ZNF346

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival. It plays a role in protecting neurons by inhibiting cell cycle re-entry via stimulation of p21 gene expression. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)4.82536010
2synapsis (GO:0007129)4.74419040
3iron-sulfur cluster assembly (GO:0016226)4.66907098
4metallo-sulfur cluster assembly (GO:0031163)4.66907098
5positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.43966720
6positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.43966720
7positive regulation of mitotic sister chromatid separation (GO:1901970)4.43966720
8male meiosis I (GO:0007141)4.25666074
9chromosome organization involved in meiosis (GO:0070192)4.22923333
10proteasome assembly (GO:0043248)4.12336086
11prenylation (GO:0097354)4.11292891
12protein prenylation (GO:0018342)4.11292891
13synaptonemal complex assembly (GO:0007130)3.92295171
14DNA methylation involved in gamete generation (GO:0043046)3.89453344
15non-recombinational repair (GO:0000726)3.85676874
16double-strand break repair via nonhomologous end joining (GO:0006303)3.85676874
17regulation of sister chromatid cohesion (GO:0007063)3.84045586
18meiosis I (GO:0007127)3.68616394
19reciprocal DNA recombination (GO:0035825)3.65310324
20reciprocal meiotic recombination (GO:0007131)3.65310324
21DNA integration (GO:0015074)3.55369055
22histone H3-K9 methylation (GO:0051567)3.52714691
23DNA synthesis involved in DNA repair (GO:0000731)3.52412365
24resolution of meiotic recombination intermediates (GO:0000712)3.50733479
25synaptonemal complex organization (GO:0070193)3.42117603
26male meiosis (GO:0007140)3.36883223
27meiotic nuclear division (GO:0007126)3.34856295
28histone H2A acetylation (GO:0043968)3.28437368
29autophagic vacuole fusion (GO:0000046)3.22741670
30fucose catabolic process (GO:0019317)3.22161575
31L-fucose metabolic process (GO:0042354)3.22161575
32L-fucose catabolic process (GO:0042355)3.22161575
33positive regulation of chromosome segregation (GO:0051984)3.20395700
34mitotic recombination (GO:0006312)3.18700529
35meiotic cell cycle process (GO:1903046)3.18244521
36cullin deneddylation (GO:0010388)3.15889075
37telomere maintenance via recombination (GO:0000722)3.15002512
38meiotic chromosome segregation (GO:0045132)3.13934052
39DNA double-strand break processing (GO:0000729)3.12025474
40DNA replication-dependent nucleosome organization (GO:0034723)3.10525499
41DNA replication-dependent nucleosome assembly (GO:0006335)3.10525499
42protein sumoylation (GO:0016925)3.04034100
43replication fork processing (GO:0031297)3.01233560
44microtubule depolymerization (GO:0007019)3.00803812
45pyrimidine nucleobase catabolic process (GO:0006208)3.00678443
46recombinational repair (GO:0000725)2.99278226
47positive regulation of mitochondrial fission (GO:0090141)2.98152566
48double-strand break repair via homologous recombination (GO:0000724)2.94779285
49preassembly of GPI anchor in ER membrane (GO:0016254)2.93654720
50protein deneddylation (GO:0000338)2.93595523
51regulation of meiosis I (GO:0060631)2.92984849
52organelle membrane fusion (GO:0090174)2.92834626
53DNA strand elongation involved in DNA replication (GO:0006271)2.89142791
54somatic hypermutation of immunoglobulin genes (GO:0016446)2.86671095
55somatic diversification of immune receptors via somatic mutation (GO:0002566)2.86671095
56tRNA modification (GO:0006400)2.81023567
57regulation of nuclear cell cycle DNA replication (GO:0033262)2.80001763
58DNA strand elongation (GO:0022616)2.79536326
59negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.79374437
60acrosome assembly (GO:0001675)2.79364761
61seminiferous tubule development (GO:0072520)2.79105320
62peptidyl-histidine modification (GO:0018202)2.78702006
63sister chromatid cohesion (GO:0007062)2.77158047
64response to pheromone (GO:0019236)2.75821623
65protein import into peroxisome matrix (GO:0016558)2.74893529
66protein polyglutamylation (GO:0018095)2.72133907
67mitochondrial RNA metabolic process (GO:0000959)2.71119973
68histone H3-K9 modification (GO:0061647)2.68238503
69chromatin remodeling at centromere (GO:0031055)2.63951196
70behavioral response to nicotine (GO:0035095)2.63600084
71DNA catabolic process, exonucleolytic (GO:0000738)2.61756683
72regulation of mitotic spindle checkpoint (GO:1903504)2.61669809
73regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.61669809
74coenzyme A biosynthetic process (GO:0015937)2.61424314
75DNA recombination (GO:0006310)2.60990892
76telomere maintenance via semi-conservative replication (GO:0032201)2.59362272
77translesion synthesis (GO:0019985)2.57306277
78CENP-A containing nucleosome assembly (GO:0034080)2.55748258
79nucleotide-excision repair, DNA gap filling (GO:0006297)2.55093445
80DNA damage response, detection of DNA damage (GO:0042769)2.53472082
81DNA alkylation (GO:0006305)2.52617440
82DNA methylation (GO:0006306)2.52617440
83maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.51617221
84DNA methylation or demethylation (GO:0044728)2.50443949
85transcription-coupled nucleotide-excision repair (GO:0006283)2.47913821
86regulation of cilium movement (GO:0003352)2.47885233
87protein localization to peroxisome (GO:0072662)2.47847897
88protein targeting to peroxisome (GO:0006625)2.47847897
89establishment of protein localization to peroxisome (GO:0072663)2.47847897
90RNA methylation (GO:0001510)2.47592896
91postreplication repair (GO:0006301)2.47281860
92gene silencing by RNA (GO:0031047)2.47185521
93protein K6-linked ubiquitination (GO:0085020)2.47157913
94histone exchange (GO:0043486)2.46111561
95regulation of sister chromatid segregation (GO:0033045)2.45318994
96regulation of mitotic sister chromatid separation (GO:0010965)2.45318994
97regulation of mitotic sister chromatid segregation (GO:0033047)2.45318994
98telomere maintenance via telomere lengthening (GO:0010833)2.44722312
99DNA replication checkpoint (GO:0000076)2.44664532
100pseudouridine synthesis (GO:0001522)2.44060420

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.32939202
2E2F7_22180533_ChIP-Seq_HELA_Human4.04318482
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.84093330
4ZNF274_21170338_ChIP-Seq_K562_Hela3.17567861
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.94704481
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.82172865
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.78660044
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.71312686
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.70268403
10VDR_22108803_ChIP-Seq_LS180_Human2.67942450
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.64397455
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.59901446
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.59047467
14IGF1R_20145208_ChIP-Seq_DFB_Human2.58061057
15VDR_23849224_ChIP-Seq_CD4+_Human2.26341652
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.23511023
17THAP11_20581084_ChIP-Seq_MESCs_Mouse2.19212874
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.17321557
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.16778876
20PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12601805
21EZH2_22144423_ChIP-Seq_EOC_Human2.09405347
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.08482584
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.05896709
24GABP_19822575_ChIP-Seq_HepG2_Human2.05435949
25YY1_21170310_ChIP-Seq_MESCs_Mouse1.95226172
26IRF1_19129219_ChIP-ChIP_H3396_Human1.93519384
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.90708918
28FOXP3_21729870_ChIP-Seq_TREG_Human1.87373543
29MYC_18940864_ChIP-ChIP_HL60_Human1.82950383
30GATA1_22025678_ChIP-Seq_K562_Human1.82393197
31GBX2_23144817_ChIP-Seq_PC3_Human1.80696813
32DCP1A_22483619_ChIP-Seq_HELA_Human1.79163662
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.77656460
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75765239
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74680312
36MYC_18555785_ChIP-Seq_MESCs_Mouse1.72574411
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.71872501
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.71399410
39FUS_26573619_Chip-Seq_HEK293_Human1.69993327
40FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.69953573
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.66073507
42EWS_26573619_Chip-Seq_HEK293_Human1.62742519
43FOXM1_23109430_ChIP-Seq_U2OS_Human1.61059910
44ELK1_19687146_ChIP-ChIP_HELA_Human1.56539448
45CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.56392572
46TAF15_26573619_Chip-Seq_HEK293_Human1.51405117
47MYC_18358816_ChIP-ChIP_MESCs_Mouse1.50540275
48KDM5A_27292631_Chip-Seq_BREAST_Human1.46437289
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.45268197
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41661541
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40549009
52TTF2_22483619_ChIP-Seq_HELA_Human1.40021916
53KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.37738899
54RNF2_27304074_Chip-Seq_NSC_Mouse1.37287117
55MYC_19030024_ChIP-ChIP_MESCs_Mouse1.36376206
56CIITA_25753668_ChIP-Seq_RAJI_Human1.36238287
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36062442
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34475243
59XRN2_22483619_ChIP-Seq_HELA_Human1.32887859
60* TP53_22573176_ChIP-Seq_HFKS_Human1.32420384
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.30916713
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28839431
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27867835
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26488034
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20925153
66MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20840537
67E2F1_18555785_ChIP-Seq_MESCs_Mouse1.19412002
68MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.19086382
69NELFA_20434984_ChIP-Seq_ESCs_Mouse1.18813521
70E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13113900
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12639591
72CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12576026
73HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05764308
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05169057
75GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.04647961
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03842895
77FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02318970
78CBX2_27304074_Chip-Seq_ESCs_Mouse1.01613091
79POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.00346687
80ER_23166858_ChIP-Seq_MCF-7_Human0.97905430
81EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96920878
82FLI1_27457419_Chip-Seq_LIVER_Mouse0.96060870
83P300_19829295_ChIP-Seq_ESCs_Human0.95627731
84CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.89938819
85SOX2_16153702_ChIP-ChIP_HESCs_Human0.88183542
86CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.87993723
87BMI1_23680149_ChIP-Seq_NPCS_Mouse0.87645522
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87150017
89CBP_20019798_ChIP-Seq_JUKART_Human0.87150017
90KLF5_20875108_ChIP-Seq_MESCs_Mouse0.81976612
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.81845799
92E2F1_17053090_ChIP-ChIP_MCF-7_Human0.79699110
93POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.79579423
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79579423
95REST_18959480_ChIP-ChIP_MESCs_Mouse0.79380495
96AR_21572438_ChIP-Seq_LNCaP_Human0.79111909
97PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.78524846
98ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.77508989
99ERG_20887958_ChIP-Seq_HPC-7_Mouse0.77156111
100BCAT_22108803_ChIP-Seq_LS180_Human0.76724254

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.50838393
2MP0008058_abnormal_DNA_repair4.19102086
3MP0002102_abnormal_ear_morphology2.87573119
4MP0000566_synostosis2.80231255
5MP0010094_abnormal_chromosome_stability2.72080701
6MP0006292_abnormal_olfactory_placode2.47432217
7MP0003693_abnormal_embryo_hatching2.32208791
8MP0003880_abnormal_central_pattern2.16387124
9MP0002751_abnormal_autonomic_nervous2.00027874
10MP0002210_abnormal_sex_determination1.99889319
11MP0004147_increased_porphyrin_level1.97093179
12MP0006276_abnormal_autonomic_nervous1.95422384
13MP0002736_abnormal_nociception_after1.92629165
14MP0003111_abnormal_nucleus_morphology1.91014651
15MP0003077_abnormal_cell_cycle1.90844186
16MP0001529_abnormal_vocalization1.90594993
17MP0001929_abnormal_gametogenesis1.82970249
18MP0008057_abnormal_DNA_replication1.76777377
19MP0008932_abnormal_embryonic_tissue1.72009111
20MP0001293_anophthalmia1.67080921
21MP0003718_maternal_effect1.62759355
22MP0008995_early_reproductive_senescence1.61466790
23MP0001968_abnormal_touch/_nociception1.60615179
24MP0003698_abnormal_male_reproductive1.59825891
25MP0003787_abnormal_imprinting1.58326578
26MP0005645_abnormal_hypothalamus_physiol1.57579460
27MP0001145_abnormal_male_reproductive1.54328208
28MP0002160_abnormal_reproductive_system1.52221571
29MP0000653_abnormal_sex_gland1.47502710
30MP0003937_abnormal_limbs/digits/tail_de1.46184715
31MP0002653_abnormal_ependyma_morphology1.43697077
32MP0002234_abnormal_pharynx_morphology1.41870055
33MP0001984_abnormal_olfaction1.41831214
34MP0005423_abnormal_somatic_nervous1.39612433
35MP0004133_heterotaxia1.39363655
36MP0008789_abnormal_olfactory_epithelium1.38153012
37MP0002822_catalepsy1.33337988
38MP0005551_abnormal_eye_electrophysiolog1.31460249
39MP0006035_abnormal_mitochondrial_morpho1.30468436
40MP0000778_abnormal_nervous_system1.28946286
41MP0003121_genomic_imprinting1.28713711
42MP0000631_abnormal_neuroendocrine_gland1.26084424
43MP0003786_premature_aging1.25156890
44MP0005394_taste/olfaction_phenotype1.23423955
45MP0005499_abnormal_olfactory_system1.23423955
46MP0002938_white_spotting1.21752154
47MP0005253_abnormal_eye_physiology1.18452486
48MP0005389_reproductive_system_phenotype1.17941147
49MP0003646_muscle_fatigue1.11142801
50MP0004142_abnormal_muscle_tone1.10495355
51MP0000383_abnormal_hair_follicle1.10401498
52MP0001486_abnormal_startle_reflex1.10108298
53MP0005084_abnormal_gallbladder_morpholo1.09815144
54MP0004957_abnormal_blastocyst_morpholog1.08440906
55MP0005083_abnormal_biliary_tract1.08384015
56MP0009046_muscle_twitch1.07436802
57MP0008007_abnormal_cellular_replicative1.06257990
58MP0002735_abnormal_chemical_nociception1.06116194
59MP0000358_abnormal_cell_content/1.06075382
60MP0001119_abnormal_female_reproductive1.05847966
61MP0003567_abnormal_fetal_cardiomyocyte1.05683402
62MP0001764_abnormal_homeostasis1.05246406
63MP0001286_abnormal_eye_development1.04854313
64MP0001919_abnormal_reproductive_system1.04451855
65MP0002161_abnormal_fertility/fecundity1.00577181
66MP0002233_abnormal_nose_morphology1.00080581
67MP0000955_abnormal_spinal_cord0.97756260
68MP0000049_abnormal_middle_ear0.97028022
69MP0002638_abnormal_pupillary_reflex0.97022126
70MP0003119_abnormal_digestive_system0.96502719
71MP0004145_abnormal_muscle_electrophysio0.96130533
72MP0000372_irregular_coat_pigmentation0.95761745
73MP0010030_abnormal_orbit_morphology0.93792060
74MP0002752_abnormal_somatic_nervous0.89921950
75MP0002184_abnormal_innervation0.89820102
76MP0003861_abnormal_nervous_system0.88490773
77MP0005386_behavior/neurological_phenoty0.85207979
78MP0004924_abnormal_behavior0.85207979
79MP0005410_abnormal_fertilization0.84669356
80MP0001188_hyperpigmentation0.84013556
81MP0009745_abnormal_behavioral_response0.83952491
82MP0002067_abnormal_sensory_capabilities0.83888033
83MP0000026_abnormal_inner_ear0.83714133
84MP0002837_dystrophic_cardiac_calcinosis0.79580627
85MP0001986_abnormal_taste_sensitivity0.79175630
86MP0002272_abnormal_nervous_system0.78488163
87MP0001963_abnormal_hearing_physiology0.77033388
88MP0005391_vision/eye_phenotype0.76982763
89MP0002152_abnormal_brain_morphology0.76426113
90MP0002882_abnormal_neuron_morphology0.76179638
91MP0006072_abnormal_retinal_apoptosis0.75345388
92MP0002557_abnormal_social/conspecific_i0.75286539
93MP0000647_abnormal_sebaceous_gland0.75194802
94MP0002085_abnormal_embryonic_tissue0.75120505
95MP0000467_abnormal_esophagus_morphology0.74934622
96MP0003635_abnormal_synaptic_transmissio0.74698033
97MP0009697_abnormal_copulation0.72967570
98MP0006036_abnormal_mitochondrial_physio0.72315384
99MP0004742_abnormal_vestibular_system0.72247247
100MP0008872_abnormal_physiological_respon0.72125177

Predicted human phenotypes

RankGene SetZ-score
1Duplicated collecting system (HP:0000081)3.03474663
2Volvulus (HP:0002580)3.00941374
3Medial flaring of the eyebrow (HP:0010747)2.87345988
4Retinal dysplasia (HP:0007973)2.84244819
5Abnormality of the renal collecting system (HP:0004742)2.83192160
6Gait imbalance (HP:0002141)2.75248312
7Long foot (HP:0001833)2.72397464
8Congenital primary aphakia (HP:0007707)2.72002281
9Abnormality of the labia minora (HP:0012880)2.65807544
10Pancreatic cysts (HP:0001737)2.56604708
11Molar tooth sign on MRI (HP:0002419)2.56016514
12Abnormality of midbrain morphology (HP:0002418)2.56016514
13Nephrogenic diabetes insipidus (HP:0009806)2.55172034
14Birth length less than 3rd percentile (HP:0003561)2.55103106
15True hermaphroditism (HP:0010459)2.50228327
16Pancreatic fibrosis (HP:0100732)2.49893789
17Patellar aplasia (HP:0006443)2.46684580
18Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.46056716
19Oligodactyly (hands) (HP:0001180)2.43388726
20Chromosomal breakage induced by crosslinking agents (HP:0003221)2.39421530
21Attenuation of retinal blood vessels (HP:0007843)2.38428849
22Aplasia/Hypoplasia of the uvula (HP:0010293)2.32608711
23Colon cancer (HP:0003003)2.29990164
24Lissencephaly (HP:0001339)2.29594699
25Aplasia/Hypoplasia of the patella (HP:0006498)2.29128617
26Hypoplastic pelvis (HP:0008839)2.28982400
27Brushfield spots (HP:0001088)2.28795622
28Polymicrogyria (HP:0002126)2.28232241
29Abnormality of the ileum (HP:0001549)2.27295369
30Type II lissencephaly (HP:0007260)2.26613784
31Genital tract atresia (HP:0001827)2.23839098
32Meckel diverticulum (HP:0002245)2.22716649
333-Methylglutaconic aciduria (HP:0003535)2.22452706
34Chromsome breakage (HP:0040012)2.21417123
35Vaginal atresia (HP:0000148)2.20746128
36Acute lymphatic leukemia (HP:0006721)2.19735951
37Broad-based gait (HP:0002136)2.17680435
38Abnormality of alanine metabolism (HP:0010916)2.14245583
39Hyperalaninemia (HP:0003348)2.14245583
40Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.14245583
41Ectopic kidney (HP:0000086)2.10035268
42Nephronophthisis (HP:0000090)2.09664221
43Abnormality of chromosome stability (HP:0003220)2.09215497
44Preaxial hand polydactyly (HP:0001177)2.08876152
45Increased serum lactate (HP:0002151)2.04481638
46Hepatocellular necrosis (HP:0001404)2.02533903
47Hypoplastic iliac wings (HP:0002866)2.01773628
48Sloping forehead (HP:0000340)2.01176694
49Abnormal lung lobation (HP:0002101)1.99572914
50Small intestinal stenosis (HP:0012848)1.98766460
51Duodenal stenosis (HP:0100867)1.98766460
52Sclerocornea (HP:0000647)1.98315475
53Intestinal atresia (HP:0011100)1.98221436
54Gonadotropin excess (HP:0000837)1.97733742
55Severe muscular hypotonia (HP:0006829)1.97390842
56Large for gestational age (HP:0001520)1.97115486
57Poor coordination (HP:0002370)1.96634388
58Hyperglycinemia (HP:0002154)1.96203620
59Abnormality of the heme biosynthetic pathway (HP:0010472)1.95953069
60Abnormal mitochondria in muscle tissue (HP:0008316)1.94235752
61Postaxial foot polydactyly (HP:0001830)1.90766943
62Increased CSF lactate (HP:0002490)1.90502263
63Acute encephalopathy (HP:0006846)1.90497543
64Lactic acidosis (HP:0003128)1.88994860
65Oligodactyly (HP:0012165)1.86484012
66Multicystic kidney dysplasia (HP:0000003)1.86390624
67Clubbing of toes (HP:0100760)1.85476306
68Acute necrotizing encephalopathy (HP:0006965)1.85372623
69Astigmatism (HP:0000483)1.84907330
70Occipital encephalocele (HP:0002085)1.83877088
71Chronic hepatic failure (HP:0100626)1.83288957
72Hepatic necrosis (HP:0002605)1.79078854
73Abnormality of the metopic suture (HP:0005556)1.78020568
74Abnormality of the renal medulla (HP:0100957)1.77739331
75Bilateral microphthalmos (HP:0007633)1.77301980
76Anencephaly (HP:0002323)1.76795958
77Abnormality of the duodenum (HP:0002246)1.76333461
78Decreased testicular size (HP:0008734)1.75229843
79Broad foot (HP:0001769)1.74861179
80Abnormality of the preputium (HP:0100587)1.74293436
81Neoplasm of the adrenal cortex (HP:0100641)1.73333681
82Absent thumb (HP:0009777)1.72707654
83Bifid tongue (HP:0010297)1.72323476
84Progressive microcephaly (HP:0000253)1.72236283
85Female pseudohermaphroditism (HP:0010458)1.71202323
86Cerebellar dysplasia (HP:0007033)1.71047015
87Aplasia/Hypoplasia of the tongue (HP:0010295)1.70628554
88Prominent metopic ridge (HP:0005487)1.70526963
89Triphalangeal thumb (HP:0001199)1.69925583
90Absent radius (HP:0003974)1.69402562
91Abnormality of the astrocytes (HP:0100707)1.68896318
92Astrocytoma (HP:0009592)1.68896318
93Pachygyria (HP:0001302)1.68881386
94Atrophy/Degeneration involving motor neurons (HP:0007373)1.68664812
95Methylmalonic acidemia (HP:0002912)1.68634855
96Tubulointerstitial nephritis (HP:0001970)1.68513687
97Congenital stationary night blindness (HP:0007642)1.68213066
98Postaxial hand polydactyly (HP:0001162)1.67884915
99Pendular nystagmus (HP:0012043)1.67805501
100Anophthalmia (HP:0000528)1.67663944

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK26.38388353
2MKNK14.37543805
3MAP4K22.84435882
4SRPK12.72698468
5TRIM282.68781908
6ZAK2.60953430
7WNK32.53047126
8MAP3K42.48863137
9TAOK12.44862945
10CDK192.27630597
11FRK2.03581372
12BMPR1B2.02418788
13MAP2K71.87893089
14BUB11.80532416
15TAOK21.74593635
16BCR1.59604668
17CDC71.57172586
18PLK41.55903356
19DYRK21.52223570
20MAPK131.48572445
21CASK1.47910925
22CHEK21.45857058
23INSRR1.43656394
24MAP3K111.43242696
25EPHA41.33526045
26NUAK11.33429831
27CSNK1G31.29853734
28CCNB11.27331626
29ATR1.24797463
30PLK11.24406987
31VRK11.19387186
32BCKDK1.19035197
33MARK11.16367313
34CSNK1G11.16269977
35VRK21.14125636
36DYRK1A1.10259959
37CSNK1A1L1.10086512
38TTK1.06214589
39PLK31.04220185
40NEK11.03646536
41PDK21.02776312
42CSNK1G21.00914791
43DYRK31.00648670
44MAP3K50.98649325
45OXSR10.97412660
46MAP2K30.96933572
47RPS6KA40.93582680
48GRK10.92936198
49NEK20.89825633
50MAP3K30.89363847
51ADRBK20.86536489
52PNCK0.85536909
53AURKA0.82117696
54WEE10.79855949
55PINK10.76777492
56PLK20.72038450
57RPS6KA50.72004383
58TLK10.70187802
59TAOK30.67893380
60CHEK10.67332534
61ATM0.66945914
62ERBB30.66322463
63CDK80.64854067
64WNK40.63497244
65TSSK60.61903597
66BRSK10.55622226
67MINK10.55037706
68STK160.50832967
69BRSK20.49067285
70CDK20.48854402
71ABL20.48672312
72STK390.47889166
73CSNK2A10.46194801
74CDK30.46011780
75AURKB0.44903332
76JAK30.44478495
77CDK10.41862782
78CAMKK20.41321010
79CSNK1A10.40917716
80EIF2AK10.40680040
81CDK70.40464624
82TNIK0.39939427
83CDK40.37613108
84ADRBK10.37154185
85CSNK2A20.36160171
86CDK140.34466461
87MST40.34370458
88CSNK1E0.34046398
89PRKCG0.33947147
90CSNK1D0.31738327
91CDK180.31300131
92CDK11A0.30497004
93CAMK40.28942868
94PAK30.27153280
95PIM20.26981353
96CDK150.25336318
97NME10.25110652
98PRKCI0.25029837
99PKN10.24130425
100MAP2K40.23990841

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034403.41001526
2Base excision repair_Homo sapiens_hsa034103.00612899
3DNA replication_Homo sapiens_hsa030302.99932423
4Non-homologous end-joining_Homo sapiens_hsa034502.97809002
5RNA polymerase_Homo sapiens_hsa030202.97189251
6Mismatch repair_Homo sapiens_hsa034302.84918494
7Fanconi anemia pathway_Homo sapiens_hsa034602.83905020
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.75139707
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.36749982
10Proteasome_Homo sapiens_hsa030502.36363063
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.18184438
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.17566406
13Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.17011470
14One carbon pool by folate_Homo sapiens_hsa006702.13986312
15Basal transcription factors_Homo sapiens_hsa030222.12920814
16RNA transport_Homo sapiens_hsa030132.06049780
17Nucleotide excision repair_Homo sapiens_hsa034202.01580752
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.98801883
19Butanoate metabolism_Homo sapiens_hsa006501.96409467
20SNARE interactions in vesicular transport_Homo sapiens_hsa041301.91414487
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.90489159
22Pyrimidine metabolism_Homo sapiens_hsa002401.82780419
23Propanoate metabolism_Homo sapiens_hsa006401.75123384
24Sulfur relay system_Homo sapiens_hsa041221.68501657
25Cell cycle_Homo sapiens_hsa041101.65948164
26RNA degradation_Homo sapiens_hsa030181.63492558
27Fatty acid elongation_Homo sapiens_hsa000621.59001371
28Lysine degradation_Homo sapiens_hsa003101.53951009
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51510241
30Spliceosome_Homo sapiens_hsa030401.45239596
31Steroid biosynthesis_Homo sapiens_hsa001001.42930803
32Parkinsons disease_Homo sapiens_hsa050121.41024688
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.40054417
34Phototransduction_Homo sapiens_hsa047441.36483213
35Selenocompound metabolism_Homo sapiens_hsa004501.35371649
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.29659991
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.27995933
38Purine metabolism_Homo sapiens_hsa002301.27907215
39Huntingtons disease_Homo sapiens_hsa050161.21138126
40Oxidative phosphorylation_Homo sapiens_hsa001901.20350353
41Nicotine addiction_Homo sapiens_hsa050331.18486104
42Peroxisome_Homo sapiens_hsa041461.16070466
43Taste transduction_Homo sapiens_hsa047421.14424622
44mRNA surveillance pathway_Homo sapiens_hsa030151.07441918
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.04785030
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98862746
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96529612
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92251729
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91265206
50Oocyte meiosis_Homo sapiens_hsa041140.90809249
51Protein export_Homo sapiens_hsa030600.86945215
52Olfactory transduction_Homo sapiens_hsa047400.86866353
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77734604
54Regulation of autophagy_Homo sapiens_hsa041400.77625434
55beta-Alanine metabolism_Homo sapiens_hsa004100.76152305
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71275151
57Pyruvate metabolism_Homo sapiens_hsa006200.66222920
58Fatty acid metabolism_Homo sapiens_hsa012120.64755830
59Metabolic pathways_Homo sapiens_hsa011000.64204100
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64165263
61Tryptophan metabolism_Homo sapiens_hsa003800.64076632
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63785305
63Biosynthesis of amino acids_Homo sapiens_hsa012300.63413913
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60354111
65Nitrogen metabolism_Homo sapiens_hsa009100.55347774
66Alcoholism_Homo sapiens_hsa050340.52907151
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52665665
68p53 signaling pathway_Homo sapiens_hsa041150.51319737
69GABAergic synapse_Homo sapiens_hsa047270.42109970
70Epstein-Barr virus infection_Homo sapiens_hsa051690.40493698
71Hedgehog signaling pathway_Homo sapiens_hsa043400.39799855
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39044807
73Morphine addiction_Homo sapiens_hsa050320.38560727
74Ether lipid metabolism_Homo sapiens_hsa005650.37608596
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36396426
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36084775
77Linoleic acid metabolism_Homo sapiens_hsa005910.34673408
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32880030
79ABC transporters_Homo sapiens_hsa020100.32803405
80Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.31233348
81Arginine and proline metabolism_Homo sapiens_hsa003300.31130795
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.30674598
83Basal cell carcinoma_Homo sapiens_hsa052170.29987068
84Carbon metabolism_Homo sapiens_hsa012000.26847788
85Glycerolipid metabolism_Homo sapiens_hsa005610.26528046
86Cardiac muscle contraction_Homo sapiens_hsa042600.25573942
87Alzheimers disease_Homo sapiens_hsa050100.24987443
88Hippo signaling pathway_Homo sapiens_hsa043900.24083866
89Folate biosynthesis_Homo sapiens_hsa007900.23827191
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.23790628
91Collecting duct acid secretion_Homo sapiens_hsa049660.22175605
92Primary immunodeficiency_Homo sapiens_hsa053400.22044067
93AMPK signaling pathway_Homo sapiens_hsa041520.19146602
94Dopaminergic synapse_Homo sapiens_hsa047280.18410609
95N-Glycan biosynthesis_Homo sapiens_hsa005100.18016123
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.17744217
97Serotonergic synapse_Homo sapiens_hsa047260.17575679
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.17035799
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.16854582
100Fat digestion and absorption_Homo sapiens_hsa049750.16408711

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