ZNF341

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by symbiont of host defense response (GO:0052509)5.26357375
2modulation by symbiont of host defense response (GO:0052031)5.26357375
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.26357375
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.26357375
5positive regulation by organism of defense response of other organism involved in symbiotic interact5.26357375
6modulation by symbiont of host immune response (GO:0052553)5.26357375
7negative regulation of cell killing (GO:0031342)4.36132789
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.36132789
9positive regulation of histone deacetylation (GO:0031065)4.35215320
10DNA deamination (GO:0045006)4.09796140
11cellular extravasation (GO:0045123)4.07703193
12N-acetylneuraminate metabolic process (GO:0006054)3.84553832
13microglial cell activation (GO:0001774)3.81793571
14macrophage activation involved in immune response (GO:0002281)3.72530403
15positive regulation of protein deacetylation (GO:0090312)3.69158450
16NIK/NF-kappaB signaling (GO:0038061)3.67443975
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.67058263
18regulation of interferon-beta biosynthetic process (GO:0045357)3.64726545
19tolerance induction (GO:0002507)3.64036831
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.62593225
21negative regulation of phagocytosis (GO:0050765)3.61791794
22positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.53596797
23response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.51376595
24response to host immune response (GO:0052572)3.51376595
25regulation of MHC class II biosynthetic process (GO:0045346)3.50962900
26regulation of B cell receptor signaling pathway (GO:0050855)3.48095992
27cellular response to interleukin-15 (GO:0071350)3.43573812
28base-excision repair, AP site formation (GO:0006285)3.42190101
29positive regulation of gamma-delta T cell activation (GO:0046645)3.38977550
30regulation of gamma-delta T cell activation (GO:0046643)3.34878029
31peptidyl-histidine modification (GO:0018202)3.29395372
32L-fucose catabolic process (GO:0042355)3.26632931
33fucose catabolic process (GO:0019317)3.26632931
34L-fucose metabolic process (GO:0042354)3.26632931
35response to interleukin-15 (GO:0070672)3.23898098
36neutrophil mediated immunity (GO:0002446)3.21188570
37leukocyte aggregation (GO:0070486)3.14166877
38regulation of gamma-delta T cell differentiation (GO:0045586)3.14099676
39negative regulation of lymphocyte mediated immunity (GO:0002707)3.12909434
40purine deoxyribonucleotide catabolic process (GO:0009155)3.09971285
41regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.07390047
42negative regulation of telomere maintenance (GO:0032205)3.07266732
43opioid receptor signaling pathway (GO:0038003)3.03408972
44regulation of T cell mediated cytotoxicity (GO:0001914)3.01707753
45response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.01023071
46response to host (GO:0075136)3.01023071
47response to host defenses (GO:0052200)3.01023071
48positive regulation of T cell mediated cytotoxicity (GO:0001916)2.99072762
49modulation of growth of symbiont involved in interaction with host (GO:0044144)2.96313029
50regulation of growth of symbiont in host (GO:0044126)2.96313029
51negative regulation of growth of symbiont in host (GO:0044130)2.96313029
52negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.96313029
53negative regulation of interleukin-12 production (GO:0032695)2.94908855
54regulation of chemokine biosynthetic process (GO:0045073)2.93865529
55neutrophil activation (GO:0042119)2.92863523
56negative regulation of execution phase of apoptosis (GO:1900118)2.89918019
57positive regulation of chemokine biosynthetic process (GO:0045080)2.87522648
58myeloid cell activation involved in immune response (GO:0002275)2.86813422
59positive regulation of lymphocyte apoptotic process (GO:0070230)2.85909839
60mast cell activation (GO:0045576)2.81030782
61CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.80315359
62protoporphyrinogen IX biosynthetic process (GO:0006782)2.79767623
63respiratory burst (GO:0045730)2.78356602
64positive regulation of defense response to virus by host (GO:0002230)2.77817915
65regulation of thymocyte apoptotic process (GO:0070243)2.74589412
66negative regulation of T cell mediated immunity (GO:0002710)2.72935068
67regulation of interleukin-6 biosynthetic process (GO:0045408)2.72842729
68positive regulation of interleukin-17 production (GO:0032740)2.71092001
69negative thymic T cell selection (GO:0045060)2.69237414
70response to interferon-beta (GO:0035456)2.68182663
71response to type I interferon (GO:0034340)2.67700467
72positive regulation of toll-like receptor signaling pathway (GO:0034123)2.65997514
73negative regulation of leukocyte mediated immunity (GO:0002704)2.65855631
74leukocyte migration involved in inflammatory response (GO:0002523)2.65575321
75granulocyte activation (GO:0036230)2.65200220
76macrophage activation (GO:0042116)2.64013618
77cellular response to type I interferon (GO:0071357)2.61943462
78type I interferon signaling pathway (GO:0060337)2.61943462
79regulation of B cell apoptotic process (GO:0002902)2.61880406
80antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.61334372
81cellular ketone body metabolic process (GO:0046950)2.61046968
82positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.60957283
83negative T cell selection (GO:0043383)2.60705510
84regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.60322217
85amyloid precursor protein catabolic process (GO:0042987)2.60206423
86myeloid leukocyte mediated immunity (GO:0002444)2.60027394
87leukocyte degranulation (GO:0043299)2.59749923
88negative regulation of interleukin-1 production (GO:0032692)2.58532019
89neutrophil activation involved in immune response (GO:0002283)2.58147170
90germinal center formation (GO:0002467)2.55550698
91positive regulation of T cell apoptotic process (GO:0070234)2.55216066
92mast cell activation involved in immune response (GO:0002279)2.54751722
93mast cell degranulation (GO:0043303)2.54751722
94purinergic nucleotide receptor signaling pathway (GO:0035590)2.54593051
95cellular response to interferon-beta (GO:0035458)2.54247867
96defense response to protozoan (GO:0042832)2.52095583
97regulation of memory T cell differentiation (GO:0043380)2.51550793
98CD4-positive, alpha-beta T cell activation (GO:0035710)2.49520396
99cellular response to exogenous dsRNA (GO:0071360)2.48419470
100positive regulation of leukocyte apoptotic process (GO:2000108)2.48416013

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.85119024
2IRF8_21731497_ChIP-ChIP_J774_Mouse3.05614285
3ZNF274_21170338_ChIP-Seq_K562_Hela3.05573798
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.81848628
5NOTCH1_21737748_ChIP-Seq_TLL_Human2.65428156
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.46350984
7RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.44446934
8LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.42174671
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.37908056
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.37303478
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.20555378
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.15379639
13EBNA2_21746931_ChIP-Seq_IB4-LCL_Human2.10114017
14FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.05468219
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.05178330
16* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.98514504
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.93881338
18MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.93746092
19CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.93029353
20BCL6_27268052_Chip-Seq_Bcells_Human1.92319214
21IKZF1_21737484_ChIP-ChIP_HCT116_Human1.91817663
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.90891707
23* SPI1_23547873_ChIP-Seq_NB4_Human1.90019456
24ELF1_20517297_ChIP-Seq_JURKAT_Human1.85073006
25MAF_26560356_Chip-Seq_TH2_Human1.80425125
26LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.72377773
27YY1_22570637_ChIP-Seq_MALME-3M_Human1.70673212
28E2F1_20622854_ChIP-Seq_HELA_Human1.66790733
29BCOR_27268052_Chip-Seq_Bcells_Human1.65032957
30VDR_21846776_ChIP-Seq_THP-1_Human1.63542578
31MYB_26560356_Chip-Seq_TH2_Human1.62706696
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60260240
33MAF_26560356_Chip-Seq_TH1_Human1.60140052
34GATA3_26560356_Chip-Seq_TH2_Human1.58947781
35STAT4_19710469_ChIP-ChIP_TH1__Mouse1.57269295
36VDR_23849224_ChIP-Seq_CD4+_Human1.54421418
37CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.53726226
38RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.51150087
39RAC3_21632823_ChIP-Seq_H3396_Human1.50138253
40SCL_19346495_ChIP-Seq_HPC-7_Human1.47579005
41MYB_26560356_Chip-Seq_TH1_Human1.45855885
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.44537958
43GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.44249573
44IGF1R_20145208_ChIP-Seq_DFB_Human1.43743052
45FOXP3_21729870_ChIP-Seq_TREG_Human1.43527394
46PHF8_20622854_ChIP-Seq_HELA_Human1.43129863
47GABP_17652178_ChIP-ChIP_JURKAT_Human1.42004342
48ETS1_20019798_ChIP-Seq_JURKAT_Human1.41546445
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.41383369
50SPI1_23127762_ChIP-Seq_K562_Human1.38576488
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.38423789
52NANOG_20526341_ChIP-Seq_ESCs_Human1.37451515
53ERA_21632823_ChIP-Seq_H3396_Human1.37397529
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37184346
55VDR_24763502_ChIP-Seq_THP-1_Human1.36970771
56P68_20966046_ChIP-Seq_HELA_Human1.36848354
57UTX_26944678_Chip-Seq_JUKART_Human1.36351613
58P300_27268052_Chip-Seq_Bcells_Human1.36222876
59CIITA_25753668_ChIP-Seq_RAJI_Human1.34859600
60IRF8_27001747_Chip-Seq_BMDM_Mouse1.34506489
61ETV2_25802403_ChIP-Seq_MESCs_Mouse1.33958931
62GATA3_27048872_Chip-Seq_THYMUS_Human1.30330186
63RUNX_20019798_ChIP-Seq_JUKART_Human1.30057630
64* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29772366
65RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.29115143
66CTCF_20526341_ChIP-Seq_ESCs_Human1.28301196
67EST1_17652178_ChIP-ChIP_JURKAT_Human1.24342151
68PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20482264
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20455395
70OCT4_20526341_ChIP-Seq_ESCs_Human1.20336297
71SA1_27219007_Chip-Seq_Bcells_Human1.20187464
72CTCF_26484167_Chip-Seq_Bcells_Mouse1.19518194
73VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19359381
74NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.18182442
75MYC_22102868_ChIP-Seq_BL_Human1.17927275
76CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17419185
77TP53_22573176_ChIP-Seq_HFKS_Human1.17315094
78GATA3_21878914_ChIP-Seq_MCF-7_Human1.16589958
79STAT1_20625510_ChIP-Seq_HELA_Human1.14411654
80* GABP_19822575_ChIP-Seq_HepG2_Human1.13271258
81SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.12409145
82CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11919504
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11856443
84SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10396054
85TAF2_19829295_ChIP-Seq_ESCs_Human1.10368129
86SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.09873219
87KDM5A_27292631_Chip-Seq_BREAST_Human1.08754461
88VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07604725
89P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.07217510
90STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05321093
91GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03640166
92RARB_24833708_ChIP-Seq_LIVER_Mouse1.02713752
93SMC4_20622854_ChIP-Seq_HELA_Human1.01132289
94ER_23166858_ChIP-Seq_MCF-7_Human1.00345799
95PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99503490
96LXR_22292898_ChIP-Seq_THP-1_Human0.98732724
97VDR_22108803_ChIP-Seq_LS180_Human0.98117892
98EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.95875589
99PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95819662
100PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.95395146

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.52960445
2MP0003436_decreased_susceptibility_to3.25138072
3MP0001790_abnormal_immune_system2.87544919
4MP0005387_immune_system_phenotype2.87544919
5MP0005083_abnormal_biliary_tract2.81866488
6MP0001835_abnormal_antigen_presentation2.80923124
7MP0005671_abnormal_response_to2.70184200
8MP0001800_abnormal_humoral_immune2.58597986
9MP0009785_altered_susceptibility_to2.57881821
10MP0000685_abnormal_immune_system2.51207548
11MP0005000_abnormal_immune_tolerance2.46351243
12MP0002148_abnormal_hypersensitivity_rea2.40178540
13MP0002277_abnormal_respiratory_mucosa2.36950913
14MP0002723_abnormal_immune_serum2.32195065
15MP0005025_abnormal_response_to2.26470135
16MP0002419_abnormal_innate_immunity2.25784086
17MP0002452_abnormal_antigen_presenting2.14618966
18MP0005310_abnormal_salivary_gland2.13220725
19MP0002420_abnormal_adaptive_immunity2.12318016
20MP0001819_abnormal_immune_cell2.11803816
21MP0001986_abnormal_taste_sensitivity2.03648768
22MP0003763_abnormal_thymus_physiology1.99547136
23MP0008875_abnormal_xenobiotic_pharmacok1.98943081
24MP0001873_stomach_inflammation1.97014668
25MP0002254_reproductive_system_inflammat1.82080287
26MP0002405_respiratory_system_inflammati1.76925033
27MP0009333_abnormal_splenocyte_physiolog1.74723985
28MP0003646_muscle_fatigue1.74674677
29MP0001968_abnormal_touch/_nociception1.72300137
30MP0009764_decreased_sensitivity_to1.65733216
31MP0002138_abnormal_hepatobiliary_system1.64998463
32MP0003195_calcinosis1.63792384
33MP0003303_peritoneal_inflammation1.60573659
34MP0001845_abnormal_inflammatory_respons1.57826864
35MP0005451_abnormal_body_composition1.56804900
36MP0005365_abnormal_bile_salt1.53510007
37MP0005085_abnormal_gallbladder_physiolo1.52935332
38MP0010155_abnormal_intestine_physiology1.50414493
39MP0008872_abnormal_physiological_respon1.47976978
40MP0001501_abnormal_sleep_pattern1.47829296
41MP0001533_abnormal_skeleton_physiology1.47685855
42MP0000716_abnormal_immune_system1.46041064
43MP0008877_abnormal_DNA_methylation1.45927897
44MP0006082_CNS_inflammation1.45673474
45MP0005075_abnormal_melanosome_morpholog1.43647277
46MP0003806_abnormal_nucleotide_metabolis1.40019692
47MP0003866_abnormal_defecation1.34879215
48MP0002398_abnormal_bone_marrow1.34166454
49MP0000689_abnormal_spleen_morphology1.33024962
50MP0000015_abnormal_ear_pigmentation1.31506704
51MP0008961_abnormal_basal_metabolism1.28468495
52MP0001529_abnormal_vocalization1.23142728
53MP0002722_abnormal_immune_system1.21854424
54MP0003252_abnormal_bile_duct1.21681062
55MP0008469_abnormal_protein_level1.19300777
56MP0008260_abnormal_autophagy1.17818716
57MP0002736_abnormal_nociception_after1.15112040
58MP0006035_abnormal_mitochondrial_morpho1.13276225
59MP0004381_abnormal_hair_follicle1.10436236
60MP0002429_abnormal_blood_cell1.07483908
61MP0003045_fibrosis1.07255100
62MP0004947_skin_inflammation1.06095189
63MP0001919_abnormal_reproductive_system1.03347339
64MP0000703_abnormal_thymus_morphology0.98371976
65MP0002928_abnormal_bile_duct0.92073347
66MP0002933_joint_inflammation0.91018210
67MP0001764_abnormal_homeostasis0.90807238
68MP0003172_abnormal_lysosome_physiology0.87705544
69MP0005464_abnormal_platelet_physiology0.87571678
70MP0002693_abnormal_pancreas_physiology0.87262597
71MP0002332_abnormal_exercise_endurance0.86460116
72MP0004145_abnormal_muscle_electrophysio0.85014903
73MP0005084_abnormal_gallbladder_morpholo0.83902492
74MP0005174_abnormal_tail_pigmentation0.83240508
75MP0005551_abnormal_eye_electrophysiolog0.82801318
76MP0002132_abnormal_respiratory_system0.82223504
77MP0003183_abnormal_peptide_metabolism0.81883827
78MP0002876_abnormal_thyroid_physiology0.81720452
79MP0006036_abnormal_mitochondrial_physio0.79958528
80MP0002163_abnormal_gland_morphology0.79549798
81MP0004142_abnormal_muscle_tone0.76223798
82MP0008058_abnormal_DNA_repair0.75881167
83MP0001663_abnormal_digestive_system0.74965228
84MP0005266_abnormal_metabolism0.73962316
85MP0008874_decreased_physiological_sensi0.72600840
86MP0005646_abnormal_pituitary_gland0.72528468
87MP0002822_catalepsy0.69889087
88MP0000372_irregular_coat_pigmentation0.68200266
89MP0004043_abnormal_pH_regulation0.67581510
90MP0010329_abnormal_lipoprotein_level0.67407113
91MP0004133_heterotaxia0.66905610
92MP0000427_abnormal_hair_cycle0.65931170
93MP0005670_abnormal_white_adipose0.65779040
94MP0003075_altered_response_to0.64827655
95MP0005645_abnormal_hypothalamus_physiol0.63885098
96MP0003786_premature_aging0.63692084
97MP0009745_abnormal_behavioral_response0.60057568
98MP0002095_abnormal_skin_pigmentation0.57811041
99MP0003787_abnormal_imprinting0.57118438
100MP0001270_distended_abdomen0.56533638

Predicted human phenotypes

RankGene SetZ-score
1Myositis (HP:0100614)4.21082989
2Recurrent bacterial skin infections (HP:0005406)4.10060223
3Stomatitis (HP:0010280)4.02952263
4Optic neuritis (HP:0100653)3.84353204
5Retrobulbar optic neuritis (HP:0100654)3.84353204
6Orchitis (HP:0100796)3.73843491
7Elevated erythrocyte sedimentation rate (HP:0003565)3.71627152
8Recurrent abscess formation (HP:0002722)3.65128330
9Increased neuronal autofluorescent lipopigment (HP:0002074)3.53574139
10Chronic mucocutaneous candidiasis (HP:0002728)3.37128562
11Recurrent cutaneous fungal infections (HP:0011370)3.37128562
12Abnormal delayed hypersensitivity skin test (HP:0002963)3.29605984
13Congenital stationary night blindness (HP:0007642)3.26961809
14Recurrent fungal infections (HP:0002841)3.22540868
15Keratoconjunctivitis (HP:0001096)3.10066771
16Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.09915831
17Recurrent skin infections (HP:0001581)3.09843726
18Progressive microcephaly (HP:0000253)3.06809694
19Tetany (HP:0001281)3.05631451
20Increased cerebral lipofuscin (HP:0011813)3.03145367
21Absent rod-and cone-mediated responses on ERG (HP:0007688)3.01125758
22Eczematoid dermatitis (HP:0000976)2.89404413
23Encephalitis (HP:0002383)2.85191560
24Clumsiness (HP:0002312)2.84934598
25Abnormal rod and cone electroretinograms (HP:0008323)2.84123287
26Keratoconjunctivitis sicca (HP:0001097)2.76892904
27Cheilitis (HP:0100825)2.72207824
28Visual hallucinations (HP:0002367)2.70821484
29Abnormality of T cell physiology (HP:0011840)2.69072755
30Tubular atrophy (HP:0000092)2.68391871
31Pustule (HP:0200039)2.65143508
32Abnormality of macrophages (HP:0004311)2.60470913
33Hypochromic anemia (HP:0001931)2.55714798
34Hemoptysis (HP:0002105)2.53112668
35Pendular nystagmus (HP:0012043)2.51232109
36Gastrointestinal infarctions (HP:0005244)2.50497796
37Panhypogammaglobulinemia (HP:0003139)2.47476186
38Episodic fever (HP:0001954)2.43244101
39Meningitis (HP:0001287)2.42125671
40Attenuation of retinal blood vessels (HP:0007843)2.39347608
41IgG deficiency (HP:0004315)2.29447128
42Vasculitis (HP:0002633)2.29441844
43Anorexia (HP:0002039)2.26254857
44Parakeratosis (HP:0001036)2.26224113
45Stomach cancer (HP:0012126)2.25600486
46Abnormality of the renal cortex (HP:0011035)2.22980759
47Nephronophthisis (HP:0000090)2.22618915
48Concave nail (HP:0001598)2.19260547
49Abnormality of T cells (HP:0002843)2.18150254
50Obstructive lung disease (HP:0006536)2.16843740
51Chronic obstructive pulmonary disease (HP:0006510)2.16843740
52Recurrent gram-negative bacterial infections (HP:0005420)2.13360215
53Chest pain (HP:0100749)2.13337392
54Pulmonary infiltrates (HP:0002113)2.13136204
55Inability to walk (HP:0002540)2.12686967
56Severe visual impairment (HP:0001141)2.12300317
57Polydipsia (HP:0001959)2.11488369
58Abnormal drinking behavior (HP:0030082)2.11488369
59Progressive inability to walk (HP:0002505)2.06247238
60Mediastinal lymphadenopathy (HP:0100721)2.06170044
61Abnormality of transition element cation homeostasis (HP:0011030)2.05154716
623-Methylglutaconic aciduria (HP:0003535)2.04393573
63Prostate neoplasm (HP:0100787)2.03682905
64Pancreatic cysts (HP:0001737)2.01701445
65Decreased electroretinogram (ERG) amplitude (HP:0000654)2.01598847
66Opisthotonus (HP:0002179)1.99003165
67Hyperventilation (HP:0002883)1.98988070
68Increased IgM level (HP:0003496)1.96183338
69Type II lissencephaly (HP:0007260)1.96034782
70Lissencephaly (HP:0001339)1.94251230
71Hypochromic microcytic anemia (HP:0004840)1.92719743
72Abnormality of the pleura (HP:0002103)1.92368985
73Severe muscular hypotonia (HP:0006829)1.90934099
74Petechiae (HP:0000967)1.88496082
75Keratitis (HP:0000491)1.88398672
76Acute hepatic failure (HP:0006554)1.88299110
77Microretrognathia (HP:0000308)1.88080447
78Hypoplasia of the uterus (HP:0000013)1.87887281
79Abnormality of the renal medulla (HP:0100957)1.85247524
80Abnormality of the prostate (HP:0008775)1.84340991
81Decreased central vision (HP:0007663)1.83883007
82Ketosis (HP:0001946)1.82986550
83Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.82254979
84Gangrene (HP:0100758)1.81653361
85Vacuolated lymphocytes (HP:0001922)1.80411125
86Hypothermia (HP:0002045)1.78861271
87Ketoacidosis (HP:0001993)1.78164947
88Amelogenesis imperfecta (HP:0000705)1.76251127
89Abnormality of the endocardium (HP:0004306)1.76232864
90Abnormality of iron homeostasis (HP:0011031)1.76038575
91Chronic otitis media (HP:0000389)1.75576934
92Aplasia/hypoplasia of the uterus (HP:0008684)1.73443382
93Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.72321204
94Cerebellar dysplasia (HP:0007033)1.72191354
95Polyuria (HP:0000103)1.70482073
96Intellectual disability, progressive (HP:0006887)1.69322486
97Premature loss of primary teeth (HP:0006323)1.68565228
98Autoimmune thrombocytopenia (HP:0001973)1.68368212
99Brushfield spots (HP:0001088)1.66599404
100Increased CSF lactate (HP:0002490)1.64948540

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.59781884
2PINK13.49563276
3RIPK42.98130154
4TNK22.85916871
5IRAK42.46935099
6ERN12.34837674
7TAOK12.26248996
8BCKDK2.23946327
9TLK12.23686082
10FRK2.22018446
11TXK2.11941731
12ADRBK22.07753168
13CAMKK22.00437945
14EPHB11.99568301
15SMG11.96884165
16NUAK11.83366087
17CCNB11.74918138
18BLK1.69036542
19IKBKE1.65031675
20MAP3K111.63999127
21GRK61.61449133
22VRK21.56988307
23TAF11.53078509
24MUSK1.50952837
25TESK21.50942408
26WNK41.45406795
27ZAP701.45179623
28IKBKB1.42939870
29SYK1.42623494
30JAK31.41368585
31SIK31.36963868
32NEK21.35854356
33CSK1.30589245
34FES1.28441790
35TYK21.27485894
36MAP2K31.26652751
37CHUK1.14440530
38ZAK1.10080513
39BTK1.06832245
40INSRR1.06489108
41PRKCQ1.06449379
42PRKD21.04409109
43MAP4K21.01736231
44CSF1R0.97283373
45DAPK20.97085120
46MAP3K60.94032142
47MAP2K60.93521070
48HCK0.92364834
49LYN0.89163918
50IRAK30.87553406
51MAPKAPK30.86339675
52GRK10.86141709
53HIPK20.82954711
54FGR0.82367345
55WNK30.81318835
56ITK0.81020087
57LCK0.80816478
58MAP2K20.79252054
59ACVR1B0.77518591
60PRKCI0.76777486
61CAMKK10.76390731
62PHKG10.74185024
63PHKG20.74185024
64MAPK130.74085378
65TBK10.72083315
66CSNK1G30.70108047
67MAP3K70.69990339
68TRIM280.67873484
69IRAK10.66019526
70MARK30.63731446
71MAP3K140.61814379
72PRKAA20.61447717
73MAP3K30.61310150
74TAOK20.61038724
75NME10.58279535
76STK110.56552225
77LRRK20.56312897
78CSNK1G20.54106521
79TRIB30.52665538
80PTK2B0.52593775
81MARK20.51669771
82PRKCZ0.49403431
83PRKG20.49306754
84RPS6KA60.48848499
85CAMK1D0.45164801
86TAOK30.43997397
87ADRBK10.43700110
88MAP2K40.43136754
89CAMK10.41687942
90PRKD30.41161748
91TEC0.40093615
92MATK0.38854204
93RPS6KA40.38480497
94MAP2K70.38317266
95JAK20.38113895
96CSNK1A1L0.37762157
97DAPK10.37561041
98PASK0.37093491
99KIT0.36725069
100DYRK20.35291655

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.82085345
2Intestinal immune network for IgA production_Homo sapiens_hsa046722.68100446
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.64044772
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.32762249
5Allograft rejection_Homo sapiens_hsa053302.24332940
6Regulation of autophagy_Homo sapiens_hsa041402.23788702
7Autoimmune thyroid disease_Homo sapiens_hsa053201.99882009
8Graft-versus-host disease_Homo sapiens_hsa053321.98932094
9Type I diabetes mellitus_Homo sapiens_hsa049401.89752310
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.84785546
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.79195809
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.72768496
13Phototransduction_Homo sapiens_hsa047441.68970249
14NOD-like receptor signaling pathway_Homo sapiens_hsa046211.66233348
15Leishmaniasis_Homo sapiens_hsa051401.65421396
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.63012186
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.62913581
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.62565180
19Osteoclast differentiation_Homo sapiens_hsa043801.61178483
20Linoleic acid metabolism_Homo sapiens_hsa005911.59380228
21Tuberculosis_Homo sapiens_hsa051521.55779028
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.55745483
23Ether lipid metabolism_Homo sapiens_hsa005651.54977603
24Staphylococcus aureus infection_Homo sapiens_hsa051501.51051241
25T cell receptor signaling pathway_Homo sapiens_hsa046601.48421716
26Butanoate metabolism_Homo sapiens_hsa006501.45836297
27African trypanosomiasis_Homo sapiens_hsa051431.45332836
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.44228259
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44181059
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.39789623
31Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.39686577
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.37615129
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31926466
34Collecting duct acid secretion_Homo sapiens_hsa049661.30011996
35Sulfur relay system_Homo sapiens_hsa041221.28289850
36Basal transcription factors_Homo sapiens_hsa030221.28130365
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.27413230
38Measles_Homo sapiens_hsa051621.26013319
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.25323308
40Selenocompound metabolism_Homo sapiens_hsa004501.20879823
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.17946243
42Hematopoietic cell lineage_Homo sapiens_hsa046401.16100063
43Caffeine metabolism_Homo sapiens_hsa002321.16065332
44B cell receptor signaling pathway_Homo sapiens_hsa046621.13511556
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.13398923
46Base excision repair_Homo sapiens_hsa034101.13125481
47Oxidative phosphorylation_Homo sapiens_hsa001901.12216977
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.12181870
49Legionellosis_Homo sapiens_hsa051341.11987254
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.11276632
51Asthma_Homo sapiens_hsa053101.11075349
52Arachidonic acid metabolism_Homo sapiens_hsa005901.07461190
53Herpes simplex infection_Homo sapiens_hsa051681.04100370
54Rheumatoid arthritis_Homo sapiens_hsa053231.03298600
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03032037
56Glycerophospholipid metabolism_Homo sapiens_hsa005641.01668566
57Phagosome_Homo sapiens_hsa041451.01632768
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00903364
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.99382159
60Homologous recombination_Homo sapiens_hsa034400.96468994
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96175384
62Lysosome_Homo sapiens_hsa041420.94606913
63Chemokine signaling pathway_Homo sapiens_hsa040620.94312403
64TNF signaling pathway_Homo sapiens_hsa046680.90539831
65Malaria_Homo sapiens_hsa051440.88853556
66Influenza A_Homo sapiens_hsa051640.83736788
67Ovarian steroidogenesis_Homo sapiens_hsa049130.83584859
68Nitrogen metabolism_Homo sapiens_hsa009100.80408765
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77974269
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76778875
71ABC transporters_Homo sapiens_hsa020100.75867204
72Sulfur metabolism_Homo sapiens_hsa009200.72900444
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70616940
74Parkinsons disease_Homo sapiens_hsa050120.70558434
75Hepatitis C_Homo sapiens_hsa051600.69391294
76Antigen processing and presentation_Homo sapiens_hsa046120.68940948
77Acute myeloid leukemia_Homo sapiens_hsa052210.68738575
78RNA polymerase_Homo sapiens_hsa030200.62702684
79Peroxisome_Homo sapiens_hsa041460.57669676
80Glycerolipid metabolism_Homo sapiens_hsa005610.56130658
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55024901
82Toxoplasmosis_Homo sapiens_hsa051450.53431662
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51881623
84Notch signaling pathway_Homo sapiens_hsa043300.48474735
85Apoptosis_Homo sapiens_hsa042100.48201786
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45821078
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.44704555
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.42764605
89Fanconi anemia pathway_Homo sapiens_hsa034600.40586592
90Epstein-Barr virus infection_Homo sapiens_hsa051690.40460702
91Hepatitis B_Homo sapiens_hsa051610.39807905
92Taste transduction_Homo sapiens_hsa047420.39692469
93One carbon pool by folate_Homo sapiens_hsa006700.39444327
94Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.37383374
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37133015
96Proteasome_Homo sapiens_hsa030500.36693232
97Morphine addiction_Homo sapiens_hsa050320.35311669
98Metabolic pathways_Homo sapiens_hsa011000.33285444
99Viral myocarditis_Homo sapiens_hsa054160.32268924
100RNA degradation_Homo sapiens_hsa030180.31677998

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