ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	5.41176086
2	negative regulation of cytosolic calcium ion concentration (GO:0051481)	4.64942475
3	nucleobase catabolic process (GO:0046113)	4.44409079
4	inositol phosphate catabolic process (GO:0071545)	4.39530683
5	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	4.30950102
6	phosphorylated carbohydrate dephosphorylation (GO:0046838)	4.04615586
7	inositol phosphate dephosphorylation (GO:0046855)	4.04615586
8	behavioral response to ethanol (GO:0048149)	4.01532919
9	synapsis (GO:0007129)	3.90051870
10	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.87528398
11	nonmotile primary cilium assembly (GO:0035058)	3.75579841
12	protein complex biogenesis (GO:0070271)	3.74882368
13	neural tube formation (GO:0001841)	3.65339641
14	amino acid salvage (GO:0043102)	3.64118772
15	L-methionine salvage (GO:0071267)	3.64118772
16	L-methionine biosynthetic process (GO:0071265)	3.64118772
17	piRNA metabolic process (GO:0034587)	3.58433459
18	presynaptic membrane organization (GO:0097090)	3.46711762
19	positive regulation of mitochondrial fission (GO:0090141)	3.46570135
20	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.45550482
21	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.45550482
22	NADH dehydrogenase complex assembly (GO:0010257)	3.45550482
23	ubiquinone biosynthetic process (GO:0006744)	3.41333637
24	cytochrome complex assembly (GO:0017004)	3.40824411
25	regulation of cilium movement (GO:0003352)	3.37783948
26	adult feeding behavior (GO:0008343)	3.37146387
27	respiratory chain complex IV assembly (GO:0008535)	3.37013578
28	presynaptic membrane assembly (GO:0097105)	3.35659197
29	mitochondrial respiratory chain complex assembly (GO:0033108)	3.31312647
30	brain morphogenesis (GO:0048854)	3.27801393
31	cilium morphogenesis (GO:0060271)	3.25113024
32	cellular ketone body metabolic process (GO:0046950)	3.22521670
33	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.22156146
34	retinal cone cell development (GO:0046549)	3.14430086
35	glycosphingolipid biosynthetic process (GO:0006688)	3.13204863
36	polyol catabolic process (GO:0046174)	3.12994962
37	ubiquinone metabolic process (GO:0006743)	3.12226666
38	proline transport (GO:0015824)	3.08972108
39	replication fork processing (GO:0031297)	3.04165671
40	regulation of feeding behavior (GO:0060259)	3.02295040
41	aggressive behavior (GO:0002118)	2.90391383
42	resolution of meiotic recombination intermediates (GO:0000712)	2.86942533
43	neurotransmitter catabolic process (GO:0042135)	2.86158841
44	ketone body metabolic process (GO:1902224)	2.80420560
45	gamma-aminobutyric acid transport (GO:0015812)	2.76796802
46	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.75057366
47	axonal fasciculation (GO:0007413)	2.73819699
48	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.71362999
49	axoneme assembly (GO:0035082)	2.70533272
50	protein polyglutamylation (GO:0018095)	2.69828252
51	DNA methylation involved in gamete generation (GO:0043046)	2.69440838
52	quinone biosynthetic process (GO:1901663)	2.64919794
53	acrosome reaction (GO:0007340)	2.64571794
54	alanine transport (GO:0032328)	2.64138808
55	water-soluble vitamin biosynthetic process (GO:0042364)	2.63716361
56	epithelial cilium movement (GO:0003351)	2.60801688
57	DNA double-strand break processing (GO:0000729)	2.59768738
58	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.59115145
59	photoreceptor cell maintenance (GO:0045494)	2.59078978
60	C4-dicarboxylate transport (GO:0015740)	2.58959671
61	histone H2A acetylation (GO:0043968)	2.56014119
62	neuron recognition (GO:0008038)	2.55756236
63	protein-cofactor linkage (GO:0018065)	2.55658246
64	intraciliary transport (GO:0042073)	2.53956373
65	negative regulation of cAMP-mediated signaling (GO:0043951)	2.53912447
66	methionine biosynthetic process (GO:0009086)	2.53857667
67	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.53792843
68	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.53792843
69	GPI anchor metabolic process (GO:0006505)	2.53003944
70	C-terminal protein lipidation (GO:0006501)	2.52965883
71	male meiosis I (GO:0007141)	2.50253436
72	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.48311561
73	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.47934480
74	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	2.47926856
75	glycerophospholipid catabolic process (GO:0046475)	2.47631282
76	C-terminal protein amino acid modification (GO:0018410)	2.46848466
77	mannosylation (GO:0097502)	2.46699321
78	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.46667893
79	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.46195946
80	preassembly of GPI anchor in ER membrane (GO:0016254)	2.46139602
81	neuron cell-cell adhesion (GO:0007158)	2.46039885
82	regulation of acrosome reaction (GO:0060046)	2.41941948
83	detection of calcium ion (GO:0005513)	2.41712393
84	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.41614281
85	establishment of mitochondrion localization (GO:0051654)	2.39579625
86	inner ear receptor stereocilium organization (GO:0060122)	2.39344152
87	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.37083118
88	tryptophan catabolic process (GO:0006569)	2.36064227
89	indole-containing compound catabolic process (GO:0042436)	2.36064227
90	indolalkylamine catabolic process (GO:0046218)	2.36064227
91	S-adenosylmethionine metabolic process (GO:0046500)	2.34094226
92	cilium organization (GO:0044782)	2.32852202
93	transmission of nerve impulse (GO:0019226)	2.32282328
94	positive regulation of histone H3-K4 methylation (GO:0051571)	2.31051157
95	regulation of coenzyme metabolic process (GO:0051196)	2.30345378
96	regulation of cofactor metabolic process (GO:0051193)	2.30345378
97	melanosome transport (GO:0032402)	2.30034676
98	positive regulation of amino acid transport (GO:0051957)	2.29510392
99	protein localization to cilium (GO:0061512)	2.29282558
100	glycolipid biosynthetic process (GO:0009247)	2.28708037

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.37043195
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.62397508
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.02558679
4	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.77452623
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.73706338
6	TAF15_26573619_Chip-Seq_HEK293_Human	2.70757514
7	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.66695261
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.53058551
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.49494760
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.49026054
11	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.48210403
12	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.47196961
13	FUS_26573619_Chip-Seq_HEK293_Human	2.41849717
14	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.38189129
15	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.37690040
16	EZH2_22144423_ChIP-Seq_EOC_Human	2.31333660
17	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.25301191
18	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.18812127
19	EWS_26573619_Chip-Seq_HEK293_Human	2.15629831
20	VDR_22108803_ChIP-Seq_LS180_Human	2.14541530
21	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.09007541
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.03007346
23	P300_19829295_ChIP-Seq_ESCs_Human	2.02383748
24	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.01598791
25	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.00882355
26	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.76724866
27	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.70857207
28	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.59276604
29	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.58816674
30	ELK1_19687146_ChIP-ChIP_HELA_Human	1.56586629
31	REST_21632747_ChIP-Seq_MESCs_Mouse	1.55015615
32	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.53298826
33	ER_23166858_ChIP-Seq_MCF-7_Human	1.52718507
34	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.51483446
35	AR_25329375_ChIP-Seq_VCAP_Human	1.50397171
36	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.49704120
37	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.48137809
38	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.47850524
39	BCAT_22108803_ChIP-Seq_LS180_Human	1.46246938
40	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.45421075
41	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.44869012
42	VDR_23849224_ChIP-Seq_CD4+_Human	1.44350894
43	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.43912742
44	SMAD4_21799915_ChIP-Seq_A2780_Human	1.43601720
45	TP53_22573176_ChIP-Seq_HFKS_Human	1.43483786
46	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.41608381
47	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.34608377
48	RNF2_27304074_Chip-Seq_NSC_Mouse	1.34243579
49	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.34193787
50	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.30555892
51	CBP_20019798_ChIP-Seq_JUKART_Human	1.28734582
52	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.28734582
53	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.26707315
54	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.25349665
55	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.25167859
56	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.24058293
57	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.23668257
58	TCF4_23295773_ChIP-Seq_U87_Human	1.23123849
59	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.21716105
60	* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.21330930
61	STAT3_23295773_ChIP-Seq_U87_Human	1.21108199
62	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.21106099
63	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.20713500
64	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.19487754
65	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.19464227
66	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.18299706
67	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.18299706
68	IRF1_19129219_ChIP-ChIP_H3396_Human	1.18055958
69	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.17880033
70	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.15624083
71	HTT_18923047_ChIP-ChIP_STHdh_Human	1.14522683
72	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.14410119
73	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.13416077
74	SOX2_19829295_ChIP-Seq_ESCs_Human	1.13368280
75	NANOG_19829295_ChIP-Seq_ESCs_Human	1.13368280
76	* RUNX2_22187159_ChIP-Seq_PCA_Human	1.13333007
77	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.12997461
78	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.12878376
79	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.11960001
80	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.09312399
81	P53_22387025_ChIP-Seq_ESCs_Mouse	1.09214647
82	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.07964886
83	FOXP3_21729870_ChIP-Seq_TREG_Human	1.06377852
84	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.05840020
85	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.04101756
86	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.03044974
87	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.02929561
88	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.02430223
89	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.01422112
90	* SOX2_21211035_ChIP-Seq_LN229_Gbm	1.01257898
91	TCF4_22108803_ChIP-Seq_LS180_Human	0.99937485
92	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.99400709
93	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.98460867
94	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98329837
95	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.97273554
96	NCOR_22424771_ChIP-Seq_293T_Human	0.96698666
97	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.94858031
98	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.94128132
99	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.94062039
100	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.93991155

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003787_abnormal_imprinting	3.52656221
2	MP0001968_abnormal_touch/_nociception	3.23899231
3	MP0003880_abnormal_central_pattern	2.85093129
4	MP0001529_abnormal_vocalization	2.77726922
5	MP0008877_abnormal_DNA_methylation	2.60989906
6	MP0002822_catalepsy	2.53296614
7	MP0002102_abnormal_ear_morphology	2.47093022
8	MP0001984_abnormal_olfaction	2.44535317
9	MP0002736_abnormal_nociception_after	2.41180091
10	MP0005423_abnormal_somatic_nervous	2.34079815
11	MP0005646_abnormal_pituitary_gland	2.23175522
12	MP0008789_abnormal_olfactory_epithelium	2.19704709
13	MP0002735_abnormal_chemical_nociception	2.08635901
14	MP0004270_analgesia	2.02836671
15	MP0005645_abnormal_hypothalamus_physiol	2.02338008
16	MP0009745_abnormal_behavioral_response	1.99707945
17	MP0005551_abnormal_eye_electrophysiolog	1.97582873
18	MP0009046_muscle_twitch	1.93568672
19	MP0002837_dystrophic_cardiac_calcinosis	1.91781538
20	MP0005394_taste/olfaction_phenotype	1.88702306
21	MP0005499_abnormal_olfactory_system	1.88702306
22	MP0006072_abnormal_retinal_apoptosis	1.82589478
23	MP0006292_abnormal_olfactory_placode	1.82451339
24	MP0002272_abnormal_nervous_system	1.77224975
25	MP0006276_abnormal_autonomic_nervous	1.75835063
26	MP0002572_abnormal_emotion/affect_behav	1.73407797
27	MP0008058_abnormal_DNA_repair	1.72067576
28	MP0001986_abnormal_taste_sensitivity	1.71845820
29	MP0000516_abnormal_urinary_system	1.70853427
30	MP0005367_renal/urinary_system_phenotyp	1.70853427
31	MP0002909_abnormal_adrenal_gland	1.70615420
32	MP0002734_abnormal_mechanical_nocicepti	1.67146835
33	MP0003635_abnormal_synaptic_transmissio	1.65017023
34	MP0005253_abnormal_eye_physiology	1.58993232
35	MP0001905_abnormal_dopamine_level	1.58983638
36	MP0002733_abnormal_thermal_nociception	1.57687750
37	MP0002234_abnormal_pharynx_morphology	1.57502494
38	MP0000778_abnormal_nervous_system	1.55461554
39	MP0001970_abnormal_pain_threshold	1.55185246
40	MP0000427_abnormal_hair_cycle	1.50901385
41	MP0002063_abnormal_learning/memory/cond	1.50692595
42	MP0002064_seizures	1.46901098
43	MP0002653_abnormal_ependyma_morphology	1.46585165
44	MP0002557_abnormal_social/conspecific_i	1.46454942
45	MP0003718_maternal_effect	1.45689477
46	MP0001486_abnormal_startle_reflex	1.44343528
47	MP0004859_abnormal_synaptic_plasticity	1.40309891
48	MP0006035_abnormal_mitochondrial_morpho	1.38949532
49	MP0005386_behavior/neurological_phenoty	1.38319028
50	MP0004924_abnormal_behavior	1.38319028
51	MP0009780_abnormal_chondrocyte_physiolo	1.35957560
52	MP0003121_genomic_imprinting	1.35602417
53	MP0005379_endocrine/exocrine_gland_phen	1.34449075
54	MP0000631_abnormal_neuroendocrine_gland	1.32402650
55	MP0002876_abnormal_thyroid_physiology	1.28426722
56	MP0004142_abnormal_muscle_tone	1.25486982
57	MP0002067_abnormal_sensory_capabilities	1.22125714
58	MP0002184_abnormal_innervation	1.18942846
59	MP0002638_abnormal_pupillary_reflex	1.13075641
60	MP0005248_abnormal_Harderian_gland	1.12400949
61	MP0002882_abnormal_neuron_morphology	1.09722877
62	MP0004147_increased_porphyrin_level	1.09369955
63	MP0001501_abnormal_sleep_pattern	1.07389219
64	MP0002069_abnormal_eating/drinking_beha	1.06604935
65	MP0004811_abnormal_neuron_physiology	1.03908401
66	MP0004215_abnormal_myocardial_fiber	1.00694886
67	MP0008872_abnormal_physiological_respon	0.99941665
68	MP0002752_abnormal_somatic_nervous	0.98863880
69	MP0002163_abnormal_gland_morphology	0.96698090
70	MP0000955_abnormal_spinal_cord	0.95960454
71	MP0004043_abnormal_pH_regulation	0.95928047
72	MP0003633_abnormal_nervous_system	0.94990399
73	MP0002229_neurodegeneration	0.93167881
74	MP0002233_abnormal_nose_morphology	0.91922364
75	MP0005195_abnormal_posterior_eye	0.91837252
76	MP0000647_abnormal_sebaceous_gland	0.90476569
77	MP0001929_abnormal_gametogenesis	0.89577490
78	MP0004085_abnormal_heartbeat	0.88102072
79	MP0002751_abnormal_autonomic_nervous	0.86835845
80	MP0002693_abnormal_pancreas_physiology	0.86206820
81	MP0003698_abnormal_male_reproductive	0.85811067
82	MP0003119_abnormal_digestive_system	0.84758613
83	MP0001299_abnormal_eye_distance/	0.84444699
84	MP0005410_abnormal_fertilization	0.83955422
85	MP0003122_maternal_imprinting	0.82557005
86	MP0003137_abnormal_impulse_conducting	0.82340657
87	MP0004885_abnormal_endolymph	0.81962089
88	MP0008875_abnormal_xenobiotic_pharmacok	0.81101587
89	MP0006036_abnormal_mitochondrial_physio	0.80856614
90	MP0005174_abnormal_tail_pigmentation	0.80692539
91	MP0002210_abnormal_sex_determination	0.80356207
92	MP0002066_abnormal_motor_capabilities/c	0.79458243
93	MP0001944_abnormal_pancreas_morphology	0.77426416
94	MP0002928_abnormal_bile_duct	0.77160221
95	MP0000013_abnormal_adipose_tissue	0.75799459
96	MP0002152_abnormal_brain_morphology	0.73307235
97	MP0005084_abnormal_gallbladder_morpholo	0.71676690
98	MP0001502_abnormal_circadian_rhythm	0.71412770
99	MP0001919_abnormal_reproductive_system	0.70927912
100	MP0005389_reproductive_system_phenotype	0.70324076

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic fibrosis (HP:0100732)	3.66238228
2	Intestinal atresia (HP:0011100)	3.49684956
3	Medial flaring of the eyebrow (HP:0010747)	3.46239078
4	Colon cancer (HP:0003003)	3.41859559
5	Pancreatic cysts (HP:0001737)	3.39103303
6	Gait imbalance (HP:0002141)	3.33266504
7	Abnormality of midbrain morphology (HP:0002418)	3.16411870
8	Molar tooth sign on MRI (HP:0002419)	3.16411870
9	Nephronophthisis (HP:0000090)	3.13019902
10	Renal cortical cysts (HP:0000803)	3.12191291
11	Congenital primary aphakia (HP:0007707)	3.11191933
12	Gaze-evoked nystagmus (HP:0000640)	3.09108947
13	True hermaphroditism (HP:0010459)	3.07065911
14	Abnormality of the renal cortex (HP:0011035)	3.05672602
15	Nephrogenic diabetes insipidus (HP:0009806)	2.89409205
16	Acute necrotizing encephalopathy (HP:0006965)	2.80793214
17	Abolished electroretinogram (ERG) (HP:0000550)	2.75004890
18	Progressive macrocephaly (HP:0004481)	2.74491688
19	Absent speech (HP:0001344)	2.62110694
20	Methylmalonic acidemia (HP:0002912)	2.61678763
21	Abnormality of the renal medulla (HP:0100957)	2.57831700
22	Hyperventilation (HP:0002883)	2.57532561
23	3-Methylglutaconic aciduria (HP:0003535)	2.55513592
24	Congenital stationary night blindness (HP:0007642)	2.53936605
25	Abnormal mitochondria in muscle tissue (HP:0008316)	2.50292653
26	Thyroid-stimulating hormone excess (HP:0002925)	2.48736503
27	Hepatic necrosis (HP:0002605)	2.48592129
28	Pachygyria (HP:0001302)	2.47970252
29	Mitochondrial inheritance (HP:0001427)	2.45697041
30	Abnormality of the labia minora (HP:0012880)	2.42547400
31	Acute encephalopathy (HP:0006846)	2.39236832
32	Hemiparesis (HP:0001269)	2.38962985
33	Hypothermia (HP:0002045)	2.38457680
34	Hepatocellular necrosis (HP:0001404)	2.36910382
35	Volvulus (HP:0002580)	2.36146368
36	Attenuation of retinal blood vessels (HP:0007843)	2.35473903
37	Increased CSF lactate (HP:0002490)	2.30901262
38	Bile duct proliferation (HP:0001408)	2.30416593
39	Abnormal biliary tract physiology (HP:0012439)	2.30416593
40	Pendular nystagmus (HP:0012043)	2.29786073
41	Lissencephaly (HP:0001339)	2.26163505
42	Polyphagia (HP:0002591)	2.24429378
43	Anencephaly (HP:0002323)	2.23957795
44	Genital tract atresia (HP:0001827)	2.22998391
45	Ependymoma (HP:0002888)	2.22081335
46	Type II lissencephaly (HP:0007260)	2.20522138
47	Tubulointerstitial nephritis (HP:0001970)	2.20205175
48	Cystic liver disease (HP:0006706)	2.17933782
49	Decreased testicular size (HP:0008734)	2.16179152
50	Poor coordination (HP:0002370)	2.14290723
51	Failure to thrive in infancy (HP:0001531)	2.14135211
52	Progressive inability to walk (HP:0002505)	2.13660008
53	Astrocytoma (HP:0009592)	2.13027073
54	Abnormality of the astrocytes (HP:0100707)	2.13027073
55	Hypsarrhythmia (HP:0002521)	2.11613733
56	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.10563979
57	EEG with generalized epileptiform discharges (HP:0011198)	2.06316849
58	Abnormal protein glycosylation (HP:0012346)	2.05452962
59	Abnormal glycosylation (HP:0012345)	2.05452962
60	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.05452962
61	Abnormal protein N-linked glycosylation (HP:0012347)	2.05452962
62	Vaginal atresia (HP:0000148)	2.03426156
63	Generalized aminoaciduria (HP:0002909)	2.01546065
64	Chorioretinal atrophy (HP:0000533)	2.00944896
65	Severe muscular hypotonia (HP:0006829)	1.99627325
66	Methylmalonic aciduria (HP:0012120)	1.99424073
67	Bony spicule pigmentary retinopathy (HP:0007737)	1.99132477
68	Cerebral edema (HP:0002181)	1.98045356
69	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.97512490
70	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.97512490
71	Epileptiform EEG discharges (HP:0011182)	1.94736493
72	Specific learning disability (HP:0001328)	1.92513647
73	Widely spaced teeth (HP:0000687)	1.91690539
74	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.90241038
75	Abnormality of alanine metabolism (HP:0010916)	1.90241038
76	Hyperalaninemia (HP:0003348)	1.90241038
77	Postaxial hand polydactyly (HP:0001162)	1.88906522
78	Sclerocornea (HP:0000647)	1.88746384
79	Broad-based gait (HP:0002136)	1.87936769
80	Polydipsia (HP:0001959)	1.87436798
81	Abnormal drinking behavior (HP:0030082)	1.87436798
82	Hyperglycinemia (HP:0002154)	1.86174147
83	Focal motor seizures (HP:0011153)	1.86096609
84	Optic disc pallor (HP:0000543)	1.85746744
85	Abnormality of vitamin B metabolism (HP:0004340)	1.85055793
86	Narrow forehead (HP:0000341)	1.84325760
87	Retinal dysplasia (HP:0007973)	1.83612293
88	Tongue fasciculations (HP:0001308)	1.81608698
89	Febrile seizures (HP:0002373)	1.80444027
90	Inability to walk (HP:0002540)	1.79655016
91	Furrowed tongue (HP:0000221)	1.79539389
92	Focal seizures (HP:0007359)	1.78731279
93	Neoplasm of the adrenal cortex (HP:0100641)	1.78413084
94	Broad foot (HP:0001769)	1.76465875
95	Optic nerve hypoplasia (HP:0000609)	1.76257973
96	Male pseudohermaphroditism (HP:0000037)	1.75891272
97	Aqueductal stenosis (HP:0002410)	1.75737703
98	Increased serum lactate (HP:0002151)	1.74736146
99	Tubular atrophy (HP:0000092)	1.74085975
100	Large for gestational age (HP:0001520)	1.73613723

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.45643885
2	CASK	4.04892802
3	MAP3K4	3.63537584
4	MAP2K7	3.22765902
5	MAP4K2	3.04896058
6	ADRBK2	2.99956142
7	MARK1	2.93981114
8	NUAK1	2.64926982
9	WNK3	2.43950490
10	TRIM28	2.33509070
11	ERBB3	2.29997825
12	BMPR1B	2.25597321
13	MAPK13	2.05710474
14	INSRR	1.66735656
15	PNCK	1.63353992
16	MKNK1	1.57105341
17	CSNK1G3	1.55448454
18	PAK3	1.51357926
19	CSNK1G2	1.44872332
20	CSNK1G1	1.43646761
21	ZAK	1.41899466
22	BCR	1.39978249
23	DYRK2	1.39296345
24	PINK1	1.34530550
25	CSNK1A1L	1.33007898
26	BCKDK	1.32416529
27	FGFR2	1.30314429
28	PHKG1	1.29444606
29	PHKG2	1.29444606
30	MAP2K4	1.27640294
31	MST4	1.24421357
32	TNK2	1.21449913
33	GRK1	1.19968226
34	MAPKAPK5	1.17086278
35	TAOK3	1.16323899
36	PRKCG	1.11574357
37	CAMKK2	1.08555056
38	PRKCE	1.05685866
39	CCNB1	1.03802279
40	DAPK2	0.97165192
41	PTK2B	0.94465747
42	EPHA4	0.94457676
43	PIM2	0.93834074
44	EPHA3	0.88400584
45	CAMK2A	0.82105924
46	TAF1	0.81619899
47	MINK1	0.81556987
48	PRKD3	0.81284897
49	ADRBK1	0.77439521
50	PKN1	0.76899801
51	MKNK2	0.75128624
52	OXSR1	0.74457213
53	DYRK3	0.71834614
54	NTRK2	0.64505805
55	DYRK1A	0.63959150
56	PLK2	0.63254355
57	CDK5	0.62592391
58	EIF2AK2	0.62148218
59	PRKAA1	0.61613618
60	PAK6	0.61080125
61	SIK2	0.57595954
62	CSNK1D	0.56644415
63	PLK1	0.52864861
64	SRPK1	0.52105056
65	STK3	0.51679045
66	EIF2AK1	0.51023306
67	EIF2AK3	0.50907072
68	PRKCZ	0.50715324
69	YES1	0.50572684
70	RPS6KA5	0.50344783
71	DAPK1	0.50043514
72	WNK4	0.49946721
73	VRK1	0.49144121
74	STK11	0.48798572
75	UHMK1	0.48538020
76	MAP2K6	0.48044046
77	TSSK6	0.47020752
78	GRK5	0.46648325
79	CAMK2D	0.46296006
80	TGFBR1	0.45226696
81	BRSK2	0.44714916
82	ROCK1	0.44379771
83	MAP3K12	0.42315130
84	NTRK3	0.39549820
85	PRKACA	0.39412526
86	BMPR2	0.39324522
87	ATM	0.38794660
88	PRKG1	0.38262006
89	AKT3	0.38165443
90	CDK9	0.37142551
91	PLK4	0.36441284
92	PRKACB	0.36149226
93	GRK7	0.35774947
94	TIE1	0.35266358
95	MAP3K5	0.35118807
96	STK39	0.34983435
97	BUB1	0.34703631
98	CSNK1A1	0.33789527
99	PLK3	0.32763198
100	PRKCQ	0.32498499

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.33046700
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.07881763
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.92041185
4	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.71388283
5	Protein export_Homo sapiens_hsa03060	2.65584327
6	Butanoate metabolism_Homo sapiens_hsa00650	2.59473352
7	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.41554225
8	Phototransduction_Homo sapiens_hsa04744	2.40262556
9	Oxidative phosphorylation_Homo sapiens_hsa00190	2.37262539
10	Collecting duct acid secretion_Homo sapiens_hsa04966	2.27362485
11	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.13654153
12	Nicotine addiction_Homo sapiens_hsa05033	2.06831935
13	RNA polymerase_Homo sapiens_hsa03020	2.01040803
14	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.93911627
15	Propanoate metabolism_Homo sapiens_hsa00640	1.90863217
16	Parkinsons disease_Homo sapiens_hsa05012	1.80160168
17	Basal transcription factors_Homo sapiens_hsa03022	1.78605058
18	RNA degradation_Homo sapiens_hsa03018	1.76356567
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.76066545
20	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.59111564
21	Regulation of autophagy_Homo sapiens_hsa04140	1.52085428
22	Nitrogen metabolism_Homo sapiens_hsa00910	1.47518962
23	Taste transduction_Homo sapiens_hsa04742	1.47368756
24	GABAergic synapse_Homo sapiens_hsa04727	1.45969509
25	Selenocompound metabolism_Homo sapiens_hsa00450	1.41814838
26	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.39440917
27	Folate biosynthesis_Homo sapiens_hsa00790	1.37659327
28	Fatty acid elongation_Homo sapiens_hsa00062	1.32027524
29	Morphine addiction_Homo sapiens_hsa05032	1.31560705
30	Peroxisome_Homo sapiens_hsa04146	1.31353477
31	Insulin secretion_Homo sapiens_hsa04911	1.26503196
32	Non-homologous end-joining_Homo sapiens_hsa03450	1.23385533
33	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.21780242
34	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.21748305
35	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.14400006
36	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.09532649
37	Linoleic acid metabolism_Homo sapiens_hsa00591	1.08973838
38	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.07121891
39	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.04690176
40	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.03570048
41	Ether lipid metabolism_Homo sapiens_hsa00565	1.03052720
42	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.01996514
43	Glutamatergic synapse_Homo sapiens_hsa04724	1.01895471
44	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.99942892
45	Circadian entrainment_Homo sapiens_hsa04713	0.99769791
46	Dopaminergic synapse_Homo sapiens_hsa04728	0.98468749
47	Sphingolipid metabolism_Homo sapiens_hsa00600	0.97958845
48	Olfactory transduction_Homo sapiens_hsa04740	0.97788513
49	beta-Alanine metabolism_Homo sapiens_hsa00410	0.95999520
50	Huntingtons disease_Homo sapiens_hsa05016	0.95679238
51	Base excision repair_Homo sapiens_hsa03410	0.95500866
52	Circadian rhythm_Homo sapiens_hsa04710	0.92125657
53	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.91592597
54	Alzheimers disease_Homo sapiens_hsa05010	0.90757898
55	Homologous recombination_Homo sapiens_hsa03440	0.86017127
56	Tryptophan metabolism_Homo sapiens_hsa00380	0.85817933
57	Cardiac muscle contraction_Homo sapiens_hsa04260	0.83752584
58	Sulfur relay system_Homo sapiens_hsa04122	0.83708389
59	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.81264793
60	Retinol metabolism_Homo sapiens_hsa00830	0.79430945
61	One carbon pool by folate_Homo sapiens_hsa00670	0.79266707
62	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.76534089
63	Serotonergic synapse_Homo sapiens_hsa04726	0.75862915
64	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.73997974
65	Metabolic pathways_Homo sapiens_hsa01100	0.73858929
66	ABC transporters_Homo sapiens_hsa02010	0.73306049
67	Steroid biosynthesis_Homo sapiens_hsa00100	0.73142765
68	Purine metabolism_Homo sapiens_hsa00230	0.73008933
69	Vibrio cholerae infection_Homo sapiens_hsa05110	0.72436117
70	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.70818820
71	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.70647292
72	Long-term depression_Homo sapiens_hsa04730	0.69992678
73	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.69696777
74	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.69239295
75	Proteasome_Homo sapiens_hsa03050	0.68012007
76	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.67422352
77	Cocaine addiction_Homo sapiens_hsa05030	0.65423849
78	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.62004041
79	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.61983117
80	Pyrimidine metabolism_Homo sapiens_hsa00240	0.59865459
81	Amphetamine addiction_Homo sapiens_hsa05031	0.59839084
82	Salivary secretion_Homo sapiens_hsa04970	0.57002877
83	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.56595774
84	Glycerolipid metabolism_Homo sapiens_hsa00561	0.56552388
85	Oocyte meiosis_Homo sapiens_hsa04114	0.56445921
86	Renin secretion_Homo sapiens_hsa04924	0.53678445
87	RNA transport_Homo sapiens_hsa03013	0.49573236
88	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.46387917
89	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.45953023
90	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.45425533
91	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.45256988
92	Calcium signaling pathway_Homo sapiens_hsa04020	0.44465880
93	Fatty acid metabolism_Homo sapiens_hsa01212	0.40061470
94	Caffeine metabolism_Homo sapiens_hsa00232	0.39922848
95	Sulfur metabolism_Homo sapiens_hsa00920	0.38855183
96	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.37800247
97	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.36442724
98	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.34532968
99	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.34112145
100	cAMP signaling pathway_Homo sapiens_hsa04024	0.27766206

ZNF34

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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