ZNF350

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)3.68932023
2tryptophan metabolic process (GO:0006568)3.61935190
3response to pheromone (GO:0019236)3.42662372
4indolalkylamine metabolic process (GO:0006586)3.41358297
5adenosine metabolic process (GO:0046085)3.39462197
6adaptation of signaling pathway (GO:0023058)3.28517849
7neural tube formation (GO:0001841)3.21521728
8DNA deamination (GO:0045006)3.18010218
9positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.16280791
10regulation of memory T cell differentiation (GO:0043380)3.12418627
11activated T cell proliferation (GO:0050798)3.02981860
12negative regulation of T-helper cell differentiation (GO:0045623)3.02867868
13negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.02867868
14histone mRNA catabolic process (GO:0071044)2.99746739
15regulation of germinal center formation (GO:0002634)2.97184900
16natural killer cell activation involved in immune response (GO:0002323)2.94974517
17negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.92218784
18regulation of interferon-alpha production (GO:0032647)2.91846774
19CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.89666970
20T-helper cell differentiation (GO:0042093)2.89666970
21indole-containing compound catabolic process (GO:0042436)2.87190214
22indolalkylamine catabolic process (GO:0046218)2.87190214
23tryptophan catabolic process (GO:0006569)2.87190214
24positive regulation of interferon-alpha production (GO:0032727)2.84880804
25negative regulation of interleukin-12 production (GO:0032695)2.82926660
26I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.82708223
27positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.80909027
28histamine secretion (GO:0001821)2.79717329
29fucose catabolic process (GO:0019317)2.79478517
30L-fucose metabolic process (GO:0042354)2.79478517
31L-fucose catabolic process (GO:0042355)2.79478517
32positive regulation of alpha-beta T cell proliferation (GO:0046641)2.78219406
33immunoglobulin mediated immune response (GO:0016064)2.77748556
34regulation of alpha-beta T cell proliferation (GO:0046640)2.76657701
35positive regulation of protein homodimerization activity (GO:0090073)2.75742939
36cellular response to ethanol (GO:0071361)2.75150723
37positive regulation of defense response to virus by host (GO:0002230)2.74545094
38regulation of T-helper 1 cell differentiation (GO:0045625)2.74024146
39positive regulation of interferon-beta production (GO:0032728)2.71839388
40regulation of interferon-beta biosynthetic process (GO:0045357)2.70179997
41B cell mediated immunity (GO:0019724)2.70159601
42kynurenine metabolic process (GO:0070189)2.70103845
43negative regulation of cAMP-mediated signaling (GO:0043951)2.67877703
44microglial cell activation (GO:0001774)2.66487252
45positive regulation of interleukin-1 beta secretion (GO:0050718)2.66017955
46interferon-gamma production (GO:0032609)2.65135560
47L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.63917127
48alpha-beta T cell differentiation involved in immune response (GO:0002293)2.63857679
49alpha-beta T cell activation involved in immune response (GO:0002287)2.63857679
50T cell differentiation involved in immune response (GO:0002292)2.63857679
51regulation of B cell receptor signaling pathway (GO:0050855)2.63122467
52positive regulation of steroid hormone secretion (GO:2000833)2.62817247
53regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.61073206
54regulation of B cell apoptotic process (GO:0002902)2.60751419
55positive regulation of interleukin-12 production (GO:0032735)2.60555732
56regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.58090058
57regulation of T cell receptor signaling pathway (GO:0050856)2.57406542
58positive regulation of T-helper 1 type immune response (GO:0002827)2.56872451
59regulation of T-helper 1 type immune response (GO:0002825)2.56173854
60regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.55705593
61regulation of interleukin-1 beta secretion (GO:0050706)2.50577868
62nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.48078355
63CD4-positive, alpha-beta T cell activation (GO:0035710)2.47971798
64CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.47595344
65negative regulation of alpha-beta T cell differentiation (GO:0046639)2.45072809
66negative regulation of thymocyte apoptotic process (GO:0070244)2.44304880
67positive regulation of interleukin-1 secretion (GO:0050716)2.43915954
68platelet dense granule organization (GO:0060155)2.43630881
69regulation of thymocyte apoptotic process (GO:0070243)2.42462049
70regulation of interferon-beta production (GO:0032648)2.42392645
71regulation of regulatory T cell differentiation (GO:0045589)2.41913142
72cellular response to exogenous dsRNA (GO:0071360)2.41738289
73regulation of interleukin-12 production (GO:0032655)2.40647377
74positive regulation of interleukin-2 production (GO:0032743)2.40460902
75nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (GO:0035872)2.40245723
76epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.39824595
77positive regulation of toll-like receptor signaling pathway (GO:0034123)2.39021377
78positive regulation by symbiont of host defense response (GO:0052509)2.38947558
79modulation by symbiont of host defense response (GO:0052031)2.38947558
80modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.38947558
81modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.38947558
82positive regulation by organism of defense response of other organism involved in symbiotic interact2.38947558
83modulation by symbiont of host immune response (GO:0052553)2.38947558
84positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.38724314
85negative regulation by host of viral transcription (GO:0043922)2.38287766
86negative regulation of interleukin-1 beta production (GO:0032691)2.37820603
87positive regulation of T cell mediated cytotoxicity (GO:0001916)2.37327788
88positive regulation of gamma-delta T cell activation (GO:0046645)2.34633508
89positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.34243270
90negative regulation of alpha-beta T cell activation (GO:0046636)2.34066879
91negative regulation of protein oligomerization (GO:0032460)2.33213583
92myeloid leukocyte mediated immunity (GO:0002444)2.33101642
93interferon-gamma secretion (GO:0072643)2.32768599
94DNA methylation involved in gamete generation (GO:0043046)2.32133799
95purinergic nucleotide receptor signaling pathway (GO:0035590)2.31911525
96positive regulation of granulocyte differentiation (GO:0030854)2.31905009
97positive T cell selection (GO:0043368)2.30979454
98alpha-beta T cell activation (GO:0046631)2.30977270
99alpha-beta T cell differentiation (GO:0046632)2.30364702
100cellular response to interleukin-15 (GO:0071350)2.30012814

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.48423090
2ZNF274_21170338_ChIP-Seq_K562_Hela3.24403319
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.05079286
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.03045315
5VDR_22108803_ChIP-Seq_LS180_Human2.58667246
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.49662386
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.47077619
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.46496597
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.32918050
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.29971103
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.23722944
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.23204743
13* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.21063670
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.19076071
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.18298534
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.11394956
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.09789319
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.07536104
19ER_23166858_ChIP-Seq_MCF-7_Human1.96502199
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.95489286
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.95125953
22* VDR_23849224_ChIP-Seq_CD4+_Human1.84779272
23* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.78092052
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.75036113
25IGF1R_20145208_ChIP-Seq_DFB_Human1.73682387
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.73597542
27EWS_26573619_Chip-Seq_HEK293_Human1.73490575
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66933896
29GATA3_26560356_Chip-Seq_TH2_Human1.64403750
30ELK1_19687146_ChIP-ChIP_HELA_Human1.60882140
31P300_19829295_ChIP-Seq_ESCs_Human1.57074940
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56425265
33IRF1_19129219_ChIP-ChIP_H3396_Human1.56335537
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51695210
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50901406
36MYB_26560356_Chip-Seq_TH2_Human1.49557526
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47286060
38STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.45295367
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.43185881
40IRF8_27001747_Chip-Seq_BMDM_Mouse1.41436674
41NFE2_27457419_Chip-Seq_LIVER_Mouse1.40756421
42IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39537301
43CBP_20019798_ChIP-Seq_JUKART_Human1.39537301
44EZH2_27294783_Chip-Seq_NPCs_Mouse1.38693962
45FOXP3_21729870_ChIP-Seq_TREG_Human1.38567346
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37823434
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35797277
48TP53_22573176_ChIP-Seq_HFKS_Human1.34540095
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.31772894
50* GBX2_23144817_ChIP-Seq_PC3_Human1.31073815
51GATA3_27048872_Chip-Seq_THYMUS_Human1.27365541
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25909107
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24732080
54PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24540000
55AR_20517297_ChIP-Seq_VCAP_Human1.24172487
56FUS_26573619_Chip-Seq_HEK293_Human1.24043921
57RUNX_20019798_ChIP-Seq_JUKART_Human1.23861807
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22911427
59POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22911427
60SMAD_19615063_ChIP-ChIP_OVARY_Human1.22780911
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21441345
62CRX_20693478_ChIP-Seq_RETINA_Mouse1.20560807
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19767382
64NANOG_19829295_ChIP-Seq_ESCs_Human1.18257917
65SOX2_19829295_ChIP-Seq_ESCs_Human1.18257917
66TAF15_26573619_Chip-Seq_HEK293_Human1.17790933
67SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.17115376
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16690271
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16642838
70CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16216696
71EGR1_23403033_ChIP-Seq_LIVER_Mouse1.12585284
72PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11842469
73PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11047437
74MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.10941960
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10940779
76LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10692037
77SMRT_27268052_Chip-Seq_Bcells_Human1.10493750
78EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10428795
79SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.09307813
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08737913
81* SPI1_23547873_ChIP-Seq_NB4_Human1.08313279
82BCAT_22108803_ChIP-Seq_LS180_Human1.07932955
83PRDM14_20953172_ChIP-Seq_ESCs_Human1.07358214
84CDX2_22108803_ChIP-Seq_LS180_Human1.04767110
85SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03734137
86FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03241257
87FOXA1_25329375_ChIP-Seq_VCAP_Human1.03241257
88NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02604233
89FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02338681
90RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00814358
91VDR_24787735_ChIP-Seq_THP-1_Human0.99789146
92FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.99130387
93SALL4_22934838_ChIP-ChIP_CD34+_Human0.99100752
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98902549
95AR_25329375_ChIP-Seq_VCAP_Human0.98357260
96FLI1_21867929_ChIP-Seq_TH2_Mouse0.98259973
97HTT_18923047_ChIP-ChIP_STHdh_Human0.97719055
98SCL_19346495_ChIP-Seq_HPC-7_Human0.96685236
99TCF4_23295773_ChIP-Seq_U87_Human0.96540449
100STAT3_23295773_ChIP-Seq_U87_Human0.96504109

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.16479434
2MP0001835_abnormal_antigen_presentation3.04982508
3MP0008877_abnormal_DNA_methylation2.91341044
4MP0003195_calcinosis2.91054929
5MP0000372_irregular_coat_pigmentation2.79251575
6MP0005671_abnormal_response_to2.76827777
7MP0002166_altered_tumor_susceptibility2.67666614
8MP0002148_abnormal_hypersensitivity_rea2.60117115
9MP0005075_abnormal_melanosome_morpholog2.39345547
10MP0002006_tumorigenesis2.39014762
11MP0000569_abnormal_digit_pigmentation2.24390043
12MP0009785_altered_susceptibility_to2.21407209
13MP0001800_abnormal_humoral_immune2.10829217
14MP0005310_abnormal_salivary_gland2.08763057
15MP0005000_abnormal_immune_tolerance2.07661541
16MP0002102_abnormal_ear_morphology2.03810584
17MP0008057_abnormal_DNA_replication2.00766691
18MP0002452_abnormal_antigen_presenting1.92148726
19MP0002723_abnormal_immune_serum1.91236874
20MP0005387_immune_system_phenotype1.76441567
21MP0001790_abnormal_immune_system1.76441567
22MP0009764_decreased_sensitivity_to1.70879505
23MP0002420_abnormal_adaptive_immunity1.68305942
24MP0001819_abnormal_immune_cell1.67495733
25MP0005174_abnormal_tail_pigmentation1.65353611
26MP0006082_CNS_inflammation1.64257515
27MP0005025_abnormal_response_to1.61238892
28MP0002419_abnormal_innate_immunity1.60961646
29MP0003436_decreased_susceptibility_to1.56355815
30MP0003252_abnormal_bile_duct1.50431070
31MP0000015_abnormal_ear_pigmentation1.50428481
32MP0004381_abnormal_hair_follicle1.49607821
33MP0003303_peritoneal_inflammation1.44117957
34MP0002138_abnormal_hepatobiliary_system1.43178182
35MP0005167_abnormal_blood-brain_barrier1.41948331
36MP0000685_abnormal_immune_system1.40677310
37MP0003763_abnormal_thymus_physiology1.40007518
38MP0002277_abnormal_respiratory_mucosa1.38896204
39MP0002009_preneoplasia1.38321006
40MP0001845_abnormal_inflammatory_respons1.36929004
41MP0002405_respiratory_system_inflammati1.36084001
42MP0008872_abnormal_physiological_respon1.35883670
43MP0001545_abnormal_hematopoietic_system1.34049061
44MP0005397_hematopoietic_system_phenotyp1.34049061
45MP0009697_abnormal_copulation1.32169791
46MP0000689_abnormal_spleen_morphology1.29457242
47MP0004043_abnormal_pH_regulation1.26328286
48MP0001501_abnormal_sleep_pattern1.24996764
49MP0000716_abnormal_immune_system1.24288366
50MP0005084_abnormal_gallbladder_morpholo1.24248440
51MP0009278_abnormal_bone_marrow1.23603667
52MP0003787_abnormal_imprinting1.20493839
53MP0005551_abnormal_eye_electrophysiolog1.20076772
54MP0002398_abnormal_bone_marrow1.20061097
55MP0002837_dystrophic_cardiac_calcinosis1.15369451
56MP0010678_abnormal_skin_adnexa1.11470803
57MP0001919_abnormal_reproductive_system1.11358331
58MP0000371_diluted_coat_color1.09567739
59MP0001853_heart_inflammation1.07106627
60MP0000383_abnormal_hair_follicle1.05983852
61MP0006036_abnormal_mitochondrial_physio1.02528887
62MP0002234_abnormal_pharynx_morphology1.00430860
63MP0008058_abnormal_DNA_repair0.99283048
64MP0002876_abnormal_thyroid_physiology0.97064401
65MP0003718_maternal_effect0.96812057
66MP0001533_abnormal_skeleton_physiology0.95780773
67MP0008469_abnormal_protein_level0.95711191
68MP0000427_abnormal_hair_cycle0.95445057
69MP0001986_abnormal_taste_sensitivity0.94367976
70MP0002722_abnormal_immune_system0.93370561
71MP0002429_abnormal_blood_cell0.91461563
72MP0001968_abnormal_touch/_nociception0.91065754
73MP0002693_abnormal_pancreas_physiology0.88523887
74MP0006035_abnormal_mitochondrial_morpho0.87794467
75MP0010155_abnormal_intestine_physiology0.87492304
76MP0004883_abnormal_blood_vessel0.86261230
77MP0003646_muscle_fatigue0.85580095
78MP0002095_abnormal_skin_pigmentation0.85087714
79MP0008775_abnormal_heart_ventricle0.84136004
80MP0005646_abnormal_pituitary_gland0.83394345
81MP0000516_abnormal_urinary_system0.83229440
82MP0005367_renal/urinary_system_phenotyp0.83229440
83MP0005645_abnormal_hypothalamus_physiol0.83222065
84MP0005253_abnormal_eye_physiology0.82744808
85MP0002254_reproductive_system_inflammat0.82295039
86MP0005464_abnormal_platelet_physiology0.81043208
87MP0000230_abnormal_systemic_arterial0.80786689
88MP0004742_abnormal_vestibular_system0.79894279
89MP0003866_abnormal_defecation0.79290342
90MP0005647_abnormal_sex_gland0.78744584
91MP0000703_abnormal_thymus_morphology0.78179162
92MP0001756_abnormal_urination0.76985166
93MP0008873_increased_physiological_sensi0.76725230
94MP0003045_fibrosis0.75426764
95MP0004484_altered_response_of0.74937458
96MP0005636_abnormal_mineral_homeostasis0.73658081
97MP0010234_abnormal_vibrissa_follicle0.73549239
98MP0001764_abnormal_homeostasis0.72933530
99MP0010386_abnormal_urinary_bladder0.72722822
100MP0008995_early_reproductive_senescence0.72712292

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)4.08288830
2Congenital stationary night blindness (HP:0007642)3.55873836
3Pancreatic cysts (HP:0001737)3.49577990
4Stomach cancer (HP:0012126)3.26390952
5Hypothermia (HP:0002045)3.12638626
6Thyroiditis (HP:0100646)3.11218653
7Abnormality of the renal cortex (HP:0011035)2.96771126
8Methylmalonic acidemia (HP:0002912)2.95745306
9Optic neuritis (HP:0100653)2.94257474
10Retrobulbar optic neuritis (HP:0100654)2.94257474
11Elevated erythrocyte sedimentation rate (HP:0003565)2.92323568
12Pancreatic fibrosis (HP:0100732)2.82537973
13Progressive inability to walk (HP:0002505)2.75246487
14Azoospermia (HP:0000027)2.64395097
15Prostate neoplasm (HP:0100787)2.59446354
16Abnormal spermatogenesis (HP:0008669)2.58454334
17Severe combined immunodeficiency (HP:0004430)2.53894684
18Abnormality of the prostate (HP:0008775)2.53807498
19Abnormal rod and cone electroretinograms (HP:0008323)2.46070808
20Orchitis (HP:0100796)2.44697598
21Abnormality of B cell number (HP:0010975)2.41891326
22Abnormality of the renal medulla (HP:0100957)2.40630241
23Methylmalonic aciduria (HP:0012120)2.39053335
24Myositis (HP:0100614)2.37316462
25Abnormality of eosinophils (HP:0001879)2.36706872
26Chronic hepatic failure (HP:0100626)2.34667811
27Attenuation of retinal blood vessels (HP:0007843)2.32667090
28Hypoproteinemia (HP:0003075)2.31959872
29Recurrent bacterial skin infections (HP:0005406)2.30871725
30Autoimmune thrombocytopenia (HP:0001973)2.30483582
31Abnormality of T cell number (HP:0011839)2.29198167
32Abolished electroretinogram (ERG) (HP:0000550)2.28634545
33Absent rod-and cone-mediated responses on ERG (HP:0007688)2.27181149
34Tubular atrophy (HP:0000092)2.26656811
35Eosinophilia (HP:0001880)2.26058627
36Gaze-evoked nystagmus (HP:0000640)2.24868471
37Molar tooth sign on MRI (HP:0002419)2.24017063
38Abnormality of midbrain morphology (HP:0002418)2.24017063
39True hermaphroditism (HP:0010459)2.22552251
40Panhypogammaglobulinemia (HP:0003139)2.22136278
41Nephronophthisis (HP:0000090)2.20989244
42Tubulointerstitial nephritis (HP:0001970)2.20017852
43Fair hair (HP:0002286)2.19451839
44T lymphocytopenia (HP:0005403)2.18739995
45Abnormal delayed hypersensitivity skin test (HP:0002963)2.14342117
46Albinism (HP:0001022)2.11064870
47Renal cortical cysts (HP:0000803)2.08794808
48Hyperventilation (HP:0002883)2.08476162
49Bile duct proliferation (HP:0001408)2.06333756
50Abnormal biliary tract physiology (HP:0012439)2.06333756
51Recurrent abscess formation (HP:0002722)2.05972081
52Abnormal drinking behavior (HP:0030082)2.04837869
53Polydipsia (HP:0001959)2.04837869
54Decreased central vision (HP:0007663)2.04551727
55Abnormality of vitamin B metabolism (HP:0004340)2.04169012
56Recurrent fungal infections (HP:0002841)2.03630015
57Neoplasm of the tracheobronchial system (HP:0100552)2.03076872
58Ketoacidosis (HP:0001993)2.00972329
59Abnormality of the vitamin B12 metabolism (HP:0004341)2.00217123
60Encephalitis (HP:0002383)1.99845004
61B lymphocytopenia (HP:0010976)1.99159581
62Leukocytosis (HP:0001974)1.98988200
63Autoimmune hemolytic anemia (HP:0001890)1.98511408
64Alveolar cell carcinoma (HP:0006519)1.97444828
65Chronic diarrhea (HP:0002028)1.96497836
66IgG deficiency (HP:0004315)1.94421319
67Generalized hypopigmentation of hair (HP:0011358)1.94349136
68Combined immunodeficiency (HP:0005387)1.93767820
69Decreased electroretinogram (ERG) amplitude (HP:0000654)1.92373155
70Chronic otitis media (HP:0000389)1.92149102
71Progressive macrocephaly (HP:0004481)1.91212272
72Inability to walk (HP:0002540)1.89055651
73Pendular nystagmus (HP:0012043)1.88717551
74Constricted visual fields (HP:0001133)1.88532958
75Keratoconjunctivitis (HP:0001096)1.88516565
76Abnormality of lateral ventricle (HP:0030047)1.87016318
77Increased CSF lactate (HP:0002490)1.87001234
78Progressive microcephaly (HP:0000253)1.86046648
79Absent speech (HP:0001344)1.84936834
80Tubulointerstitial abnormality (HP:0001969)1.83702461
81Keratoconjunctivitis sicca (HP:0001097)1.82252668
82Widely spaced teeth (HP:0000687)1.82070017
83Abnormality of T cells (HP:0002843)1.81712073
843-Methylglutaconic aciduria (HP:0003535)1.81463533
85Ketosis (HP:0001946)1.78025189
86Pulmonary infiltrates (HP:0002113)1.76751189
87Anorexia (HP:0002039)1.75313779
88Cystic liver disease (HP:0006706)1.74791519
89Acute necrotizing encephalopathy (HP:0006965)1.74147668
90Abnormality of the pons (HP:0007361)1.73876967
91Mitochondrial inheritance (HP:0001427)1.73811215
92Hemoptysis (HP:0002105)1.73570958
93Polyuria (HP:0000103)1.73157173
94Abnormality of secondary sexual hair (HP:0009888)1.71472525
95Abnormality of the axillary hair (HP:0100134)1.71472525
96Amelogenesis imperfecta (HP:0000705)1.71312735
97Vasculitis (HP:0002633)1.70736833
98Facial diplegia (HP:0001349)1.70523094
99Increased neuronal autofluorescent lipopigment (HP:0002074)1.67476312
100Aplasia/Hypoplasia of the tibia (HP:0005772)1.66036153

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.60251791
2TAOK34.56976196
3NUAK13.52495692
4MAP4K23.10650140
5EIF2AK32.98960096
6STK162.68766172
7MST42.65468556
8TXK2.47532370
9MAP3K142.09800325
10TNK22.02467166
11CAMK1D1.99744963
12EIF2AK11.93899779
13ADRBK21.90941358
14IKBKE1.81914789
15ACVR1B1.78470652
16IKBKB1.74103064
17BMPR1B1.65612547
18ZAK1.41865454
19TEC1.40335610
20IRAK11.39780108
21MAPKAPK31.39745509
22TRIM281.39553784
23WNK31.37479600
24MAPK131.32562382
25CAMK1G1.29774870
26AKT31.27719001
27BMPR21.22602219
28CHUK1.14057116
29TRPM71.13007424
30INSRR1.12245516
31IRAK41.04734342
32GRK71.03188341
33OXSR11.01888236
34CAMKK21.01843754
35PIK3CG0.96615022
36RIPK40.94308899
37GRK10.94013512
38MAP4K10.91772458
39PINK10.90633727
40ITK0.89664918
41KIT0.83358645
42PAK30.80768502
43NLK0.78979355
44EIF2AK20.78518656
45STK30.78280851
46ERBB30.76662365
47MKNK20.76595131
48FER0.76497375
49SYK0.75257204
50MARK30.74477913
51BRSK20.74082704
52FES0.74010556
53TLK10.72188016
54TYK20.71694381
55PRKCQ0.70990693
56TBK10.70337902
57BCKDK0.68856404
58TGFBR20.68130964
59EPHA30.67607239
60LYN0.66924409
61BLK0.66780486
62LCK0.66625689
63SIK30.66103446
64CSNK1G10.66008883
65BTK0.64954198
66STK390.64018076
67PLK30.61308914
68JAK10.60356392
69PRKAA20.60140497
70FGFR20.59825939
71GRK60.56372963
72DAPK20.55997023
73STK100.55131397
74PIK3CA0.51640312
75BUB10.50546673
76SGK20.48571544
77VRK10.47835640
78TAOK10.45329666
79HCK0.44485883
80CSNK1G30.43910944
81PRKCE0.43515810
82CSNK1G20.43449743
83ADRBK10.42943824
84MAP3K130.42471414
85MATK0.41652962
86YES10.40096590
87CSNK1A1L0.39678971
88PTK2B0.38439944
89STK38L0.38048431
90ABL10.37435115
91CSK0.36367864
92IRAK20.35800508
93CASK0.35764275
94TNIK0.33114429
95JAK30.32833240
96LATS10.32656721
97RPS6KA50.30208171
98MAP3K120.29756636
99CAMK10.29671741
100MAP3K40.29587193

Predicted pathways (KEGG)

RankGene SetZ-score
1Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.65028829
2Allograft rejection_Homo sapiens_hsa053302.62352183
3Graft-versus-host disease_Homo sapiens_hsa053322.59539797
4Type I diabetes mellitus_Homo sapiens_hsa049402.45657069
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.36866962
6Asthma_Homo sapiens_hsa053102.32419106
7Autoimmune thyroid disease_Homo sapiens_hsa053202.31415658
8Primary immunodeficiency_Homo sapiens_hsa053402.21489567
9NOD-like receptor signaling pathway_Homo sapiens_hsa046212.19086384
10Protein export_Homo sapiens_hsa030602.12788005
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.06695598
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.87859643
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.85875381
14Rheumatoid arthritis_Homo sapiens_hsa053231.77553781
15Caffeine metabolism_Homo sapiens_hsa002321.75854959
16Proteasome_Homo sapiens_hsa030501.72065466
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.66719814
18Propanoate metabolism_Homo sapiens_hsa006401.61620796
19Legionellosis_Homo sapiens_hsa051341.60303982
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60155992
21Staphylococcus aureus infection_Homo sapiens_hsa051501.59894057
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.57181726
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.54503787
24RNA polymerase_Homo sapiens_hsa030201.50532329
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.46801883
26Linoleic acid metabolism_Homo sapiens_hsa005911.43336368
27Measles_Homo sapiens_hsa051621.39791569
28Leishmaniasis_Homo sapiens_hsa051401.38145219
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.38089060
30Phototransduction_Homo sapiens_hsa047441.37914325
31Herpes simplex infection_Homo sapiens_hsa051681.32689468
32Antigen processing and presentation_Homo sapiens_hsa046121.32352760
33Basal transcription factors_Homo sapiens_hsa030221.27304915
34Nitrogen metabolism_Homo sapiens_hsa009101.26844332
35Osteoclast differentiation_Homo sapiens_hsa043801.26263970
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.23782663
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.20925571
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.18964739
39Hematopoietic cell lineage_Homo sapiens_hsa046401.18943787
40Fanconi anemia pathway_Homo sapiens_hsa034601.18922347
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.16598620
42Tryptophan metabolism_Homo sapiens_hsa003801.15014632
43Regulation of autophagy_Homo sapiens_hsa041401.14488211
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13184116
45T cell receptor signaling pathway_Homo sapiens_hsa046601.12275014
46Tuberculosis_Homo sapiens_hsa051521.09784026
47RNA degradation_Homo sapiens_hsa030181.06967097
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.06085034
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05439941
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.01636267
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01408298
52Collecting duct acid secretion_Homo sapiens_hsa049660.97945537
53TNF signaling pathway_Homo sapiens_hsa046680.96567449
54Oxidative phosphorylation_Homo sapiens_hsa001900.96199794
55Non-homologous end-joining_Homo sapiens_hsa034500.89408695
56Ether lipid metabolism_Homo sapiens_hsa005650.89367573
57Influenza A_Homo sapiens_hsa051640.88848657
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88141221
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85943119
60Butanoate metabolism_Homo sapiens_hsa006500.85804384
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.85436870
62Mineral absorption_Homo sapiens_hsa049780.83883918
63Dorso-ventral axis formation_Homo sapiens_hsa043200.81206021
64Sulfur metabolism_Homo sapiens_hsa009200.80781775
65Homologous recombination_Homo sapiens_hsa034400.78708874
66Selenocompound metabolism_Homo sapiens_hsa004500.78566023
67Arachidonic acid metabolism_Homo sapiens_hsa005900.76315937
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73327757
69Circadian rhythm_Homo sapiens_hsa047100.73157502
70Chemokine signaling pathway_Homo sapiens_hsa040620.70440910
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70406533
72B cell receptor signaling pathway_Homo sapiens_hsa046620.68185314
73Peroxisome_Homo sapiens_hsa041460.65196053
74Malaria_Homo sapiens_hsa051440.63026882
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60323981
76Sphingolipid metabolism_Homo sapiens_hsa006000.57048284
77Parkinsons disease_Homo sapiens_hsa050120.56967852
78Toxoplasmosis_Homo sapiens_hsa051450.56764482
79African trypanosomiasis_Homo sapiens_hsa051430.56711679
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56205503
81Epstein-Barr virus infection_Homo sapiens_hsa051690.52559932
82ABC transporters_Homo sapiens_hsa020100.50205797
83Ovarian steroidogenesis_Homo sapiens_hsa049130.49908869
84Viral myocarditis_Homo sapiens_hsa054160.49309454
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.44300839
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43625192
87Platelet activation_Homo sapiens_hsa046110.38328782
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35515601
89FoxO signaling pathway_Homo sapiens_hsa040680.35399141
90Hepatitis B_Homo sapiens_hsa051610.35006732
91Serotonergic synapse_Homo sapiens_hsa047260.34695543
92Lysosome_Homo sapiens_hsa041420.34481908
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.34412995
94Fatty acid biosynthesis_Homo sapiens_hsa000610.34027084
95Taste transduction_Homo sapiens_hsa047420.33173810
96Phagosome_Homo sapiens_hsa041450.33118096
97Purine metabolism_Homo sapiens_hsa002300.33091234
98Chemical carcinogenesis_Homo sapiens_hsa052040.31791329
99Vitamin digestion and absorption_Homo sapiens_hsa049770.31095672
100Systemic lupus erythematosus_Homo sapiens_hsa053220.30977748

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