ZNF33B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the zinc finger family of proteins. This gene shows decreased expression in cumulus cells derived from patients undergoing controlled ovarian stimulation. This gene is present in a gene cluster with several related zinc finger genes in the pericentromeric region of chromosome 10. Pseudogenes have been identified on chromosomes 7 and 10. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.00160212
2rRNA catabolic process (GO:0016075)4.30172936
3epithelial cilium movement (GO:0003351)4.19928729
4cilium or flagellum-dependent cell motility (GO:0001539)4.14544644
5cilium movement (GO:0003341)4.08467289
6axoneme assembly (GO:0035082)3.85444923
7regulation of cilium movement (GO:0003352)3.64386923
8axonemal dynein complex assembly (GO:0070286)3.63133238
9behavioral response to nicotine (GO:0035095)3.62530080
10neural tube formation (GO:0001841)3.53396052
11L-fucose catabolic process (GO:0042355)3.52189165
12fucose catabolic process (GO:0019317)3.52189165
13L-fucose metabolic process (GO:0042354)3.52189165
14centriole replication (GO:0007099)3.43990222
15intraciliary transport (GO:0042073)3.43879317
16negative regulation of cytosolic calcium ion concentration (GO:0051481)3.33762818
17ncRNA catabolic process (GO:0034661)3.21205959
18DNA double-strand break processing (GO:0000729)3.13587309
19cilium organization (GO:0044782)3.09384308
20pyrimidine nucleobase catabolic process (GO:0006208)3.09308137
21negative regulation of translation, ncRNA-mediated (GO:0040033)3.07669972
22regulation of translation, ncRNA-mediated (GO:0045974)3.07669972
23negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.07669972
24cellular ketone body metabolic process (GO:0046950)3.07300874
25indolalkylamine metabolic process (GO:0006586)3.05501126
26tryptophan catabolic process (GO:0006569)3.04829464
27indole-containing compound catabolic process (GO:0042436)3.04829464
28indolalkylamine catabolic process (GO:0046218)3.04829464
29cilium assembly (GO:0042384)3.02544010
30negative regulation of DNA-dependent DNA replication (GO:2000104)3.00971950
31respiratory chain complex IV assembly (GO:0008535)2.97874493
32nucleobase catabolic process (GO:0046113)2.90306848
33tryptophan metabolic process (GO:0006568)2.88510652
34photoreceptor cell maintenance (GO:0045494)2.87567842
35RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.87014728
36regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.84856328
37regulation of mitotic spindle checkpoint (GO:1903504)2.84856328
38regulation of DNA endoreduplication (GO:0032875)2.80387921
39cytochrome complex assembly (GO:0017004)2.79455843
40replication fork processing (GO:0031297)2.77516857
41regulation of glucokinase activity (GO:0033131)2.77173096
42regulation of hexokinase activity (GO:1903299)2.77173096
43cilium morphogenesis (GO:0060271)2.75316391
44ketone body metabolic process (GO:1902224)2.72379705
45behavioral response to ethanol (GO:0048149)2.70757652
46protein localization to cilium (GO:0061512)2.70729692
47benzene-containing compound metabolic process (GO:0042537)2.66092851
48detection of light stimulus involved in visual perception (GO:0050908)2.65092908
49detection of light stimulus involved in sensory perception (GO:0050962)2.65092908
50microtubule anchoring (GO:0034453)2.63712523
51nonmotile primary cilium assembly (GO:0035058)2.63194126
52centriole assembly (GO:0098534)2.62846766
53kidney morphogenesis (GO:0060993)2.62777695
54response to pheromone (GO:0019236)2.61687411
55reciprocal DNA recombination (GO:0035825)2.60897100
56reciprocal meiotic recombination (GO:0007131)2.60897100
57recombinational repair (GO:0000725)2.60049082
58double-strand break repair via homologous recombination (GO:0000724)2.59407388
59preassembly of GPI anchor in ER membrane (GO:0016254)2.58834629
60water-soluble vitamin biosynthetic process (GO:0042364)2.58601739
61neuronal action potential (GO:0019228)2.58288146
62regulation of microtubule-based movement (GO:0060632)2.56560001
63synapsis (GO:0007129)2.56093697
64endocrine pancreas development (GO:0031018)2.53761671
65detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.53639897
66regulation of nuclear cell cycle DNA replication (GO:0033262)2.53038216
67reflex (GO:0060004)2.51374640
68S-adenosylmethionine metabolic process (GO:0046500)2.50905078
69establishment of protein localization to Golgi (GO:0072600)2.49975889
70kynurenine metabolic process (GO:0070189)2.49126170
71sperm motility (GO:0030317)2.48482469
72adenosine metabolic process (GO:0046085)2.45790783
73regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.43566498
74inositol phosphate catabolic process (GO:0071545)2.40320902
75left/right axis specification (GO:0070986)2.39998189
76regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.39327062
77intra-S DNA damage checkpoint (GO:0031573)2.38967724
78regulation of centriole replication (GO:0046599)2.38056326
79head development (GO:0060322)2.36739554
80regulation of telomere maintenance (GO:0032204)2.36546476
81spinal cord motor neuron differentiation (GO:0021522)2.36199579
82single strand break repair (GO:0000012)2.36006659
83protein K11-linked deubiquitination (GO:0035871)2.35588736
84DNA methylation involved in gamete generation (GO:0043046)2.33530042
85piRNA metabolic process (GO:0034587)2.32721140
86organelle disassembly (GO:1903008)2.32520281
87somatic hypermutation of immunoglobulin genes (GO:0016446)2.32177279
88somatic diversification of immune receptors via somatic mutation (GO:0002566)2.32177279
89regulation of non-canonical Wnt signaling pathway (GO:2000050)2.32062203
90histone H2A acetylation (GO:0043968)2.31541700
91GPI anchor metabolic process (GO:0006505)2.31441015
92positive regulation of glycolytic process (GO:0045821)2.31119169
93seminiferous tubule development (GO:0072520)2.31116228
94polyol catabolic process (GO:0046174)2.29899215
95cellular component assembly involved in morphogenesis (GO:0010927)2.29502331
96peptidyl-histidine modification (GO:0018202)2.29482557
97branched-chain amino acid catabolic process (GO:0009083)2.28802325
98nephron tubule morphogenesis (GO:0072078)2.28358191
99nephron epithelium morphogenesis (GO:0072088)2.28358191
100ribonucleoprotein complex disassembly (GO:0032988)2.26766597

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IGF1R_20145208_ChIP-Seq_DFB_Human3.43704515
2ZNF274_21170338_ChIP-Seq_K562_Hela3.33866901
3POU3F2_20337985_ChIP-ChIP_501MEL_Human2.91893778
4VDR_22108803_ChIP-Seq_LS180_Human2.91784457
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.78386803
6FUS_26573619_Chip-Seq_HEK293_Human2.63891503
7GBX2_23144817_ChIP-Seq_PC3_Human2.55957995
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.50143112
9EWS_26573619_Chip-Seq_HEK293_Human2.31263742
10TAF15_26573619_Chip-Seq_HEK293_Human2.29965976
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.28374388
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.15313859
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.11864375
14P300_19829295_ChIP-Seq_ESCs_Human2.02905411
15ER_23166858_ChIP-Seq_MCF-7_Human2.00662075
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.00192189
17CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97101394
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.95471567
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91885341
20SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.83755793
21AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.79690264
22PIAS1_25552417_ChIP-Seq_VCAP_Human1.76135993
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72547692
24IRF1_19129219_ChIP-ChIP_H3396_Human1.68027585
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67003864
26SMAD4_21799915_ChIP-Seq_A2780_Human1.66647060
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.64005697
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.62510158
29MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.57794607
30IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.55858007
31CBP_20019798_ChIP-Seq_JUKART_Human1.55858007
32STAT3_23295773_ChIP-Seq_U87_Human1.54693136
33EZH2_22144423_ChIP-Seq_EOC_Human1.51484788
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45362802
35TCF4_23295773_ChIP-Seq_U87_Human1.44090179
36* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43999886
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42883938
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.42834788
39NFE2_27457419_Chip-Seq_LIVER_Mouse1.42596126
40AR_25329375_ChIP-Seq_VCAP_Human1.40699138
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40458498
42KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.40254816
43EST1_17652178_ChIP-ChIP_JURKAT_Human1.40123875
44BCAT_22108803_ChIP-Seq_LS180_Human1.39826321
45TP53_22573176_ChIP-Seq_HFKS_Human1.39696238
46EZH2_27294783_Chip-Seq_NPCs_Mouse1.38924868
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38738509
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38307168
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.37877254
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.37333031
51ELK1_19687146_ChIP-ChIP_HELA_Human1.36579052
52TCF4_22108803_ChIP-Seq_LS180_Human1.34192136
53TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33622991
54GABP_17652178_ChIP-ChIP_JURKAT_Human1.33064213
55PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31601927
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.31033487
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30722996
58NANOG_18555785_Chip-Seq_ESCs_Mouse1.28952453
59NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28324869
60MYC_18940864_ChIP-ChIP_HL60_Human1.28203557
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27962480
62RUNX2_22187159_ChIP-Seq_PCA_Human1.27249758
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26771727
64PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.26047395
65NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24686918
66EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24165253
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24092840
68FOXA1_25329375_ChIP-Seq_VCAP_Human1.22225311
69FOXA1_27270436_Chip-Seq_PROSTATE_Human1.22225311
70POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21995468
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21995468
72VDR_23849224_ChIP-Seq_CD4+_Human1.21017224
73P53_22387025_ChIP-Seq_ESCs_Mouse1.20146112
74FOXA1_21572438_ChIP-Seq_LNCaP_Human1.19916467
75CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19885371
76GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19677502
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18797470
78RNF2_27304074_Chip-Seq_NSC_Mouse1.17289246
79* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17218400
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15730692
81SOX2_19829295_ChIP-Seq_ESCs_Human1.15021207
82NANOG_19829295_ChIP-Seq_ESCs_Human1.15021207
83RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13737715
84TAL1_26923725_Chip-Seq_HPCs_Mouse1.13472732
85REST_21632747_ChIP-Seq_MESCs_Mouse1.13446361
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.13308002
87TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10611473
88E2F1_18555785_Chip-Seq_ESCs_Mouse1.09095612
89FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08721311
90CRX_20693478_ChIP-Seq_RETINA_Mouse1.08544673
91RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07352660
92SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05667369
93P300_18555785_Chip-Seq_ESCs_Mouse1.05504771
94FLI1_21867929_ChIP-Seq_TH2_Mouse1.05115607
95STAT3_18555785_Chip-Seq_ESCs_Mouse1.04736181
96CMYC_18555785_Chip-Seq_ESCs_Mouse1.04680132
97ETV1_20927104_ChIP-Seq_GIST48_Human1.04577557
98AR_20517297_ChIP-Seq_VCAP_Human1.02306534
99AR_21572438_ChIP-Seq_LNCaP_Human1.01903687
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01819770

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting3.85914515
2MP0008877_abnormal_DNA_methylation3.66559523
3MP0002102_abnormal_ear_morphology2.98741681
4MP0008057_abnormal_DNA_replication2.68286087
5MP0005645_abnormal_hypothalamus_physiol2.37977662
6MP0003122_maternal_imprinting2.26941155
7MP0003121_genomic_imprinting2.20977406
8MP0003195_calcinosis2.19338946
9MP0001986_abnormal_taste_sensitivity2.17301079
10MP0001188_hyperpigmentation1.98984755
11MP0004043_abnormal_pH_regulation1.90813615
12MP0005084_abnormal_gallbladder_morpholo1.82668273
13MP0002822_catalepsy1.79890397
14MP0000569_abnormal_digit_pigmentation1.77678495
15MP0001984_abnormal_olfaction1.72297832
16MP0002638_abnormal_pupillary_reflex1.71360877
17MP0005551_abnormal_eye_electrophysiolog1.69520490
18MP0006072_abnormal_retinal_apoptosis1.69150802
19MP0006276_abnormal_autonomic_nervous1.67096933
20MP0008058_abnormal_DNA_repair1.66814128
21MP0002909_abnormal_adrenal_gland1.65468310
22MP0008872_abnormal_physiological_respon1.58092511
23MP0008995_early_reproductive_senescence1.56251960
24MP0001968_abnormal_touch/_nociception1.52916538
25MP0002876_abnormal_thyroid_physiology1.47435681
26MP0004885_abnormal_endolymph1.44323825
27MP0002009_preneoplasia1.43078971
28MP0000631_abnormal_neuroendocrine_gland1.41176003
29MP0002837_dystrophic_cardiac_calcinosis1.39874976
30MP0004133_heterotaxia1.39639890
31MP0004147_increased_porphyrin_level1.37461755
32MP0004142_abnormal_muscle_tone1.36205261
33MP0003880_abnormal_central_pattern1.35045289
34MP0005220_abnormal_exocrine_pancreas1.34341063
35MP0003890_abnormal_embryonic-extraembry1.34246616
36MP0005075_abnormal_melanosome_morpholog1.34198583
37MP0006292_abnormal_olfactory_placode1.33250680
38MP0005253_abnormal_eye_physiology1.32348642
39MP0000427_abnormal_hair_cycle1.30913437
40MP0002928_abnormal_bile_duct1.29818687
41MP0002163_abnormal_gland_morphology1.26333744
42MP0002272_abnormal_nervous_system1.24065722
43MP0008789_abnormal_olfactory_epithelium1.19660801
44MP0003011_delayed_dark_adaptation1.19500114
45MP0005646_abnormal_pituitary_gland1.18488875
46MP0008875_abnormal_xenobiotic_pharmacok1.17991428
47MP0001485_abnormal_pinna_reflex1.16981877
48MP0001529_abnormal_vocalization1.16719301
49MP0002557_abnormal_social/conspecific_i1.14260128
50MP0001486_abnormal_startle_reflex1.10075777
51MP0010386_abnormal_urinary_bladder1.08945754
52MP0009046_muscle_twitch1.08931837
53MP0002693_abnormal_pancreas_physiology1.08021478
54MP0009745_abnormal_behavioral_response1.07456839
55MP0002735_abnormal_chemical_nociception1.06656891
56MP0002160_abnormal_reproductive_system1.06119232
57MP0000383_abnormal_hair_follicle1.06006927
58MP0005379_endocrine/exocrine_gland_phen1.05452504
59MP0001293_anophthalmia1.04035848
60MP0002938_white_spotting1.02356764
61MP0005367_renal/urinary_system_phenotyp1.01454223
62MP0000516_abnormal_urinary_system1.01454223
63MP0005085_abnormal_gallbladder_physiolo1.01159770
64MP0009697_abnormal_copulation1.00717270
65MP0003698_abnormal_male_reproductive1.00063630
66MP0004924_abnormal_behavior0.97274795
67MP0005386_behavior/neurological_phenoty0.97274795
68MP0003718_maternal_effect0.97124177
69MP0001666_abnormal_nutrient_absorption0.95344474
70MP0005389_reproductive_system_phenotype0.94852944
71MP0001501_abnormal_sleep_pattern0.93091380
72MP0005394_taste/olfaction_phenotype0.92438140
73MP0005499_abnormal_olfactory_system0.92438140
74MP0002138_abnormal_hepatobiliary_system0.92168516
75MP0002736_abnormal_nociception_after0.91010192
76MP0001944_abnormal_pancreas_morphology0.90840700
77MP0001929_abnormal_gametogenesis0.89274530
78MP0009780_abnormal_chondrocyte_physiolo0.85805354
79MP0003937_abnormal_limbs/digits/tail_de0.85495815
80MP0004145_abnormal_muscle_electrophysio0.85439018
81MP0005377_hearing/vestibular/ear_phenot0.82562670
82MP0003878_abnormal_ear_physiology0.82562670
83MP0001919_abnormal_reproductive_system0.81547407
84MP0002184_abnormal_innervation0.80917991
85MP0001970_abnormal_pain_threshold0.80302776
86MP0002277_abnormal_respiratory_mucosa0.79847532
87MP0003119_abnormal_digestive_system0.79718776
88MP0003567_abnormal_fetal_cardiomyocyte0.78775900
89MP0006035_abnormal_mitochondrial_morpho0.78749636
90MP0002572_abnormal_emotion/affect_behav0.78467438
91MP0002733_abnormal_thermal_nociception0.78403729
92MP0001764_abnormal_homeostasis0.77895226
93MP0000653_abnormal_sex_gland0.77690042
94MP0003866_abnormal_defecation0.76576563
95MP0001756_abnormal_urination0.74445646
96MP0001145_abnormal_male_reproductive0.74298430
97MP0005174_abnormal_tail_pigmentation0.74239464
98MP0003635_abnormal_synaptic_transmissio0.72428909
99MP0002210_abnormal_sex_determination0.71939549
100MP0003786_premature_aging0.71665646

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.07742806
2Pancreatic fibrosis (HP:0100732)3.84381055
3Abnormality of the renal cortex (HP:0011035)3.65102092
4Nephronophthisis (HP:0000090)3.56097194
5True hermaphroditism (HP:0010459)3.46469616
6Chronic hepatic failure (HP:0100626)3.37851068
7Abnormality of the renal medulla (HP:0100957)3.37751085
8Molar tooth sign on MRI (HP:0002419)3.22546328
9Abnormality of midbrain morphology (HP:0002418)3.22546328
10Absent/shortened dynein arms (HP:0200106)3.10618003
11Dynein arm defect of respiratory motile cilia (HP:0012255)3.10618003
12Abnormal respiratory motile cilium morphology (HP:0005938)3.05312637
13Abnormal respiratory epithelium morphology (HP:0012253)3.05312637
14Medial flaring of the eyebrow (HP:0010747)2.93911192
15Tubulointerstitial nephritis (HP:0001970)2.87019559
16Renal cortical cysts (HP:0000803)2.82798941
17Hypothermia (HP:0002045)2.77214607
18Abnormal ciliary motility (HP:0012262)2.74748006
19Cystic liver disease (HP:0006706)2.73531998
20Abnormal respiratory motile cilium physiology (HP:0012261)2.54369628
21Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.53395582
22Colon cancer (HP:0003003)2.50192808
23Tubular atrophy (HP:0000092)2.49638183
24Abnormal biliary tract physiology (HP:0012439)2.49500291
25Bile duct proliferation (HP:0001408)2.49500291
26Volvulus (HP:0002580)2.43643407
27Hyperventilation (HP:0002883)2.41625508
28Nephrogenic diabetes insipidus (HP:0009806)2.38532535
29Thyroid-stimulating hormone excess (HP:0002925)2.33636359
30Intestinal atresia (HP:0011100)2.33353164
31Abnormality of the labia minora (HP:0012880)2.31316129
32Rhinitis (HP:0012384)2.29878605
33Ketoacidosis (HP:0001993)2.28485278
34Gaze-evoked nystagmus (HP:0000640)2.27269221
35Gait imbalance (HP:0002141)2.26608811
36Abnormal drinking behavior (HP:0030082)2.18514379
37Polydipsia (HP:0001959)2.18514379
38Congenital stationary night blindness (HP:0007642)2.17822634
39Congenital primary aphakia (HP:0007707)2.15898246
40Neoplasm of the adrenal cortex (HP:0100641)2.15890791
41Abolished electroretinogram (ERG) (HP:0000550)2.15039593
42Occipital encephalocele (HP:0002085)2.12784161
43Type II lissencephaly (HP:0007260)2.10960022
44Ketosis (HP:0001946)2.08667957
45Hyperinsulinemic hypoglycemia (HP:0000825)2.08197105
46Postaxial foot polydactyly (HP:0001830)2.07965601
47Congenital hepatic fibrosis (HP:0002612)2.06583497
48Genital tract atresia (HP:0001827)2.05681236
49Broad-based gait (HP:0002136)2.04183542
50Male pseudohermaphroditism (HP:0000037)2.03713940
51Chronic bronchitis (HP:0004469)2.03267722
52Vaginal atresia (HP:0000148)2.00535107
53Lissencephaly (HP:0001339)1.98388388
54Furrowed tongue (HP:0000221)1.97333353
55Stomach cancer (HP:0012126)1.96397111
56Abnormal rod and cone electroretinograms (HP:0008323)1.96055942
57Enlarged kidneys (HP:0000105)1.95669834
58Pendular nystagmus (HP:0012043)1.95352026
59Sclerocornea (HP:0000647)1.94425757
60Drooling (HP:0002307)1.94245526
61Hepatoblastoma (HP:0002884)1.94175290
62Abnormality of endocrine pancreas physiology (HP:0012093)1.93284399
63Abnormality of the pancreatic islet cells (HP:0006476)1.93284399
64Abnormal pancreas size (HP:0012094)1.93282383
65Hypoglycemic seizures (HP:0002173)1.91816935
66Febrile seizures (HP:0002373)1.90862173
67Tubulointerstitial abnormality (HP:0001969)1.87565378
68Dyskinesia (HP:0100660)1.86456556
69Progressive inability to walk (HP:0002505)1.85542548
70Aplasia/Hypoplasia of the tongue (HP:0010295)1.85290073
71Thyroiditis (HP:0100646)1.82374681
72Bronchiectasis (HP:0002110)1.82359130
733-Methylglutaconic aciduria (HP:0003535)1.81187027
74Hip dysplasia (HP:0001385)1.80176801
75Hypoglycemic coma (HP:0001325)1.80175869
76Polyuria (HP:0000103)1.79418023
77Methylmalonic acidemia (HP:0002912)1.78306343
78Excessive salivation (HP:0003781)1.76872903
79Postaxial hand polydactyly (HP:0001162)1.75911968
80Attenuation of retinal blood vessels (HP:0007843)1.75159732
81Anencephaly (HP:0002323)1.74116525
82Bony spicule pigmentary retinopathy (HP:0007737)1.73823085
83Aplasia/Hypoplasia of the spleen (HP:0010451)1.72964550
84Abnormality of chromosome stability (HP:0003220)1.70829756
85Sloping forehead (HP:0000340)1.70303988
86Absent rod-and cone-mediated responses on ERG (HP:0007688)1.69334438
87Protruding tongue (HP:0010808)1.68573069
88Asplenia (HP:0001746)1.67163837
89Poor coordination (HP:0002370)1.66941072
90Growth hormone deficiency (HP:0000824)1.65332136
91Agitation (HP:0000713)1.64065311
92Polyphagia (HP:0002591)1.63885820
93Gonadotropin excess (HP:0000837)1.63341622
94Decreased central vision (HP:0007663)1.62081511
95Inability to walk (HP:0002540)1.61155249
96Abnormality of macular pigmentation (HP:0008002)1.59752181
97Fair hair (HP:0002286)1.57051968
98Dandy-Walker malformation (HP:0001305)1.56797678
99Supernumerary spleens (HP:0009799)1.56541493
100Oligodactyly (hands) (HP:0001180)1.55966857

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.08398352
2MAP4K23.01765097
3MAP3K42.92201749
4WNK32.87802135
5CASK2.55879686
6BMPR1B2.54316798
7NUAK12.43812943
8ZAK2.14367179
9WNK41.98296364
10AKT31.88510743
11TNIK1.86171354
12BCR1.86030171
13INSRR1.81925132
14MAPK131.79709108
15PINK11.75948371
16STK391.69717812
17TAOK31.65464390
18SRPK11.62258425
19OXSR11.59790929
20TRIM281.58480093
21ERBB31.56818001
22MST41.56792486
23GRK11.51144613
24ADRBK21.51031017
25ACVR1B1.42712125
26FGFR21.38345663
27MKNK21.35327382
28MKNK11.34334081
29MAP2K71.31684970
30TEC1.30666401
31CDK191.11852201
32TXK1.11291711
33PLK41.08114481
34PIK3CA1.07818904
35CSNK1G11.05114126
36PAK31.01624903
37PASK0.98019056
38TNK20.96937279
39DYRK20.95298911
40DYRK30.91772151
41NLK0.89987578
42DAPK20.89221170
43PRKCE0.88817205
44VRK10.87259280
45CSNK1G20.86756319
46STK38L0.81841380
47STK30.80292255
48CSNK1G30.79555637
49CAMKK20.79186451
50PLK20.75596163
51MAP2K40.72667203
52PLK30.72580094
53MINK10.72226591
54BRSK20.69753450
55CSNK1A1L0.69299129
56SGK20.67823458
57ATM0.66290020
58ATR0.63425361
59CDC70.61542202
60PHKG20.60990042
61PHKG10.60990042
62BCKDK0.58829041
63BTK0.56865567
64CSNK1E0.55349475
65DYRK1A0.54910730
66CDK30.54754997
67RPS6KA40.54557109
68ITK0.54405908
69EPHA40.52227884
70MARK10.51079167
71TLK10.49776285
72CSNK1D0.49567952
73SGK4940.47460009
74SGK2230.47460009
75PRKCG0.46346425
76PRKCQ0.45494204
77PRKAA10.45382813
78CAMK1G0.44885687
79TGFBR10.44870161
80SIK20.44862188
81NEK20.44745961
82WNK10.44670912
83EIF2AK30.43808706
84MAPK150.43264286
85MAP2K60.42496315
86STK110.42188695
87TAF10.41925349
88MAP3K90.40405229
89SYK0.39584742
90PLK10.38513635
91NTRK30.37089259
92SGK10.36688989
93PNCK0.36118259
94PRKDC0.35186923
95TIE10.33942125
96PRKACA0.33762410
97CSNK1A10.33705810
98PRKAA20.32842159
99LATS10.32011648
100RPS6KA50.31755383

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.97187154
2Butanoate metabolism_Homo sapiens_hsa006502.74999774
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.74025583
4Phototransduction_Homo sapiens_hsa047442.37226193
5Non-homologous end-joining_Homo sapiens_hsa034502.36129150
6Nicotine addiction_Homo sapiens_hsa050332.28383555
7Propanoate metabolism_Homo sapiens_hsa006402.18331425
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.13766359
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.12636355
10Linoleic acid metabolism_Homo sapiens_hsa005912.05616925
11Protein export_Homo sapiens_hsa030601.96500290
12Fanconi anemia pathway_Homo sapiens_hsa034601.91303989
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.85403486
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.85213435
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.79912722
16Selenocompound metabolism_Homo sapiens_hsa004501.77988962
17Basal transcription factors_Homo sapiens_hsa030221.69031226
18Taste transduction_Homo sapiens_hsa047421.67227546
19Homologous recombination_Homo sapiens_hsa034401.67135991
20Ether lipid metabolism_Homo sapiens_hsa005651.64941424
21Tryptophan metabolism_Homo sapiens_hsa003801.59642139
22Peroxisome_Homo sapiens_hsa041461.54586792
23RNA degradation_Homo sapiens_hsa030181.52563205
24Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.49763332
25RNA polymerase_Homo sapiens_hsa030201.48562900
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.46806777
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.44070409
28Retinol metabolism_Homo sapiens_hsa008301.39324992
29Caffeine metabolism_Homo sapiens_hsa002321.38698194
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.35036442
31Chemical carcinogenesis_Homo sapiens_hsa052041.32526263
32Olfactory transduction_Homo sapiens_hsa047401.31685497
33Nitrogen metabolism_Homo sapiens_hsa009101.27400861
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.25487532
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.20929853
36Oxidative phosphorylation_Homo sapiens_hsa001901.17345650
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.16935395
38One carbon pool by folate_Homo sapiens_hsa006701.12208997
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.11173751
40Insulin secretion_Homo sapiens_hsa049111.10843612
41Regulation of autophagy_Homo sapiens_hsa041401.08541912
42Fat digestion and absorption_Homo sapiens_hsa049751.04224353
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.03952567
44Serotonergic synapse_Homo sapiens_hsa047261.03754634
45Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.03372303
46Morphine addiction_Homo sapiens_hsa050321.01724655
47GABAergic synapse_Homo sapiens_hsa047270.99068389
48ABC transporters_Homo sapiens_hsa020100.95408733
49beta-Alanine metabolism_Homo sapiens_hsa004100.95021092
50Arachidonic acid metabolism_Homo sapiens_hsa005900.93058013
51Fatty acid degradation_Homo sapiens_hsa000710.87205061
52Glutamatergic synapse_Homo sapiens_hsa047240.86856408
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.86153847
54Type I diabetes mellitus_Homo sapiens_hsa049400.85184951
55Circadian entrainment_Homo sapiens_hsa047130.84301847
56Parkinsons disease_Homo sapiens_hsa050120.84127139
57RNA transport_Homo sapiens_hsa030130.83178450
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82741144
59Huntingtons disease_Homo sapiens_hsa050160.80457755
60Long-term depression_Homo sapiens_hsa047300.78712041
61Steroid biosynthesis_Homo sapiens_hsa001000.78396829
62Pancreatic secretion_Homo sapiens_hsa049720.78206939
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78024792
64Dopaminergic synapse_Homo sapiens_hsa047280.75542523
65Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.74627064
66Mismatch repair_Homo sapiens_hsa034300.71417669
67Fatty acid metabolism_Homo sapiens_hsa012120.71217780
68Purine metabolism_Homo sapiens_hsa002300.68749456
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64566496
70Histidine metabolism_Homo sapiens_hsa003400.64338348
71Amphetamine addiction_Homo sapiens_hsa050310.63095542
72Salivary secretion_Homo sapiens_hsa049700.61631582
73Vitamin digestion and absorption_Homo sapiens_hsa049770.60351017
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58058401
75Glycerolipid metabolism_Homo sapiens_hsa005610.57474622
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57448783
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.57174046
78Type II diabetes mellitus_Homo sapiens_hsa049300.55580052
79Intestinal immune network for IgA production_Homo sapiens_hsa046720.54137936
80Metabolic pathways_Homo sapiens_hsa011000.53943393
81Starch and sucrose metabolism_Homo sapiens_hsa005000.53184440
82Circadian rhythm_Homo sapiens_hsa047100.52852819
83mRNA surveillance pathway_Homo sapiens_hsa030150.50541715
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.50116525
85Fatty acid biosynthesis_Homo sapiens_hsa000610.49984183
86Primary immunodeficiency_Homo sapiens_hsa053400.47424967
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46326311
88Lysine degradation_Homo sapiens_hsa003100.45190103
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44705204
90Ovarian steroidogenesis_Homo sapiens_hsa049130.44113106
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44109277
92Fatty acid elongation_Homo sapiens_hsa000620.40548328
93Cocaine addiction_Homo sapiens_hsa050300.39683465
94Cholinergic synapse_Homo sapiens_hsa047250.38759992
95Spliceosome_Homo sapiens_hsa030400.38754688
96Alzheimers disease_Homo sapiens_hsa050100.37492857
97Renin secretion_Homo sapiens_hsa049240.36915834
98Pyrimidine metabolism_Homo sapiens_hsa002400.34777176
99Cardiac muscle contraction_Homo sapiens_hsa042600.32988972
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31259828

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