ZNF33BP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1interkinetic nuclear migration (GO:0022027)6.04778284
2regulation of hexokinase activity (GO:1903299)5.86013118
3regulation of glucokinase activity (GO:0033131)5.86013118
4regulation of protein polyubiquitination (GO:1902914)5.83380022
5relaxation of smooth muscle (GO:0044557)5.69634517
6regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022355.67857069
7response to nitrosative stress (GO:0051409)4.82550390
8chemosensory behavior (GO:0007635)4.79851745
9protein K6-linked ubiquitination (GO:0085020)4.79775320
10intra-S DNA damage checkpoint (GO:0031573)4.75169377
11positive regulation of mitochondrial fission (GO:0090141)4.53407510
12SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)4.51595323
13L-fucose catabolic process (GO:0042355)4.51540020
14fucose catabolic process (GO:0019317)4.51540020
15L-fucose metabolic process (GO:0042354)4.51540020
16phenylpropanoid metabolic process (GO:0009698)4.51466666
17C4-dicarboxylate transport (GO:0015740)4.49128923
18startle response (GO:0001964)4.46594242
19smooth muscle tissue development (GO:0048745)4.42033196
20urinary tract smooth muscle contraction (GO:0014848)4.36999295
21negative regulation of protein localization to cell surface (GO:2000009)4.12211751
22dopamine transport (GO:0015872)3.93685918
23mitotic sister chromatid cohesion (GO:0007064)3.93309650
24mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.86509421
25positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.86509421
26kinetochore assembly (GO:0051382)3.78460351
27cell morphogenesis involved in neuron differentiation (GO:0048667)3.76203601
28regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.74835332
29xenobiotic catabolic process (GO:0042178)3.60328880
30neurotransmitter uptake (GO:0001504)3.59834864
31nucleus localization (GO:0051647)3.56013332
32peristalsis (GO:0030432)3.55502080
33regulation of mitochondrial translation (GO:0070129)3.54702962
34vitamin transmembrane transport (GO:0035461)3.51414901
35regulation of oxidative stress-induced neuron death (GO:1903203)3.49624482
36catecholamine transport (GO:0051937)3.42093201
37establishment of protein localization to Golgi (GO:0072600)3.34798244
38protein targeting to lysosome (GO:0006622)3.32195109
39establishment of protein localization to vacuole (GO:0072666)3.32195109
40protein targeting to vacuole (GO:0006623)3.32195109
41relaxation of muscle (GO:0090075)3.30119419
42kinetochore organization (GO:0051383)3.28911694
43regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.24025265
44regulation of endothelial cell chemotaxis (GO:2001026)3.16230164
45norepinephrine metabolic process (GO:0042415)3.12624614
46response to manganese ion (GO:0010042)3.08927544
47translesion synthesis (GO:0019985)3.08250883
48lipid translocation (GO:0034204)3.07419802
49phospholipid translocation (GO:0045332)3.07419802
50positive regulation of actin filament depolymerization (GO:0030836)3.06890601
51negative regulation of actin filament bundle assembly (GO:0032232)3.05087204
52negative regulation of smooth muscle cell differentiation (GO:0051151)3.03424816
53regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.01083543
54negative regulation of smooth muscle contraction (GO:0045986)3.00937420
55left/right axis specification (GO:0070986)3.00443551
56early endosome to late endosome transport (GO:0045022)2.99129136
57detection of light stimulus involved in sensory perception (GO:0050962)2.98958381
58detection of light stimulus involved in visual perception (GO:0050908)2.98958381
59Sertoli cell development (GO:0060009)2.88084520
60positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.87619225
61regulation of mitochondrial fission (GO:0090140)2.87337436
62somite development (GO:0061053)2.86652753
63zinc ion homeostasis (GO:0055069)2.85603623
64platelet dense granule organization (GO:0060155)2.85389933
65behavioral response to ethanol (GO:0048149)2.83763403
66histone H3-K9 methylation (GO:0051567)2.81005578
67regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.78632479
68cell proliferation in forebrain (GO:0021846)2.78050098
69negative regulation of interleukin-17 production (GO:0032700)2.73431751
70neuromuscular synaptic transmission (GO:0007274)2.72246044
71nitric oxide mediated signal transduction (GO:0007263)2.72233149
72neuronal stem cell maintenance (GO:0097150)2.70888627
73regulation of transforming growth factor beta2 production (GO:0032909)2.70822687
74protein localization to lysosome (GO:0061462)2.69431014
75protein localization to vacuole (GO:0072665)2.69431014
76regulation of type B pancreatic cell apoptotic process (GO:2000674)2.68513165
77cGMP-mediated signaling (GO:0019934)2.65672213
78outer ear morphogenesis (GO:0042473)2.64801006
79macroautophagy (GO:0016236)2.64697658
80positive regulation of histone methylation (GO:0031062)2.64620769
81regulation of skeletal muscle contraction (GO:0014819)2.64361978
82ubiquinone biosynthetic process (GO:0006744)2.62799740
83regulation of protein glycosylation (GO:0060049)2.62480390
84Rac protein signal transduction (GO:0016601)2.61530477
85regulation of actin nucleation (GO:0051125)2.58874247
86regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.58669651
87protein targeting to Golgi (GO:0000042)2.57858385
88ionotropic glutamate receptor signaling pathway (GO:0035235)2.56780318
89oligosaccharide catabolic process (GO:0009313)2.56623981
90inositol metabolic process (GO:0006020)2.55745985
91aggressive behavior (GO:0002118)2.55180539
92negative regulation of muscle contraction (GO:0045932)2.54566645
93positive regulation of cation channel activity (GO:2001259)2.53943229
94branching involved in prostate gland morphogenesis (GO:0060442)2.52624708
95ventricular system development (GO:0021591)2.50541779
96pseudouridine synthesis (GO:0001522)2.50009861
97phasic smooth muscle contraction (GO:0014821)2.48702826
98protein polyglutamylation (GO:0018095)2.45986624
99ubiquinone metabolic process (GO:0006743)2.44742995
100monoubiquitinated protein deubiquitination (GO:0035520)2.44699192

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human3.63031521
2GBX2_23144817_ChIP-Seq_PC3_Human3.56450817
3STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.48192732
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.31658800
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.30718997
6IGF1R_20145208_ChIP-Seq_DFB_Human3.12230887
7ZNF274_21170338_ChIP-Seq_K562_Hela3.12224961
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.84613668
9EZH2_22144423_ChIP-Seq_EOC_Human2.73151809
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.68058069
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.54100200
12EWS_26573619_Chip-Seq_HEK293_Human2.48653718
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.46893416
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.46681252
15AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.42961896
16P300_19829295_ChIP-Seq_ESCs_Human2.17197946
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.16393317
18PIAS1_25552417_ChIP-Seq_VCAP_Human2.04450746
19SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.99462756
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.96987303
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95907861
22FUS_26573619_Chip-Seq_HEK293_Human1.93431578
23SMAD4_21799915_ChIP-Seq_A2780_Human1.92538754
24STAT3_23295773_ChIP-Seq_U87_Human1.85244862
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.84175614
26SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.80921695
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.80476492
28VDR_22108803_ChIP-Seq_LS180_Human1.77855543
29TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.75115813
30CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.70991556
31ER_23166858_ChIP-Seq_MCF-7_Human1.66664653
32IRF1_19129219_ChIP-ChIP_H3396_Human1.64317364
33RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.62613643
34OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59981153
35SMAD3_21741376_ChIP-Seq_EPCs_Human1.57928749
36NR3C1_21868756_ChIP-Seq_MCF10A_Human1.57569878
37FOXM1_26456572_ChIP-Seq_MCF-7_Human1.57306252
38NRF2_20460467_ChIP-Seq_MEFs_Mouse1.56952935
39NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.56952935
40EZH2_27294783_Chip-Seq_NPCs_Mouse1.56246781
41BCAT_22108803_ChIP-Seq_LS180_Human1.51538333
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.51236133
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.51217895
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50699142
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49725293
46PRDM14_20953172_ChIP-Seq_ESCs_Human1.49568335
47TCF4_23295773_ChIP-Seq_U87_Human1.45629878
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45478582
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.45478582
50CBP_20019798_ChIP-Seq_JUKART_Human1.45288056
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45288056
52TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.43124753
53EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.42265875
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.41935724
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41546714
56CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.41523379
57RNF2_27304074_Chip-Seq_NSC_Mouse1.37515911
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37001753
59NANOG_18555785_Chip-Seq_ESCs_Mouse1.35030987
60KLF5_20875108_ChIP-Seq_MESCs_Mouse1.33565940
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.33088762
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.32444511
63RUNX2_22187159_ChIP-Seq_PCA_Human1.32345864
64AR_25329375_ChIP-Seq_VCAP_Human1.31190452
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30687750
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.28758657
67TCF4_22108803_ChIP-Seq_LS180_Human1.28605898
68CRX_20693478_ChIP-Seq_RETINA_Mouse1.27776566
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.26536377
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25417268
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.22126593
72EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21357504
73CTNNB1_20460455_ChIP-Seq_HCT116_Human1.19711135
74FLI1_21867929_ChIP-Seq_TH2_Mouse1.18288582
75TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.17858278
76TP53_18474530_ChIP-ChIP_U2OS_Human1.17082261
77SMAD4_21741376_ChIP-Seq_EPCs_Human1.16541532
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15455717
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14824348
80NFE2_27457419_Chip-Seq_LIVER_Mouse1.14772937
81CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13456120
82CDX2_22108803_ChIP-Seq_LS180_Human1.12978534
83SOX2_21211035_ChIP-Seq_LN229_Gbm1.10694301
84TP53_16413492_ChIP-PET_HCT116_Human1.08980457
85P53_22387025_ChIP-Seq_ESCs_Mouse1.08877829
86TBL1_22424771_ChIP-Seq_293T_Human1.08220622
87KDM2B_26808549_Chip-Seq_REH_Human1.07252578
88AR_21572438_ChIP-Seq_LNCaP_Human1.07221994
89OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06400474
90PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05324777
91KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04869446
92TAF15_26573619_Chip-Seq_HEK293_Human1.02471821
93SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01021562
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99999636
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99886944
96SOX2_19829295_ChIP-Seq_ESCs_Human0.99674976
97NANOG_19829295_ChIP-Seq_ESCs_Human0.99674976
98E2F1_18555785_Chip-Seq_ESCs_Mouse0.99126217
99P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98562224
100WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95899849

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.01709378
2MP0005174_abnormal_tail_pigmentation4.07465959
3MP0002163_abnormal_gland_morphology3.03420983
4MP0003195_calcinosis2.73749357
5MP0009697_abnormal_copulation2.66770985
6MP0005379_endocrine/exocrine_gland_phen2.63490857
7MP0006072_abnormal_retinal_apoptosis2.62358476
8MP0004885_abnormal_endolymph2.56870406
9MP0004147_increased_porphyrin_level2.51655800
10MP0008995_early_reproductive_senescence2.35957001
11MP0001485_abnormal_pinna_reflex2.09501001
12MP0005646_abnormal_pituitary_gland2.09103259
13MP0010368_abnormal_lymphatic_system2.05689935
14MP0005551_abnormal_eye_electrophysiolog1.94677908
15MP0000015_abnormal_ear_pigmentation1.94149047
16MP0003879_abnormal_hair_cell1.93342488
17MP0008057_abnormal_DNA_replication1.86019885
18MP0003045_fibrosis1.82732448
19MP0009046_muscle_twitch1.80990038
20MP0003567_abnormal_fetal_cardiomyocyte1.80159021
21MP0003943_abnormal_hepatobiliary_system1.79787144
22MP0006292_abnormal_olfactory_placode1.78712068
23MP0004084_abnormal_cardiac_muscle1.72872954
24MP0008877_abnormal_DNA_methylation1.68236145
25MP0009379_abnormal_foot_pigmentation1.64346797
26MP0001501_abnormal_sleep_pattern1.63853412
27MP0001486_abnormal_startle_reflex1.61952993
28MP0003880_abnormal_central_pattern1.60527153
29MP0002095_abnormal_skin_pigmentation1.56290210
30MP0003787_abnormal_imprinting1.55106195
31MP0005253_abnormal_eye_physiology1.55065512
32MP0002272_abnormal_nervous_system1.54289663
33MP0001502_abnormal_circadian_rhythm1.50199358
34MP0003283_abnormal_digestive_organ1.48611150
35MP0003646_muscle_fatigue1.46044880
36MP0001968_abnormal_touch/_nociception1.44696772
37MP0000566_synostosis1.43014787
38MP0002233_abnormal_nose_morphology1.41277617
39MP0001963_abnormal_hearing_physiology1.40227125
40MP0004036_abnormal_muscle_relaxation1.38562324
41MP0000026_abnormal_inner_ear1.38411770
42MP0001664_abnormal_digestion1.32655174
43MP0002736_abnormal_nociception_after1.30728883
44MP0004145_abnormal_muscle_electrophysio1.29057003
45MP0008058_abnormal_DNA_repair1.28695067
46MP0004043_abnormal_pH_regulation1.24557514
47MP0002735_abnormal_chemical_nociception1.22476203
48MP0005620_abnormal_muscle_contractility1.22299999
49MP0000462_abnormal_digestive_system1.21711738
50MP0002106_abnormal_muscle_physiology1.19640535
51MP0002229_neurodegeneration1.14698483
52MP0005220_abnormal_exocrine_pancreas1.10385174
53MP0005369_muscle_phenotype1.08404372
54MP0005332_abnormal_amino_acid1.08339393
55MP0002572_abnormal_emotion/affect_behav1.04954038
56MP0000631_abnormal_neuroendocrine_gland1.04532308
57MP0004130_abnormal_muscle_cell1.03499282
58MP0005595_abnormal_vascular_smooth1.02500154
59MP0003011_delayed_dark_adaptation1.01978994
60MP0001293_anophthalmia1.01709007
61MP0000751_myopathy0.98765671
62MP0001529_abnormal_vocalization0.97949904
63MP0002108_abnormal_muscle_morphology0.96362891
64MP0005386_behavior/neurological_phenoty0.95005548
65MP0004924_abnormal_behavior0.95005548
66MP0010386_abnormal_urinary_bladder0.93485460
67MP0003755_abnormal_palate_morphology0.93049527
68MP0008569_lethality_at_weaning0.92758497
69MP0002653_abnormal_ependyma_morphology0.92742900
70MP0000749_muscle_degeneration0.91950285
71MP0003950_abnormal_plasma_membrane0.91544663
72MP0003119_abnormal_digestive_system0.90093337
73MP0000049_abnormal_middle_ear0.89795306
74MP0000013_abnormal_adipose_tissue0.89637840
75MP0005367_renal/urinary_system_phenotyp0.88728544
76MP0000516_abnormal_urinary_system0.88728544
77MP0008775_abnormal_heart_ventricle0.88316183
78MP0003635_abnormal_synaptic_transmissio0.87612293
79MP0006036_abnormal_mitochondrial_physio0.85088530
80MP0010094_abnormal_chromosome_stability0.84797586
81MP0002138_abnormal_hepatobiliary_system0.84368168
82MP0009250_abnormal_appendicular_skeleto0.82297645
83MP0008789_abnormal_olfactory_epithelium0.82067559
84MP0002067_abnormal_sensory_capabilities0.81903115
85MP0001324_abnormal_eye_pigmentation0.81049376
86MP0000230_abnormal_systemic_arterial0.80449492
87MP0002168_other_aberrant_phenotype0.79189106
88MP0003935_abnormal_craniofacial_develop0.78943631
89MP0002063_abnormal_learning/memory/cond0.78719773
90MP0000371_diluted_coat_color0.78398777
91MP0005195_abnormal_posterior_eye0.77482384
92MP0009745_abnormal_behavioral_response0.74020605
93MP0004215_abnormal_myocardial_fiber0.73023981
94MP0005391_vision/eye_phenotype0.72407374
95MP0000778_abnormal_nervous_system0.71318475
96MP0002972_abnormal_cardiac_muscle0.70731729
97MP0002557_abnormal_social/conspecific_i0.70124558
98MP0003633_abnormal_nervous_system0.68309151
99MP0001879_abnormal_lymphatic_vessel0.68186636
100MP0003698_abnormal_male_reproductive0.67319093

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.30486890
2Chromsome breakage (HP:0040012)5.05118670
311 pairs of ribs (HP:0000878)4.38454739
4Aplasia/Hypoplasia of the fovea (HP:0008060)4.14020876
5Hypoplasia of the fovea (HP:0007750)4.14020876
6Reticulocytopenia (HP:0001896)4.04415540
7Nephronophthisis (HP:0000090)4.03514362
8Febrile seizures (HP:0002373)3.97204524
9Hypoplastic ischia (HP:0003175)3.58914296
10Anterior segment dysgenesis (HP:0007700)3.42942604
11Abnormality of the renal collecting system (HP:0004742)3.39630128
12Duplicated collecting system (HP:0000081)3.37953160
13Molar tooth sign on MRI (HP:0002419)3.33625079
14Abnormality of midbrain morphology (HP:0002418)3.33625079
15Calf muscle hypertrophy (HP:0008981)3.25283899
16Congenital stationary night blindness (HP:0007642)3.21545002
17Impaired smooth pursuit (HP:0007772)3.20132621
18Abnormality of the ischium (HP:0003174)3.15310355
19Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.14465860
20Aplasia/Hypoplasia of the uvula (HP:0010293)3.11448977
21Abnormality of the fovea (HP:0000493)3.11116555
22Abnormality of the renal medulla (HP:0100957)3.10051651
23Hemiparesis (HP:0001269)2.97413988
24Muscle hypertrophy of the lower extremities (HP:0008968)2.94152237
25Colon cancer (HP:0003003)2.89750532
26Clubbing of toes (HP:0100760)2.87104123
27Volvulus (HP:0002580)2.79691267
28Aplasia/Hypoplasia of the spleen (HP:0010451)2.76533990
29Abnormality of pyrimidine metabolism (HP:0004353)2.75467231
30Bifid tongue (HP:0010297)2.70866303
31Abnormality of DNA repair (HP:0003254)2.69522302
32Truncal obesity (HP:0001956)2.68569548
33Aplasia/Hypoplasia of the sacrum (HP:0008517)2.67525958
34Aortic aneurysm (HP:0004942)2.59403118
35Meckel diverticulum (HP:0002245)2.57257855
36Papilledema (HP:0001085)2.55876950
37Type II lissencephaly (HP:0007260)2.53004094
38Abnormality of the ileum (HP:0001549)2.52587959
39Bile duct proliferation (HP:0001408)2.52070458
40Abnormal biliary tract physiology (HP:0012439)2.52070458
41Tachypnea (HP:0002789)2.48207343
42Cerebellar dysplasia (HP:0007033)2.46097517
43Germ cell neoplasia (HP:0100728)2.44459439
44Aplasia/Hypoplasia of the macula (HP:0008059)2.43989756
45Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.39707386
46Ectopic kidney (HP:0000086)2.38417112
47Abnormality of ocular smooth pursuit (HP:0000617)2.37941006
48Duplication of thumb phalanx (HP:0009942)2.37809176
49Abnormality of chromosome stability (HP:0003220)2.37783043
50Absent thumb (HP:0009777)2.36227546
51Long clavicles (HP:0000890)2.34645560
52Asplenia (HP:0001746)2.31094414
53Missing ribs (HP:0000921)2.29586559
54Abnormality of the preputium (HP:0100587)2.27720815
55Genetic anticipation (HP:0003743)2.25535241
56Aplasia/Hypoplasia affecting the retina (HP:0008061)2.23915017
57Panhypogammaglobulinemia (HP:0003139)2.23759039
58True hermaphroditism (HP:0010459)2.22514049
59Postural instability (HP:0002172)2.15976394
60Congenital sensorineural hearing impairment (HP:0008527)2.14909866
61Absent radius (HP:0003974)2.14621897
62Esotropia (HP:0000565)2.14389254
63Thyroiditis (HP:0100646)2.12853482
64Epiphyseal dysplasia (HP:0002656)2.10943663
65Retinal dysplasia (HP:0007973)2.07892060
66Limb hypertonia (HP:0002509)2.07482609
67Absent forearm bone (HP:0003953)2.05422974
68Aplasia involving forearm bones (HP:0009822)2.05422974
69Tubular atrophy (HP:0000092)2.04023982
70Hyperventilation (HP:0002883)2.01837203
71Sex reversal (HP:0012245)2.01826894
72Abnormal sex determination (HP:0012244)2.01826894
73Chorioretinal atrophy (HP:0000533)2.01243090
74Triphalangeal thumb (HP:0001199)1.97063433
75Progressive cerebellar ataxia (HP:0002073)1.94580311
76Partial agenesis of the corpus callosum (HP:0001338)1.91032005
77Scanning speech (HP:0002168)1.90952386
78Morphological abnormality of the pyramidal tract (HP:0002062)1.89872215
79Pancreatic fibrosis (HP:0100732)1.88443008
80Aplasia/Hypoplasia of the brainstem (HP:0007362)1.86850618
81Hypoplasia of the brainstem (HP:0002365)1.86850618
82Exercise-induced muscle cramps (HP:0003710)1.85085639
83Abnormality of the axillary hair (HP:0100134)1.84548896
84Abnormality of secondary sexual hair (HP:0009888)1.84548896
85Global brain atrophy (HP:0002283)1.81249448
86Pancreatic cysts (HP:0001737)1.77750033
87Abolished electroretinogram (ERG) (HP:0000550)1.76570481
88Abnormality of the calf musculature (HP:0001430)1.75985706
89Attenuation of retinal blood vessels (HP:0007843)1.75377940
90Truncal ataxia (HP:0002078)1.74039572
91Septate vagina (HP:0001153)1.72915177
92Generalized hypopigmentation of hair (HP:0011358)1.71704126
93Abnormality of the pubic bones (HP:0003172)1.71160496
94Abnormal ciliary motility (HP:0012262)1.71033630
95Small intestinal stenosis (HP:0012848)1.69951971
96Duodenal stenosis (HP:0100867)1.69951971
97Albinism (HP:0001022)1.67346077
98Hypochromic microcytic anemia (HP:0004840)1.66511799
99Hypopigmentation of the fundus (HP:0007894)1.65584214
100Abnormality of the duodenum (HP:0002246)1.65455405

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK18.38158309
2PRKD35.71993349
3FRK3.88217715
4GRK13.00134360
5PBK2.90482266
6PIK3CA2.44493573
7CASK2.19467992
8STK392.11152991
9MKNK22.09062093
10WNK31.98374188
11OBSCN1.97058131
12AKT31.92258542
13ADRBK21.82495215
14PLK41.78640827
15MAPK131.77102783
16DMPK1.75557094
17NUAK11.71306087
18EIF2AK31.65042394
19MARK11.46954392
20MAP4K21.38774675
21FGFR31.34927321
22MAP3K41.32913563
23VRK11.28339617
24NTRK31.18688892
25CAMKK21.17144708
26MKNK11.12108585
27PRKD21.07380775
28PASK1.06514498
29SGK21.03266858
30SCYL21.02080528
31OXSR10.99258222
32LATS10.96166849
33CAMK1G0.92671748
34PRKCE0.91802177
35PIK3CG0.89745383
36PTK2B0.86931382
37CDC70.84927849
38BMPR1B0.80868271
39PRKCH0.80481433
40PRKG20.77443265
41MYLK0.71430203
42CAMK1D0.68985214
43RPS6KB10.67637975
44EPHA40.67411869
45PRKCQ0.67311723
46PRKCG0.67252419
47SGK4940.64371743
48SGK2230.64371743
49RAF10.62902033
50ADRBK10.62492860
51DDR20.59848948
52CSNK1A10.57478456
53CDK30.55422259
54SGK30.55117701
55DYRK1A0.54238838
56PNCK0.52532378
57PHKG20.50263698
58PHKG10.50263698
59FGFR10.50161002
60BRSK20.50148637
61PRKG10.49895026
62RPS6KB20.48909139
63PRKACB0.47803781
64NLK0.44179892
65MAP3K20.41989817
66ATM0.41627626
67CAMK2D0.40928403
68STK30.40643063
69SGK10.39716275
70BCKDK0.39368214
71CAMK10.38878433
72KIT0.38651737
73PRKCZ0.35630411
74CCNB10.34736825
75IKBKE0.34643850
76BCR0.34065479
77NEK60.33309372
78CAMK2G0.33092505
79CDC42BPA0.32625721
80DAPK20.32082680
81KSR10.31225751
82PLK30.30442718
83ACVR1B0.30314514
84PRKACA0.29551223
85MAPK70.28715750
86INSRR0.28209837
87ERBB30.28148277
88TESK20.27703696
89NTRK20.25835405
90MAP3K10.25318135
91TAOK30.24485704
92PRKCB0.24175528
93ABL10.24132885
94MATK0.23949125
95TNIK0.23738421
96PRKDC0.23584227
97ATR0.21753988
98PRKACG0.21736677
99BRD40.21726880
100PLK20.21704654

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.78868128
2Fanconi anemia pathway_Homo sapiens_hsa034603.41697185
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.77679034
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.73852807
5Fatty acid biosynthesis_Homo sapiens_hsa000612.57723467
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.53593757
7Histidine metabolism_Homo sapiens_hsa003402.27497971
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.20719142
9Circadian rhythm_Homo sapiens_hsa047102.15533961
10Fatty acid degradation_Homo sapiens_hsa000712.13353485
11Taste transduction_Homo sapiens_hsa047421.99509566
12Maturity onset diabetes of the young_Homo sapiens_hsa049501.98452729
13beta-Alanine metabolism_Homo sapiens_hsa004101.96601758
14Circadian entrainment_Homo sapiens_hsa047131.86347242
15Butanoate metabolism_Homo sapiens_hsa006501.71726909
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.57392992
17Propanoate metabolism_Homo sapiens_hsa006401.54392795
18Lysine degradation_Homo sapiens_hsa003101.53087633
19Amphetamine addiction_Homo sapiens_hsa050311.52171957
20Glycerolipid metabolism_Homo sapiens_hsa005611.52158482
21Nicotine addiction_Homo sapiens_hsa050331.51557680
22Glutamatergic synapse_Homo sapiens_hsa047241.49068534
23Selenocompound metabolism_Homo sapiens_hsa004501.44834385
24Olfactory transduction_Homo sapiens_hsa047401.38703735
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.38103664
26Peroxisome_Homo sapiens_hsa041461.35564552
27Long-term depression_Homo sapiens_hsa047301.35421994
28Nitrogen metabolism_Homo sapiens_hsa009101.34753877
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.34104107
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.34040453
31Renin secretion_Homo sapiens_hsa049241.31588228
32Phototransduction_Homo sapiens_hsa047441.30376855
33Chemical carcinogenesis_Homo sapiens_hsa052041.28224645
34Salivary secretion_Homo sapiens_hsa049701.25277168
35Retinol metabolism_Homo sapiens_hsa008301.24137215
36Vascular smooth muscle contraction_Homo sapiens_hsa042701.20203016
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18616501
38Serotonergic synapse_Homo sapiens_hsa047261.16506731
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.16142294
40Calcium signaling pathway_Homo sapiens_hsa040201.10720360
41Tryptophan metabolism_Homo sapiens_hsa003801.09729760
42Fatty acid metabolism_Homo sapiens_hsa012121.06822005
43Caffeine metabolism_Homo sapiens_hsa002321.05624356
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.02441851
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00503251
46Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.00453194
47Platelet activation_Homo sapiens_hsa046110.99100317
48Aldosterone synthesis and secretion_Homo sapiens_hsa049250.98837320
49Linoleic acid metabolism_Homo sapiens_hsa005910.98745635
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98203600
51Insulin secretion_Homo sapiens_hsa049110.96868626
52Cocaine addiction_Homo sapiens_hsa050300.95074949
53RNA degradation_Homo sapiens_hsa030180.94238895
54Dilated cardiomyopathy_Homo sapiens_hsa054140.92049094
55Gastric acid secretion_Homo sapiens_hsa049710.87119642
56Ether lipid metabolism_Homo sapiens_hsa005650.85958078
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82589512
58Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.81545330
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80382040
60GABAergic synapse_Homo sapiens_hsa047270.76608360
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76368829
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.75252689
63Mismatch repair_Homo sapiens_hsa034300.74111768
64RNA polymerase_Homo sapiens_hsa030200.73003281
65ABC transporters_Homo sapiens_hsa020100.72591438
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71723041
67PPAR signaling pathway_Homo sapiens_hsa033200.71016616
68Glucagon signaling pathway_Homo sapiens_hsa049220.70853934
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70203044
70Basal transcription factors_Homo sapiens_hsa030220.68454692
71Pancreatic secretion_Homo sapiens_hsa049720.66897077
72Long-term potentiation_Homo sapiens_hsa047200.64730973
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63628088
74Oxytocin signaling pathway_Homo sapiens_hsa049210.56240977
75Bile secretion_Homo sapiens_hsa049760.56054509
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55720855
77Arachidonic acid metabolism_Homo sapiens_hsa005900.55322975
78Glutathione metabolism_Homo sapiens_hsa004800.53868692
79Inositol phosphate metabolism_Homo sapiens_hsa005620.51061156
80Hedgehog signaling pathway_Homo sapiens_hsa043400.49529567
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49502078
82Thyroid hormone synthesis_Homo sapiens_hsa049180.49034971
83Dorso-ventral axis formation_Homo sapiens_hsa043200.48448722
84Morphine addiction_Homo sapiens_hsa050320.46481789
85Dopaminergic synapse_Homo sapiens_hsa047280.46093570
86African trypanosomiasis_Homo sapiens_hsa051430.45841860
87Vitamin digestion and absorption_Homo sapiens_hsa049770.45629610
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.43540021
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43181060
90cAMP signaling pathway_Homo sapiens_hsa040240.42168021
91Gap junction_Homo sapiens_hsa045400.40702509
92mTOR signaling pathway_Homo sapiens_hsa041500.40541708
93Complement and coagulation cascades_Homo sapiens_hsa046100.40156845
94Cholinergic synapse_Homo sapiens_hsa047250.40056242
95Type II diabetes mellitus_Homo sapiens_hsa049300.37513260
96Pyruvate metabolism_Homo sapiens_hsa006200.36628572
97Homologous recombination_Homo sapiens_hsa034400.35631030
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34086763
99Arginine and proline metabolism_Homo sapiens_hsa003300.32828183
100Pyrimidine metabolism_Homo sapiens_hsa002400.31652703

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