ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	5.17632324
2	regulation of cofactor metabolic process (GO:0051193)	4.98935910
3	regulation of coenzyme metabolic process (GO:0051196)	4.98935910
4	auditory receptor cell differentiation (GO:0042491)	4.86897659
5	regulation of acyl-CoA biosynthetic process (GO:0050812)	4.86872833
6	gamma-aminobutyric acid transport (GO:0015812)	4.41784282
7	protein-cofactor linkage (GO:0018065)	4.35567066
8	negative regulation of oligodendrocyte differentiation (GO:0048715)	4.22917632
9	platelet dense granule organization (GO:0060155)	4.19875785
10	pyrimidine nucleobase catabolic process (GO:0006208)	4.03827824
11	fatty acid elongation (GO:0030497)	4.03725287
12	neural tube formation (GO:0001841)	4.00949725
13	regulation of sulfur metabolic process (GO:0042762)	3.95304018
14	proteasome assembly (GO:0043248)	3.83095190
15	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.73081498
16	positive regulation of vesicle fusion (GO:0031340)	3.66839960
17	presynaptic membrane assembly (GO:0097105)	3.62929113
18	positive regulation of action potential (GO:0045760)	3.58708717
19	positive regulation of mitochondrial fission (GO:0090141)	3.55925542
20	nucleobase catabolic process (GO:0046113)	3.46941681
21	nonmotile primary cilium assembly (GO:0035058)	3.44965157
22	regulation of cilium movement (GO:0003352)	3.34039964
23	cornea development in camera-type eye (GO:0061303)	3.32653194
24	cullin deneddylation (GO:0010388)	3.28474597
25	presynaptic membrane organization (GO:0097090)	3.26768418
26	protein deneddylation (GO:0000338)	3.25423834
27	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	3.17849774
28	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	3.17849774
29	regulation of oligodendrocyte differentiation (GO:0048713)	3.06137912
30	cellular ketone body metabolic process (GO:0046950)	3.04526802
31	neuron cell-cell adhesion (GO:0007158)	3.03523694
32	negative regulation of calcium ion transport into cytosol (GO:0010523)	3.03423617
33	epithelial cilium movement (GO:0003351)	3.03278392
34	membrane assembly (GO:0071709)	2.98366782
35	ribonucleoprotein complex disassembly (GO:0032988)	2.98347294
36	membrane budding (GO:0006900)	2.96810819
37	cell wall macromolecule catabolic process (GO:0016998)	2.95174521
38	cilium or flagellum-dependent cell motility (GO:0001539)	2.93021431
39	negative regulation of mast cell activation (GO:0033004)	2.91178162
40	glycosphingolipid biosynthetic process (GO:0006688)	2.89805956
41	hair cell differentiation (GO:0035315)	2.89567998
42	regulation of neurotransmitter uptake (GO:0051580)	2.89303441
43	artery smooth muscle contraction (GO:0014824)	2.88748016
44	inner ear receptor cell differentiation (GO:0060113)	2.84732962
45	cilium assembly (GO:0042384)	2.82155704
46	cilium morphogenesis (GO:0060271)	2.79213678
47	lipid particle organization (GO:0034389)	2.77413558
48	cilium organization (GO:0044782)	2.77176222
49	behavioral response to cocaine (GO:0048148)	2.76330063
50	lipopolysaccharide biosynthetic process (GO:0009103)	2.72224004
51	negative regulation of membrane potential (GO:0045837)	2.70031627
52	protein neddylation (GO:0045116)	2.68582890
53	signal peptide processing (GO:0006465)	2.67955788
54	protein heterotetramerization (GO:0051290)	2.66176199
55	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	2.65937481
56	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	2.65937481
57	ketone body metabolic process (GO:1902224)	2.65443726
58	cell wall macromolecule metabolic process (GO:0044036)	2.62060467
59	branched-chain amino acid catabolic process (GO:0009083)	2.61960651
60	tonic smooth muscle contraction (GO:0014820)	2.61398272
61	DNA damage response, detection of DNA damage (GO:0042769)	2.61215327
62	prepulse inhibition (GO:0060134)	2.60734588
63	response to pheromone (GO:0019236)	2.58933127
64	adaptation of signaling pathway (GO:0023058)	2.56512416
65	axonal fasciculation (GO:0007413)	2.56083466
66	response to histamine (GO:0034776)	2.55302205
67	negative regulation of axon guidance (GO:1902668)	2.54334871
68	negative regulation of sodium ion transport (GO:0010766)	2.53722181
69	mechanoreceptor differentiation (GO:0042490)	2.50999268
70	tyrosine phosphorylation of STAT protein (GO:0007260)	2.50229367
71	sequestering of actin monomers (GO:0042989)	2.49244479
72	regulation of microtubule-based movement (GO:0060632)	2.49036563
73	regulation of action potential (GO:0098900)	2.48470195
74	establishment of integrated proviral latency (GO:0075713)	2.46870026
75	establishment of viral latency (GO:0019043)	2.45849513
76	reflex (GO:0060004)	2.45728069
77	protein localization to synapse (GO:0035418)	2.42816010
78	nucleobase biosynthetic process (GO:0046112)	2.39797197
79	mitochondrial respiratory chain complex assembly (GO:0033108)	2.39219009
80	serotonin metabolic process (GO:0042428)	2.38525454
81	long-chain fatty acid biosynthetic process (GO:0042759)	2.38072591
82	regulation of mitochondrial fission (GO:0090140)	2.37360956
83	positive regulation of cell cycle G1/S phase transition (GO:1902808)	2.37255083
84	respiratory chain complex IV assembly (GO:0008535)	2.37201714
85	cilium movement (GO:0003341)	2.35712180
86	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.35683818
87	NADH dehydrogenase complex assembly (GO:0010257)	2.35683818
88	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.35683818
89	anterograde synaptic vesicle transport (GO:0048490)	2.35358429
90	cellular response to leptin stimulus (GO:0044320)	2.32871580
91	purine nucleobase biosynthetic process (GO:0009113)	2.31200668
92	positive regulation of amino acid transport (GO:0051957)	2.30497270
93	C4-dicarboxylate transport (GO:0015740)	2.30386319
94	photoreceptor cell maintenance (GO:0045494)	2.30342705
95	mitochondrion morphogenesis (GO:0070584)	2.30067237
96	ganglion development (GO:0061548)	2.28387704
97	head development (GO:0060322)	2.28019868
98	adenosine metabolic process (GO:0046085)	2.27558503
99	organelle disassembly (GO:1903008)	2.27271131
100	intraciliary transport (GO:0042073)	2.27131421

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.64616702
2	IGF1R_20145208_ChIP-Seq_DFB_Human	4.45266872
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.63664312
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.00317519
5	TAF15_26573619_Chip-Seq_HEK293_Human	2.98380503
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.83274450
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.71919881
8	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.67187831
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.57115397
10	EZH2_22144423_ChIP-Seq_EOC_Human	2.47446082
11	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.40521106
12	VDR_22108803_ChIP-Seq_LS180_Human	2.38524147
13	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.31297325
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.22303008
15	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.20048273
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.18286491
17	FUS_26573619_Chip-Seq_HEK293_Human	2.14353246
18	EWS_26573619_Chip-Seq_HEK293_Human	2.11984509
19	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.08859457
20	P300_19829295_ChIP-Seq_ESCs_Human	2.08558798
21	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.05676675
22	ELK1_19687146_ChIP-ChIP_HELA_Human	1.95704326
23	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.83287516
24	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.80830207
25	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.80410538
26	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.79616846
27	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.72172616
28	CBP_20019798_ChIP-Seq_JUKART_Human	1.68061682
29	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.68061682
30	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.65615560
31	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.63667881
32	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.56767464
33	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.56268644
34	SMAD4_21799915_ChIP-Seq_A2780_Human	1.55396131
35	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.54420514
36	ER_23166858_ChIP-Seq_MCF-7_Human	1.51152288
37	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.49092877
38	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.48835021
39	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.47349357
40	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.43771597
41	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.43670485
42	STAT3_23295773_ChIP-Seq_U87_Human	1.41858129
43	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.41251314
44	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.36332276
45	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.36180279
46	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.34802111
47	AR_25329375_ChIP-Seq_VCAP_Human	1.34286190
48	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.33240994
49	AR_21572438_ChIP-Seq_LNCaP_Human	1.31201620
50	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.31089388
51	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.30069886
52	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.28131585
53	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.28080701
54	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.27510304
55	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.26517453
56	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.24766159
57	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.24018432
58	JUN_21703547_ChIP-Seq_K562_Human	1.23502293
59	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.22540444
60	VDR_23849224_ChIP-Seq_CD4+_Human	1.21533273
61	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.21063518
62	TCF4_23295773_ChIP-Seq_U87_Human	1.20547627
63	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.20249717
64	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.20249717
65	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.19922256
66	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.19225796
67	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.18252761
68	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.16598371
69	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.13421651
70	TP53_22573176_ChIP-Seq_HFKS_Human	1.13274454
71	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.12793128
72	P53_22387025_ChIP-Seq_ESCs_Mouse	1.12426800
73	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.11076391
74	CDX2_22108803_ChIP-Seq_LS180_Human	1.09121519
75	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.07290283
76	RUNX2_22187159_ChIP-Seq_PCA_Human	1.06707357
77	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.06041731
78	BCAT_22108803_ChIP-Seq_LS180_Human	1.05796408
79	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.05249442
80	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.05052230
81	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.04671997
82	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.03953958
83	TCF4_22108803_ChIP-Seq_LS180_Human	1.03723724
84	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.02075269
85	AR_20517297_ChIP-Seq_VCAP_Human	1.01753290
86	HTT_18923047_ChIP-ChIP_STHdh_Human	1.01673951
87	P300_18555785_Chip-Seq_ESCs_Mouse	0.99949775
88	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.99660372
89	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.99231862
90	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.98964465
91	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.98265904
92	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.98223104
93	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.97219133
94	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.96319749
95	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.95592138
96	MYC_18940864_ChIP-ChIP_HL60_Human	0.95438647
97	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.95013518
98	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.94987813
99	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.94628444
100	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.94628444

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004270_analgesia	3.25755268
2	MP0002102_abnormal_ear_morphology	3.22759233
3	MP0005451_abnormal_body_composition	2.98381779
4	MP0001529_abnormal_vocalization	2.86793901
5	MP0005367_renal/urinary_system_phenotyp	2.74530595
6	MP0000516_abnormal_urinary_system	2.74530595
7	MP0002938_white_spotting	2.56125687
8	MP0005187_abnormal_penis_morphology	2.43321546
9	MP0009046_muscle_twitch	2.19477861
10	MP0003121_genomic_imprinting	2.16106664
11	MP0001984_abnormal_olfaction	2.11559818
12	MP0003880_abnormal_central_pattern	2.09132347
13	MP0006276_abnormal_autonomic_nervous	2.07211408
14	MP0005645_abnormal_hypothalamus_physiol	2.07001725
15	MP0008058_abnormal_DNA_repair	2.04939843
16	MP0000372_irregular_coat_pigmentation	2.00834756
17	MP0000778_abnormal_nervous_system	1.93312577
18	MP0001968_abnormal_touch/_nociception	1.89579175
19	MP0002736_abnormal_nociception_after	1.87624173
20	MP0005248_abnormal_Harderian_gland	1.79963639
21	MP0006035_abnormal_mitochondrial_morpho	1.77557909
22	MP0003787_abnormal_imprinting	1.72990648
23	MP0002928_abnormal_bile_duct	1.69226146
24	MP0000647_abnormal_sebaceous_gland	1.69042678
25	MP0005551_abnormal_eye_electrophysiolog	1.64182812
26	MP0005174_abnormal_tail_pigmentation	1.62821612
27	MP0009745_abnormal_behavioral_response	1.58476492
28	MP0004215_abnormal_myocardial_fiber	1.58245605
29	MP0001486_abnormal_startle_reflex	1.58141936
30	MP0001986_abnormal_taste_sensitivity	1.51581772
31	MP0001764_abnormal_homeostasis	1.51188916
32	MP0004859_abnormal_synaptic_plasticity	1.49246068
33	MP0002751_abnormal_autonomic_nervous	1.47501968
34	MP0003123_paternal_imprinting	1.46953044
35	MP0006072_abnormal_retinal_apoptosis	1.46844689
36	MP0002735_abnormal_chemical_nociception	1.44724227
37	MP0002734_abnormal_mechanical_nocicepti	1.43731661
38	MP0002090_abnormal_vision	1.43279545
39	MP0003656_abnormal_erythrocyte_physiolo	1.42724862
40	MP0002332_abnormal_exercise_endurance	1.42341577
41	MP0003119_abnormal_digestive_system	1.38220699
42	MP0005253_abnormal_eye_physiology	1.38108930
43	MP0002095_abnormal_skin_pigmentation	1.35084530
44	MP0008872_abnormal_physiological_respon	1.34013217
45	MP0000639_abnormal_adrenal_gland	1.29333035
46	MP0002272_abnormal_nervous_system	1.26179347
47	MP0001270_distended_abdomen	1.25489264
48	MP0001905_abnormal_dopamine_level	1.21397281
49	MP0003950_abnormal_plasma_membrane	1.21328308
50	MP0006036_abnormal_mitochondrial_physio	1.19546995
51	MP0001293_anophthalmia	1.17434894
52	MP0003221_abnormal_cardiomyocyte_apopto	1.15144393
53	MP0003122_maternal_imprinting	1.14690475
54	MP0003937_abnormal_limbs/digits/tail_de	1.14148932
55	MP0002234_abnormal_pharynx_morphology	1.12881433
56	MP0002254_reproductive_system_inflammat	1.11813106
57	MP0003315_abnormal_perineum_morphology	1.11241903
58	MP0000569_abnormal_digit_pigmentation	1.11095902
59	MP0002909_abnormal_adrenal_gland	1.10380920
60	MP0004272_abnormal_basement_membrane	1.09874022
61	MP0006054_spinal_hemorrhage	1.08811915
62	MP0002572_abnormal_emotion/affect_behav	1.07442779
63	MP0003252_abnormal_bile_duct	1.03365604
64	MP0002184_abnormal_innervation	1.02983550
65	MP0001963_abnormal_hearing_physiology	1.01589673
66	MP0010094_abnormal_chromosome_stability	1.00412586
67	MP0002063_abnormal_learning/memory/cond	0.99356374
68	MP0002067_abnormal_sensory_capabilities	0.98468968
69	MP0005379_endocrine/exocrine_gland_phen	0.98392980
70	MP0003943_abnormal_hepatobiliary_system	0.97210073
71	MP0009780_abnormal_chondrocyte_physiolo	0.95421596
72	MP0000026_abnormal_inner_ear	0.95275378
73	MP0002752_abnormal_somatic_nervous	0.95246795
74	MP0004145_abnormal_muscle_electrophysio	0.94074165
75	MP0003011_delayed_dark_adaptation	0.93878565
76	MP0005646_abnormal_pituitary_gland	0.93084050
77	MP0005195_abnormal_posterior_eye	0.92865879
78	MP0002064_seizures	0.92164161
79	MP0000358_abnormal_cell_content/	0.91963604
80	MP0004134_abnormal_chest_morphology	0.91479028
81	MP0001756_abnormal_urination	0.91030390
82	MP0009697_abnormal_copulation	0.87686054
83	MP0002653_abnormal_ependyma_morphology	0.87324982
84	MP0008789_abnormal_olfactory_epithelium	0.86000487
85	MP0008877_abnormal_DNA_methylation	0.85683775
86	MP0004133_heterotaxia	0.85345908
87	MP0003635_abnormal_synaptic_transmissio	0.85004479
88	MP0005386_behavior/neurological_phenoty	0.84362155
89	MP0004924_abnormal_behavior	0.84362155
90	MP0000750_abnormal_muscle_regeneration	0.83770373
91	MP0000049_abnormal_middle_ear	0.81175106
92	MP0003861_abnormal_nervous_system	0.78669013
93	MP0003633_abnormal_nervous_system	0.78189236
94	MP0000631_abnormal_neuroendocrine_gland	0.76680818
95	MP0001485_abnormal_pinna_reflex	0.75112497
96	MP0003718_maternal_effect	0.74227674
97	MP0004142_abnormal_muscle_tone	0.73927249
98	MP0005266_abnormal_metabolism	0.73053950
99	MP0005083_abnormal_biliary_tract	0.72491514
100	MP0002163_abnormal_gland_morphology	0.69031072

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic fibrosis (HP:0100732)	4.81031732
2	Pancreatic cysts (HP:0001737)	4.49307264
3	Metaphyseal dysplasia (HP:0100255)	4.34433993
4	Aplasia/Hypoplasia of the tibia (HP:0005772)	4.00046608
5	Short tibia (HP:0005736)	3.99205015
6	Medial flaring of the eyebrow (HP:0010747)	3.81651243
7	Genital tract atresia (HP:0001827)	3.74454487
8	Gait imbalance (HP:0002141)	3.74371100
9	Congenital primary aphakia (HP:0007707)	3.70130416
10	True hermaphroditism (HP:0010459)	3.68918889
11	Nephrogenic diabetes insipidus (HP:0009806)	3.32349703
12	3-Methylglutaconic aciduria (HP:0003535)	3.31818423
13	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	3.31323379
14	Molar tooth sign on MRI (HP:0002419)	3.26355929
15	Abnormality of midbrain morphology (HP:0002418)	3.26355929
16	Aplasia/Hypoplasia of the tongue (HP:0010295)	3.18107999
17	Vaginal atresia (HP:0000148)	3.14828862
18	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.11819696
19	Abnormality of alanine metabolism (HP:0010916)	3.11819696
20	Hyperalaninemia (HP:0003348)	3.11819696
21	Cortical dysplasia (HP:0002539)	2.94271669
22	Abnormal biliary tract physiology (HP:0012439)	2.73549920
23	Bile duct proliferation (HP:0001408)	2.73549920
24	Specific learning disability (HP:0001328)	2.66702507
25	Progressive inability to walk (HP:0002505)	2.66034912
26	Delayed gross motor development (HP:0002194)	2.62836857
27	Methylmalonic acidemia (HP:0002912)	2.59300905
28	Chronic hepatic failure (HP:0100626)	2.58811475
29	Adrenal hypoplasia (HP:0000835)	2.55830551
30	Progressive macrocephaly (HP:0004481)	2.55000990
31	Acute necrotizing encephalopathy (HP:0006965)	2.52126581
32	Chorioretinal atrophy (HP:0000533)	2.51796742
33	Occipital encephalocele (HP:0002085)	2.48836166
34	Papillary thyroid carcinoma (HP:0002895)	2.47289174
35	Postaxial foot polydactyly (HP:0001830)	2.46834377
36	Microglossia (HP:0000171)	2.46454001
37	Abnormality of the renal medulla (HP:0100957)	2.45364803
38	Hepatoblastoma (HP:0002884)	2.44015447
39	Central scotoma (HP:0000603)	2.40897935
40	Thyroid carcinoma (HP:0002890)	2.39093294
41	Cystic liver disease (HP:0006706)	2.37906678
42	Retinal dysplasia (HP:0007973)	2.36705321
43	Nephronophthisis (HP:0000090)	2.31844572
44	Acute encephalopathy (HP:0006846)	2.27245266
45	Postaxial hand polydactyly (HP:0001162)	2.20323815
46	Astrocytoma (HP:0009592)	2.19023568
47	Abnormality of the astrocytes (HP:0100707)	2.19023568
48	Poor coordination (HP:0002370)	2.18875178
49	Oculomotor apraxia (HP:0000657)	2.14271310
50	Methylmalonic aciduria (HP:0012120)	2.12779504
51	Sclerocornea (HP:0000647)	2.12081055
52	Broad foot (HP:0001769)	2.11595582
53	Increased CSF lactate (HP:0002490)	2.10891705
54	Abnormal mitochondria in muscle tissue (HP:0008316)	2.10246655
55	Preaxial hand polydactyly (HP:0001177)	2.10017227
56	Steppage gait (HP:0003376)	2.09565619
57	Absent speech (HP:0001344)	2.04060015
58	Neoplasm of the adrenal cortex (HP:0100641)	2.03924957
59	Hyperglycinemia (HP:0002154)	2.03425846
60	Delayed CNS myelination (HP:0002188)	2.01955358
61	Abnormality of glycolysis (HP:0004366)	2.01935224
62	Pachygyria (HP:0001302)	2.01195698
63	Furrowed tongue (HP:0000221)	2.00199330
64	Drooling (HP:0002307)	1.98899631
65	Polyphagia (HP:0002591)	1.97956210
66	Aplasia/Hypoplasia of the fibula (HP:0006492)	1.96161275
67	Hyperventilation (HP:0002883)	1.95690145
68	Aplasia/Hypoplasia of the lens (HP:0008063)	1.94629311
69	Neuroendocrine neoplasm (HP:0100634)	1.92839958
70	Mitochondrial inheritance (HP:0001427)	1.92813610
71	Pheochromocytoma (HP:0002666)	1.92058140
72	Abnormality of serum amino acid levels (HP:0003112)	1.91947085
73	Increased corneal curvature (HP:0100692)	1.90977080
74	Keratoconus (HP:0000563)	1.90977080
75	Renal hypoplasia (HP:0000089)	1.90649813
76	Fibular aplasia (HP:0002990)	1.89396408
77	Hemiparesis (HP:0001269)	1.87808804
78	Increased serum pyruvate (HP:0003542)	1.87527795
79	Epidermoid cyst (HP:0200040)	1.87168644
80	Neoplasm of the liver (HP:0002896)	1.86447223
81	Cerebellar dysplasia (HP:0007033)	1.85843281
82	Abnormality of vitamin B metabolism (HP:0004340)	1.84271351
83	Dyschromatopsia (HP:0007641)	1.83548827
84	Inability to walk (HP:0002540)	1.83143733
85	Action tremor (HP:0002345)	1.81148864
86	Increased serum lactate (HP:0002151)	1.80996947
87	Hepatocellular necrosis (HP:0001404)	1.79565200
88	Amblyopia (HP:0000646)	1.78736811
89	Amyotrophic lateral sclerosis (HP:0007354)	1.77559278
90	Lissencephaly (HP:0001339)	1.77132047
91	Abnormality of the renal cortex (HP:0011035)	1.76374058
92	Flat face (HP:0012368)	1.75627393
93	Excessive salivation (HP:0003781)	1.74938155
94	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.72642435
95	Upper limb muscle weakness (HP:0003484)	1.72326255
96	Gastrointestinal atresia (HP:0002589)	1.70051834
97	Anencephaly (HP:0002323)	1.69981012
98	Generalized tonic-clonic seizures (HP:0002069)	1.68142828
99	Poor head control (HP:0002421)	1.66600000
100	Cerebral edema (HP:0002181)	1.64920176

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.72517254
2	ERBB3	3.54183733
3	BCR	3.50317472
4	MST1R	3.15349699
5	TRIM28	2.65013974
6	STK16	2.58063890
7	NEK1	2.55127205
8	CASK	2.51782172
9	RPS6KA4	2.38808257
10	WNK3	2.13424215
11	SRPK1	2.12947517
12	TNIK	2.10476515
13	MET	1.94666893
14	MAP4K2	1.90335664
15	MAP2K7	1.87289825
16	MAP3K4	1.79692433
17	CSNK1G2	1.67130594
18	STK38L	1.65100161
19	CSNK1G3	1.62547446
20	CSNK1A1L	1.61440662
21	NUAK1	1.61164829
22	GRK7	1.58421851
23	EIF2AK1	1.55417448
24	BCKDK	1.53234787
25	PIM2	1.52899589
26	MARK1	1.48392493
27	CSNK1G1	1.45165704
28	BMPR1B	1.42526534
29	FER	1.38446161
30	INSRR	1.35155260
31	STK39	1.31290651
32	EIF2AK3	1.29452583
33	PRKCE	1.25392408
34	NTRK3	1.24940419
35	PLK2	1.21824307
36	VRK2	1.12383942
37	PAK3	1.10218521
38	NME1	1.08201631
39	SIK3	1.07072933
40	EPHA4	1.05818214
41	LIMK1	1.05701616
42	MAPK13	1.00953195
43	WNK4	0.99918016
44	CDK3	0.94228871
45	DAPK2	0.90078671
46	PLK3	0.87694197
47	PINK1	0.85621684
48	LATS1	0.84772478
49	MKNK2	0.83480437
50	DYRK3	0.83325925
51	MST4	0.83238548
52	GRK5	0.82836680
53	BMX	0.82006662
54	MAP3K12	0.81828236
55	ADRBK2	0.80107460
56	TSSK6	0.74668090
57	BRSK2	0.73531214
58	FGFR2	0.72954814
59	VRK1	0.66357942
60	CDK19	0.63474306
61	FLT3	0.61866526
62	CCNB1	0.60758608
63	NTRK2	0.59438941
64	MAP3K2	0.59074383
65	CAMK2B	0.58282297
66	DYRK2	0.57592502
67	CAMK2D	0.57551084
68	CAMKK2	0.57407895
69	DAPK1	0.56825735
70	KSR1	0.53973091
71	GRK1	0.53222472
72	CAMK2A	0.52269182
73	PLK4	0.50714616
74	CDK6	0.50453973
75	MINK1	0.49754846
76	ADRBK1	0.49213791
77	TESK2	0.48428776
78	CSNK1A1	0.48039548
79	TESK1	0.47680954
80	BUB1	0.45498741
81	PTK2B	0.44040591
82	RPS6KA5	0.42885304
83	IGF1R	0.40329585
84	DYRK1B	0.39155396
85	PLK1	0.37345269
86	MYLK	0.36929899
87	PAK4	0.35816553
88	FGFR1	0.34783437
89	EGFR	0.34144866
90	OXSR1	0.33995375
91	CDK9	0.33022985
92	ABL1	0.32914708
93	PIK3CA	0.32569125
94	SGK223	0.32499027
95	SGK494	0.32499027
96	CAMK2G	0.32148973
97	EPHB2	0.31854128
98	RAF1	0.31530382
99	PRKCG	0.31219125
100	PHKG2	0.30332872

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.83439182
2	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	3.35861387
3	Protein export_Homo sapiens_hsa03060	3.27878502
4	Proteasome_Homo sapiens_hsa03050	3.17501076
5	Fatty acid elongation_Homo sapiens_hsa00062	2.98900589
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.70738186
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.29151187
8	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.23627661
9	Butanoate metabolism_Homo sapiens_hsa00650	2.20037494
10	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	2.15001681
11	Propanoate metabolism_Homo sapiens_hsa00640	2.07031408
12	Basal transcription factors_Homo sapiens_hsa03022	2.01829918
13	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.01317018
14	RNA polymerase_Homo sapiens_hsa03020	1.94513893
15	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.86557901
16	Phototransduction_Homo sapiens_hsa04744	1.86299828
17	Steroid biosynthesis_Homo sapiens_hsa00100	1.83644935
18	Nicotine addiction_Homo sapiens_hsa05033	1.81253867
19	Ether lipid metabolism_Homo sapiens_hsa00565	1.74652734
20	Oxidative phosphorylation_Homo sapiens_hsa00190	1.61748451
21	Parkinsons disease_Homo sapiens_hsa05012	1.60303871
22	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.59836734
23	GABAergic synapse_Homo sapiens_hsa04727	1.54322144
24	Peroxisome_Homo sapiens_hsa04146	1.51697028
25	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.39591047
26	Linoleic acid metabolism_Homo sapiens_hsa00591	1.31529045
27	Huntingtons disease_Homo sapiens_hsa05016	1.26720194
28	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.23871122
29	Fatty acid metabolism_Homo sapiens_hsa01212	1.20891046
30	Glutamatergic synapse_Homo sapiens_hsa04724	1.18306138
31	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.16778949
32	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.06067910
33	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.05797624
34	Homologous recombination_Homo sapiens_hsa03440	1.05429531
35	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.05212116
36	Pyrimidine metabolism_Homo sapiens_hsa00240	1.05102175
37	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.03258806
38	Mismatch repair_Homo sapiens_hsa03430	0.99802620
39	Fanconi anemia pathway_Homo sapiens_hsa03460	0.98978313
40	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.97725805
41	Alzheimers disease_Homo sapiens_hsa05010	0.97640668
42	Olfactory transduction_Homo sapiens_hsa04740	0.96912072
43	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.96695481
44	Nucleotide excision repair_Homo sapiens_hsa03420	0.92665371
45	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.91719618
46	Dopaminergic synapse_Homo sapiens_hsa04728	0.88409422
47	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.84422493
48	Serotonergic synapse_Homo sapiens_hsa04726	0.83509184
49	Purine metabolism_Homo sapiens_hsa00230	0.83312325
50	RNA degradation_Homo sapiens_hsa03018	0.82771057
51	Pyruvate metabolism_Homo sapiens_hsa00620	0.80591735
52	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.80444882
53	Non-homologous end-joining_Homo sapiens_hsa03450	0.80334576
54	Circadian entrainment_Homo sapiens_hsa04713	0.79385609
55	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.77599774
56	Regulation of autophagy_Homo sapiens_hsa04140	0.76879676
57	Axon guidance_Homo sapiens_hsa04360	0.74654461
58	Circadian rhythm_Homo sapiens_hsa04710	0.73854250
59	Cocaine addiction_Homo sapiens_hsa05030	0.73011019
60	Nitrogen metabolism_Homo sapiens_hsa00910	0.72341620
61	Metabolic pathways_Homo sapiens_hsa01100	0.72084947
62	Collecting duct acid secretion_Homo sapiens_hsa04966	0.71804029
63	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.70930813
64	p53 signaling pathway_Homo sapiens_hsa04115	0.70710523
65	RNA transport_Homo sapiens_hsa03013	0.69816489
66	Spliceosome_Homo sapiens_hsa03040	0.67630541
67	Oocyte meiosis_Homo sapiens_hsa04114	0.66921953
68	Folate biosynthesis_Homo sapiens_hsa00790	0.66844371
69	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.65449082
70	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.65015917
71	Morphine addiction_Homo sapiens_hsa05032	0.64687249
72	Taste transduction_Homo sapiens_hsa04742	0.64414650
73	Retinol metabolism_Homo sapiens_hsa00830	0.63907239
74	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.63334008
75	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.62306759
76	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.58505388
77	beta-Alanine metabolism_Homo sapiens_hsa00410	0.55839778
78	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.53107047
79	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.52802543
80	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.46747997
81	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.44711304
82	Base excision repair_Homo sapiens_hsa03410	0.42306027
83	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.42240363
84	Tryptophan metabolism_Homo sapiens_hsa00380	0.42091715
85	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.42054017
86	Alcoholism_Homo sapiens_hsa05034	0.41576160
87	Glutathione metabolism_Homo sapiens_hsa00480	0.40721057
88	Insulin secretion_Homo sapiens_hsa04911	0.39221735
89	Chemical carcinogenesis_Homo sapiens_hsa05204	0.39170243
90	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.37519518
91	Gap junction_Homo sapiens_hsa04540	0.36077389
92	Long-term depression_Homo sapiens_hsa04730	0.35374373
93	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.35092861
94	Glycerolipid metabolism_Homo sapiens_hsa00561	0.35084781
95	Hippo signaling pathway_Homo sapiens_hsa04390	0.35067589
96	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.34125742
97	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.33996850
98	Adherens junction_Homo sapiens_hsa04520	0.31190048
99	Sphingolipid metabolism_Homo sapiens_hsa00600	0.30618718
100	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.30471804

ZNF355P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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