ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	interkinetic nuclear migration (GO:0022027)	6.04778284
2	regulation of hexokinase activity (GO:1903299)	5.86013118
3	regulation of glucokinase activity (GO:0033131)	5.86013118
4	regulation of protein polyubiquitination (GO:1902914)	5.83380022
5	relaxation of smooth muscle (GO:0044557)	5.69634517
6	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	5.67857069
7	response to nitrosative stress (GO:0051409)	4.82550390
8	chemosensory behavior (GO:0007635)	4.79851745
9	protein K6-linked ubiquitination (GO:0085020)	4.79775320
10	intra-S DNA damage checkpoint (GO:0031573)	4.75169377
11	positive regulation of mitochondrial fission (GO:0090141)	4.53407510
12	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)	4.51595323
13	fucose catabolic process (GO:0019317)	4.51540020
14	L-fucose metabolic process (GO:0042354)	4.51540020
15	L-fucose catabolic process (GO:0042355)	4.51540020
16	phenylpropanoid metabolic process (GO:0009698)	4.51466666
17	C4-dicarboxylate transport (GO:0015740)	4.49128923
18	startle response (GO:0001964)	4.46594242
19	smooth muscle tissue development (GO:0048745)	4.42033196
20	urinary tract smooth muscle contraction (GO:0014848)	4.36999295
21	negative regulation of protein localization to cell surface (GO:2000009)	4.12211751
22	dopamine transport (GO:0015872)	3.93685918
23	mitotic sister chromatid cohesion (GO:0007064)	3.93309650
24	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	3.86509421
25	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	3.86509421
26	kinetochore assembly (GO:0051382)	3.78460351
27	cell morphogenesis involved in neuron differentiation (GO:0048667)	3.76203601
28	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	3.74835332
29	xenobiotic catabolic process (GO:0042178)	3.60328880
30	neurotransmitter uptake (GO:0001504)	3.59834864
31	nucleus localization (GO:0051647)	3.56013332
32	peristalsis (GO:0030432)	3.55502080
33	regulation of mitochondrial translation (GO:0070129)	3.54702962
34	vitamin transmembrane transport (GO:0035461)	3.51414901
35	regulation of oxidative stress-induced neuron death (GO:1903203)	3.49624482
36	catecholamine transport (GO:0051937)	3.42093201
37	establishment of protein localization to Golgi (GO:0072600)	3.34798244
38	protein targeting to lysosome (GO:0006622)	3.32195109
39	establishment of protein localization to vacuole (GO:0072666)	3.32195109
40	protein targeting to vacuole (GO:0006623)	3.32195109
41	relaxation of muscle (GO:0090075)	3.30119419
42	kinetochore organization (GO:0051383)	3.28911694
43	regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)	3.24025265
44	regulation of endothelial cell chemotaxis (GO:2001026)	3.16230164
45	norepinephrine metabolic process (GO:0042415)	3.12624614
46	response to manganese ion (GO:0010042)	3.08927544
47	translesion synthesis (GO:0019985)	3.08250883
48	phospholipid translocation (GO:0045332)	3.07419802
49	lipid translocation (GO:0034204)	3.07419802
50	positive regulation of actin filament depolymerization (GO:0030836)	3.06890601
51	negative regulation of actin filament bundle assembly (GO:0032232)	3.05087204
52	negative regulation of smooth muscle cell differentiation (GO:0051151)	3.03424816
53	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO	3.01083543
54	negative regulation of smooth muscle contraction (GO:0045986)	3.00937420
55	left/right axis specification (GO:0070986)	3.00443551
56	early endosome to late endosome transport (GO:0045022)	2.99129136
57	detection of light stimulus involved in sensory perception (GO:0050962)	2.98958381
58	detection of light stimulus involved in visual perception (GO:0050908)	2.98958381
59	Sertoli cell development (GO:0060009)	2.88084520
60	positive regulation of calcium ion transmembrane transporter activity (GO:1901021)	2.87619225
61	regulation of mitochondrial fission (GO:0090140)	2.87337436
62	somite development (GO:0061053)	2.86652753
63	zinc ion homeostasis (GO:0055069)	2.85603623
64	platelet dense granule organization (GO:0060155)	2.85389933
65	behavioral response to ethanol (GO:0048149)	2.83763403
66	histone H3-K9 methylation (GO:0051567)	2.81005578
67	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	2.78632479
68	cell proliferation in forebrain (GO:0021846)	2.78050098
69	negative regulation of interleukin-17 production (GO:0032700)	2.73431751
70	neuromuscular synaptic transmission (GO:0007274)	2.72246044
71	nitric oxide mediated signal transduction (GO:0007263)	2.72233149
72	neuronal stem cell maintenance (GO:0097150)	2.70888627
73	regulation of transforming growth factor beta2 production (GO:0032909)	2.70822687
74	protein localization to lysosome (GO:0061462)	2.69431014
75	protein localization to vacuole (GO:0072665)	2.69431014
76	regulation of type B pancreatic cell apoptotic process (GO:2000674)	2.68513165
77	cGMP-mediated signaling (GO:0019934)	2.65672213
78	outer ear morphogenesis (GO:0042473)	2.64801006
79	macroautophagy (GO:0016236)	2.64697658
80	positive regulation of histone methylation (GO:0031062)	2.64620769
81	regulation of skeletal muscle contraction (GO:0014819)	2.64361978
82	ubiquinone biosynthetic process (GO:0006744)	2.62799740
83	regulation of protein glycosylation (GO:0060049)	2.62480390
84	Rac protein signal transduction (GO:0016601)	2.61530477
85	regulation of actin nucleation (GO:0051125)	2.58874247
86	regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	2.58669651
87	protein targeting to Golgi (GO:0000042)	2.57858385
88	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.56780318
89	oligosaccharide catabolic process (GO:0009313)	2.56623981
90	inositol metabolic process (GO:0006020)	2.55745985
91	aggressive behavior (GO:0002118)	2.55180539
92	negative regulation of muscle contraction (GO:0045932)	2.54566645
93	positive regulation of cation channel activity (GO:2001259)	2.53943229
94	branching involved in prostate gland morphogenesis (GO:0060442)	2.52624708
95	ventricular system development (GO:0021591)	2.50541779
96	pseudouridine synthesis (GO:0001522)	2.50009861
97	phasic smooth muscle contraction (GO:0014821)	2.48702826
98	protein polyglutamylation (GO:0018095)	2.45986624
99	ubiquinone metabolic process (GO:0006743)	2.44742995
100	monoubiquitinated protein deubiquitination (GO:0035520)	2.44699192

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.63031521
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.56450817
3	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	3.48192732
4	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	3.31658800
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.30718997
6	IGF1R_20145208_ChIP-Seq_DFB_Human	3.12230887
7	ZNF274_21170338_ChIP-Seq_K562_Hela	3.12224961
8	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.84613668
9	EZH2_22144423_ChIP-Seq_EOC_Human	2.73151809
10	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.68058069
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.54100200
12	EWS_26573619_Chip-Seq_HEK293_Human	2.48653718
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.46893416
14	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.46681252
15	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.42961896
16	P300_19829295_ChIP-Seq_ESCs_Human	2.17197946
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.16393317
18	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.04450746
19	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.99462756
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.96987303
21	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.95907861
22	FUS_26573619_Chip-Seq_HEK293_Human	1.93431578
23	SMAD4_21799915_ChIP-Seq_A2780_Human	1.92538754
24	STAT3_23295773_ChIP-Seq_U87_Human	1.85244862
25	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.84175614
26	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.80921695
27	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.80476492
28	VDR_22108803_ChIP-Seq_LS180_Human	1.77855543
29	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.75115813
30	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.70991556
31	ER_23166858_ChIP-Seq_MCF-7_Human	1.66664653
32	IRF1_19129219_ChIP-ChIP_H3396_Human	1.64317364
33	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.62613643
34	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.59981153
35	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.57928749
36	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.57569878
37	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.57306252
38	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.56952935
39	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.56952935
40	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.56246781
41	BCAT_22108803_ChIP-Seq_LS180_Human	1.51538333
42	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.51236133
43	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.51217895
44	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.50699142
45	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.49725293
46	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.49568335
47	TCF4_23295773_ChIP-Seq_U87_Human	1.45629878
48	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.45478582
49	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.45478582
50	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.45288056
51	CBP_20019798_ChIP-Seq_JUKART_Human	1.45288056
52	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.43124753
53	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.42265875
54	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.41935724
55	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.41546714
56	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.41523379
57	RNF2_27304074_Chip-Seq_NSC_Mouse	1.37515911
58	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.37001753
59	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.35030987
60	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.33565940
61	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.33088762
62	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.32444511
63	RUNX2_22187159_ChIP-Seq_PCA_Human	1.32345864
64	AR_25329375_ChIP-Seq_VCAP_Human	1.31190452
65	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.30687750
66	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.28758657
67	TCF4_22108803_ChIP-Seq_LS180_Human	1.28605898
68	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.27776566
69	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.26536377
70	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.25417268
71	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.22126593
72	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.21357504
73	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.19711135
74	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.18288582
75	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.17858278
76	TP53_18474530_ChIP-ChIP_U2OS_Human	1.17082261
77	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.16541532
78	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.15455717
79	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.14824348
80	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.14772937
81	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.13456120
82	CDX2_22108803_ChIP-Seq_LS180_Human	1.12978534
83	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.10694301
84	TP53_16413492_ChIP-PET_HCT116_Human	1.08980457
85	P53_22387025_ChIP-Seq_ESCs_Mouse	1.08877829
86	TBL1_22424771_ChIP-Seq_293T_Human	1.08220622
87	KDM2B_26808549_Chip-Seq_REH_Human	1.07252578
88	AR_21572438_ChIP-Seq_LNCaP_Human	1.07221994
89	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.06400474
90	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.05324777
91	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.04869446
92	TAF15_26573619_Chip-Seq_HEK293_Human	1.02471821
93	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.01021562
94	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99999636
95	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.99886944
96	NANOG_19829295_ChIP-Seq_ESCs_Human	0.99674976
97	SOX2_19829295_ChIP-Seq_ESCs_Human	0.99674976
98	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.99126217
99	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.98562224
100	WT1_25993318_ChIP-Seq_PODOCYTE_Human	0.95899849

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	6.01709378
2	MP0005174_abnormal_tail_pigmentation	4.07465959
3	MP0002163_abnormal_gland_morphology	3.03420983
4	MP0003195_calcinosis	2.73749357
5	MP0009697_abnormal_copulation	2.66770985
6	MP0005379_endocrine/exocrine_gland_phen	2.63490857
7	MP0006072_abnormal_retinal_apoptosis	2.62358476
8	MP0004885_abnormal_endolymph	2.56870406
9	MP0004147_increased_porphyrin_level	2.51655800
10	MP0008995_early_reproductive_senescence	2.35957001
11	MP0001485_abnormal_pinna_reflex	2.09501001
12	MP0005646_abnormal_pituitary_gland	2.09103259
13	MP0010368_abnormal_lymphatic_system	2.05689935
14	MP0005551_abnormal_eye_electrophysiolog	1.94677908
15	MP0000015_abnormal_ear_pigmentation	1.94149047
16	MP0003879_abnormal_hair_cell	1.93342488
17	MP0008057_abnormal_DNA_replication	1.86019885
18	MP0003045_fibrosis	1.82732448
19	MP0009046_muscle_twitch	1.80990038
20	MP0003567_abnormal_fetal_cardiomyocyte	1.80159021
21	MP0003943_abnormal_hepatobiliary_system	1.79787144
22	MP0006292_abnormal_olfactory_placode	1.78712068
23	MP0004084_abnormal_cardiac_muscle	1.72872954
24	MP0008877_abnormal_DNA_methylation	1.68236145
25	MP0009379_abnormal_foot_pigmentation	1.64346797
26	MP0001501_abnormal_sleep_pattern	1.63853412
27	MP0001486_abnormal_startle_reflex	1.61952993
28	MP0003880_abnormal_central_pattern	1.60527153
29	MP0002095_abnormal_skin_pigmentation	1.56290210
30	MP0003787_abnormal_imprinting	1.55106195
31	MP0005253_abnormal_eye_physiology	1.55065512
32	MP0002272_abnormal_nervous_system	1.54289663
33	MP0001502_abnormal_circadian_rhythm	1.50199358
34	MP0003283_abnormal_digestive_organ	1.48611150
35	MP0003646_muscle_fatigue	1.46044880
36	MP0001968_abnormal_touch/_nociception	1.44696772
37	MP0000566_synostosis	1.43014787
38	MP0002233_abnormal_nose_morphology	1.41277617
39	MP0001963_abnormal_hearing_physiology	1.40227125
40	MP0004036_abnormal_muscle_relaxation	1.38562324
41	MP0000026_abnormal_inner_ear	1.38411770
42	MP0001664_abnormal_digestion	1.32655174
43	MP0002736_abnormal_nociception_after	1.30728883
44	MP0004145_abnormal_muscle_electrophysio	1.29057003
45	MP0008058_abnormal_DNA_repair	1.28695067
46	MP0004043_abnormal_pH_regulation	1.24557514
47	MP0002735_abnormal_chemical_nociception	1.22476203
48	MP0005620_abnormal_muscle_contractility	1.22299999
49	MP0000462_abnormal_digestive_system	1.21711738
50	MP0002106_abnormal_muscle_physiology	1.19640535
51	MP0002229_neurodegeneration	1.14698483
52	MP0005220_abnormal_exocrine_pancreas	1.10385174
53	MP0005369_muscle_phenotype	1.08404372
54	MP0005332_abnormal_amino_acid	1.08339393
55	MP0002572_abnormal_emotion/affect_behav	1.04954038
56	MP0000631_abnormal_neuroendocrine_gland	1.04532308
57	MP0004130_abnormal_muscle_cell	1.03499282
58	MP0005595_abnormal_vascular_smooth	1.02500154
59	MP0003011_delayed_dark_adaptation	1.01978994
60	MP0001293_anophthalmia	1.01709007
61	MP0000751_myopathy	0.98765671
62	MP0001529_abnormal_vocalization	0.97949904
63	MP0002108_abnormal_muscle_morphology	0.96362891
64	MP0005386_behavior/neurological_phenoty	0.95005548
65	MP0004924_abnormal_behavior	0.95005548
66	MP0010386_abnormal_urinary_bladder	0.93485460
67	MP0003755_abnormal_palate_morphology	0.93049527
68	MP0008569_lethality_at_weaning	0.92758497
69	MP0002653_abnormal_ependyma_morphology	0.92742900
70	MP0000749_muscle_degeneration	0.91950285
71	MP0003950_abnormal_plasma_membrane	0.91544663
72	MP0003119_abnormal_digestive_system	0.90093337
73	MP0000049_abnormal_middle_ear	0.89795306
74	MP0000013_abnormal_adipose_tissue	0.89637840
75	MP0000516_abnormal_urinary_system	0.88728544
76	MP0005367_renal/urinary_system_phenotyp	0.88728544
77	MP0008775_abnormal_heart_ventricle	0.88316183
78	MP0003635_abnormal_synaptic_transmissio	0.87612293
79	MP0006036_abnormal_mitochondrial_physio	0.85088530
80	MP0010094_abnormal_chromosome_stability	0.84797586
81	MP0002138_abnormal_hepatobiliary_system	0.84368168
82	MP0009250_abnormal_appendicular_skeleto	0.82297645
83	MP0008789_abnormal_olfactory_epithelium	0.82067559
84	MP0002067_abnormal_sensory_capabilities	0.81903115
85	MP0001324_abnormal_eye_pigmentation	0.81049376
86	MP0000230_abnormal_systemic_arterial	0.80449492
87	MP0002168_other_aberrant_phenotype	0.79189106
88	MP0003935_abnormal_craniofacial_develop	0.78943631
89	MP0002063_abnormal_learning/memory/cond	0.78719773
90	MP0000371_diluted_coat_color	0.78398777
91	MP0005195_abnormal_posterior_eye	0.77482384
92	MP0009745_abnormal_behavioral_response	0.74020605
93	MP0004215_abnormal_myocardial_fiber	0.73023981
94	MP0005391_vision/eye_phenotype	0.72407374
95	MP0000778_abnormal_nervous_system	0.71318475
96	MP0002972_abnormal_cardiac_muscle	0.70731729
97	MP0002557_abnormal_social/conspecific_i	0.70124558
98	MP0003633_abnormal_nervous_system	0.68309151
99	MP0001879_abnormal_lymphatic_vessel	0.68186636
100	MP0003698_abnormal_male_reproductive	0.67319093

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chromosomal breakage induced by crosslinking agents (HP:0003221)	5.30486890
2	Chromsome breakage (HP:0040012)	5.05118670
3	11 pairs of ribs (HP:0000878)	4.38454739
4	Aplasia/Hypoplasia of the fovea (HP:0008060)	4.14020876
5	Hypoplasia of the fovea (HP:0007750)	4.14020876
6	Reticulocytopenia (HP:0001896)	4.04415540
7	Nephronophthisis (HP:0000090)	4.03514362
8	Febrile seizures (HP:0002373)	3.97204524
9	Hypoplastic ischia (HP:0003175)	3.58914296
10	Anterior segment dysgenesis (HP:0007700)	3.42942604
11	Abnormality of the renal collecting system (HP:0004742)	3.39630128
12	Duplicated collecting system (HP:0000081)	3.37953160
13	Abnormality of midbrain morphology (HP:0002418)	3.33625079
14	Molar tooth sign on MRI (HP:0002419)	3.33625079
15	Calf muscle hypertrophy (HP:0008981)	3.25283899
16	Congenital stationary night blindness (HP:0007642)	3.21545002
17	Impaired smooth pursuit (HP:0007772)	3.20132621
18	Abnormality of the ischium (HP:0003174)	3.15310355
19	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	3.14465860
20	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.11448977
21	Abnormality of the fovea (HP:0000493)	3.11116555
22	Abnormality of the renal medulla (HP:0100957)	3.10051651
23	Hemiparesis (HP:0001269)	2.97413988
24	Muscle hypertrophy of the lower extremities (HP:0008968)	2.94152237
25	Colon cancer (HP:0003003)	2.89750532
26	Clubbing of toes (HP:0100760)	2.87104123
27	Volvulus (HP:0002580)	2.79691267
28	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.76533990
29	Abnormality of pyrimidine metabolism (HP:0004353)	2.75467231
30	Bifid tongue (HP:0010297)	2.70866303
31	Abnormality of DNA repair (HP:0003254)	2.69522302
32	Truncal obesity (HP:0001956)	2.68569548
33	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.67525958
34	Aortic aneurysm (HP:0004942)	2.59403118
35	Meckel diverticulum (HP:0002245)	2.57257855
36	Papilledema (HP:0001085)	2.55876950
37	Type II lissencephaly (HP:0007260)	2.53004094
38	Abnormality of the ileum (HP:0001549)	2.52587959
39	Bile duct proliferation (HP:0001408)	2.52070458
40	Abnormal biliary tract physiology (HP:0012439)	2.52070458
41	Tachypnea (HP:0002789)	2.48207343
42	Cerebellar dysplasia (HP:0007033)	2.46097517
43	Germ cell neoplasia (HP:0100728)	2.44459439
44	Aplasia/Hypoplasia of the macula (HP:0008059)	2.43989756
45	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.39707386
46	Ectopic kidney (HP:0000086)	2.38417112
47	Abnormality of ocular smooth pursuit (HP:0000617)	2.37941006
48	Duplication of thumb phalanx (HP:0009942)	2.37809176
49	Abnormality of chromosome stability (HP:0003220)	2.37783043
50	Absent thumb (HP:0009777)	2.36227546
51	Long clavicles (HP:0000890)	2.34645560
52	Asplenia (HP:0001746)	2.31094414
53	Missing ribs (HP:0000921)	2.29586559
54	Abnormality of the preputium (HP:0100587)	2.27720815
55	Genetic anticipation (HP:0003743)	2.25535241
56	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.23915017
57	Panhypogammaglobulinemia (HP:0003139)	2.23759039
58	True hermaphroditism (HP:0010459)	2.22514049
59	Postural instability (HP:0002172)	2.15976394
60	Congenital sensorineural hearing impairment (HP:0008527)	2.14909866
61	Absent radius (HP:0003974)	2.14621897
62	Esotropia (HP:0000565)	2.14389254
63	Thyroiditis (HP:0100646)	2.12853482
64	Epiphyseal dysplasia (HP:0002656)	2.10943663
65	Retinal dysplasia (HP:0007973)	2.07892060
66	Limb hypertonia (HP:0002509)	2.07482609
67	Absent forearm bone (HP:0003953)	2.05422974
68	Aplasia involving forearm bones (HP:0009822)	2.05422974
69	Tubular atrophy (HP:0000092)	2.04023982
70	Hyperventilation (HP:0002883)	2.01837203
71	Sex reversal (HP:0012245)	2.01826894
72	Abnormal sex determination (HP:0012244)	2.01826894
73	Chorioretinal atrophy (HP:0000533)	2.01243090
74	Triphalangeal thumb (HP:0001199)	1.97063433
75	Progressive cerebellar ataxia (HP:0002073)	1.94580311
76	Partial agenesis of the corpus callosum (HP:0001338)	1.91032005
77	Scanning speech (HP:0002168)	1.90952386
78	Morphological abnormality of the pyramidal tract (HP:0002062)	1.89872215
79	Pancreatic fibrosis (HP:0100732)	1.88443008
80	Hypoplasia of the brainstem (HP:0002365)	1.86850618
81	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.86850618
82	Exercise-induced muscle cramps (HP:0003710)	1.85085639
83	Abnormality of the axillary hair (HP:0100134)	1.84548896
84	Abnormality of secondary sexual hair (HP:0009888)	1.84548896
85	Global brain atrophy (HP:0002283)	1.81249448
86	Pancreatic cysts (HP:0001737)	1.77750033
87	Abolished electroretinogram (ERG) (HP:0000550)	1.76570481
88	Abnormality of the calf musculature (HP:0001430)	1.75985706
89	Attenuation of retinal blood vessels (HP:0007843)	1.75377940
90	Truncal ataxia (HP:0002078)	1.74039572
91	Septate vagina (HP:0001153)	1.72915177
92	Generalized hypopigmentation of hair (HP:0011358)	1.71704126
93	Abnormality of the pubic bones (HP:0003172)	1.71160496
94	Abnormal ciliary motility (HP:0012262)	1.71033630
95	Duodenal stenosis (HP:0100867)	1.69951971
96	Small intestinal stenosis (HP:0012848)	1.69951971
97	Albinism (HP:0001022)	1.67346077
98	Hypochromic microcytic anemia (HP:0004840)	1.66511799
99	Hypopigmentation of the fundus (HP:0007894)	1.65584214
100	Abnormality of the duodenum (HP:0002246)	1.65455405

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	8.38158309
2	PRKD3	5.71993349
3	FRK	3.88217715
4	GRK1	3.00134360
5	PBK	2.90482266
6	PIK3CA	2.44493573
7	CASK	2.19467992
8	STK39	2.11152991
9	MKNK2	2.09062093
10	WNK3	1.98374188
11	OBSCN	1.97058131
12	AKT3	1.92258542
13	ADRBK2	1.82495215
14	PLK4	1.78640827
15	MAPK13	1.77102783
16	DMPK	1.75557094
17	NUAK1	1.71306087
18	EIF2AK3	1.65042394
19	MARK1	1.46954392
20	MAP4K2	1.38774675
21	FGFR3	1.34927321
22	MAP3K4	1.32913563
23	VRK1	1.28339617
24	NTRK3	1.18688892
25	CAMKK2	1.17144708
26	MKNK1	1.12108585
27	PRKD2	1.07380775
28	PASK	1.06514498
29	SGK2	1.03266858
30	SCYL2	1.02080528
31	OXSR1	0.99258222
32	LATS1	0.96166849
33	CAMK1G	0.92671748
34	PRKCE	0.91802177
35	PIK3CG	0.89745383
36	PTK2B	0.86931382
37	CDC7	0.84927849
38	BMPR1B	0.80868271
39	PRKCH	0.80481433
40	PRKG2	0.77443265
41	MYLK	0.71430203
42	CAMK1D	0.68985214
43	RPS6KB1	0.67637975
44	EPHA4	0.67411869
45	PRKCQ	0.67311723
46	PRKCG	0.67252419
47	SGK223	0.64371743
48	SGK494	0.64371743
49	RAF1	0.62902033
50	ADRBK1	0.62492860
51	DDR2	0.59848948
52	CSNK1A1	0.57478456
53	CDK3	0.55422259
54	SGK3	0.55117701
55	DYRK1A	0.54238838
56	PNCK	0.52532378
57	PHKG2	0.50263698
58	PHKG1	0.50263698
59	FGFR1	0.50161002
60	BRSK2	0.50148637
61	PRKG1	0.49895026
62	RPS6KB2	0.48909139
63	PRKACB	0.47803781
64	NLK	0.44179892
65	MAP3K2	0.41989817
66	ATM	0.41627626
67	CAMK2D	0.40928403
68	STK3	0.40643063
69	SGK1	0.39716275
70	BCKDK	0.39368214
71	CAMK1	0.38878433
72	KIT	0.38651737
73	PRKCZ	0.35630411
74	CCNB1	0.34736825
75	IKBKE	0.34643850
76	BCR	0.34065479
77	NEK6	0.33309372
78	CAMK2G	0.33092505
79	CDC42BPA	0.32625721
80	DAPK2	0.32082680
81	KSR1	0.31225751
82	PLK3	0.30442718
83	ACVR1B	0.30314514
84	PRKACA	0.29551223
85	MAPK7	0.28715750
86	INSRR	0.28209837
87	ERBB3	0.28148277
88	TESK2	0.27703696
89	NTRK2	0.25835405
90	MAP3K1	0.25318135
91	TAOK3	0.24485704
92	PRKCB	0.24175528
93	ABL1	0.24132885
94	MATK	0.23949125
95	TNIK	0.23738421
96	PRKDC	0.23584227
97	ATR	0.21753988
98	PRKACG	0.21736677
99	BRD4	0.21726880
100	PLK2	0.21704654

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Non-homologous end-joining_Homo sapiens_hsa03450	3.78868128
2	Fanconi anemia pathway_Homo sapiens_hsa03460	3.41697185
3	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.77679034
4	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.73852807
5	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.57723467
6	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.53593757
7	Histidine metabolism_Homo sapiens_hsa00340	2.27497971
8	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.20719142
9	Circadian rhythm_Homo sapiens_hsa04710	2.15533961
10	Fatty acid degradation_Homo sapiens_hsa00071	2.13353485
11	Taste transduction_Homo sapiens_hsa04742	1.99509566
12	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.98452729
13	beta-Alanine metabolism_Homo sapiens_hsa00410	1.96601758
14	Circadian entrainment_Homo sapiens_hsa04713	1.86347242
15	Butanoate metabolism_Homo sapiens_hsa00650	1.71726909
16	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.57392992
17	Propanoate metabolism_Homo sapiens_hsa00640	1.54392795
18	Lysine degradation_Homo sapiens_hsa00310	1.53087633
19	Amphetamine addiction_Homo sapiens_hsa05031	1.52171957
20	Glycerolipid metabolism_Homo sapiens_hsa00561	1.52158482
21	Nicotine addiction_Homo sapiens_hsa05033	1.51557680
22	Glutamatergic synapse_Homo sapiens_hsa04724	1.49068534
23	Selenocompound metabolism_Homo sapiens_hsa00450	1.44834385
24	Olfactory transduction_Homo sapiens_hsa04740	1.38703735
25	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.38103664
26	Peroxisome_Homo sapiens_hsa04146	1.35564552
27	Long-term depression_Homo sapiens_hsa04730	1.35421994
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.34753877
29	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.34104107
30	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.34040453
31	Renin secretion_Homo sapiens_hsa04924	1.31588228
32	Phototransduction_Homo sapiens_hsa04744	1.30376855
33	Chemical carcinogenesis_Homo sapiens_hsa05204	1.28224645
34	Salivary secretion_Homo sapiens_hsa04970	1.25277168
35	Retinol metabolism_Homo sapiens_hsa00830	1.24137215
36	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.20203016
37	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.18616501
38	Serotonergic synapse_Homo sapiens_hsa04726	1.16506731
39	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.16142294
40	Calcium signaling pathway_Homo sapiens_hsa04020	1.10720360
41	Tryptophan metabolism_Homo sapiens_hsa00380	1.09729760
42	Fatty acid metabolism_Homo sapiens_hsa01212	1.06822005
43	Caffeine metabolism_Homo sapiens_hsa00232	1.05624356
44	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.02441851
45	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.00503251
46	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.00453194
47	Platelet activation_Homo sapiens_hsa04611	0.99100317
48	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.98837320
49	Linoleic acid metabolism_Homo sapiens_hsa00591	0.98745635
50	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.98203600
51	Insulin secretion_Homo sapiens_hsa04911	0.96868626
52	Cocaine addiction_Homo sapiens_hsa05030	0.95074949
53	RNA degradation_Homo sapiens_hsa03018	0.94238895
54	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.92049094
55	Gastric acid secretion_Homo sapiens_hsa04971	0.87119642
56	Ether lipid metabolism_Homo sapiens_hsa00565	0.85958078
57	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.82589512
58	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.81545330
59	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.80382040
60	GABAergic synapse_Homo sapiens_hsa04727	0.76608360
61	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.76368829
62	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.75252689
63	Mismatch repair_Homo sapiens_hsa03430	0.74111768
64	RNA polymerase_Homo sapiens_hsa03020	0.73003281
65	ABC transporters_Homo sapiens_hsa02010	0.72591438
66	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.71723041
67	PPAR signaling pathway_Homo sapiens_hsa03320	0.71016616
68	Glucagon signaling pathway_Homo sapiens_hsa04922	0.70853934
69	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.70203044
70	Basal transcription factors_Homo sapiens_hsa03022	0.68454692
71	Pancreatic secretion_Homo sapiens_hsa04972	0.66897077
72	Long-term potentiation_Homo sapiens_hsa04720	0.64730973
73	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.63628088
74	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.56240977
75	Bile secretion_Homo sapiens_hsa04976	0.56054509
76	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.55720855
77	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.55322975
78	Glutathione metabolism_Homo sapiens_hsa00480	0.53868692
79	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.51061156
80	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.49529567
81	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.49502078
82	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.49034971
83	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.48448722
84	Morphine addiction_Homo sapiens_hsa05032	0.46481789
85	Dopaminergic synapse_Homo sapiens_hsa04728	0.46093570
86	African trypanosomiasis_Homo sapiens_hsa05143	0.45841860
87	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.45629610
88	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.43540021
89	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.43181060
90	cAMP signaling pathway_Homo sapiens_hsa04024	0.42168021
91	Gap junction_Homo sapiens_hsa04540	0.40702509
92	mTOR signaling pathway_Homo sapiens_hsa04150	0.40541708
93	Complement and coagulation cascades_Homo sapiens_hsa04610	0.40156845
94	Cholinergic synapse_Homo sapiens_hsa04725	0.40056242
95	Type II diabetes mellitus_Homo sapiens_hsa04930	0.37513260
96	Pyruvate metabolism_Homo sapiens_hsa00620	0.36628572
97	Homologous recombination_Homo sapiens_hsa03440	0.35631030
98	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.34086763
99	Arginine and proline metabolism_Homo sapiens_hsa00330	0.32828183
100	Pyrimidine metabolism_Homo sapiens_hsa00240	0.31652703

ZNF33BP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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