ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	seminiferous tubule development (GO:0072520)	4.96502288
2	hindbrain development (GO:0030902)	4.80413581
3	regulation of hippo signaling (GO:0035330)	4.54452803
4	response to pheromone (GO:0019236)	4.41176816
5	replication fork processing (GO:0031297)	4.12583049
6	monoubiquitinated protein deubiquitination (GO:0035520)	4.04842718
7	transcription elongation from RNA polymerase I promoter (GO:0006362)	3.99780462
8	snRNA transcription (GO:0009301)	3.97331845
9	regulation of RNA export from nucleus (GO:0046831)	3.88411696
10	single strand break repair (GO:0000012)	3.74841868
11	protein K6-linked ubiquitination (GO:0085020)	3.73690278
12	termination of RNA polymerase I transcription (GO:0006363)	3.71310297
13	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.57401817
14	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.57401817
15	regulation of translation, ncRNA-mediated (GO:0045974)	3.57401817
16	cilium or flagellum-dependent cell motility (GO:0001539)	3.44901327
17	uterus development (GO:0060065)	3.40294776
18	nonmotile primary cilium assembly (GO:0035058)	3.36126964
19	ribonucleoprotein complex disassembly (GO:0032988)	3.32553623
20	cornea development in camera-type eye (GO:0061303)	3.31098551
21	transcription initiation from RNA polymerase I promoter (GO:0006361)	3.31023355
22	protein localization to synapse (GO:0035418)	3.24892570
23	behavioral response to nicotine (GO:0035095)	3.24305893
24	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.18985682
25	cellular response to ATP (GO:0071318)	3.15323362
26	regulation of bile acid biosynthetic process (GO:0070857)	3.10612616
27	regulation of nucleobase-containing compound transport (GO:0032239)	3.09122470
28	spinal cord development (GO:0021510)	3.06802044
29	neural tube formation (GO:0001841)	3.05163326
30	axonemal dynein complex assembly (GO:0070286)	3.03701244
31	positive regulation of mitochondrial fission (GO:0090141)	3.03649111
32	nuclear pore complex assembly (GO:0051292)	3.00200684
33	intestinal cholesterol absorption (GO:0030299)	2.99914659
34	regulation of hexokinase activity (GO:1903299)	2.96395032
35	regulation of glucokinase activity (GO:0033131)	2.96395032
36	translesion synthesis (GO:0019985)	2.95444015
37	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.93081666
38	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.92479797
39	presynaptic membrane assembly (GO:0097105)	2.88703433
40	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.86941060
41	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.86941060
42	sympathetic nervous system development (GO:0048485)	2.86587840
43	methionine biosynthetic process (GO:0009086)	2.84522019
44	chemosensory behavior (GO:0007635)	2.83844001
45	nuclear pore organization (GO:0006999)	2.83716589
46	organelle disassembly (GO:1903008)	2.80138175
47	neuronal action potential propagation (GO:0019227)	2.79122725
48	DNA methylation involved in gamete generation (GO:0043046)	2.75945888
49	DNA double-strand break processing (GO:0000729)	2.75331041
50	multicellular organism reproduction (GO:0032504)	2.75042668
51	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	2.73860776
52	protein import into peroxisome matrix (GO:0016558)	2.72723003
53	L-methionine salvage (GO:0071267)	2.70373281
54	L-methionine biosynthetic process (GO:0071265)	2.70373281
55	amino acid salvage (GO:0043102)	2.70373281
56	mitochondrial RNA metabolic process (GO:0000959)	2.69573931
57	regulation of DNA endoreduplication (GO:0032875)	2.68368061
58	rRNA transcription (GO:0009303)	2.68269927
59	piRNA metabolic process (GO:0034587)	2.68084521
60	viral mRNA export from host cell nucleus (GO:0046784)	2.66484018
61	postreplication repair (GO:0006301)	2.64595661
62	neurotransmitter-gated ion channel clustering (GO:0072578)	2.58110979
63	regulation of protein polyubiquitination (GO:1902914)	2.54235691
64	meiotic chromosome segregation (GO:0045132)	2.51871483
65	indolalkylamine catabolic process (GO:0046218)	2.51617227
66	tryptophan catabolic process (GO:0006569)	2.51617227
67	indole-containing compound catabolic process (GO:0042436)	2.51617227
68	gene silencing by RNA (GO:0031047)	2.51425428
69	heparin biosynthetic process (GO:0030210)	2.50491609
70	heparin metabolic process (GO:0030202)	2.50491609
71	substrate-independent telencephalic tangential migration (GO:0021826)	2.49054545
72	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.49054545
73	tongue development (GO:0043586)	2.48837984
74	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	2.48110513
75	C4-dicarboxylate transport (GO:0015740)	2.47797290
76	very-low-density lipoprotein particle assembly (GO:0034379)	2.47598155
77	startle response (GO:0001964)	2.44659583
78	interkinetic nuclear migration (GO:0022027)	2.44080831
79	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.40354512
80	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	2.40261859
81	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.40261859
82	positive regulation of mitotic sister chromatid separation (GO:1901970)	2.40261859
83	microtubule anchoring (GO:0034453)	2.40134656
84	primary amino compound metabolic process (GO:1901160)	2.38898204
85	aspartate family amino acid biosynthetic process (GO:0009067)	2.38746323
86	protein polyglutamylation (GO:0018095)	2.37686565
87	limb bud formation (GO:0060174)	2.37193983
88	presynaptic membrane organization (GO:0097090)	2.36506789
89	transcription from RNA polymerase I promoter (GO:0006360)	2.34912492
90	methionine metabolic process (GO:0006555)	2.34881904
91	reciprocal DNA recombination (GO:0035825)	2.34811029
92	reciprocal meiotic recombination (GO:0007131)	2.34811029
93	peripheral nervous system neuron development (GO:0048935)	2.34228135
94	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	2.32917225
95	zinc ion homeostasis (GO:0055069)	2.31883139
96	glycerophospholipid catabolic process (GO:0046475)	2.30487028
97	regulation of centriole replication (GO:0046599)	2.30473253
98	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.30470204
99	DNA methylation (GO:0006306)	2.24890014
100	DNA alkylation (GO:0006305)	2.24890014

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	4.40147917
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.84619522
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.42884732
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.30443754
5	EZH2_22144423_ChIP-Seq_EOC_Human	3.12737898
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.94140727
7	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.91128184
8	* GABP_17652178_ChIP-ChIP_JURKAT_Human	2.76706508
9	E2F7_22180533_ChIP-Seq_HELA_Human	2.68936049
10	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.64045962
11	* EST1_17652178_ChIP-ChIP_JURKAT_Human	2.57338237
12	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.50479512
13	IGF1R_20145208_ChIP-Seq_DFB_Human	2.48321913
14	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.47379714
15	GBX2_23144817_ChIP-Seq_PC3_Human	2.40360042
16	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.40311452
17	* ETS1_20019798_ChIP-Seq_JURKAT_Human	2.31102178
18	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.29886070
19	IRF1_19129219_ChIP-ChIP_H3396_Human	2.25780991
20	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.20250166
21	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.17666993
22	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.13797334
23	ELK1_19687146_ChIP-ChIP_HELA_Human	2.06119287
24	GABP_19822575_ChIP-Seq_HepG2_Human	2.05563592
25	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.03898680
26	EWS_26573619_Chip-Seq_HEK293_Human	2.02576136
27	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.94276248
28	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.87964266
29	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.82223422
30	TAF15_26573619_Chip-Seq_HEK293_Human	1.77947229
31	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.75766420
32	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.74678322
33	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.74612292
34	TP53_16413492_ChIP-PET_HCT116_Human	1.71956698
35	FUS_26573619_Chip-Seq_HEK293_Human	1.71587676
36	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.70333993
37	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.68314806
38	VDR_23849224_ChIP-Seq_CD4+_Human	1.64291785
39	VDR_22108803_ChIP-Seq_LS180_Human	1.59264980
40	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.58061937
41	* MYC_18940864_ChIP-ChIP_HL60_Human	1.55268706
42	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.55046619
43	KDM5A_27292631_Chip-Seq_BREAST_Human	1.53806424
44	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.51658250
45	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.49687350
46	STAT3_23295773_ChIP-Seq_U87_Human	1.47108019
47	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.46420233
48	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.45538570
49	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.44041406
50	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	1.43760893
51	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.39575248
52	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.38216954
53	FOXP3_21729870_ChIP-Seq_TREG_Human	1.35567765
54	CIITA_25753668_ChIP-Seq_RAJI_Human	1.33906044
55	DCP1A_22483619_ChIP-Seq_HELA_Human	1.32734829
56	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.26571851
57	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.25026746
58	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.25003141
59	AR_21572438_ChIP-Seq_LNCaP_Human	1.21789278
60	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.21731328
61	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.21624493
62	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.18517531
63	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.18190422
64	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.17974646
65	TCF4_23295773_ChIP-Seq_U87_Human	1.15333055
66	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.13833539
67	SMAD4_21799915_ChIP-Seq_A2780_Human	1.12686140
68	AR_25329375_ChIP-Seq_VCAP_Human	1.12625602
69	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.11803636
70	P300_19829295_ChIP-Seq_ESCs_Human	1.11476949
71	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.10287803
72	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.05448028
73	ER_23166858_ChIP-Seq_MCF-7_Human	1.05391456
74	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.05040580
75	* HNF4A_19822575_ChIP-Seq_HepG2_Human	1.00088302
76	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.99568353
77	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.97366437
78	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.97062467
79	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.96919173
80	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96644058
81	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.95741164
82	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.95477852
83	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.95220245
84	JUN_21703547_ChIP-Seq_K562_Human	0.94294682
85	TTF2_22483619_ChIP-Seq_HELA_Human	0.93520588
86	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.93381226
87	CBP_20019798_ChIP-Seq_JUKART_Human	0.93381226
88	HOXB7_26014856_ChIP-Seq_BT474_Human	0.92825404
89	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.92561882
90	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.91284823
91	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.91044592
92	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.89394339
93	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.87614357
94	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.86373726
95	TP53_22573176_ChIP-Seq_HFKS_Human	0.82950245
96	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.82937187
97	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.81672159
98	RNF2_27304074_Chip-Seq_NSC_Mouse	0.81106008
99	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.80664888
100	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.78672149

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001986_abnormal_taste_sensitivity	4.27450311
2	MP0003123_paternal_imprinting	3.52850622
3	MP0003121_genomic_imprinting	2.97912326
4	MP0005187_abnormal_penis_morphology	2.87376257
5	MP0003122_maternal_imprinting	2.80469004
6	MP0003315_abnormal_perineum_morphology	2.68717361
7	MP0003646_muscle_fatigue	2.51065627
8	MP0000427_abnormal_hair_cycle	2.16750068
9	MP0005451_abnormal_body_composition	2.15382532
10	MP0005408_hypopigmentation	2.11205585
11	MP0002160_abnormal_reproductive_system	2.10825657
12	MP0008058_abnormal_DNA_repair	1.99693225
13	MP0001661_extended_life_span	1.98971349
14	MP0004145_abnormal_muscle_electrophysio	1.97852451
15	MP0003890_abnormal_embryonic-extraembry	1.93894078
16	MP0003868_abnormal_feces_composition	1.89371064
17	MP0008789_abnormal_olfactory_epithelium	1.82156224
18	MP0003195_calcinosis	1.80511592
19	MP0009697_abnormal_copulation	1.76275998
20	MP0005645_abnormal_hypothalamus_physiol	1.74906841
21	MP0005389_reproductive_system_phenotype	1.73919708
22	MP0003111_abnormal_nucleus_morphology	1.71650961
23	MP0001984_abnormal_olfaction	1.67410046
24	MP0008775_abnormal_heart_ventricle	1.63119222
25	MP0008057_abnormal_DNA_replication	1.60242387
26	MP0002837_dystrophic_cardiac_calcinosis	1.54931176
27	MP0003787_abnormal_imprinting	1.52392248
28	MP0006035_abnormal_mitochondrial_morpho	1.49051476
29	MP0002735_abnormal_chemical_nociception	1.46546185
30	MP0000372_irregular_coat_pigmentation	1.46025300
31	MP0001666_abnormal_nutrient_absorption	1.44736469
32	MP0008995_early_reproductive_senescence	1.40058314
33	MP0005551_abnormal_eye_electrophysiolog	1.35831455
34	MP0000647_abnormal_sebaceous_gland	1.35511614
35	MP0008961_abnormal_basal_metabolism	1.35294342
36	MP0002089_abnormal_postnatal_growth/wei	1.35060071
37	MP0001968_abnormal_touch/_nociception	1.34759565
38	MP0005394_taste/olfaction_phenotype	1.31041488
39	MP0005499_abnormal_olfactory_system	1.31041488
40	MP0004233_abnormal_muscle_weight	1.30444347
41	MP0002938_white_spotting	1.29942790
42	MP0002102_abnormal_ear_morphology	1.28752271
43	MP0001919_abnormal_reproductive_system	1.28028368
44	MP0005220_abnormal_exocrine_pancreas	1.22333628
45	MP0010094_abnormal_chromosome_stability	1.21556667
46	MP0000569_abnormal_digit_pigmentation	1.21523352
47	MP0004133_heterotaxia	1.19283641
48	MP0004924_abnormal_behavior	1.19255072
49	MP0005386_behavior/neurological_phenoty	1.19255072
50	MP0002233_abnormal_nose_morphology	1.13293390
51	MP0002876_abnormal_thyroid_physiology	1.12400338
52	MP0003786_premature_aging	1.09850145
53	MP0008875_abnormal_xenobiotic_pharmacok	1.09814894
54	MP0010329_abnormal_lipoprotein_level	1.08775119
55	MP0003119_abnormal_digestive_system	1.06918473
56	MP0002210_abnormal_sex_determination	1.06654137
57	MP0001270_distended_abdomen	1.05172856
58	MP0002557_abnormal_social/conspecific_i	1.03899015
59	MP0001324_abnormal_eye_pigmentation	1.02158675
60	MP0004134_abnormal_chest_morphology	1.01278323
61	MP0003950_abnormal_plasma_membrane	1.01244142
62	MP0002184_abnormal_innervation	0.99833691
63	MP0001929_abnormal_gametogenesis	0.99035761
64	MP0000358_abnormal_cell_content/	0.97444658
65	MP0005195_abnormal_posterior_eye	0.96385013
66	MP0003755_abnormal_palate_morphology	0.96285067
67	MP0006292_abnormal_olfactory_placode	0.95793301
68	MP0006072_abnormal_retinal_apoptosis	0.94962946
69	MP0005647_abnormal_sex_gland	0.94950629
70	MP0001944_abnormal_pancreas_morphology	0.94544473
71	MP0003385_abnormal_body_wall	0.94516260
72	MP0000003_abnormal_adipose_tissue	0.93400085
73	MP0003943_abnormal_hepatobiliary_system	0.92510754
74	MP0002928_abnormal_bile_duct	0.92505418
75	MP0002638_abnormal_pupillary_reflex	0.90379299
76	MP0003698_abnormal_male_reproductive	0.90261732
77	MP0003693_abnormal_embryo_hatching	0.89419288
78	MP0003937_abnormal_limbs/digits/tail_de	0.86504739
79	MP0009250_abnormal_appendicular_skeleto	0.86408493
80	MP0000639_abnormal_adrenal_gland	0.86271258
81	MP0004185_abnormal_adipocyte_glucose	0.86196477
82	MP0001299_abnormal_eye_distance/	0.85339833
83	MP0009046_muscle_twitch	0.84189790
84	MP0000538_abnormal_urinary_bladder	0.81277872
85	MP0000778_abnormal_nervous_system	0.80686436
86	MP0003252_abnormal_bile_duct	0.80154940
87	MP0002234_abnormal_pharynx_morphology	0.78390806
88	MP0001145_abnormal_male_reproductive	0.76078443
89	MP0005334_abnormal_fat_pad	0.74549101
90	MP0000653_abnormal_sex_gland	0.74543575
91	MP0004043_abnormal_pH_regulation	0.73560298
92	MP0002282_abnormal_trachea_morphology	0.73339595
93	MP0003221_abnormal_cardiomyocyte_apopto	0.73328445
94	MP0005253_abnormal_eye_physiology	0.72797178
95	MP0002752_abnormal_somatic_nervous	0.72704909
96	MP0006054_spinal_hemorrhage	0.72299072
97	MP0002751_abnormal_autonomic_nervous	0.72134252
98	MP0004742_abnormal_vestibular_system	0.72078867
99	MP0002095_abnormal_skin_pigmentation	0.71259848
100	MP0003942_abnormal_urinary_system	0.71120275

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Cutaneous melanoma (HP:0012056)	4.60984498
2	Hyperventilation (HP:0002883)	4.11780332
3	Protruding tongue (HP:0010808)	3.88827665
4	Renal cortical cysts (HP:0000803)	3.72444961
5	Exotropia (HP:0000577)	3.71291535
6	Broad-based gait (HP:0002136)	3.32049102
7	Drooling (HP:0002307)	3.21114375
8	Abnormality of midbrain morphology (HP:0002418)	3.04562881
9	Molar tooth sign on MRI (HP:0002419)	3.04562881
10	Enlarged penis (HP:0000040)	3.02838688
11	Macroorchidism (HP:0000053)	3.02476125
12	Medial flaring of the eyebrow (HP:0010747)	2.98266996
13	Nephronophthisis (HP:0000090)	2.91540854
14	Excessive salivation (HP:0003781)	2.83957423
15	Congenital primary aphakia (HP:0007707)	2.75659815
16	Chronic hepatic failure (HP:0100626)	2.74960514
17	Chronic otitis media (HP:0000389)	2.70319696
18	Poor coordination (HP:0002370)	2.67306466
19	Lissencephaly (HP:0001339)	2.67024664
20	Nephrogenic diabetes insipidus (HP:0009806)	2.66574035
21	Abnormality of the renal cortex (HP:0011035)	2.62822620
22	Gait imbalance (HP:0002141)	2.60453668
23	Fair hair (HP:0002286)	2.60119193
24	Infantile muscular hypotonia (HP:0008947)	2.59910255
25	Broad alveolar ridges (HP:0000187)	2.54542168
26	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.52465838
27	Chronic sinusitis (HP:0011109)	2.50142038
28	Abnormality of the renal medulla (HP:0100957)	2.43325221
29	Poikiloderma (HP:0001029)	2.42189709
30	Hypothermia (HP:0002045)	2.38290925
31	True hermaphroditism (HP:0010459)	2.38260793
32	Squamous cell carcinoma (HP:0002860)	2.37256814
33	Gonadotropin excess (HP:0000837)	2.36499848
34	Clumsiness (HP:0002312)	2.34891613
35	Abnormal respiratory motile cilium morphology (HP:0005938)	2.33238206
36	Abnormal respiratory epithelium morphology (HP:0012253)	2.33238206
37	Abnormality of DNA repair (HP:0003254)	2.32596756
38	Termporal pattern (HP:0011008)	2.31888643
39	Insidious onset (HP:0003587)	2.31888643
40	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.29330273
41	Neoplasm of the adrenal cortex (HP:0100641)	2.29319724
42	Pancreatic fibrosis (HP:0100732)	2.28371533
43	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.24819335
44	Abnormality of alanine metabolism (HP:0010916)	2.24819335
45	Hyperalaninemia (HP:0003348)	2.24819335
46	Tented upper lip vermilion (HP:0010804)	2.24703447
47	Chromsome breakage (HP:0040012)	2.24701061
48	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.23406328
49	Absent speech (HP:0001344)	2.17074540
50	Upper limb muscle weakness (HP:0003484)	2.16275708
51	Progressive inability to walk (HP:0002505)	2.12403508
52	Pancreatic cysts (HP:0001737)	2.12311767
53	Adrenal hypoplasia (HP:0000835)	2.10311855
54	Small epiphyses (HP:0010585)	2.09781790
55	Hypobetalipoproteinemia (HP:0003563)	2.08405887
56	Decreased testicular size (HP:0008734)	2.07922935
57	Abnormality of the astrocytes (HP:0100707)	2.06240457
58	Astrocytoma (HP:0009592)	2.06240457
59	Deep venous thrombosis (HP:0002625)	2.05058999
60	Enlarged kidneys (HP:0000105)	2.01113015
61	Patellar aplasia (HP:0006443)	1.98488936
62	Volvulus (HP:0002580)	1.98127374
63	Ectopic kidney (HP:0000086)	1.95495967
64	Status epilepticus (HP:0002133)	1.92049241
65	Tapered finger (HP:0001182)	1.91094587
66	Neonatal onset (HP:0003623)	1.90834482
67	Pachygyria (HP:0001302)	1.90487152
68	Atonic seizures (HP:0010819)	1.90240902
69	Osteomalacia (HP:0002749)	1.85606315
70	Entropion (HP:0000621)	1.85446340
71	Abnormality of the wing of the ilium (HP:0011867)	1.83725586
72	Prolonged partial thromboplastin time (HP:0003645)	1.83553505
73	Abnormal pupillary function (HP:0007686)	1.82721592
74	Postaxial foot polydactyly (HP:0001830)	1.81706938
75	Irregular epiphyses (HP:0010582)	1.81499334
76	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.80373594
77	Hypoplasia of the fovea (HP:0007750)	1.80373594
78	Generalized hypopigmentation of hair (HP:0011358)	1.79636470
79	Thyroiditis (HP:0100646)	1.78861734
80	Ependymoma (HP:0002888)	1.77591931
81	Short foot (HP:0001773)	1.76876514
82	Vaginal atresia (HP:0000148)	1.76650164
83	Brushfield spots (HP:0001088)	1.76628756
84	Aplasia/Hypoplasia of the patella (HP:0006498)	1.76601732
85	Attenuation of retinal blood vessels (HP:0007843)	1.76573740
86	Genital tract atresia (HP:0001827)	1.74759309
87	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.74754871
88	Absent epiphyses (HP:0010577)	1.74754871
89	Oligodactyly (hands) (HP:0001180)	1.72445548
90	High anterior hairline (HP:0009890)	1.69651310
91	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.69216376
92	Gastroesophageal reflux (HP:0002020)	1.66738604
93	Aplastic anemia (HP:0001915)	1.66546245
94	Heterotopia (HP:0002282)	1.66093028
95	Hepatoblastoma (HP:0002884)	1.65289813
96	Febrile seizures (HP:0002373)	1.65204703
97	Hypophosphatemic rickets (HP:0004912)	1.64164419
98	Metaphyseal irregularity (HP:0003025)	1.64151765
99	Facial hemangioma (HP:0000329)	1.63856558
100	Increased serum pyruvate (HP:0003542)	1.62422951

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CASK	5.88760102
2	FRK	4.81790528
3	WNK4	3.85341358
4	INSRR	3.03574717
5	STK39	2.99314882
6	ICK	2.63399089
7	PINK1	2.56984029
8	CAMK1D	2.40042966
9	MAP2K7	2.31408207
10	MAP3K4	2.25769938
11	AKT3	1.91672255
12	MUSK	1.76013476
13	SIK2	1.75201052
14	CAMK1G	1.68477002
15	CDK12	1.66975333
16	PLK4	1.63024264
17	DYRK3	1.55465662
18	FGFR3	1.50318746
19	BRSK2	1.47710782
20	BRD4	1.44208616
21	FGFR2	1.39886640
22	MET	1.30310612
23	ZAK	1.23103413
24	CAMKK2	1.20438084
25	WNK3	1.18904609
26	NEK2	1.13681962
27	CDK8	1.08329045
28	CDC7	1.05053143
29	LATS1	1.04521353
30	TLK1	1.04038716
31	ATR	1.02150774
32	BMPR1B	0.99094282
33	EIF2AK3	0.97939634
34	CAMK4	0.95718409
35	MST1R	0.92503793
36	PHKG2	0.90690106
37	PHKG1	0.90690106
38	PRKAA2	0.87602793
39	FGFR4	0.84774077
40	PLK1	0.82943578
41	ADRBK2	0.82687218
42	CSNK1A1L	0.80246683
43	BCR	0.79263984
44	OXSR1	0.79079347
45	ATM	0.78561307
46	EPHB1	0.77712929
47	PRKAA1	0.77041103
48	PIK3CA	0.73664883
49	EEF2K	0.72135970
50	WNK1	0.69097562
51	TYRO3	0.67723779
52	NEK1	0.67426281
53	SGK3	0.67147265
54	MARK1	0.66373695
55	RIPK1	0.65431051
56	SGK2	0.64634124
57	PLK2	0.64265671
58	CHEK1	0.64207887
59	CHUK	0.61432345
60	WEE1	0.61291080
61	ERBB3	0.60409028
62	MST4	0.60082087
63	CCNB1	0.59987469
64	PRKCE	0.58662534
65	CSNK1G1	0.57798101
66	TGFBR2	0.57758477
67	TRIM28	0.57106550
68	MAP2K4	0.56785534
69	PAK3	0.56675927
70	PDK2	0.56539126
71	MAP3K5	0.56166629
72	NTRK2	0.54849245
73	NEK9	0.54185250
74	RPS6KA4	0.54092548
75	CHEK2	0.53671394
76	CSNK1G3	0.51397913
77	NTRK3	0.50652168
78	MAP3K6	0.50096711
79	MAP3K14	0.49674798
80	VRK1	0.47722772
81	SGK494	0.47651202
82	SGK223	0.47651202
83	MAPK13	0.47493480
84	CDK7	0.47306515
85	MAP3K7	0.47190260
86	MAPK11	0.46105997
87	PLK3	0.46030970
88	OBSCN	0.45345559
89	STK38L	0.44430106
90	SRPK1	0.43978447
91	CDK1	0.43112119
92	MELK	0.42750950
93	EPHB2	0.41307905
94	PRKD2	0.41004545
95	BRSK1	0.40610018
96	IRAK3	0.40170463
97	MARK2	0.40021713
98	CDK2	0.39307178
99	MAP3K13	0.38172169
100	LIMK1	0.37054092

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Basal transcription factors_Homo sapiens_hsa03022	3.24307384
2	Non-homologous end-joining_Homo sapiens_hsa03450	3.08159313
3	RNA polymerase_Homo sapiens_hsa03020	3.01165163
4	Steroid biosynthesis_Homo sapiens_hsa00100	2.90736652
5	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.74625987
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.70117440
7	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.68082459
8	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.62258686
9	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	2.54766912
10	Fanconi anemia pathway_Homo sapiens_hsa03460	2.30940201
11	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.21639715
12	ABC transporters_Homo sapiens_hsa02010	2.18268050
13	Butanoate metabolism_Homo sapiens_hsa00650	2.14588613
14	Nucleotide excision repair_Homo sapiens_hsa03420	2.01164686
15	Fatty acid metabolism_Homo sapiens_hsa01212	1.91006169
16	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.87703347
17	Homologous recombination_Homo sapiens_hsa03440	1.87128877
18	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.86061787
19	RNA degradation_Homo sapiens_hsa03018	1.82306228
20	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.77046444
21	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.71933002
22	RNA transport_Homo sapiens_hsa03013	1.67683365
23	Peroxisome_Homo sapiens_hsa04146	1.61673388
24	Selenocompound metabolism_Homo sapiens_hsa00450	1.59973590
25	Lysine degradation_Homo sapiens_hsa00310	1.59716657
26	Protein export_Homo sapiens_hsa03060	1.58717938
27	One carbon pool by folate_Homo sapiens_hsa00670	1.42244064
28	Propanoate metabolism_Homo sapiens_hsa00640	1.42095022
29	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.39568493
30	Pyrimidine metabolism_Homo sapiens_hsa00240	1.37446645
31	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.36156172
32	Base excision repair_Homo sapiens_hsa03410	1.35699210
33	Circadian rhythm_Homo sapiens_hsa04710	1.32674837
34	Fatty acid elongation_Homo sapiens_hsa00062	1.24268423
35	Cell cycle_Homo sapiens_hsa04110	1.21288415
36	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.21258954
37	Mismatch repair_Homo sapiens_hsa03430	1.20266082
38	Phototransduction_Homo sapiens_hsa04744	1.18666201
39	Regulation of autophagy_Homo sapiens_hsa04140	1.16557681
40	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.07015742
41	Complement and coagulation cascades_Homo sapiens_hsa04610	0.97277617
42	Purine metabolism_Homo sapiens_hsa00230	0.96641566
43	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.96272797
44	Taste transduction_Homo sapiens_hsa04742	0.87496370
45	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.85583611
46	p53 signaling pathway_Homo sapiens_hsa04115	0.85139226
47	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.83870680
48	FoxO signaling pathway_Homo sapiens_hsa04068	0.81192840
49	Pyruvate metabolism_Homo sapiens_hsa00620	0.76541762
50	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.75658655
51	Fatty acid degradation_Homo sapiens_hsa00071	0.75519914
52	Tryptophan metabolism_Homo sapiens_hsa00380	0.75481647
53	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.74595151
54	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.73124062
55	mTOR signaling pathway_Homo sapiens_hsa04150	0.72901806
56	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.71464454
57	Insulin resistance_Homo sapiens_hsa04931	0.70337546
58	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.70197179
59	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.67374541
60	mRNA surveillance pathway_Homo sapiens_hsa03015	0.62590579
61	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.60842951
62	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.60649111
63	DNA replication_Homo sapiens_hsa03030	0.57895801
64	Spliceosome_Homo sapiens_hsa03040	0.56384564
65	Glucagon signaling pathway_Homo sapiens_hsa04922	0.56124538
66	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.55331181
67	Metabolic pathways_Homo sapiens_hsa01100	0.54341074
68	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.53208865
69	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.52483602
70	Basal cell carcinoma_Homo sapiens_hsa05217	0.51264236
71	Proteasome_Homo sapiens_hsa03050	0.50487456
72	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.49578710
73	Insulin secretion_Homo sapiens_hsa04911	0.48912264
74	PPAR signaling pathway_Homo sapiens_hsa03320	0.47564732
75	Hippo signaling pathway_Homo sapiens_hsa04390	0.46121018
76	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.46063562
77	Sulfur metabolism_Homo sapiens_hsa00920	0.44206949
78	Axon guidance_Homo sapiens_hsa04360	0.44051647
79	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.43788228
80	Fat digestion and absorption_Homo sapiens_hsa04975	0.42926953
81	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.42170490
82	Small cell lung cancer_Homo sapiens_hsa05222	0.40440133
83	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.38874215
84	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.37455078
85	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.37146504
86	MicroRNAs in cancer_Homo sapiens_hsa05206	0.35825108
87	Ether lipid metabolism_Homo sapiens_hsa00565	0.35542231
88	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.33810944
89	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.33086035
90	AMPK signaling pathway_Homo sapiens_hsa04152	0.32732973
91	Nicotine addiction_Homo sapiens_hsa05033	0.30715136
92	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.30457676
93	Viral carcinogenesis_Homo sapiens_hsa05203	0.30223660
94	Collecting duct acid secretion_Homo sapiens_hsa04966	0.29408638
95	Primary immunodeficiency_Homo sapiens_hsa05340	0.26176505
96	Olfactory transduction_Homo sapiens_hsa04740	0.23550667
97	Hepatitis B_Homo sapiens_hsa05161	0.22313664
98	Calcium signaling pathway_Homo sapiens_hsa04020	0.21904170
99	Dopaminergic synapse_Homo sapiens_hsa04728	0.20696048
100	Glycerolipid metabolism_Homo sapiens_hsa00561	0.20522173

ZNF343

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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