ZNF35

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)5.55999894
2RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)5.55999894
3homocysteine metabolic process (GO:0050667)5.19695214
4folic acid-containing compound biosynthetic process (GO:0009396)5.11244153
5CENP-A containing nucleosome assembly (GO:0034080)4.55481713
6mitochondrial RNA metabolic process (GO:0000959)4.51292260
7chromatin remodeling at centromere (GO:0031055)4.50971851
8microtubule nucleation (GO:0007020)4.45716891
9L-serine metabolic process (GO:0006563)4.26494732
10rRNA methylation (GO:0031167)4.18277232
11rRNA modification (GO:0000154)3.91536372
12IMP biosynthetic process (GO:0006188)3.88950624
13pseudouridine synthesis (GO:0001522)3.87768950
14ribosome biogenesis (GO:0042254)3.80698958
15negative regulation of DNA biosynthetic process (GO:2000279)3.75898002
16histone exchange (GO:0043486)3.75321233
17inner ear receptor cell development (GO:0060119)3.66945146
18DNA replication-independent nucleosome organization (GO:0034724)3.66343867
19DNA replication-independent nucleosome assembly (GO:0006336)3.66343867
20regulation of centriole replication (GO:0046599)3.58171545
21sulfur amino acid catabolic process (GO:0000098)3.56606342
22kinetochore assembly (GO:0051382)3.52050700
23kinetochore organization (GO:0051383)3.50417703
24pteridine-containing compound biosynthetic process (GO:0042559)3.42664988
25adenosine metabolic process (GO:0046085)3.41781802
26IMP metabolic process (GO:0046040)3.38058368
27epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.37526934
28DNA double-strand break processing (GO:0000729)3.36536681
29mitochondrial respiratory chain complex I assembly (GO:0032981)3.34655273
30NADH dehydrogenase complex assembly (GO:0010257)3.34655273
31mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.34655273
32proteasome assembly (GO:0043248)3.32407144
33DNA ligation (GO:0006266)3.27655560
34cellular protein complex localization (GO:0034629)3.26799238
35tRNA processing (GO:0008033)3.25212215
36regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.24149864
37regulation of mitotic spindle checkpoint (GO:1903504)3.24149864
38nuclear pore complex assembly (GO:0051292)3.20555104
39protein-cofactor linkage (GO:0018065)3.15104252
40tRNA modification (GO:0006400)3.11668747
41cysteine metabolic process (GO:0006534)3.09154153
42DNA catabolic process, exonucleolytic (GO:0000738)3.05644155
43regulation of plasminogen activation (GO:0010755)3.03668124
44replication fork processing (GO:0031297)3.00750487
45negative regulation of keratinocyte proliferation (GO:0010839)2.98540071
46tRNA metabolic process (GO:0006399)2.96163935
47purine nucleotide salvage (GO:0032261)2.96014583
48serine family amino acid biosynthetic process (GO:0009070)2.94222975
49mitochondrial respiratory chain complex assembly (GO:0033108)2.93791754
50negative regulation of Ras GTPase activity (GO:0034261)2.93245399
51negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.92360653
52inner mitochondrial membrane organization (GO:0007007)2.91333137
53negative regulation of telomerase activity (GO:0051974)2.90739768
54protein complex localization (GO:0031503)2.89029226
55protein complex biogenesis (GO:0070271)2.87193607
56transcription from mitochondrial promoter (GO:0006390)2.86812790
57protein localization to chromosome, centromeric region (GO:0071459)2.86204923
58single strand break repair (GO:0000012)2.84712963
59ATP-dependent chromatin remodeling (GO:0043044)2.84495618
60alternative mRNA splicing, via spliceosome (GO:0000380)2.82800859
61non-recombinational repair (GO:0000726)2.79222640
62double-strand break repair via nonhomologous end joining (GO:0006303)2.79222640
63regulation of centrosome cycle (GO:0046605)2.78139740
64tetrahydrofolate metabolic process (GO:0046653)2.75974142
65establishment of integrated proviral latency (GO:0075713)2.72450783
66regulation of DNA endoreduplication (GO:0032875)2.72041413
67negative regulation of DNA-dependent DNA replication (GO:2000104)2.69776533
68tRNA methylation (GO:0030488)2.69184030
69cartilage morphogenesis (GO:0060536)2.68716588
70maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.68599921
71protein localization to kinetochore (GO:0034501)2.68429580
72regulation of centrosome duplication (GO:0010824)2.66845479
73DNA strand renaturation (GO:0000733)2.66460896
74DNA replication checkpoint (GO:0000076)2.65992442
75chaperone-mediated protein transport (GO:0072321)2.63319711
76folic acid-containing compound metabolic process (GO:0006760)2.61785682
77nuclear pore organization (GO:0006999)2.60636173
78ncRNA processing (GO:0034470)2.60388006
79viral mRNA export from host cell nucleus (GO:0046784)2.60243447
80mitotic metaphase plate congression (GO:0007080)2.59797322
81polyamine biosynthetic process (GO:0006596)2.59146631
82DNA replication-dependent nucleosome assembly (GO:0006335)2.58397584
83DNA replication-dependent nucleosome organization (GO:0034723)2.58397584
84regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.58196753
85ribosome assembly (GO:0042255)2.57153991
86mitotic sister chromatid cohesion (GO:0007064)2.56439489
87activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.54491994
88cellular component biogenesis (GO:0044085)2.54369637
89regulation of helicase activity (GO:0051095)2.54187104
90sulfur amino acid biosynthetic process (GO:0000097)2.53852329
91cochlea development (GO:0090102)2.53425615
92ribonucleoprotein complex biogenesis (GO:0022613)2.52438558
93histone H4-K12 acetylation (GO:0043983)2.51624406
94behavioral response to nicotine (GO:0035095)2.51208510
95cullin deneddylation (GO:0010388)2.50650837
96chromosome condensation (GO:0030261)2.50575577
97metaphase plate congression (GO:0051310)2.49257639
98rRNA processing (GO:0006364)2.46839821
99regulation of spindle checkpoint (GO:0090231)2.46797727
100spliceosomal snRNP assembly (GO:0000387)2.46655171

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.56569405
2E2F7_22180533_ChIP-Seq_HELA_Human5.45331253
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.11070899
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.70340853
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.50582749
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.13601700
7ELK1_19687146_ChIP-ChIP_HELA_Human2.90930086
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.86575600
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.79374813
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.79172386
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.75477977
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.68591009
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.59982167
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.44378873
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.39212801
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.38500452
17KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.32766079
18AR_21909140_ChIP-Seq_LNCAP_Human2.24886836
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.13199692
20FUS_26573619_Chip-Seq_HEK293_Human2.10424270
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.08358497
22PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04301168
23PADI4_21655091_ChIP-ChIP_MCF-7_Human2.00947044
24POU5F1_16153702_ChIP-ChIP_HESCs_Human2.00162233
25YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.00080065
26VDR_23849224_ChIP-Seq_CD4+_Human2.00024205
27EWS_26573619_Chip-Seq_HEK293_Human1.98504723
28E2F1_21310950_ChIP-Seq_MCF-7_Human1.96901653
29MYC_19079543_ChIP-ChIP_MESCs_Mouse1.84977985
30MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84872243
31FOXP3_21729870_ChIP-Seq_TREG_Human1.83442312
32ZNF274_21170338_ChIP-Seq_K562_Hela1.83406188
33DCP1A_22483619_ChIP-Seq_HELA_Human1.76285124
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.74007379
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.73676704
36MYC_18358816_ChIP-ChIP_MESCs_Mouse1.72373582
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.72068006
38XRN2_22483619_ChIP-Seq_HELA_Human1.70713049
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.66528255
40VDR_22108803_ChIP-Seq_LS180_Human1.64509082
41GABP_19822575_ChIP-Seq_HepG2_Human1.54515353
42TTF2_22483619_ChIP-Seq_HELA_Human1.51665837
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43753535
44TP63_19390658_ChIP-ChIP_HaCaT_Human1.42022202
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.41756901
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.39406858
47NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.37597701
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35203955
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34439982
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.34208342
51ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.30853901
52SOX2_16153702_ChIP-ChIP_HESCs_Human1.29761015
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28866686
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.27832657
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.27075126
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26831277
57E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20150745
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.19594962
59NANOG_16153702_ChIP-ChIP_HESCs_Human1.17513613
60P300_19829295_ChIP-Seq_ESCs_Human1.12748703
61* MYC_18940864_ChIP-ChIP_HL60_Human1.09456633
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09138760
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.07262825
64EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.05288328
65NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01610078
66ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01194134
67IGF1R_20145208_ChIP-Seq_DFB_Human1.00750137
68PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00115207
69CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98549387
70HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97075305
71ELK1_22589737_ChIP-Seq_MCF10A_Human0.96776724
72HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96128818
73FLI1_27457419_Chip-Seq_LIVER_Mouse0.94919081
74* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94503069
75KDM5A_27292631_Chip-Seq_BREAST_Human0.94264397
76SOX17_20123909_ChIP-Seq_XEN_Mouse0.93650601
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90271079
78TP53_22573176_ChIP-Seq_HFKS_Human0.89340683
79SOX2_18555785_ChIP-Seq_MESCs_Mouse0.87593515
80TFEB_21752829_ChIP-Seq_HELA_Human0.87451240
81YY1_21170310_ChIP-Seq_MESCs_Mouse0.84471500
82SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.84410633
83CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.83984290
84ZFX_18555785_ChIP-Seq_MESCs_Mouse0.82349533
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.82226360
86CDX2_22108803_ChIP-Seq_LS180_Human0.81739754
87SOX9_26525672_Chip-Seq_HEART_Mouse0.81480800
88ELF1_17652178_ChIP-ChIP_JURKAT_Human0.81410041
89RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.80179896
90EZH2_27294783_Chip-Seq_NPCs_Mouse0.78287296
91SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.78076410
92CTBP1_25329375_ChIP-Seq_LNCAP_Human0.77835177
93CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.77560989
94TOP2B_26459242_ChIP-Seq_MCF-7_Human0.74665817
95SALL4_22934838_ChIP-ChIP_CD34+_Human0.73846408
96PCGF2_27294783_Chip-Seq_NPCs_Mouse0.73776268
97FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.72582165
98TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.72373053
99KLF5_20875108_ChIP-Seq_MESCs_Mouse0.72014135
100HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.71818897

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair3.18720104
2MP0008057_abnormal_DNA_replication3.01740134
3MP0002938_white_spotting2.98802355
4MP0003111_abnormal_nucleus_morphology2.86421834
5MP0003890_abnormal_embryonic-extraembry2.76748858
6MP0000516_abnormal_urinary_system2.62450985
7MP0005367_renal/urinary_system_phenotyp2.62450985
8MP0010094_abnormal_chromosome_stability2.57705871
9MP0004957_abnormal_blastocyst_morpholog2.46845302
10MP0003693_abnormal_embryo_hatching2.46047280
11MP0003077_abnormal_cell_cycle2.23336926
12MP0003941_abnormal_skin_development2.20461651
13MP0008932_abnormal_embryonic_tissue2.17997426
14MP0001661_extended_life_span2.14600455
15MP0008007_abnormal_cellular_replicative1.98349958
16MP0006292_abnormal_olfactory_placode1.90068159
17MP0002638_abnormal_pupillary_reflex1.78470127
18MP0003705_abnormal_hypodermis_morpholog1.70166137
19MP0003950_abnormal_plasma_membrane1.68912042
20MP0008995_early_reproductive_senescence1.67723005
21MP0005084_abnormal_gallbladder_morpholo1.65575971
22MP0003786_premature_aging1.63689996
23MP0003718_maternal_effect1.57497959
24MP0001293_anophthalmia1.54608294
25MP0009697_abnormal_copulation1.39959942
26MP0001529_abnormal_vocalization1.39141658
27MP0006072_abnormal_retinal_apoptosis1.38296142
28MP0004233_abnormal_muscle_weight1.38113146
29MP0002084_abnormal_developmental_patter1.35629247
30MP0002295_abnormal_pulmonary_circulatio1.35167339
31MP0008789_abnormal_olfactory_epithelium1.34011975
32MP0002095_abnormal_skin_pigmentation1.31353429
33MP0005646_abnormal_pituitary_gland1.27760524
34MP0000647_abnormal_sebaceous_gland1.26840093
35MP0003937_abnormal_limbs/digits/tail_de1.26106153
36MP0003186_abnormal_redox_activity1.21969562
37MP0004133_heterotaxia1.21655071
38MP0001188_hyperpigmentation1.21138908
39MP0002254_reproductive_system_inflammat1.20565719
40MP0001764_abnormal_homeostasis1.19694221
41MP0008877_abnormal_DNA_methylation1.18587144
42MP0000013_abnormal_adipose_tissue1.18298963
43MP0003880_abnormal_central_pattern1.18192204
44MP0005670_abnormal_white_adipose1.16387129
45MP0002160_abnormal_reproductive_system1.16304285
46MP0005253_abnormal_eye_physiology1.15975183
47MP0005380_embryogenesis_phenotype1.14947973
48MP0001672_abnormal_embryogenesis/_devel1.14947973
49MP0003984_embryonic_growth_retardation1.13408827
50MP0002088_abnormal_embryonic_growth/wei1.12819795
51MP0001177_atelectasis1.11389437
52MP0006276_abnormal_autonomic_nervous1.09979124
53MP0000778_abnormal_nervous_system1.09288514
54MP0001697_abnormal_embryo_size1.08142287
55MP0002085_abnormal_embryonic_tissue1.08001584
56MP0003315_abnormal_perineum_morphology1.07777565
57MP0002697_abnormal_eye_size1.07352875
58MP0003942_abnormal_urinary_system1.05797702
59MP0002396_abnormal_hematopoietic_system1.04811039
60MP0003755_abnormal_palate_morphology1.03914323
61MP0003787_abnormal_imprinting1.03308279
62MP0001286_abnormal_eye_development1.02907359
63MP0002653_abnormal_ependyma_morphology1.02865462
64MP0001919_abnormal_reproductive_system1.01627591
65MP0003567_abnormal_fetal_cardiomyocyte1.01079916
66MP0005394_taste/olfaction_phenotype1.00245565
67MP0005499_abnormal_olfactory_system1.00245565
68MP0001299_abnormal_eye_distance/1.00085501
69MP0004147_increased_porphyrin_level0.99083280
70MP0009703_decreased_birth_body0.98989925
71MP0002735_abnormal_chemical_nociception0.98285307
72MP0009672_abnormal_birth_weight0.97959602
73MP0009250_abnormal_appendicular_skeleto0.97002532
74MP0002736_abnormal_nociception_after0.96581035
75MP0001727_abnormal_embryo_implantation0.94887904
76MP0002751_abnormal_autonomic_nervous0.94632751
77MP0001730_embryonic_growth_arrest0.94056706
78MP0002184_abnormal_innervation0.93600196
79MP0001145_abnormal_male_reproductive0.93196631
80MP0000049_abnormal_middle_ear0.91121366
81MP0002210_abnormal_sex_determination0.90166889
82MP0010386_abnormal_urinary_bladder0.90128843
83MP0000631_abnormal_neuroendocrine_gland0.89930443
84MP0005187_abnormal_penis_morphology0.88304255
85MP0000653_abnormal_sex_gland0.88223919
86MP0005389_reproductive_system_phenotype0.86671410
87MP0003221_abnormal_cardiomyocyte_apopto0.86610128
88MP0000534_abnormal_ureter_morphology0.85470534
89MP0002837_dystrophic_cardiac_calcinosis0.85214985
90MP0000372_irregular_coat_pigmentation0.84833675
91MP0003115_abnormal_respiratory_system0.83852313
92MP0003183_abnormal_peptide_metabolism0.83341101
93MP0003119_abnormal_digestive_system0.81865146
94MP0003935_abnormal_craniofacial_develop0.81264964
95MP0005391_vision/eye_phenotype0.81190733
96MP0001119_abnormal_female_reproductive0.81018856
97MP0002102_abnormal_ear_morphology0.80708204
98MP0000538_abnormal_urinary_bladder0.80263884
99MP0005551_abnormal_eye_electrophysiolog0.79107482
100MP0001929_abnormal_gametogenesis0.78580401

Predicted human phenotypes

RankGene SetZ-score
1Hyperalaninemia (HP:0003348)4.71570494
2Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.71570494
3Abnormality of alanine metabolism (HP:0010916)4.71570494
4Birth length less than 3rd percentile (HP:0003561)4.04434707
5Hypoglycemic seizures (HP:0002173)3.68664906
6Symptomatic seizures (HP:0011145)3.67874830
7Hyperinsulinemic hypoglycemia (HP:0000825)3.43241375
8Constricted visual fields (HP:0001133)3.29242793
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.26851519
10Pancreatic islet-cell hyperplasia (HP:0004510)3.23960325
11Homocystinuria (HP:0002156)3.17600805
12Abnormality of homocysteine metabolism (HP:0010919)3.17600805
13Chromsome breakage (HP:0040012)3.08848926
14Cortical dysplasia (HP:0002539)2.95466772
15Abnormality of the fetal cardiovascular system (HP:0010948)2.80197245
16Abnormal umbilical cord blood vessels (HP:0011403)2.80197245
17Single umbilical artery (HP:0001195)2.80197245
18Long foot (HP:0001833)2.79795842
19Amniotic constriction ring (HP:0009775)2.75790738
20Abnormality of placental membranes (HP:0011409)2.75790738
21Abnormality of serum amino acid levels (HP:0003112)2.73383122
22Hypoglycemic coma (HP:0001325)2.70337699
23Reduced subcutaneous adipose tissue (HP:0003758)2.61077781
24Curly hair (HP:0002212)2.53185933
25Congenital, generalized hypertrichosis (HP:0004540)2.47592138
26Insulin-resistant diabetes mellitus (HP:0000831)2.40483769
27Aplasia/Hypoplasia of the uvula (HP:0010293)2.40037587
28Abnormality of chromosome stability (HP:0003220)2.36365252
29Abnormal lung lobation (HP:0002101)2.33437214
30Abnormality of sulfur amino acid metabolism (HP:0004339)2.31144003
31Pendular nystagmus (HP:0012043)2.30054707
32Meckel diverticulum (HP:0002245)2.29614036
33Long clavicles (HP:0000890)2.29020048
34Abnormality of the labia minora (HP:0012880)2.28332538
35Arteriovenous malformation (HP:0100026)2.26831235
36Patchy hypopigmentation of hair (HP:0011365)2.26480298
37Decreased electroretinogram (ERG) amplitude (HP:0000654)2.18467475
38Acute necrotizing encephalopathy (HP:0006965)2.18334140
39Abnormalities of placenta or umbilical cord (HP:0001194)2.17213570
40Progressive external ophthalmoplegia (HP:0000590)2.16227524
41White forelock (HP:0002211)2.15461335
42Hyperglycemia (HP:0003074)2.15009271
43Abnormality of the ileum (HP:0001549)2.12763291
44Abnormality of endocrine pancreas physiology (HP:0012093)2.10735632
45Abnormality of the pancreatic islet cells (HP:0006476)2.10735632
46Abnormality of the carotid arteries (HP:0005344)2.10240315
47Chronic hepatic failure (HP:0100626)2.09963851
48Horseshoe kidney (HP:0000085)2.09115821
49Acute encephalopathy (HP:0006846)2.08386820
50Abnormality of the umbilical cord (HP:0010881)2.07306901
51Anencephaly (HP:0002323)2.07069519
52Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.06914304
53Type 2 muscle fiber atrophy (HP:0003554)2.06084941
54Enlarged penis (HP:0000040)2.05690634
55Supernumerary spleens (HP:0009799)2.03069026
56Abnormality of methionine metabolism (HP:0010901)2.02625833
57Stenosis of the external auditory canal (HP:0000402)1.97416078
58Ketoacidosis (HP:0001993)1.96468827
59Chorioretinal atrophy (HP:0000533)1.96334310
60Abnormality of the preputium (HP:0100587)1.91136522
61Hepatoblastoma (HP:0002884)1.90812639
62Reticulocytopenia (HP:0001896)1.89822695
63Ectopic kidney (HP:0000086)1.89501495
64Esophageal varix (HP:0002040)1.88341187
65Sloping forehead (HP:0000340)1.87273302
66Colon cancer (HP:0003003)1.85992550
67Tubulointerstitial nephritis (HP:0001970)1.85985828
68Premature ovarian failure (HP:0008209)1.85820002
69Congenital sensorineural hearing impairment (HP:0008527)1.85658598
70Increased hepatocellular lipid droplets (HP:0006565)1.84309877
71Cerebral edema (HP:0002181)1.84131915
72Abnormal mitochondria in muscle tissue (HP:0008316)1.83453120
73Progressive macrocephaly (HP:0004481)1.83449447
74Small hand (HP:0200055)1.82365678
75Duodenal stenosis (HP:0100867)1.81611760
76Small intestinal stenosis (HP:0012848)1.81611760
77Impaired vibration sensation in the lower limbs (HP:0002166)1.79510057
78Methylmalonic acidemia (HP:0002912)1.78889837
79Volvulus (HP:0002580)1.75732918
80Hypoalphalipoproteinemia (HP:0003233)1.74852067
81Postnatal microcephaly (HP:0005484)1.73543984
82Conjunctival telangiectasia (HP:0000524)1.73522469
83Muscle fiber atrophy (HP:0100295)1.72612712
84Rib fusion (HP:0000902)1.71148747
85Pancreatic fibrosis (HP:0100732)1.71066079
86Increased serum lactate (HP:0002151)1.68934733
87Lipid accumulation in hepatocytes (HP:0006561)1.67992469
88Astigmatism (HP:0000483)1.66997737
89Increased CSF lactate (HP:0002490)1.66874512
90Mitochondrial inheritance (HP:0001427)1.65858815
91Rhabdomyosarcoma (HP:0002859)1.65661325
92Abnormality of aspartate family amino acid metabolism (HP:0010899)1.65495677
93Hypoplastic heart (HP:0001961)1.65350586
94Pancreatic cysts (HP:0001737)1.64885101
95Nausea (HP:0002018)1.64378389
96Lactic acidosis (HP:0003128)1.64319371
97Shoulder girdle muscle weakness (HP:0003547)1.63458625
98Maternal diabetes (HP:0009800)1.63023071
99Abnormality of the pons (HP:0007361)1.62875723
100Hyperphosphaturia (HP:0003109)1.60570761

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR5.86337380
2CDC72.99589363
3SRPK12.73082359
4BRSK22.63695221
5PLK42.39368446
6BMPR1B2.37822967
7ACVR1B2.27770323
8PBK2.20921376
9WNK32.09382331
10MKNK22.08697477
11ZAK2.01787182
12CASK1.96074284
13TSSK61.92291751
14BRD41.92137154
15NUAK11.90021337
16CCNB11.80044189
17PLK31.77406581
18TTK1.75831298
19BUB11.69255904
20MKNK11.68869950
21EIF2AK31.61699152
22FRK1.57141944
23ERBB41.53856392
24STK161.51784833
25WEE11.51121357
26TRIM281.39496136
27PLK11.38771253
28MAP2K71.33871917
29PLK21.33348581
30DYRK31.30364840
31MAP3K41.29004526
32CDK91.25717513
33TAF11.23836691
34TNIK1.23537122
35VRK21.22612069
36MST41.14533388
37VRK11.13802778
38DYRK21.08331455
39EIF2AK11.07993988
40PDK21.06124976
41BRSK11.05827218
42EPHB21.04296844
43ATR1.02354622
44PNCK1.01814913
45NEK11.01691338
46ERBB30.93028076
47CHEK20.90197903
48LATS10.89043128
49STK30.88983695
50SGK20.87355304
51SGK2230.86800902
52SGK4940.86800902
53AURKA0.86018613
54NTRK20.85536931
55AURKB0.83962168
56NEK20.81647977
57TIE10.81057170
58BCR0.78469936
59CSNK1G10.76936247
60CSNK1G20.74074022
61MAP4K20.71749075
62CHEK10.69091705
63PAK30.69049830
64TGFBR10.67708750
65STK38L0.67161812
66PIM20.66626927
67FGR0.63014572
68RPS6KB20.60546995
69CSNK1G30.60255826
70ATM0.59704748
71CSNK1A1L0.56499370
72GRK10.55547819
73STK40.53534045
74CLK10.52776896
75ADRBK10.51781246
76EIF2AK20.51655131
77AKT30.48659069
78CDK20.47719244
79MAP2K30.45992618
80MAP3K30.45835162
81CAMK1G0.45657185
82OBSCN0.44517760
83PRKCE0.44427539
84CSNK1E0.43887585
85CSNK1A10.43595942
86CDK10.43398417
87YES10.43150015
88TLK10.42016593
89FLT30.40502697
90CSNK2A10.39284010
91CSNK2A20.38738834
92STK100.37832686
93SGK30.36159123
94RPS6KA40.35992326
95CDK80.35907821
96OXSR10.35708128
97MAP3K50.33743124
98MARK10.32268072
99STK390.30203658
100ABL20.28944615

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.16859441
2One carbon pool by folate_Homo sapiens_hsa006702.84676662
3Proteasome_Homo sapiens_hsa030502.78632076
4RNA polymerase_Homo sapiens_hsa030202.67854701
5Selenocompound metabolism_Homo sapiens_hsa004502.59751822
6Mismatch repair_Homo sapiens_hsa034302.53869717
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.45686239
8DNA replication_Homo sapiens_hsa030302.43369266
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.42949000
10RNA transport_Homo sapiens_hsa030132.40068668
11Spliceosome_Homo sapiens_hsa030402.38786758
12Fanconi anemia pathway_Homo sapiens_hsa034602.34383387
13Homologous recombination_Homo sapiens_hsa034402.23947288
14Protein export_Homo sapiens_hsa030602.23607426
15Oxidative phosphorylation_Homo sapiens_hsa001902.15667829
16Cysteine and methionine metabolism_Homo sapiens_hsa002701.95605487
17Non-homologous end-joining_Homo sapiens_hsa034501.95357273
18Basal transcription factors_Homo sapiens_hsa030221.95119655
19Steroid biosynthesis_Homo sapiens_hsa001001.83142660
20Sulfur metabolism_Homo sapiens_hsa009201.77620445
21Nucleotide excision repair_Homo sapiens_hsa034201.77335058
22RNA degradation_Homo sapiens_hsa030181.73783934
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.72153521
24mRNA surveillance pathway_Homo sapiens_hsa030151.64568471
25Cell cycle_Homo sapiens_hsa041101.61890170
26Parkinsons disease_Homo sapiens_hsa050121.60833807
27Collecting duct acid secretion_Homo sapiens_hsa049661.58575091
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52521674
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.52442430
30Base excision repair_Homo sapiens_hsa034101.49022272
31Huntingtons disease_Homo sapiens_hsa050161.42652521
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.42647651
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.41794436
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.39366539
35Propanoate metabolism_Homo sapiens_hsa006401.38502808
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34070768
37Pyrimidine metabolism_Homo sapiens_hsa002401.28342407
38Fatty acid elongation_Homo sapiens_hsa000621.27080279
39Sulfur relay system_Homo sapiens_hsa041221.24592488
40Ribosome_Homo sapiens_hsa030101.11765733
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.10753043
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08840846
43Alcoholism_Homo sapiens_hsa050341.08773950
44p53 signaling pathway_Homo sapiens_hsa041151.07525887
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06059812
46Alzheimers disease_Homo sapiens_hsa050101.01977614
47Biosynthesis of amino acids_Homo sapiens_hsa012300.98424025
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97327805
49Purine metabolism_Homo sapiens_hsa002300.95328912
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92754490
51Nicotine addiction_Homo sapiens_hsa050330.91335310
52Pyruvate metabolism_Homo sapiens_hsa006200.87456702
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87390378
54Vibrio cholerae infection_Homo sapiens_hsa051100.87247982
55Vitamin B6 metabolism_Homo sapiens_hsa007500.82434450
56Butanoate metabolism_Homo sapiens_hsa006500.80219400
57Adherens junction_Homo sapiens_hsa045200.78053506
58Glutathione metabolism_Homo sapiens_hsa004800.76923581
59Systemic lupus erythematosus_Homo sapiens_hsa053220.74936418
60Arginine biosynthesis_Homo sapiens_hsa002200.73613730
61Thyroid cancer_Homo sapiens_hsa052160.72540442
62Regulation of autophagy_Homo sapiens_hsa041400.72245070
63Hippo signaling pathway_Homo sapiens_hsa043900.70165035
64GABAergic synapse_Homo sapiens_hsa047270.66030036
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63334613
66TGF-beta signaling pathway_Homo sapiens_hsa043500.62453841
67Vitamin digestion and absorption_Homo sapiens_hsa049770.61934353
68Oocyte meiosis_Homo sapiens_hsa041140.59290082
69Cardiac muscle contraction_Homo sapiens_hsa042600.57914769
70Metabolic pathways_Homo sapiens_hsa011000.57593087
71Carbon metabolism_Homo sapiens_hsa012000.55710915
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52376731
73Fatty acid metabolism_Homo sapiens_hsa012120.45060852
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44839854
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.41693688
76Synaptic vesicle cycle_Homo sapiens_hsa047210.40609644
77Circadian rhythm_Homo sapiens_hsa047100.40535535
78Galactose metabolism_Homo sapiens_hsa000520.40133037
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39908064
80N-Glycan biosynthesis_Homo sapiens_hsa005100.39824742
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38719326
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38020897
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37814645
84Serotonergic synapse_Homo sapiens_hsa047260.37257293
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36294818
86Melanoma_Homo sapiens_hsa052180.35369781
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35348738
88Morphine addiction_Homo sapiens_hsa050320.34850167
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33847297
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31857177
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30638997
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30098508
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30066498
94Dopaminergic synapse_Homo sapiens_hsa047280.27516032
95Peroxisome_Homo sapiens_hsa041460.26461028
96Lysine degradation_Homo sapiens_hsa003100.25371822
97Tight junction_Homo sapiens_hsa045300.24394461
98Folate biosynthesis_Homo sapiens_hsa007900.23752009
99Basal cell carcinoma_Homo sapiens_hsa052170.23557478
100Taste transduction_Homo sapiens_hsa047420.22318409

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