphingolipid biosynthetic process (GO:0006688)2.36919387
95G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.36433389
96embryonic epithelial tube formation (GO:0001838)2.31860536
97centriole replication (GO:0007099)2.31236107
98vocalization behavior (GO:0071625)2.28999808
99atrial cardiac muscle cell action potential (GO:0086014)2.28288969
100regulation of collateral sprouting (GO:0048670)2.27547600

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IGF1R_20145208_ChIP-Seq_DFB_Human3.38048352
2POU3F2_20337985_ChIP-ChIP_501MEL_Human3.16181007
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.08894091
4GBX2_23144817_ChIP-Seq_PC3_Human2.91002366
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.77659308
6ZNF274_21170338_ChIP-Seq_K562_Hela2.66006785
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.58741217
8TAF15_26573619_Chip-Seq_HEK293_Human2.49490343
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.49107361
10EZH2_22144423_ChIP-Seq_EOC_Human2.36675171
11EWS_26573619_Chip-Seq_HEK293_Human2.31828809
12P300_19829295_ChIP-Seq_ESCs_Human2.30010714
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.28282173
14FUS_26573619_Chip-Seq_HEK293_Human2.24679469
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.24186756
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.23839657
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.18930158
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.12261066
19SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.10973055
20AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.07655652
21VDR_22108803_ChIP-Seq_LS180_Human1.99766044
22ER_23166858_ChIP-Seq_MCF-7_Human1.90309919
23POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.83075534
24TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83075534
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78339340
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76992837
27SMAD4_21799915_ChIP-Seq_A2780_Human1.75069972
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.74823926
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.74536402
30MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.70988519
31OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64433680
32SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63055282
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62333585
34STAT3_23295773_ChIP-Seq_U87_Human1.59794865
35CBP_20019798_ChIP-Seq_JUKART_Human1.58855204
36IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.58855204
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58030620
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.56410085
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.54201829
40* TCF4_23295773_ChIP-Seq_U87_Human1.52173494
41EZH2_27294783_Chip-Seq_NPCs_Mouse1.52144824
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51783816
43TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.51292169
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.46287361
45IRF1_19129219_ChIP-ChIP_H3396_Human1.44959126
46NANOG_18555785_Chip-Seq_ESCs_Mouse1.44803438
47NFE2_27457419_Chip-Seq_LIVER_Mouse1.42919564
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42385057
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42219287
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41984101
51AR_25329375_ChIP-Seq_VCAP_Human1.41177971
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37885018
53BCAT_22108803_ChIP-Seq_LS180_Human1.36943548
54REST_21632747_ChIP-Seq_MESCs_Mouse1.36198759
55EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.35978542
56RUNX2_22187159_ChIP-Seq_PCA_Human1.35380719
57P53_22387025_ChIP-Seq_ESCs_Mouse1.33334730
58CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.31819600
59TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.31640544
60TCF4_22108803_ChIP-Seq_LS180_Human1.30424795
61E2F1_18555785_Chip-Seq_ESCs_Mouse1.30150728
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29767523
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25834742
64RNF2_27304074_Chip-Seq_NSC_Mouse1.25758651
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24308328
66FLI1_21867929_ChIP-Seq_TH2_Mouse1.24208492
67PRDM14_20953172_ChIP-Seq_ESCs_Human1.20842571
68CMYC_18555785_Chip-Seq_ESCs_Mouse1.20234884
69KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19692554
70SUZ12_18555785_Chip-Seq_ESCs_Mouse1.16656335
71CBX2_27304074_Chip-Seq_ESCs_Mouse1.14757494
72P300_18555785_Chip-Seq_ESCs_Mouse1.14184211
73CRX_20693478_ChIP-Seq_RETINA_Mouse1.14106677
74GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14050030
75BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13591585
76NANOG_19829295_ChIP-Seq_ESCs_Human1.11796868
77SOX2_19829295_ChIP-Seq_ESCs_Human1.11796868
78TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11458109
79TP53_22573176_ChIP-Seq_HFKS_Human1.11180331
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10744375
81TAL1_26923725_Chip-Seq_HPCs_Mouse1.10236768
82OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09839087
83SOX2_21211035_ChIP-Seq_LN229_Gbm1.08476099
84E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.08328750
85STAT3_18555785_Chip-Seq_ESCs_Mouse1.07792807
86TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07460545
87EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06901825
88HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.05696879
89TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05102033
90CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03637479
91SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03619114
92ELK1_19687146_ChIP-ChIP_HELA_Human1.03380811
93CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.03118451
94ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02550423
95* JUN_21703547_ChIP-Seq_K562_Human1.01852623
96FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01082480
97P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00062756
98OCT4_18555785_Chip-Seq_ESCs_Mouse0.99828776
99ARNT_22903824_ChIP-Seq_MCF-7_Human0.99640172
100AR_21572438_ChIP-Seq_LNCaP_Human0.99570237

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting5.44411270
2MP0000569_abnormal_digit_pigmentation4.40902192
3MP0008877_abnormal_DNA_methylation4.05859187
4MP0003121_genomic_imprinting3.26030286
5MP0008057_abnormal_DNA_replication3.17179459
6MP0003122_maternal_imprinting3.05192018
7MP0001984_abnormal_olfaction2.31850711
8MP0003890_abnormal_embryonic-extraembry2.18770845
9MP0003880_abnormal_central_pattern2.16588207
10MP0006276_abnormal_autonomic_nervous2.15846990
11MP0001188_hyperpigmentation2.05340819
12MP0002909_abnormal_adrenal_gland1.95544289
13MP0002102_abnormal_ear_morphology1.84127956
14MP0000778_abnormal_nervous_system1.78951880
15MP0001529_abnormal_vocalization1.77903280
16MP0002009_preneoplasia1.72768765
17MP0003724_increased_susceptibility_to1.58025583
18MP0006072_abnormal_retinal_apoptosis1.54905428
19MP0005248_abnormal_Harderian_gland1.54032753
20MP0005551_abnormal_eye_electrophysiolog1.53216462
21MP0005423_abnormal_somatic_nervous1.51569131
22MP0005645_abnormal_hypothalamus_physiol1.46902715
23MP0005499_abnormal_olfactory_system1.46150331
24MP0005394_taste/olfaction_phenotype1.46150331
25MP0004133_heterotaxia1.39934137
26MP0002277_abnormal_respiratory_mucosa1.39475658
27MP0001486_abnormal_startle_reflex1.36719729
28MP0002928_abnormal_bile_duct1.33506489
29MP0005253_abnormal_eye_physiology1.32656468
30MP0002638_abnormal_pupillary_reflex1.30735494
31MP0000427_abnormal_hair_cycle1.27825304
32MP0005084_abnormal_gallbladder_morpholo1.27432354
33MP0002735_abnormal_chemical_nociception1.25846308
34MP0004043_abnormal_pH_regulation1.25258269
35MP0002837_dystrophic_cardiac_calcinosis1.22930291
36MP0002822_catalepsy1.22874610
37MP0008789_abnormal_olfactory_epithelium1.22732102
38MP0004142_abnormal_muscle_tone1.22080515
39MP0000631_abnormal_neuroendocrine_gland1.21799788
40MP0008058_abnormal_DNA_repair1.20252244
41MP0009046_muscle_twitch1.19719085
42MP0003635_abnormal_synaptic_transmissio1.18138401
43MP0002653_abnormal_ependyma_morphology1.17494843
44MP0002557_abnormal_social/conspecific_i1.16869375
45MP0003195_calcinosis1.15773634
46MP0001485_abnormal_pinna_reflex1.15209344
47MP0002063_abnormal_learning/memory/cond1.14732095
48MP0002272_abnormal_nervous_system1.14222584
49MP0006292_abnormal_olfactory_placode1.13776380
50MP0004270_analgesia1.13364221
51MP0005379_endocrine/exocrine_gland_phen1.11668115
52MP0002138_abnormal_hepatobiliary_system1.10656032
53MP0002572_abnormal_emotion/affect_behav1.09633592
54MP0002067_abnormal_sensory_capabilities1.09612034
55MP0009745_abnormal_behavioral_response1.09299942
56MP0002734_abnormal_mechanical_nocicepti1.08782587
57MP0005386_behavior/neurological_phenoty1.08732120
58MP0004924_abnormal_behavior1.08732120
59MP0002163_abnormal_gland_morphology1.07831413
60MP0003123_paternal_imprinting1.05184455
61MP0004811_abnormal_neuron_physiology1.02151327
62MP0001968_abnormal_touch/_nociception1.01549681
63MP0001970_abnormal_pain_threshold0.99635490
64MP0001293_anophthalmia0.98760277
65MP0003221_abnormal_cardiomyocyte_apopto0.98735856
66MP0001986_abnormal_taste_sensitivity0.94940155
67MP0002184_abnormal_innervation0.93098063
68MP0010386_abnormal_urinary_bladder0.92782104
69MP0004145_abnormal_muscle_electrophysio0.92157098
70MP0002751_abnormal_autonomic_nervous0.91421731
71MP0000955_abnormal_spinal_cord0.91402847
72MP0003567_abnormal_fetal_cardiomyocyte0.85753585
73MP0005187_abnormal_penis_morphology0.85567000
74MP0004147_increased_porphyrin_level0.85274370
75MP0004859_abnormal_synaptic_plasticity0.85218604
76MP0003011_delayed_dark_adaptation0.83851314
77MP0002882_abnormal_neuron_morphology0.83209175
78MP0000383_abnormal_hair_follicle0.82719390
79MP0002733_abnormal_thermal_nociception0.82516358
80MP0004742_abnormal_vestibular_system0.82220128
81MP0002752_abnormal_somatic_nervous0.80505434
82MP0008995_early_reproductive_senescence0.76612950
83MP0001919_abnormal_reproductive_system0.76592231
84MP0001501_abnormal_sleep_pattern0.75994209
85MP0003119_abnormal_digestive_system0.75714129
86MP0003252_abnormal_bile_duct0.75696309
87MP0005266_abnormal_metabolism0.74532935
88MP0000647_abnormal_sebaceous_gland0.74010524
89MP0008872_abnormal_physiological_respon0.72545795
90MP0002152_abnormal_brain_morphology0.72342221
91MP0005195_abnormal_posterior_eye0.72273838
92MP0005075_abnormal_melanosome_morpholog0.71691797
93MP0003698_abnormal_male_reproductive0.71664841
94MP0002064_seizures0.70620649
95MP0002069_abnormal_eating/drinking_beha0.67964812
96MP0004885_abnormal_endolymph0.66724729
97MP0005391_vision/eye_phenotype0.65770840
98MP0009703_decreased_birth_body0.64269116
99MP0003861_abnormal_nervous_system0.63840305
100MP0002693_abnormal_pancreas_physiology0.62844701

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.48008256
2Nephronophthisis (HP:0000090)3.31206457
3Medial flaring of the eyebrow (HP:0010747)3.29114853
4Pancreatic fibrosis (HP:0100732)3.08301298
5Gait imbalance (HP:0002141)3.05482483
6Abnormality of the renal medulla (HP:0100957)2.90106554
7Congenital primary aphakia (HP:0007707)2.89304185
8Hyperventilation (HP:0002883)2.80935176
9Type II lissencephaly (HP:0007260)2.78881764
10Molar tooth sign on MRI (HP:0002419)2.76983609
11Abnormality of midbrain morphology (HP:0002418)2.76983609
12True hermaphroditism (HP:0010459)2.74573211
13Hepatoblastoma (HP:0002884)2.72617361
14Abnormality of the labia minora (HP:0012880)2.72546001
15Volvulus (HP:0002580)2.72010699
16Calf muscle hypertrophy (HP:0008981)2.70135213
17Nephrogenic diabetes insipidus (HP:0009806)2.69191622
18Drooling (HP:0002307)2.67964410
19Lissencephaly (HP:0001339)2.67766794
20Broad-based gait (HP:0002136)2.67466811
21Papillary thyroid carcinoma (HP:0002895)2.65760393
22Genital tract atresia (HP:0001827)2.64770173
23Genetic anticipation (HP:0003743)2.63598111
24Progressive inability to walk (HP:0002505)2.63392612
25Vaginal atresia (HP:0000148)2.63158869
26Excessive salivation (HP:0003781)2.58909315
27Tubulointerstitial nephritis (HP:0001970)2.56997957
28Abnormal hair whorl (HP:0010721)2.55292468
29Hip dysplasia (HP:0001385)2.51189455
30Abnormality of the renal cortex (HP:0011035)2.51101079
31Chronic hepatic failure (HP:0100626)2.49870896
32Agitation (HP:0000713)2.46556708
33Muscle hypertrophy of the lower extremities (HP:0008968)2.37351979
34Pachygyria (HP:0001302)2.33884081
35Abolished electroretinogram (ERG) (HP:0000550)2.30525654
36Poor coordination (HP:0002370)2.30438472
37Methylmalonic acidemia (HP:0002912)2.29211486
38Intestinal atresia (HP:0011100)2.27788718
39Inability to walk (HP:0002540)2.27782077
40Retinal dysplasia (HP:0007973)2.27133474
41Progressive cerebellar ataxia (HP:0002073)2.23738007
42Gaze-evoked nystagmus (HP:0000640)2.22632696
43Abnormal biliary tract physiology (HP:0012439)2.22234221
44Bile duct proliferation (HP:0001408)2.22234221
45Abnormal pancreas size (HP:0012094)2.19783074
46Hyperglycinemia (HP:0002154)2.17651722
47Thyroid carcinoma (HP:0002890)2.15573621
48Polyphagia (HP:0002591)2.15210721
49Absent speech (HP:0001344)2.13766356
50Fair hair (HP:0002286)2.11482575
51Febrile seizures (HP:0002373)2.11194236
52Hypochromic microcytic anemia (HP:0004840)2.04749416
53Renal cortical cysts (HP:0000803)2.01465805
54Growth hormone deficiency (HP:0000824)2.01328301
55Renal hypoplasia (HP:0000089)1.98330200
56Protruding tongue (HP:0010808)1.98024067
57Narrow forehead (HP:0000341)1.98023196
58Cystic liver disease (HP:0006706)1.94490717
59Aqueductal stenosis (HP:0002410)1.89195268
60Tubular atrophy (HP:0000092)1.87941281
61Dynein arm defect of respiratory motile cilia (HP:0012255)1.87466521
62Absent/shortened dynein arms (HP:0200106)1.87466521
63Neoplasm of the adrenal cortex (HP:0100641)1.86546588
64Amyotrophic lateral sclerosis (HP:0007354)1.86008706
65Abnormal ciliary motility (HP:0012262)1.85747589
66Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.85544853
67Degeneration of the lateral corticospinal tracts (HP:0002314)1.85544853
68Specific learning disability (HP:0001328)1.85399206
69Impaired vibration sensation in the lower limbs (HP:0002166)1.85199168
70Hypothermia (HP:0002045)1.84878633
71Colon cancer (HP:0003003)1.82349967
72Ketoacidosis (HP:0001993)1.81174484
73Curly hair (HP:0002212)1.80560330
74Labial hypoplasia (HP:0000066)1.79054675
75Thyroid-stimulating hormone excess (HP:0002925)1.78639531
76Postaxial hand polydactyly (HP:0001162)1.78635720
77Abnormal respiratory motile cilium morphology (HP:0005938)1.77358639
78Abnormal respiratory epithelium morphology (HP:0012253)1.77358639
79Abnormal respiratory motile cilium physiology (HP:0012261)1.76424050
80Biliary tract neoplasm (HP:0100574)1.76325783
81Aplasia/Hypoplasia of the tongue (HP:0010295)1.73271642
82Morphological abnormality of the pyramidal tract (HP:0002062)1.71122294
83Inappropriate behavior (HP:0000719)1.70740651
84Bony spicule pigmentary retinopathy (HP:0007737)1.70723146
85Stomach cancer (HP:0012126)1.70476405
86Abnormality of chromosome stability (HP:0003220)1.69013757
87Hypsarrhythmia (HP:0002521)1.68537758
88Tented upper lip vermilion (HP:0010804)1.67936157
89Abnormality of vitamin B metabolism (HP:0004340)1.67790530
90Dandy-Walker malformation (HP:0001305)1.67371251
91Supernumerary spleens (HP:0009799)1.67206917
92Abnormality of the corticospinal tract (HP:0002492)1.67058657
93Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.66757263
94Pendular nystagmus (HP:0012043)1.65823319
95Dialeptic seizures (HP:0011146)1.65757591
96Thyroiditis (HP:0100646)1.64630161
97Neoplasm of the tracheobronchial system (HP:0100552)1.63709114
98Oligodactyly (hands) (HP:0001180)1.63361409
99EEG with generalized epileptiform discharges (HP:0011198)1.61894212
100Postaxial foot polydactyly (HP:0001830)1.61602285

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.11023583
2TRIM283.50524929
3MAP3K43.35133299
4CASK3.32014928
5WNK32.96799282
6BCR2.87679058
7MARK12.64061439
8MAP2K72.19400495
9DYRK31.90250153
10ERBB31.84945043
11MAPK131.82708251
12BMPR1B1.72807643
13CAMKK21.65753883
14PINK11.58559503
15MAP2K41.58525112
16DYRK21.57807043
17NUAK11.55955390
18TNIK1.51257189
19PAK31.47799591
20ACVR1B1.44281596
21CDK191.43743785
22SIK31.40905933
23MAP4K21.37636579
24MKNK21.34222756
25INSRR1.30828666
26BRD41.25593009
27SGK21.18110152
28STK38L1.17689284
29ADRBK21.11083692
30FGFR21.10741315
31TEC1.07676608
32OXSR11.06753758
33DAPK21.06135949
34EPHA31.05214856
35TAOK31.04294217
36AKT31.00517935
37YES10.98832399
38GRK10.96060640
39MINK10.92164967
40SGK2230.89932748
41SGK4940.89932748
42CSNK1G20.89247853
43ZAK0.89045080
44CAMK1D0.88266625
45MKNK10.87934769
46NLK0.86730678
47OBSCN0.86172277
48MAP3K120.84409661
49CAMK1G0.83383457
50DYRK1B0.82245756
51CSNK1G10.79833501
52TNK20.79270495
53RPS6KA40.77606871
54SRPK10.74475723
55BTK0.73984269
56DYRK1A0.73277382
57CAMK40.71694112
58STK390.71626969
59PRKCE0.70332151
60NTRK20.68902760
61MAP3K60.68330466
62CSNK1G30.67292521
63STK110.67152583
64PRKCG0.66225169
65CSNK1A1L0.65980393
66MST40.64718752
67SIK20.62592724
68BRSK20.62523089
69ERBB20.59539592
70UHMK10.59098710
71SGK10.58719641
72MAP3K70.58071394
73MARK20.54463964
74ATM0.54327407
75KSR10.53817615
76PRKAA10.53713096
77PRKCZ0.53169511
78SGK30.50424693
79PIK3CA0.50089905
80CAMK10.48925881
81ITK0.47979607
82CSNK1D0.47833068
83PRKCQ0.46347624
84LATS10.42701440
85CDC70.41931648
86PRKG10.41749327
87SYK0.41574194
88CDK50.40365945
89CSNK1E0.40352151
90PRKAA20.40063140
91PRKCB0.39932785
92PIK3CG0.39647402
93NTRK30.38923431
94FER0.38254677
95MAP3K100.38137746
96PLK20.37528135
97CDK30.37219987
98CAMKK10.36569912
99RPS6KB10.35882396
100PHKG20.33761748

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.42576548
2Nicotine addiction_Homo sapiens_hsa050333.38429765
3Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.56577293
4Phototransduction_Homo sapiens_hsa047442.55186194
5Non-homologous end-joining_Homo sapiens_hsa034502.44428931
6Protein export_Homo sapiens_hsa030602.34524287
7Butanoate metabolism_Homo sapiens_hsa006502.26440777
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.04226856
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.00237128
10Propanoate metabolism_Homo sapiens_hsa006401.93960236
11Taste transduction_Homo sapiens_hsa047421.92258334
12Regulation of autophagy_Homo sapiens_hsa041401.91341969
13Circadian rhythm_Homo sapiens_hsa047101.81164322
14GABAergic synapse_Homo sapiens_hsa047271.77596751
15Olfactory transduction_Homo sapiens_hsa047401.71676931
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.68189381
17Morphine addiction_Homo sapiens_hsa050321.65824625
18Fanconi anemia pathway_Homo sapiens_hsa034601.56482858
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.54808091
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.54588056
21Basal transcription factors_Homo sapiens_hsa030221.52389923
22Glutamatergic synapse_Homo sapiens_hsa047241.50266094
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48595882
24RNA degradation_Homo sapiens_hsa030181.44599932
25Dopaminergic synapse_Homo sapiens_hsa047281.41236677
26Serotonergic synapse_Homo sapiens_hsa047261.40161435
27Linoleic acid metabolism_Homo sapiens_hsa005911.30820004
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.27418466
29Circadian entrainment_Homo sapiens_hsa047131.27145733
30Homologous recombination_Homo sapiens_hsa034401.23824274
31Ether lipid metabolism_Homo sapiens_hsa005651.23797619
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20557363
33Dorso-ventral axis formation_Homo sapiens_hsa043201.16506753
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15270949
35Long-term depression_Homo sapiens_hsa047301.11388761
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07584148
37Type II diabetes mellitus_Homo sapiens_hsa049301.06916791
38Nitrogen metabolism_Homo sapiens_hsa009101.04483291
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04373570
40Insulin secretion_Homo sapiens_hsa049111.03534343
41Axon guidance_Homo sapiens_hsa043601.03076430
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.02467023
43Steroid biosynthesis_Homo sapiens_hsa001001.01584280
44Amphetamine addiction_Homo sapiens_hsa050310.93832141
45mRNA surveillance pathway_Homo sapiens_hsa030150.93354770
46Peroxisome_Homo sapiens_hsa041460.89824273
47Renin secretion_Homo sapiens_hsa049240.85117794
48Cocaine addiction_Homo sapiens_hsa050300.79644260
49Cholinergic synapse_Homo sapiens_hsa047250.79446755
50Retinol metabolism_Homo sapiens_hsa008300.78753891
51Caffeine metabolism_Homo sapiens_hsa002320.78751563
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78670185
53cAMP signaling pathway_Homo sapiens_hsa040240.74504548
54ABC transporters_Homo sapiens_hsa020100.68996098
55FoxO signaling pathway_Homo sapiens_hsa040680.68206054
56Collecting duct acid secretion_Homo sapiens_hsa049660.66963073
57Hedgehog signaling pathway_Homo sapiens_hsa043400.66154145
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65157520
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.63773348
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63272021
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62882311
62RNA polymerase_Homo sapiens_hsa030200.61453935
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60842386
64Choline metabolism in cancer_Homo sapiens_hsa052310.60214326
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58536609
66Chemical carcinogenesis_Homo sapiens_hsa052040.58399099
67Tryptophan metabolism_Homo sapiens_hsa003800.56783695
68Lysine degradation_Homo sapiens_hsa003100.55784672
69beta-Alanine metabolism_Homo sapiens_hsa004100.55185186
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54436184
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52676773
72Colorectal cancer_Homo sapiens_hsa052100.52625589
73Prolactin signaling pathway_Homo sapiens_hsa049170.49384430
74Starch and sucrose metabolism_Homo sapiens_hsa005000.48438780
75Oxidative phosphorylation_Homo sapiens_hsa001900.47965455
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47445237
77Salivary secretion_Homo sapiens_hsa049700.47398496
78Ras signaling pathway_Homo sapiens_hsa040140.46686305
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46502410
80Oocyte meiosis_Homo sapiens_hsa041140.45174471
81Oxytocin signaling pathway_Homo sapiens_hsa049210.44488427
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43076983
83Alcoholism_Homo sapiens_hsa050340.41171737
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.40852820
85Calcium signaling pathway_Homo sapiens_hsa040200.40832921
86Synaptic vesicle cycle_Homo sapiens_hsa047210.39923064
87Chemokine signaling pathway_Homo sapiens_hsa040620.39919619
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.38779652
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37749284
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35651718
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35575829
92Wnt signaling pathway_Homo sapiens_hsa043100.34549073
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33158152
94Parkinsons disease_Homo sapiens_hsa050120.33104213
95Long-term potentiation_Homo sapiens_hsa047200.33048163
96Fatty acid biosynthesis_Homo sapiens_hsa000610.32293562
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.31487015
98Fatty acid metabolism_Homo sapiens_hsa012120.31390409
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31335615
100Tight junction_Homo sapiens_hsa045300.31275417

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