ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.06070151
2	L-fucose catabolic process (GO:0042355)	4.54523247
3	fucose catabolic process (GO:0019317)	4.54523247
4	L-fucose metabolic process (GO:0042354)	4.54523247
5	regulation of heat generation (GO:0031650)	4.38183802
6	cerebral cortex radially oriented cell migration (GO:0021799)	3.84196267
7	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.59411577
8	respiratory chain complex IV assembly (GO:0008535)	3.57150615
9	response to pheromone (GO:0019236)	3.54034075
10	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.52392478
11	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.48687942
12	response to nerve growth factor (GO:1990089)	3.43443010
13	cellular response to nerve growth factor stimulus (GO:1990090)	3.43443010
14	protein localization to endosome (GO:0036010)	3.39011173
15	preassembly of GPI anchor in ER membrane (GO:0016254)	3.35409147
16	detection of light stimulus involved in sensory perception (GO:0050962)	3.35102448
17	detection of light stimulus involved in visual perception (GO:0050908)	3.35102448
18	regulation of cilium movement (GO:0003352)	3.31990534
19	regulation of protein glycosylation (GO:0060049)	3.31080177
20	DNA methylation involved in gamete generation (GO:0043046)	3.29002639
21	piRNA metabolic process (GO:0034587)	3.27539162
22	adaptation of signaling pathway (GO:0023058)	3.27393629
23	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	3.25504654
24	replication fork processing (GO:0031297)	3.22963451
25	axoneme assembly (GO:0035082)	3.22623938
26	protein localization to cilium (GO:0061512)	3.22075816
27	sphingosine metabolic process (GO:0006670)	3.17582913
28	indolalkylamine metabolic process (GO:0006586)	3.15118088
29	cornea development in camera-type eye (GO:0061303)	3.12070317
30	sphingoid metabolic process (GO:0046519)	3.11743098
31	protein polyglutamylation (GO:0018095)	3.11249641
32	establishment of nucleus localization (GO:0040023)	3.08468989
33	epithelial cilium movement (GO:0003351)	3.04689487
34	neural tube formation (GO:0001841)	3.04252276
35	synaptic transmission, cholinergic (GO:0007271)	3.02256558
36	platelet dense granule organization (GO:0060155)	3.00635580
37	behavioral response to ethanol (GO:0048149)	2.98936678
38	cytochrome complex assembly (GO:0017004)	2.98556399
39	diol metabolic process (GO:0034311)	2.98310791
40	indole-containing compound catabolic process (GO:0042436)	2.98204771
41	indolalkylamine catabolic process (GO:0046218)	2.98204771
42	tryptophan catabolic process (GO:0006569)	2.98204771
43	head development (GO:0060322)	2.93193763
44	intracellular lipid transport (GO:0032365)	2.92171389
45	mannosylation (GO:0097502)	2.88579331
46	negative regulation of mast cell activation (GO:0033004)	2.88566558
47	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.88383082
48	nonmotile primary cilium assembly (GO:0035058)	2.88148916
49	negative regulation of multicellular organism growth (GO:0040015)	2.87913944
50	photoreceptor cell maintenance (GO:0045494)	2.84564754
51	establishment of protein localization to Golgi (GO:0072600)	2.83240205
52	DNA deamination (GO:0045006)	2.83196745
53	reflex (GO:0060004)	2.81876256
54	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.81380252
55	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.78946781
56	transmission of nerve impulse (GO:0019226)	2.78850000
57	kynurenine metabolic process (GO:0070189)	2.77418457
58	nucleoside diphosphate catabolic process (GO:0009134)	2.76506600
59	centriole replication (GO:0007099)	2.74580844
60	gene silencing by RNA (GO:0031047)	2.74459065
61	positive regulation of cardiac muscle cell differentiation (GO:2000727)	2.73630993
62	cellular ketone body metabolic process (GO:0046950)	2.72904547
63	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.72381699
64	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.71987716
65	atrial cardiac muscle cell action potential (GO:0086014)	2.71877074
66	cellular response to ATP (GO:0071318)	2.68351596
67	oxidative phosphorylation (GO:0006119)	2.66415807
68	microtubule depolymerization (GO:0007019)	2.64991125
69	C4-dicarboxylate transport (GO:0015740)	2.64220670
70	cilium morphogenesis (GO:0060271)	2.64018349
71	negative regulation of telomere maintenance (GO:0032205)	2.63433967
72	tryptophan metabolic process (GO:0006568)	2.62721934
73	primary amino compound metabolic process (GO:1901160)	2.58583677
74	water-soluble vitamin biosynthetic process (GO:0042364)	2.56958113
75	RNA destabilization (GO:0050779)	2.56341419
76	presynaptic membrane assembly (GO:0097105)	2.56295125
77	neuronal action potential (GO:0019228)	2.56245916
78	sympathetic nervous system development (GO:0048485)	2.55856352
79	pyrimidine nucleobase catabolic process (GO:0006208)	2.55735861
80	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.55474025
81	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	2.55398413
82	C-terminal protein amino acid modification (GO:0018410)	2.55248242
83	C-terminal protein lipidation (GO:0006501)	2.53529674
84	DNA-dependent DNA replication (GO:0006261)	2.53061897
85	negative regulation of nucleotide biosynthetic process (GO:0030809)	2.51679860
86	negative regulation of purine nucleotide biosynthetic process (GO:1900372)	2.51679860
87	nucleobase catabolic process (GO:0046113)	2.50724856
88	regulation of action potential (GO:0098900)	2.50063596
89	cilium movement (GO:0003341)	2.49375408
90	limb bud formation (GO:0060174)	2.49249756
91	regulation of energy homeostasis (GO:2000505)	2.49180645
92	GPI anchor metabolic process (GO:0006505)	2.45826582
93	protein complex biogenesis (GO:0070271)	2.45763174
94	mitochondrial respiratory chain complex assembly (GO:0033108)	2.45337980
95	hindbrain development (GO:0030902)	2.45207882
96	cilium organization (GO:0044782)	2.45029830
97	protein import into peroxisome matrix (GO:0016558)	2.44537499
98	lateral ventricle development (GO:0021670)	2.43360570
99	mechanosensory behavior (GO:0007638)	2.43345429
100	NADH dehydrogenase complex assembly (GO:0010257)	2.43162421

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.60280651
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.23565507
3	EZH2_22144423_ChIP-Seq_EOC_Human	2.89372278
4	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.79055325
5	VDR_22108803_ChIP-Seq_LS180_Human	2.77306696
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.70924635
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.61554938
8	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.59864591
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.54669841
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.49705078
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.40553535
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.39324611
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.28150098
14	EWS_26573619_Chip-Seq_HEK293_Human	2.26454203
15	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.22853012
16	P300_19829295_ChIP-Seq_ESCs_Human	2.17196606
17	FUS_26573619_Chip-Seq_HEK293_Human	2.12623356
18	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.05281353
19	ER_23166858_ChIP-Seq_MCF-7_Human	2.01734315
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.93994212
21	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.90733199
22	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.76027030
23	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.74371985
24	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.70297219
25	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.68278573
26	STAT3_23295773_ChIP-Seq_U87_Human	1.65589351
27	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.64926980
28	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.64146113
29	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.63431055
30	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.62448596
31	CBP_20019798_ChIP-Seq_JUKART_Human	1.62448596
32	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.62289412
33	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.61042922
34	BCAT_22108803_ChIP-Seq_LS180_Human	1.57978060
35	TCF4_23295773_ChIP-Seq_U87_Human	1.56383340
36	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.56267572
37	SOX2_19829295_ChIP-Seq_ESCs_Human	1.54278026
38	NANOG_19829295_ChIP-Seq_ESCs_Human	1.54278026
39	SMAD4_21799915_ChIP-Seq_A2780_Human	1.53293174
40	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.52145126
41	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.51582244
42	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.51349411
43	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.50771583
44	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.50771583
45	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.49697428
46	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.45808834
47	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.44098415
48	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.43436204
49	TP53_22573176_ChIP-Seq_HFKS_Human	1.40185838
50	AR_25329375_ChIP-Seq_VCAP_Human	1.39924572
51	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.39814127
52	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.39806536
53	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.37509668
54	REST_21632747_ChIP-Seq_MESCs_Mouse	1.37197132
55	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.37181880
56	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.37076430
57	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.36746759
58	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.34418509
59	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.33539872
60	TCF4_22108803_ChIP-Seq_LS180_Human	1.32736049
61	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.29458841
62	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.28596229
63	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.28338231
64	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.26787825
65	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.25693502
66	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.25064613
67	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.24080511
68	P53_22387025_ChIP-Seq_ESCs_Mouse	1.23836631
69	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.22889395
70	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.22578033
71	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.21733291
72	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.21465613
73	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.19062494
74	IRF1_19129219_ChIP-ChIP_H3396_Human	1.15759770
75	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.15738109
76	RUNX2_22187159_ChIP-Seq_PCA_Human	1.14030547
77	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.12167716
78	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.11709164
79	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.11470960
80	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.11454437
81	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.10782961
82	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.10568997
83	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.10226983
84	AR_21572438_ChIP-Seq_LNCaP_Human	1.10060858
85	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.09219544
86	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.08366800
87	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.08187512
88	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.08065736
89	MYC_19829295_ChIP-Seq_ESCs_Human	1.07112979
90	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.05783751
91	TP53_16413492_ChIP-PET_HCT116_Human	1.05086417
92	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.04984399
93	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.03959824
94	RNF2_27304074_Chip-Seq_NSC_Mouse	1.03245499
95	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.02687451
96	NCOR_22424771_ChIP-Seq_293T_Human	1.02155383
97	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.02038094
98	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01532050
99	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.01295156
100	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.01295156

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004043_abnormal_pH_regulation	3.42108054
2	MP0002837_dystrophic_cardiac_calcinosis	3.38791485
3	MP0002653_abnormal_ependyma_morphology	3.03957604
4	MP0003195_calcinosis	2.94414359
5	MP0001984_abnormal_olfaction	2.54467693
6	MP0001968_abnormal_touch/_nociception	2.22573676
7	MP0005645_abnormal_hypothalamus_physiol	2.22438223
8	MP0008877_abnormal_DNA_methylation	2.19166887
9	MP0000569_abnormal_digit_pigmentation	2.18175114
10	MP0000427_abnormal_hair_cycle	2.12035668
11	MP0001986_abnormal_taste_sensitivity	2.08942596
12	MP0002102_abnormal_ear_morphology	2.07549411
13	MP0003646_muscle_fatigue	2.06073630
14	MP0005646_abnormal_pituitary_gland	2.03740120
15	MP0002876_abnormal_thyroid_physiology	1.98939063
16	MP0005551_abnormal_eye_electrophysiolog	1.93516507
17	MP0009745_abnormal_behavioral_response	1.92554581
18	MP0008875_abnormal_xenobiotic_pharmacok	1.90781071
19	MP0006292_abnormal_olfactory_placode	1.87699906
20	MP0009046_muscle_twitch	1.80181756
21	MP0008872_abnormal_physiological_respon	1.79507580
22	MP0002272_abnormal_nervous_system	1.78031044
23	MP0001501_abnormal_sleep_pattern	1.75755574
24	MP0003136_yellow_coat_color	1.74317478
25	MP0000631_abnormal_neuroendocrine_gland	1.73268960
26	MP0002638_abnormal_pupillary_reflex	1.69032685
27	MP0003880_abnormal_central_pattern	1.67766356
28	MP0002234_abnormal_pharynx_morphology	1.65065773
29	MP0001486_abnormal_startle_reflex	1.62289960
30	MP0002736_abnormal_nociception_after	1.61719811
31	MP0003787_abnormal_imprinting	1.58829420
32	MP0005253_abnormal_eye_physiology	1.56304033
33	MP0006276_abnormal_autonomic_nervous	1.54901876
34	MP0004885_abnormal_endolymph	1.52859724
35	MP0001485_abnormal_pinna_reflex	1.51532215
36	MP0001529_abnormal_vocalization	1.43149568
37	MP0002064_seizures	1.42069961
38	MP0002572_abnormal_emotion/affect_behav	1.39993831
39	MP0006072_abnormal_retinal_apoptosis	1.34894848
40	MP0004133_heterotaxia	1.33294201
41	MP0002928_abnormal_bile_duct	1.33119873
42	MP0005171_absent_coat_pigmentation	1.32231093
43	MP0002735_abnormal_chemical_nociception	1.28386944
44	MP0000778_abnormal_nervous_system	1.26863251
45	MP0002751_abnormal_autonomic_nervous	1.26035912
46	MP0005386_behavior/neurological_phenoty	1.23754698
47	MP0004924_abnormal_behavior	1.23754698
48	MP0002733_abnormal_thermal_nociception	1.19743992
49	MP0004484_altered_response_of	1.18797852
50	MP0001970_abnormal_pain_threshold	1.17207618
51	MP0002822_catalepsy	1.16012152
52	MP0002063_abnormal_learning/memory/cond	1.14083519
53	MP0002095_abnormal_skin_pigmentation	1.14061203
54	MP0008789_abnormal_olfactory_epithelium	1.13977326
55	MP0002160_abnormal_reproductive_system	1.13376247
56	MP0004142_abnormal_muscle_tone	1.13073342
57	MP0005410_abnormal_fertilization	1.11985085
58	MP0002557_abnormal_social/conspecific_i	1.08250239
59	MP0000647_abnormal_sebaceous_gland	1.08198736
60	MP0002734_abnormal_mechanical_nocicepti	1.08020853
61	MP0010386_abnormal_urinary_bladder	1.07769028
62	MP0003567_abnormal_fetal_cardiomyocyte	1.06678250
63	MP0003635_abnormal_synaptic_transmissio	1.06288740
64	MP0004147_increased_porphyrin_level	1.04562481
65	MP0003011_delayed_dark_adaptation	1.04401119
66	MP0002233_abnormal_nose_morphology	1.01613156
67	MP0003121_genomic_imprinting	1.00058345
68	MP0002938_white_spotting	0.98658359
69	MP0002067_abnormal_sensory_capabilities	0.98133658
70	MP0002184_abnormal_innervation	0.96370540
71	MP0003890_abnormal_embryonic-extraembry	0.95348628
72	MP0005389_reproductive_system_phenotype	0.93509447
73	MP0003045_fibrosis	0.92874351
74	MP0005187_abnormal_penis_morphology	0.91405052
75	MP0005084_abnormal_gallbladder_morpholo	0.90094770
76	MP0003137_abnormal_impulse_conducting	0.89606571
77	MP0000049_abnormal_middle_ear	0.88960169
78	MP0008775_abnormal_heart_ventricle	0.88478050
79	MP0003698_abnormal_male_reproductive	0.88304579
80	MP0004742_abnormal_vestibular_system	0.88251771
81	MP0005174_abnormal_tail_pigmentation	0.88158929
82	MP0000230_abnormal_systemic_arterial	0.87439060
83	MP0000372_irregular_coat_pigmentation	0.86986896
84	MP0002138_abnormal_hepatobiliary_system	0.83389091
85	MP0000613_abnormal_salivary_gland	0.82190274
86	MP0001929_abnormal_gametogenesis	0.81295936
87	MP0002168_other_aberrant_phenotype	0.77531567
88	MP0002693_abnormal_pancreas_physiology	0.77522357
89	MP0005220_abnormal_exocrine_pancreas	0.76849621
90	MP0003943_abnormal_hepatobiliary_system	0.76809862
91	MP0005394_taste/olfaction_phenotype	0.75997067
92	MP0005499_abnormal_olfactory_system	0.75997067
93	MP0003718_maternal_effect	0.75698186
94	MP0004085_abnormal_heartbeat	0.74084816
95	MP0001905_abnormal_dopamine_level	0.73988929
96	MP0002909_abnormal_adrenal_gland	0.73691760
97	MP0005379_endocrine/exocrine_gland_phen	0.72880029
98	MP0001324_abnormal_eye_pigmentation	0.72670341
99	MP0002882_abnormal_neuron_morphology	0.72514796
100	MP0002752_abnormal_somatic_nervous	0.71557069

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.40025603
2	Broad-based gait (HP:0002136)	4.38151980
3	Type II lissencephaly (HP:0007260)	4.05105831
4	Hyperventilation (HP:0002883)	3.77429856
5	Inability to walk (HP:0002540)	3.63424021
6	Pancreatic fibrosis (HP:0100732)	3.56934034
7	Progressive inability to walk (HP:0002505)	3.51458701
8	True hermaphroditism (HP:0010459)	3.40179121
9	Molar tooth sign on MRI (HP:0002419)	3.32821727
10	Abnormality of midbrain morphology (HP:0002418)	3.32821727
11	Nephronophthisis (HP:0000090)	3.31137695
12	Abnormality of the renal cortex (HP:0011035)	3.25279201
13	Focal motor seizures (HP:0011153)	3.19240385
14	Congenital stationary night blindness (HP:0007642)	3.10022124
15	Abnormality of the renal medulla (HP:0100957)	3.08397779
16	Medial flaring of the eyebrow (HP:0010747)	3.08221433
17	Attenuation of retinal blood vessels (HP:0007843)	2.99392359
18	Renal cortical cysts (HP:0000803)	2.99121777
19	Lissencephaly (HP:0001339)	2.88636022
20	Long nose (HP:0003189)	2.87344867
21	Conical tooth (HP:0000698)	2.83074017
22	Fair hair (HP:0002286)	2.77546423
23	Cystic liver disease (HP:0006706)	2.74028642
24	Pachygyria (HP:0001302)	2.68444527
25	Abnormality of the labia minora (HP:0012880)	2.61238655
26	Abolished electroretinogram (ERG) (HP:0000550)	2.55778070
27	Calf muscle hypertrophy (HP:0008981)	2.54186634
28	Retinal dysplasia (HP:0007973)	2.52734931
29	Gait imbalance (HP:0002141)	2.48554406
30	Protruding tongue (HP:0010808)	2.48478471
31	Bulbous nose (HP:0000414)	2.47749961
32	Widely spaced teeth (HP:0000687)	2.44841883
33	Pendular nystagmus (HP:0012043)	2.43980947
34	Chronic hepatic failure (HP:0100626)	2.43830782
35	Congenital primary aphakia (HP:0007707)	2.40743081
36	Clumsiness (HP:0002312)	2.39722606
37	Stomach cancer (HP:0012126)	2.38314476
38	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.38138138
39	Absent/shortened dynein arms (HP:0200106)	2.38138138
40	Reduced antithrombin III activity (HP:0001976)	2.36536297
41	Absent speech (HP:0001344)	2.35075477
42	Gaze-evoked nystagmus (HP:0000640)	2.33978419
43	Neoplasm of the oral cavity (HP:0100649)	2.33928110
44	Colon cancer (HP:0003003)	2.30922704
45	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.20945010
46	Nephrogenic diabetes insipidus (HP:0009806)	2.20116528
47	Genital tract atresia (HP:0001827)	2.19352513
48	Muscle hypertrophy of the lower extremities (HP:0008968)	2.17914194
49	Febrile seizures (HP:0002373)	2.16364809
50	Abnormality of macular pigmentation (HP:0008002)	2.15339211
51	Clubbing of toes (HP:0100760)	2.14393655
52	Amelogenesis imperfecta (HP:0000705)	2.12823689
53	Exotropia (HP:0000577)	2.12643358
54	Type I transferrin isoform profile (HP:0003642)	2.12583576
55	Congenital hepatic fibrosis (HP:0002612)	2.12100272
56	Vaginal atresia (HP:0000148)	2.11934983
57	Thyroiditis (HP:0100646)	2.07108951
58	Neoplasm of the adrenal cortex (HP:0100641)	2.04322109
59	Focal seizures (HP:0007359)	2.00086146
60	Sclerocornea (HP:0000647)	1.99105933
61	Generalized hypopigmentation of hair (HP:0011358)	1.98542935
62	Abnormal drinking behavior (HP:0030082)	1.97642509
63	Polydipsia (HP:0001959)	1.97642509
64	Large for gestational age (HP:0001520)	1.97517333
65	Abnormal rod and cone electroretinograms (HP:0008323)	1.96900166
66	Furrowed tongue (HP:0000221)	1.96156870
67	Dialeptic seizures (HP:0011146)	1.93607904
68	Abnormal biliary tract physiology (HP:0012439)	1.93603384
69	Bile duct proliferation (HP:0001408)	1.93603384
70	Poor coordination (HP:0002370)	1.92649335
71	Ketoacidosis (HP:0001993)	1.92609647
72	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.92399204
73	Keratoconus (HP:0000563)	1.88826575
74	Increased corneal curvature (HP:0100692)	1.88826575
75	Postaxial foot polydactyly (HP:0001830)	1.87938322
76	Drooling (HP:0002307)	1.86333710
77	Constricted visual fields (HP:0001133)	1.85662750
78	Hypothermia (HP:0002045)	1.85341780
79	Abnormality of the parathyroid morphology (HP:0011766)	1.84501218
80	Anencephaly (HP:0002323)	1.82316882
81	Enlarged kidneys (HP:0000105)	1.77911406
82	Male pseudohermaphroditism (HP:0000037)	1.75390805
83	Tubular atrophy (HP:0000092)	1.74603728
84	Polyuria (HP:0000103)	1.73998258
85	Excessive salivation (HP:0003781)	1.73520503
86	Abnormal respiratory motile cilium morphology (HP:0005938)	1.73050959
87	Abnormal respiratory epithelium morphology (HP:0012253)	1.73050959
88	Postaxial hand polydactyly (HP:0001162)	1.72502681
89	Small hand (HP:0200055)	1.71896048
90	Polymicrogyria (HP:0002126)	1.71890720
91	Abnormal ciliary motility (HP:0012262)	1.71479442
92	Abnormal protein glycosylation (HP:0012346)	1.71427955
93	Abnormal glycosylation (HP:0012345)	1.71427955
94	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.71427955
95	Abnormal protein N-linked glycosylation (HP:0012347)	1.71427955
96	Severe muscular hypotonia (HP:0006829)	1.71160515
97	Tubulointerstitial nephritis (HP:0001970)	1.71072008
98	Decreased central vision (HP:0007663)	1.69641726
99	Metaphyseal dysplasia (HP:0100255)	1.68942875
100	Prominent nasal bridge (HP:0000426)	1.67943443

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.02120269
2	TAOK3	3.27868977
3	ADRBK2	3.01998567
4	PINK1	2.73327912
5	LATS1	2.67935308
6	ZAK	2.40351580
7	NUAK1	2.32263172
8	BMPR1B	2.27407810
9	BCR	2.25366589
10	MAP4K2	2.11932510
11	WNK3	2.09511583
12	GRK1	2.03607597
13	WNK4	2.02070248
14	TNIK	1.99785855
15	CDK19	1.95304014
16	INSRR	1.74665735
17	STK38L	1.69496887
18	CDK3	1.62764721
19	MAPK13	1.59683904
20	CASK	1.57021268
21	CDC42BPA	1.43900557
22	ACVR1B	1.42560429
23	MARK1	1.41222142
24	OXSR1	1.36308684
25	TEC	1.29776269
26	TXK	1.25670399
27	DAPK2	1.23495339
28	ADRBK1	1.22270731
29	FGFR2	1.21466308
30	TGFBR2	1.20836649
31	STK3	1.19625313
32	MAP3K4	1.15508226
33	STK39	1.13571669
34	NLK	1.11542171
35	WNK1	1.08613928
36	SIK2	1.07327046
37	TLK1	1.03918791
38	TRIM28	0.96193042
39	CAMKK2	0.91633948
40	PRKCE	0.91081974
41	PRKCG	0.86117464
42	CSNK1A1L	0.85819170
43	DYRK2	0.84828945
44	NTRK3	0.84057252
45	DYRK3	0.83718921
46	KIT	0.81685561
47	RPS6KA4	0.80494244
48	PHKG2	0.75935825
49	PHKG1	0.75935825
50	STK38	0.75876445
51	CAMK2A	0.75549115
52	MAP2K7	0.74785043
53	EIF2AK3	0.74592557
54	TIE1	0.69989852
55	STK11	0.69856869
56	CSNK1G2	0.67046419
57	CSNK1G1	0.66348038
58	ABL1	0.64242233
59	MAP2K6	0.63857386
60	EPHA4	0.61925352
61	HCK	0.60574059
62	SGK2	0.60398158
63	IKBKB	0.60277418
64	RPS6KA5	0.59814235
65	CSNK1G3	0.59683036
66	MKNK2	0.58506769
67	PIK3CA	0.58121690
68	VRK1	0.58039011
69	IKBKE	0.57746525
70	ITK	0.56117050
71	PTK2B	0.55984838
72	NTRK2	0.54762362
73	PRKD3	0.53663130
74	LCK	0.53456414
75	TGFBR1	0.52028877
76	PAK3	0.51203901
77	MAP2K2	0.49688248
78	PRKAA2	0.48527881
79	ATM	0.47457823
80	PRKACA	0.44948873
81	CHUK	0.41905310
82	BRSK2	0.41532629
83	OBSCN	0.40112672
84	PRKDC	0.39798443
85	PLK2	0.39714641
86	MAPK15	0.39639410
87	CAMK4	0.38784637
88	PRKCQ	0.37727446
89	GRK5	0.37585313
90	CSNK1A1	0.37067123
91	SGK494	0.36838237
92	SGK223	0.36838237
93	FLT3	0.35835140
94	PRKCZ	0.35781740
95	SYK	0.34414470
96	TNK2	0.34035866
97	MAP3K7	0.33172115
98	CCNB1	0.32103915
99	PLK4	0.31843669
100	PLK3	0.30940790

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.21342210
2	Phototransduction_Homo sapiens_hsa04744	3.05474678
3	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.98013072
4	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.95123737
5	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.77980686
6	Nicotine addiction_Homo sapiens_hsa05033	2.59494823
7	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.32277235
8	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.31007289
9	Butanoate metabolism_Homo sapiens_hsa00650	2.27110517
10	Regulation of autophagy_Homo sapiens_hsa04140	2.25015448
11	Nitrogen metabolism_Homo sapiens_hsa00910	2.15670168
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.15581105
13	Taste transduction_Homo sapiens_hsa04742	2.11021977
14	Selenocompound metabolism_Homo sapiens_hsa00450	2.07157688
15	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.97460016
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.96799962
17	Morphine addiction_Homo sapiens_hsa05032	1.69477083
18	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.62859557
19	Olfactory transduction_Homo sapiens_hsa04740	1.59271093
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.59063371
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.55477964
22	Insulin secretion_Homo sapiens_hsa04911	1.54619592
23	Caffeine metabolism_Homo sapiens_hsa00232	1.54206432
24	ABC transporters_Homo sapiens_hsa02010	1.44582004
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.42858922
26	Ether lipid metabolism_Homo sapiens_hsa00565	1.42373649
27	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.40541831
28	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.40345870
29	Propanoate metabolism_Homo sapiens_hsa00640	1.37265601
30	Glutamatergic synapse_Homo sapiens_hsa04724	1.33320396
31	Non-homologous end-joining_Homo sapiens_hsa03450	1.32870366
32	RNA degradation_Homo sapiens_hsa03018	1.26704959
33	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.23295585
34	GABAergic synapse_Homo sapiens_hsa04727	1.21621246
35	Homologous recombination_Homo sapiens_hsa03440	1.21554834
36	Circadian entrainment_Homo sapiens_hsa04713	1.18265653
37	Basal transcription factors_Homo sapiens_hsa03022	1.18254571
38	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.17273505
39	Peroxisome_Homo sapiens_hsa04146	1.16223964
40	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.11649407
41	Protein export_Homo sapiens_hsa03060	1.10170317
42	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.06801017
43	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.06168416
44	Asthma_Homo sapiens_hsa05310	1.05852225
45	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.02114979
46	Oxidative phosphorylation_Homo sapiens_hsa00190	1.01082067
47	Chemical carcinogenesis_Homo sapiens_hsa05204	0.99810748
48	Type I diabetes mellitus_Homo sapiens_hsa04940	0.99551745
49	Salivary secretion_Homo sapiens_hsa04970	0.99145469
50	RNA polymerase_Homo sapiens_hsa03020	0.97095932
51	Serotonergic synapse_Homo sapiens_hsa04726	0.92068767
52	Calcium signaling pathway_Homo sapiens_hsa04020	0.89561438
53	Retinol metabolism_Homo sapiens_hsa00830	0.88233339
54	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.88138942
55	Dopaminergic synapse_Homo sapiens_hsa04728	0.82759777
56	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.82516370
57	Primary immunodeficiency_Homo sapiens_hsa05340	0.80460397
58	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.71272553
59	beta-Alanine metabolism_Homo sapiens_hsa00410	0.70352369
60	Sphingolipid metabolism_Homo sapiens_hsa00600	0.70232339
61	Purine metabolism_Homo sapiens_hsa00230	0.70047118
62	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.68106805
63	Renin secretion_Homo sapiens_hsa04924	0.65608635
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.62959496
65	Glycerolipid metabolism_Homo sapiens_hsa00561	0.62658800
66	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.61525589
67	Graft-versus-host disease_Homo sapiens_hsa05332	0.60603785
68	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.58705793
69	Parkinsons disease_Homo sapiens_hsa05012	0.58400180
70	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.57603662
71	cAMP signaling pathway_Homo sapiens_hsa04024	0.55914584
72	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.55041734
73	Type II diabetes mellitus_Homo sapiens_hsa04930	0.54485432
74	Allograft rejection_Homo sapiens_hsa05330	0.53836217
75	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.52344010
76	Fat digestion and absorption_Homo sapiens_hsa04975	0.47229860
77	Amphetamine addiction_Homo sapiens_hsa05031	0.46416103
78	One carbon pool by folate_Homo sapiens_hsa00670	0.45325531
79	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.45002549
80	Metabolic pathways_Homo sapiens_hsa01100	0.43492761
81	Histidine metabolism_Homo sapiens_hsa00340	0.43150238
82	Pyrimidine metabolism_Homo sapiens_hsa00240	0.41543112
83	Long-term depression_Homo sapiens_hsa04730	0.38533763
84	Fatty acid degradation_Homo sapiens_hsa00071	0.38153872
85	Cholinergic synapse_Homo sapiens_hsa04725	0.37743087
86	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.34936404
87	Cocaine addiction_Homo sapiens_hsa05030	0.33526083
88	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.32314862
89	Huntingtons disease_Homo sapiens_hsa05016	0.32000876
90	Alzheimers disease_Homo sapiens_hsa05010	0.31215738
91	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.30578280
92	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.30137224
93	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.29009599
94	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.27983553
95	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.25220971
96	Collecting duct acid secretion_Homo sapiens_hsa04966	0.23355529
97	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.23106897
98	Axon guidance_Homo sapiens_hsa04360	0.22753500
99	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.21026215
100	Pancreatic secretion_Homo sapiens_hsa04972	0.20733432

ZNF345

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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