ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.49133715
2	fucose catabolic process (GO:0019317)	4.18340900
3	L-fucose metabolic process (GO:0042354)	4.18340900
4	L-fucose catabolic process (GO:0042355)	4.18340900
5	kynurenine metabolic process (GO:0070189)	3.93532932
6	indole-containing compound catabolic process (GO:0042436)	3.85584755
7	indolalkylamine catabolic process (GO:0046218)	3.85584755
8	tryptophan catabolic process (GO:0006569)	3.85584755
9	indolalkylamine metabolic process (GO:0006586)	3.80380169
10	response to pheromone (GO:0019236)	3.66419768
11	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.59904193
12	sulfation (GO:0051923)	3.56871921
13	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.53527748
14	tryptophan metabolic process (GO:0006568)	3.48153959
15	detection of light stimulus involved in sensory perception (GO:0050962)	3.41980123
16	detection of light stimulus involved in visual perception (GO:0050908)	3.41980123
17	neural tube formation (GO:0001841)	3.38304597
18	negative regulation of mast cell activation (GO:0033004)	3.37777488
19	water-soluble vitamin biosynthetic process (GO:0042364)	3.29199338
20	kidney morphogenesis (GO:0060993)	3.25141078
21	DNA deamination (GO:0045006)	3.22843582
22	regulation of hippo signaling (GO:0035330)	3.19547657
23	gamma-aminobutyric acid transport (GO:0015812)	3.15610932
24	cellular ketone body metabolic process (GO:0046950)	3.10153018
25	negative regulation of telomere maintenance (GO:0032205)	3.06968825
26	reflex (GO:0060004)	3.06160191
27	nonmotile primary cilium assembly (GO:0035058)	3.05583930
28	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.02443936
29	platelet dense granule organization (GO:0060155)	3.02115246
30	regulation of mesoderm development (GO:2000380)	2.97245477
31	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.88672084
32	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.88672084
33	regulation of translation, ncRNA-mediated (GO:0045974)	2.88672084
34	protein polyglutamylation (GO:0018095)	2.87992531
35	somite development (GO:0061053)	2.87693655
36	neuronal action potential (GO:0019228)	2.84814753
37	epithelial cilium movement (GO:0003351)	2.81887089
38	indole-containing compound metabolic process (GO:0042430)	2.81150670
39	protein prenylation (GO:0018342)	2.79599876
40	prenylation (GO:0097354)	2.79599876
41	preassembly of GPI anchor in ER membrane (GO:0016254)	2.78879784
42	cornea development in camera-type eye (GO:0061303)	2.77744419
43	ketone body metabolic process (GO:1902224)	2.76711927
44	behavioral response to ethanol (GO:0048149)	2.75194528
45	replication fork processing (GO:0031297)	2.72016686
46	retinal cone cell development (GO:0046549)	2.71027111
47	protein K11-linked deubiquitination (GO:0035871)	2.69906482
48	photoreceptor cell maintenance (GO:0045494)	2.68639558
49	cilium organization (GO:0044782)	2.67748524
50	cilium morphogenesis (GO:0060271)	2.67394101
51	regulation of posttranscriptional gene silencing (GO:0060147)	2.66662614
52	regulation of gene silencing by miRNA (GO:0060964)	2.66662614
53	regulation of gene silencing by RNA (GO:0060966)	2.66662614
54	negative regulation of systemic arterial blood pressure (GO:0003085)	2.65832711
55	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.65588219
56	NADH dehydrogenase complex assembly (GO:0010257)	2.65588219
57	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.65588219
58	spinal cord motor neuron differentiation (GO:0021522)	2.64089031
59	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.63677010
60	adaptation of signaling pathway (GO:0023058)	2.62995271
61	piRNA metabolic process (GO:0034587)	2.62133359
62	axoneme assembly (GO:0035082)	2.61905871
63	interkinetic nuclear migration (GO:0022027)	2.60164280
64	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.60159188
65	regulation of telomere maintenance (GO:0032204)	2.60000381
66	protein complex biogenesis (GO:0070271)	2.59210709
67	positive regulation of fatty acid transport (GO:2000193)	2.58489087
68	cilium assembly (GO:0042384)	2.57667857
69	cilium or flagellum-dependent cell motility (GO:0001539)	2.57613383
70	regulation of action potential (GO:0098900)	2.57093085
71	cell proliferation in forebrain (GO:0021846)	2.56431178
72	reciprocal DNA recombination (GO:0035825)	2.55923470
73	reciprocal meiotic recombination (GO:0007131)	2.55923470
74	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.55693291
75	nephron epithelium morphogenesis (GO:0072088)	2.55075967
76	nephron tubule morphogenesis (GO:0072078)	2.55075967
77	photoreceptor cell development (GO:0042461)	2.54571926
78	cellular biogenic amine catabolic process (GO:0042402)	2.53017145
79	amine catabolic process (GO:0009310)	2.53017145
80	primary amino compound metabolic process (GO:1901160)	2.52194605
81	recombinational repair (GO:0000725)	2.50567794
82	synaptic transmission, cholinergic (GO:0007271)	2.50514442
83	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.50149333
84	double-strand break repair via homologous recombination (GO:0000724)	2.50076304
85	limb bud formation (GO:0060174)	2.49727455
86	rhodopsin mediated signaling pathway (GO:0016056)	2.49657622
87	rRNA catabolic process (GO:0016075)	2.48589227
88	benzene-containing compound metabolic process (GO:0042537)	2.48198628
89	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.47954040
90	proline transport (GO:0015824)	2.47909487
91	establishment of protein localization to Golgi (GO:0072600)	2.46328065
92	oxidative demethylation (GO:0070989)	2.46093641
93	transmission of nerve impulse (GO:0019226)	2.45853025
94	cilium movement (GO:0003341)	2.41053115
95	cellular response to ATP (GO:0071318)	2.39975033
96	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.39928814
97	membrane depolarization during action potential (GO:0086010)	2.39425410
98	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.38363207
99	embryonic epithelial tube formation (GO:0001838)	2.38162468
100	signal peptide processing (GO:0006465)	2.37823520

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.64388809
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.28545799
3	VDR_22108803_ChIP-Seq_LS180_Human	3.16195743
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.84667778
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.77755918
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.77377455
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.67338633
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.50332134
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.50189265
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.33393693
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.23059044
12	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.17722561
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.17667011
14	P300_19829295_ChIP-Seq_ESCs_Human	2.16733109
15	TAF15_26573619_Chip-Seq_HEK293_Human	2.16405802
16	FUS_26573619_Chip-Seq_HEK293_Human	2.11813431
17	EWS_26573619_Chip-Seq_HEK293_Human	2.11547696
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.06416123
19	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.03274263
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.91695409
21	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.88861302
22	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.76720301
23	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.76189066
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.72979799
25	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.67994201
26	SMAD4_21799915_ChIP-Seq_A2780_Human	1.66964158
27	STAT3_23295773_ChIP-Seq_U87_Human	1.65938128
28	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.64847947
29	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.61768228
30	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.60208019
31	BCAT_22108803_ChIP-Seq_LS180_Human	1.57198143
32	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.56858522
33	CBP_20019798_ChIP-Seq_JUKART_Human	1.55497068
34	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.55497068
35	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.54327764
36	* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.53372329
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.53176645
38	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.52021057
39	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.51004751
40	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.49970449
41	IRF1_19129219_ChIP-ChIP_H3396_Human	1.49735178
42	* TCF4_23295773_ChIP-Seq_U87_Human	1.49294531
43	* AR_25329375_ChIP-Seq_VCAP_Human	1.48316308
44	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.47052185
45	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.45900877
46	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.42149246
47	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.42149246
48	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.39681093
49	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.37686797
50	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.36339266
51	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.36006283
52	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.35592451
53	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.35281975
54	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.33392129
55	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.32108836
56	TP53_22573176_ChIP-Seq_HFKS_Human	1.31823283
57	TCF4_22108803_ChIP-Seq_LS180_Human	1.28275576
58	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.27740391
59	NANOG_19829295_ChIP-Seq_ESCs_Human	1.27474744
60	SOX2_19829295_ChIP-Seq_ESCs_Human	1.27474744
61	RUNX2_22187159_ChIP-Seq_PCA_Human	1.26418731
62	REST_21632747_ChIP-Seq_MESCs_Mouse	1.25775295
63	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.24081545
64	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.22904776
65	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.21997662
66	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.20803236
67	AR_21572438_ChIP-Seq_LNCaP_Human	1.20577511
68	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.20486536
69	TP53_16413492_ChIP-PET_HCT116_Human	1.19904569
70	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.19436711
71	RNF2_27304074_Chip-Seq_NSC_Mouse	1.19362589
72	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.17403974
73	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.16961160
74	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.16020037
75	* PRDM14_20953172_ChIP-Seq_ESCs_Human	1.13571712
76	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.12795969
77	* FOXA1_25329375_ChIP-Seq_VCAP_Human	1.11826100
78	* FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.11826100
79	MYC_18940864_ChIP-ChIP_HL60_Human	1.10694675
80	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.09091118
81	P53_22387025_ChIP-Seq_ESCs_Mouse	1.07492595
82	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.07186142
83	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.05913683
84	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.05020285
85	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.04376726
86	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.03225487
87	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.02544469
88	CDX2_22108803_ChIP-Seq_LS180_Human	1.02514656
89	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.02230869
90	AR_20517297_ChIP-Seq_VCAP_Human	1.01807787
91	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.01223295
92	NCOR_22424771_ChIP-Seq_293T_Human	1.00374620
93	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.99282226
94	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.99166395
95	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98799676
96	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.97990483
97	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.97794051
98	JUN_21703547_ChIP-Seq_K562_Human	0.97712129
99	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.97135018
100	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.96716238

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.65148834
2	MP0002837_dystrophic_cardiac_calcinosis	2.90915634
3	MP0003195_calcinosis	2.65706921
4	MP0002102_abnormal_ear_morphology	2.60427651
5	MP0008877_abnormal_DNA_methylation	2.56025602
6	MP0005551_abnormal_eye_electrophysiolog	2.51932002
7	MP0001968_abnormal_touch/_nociception	2.29863153
8	MP0006072_abnormal_retinal_apoptosis	2.27751712
9	MP0006292_abnormal_olfactory_placode	2.24875347
10	MP0004885_abnormal_endolymph	2.18774549
11	MP0002938_white_spotting	2.09795594
12	MP0003646_muscle_fatigue	2.08867062
13	MP0005646_abnormal_pituitary_gland	2.01603343
14	MP0004142_abnormal_muscle_tone	1.98750350
15	MP0009046_muscle_twitch	1.95322578
16	MP0009745_abnormal_behavioral_response	1.91485395
17	MP0005253_abnormal_eye_physiology	1.88801641
18	MP0001485_abnormal_pinna_reflex	1.88110842
19	MP0002736_abnormal_nociception_after	1.84125132
20	MP0005174_abnormal_tail_pigmentation	1.83266965
21	MP0008872_abnormal_physiological_respon	1.77121124
22	MP0003136_yellow_coat_color	1.76212086
23	MP0002653_abnormal_ependyma_morphology	1.75454098
24	MP0003787_abnormal_imprinting	1.72314506
25	MP0000427_abnormal_hair_cycle	1.66224866
26	MP0001501_abnormal_sleep_pattern	1.63962174
27	MP0006276_abnormal_autonomic_nervous	1.61864737
28	MP0002272_abnormal_nervous_system	1.61518938
29	MP0000631_abnormal_neuroendocrine_gland	1.60448963
30	MP0002876_abnormal_thyroid_physiology	1.59666072
31	MP0001486_abnormal_startle_reflex	1.58815440
32	MP0004133_heterotaxia	1.55776620
33	MP0000372_irregular_coat_pigmentation	1.55615339
34	MP0004043_abnormal_pH_regulation	1.52279348
35	MP0003880_abnormal_central_pattern	1.51731692
36	MP0003011_delayed_dark_adaptation	1.50469062
37	MP0002735_abnormal_chemical_nociception	1.47041042
38	MP0000383_abnormal_hair_follicle	1.45403379
39	MP0004145_abnormal_muscle_electrophysio	1.44738195
40	MP0002638_abnormal_pupillary_reflex	1.39978192
41	MP0001986_abnormal_taste_sensitivity	1.36781079
42	MP0002572_abnormal_emotion/affect_behav	1.36055945
43	MP0004147_increased_porphyrin_level	1.34629361
44	MP0003890_abnormal_embryonic-extraembry	1.34137568
45	MP0005645_abnormal_hypothalamus_physiol	1.32401792
46	MP0002557_abnormal_social/conspecific_i	1.27836850
47	MP0002928_abnormal_bile_duct	1.24112122
48	MP0004215_abnormal_myocardial_fiber	1.23904889
49	MP0002064_seizures	1.23721697
50	MP0005386_behavior/neurological_phenoty	1.18646760
51	MP0004924_abnormal_behavior	1.18646760
52	MP0008775_abnormal_heart_ventricle	1.17373732
53	MP0003283_abnormal_digestive_organ	1.16917115
54	MP0010386_abnormal_urinary_bladder	1.14854529
55	MP0002095_abnormal_skin_pigmentation	1.14202946
56	MP0002067_abnormal_sensory_capabilities	1.12520930
57	MP0005084_abnormal_gallbladder_morpholo	1.10438214
58	MP0001970_abnormal_pain_threshold	1.10171832
59	MP0005389_reproductive_system_phenotype	1.08701429
60	MP0008875_abnormal_xenobiotic_pharmacok	1.08673054
61	MP0003635_abnormal_synaptic_transmissio	1.07421396
62	MP0002063_abnormal_learning/memory/cond	1.07230285
63	MP0000230_abnormal_systemic_arterial	1.06835947
64	MP0005195_abnormal_posterior_eye	1.06595410
65	MP0002160_abnormal_reproductive_system	1.04729650
66	MP0003718_maternal_effect	1.02920212
67	MP0002234_abnormal_pharynx_morphology	1.02276499
68	MP0003137_abnormal_impulse_conducting	1.01579915
69	MP0001984_abnormal_olfaction	1.01337116
70	MP0002733_abnormal_thermal_nociception	1.00913451
71	MP0002138_abnormal_hepatobiliary_system	0.98699016
72	MP0000778_abnormal_nervous_system	0.98658957
73	MP0004742_abnormal_vestibular_system	0.96980299
74	MP0002734_abnormal_mechanical_nocicepti	0.94846078
75	MP0002751_abnormal_autonomic_nervous	0.94029379
76	MP0001529_abnormal_vocalization	0.93977814
77	MP0001440_abnormal_grooming_behavior	0.91704486
78	MP0003937_abnormal_limbs/digits/tail_de	0.88307614
79	MP0001919_abnormal_reproductive_system	0.87530431
80	MP0001963_abnormal_hearing_physiology	0.86710275
81	MP0003119_abnormal_digestive_system	0.86535111
82	MP0002909_abnormal_adrenal_gland	0.86372403
83	MP0001905_abnormal_dopamine_level	0.85543699
84	MP0002752_abnormal_somatic_nervous	0.85384288
85	MP0000049_abnormal_middle_ear	0.85225416
86	MP0003252_abnormal_bile_duct	0.84368247
87	MP0000026_abnormal_inner_ear	0.81924680
88	MP0000647_abnormal_sebaceous_gland	0.80810062
89	MP0005171_absent_coat_pigmentation	0.79416731
90	MP0002184_abnormal_innervation	0.78186115
91	MP0001324_abnormal_eye_pigmentation	0.77689183
92	MP0001502_abnormal_circadian_rhythm	0.75566577
93	MP0002254_reproductive_system_inflammat	0.74278609
94	MP0001293_anophthalmia	0.73774842
95	MP0008058_abnormal_DNA_repair	0.73140055
96	MP0004085_abnormal_heartbeat	0.71783936
97	MP0005391_vision/eye_phenotype	0.71744929
98	MP0003121_genomic_imprinting	0.71449219
99	MP0000538_abnormal_urinary_bladder	0.71287904
100	MP0000371_diluted_coat_color	0.69776612

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.78919768
2	Pancreatic fibrosis (HP:0100732)	4.30968444
3	True hermaphroditism (HP:0010459)	4.20442099
4	Abnormality of midbrain morphology (HP:0002418)	4.13651688
5	Molar tooth sign on MRI (HP:0002419)	4.13651688
6	Congenital stationary night blindness (HP:0007642)	3.84838065
7	Nephronophthisis (HP:0000090)	3.82926572
8	Abnormality of the renal cortex (HP:0011035)	3.38823964
9	Abnormality of the renal medulla (HP:0100957)	3.32542021
10	Medial flaring of the eyebrow (HP:0010747)	3.21828664
11	Type II lissencephaly (HP:0007260)	3.16249187
12	Hyperventilation (HP:0002883)	3.07776731
13	Chronic hepatic failure (HP:0100626)	3.03003030
14	Abolished electroretinogram (ERG) (HP:0000550)	3.02420589
15	Attenuation of retinal blood vessels (HP:0007843)	2.95178032
16	Genetic anticipation (HP:0003743)	2.90638276
17	Cystic liver disease (HP:0006706)	2.82827118
18	Tubular atrophy (HP:0000092)	2.80415662
19	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.77756961
20	Gaze-evoked nystagmus (HP:0000640)	2.73756105
21	Progressive cerebellar ataxia (HP:0002073)	2.73469923
22	Gait imbalance (HP:0002141)	2.59578584
23	Abnormality of alanine metabolism (HP:0010916)	2.55003120
24	Hyperalaninemia (HP:0003348)	2.55003120
25	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.55003120
26	Congenital primary aphakia (HP:0007707)	2.53019133
27	Sclerocornea (HP:0000647)	2.52543086
28	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.52495121
29	Increased corneal curvature (HP:0100692)	2.48999608
30	Keratoconus (HP:0000563)	2.48999608
31	Pendular nystagmus (HP:0012043)	2.47958540
32	Decreased circulating renin level (HP:0003351)	2.45177299
33	Protruding tongue (HP:0010808)	2.44902083
34	Hypoplasia of the pons (HP:0012110)	2.44463582
35	Inability to walk (HP:0002540)	2.43357103
36	Renal cortical cysts (HP:0000803)	2.42638099
37	Abnormality of the pons (HP:0007361)	2.39375789
38	Genital tract atresia (HP:0001827)	2.37581123
39	Polydipsia (HP:0001959)	2.36163667
40	Abnormal drinking behavior (HP:0030082)	2.36163667
41	Hypothermia (HP:0002045)	2.31490970
42	Congenital hepatic fibrosis (HP:0002612)	2.30332723
43	Nephrogenic diabetes insipidus (HP:0009806)	2.29784478
44	Vaginal atresia (HP:0000148)	2.29435263
45	Congenital, generalized hypertrichosis (HP:0004540)	2.28275445
46	Cerebellar dysplasia (HP:0007033)	2.28214444
47	Furrowed tongue (HP:0000221)	2.28032371
48	Abnormal rod and cone electroretinograms (HP:0008323)	2.24975314
49	Decreased central vision (HP:0007663)	2.23299867
50	Broad-based gait (HP:0002136)	2.20493629
51	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.20116543
52	Anencephaly (HP:0002323)	2.18861192
53	Colon cancer (HP:0003003)	2.13381204
54	Chorioretinal atrophy (HP:0000533)	2.13177718
55	Hemiparesis (HP:0001269)	2.13076849
56	Male pseudohermaphroditism (HP:0000037)	2.12199956
57	Progressive inability to walk (HP:0002505)	2.12135621
58	Absent/shortened dynein arms (HP:0200106)	2.11799459
59	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.11799459
60	Fair hair (HP:0002286)	2.11060872
61	Lissencephaly (HP:0001339)	2.10922690
62	Clumsiness (HP:0002312)	2.09517108
63	Stomach cancer (HP:0012126)	2.08901247
64	Intestinal atresia (HP:0011100)	2.08527646
65	Febrile seizures (HP:0002373)	2.08001808
66	Postaxial foot polydactyly (HP:0001830)	2.06196499
67	Large for gestational age (HP:0001520)	2.03719560
68	Bony spicule pigmentary retinopathy (HP:0007737)	2.02030084
69	Congenital sensorineural hearing impairment (HP:0008527)	1.98188384
70	Patellar aplasia (HP:0006443)	1.97030543
71	Short tibia (HP:0005736)	1.94015704
72	Aplasia/Hypoplasia of the patella (HP:0006498)	1.91331309
73	Absent speech (HP:0001344)	1.90929280
74	Methylmalonic acidemia (HP:0002912)	1.89484583
75	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.88497578
76	Poor coordination (HP:0002370)	1.85375598
77	Optic nerve hypoplasia (HP:0000609)	1.84839625
78	Postaxial hand polydactyly (HP:0001162)	1.84173016
79	Concave nail (HP:0001598)	1.80997434
80	Polyuria (HP:0000103)	1.79110881
81	Pachygyria (HP:0001302)	1.77270264
82	Small hand (HP:0200055)	1.76442747
83	Abnormality of the labia minora (HP:0012880)	1.75495995
84	Preaxial hand polydactyly (HP:0001177)	1.75375005
85	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.74216127
86	Retinal dysplasia (HP:0007973)	1.72617606
87	Abnormal biliary tract physiology (HP:0012439)	1.72380697
88	Bile duct proliferation (HP:0001408)	1.72380697
89	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.71814744
90	Widely spaced teeth (HP:0000687)	1.70335604
91	Dialeptic seizures (HP:0011146)	1.69734124
92	Dandy-Walker malformation (HP:0001305)	1.66815576
93	Generalized hypopigmentation of hair (HP:0011358)	1.65540319
94	Severe muscular hypotonia (HP:0006829)	1.65272782
95	Asplenia (HP:0001746)	1.64887040
96	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.64692286
97	Retinitis pigmentosa (HP:0000510)	1.60865146
98	Short foot (HP:0001773)	1.60081572
99	Specific learning disability (HP:0001328)	1.59649490
100	Bilateral microphthalmos (HP:0007633)	1.59372831

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.31203191
2	BMPR1B	3.28917790
3	MAP4K2	3.14338379
4	ACVR1B	2.78009092
5	ADRBK2	2.77327765
6	WNK3	2.62000587
7	ZAK	2.49819929
8	NUAK1	2.47135870
9	TLK1	2.43642400
10	GRK1	2.37036759
11	TAOK3	2.16489916
12	CASK	2.07052414
13	WNK4	1.97583515
14	INSRR	1.85259546
15	MAPK13	1.76111435
16	MKNK2	1.69411716
17	PINK1	1.55645211
18	MAP3K4	1.55213597
19	OXSR1	1.47330068
20	EPHA3	1.44615027
21	TXK	1.41909462
22	TNIK	1.40239165
23	DAPK2	1.39764791
24	STK39	1.39370774
25	PAK3	1.35719673
26	ADRBK1	1.21455251
27	PNCK	1.16583828
28	CAMKK2	1.16516162
29	BRSK2	1.14583311
30	TGFBR1	1.06098854
31	STK38L	1.03840168
32	TIE1	0.99831980
33	MUSK	0.96875740
34	PRKCE	0.91325607
35	TAF1	0.90875662
36	AKT3	0.89946638
37	PRKCG	0.87603149
38	VRK1	0.85649165
39	PIK3CA	0.85625839
40	IRAK1	0.82290132
41	MAPK15	0.82197509
42	DYRK2	0.79865193
43	TEC	0.79428951
44	TRIM28	0.78661554
45	MKNK1	0.76798098
46	FGFR2	0.75886326
47	MAPKAPK5	0.75717234
48	MARK1	0.75543474
49	PKN1	0.75474269
50	NTRK3	0.72787885
51	PHKG2	0.72560126
52	PHKG1	0.72560126
53	NLK	0.70229728
54	STK3	0.69399172
55	PTK2B	0.66291330
56	ERBB3	0.60329696
57	CSNK1G2	0.59986164
58	MAP2K7	0.58258285
59	LATS1	0.57594873
60	GRK7	0.57398636
61	FLT3	0.57025790
62	WEE1	0.55496293
63	CSNK1G1	0.53914459
64	PLK2	0.53333527
65	KIT	0.53274533
66	RPS6KA5	0.52819634
67	IKBKB	0.52584236
68	MAP2K6	0.51964326
69	FER	0.50864725
70	SGK2	0.50362006
71	OBSCN	0.50327052
72	CAMK2A	0.50205514
73	PLK4	0.45528758
74	PLK3	0.43890193
75	CSNK1A1L	0.43437440
76	EPHA4	0.42768723
77	ERBB2	0.42368452
78	STK11	0.41987047
79	NEK2	0.41530235
80	PRKACA	0.41002547
81	PRKCQ	0.40282113
82	STK16	0.40178126
83	CCNB1	0.39111719
84	CSNK1G3	0.38591744
85	CAMK1	0.38213044
86	CSNK1A1	0.37654594
87	PRKAA2	0.36549401
88	NTRK2	0.36268970
89	BCR	0.35821665
90	GRK5	0.35130598
91	CSNK1D	0.33624291
92	TRPM7	0.33351225
93	IGF1R	0.33294044
94	CHUK	0.32396579
95	VRK2	0.32031189
96	MAPKAPK3	0.31673156
97	ATR	0.29676656
98	SGK223	0.28800803
99	SGK494	0.28800803
100	PRKG1	0.28152998

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.01484487
2	Linoleic acid metabolism_Homo sapiens_hsa00591	2.68194527
3	Nicotine addiction_Homo sapiens_hsa05033	2.54855407
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.54357158
5	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.48309969
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.33772170
7	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.20423303
8	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.15371893
9	Butanoate metabolism_Homo sapiens_hsa00650	2.12777112
10	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.08440850
11	Homologous recombination_Homo sapiens_hsa03440	2.03950017
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.94232224
13	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.93523186
14	Selenocompound metabolism_Homo sapiens_hsa00450	1.90452319
15	Caffeine metabolism_Homo sapiens_hsa00232	1.89861237
16	Ether lipid metabolism_Homo sapiens_hsa00565	1.89612522
17	Tryptophan metabolism_Homo sapiens_hsa00380	1.83764119
18	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.80125628
19	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.79789285
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.78062333
21	Basal transcription factors_Homo sapiens_hsa03022	1.67548275
22	Taste transduction_Homo sapiens_hsa04742	1.65686144
23	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.64426930
24	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.64405510
25	Olfactory transduction_Homo sapiens_hsa04740	1.47755529
26	Morphine addiction_Homo sapiens_hsa05032	1.46242596
27	Protein export_Homo sapiens_hsa03060	1.42854399
28	Oxidative phosphorylation_Homo sapiens_hsa00190	1.39139202
29	RNA polymerase_Homo sapiens_hsa03020	1.33853169
30	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.33504913
31	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.33092751
32	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.23638083
33	ABC transporters_Homo sapiens_hsa02010	1.22733846
34	Circadian entrainment_Homo sapiens_hsa04713	1.20473426
35	Insulin secretion_Homo sapiens_hsa04911	1.17735918
36	Propanoate metabolism_Homo sapiens_hsa00640	1.17555770
37	Chemical carcinogenesis_Homo sapiens_hsa05204	1.14991515
38	RNA degradation_Homo sapiens_hsa03018	1.14895730
39	GABAergic synapse_Homo sapiens_hsa04727	1.13723381
40	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.13589398
41	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.12011916
42	Glutamatergic synapse_Homo sapiens_hsa04724	1.09408337
43	Serotonergic synapse_Homo sapiens_hsa04726	1.07393142
44	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.07076850
45	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.04199612
46	Retinol metabolism_Homo sapiens_hsa00830	1.03364249
47	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.99639661
48	Peroxisome_Homo sapiens_hsa04146	0.94289139
49	Regulation of autophagy_Homo sapiens_hsa04140	0.93562966
50	Salivary secretion_Homo sapiens_hsa04970	0.92813121
51	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.92277875
52	Parkinsons disease_Homo sapiens_hsa05012	0.88943946
53	Calcium signaling pathway_Homo sapiens_hsa04020	0.86513689
54	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.84599094
55	One carbon pool by folate_Homo sapiens_hsa00670	0.84315053
56	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.82102978
57	Cardiac muscle contraction_Homo sapiens_hsa04260	0.81285013
58	beta-Alanine metabolism_Homo sapiens_hsa00410	0.79804767
59	Asthma_Homo sapiens_hsa05310	0.75814153
60	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.74967460
61	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.73733895
62	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.73492486
63	Glycerolipid metabolism_Homo sapiens_hsa00561	0.73188779
64	Circadian rhythm_Homo sapiens_hsa04710	0.67942042
65	Histidine metabolism_Homo sapiens_hsa00340	0.66501915
66	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.65362524
67	Huntingtons disease_Homo sapiens_hsa05016	0.65189263
68	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.64478740
69	Primary immunodeficiency_Homo sapiens_hsa05340	0.59903498
70	Sulfur metabolism_Homo sapiens_hsa00920	0.59368706
71	Dopaminergic synapse_Homo sapiens_hsa04728	0.58490473
72	Long-term depression_Homo sapiens_hsa04730	0.57275512
73	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.56575120
74	Alzheimers disease_Homo sapiens_hsa05010	0.54789382
75	Non-homologous end-joining_Homo sapiens_hsa03450	0.53839238
76	cAMP signaling pathway_Homo sapiens_hsa04024	0.52955838
77	Cholinergic synapse_Homo sapiens_hsa04725	0.51171116
78	Purine metabolism_Homo sapiens_hsa00230	0.50873120
79	Amphetamine addiction_Homo sapiens_hsa05031	0.50712570
80	Fat digestion and absorption_Homo sapiens_hsa04975	0.50224073
81	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.49643774
82	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.49244606
83	Renin secretion_Homo sapiens_hsa04924	0.49229292
84	Type I diabetes mellitus_Homo sapiens_hsa04940	0.48010493
85	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.47445972
86	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.45593643
87	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.44904669
88	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.44467280
89	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.44391449
90	Mineral absorption_Homo sapiens_hsa04978	0.42380793
91	Basal cell carcinoma_Homo sapiens_hsa05217	0.42116611
92	Collecting duct acid secretion_Homo sapiens_hsa04966	0.41910550
93	Metabolic pathways_Homo sapiens_hsa01100	0.41077943
94	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.39400554
95	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.39384001
96	Cocaine addiction_Homo sapiens_hsa05030	0.39312202
97	Lysine degradation_Homo sapiens_hsa00310	0.38757996
98	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.38334277
99	Gastric acid secretion_Homo sapiens_hsa04971	0.34966404
100	Sulfur relay system_Homo sapiens_hsa04122	0.34667237

ZNF347

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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