ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	synaptic vesicle docking involved in exocytosis (GO:0016081)	5.07112307
2	glutamate secretion (GO:0014047)	4.14696935
3	positive regulation of synapse maturation (GO:0090129)	3.76888835
4	synaptic vesicle maturation (GO:0016188)	3.75805649
5	sodium ion export (GO:0071436)	3.74052708
6	cellular potassium ion homeostasis (GO:0030007)	3.72914904
7	synaptic vesicle exocytosis (GO:0016079)	3.70486674
8	locomotory exploration behavior (GO:0035641)	3.52429506
9	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.38609443
10	regulation of synaptic vesicle exocytosis (GO:2000300)	3.37524267
11	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.35858193
12	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	3.29273683
13	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	3.28515148
14	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	3.28382102
15	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	3.18684413
16	neuronal ion channel clustering (GO:0045161)	3.17140898
17	cell communication by electrical coupling (GO:0010644)	3.15627624
18	creatine metabolic process (GO:0006600)	3.15209457
19	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.12288162
20	cerebellar granule cell differentiation (GO:0021707)	3.09675943
21	regulation of synapse maturation (GO:0090128)	3.09130273
22	postsynaptic membrane organization (GO:0001941)	3.08024689
23	dendritic spine morphogenesis (GO:0060997)	3.06638025
24	cell migration in hindbrain (GO:0021535)	3.01234159
25	cytoskeletal anchoring at plasma membrane (GO:0007016)	3.00108509
26	regulation of synapse structural plasticity (GO:0051823)	2.95106691
27	negative regulation of catenin import into nucleus (GO:0035414)	2.92481418
28	positive regulation of dendritic spine development (GO:0060999)	2.89179765
29	protein retention in ER lumen (GO:0006621)	2.87881356
30	regulation of neuronal synaptic plasticity (GO:0048168)	2.86738945
31	neuromuscular process controlling balance (GO:0050885)	2.84696573
32	regulation of synaptic vesicle transport (GO:1902803)	2.82982805
33	planar cell polarity pathway involved in neural tube closure (GO:0090179)	2.82909606
34	cell-cell junction maintenance (GO:0045217)	2.79378203
35	dendritic spine organization (GO:0097061)	2.78971983
36	cardiac myofibril assembly (GO:0055003)	2.75996825
37	axon ensheathment in central nervous system (GO:0032291)	2.74033441
38	central nervous system myelination (GO:0022010)	2.74033441
39	cerebellar Purkinje cell layer development (GO:0021680)	2.72212397
40	vocalization behavior (GO:0071625)	2.69967775
41	regulation of early endosome to late endosome transport (GO:2000641)	2.68774022
42	sarcoplasmic reticulum calcium ion transport (GO:0070296)	2.66392885
43	muscle filament sliding (GO:0030049)	2.64962437
44	actin-myosin filament sliding (GO:0033275)	2.64962437
45	neurotransmitter secretion (GO:0007269)	2.63820687
46	exploration behavior (GO:0035640)	2.62299187
47	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.62096059
48	cardiac muscle contraction (GO:0060048)	2.59075471
49	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.56601825
50	regulation of glutamate receptor signaling pathway (GO:1900449)	2.54062878
51	synaptic vesicle endocytosis (GO:0048488)	2.53413995
52	layer formation in cerebral cortex (GO:0021819)	2.53340574
53	activation of protein kinase A activity (GO:0034199)	2.52086514
54	myofibril assembly (GO:0030239)	2.51257214
55	potassium ion homeostasis (GO:0055075)	2.50164026
56	adherens junction assembly (GO:0034333)	2.49346847
57	dopamine receptor signaling pathway (GO:0007212)	2.48777052
58	neuronal action potential propagation (GO:0019227)	2.47666949
59	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	2.44528091
60	potassium ion import (GO:0010107)	2.43951774
61	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	2.43504543
62	protein targeting to plasma membrane (GO:0072661)	2.42247583
63	regulation of voltage-gated calcium channel activity (GO:1901385)	2.42003483
64	myelination in peripheral nervous system (GO:0022011)	2.41969035
65	peripheral nervous system axon ensheathment (GO:0032292)	2.41969035
66	positive regulation of dendrite development (GO:1900006)	2.40132845
67	negative regulation of cell size (GO:0045792)	2.36490584
68	establishment of mitochondrion localization (GO:0051654)	2.36383609
69	regulation of long-term neuronal synaptic plasticity (GO:0048169)	2.36039852
70	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.35617936
71	axon extension (GO:0048675)	2.33962550
72	amino acid import (GO:0043090)	2.33320106
73	cellular response to catecholamine stimulus (GO:0071870)	2.32992624
74	cellular response to monoamine stimulus (GO:0071868)	2.32992624
75	tooth mineralization (GO:0034505)	2.32910657
76	G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)	2.32217487
77	response to parathyroid hormone (GO:0071107)	2.30942406
78	respiratory system process (GO:0003016)	2.30291080
79	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.29532335
80	mitochondrion transport along microtubule (GO:0047497)	2.29532335
81	cochlea morphogenesis (GO:0090103)	2.29474339
82	regulation of synaptic plasticity (GO:0048167)	2.29303423
83	skeletal muscle fiber development (GO:0048741)	2.28578954
84	barbed-end actin filament capping (GO:0051016)	2.28280357
85	L-amino acid import (GO:0043092)	2.27426455
86	semaphorin-plexin signaling pathway (GO:0071526)	2.26102171
87	striated muscle contraction (GO:0006941)	2.25551061
88	regulation of ARF protein signal transduction (GO:0032012)	2.25372286
89	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	2.25282172
90	protein heterotrimerization (GO:0070208)	2.25073907
91	neurotransmitter-gated ion channel clustering (GO:0072578)	2.22939693
92	regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)	2.22124001
93	cellular sodium ion homeostasis (GO:0006883)	2.21003753
94	NADH metabolic process (GO:0006734)	2.20671720
95	endothelial cell chemotaxis (GO:0035767)	2.18377443
96	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	2.18374075
97	virion attachment to host cell (GO:0019062)	2.18310357
98	adhesion of symbiont to host cell (GO:0044650)	2.18310357
99	focal adhesion assembly (GO:0048041)	2.17710280
100	cell-substrate adherens junction assembly (GO:0007045)	2.17710280

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	3.52401606
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.90658940
3	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.87547181
4	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.80529307
5	LXR_22292898_ChIP-Seq_THP-1_Human	2.77945698
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.70687866
7	ERG_21242973_ChIP-ChIP_JURKAT_Human	2.52604047
8	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.30155589
9	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.29745526
10	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.29745526
11	ZFP281_18757296_ChIP-ChIP_E14_Mouse	2.28183510
12	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.25245529
13	KDM2B_26808549_Chip-Seq_K562_Human	2.24089363
14	KDM2B_26808549_Chip-Seq_SUP-B15_Human	2.16705485
15	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.10744508
16	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.09228321
17	SUZ12_27294783_Chip-Seq_ESCs_Mouse	2.08680539
18	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.05892101
19	MTF2_20144788_ChIP-Seq_MESCs_Mouse	2.00228506
20	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.99930858
21	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.99304874
22	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.97672648
23	CTCF_27219007_Chip-Seq_Bcells_Human	1.97094395
24	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.95135123
25	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.94674709
26	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.94326174
27	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.93767469
28	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.93044095
29	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.90487861
30	* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.90285711
31	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.89039773
32	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.88705193
33	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.87612379
34	DROSHA_22980978_ChIP-Seq_HELA_Human	1.86633854
35	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.83684355
36	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.82092830
37	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.79599341
38	RACK7_27058665_Chip-Seq_MCF-7_Human	1.78653025
39	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.77571813
40	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.72049357
41	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.69179413
42	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.67776530
43	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.67156417
44	KDM2B_26808549_Chip-Seq_DND41_Human	1.66866222
45	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.64965063
46	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.64100051
47	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.59924842
48	P68_20966046_ChIP-Seq_HELA_Human	1.57870394
49	ZFP281_27345836_Chip-Seq_ESCs_Mouse	1.57741508
50	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.56637450
51	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.55004475
52	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.48959187
53	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.46788242
54	SMC4_20622854_ChIP-Seq_HELA_Human	1.46693065
55	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.45624464
56	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.44267774
57	CREB1_26743006_Chip-Seq_LNCaP_Human	1.42976549
58	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.42102507
59	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.41386943
60	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.41246063
61	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.40976115
62	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.37074921
63	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.36908945
64	TET1_21490601_ChIP-Seq_MESCs_Mouse	1.35951170
65	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	1.35171354
66	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.34858422
67	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.33354380
68	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.32572683
69	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.31492783
70	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.26288745
71	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.23366200
72	VDR_21846776_ChIP-Seq_THP-1_Human	1.22719587
73	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.22682432
74	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.21570101
75	SMC3_22415368_ChIP-Seq_MEFs_Mouse	1.21146189
76	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.20710676
77	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.18267622
78	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.17645004
79	ZNF263_19887448_ChIP-Seq_K562_Human	1.16094883
80	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.14162542
81	CLOCK_20551151_ChIP-Seq_293T_Human	1.13494844
82	TCF7_22412390_ChIP-Seq_EML_Mouse	1.12963201
83	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.12872678
84	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.12835615
85	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.12485857
86	REST_21632747_ChIP-Seq_MESCs_Mouse	1.12101693
87	SETDB1_19884255_ChIP-Seq_MESCs_Mouse	1.11245340
88	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.08484162
89	SMC1_22415368_ChIP-Seq_MEFs_Mouse	1.07948942
90	SA1_27219007_Chip-Seq_Bcells_Human	1.06435729
91	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.03714354
92	TP53_23651856_ChIP-Seq_MEFs_Mouse	1.02577780
93	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.01341219
94	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.99031826
95	TBX20_22328084_ChIP-Seq_HEART_Mouse	0.97940921
96	TBX20_22080862_ChIP-Seq_HEART_Mouse	0.97940921
97	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	0.97806356
98	OCT4_19829295_ChIP-Seq_ESCs_Human	0.97078155
99	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.96816614
100	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.96648697

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004859_abnormal_synaptic_plasticity	4.23149247
2	MP0000751_myopathy	3.43282494
3	MP0003705_abnormal_hypodermis_morpholog	3.09561722
4	MP0004270_analgesia	2.76378984
5	MP0004858_abnormal_nervous_system	2.32650608
6	MP0005670_abnormal_white_adipose	2.17552160
7	MP0002249_abnormal_larynx_morphology	2.16931598
8	MP0003635_abnormal_synaptic_transmissio	2.16908991
9	MP0008438_abnormal_cutaneous_collagen	2.13958883
10	MP0003283_abnormal_digestive_organ	2.12746452
11	MP0004145_abnormal_muscle_electrophysio	2.05855978
12	MP0005423_abnormal_somatic_nervous	2.01696070
13	MP0003329_amyloid_beta_deposits	1.99118942
14	MP0003880_abnormal_central_pattern	1.99073355
15	MP0003879_abnormal_hair_cell	1.97935980
16	MP0003279_aneurysm	1.85823878
17	MP0010030_abnormal_orbit_morphology	1.82067617
18	MP0009780_abnormal_chondrocyte_physiolo	1.79805324
19	MP0004130_abnormal_muscle_cell	1.76894448
20	MP0002064_seizures	1.76198012
21	MP0000749_muscle_degeneration	1.75519213
22	MP0002063_abnormal_learning/memory/cond	1.75386547
23	MP0005623_abnormal_meninges_morphology	1.71725127
24	MP0000747_muscle_weakness	1.61594645
25	MP0009379_abnormal_foot_pigmentation	1.61400287
26	MP0000759_abnormal_skeletal_muscle	1.60767657
27	MP0002734_abnormal_mechanical_nocicepti	1.54653142
28	MP0005409_darkened_coat_color	1.54022497
29	MP0008569_lethality_at_weaning	1.53536190
30	MP0003123_paternal_imprinting	1.47957981
31	MP0005503_abnormal_tendon_morphology	1.46938507
32	MP0002822_catalepsy	1.46581312
33	MP0004087_abnormal_muscle_fiber	1.44078623
34	MP0001958_emphysema	1.43720608
35	MP0010368_abnormal_lymphatic_system	1.33107831
36	MP0002572_abnormal_emotion/affect_behav	1.31421168
37	MP0000003_abnormal_adipose_tissue	1.30793772
38	MP0009745_abnormal_behavioral_response	1.29661231
39	MP0000733_abnormal_muscle_development	1.27596901
40	MP0000778_abnormal_nervous_system	1.27566878
41	MP0005257_abnormal_intraocular_pressure	1.27163390
42	MP0000678_abnormal_parathyroid_gland	1.25608377
43	MP0003634_abnormal_glial_cell	1.25158035
44	MP0000750_abnormal_muscle_regeneration	1.24914073
45	MP0002272_abnormal_nervous_system	1.24335579
46	MP0001486_abnormal_startle_reflex	1.23537203
47	MP0005375_adipose_tissue_phenotype	1.23392191
48	MP0005666_abnormal_adipose_tissue	1.22809945
49	MP0004036_abnormal_muscle_relaxation	1.21801286
50	MP0001502_abnormal_circadian_rhythm	1.21161298
51	MP0002106_abnormal_muscle_physiology	1.20172204
52	MP0005058_abnormal_lysosome_morphology	1.17390421
53	MP0000566_synostosis	1.14621878
54	MP0000013_abnormal_adipose_tissue	1.14113697
55	MP0002108_abnormal_muscle_morphology	1.13329430
56	MP0005369_muscle_phenotype	1.13007997
57	MP0004510_myositis	1.12635984
58	MP0006138_congestive_heart_failure	1.12418998
59	MP0001849_ear_inflammation	1.11772655
60	MP0004272_abnormal_basement_membrane	1.10464157
61	MP0002089_abnormal_postnatal_growth/wei	1.08954808
62	MP0000049_abnormal_middle_ear	1.08807067
63	MP0002733_abnormal_thermal_nociception	1.08734387
64	MP0001970_abnormal_pain_threshold	1.07478902
65	MP0000534_abnormal_ureter_morphology	1.05976641
66	MP0001348_abnormal_lacrimal_gland	1.04990782
67	MP0005620_abnormal_muscle_contractility	1.04561811
68	MP0000955_abnormal_spinal_cord	1.03935953
69	MP0003646_muscle_fatigue	1.03793631
70	MP0005330_cardiomyopathy	1.03199153
71	MP0005508_abnormal_skeleton_morphology	1.01304148
72	MP0003690_abnormal_glial_cell	1.00936262
73	MP0003137_abnormal_impulse_conducting	1.00897657
74	MP0001440_abnormal_grooming_behavior	0.98367729
75	MP0001299_abnormal_eye_distance/	0.97936770
76	MP0004811_abnormal_neuron_physiology	0.94639367
77	MP0009250_abnormal_appendicular_skeleto	0.93253015
78	MP0004233_abnormal_muscle_weight	0.93123067
79	MP0000462_abnormal_digestive_system	0.92806366
80	MP0002066_abnormal_motor_capabilities/c	0.92420955
81	MP0004185_abnormal_adipocyte_glucose	0.92414692
82	MP0000681_abnormal_thyroid_gland	0.92382800
83	MP0000920_abnormal_myelination	0.91339870
84	MP0001346_abnormal_lacrimal_gland	0.91047073
85	MP0002882_abnormal_neuron_morphology	0.87827530
86	MP0003075_altered_response_to	0.87582340
87	MP0002896_abnormal_bone_mineralization	0.87435619
88	MP0002557_abnormal_social/conspecific_i	0.87417162
89	MP0003942_abnormal_urinary_system	0.85816060
90	MP0004885_abnormal_endolymph	0.85042192
91	MP0005451_abnormal_body_composition	0.82517384
92	MP0009840_abnormal_foam_cell	0.81400299
93	MP0002269_muscular_atrophy	0.81060247
94	MP0006276_abnormal_autonomic_nervous	0.80352360
95	MP0003633_abnormal_nervous_system	0.79549680
96	MP0009384_cardiac_valve_regurgitation	0.79537949
97	MP0010630_abnormal_cardiac_muscle	0.79465120
98	MP0005167_abnormal_blood-brain_barrier	0.78201696
99	MP0002932_abnormal_joint_morphology	0.77760211
100	MP0005595_abnormal_vascular_smooth	0.77573491

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Type 1 muscle fiber predominance (HP:0003803)	4.49939143
2	Protrusio acetabuli (HP:0003179)	3.80900468
3	Obstructive sleep apnea (HP:0002870)	3.61854301
4	Myokymia (HP:0002411)	3.56405597
5	Increased variability in muscle fiber diameter (HP:0003557)	3.35612967
6	Exercise-induced myalgia (HP:0003738)	3.33097247
7	Muscle fiber inclusion bodies (HP:0100299)	3.30262931
8	Myopathic facies (HP:0002058)	3.29191793
9	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	3.20435954
10	Nemaline bodies (HP:0003798)	3.19077535
11	Abnormality of skeletal muscle fiber size (HP:0012084)	3.10793290
12	Shallow orbits (HP:0000586)	2.96425317
13	Round ear (HP:0100830)	2.91416353
14	Turricephaly (HP:0000262)	2.85281043
15	Distal lower limb muscle weakness (HP:0009053)	2.79805093
16	Spinal rigidity (HP:0003306)	2.79724645
17	Increased connective tissue (HP:0009025)	2.79668246
18	Centrally nucleated skeletal muscle fibers (HP:0003687)	2.74674446
19	Neurofibrillary tangles (HP:0002185)	2.70946901
20	Premature rupture of membranes (HP:0001788)	2.69703104
21	Muscle fiber splitting (HP:0003555)	2.65146499
22	Hyporeflexia of lower limbs (HP:0002600)	2.64896961
23	Cerebral aneurysm (HP:0004944)	2.63055339
24	Hyperacusis (HP:0010780)	2.63035148
25	Mildly elevated creatine phosphokinase (HP:0008180)	2.62358243
26	Ankle clonus (HP:0011448)	2.59633834
27	Supranuclear gaze palsy (HP:0000605)	2.54672179
28	Stridor (HP:0010307)	2.53981675
29	Broad metatarsal (HP:0001783)	2.41150214
30	Asymmetric septal hypertrophy (HP:0001670)	2.37262106
31	Lower limb amyotrophy (HP:0007210)	2.36270435
32	Cerebral inclusion bodies (HP:0100314)	2.35370013
33	Distal lower limb amyotrophy (HP:0008944)	2.30687455
34	Bundle branch block (HP:0011710)	2.28495807
35	Achilles tendon contracture (HP:0001771)	2.25417198
36	Bulbar palsy (HP:0001283)	2.23760728
37	Insomnia (HP:0100785)	2.21184152
38	Bladder diverticulum (HP:0000015)	2.15803191
39	Mitral regurgitation (HP:0001653)	2.14163962
40	Distal upper limb amyotrophy (HP:0007149)	2.13832641
41	Upper limb amyotrophy (HP:0009129)	2.13832641
42	Annular pancreas (HP:0001734)	2.13257889
43	Slender build (HP:0001533)	2.12422714
44	Torticollis (HP:0000473)	2.08617969
45	EMG: myopathic abnormalities (HP:0003458)	2.08561006
46	Ulnar bowing (HP:0003031)	2.07270231
47	Distal arthrogryposis (HP:0005684)	2.07119741
48	Lymphangioma (HP:0100764)	2.06431103
49	Myotonia (HP:0002486)	2.06285999
50	Abnormal atrioventricular conduction (HP:0005150)	2.06153734
51	Vertebral compression fractures (HP:0002953)	2.02862136
52	Muscle stiffness (HP:0003552)	2.02688805
53	Foot dorsiflexor weakness (HP:0009027)	2.02517200
54	Abnormality of the Achilles tendon (HP:0005109)	2.00705185
55	Sudden death (HP:0001699)	2.00551704
56	Calcaneovalgus deformity (HP:0001848)	2.00276425
57	Ulnar deviation of the wrist (HP:0003049)	2.00161175
58	Hypoventilation (HP:0002791)	1.98929120
59	Visual hallucinations (HP:0002367)	1.98467208
60	Abnormality of the aortic arch (HP:0012303)	1.97808056
61	Difficulty running (HP:0009046)	1.95599253
62	Subaortic stenosis (HP:0001682)	1.94427264
63	Abnormality of the left ventricular outflow tract (HP:0011103)	1.94427264
64	Aplasia involving bones of the upper limbs (HP:0009823)	1.94275147
65	Aplasia of the phalanges of the hand (HP:0009802)	1.94275147
66	Aplasia involving bones of the extremities (HP:0009825)	1.94275147
67	Heart block (HP:0012722)	1.93719343
68	Congenital malformation of the right heart (HP:0011723)	1.92891767
69	Double outlet right ventricle (HP:0001719)	1.92891767
70	Difficulty climbing stairs (HP:0003551)	1.92870558
71	Abnormality of the foot musculature (HP:0001436)	1.91217093
72	Fragile skin (HP:0001030)	1.90694685
73	Exercise-induced muscle cramps (HP:0003710)	1.87964507
74	Axonal loss (HP:0003447)	1.87217477
75	Hypercortisolism (HP:0001578)	1.85098280
76	Neck muscle weakness (HP:0000467)	1.85001783
77	Hyperthyroidism (HP:0000836)	1.84598071
78	Abnormality of the calf musculature (HP:0001430)	1.82994322
79	Abnormality of binocular vision (HP:0011514)	1.79962513
80	Diplopia (HP:0000651)	1.79962513
81	Ankle contracture (HP:0006466)	1.79558270
82	Sleep apnea (HP:0010535)	1.78228453
83	Muscle hypertrophy of the lower extremities (HP:0008968)	1.77529206
84	Action tremor (HP:0002345)	1.77448001
85	Bronchomalacia (HP:0002780)	1.76840018
86	Focal dystonia (HP:0004373)	1.76726068
87	Abnormal eating behavior (HP:0100738)	1.76611229
88	Deformed tarsal bones (HP:0008119)	1.74112240
89	Craniofacial dystonia (HP:0012179)	1.74041479
90	Truncus arteriosus (HP:0001660)	1.73977412
91	Vascular tortuosity (HP:0004948)	1.73704275
92	Genu recurvatum (HP:0002816)	1.73591366
93	Focal motor seizures (HP:0011153)	1.72952860
94	Hyperparathyroidism (HP:0000843)	1.72790440
95	Nuclear cataract (HP:0100018)	1.72192117
96	Coronal craniosynostosis (HP:0004440)	1.71910455
97	EMG: neuropathic changes (HP:0003445)	1.71525703
98	Focal seizures (HP:0007359)	1.70615215
99	Bowel diverticulosis (HP:0005222)	1.68427721
100	Partial duplication of the phalanx of hand (HP:0009999)	1.65581438

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIB3	3.53665140
2	PRKD3	3.07909502
3	RIPK1	2.75531816
4	TTN	2.58016929
5	EPHA4	2.36449992
6	MARK1	2.35229695
7	PHKG1	2.26806065
8	PHKG2	2.26806065
9	PRPF4B	2.17276235
10	PAK6	2.17190610
11	ICK	2.12439816
12	SIK1	2.03106077
13	NTRK3	2.00064053
14	NTRK1	1.99874796
15	ARAF	1.82697666
16	EPHB2	1.81797463
17	TESK1	1.76641264
18	OBSCN	1.66541670
19	EEF2K	1.64893459
20	SMG1	1.59120809
21	LATS2	1.55034068
22	UHMK1	1.50143456
23	DDR2	1.49706037
24	MAP3K11	1.47948837
25	DAPK2	1.46714751
26	PDGFRA	1.46599026
27	TYRO3	1.45120426
28	MARK2	1.41115342
29	LIMK1	1.39959949
30	NTRK2	1.35999604
31	ERN1	1.33694420
32	CAMKK1	1.27123663
33	MAPK12	1.22991683
34	GRK5	1.19188879
35	DMPK	1.18124110
36	LMTK2	1.06674004
37	PTK2	1.04889739
38	BRAF	1.02688979
39	CAMK1	1.00579704
40	TAOK2	0.99867810
41	MAP3K9	0.99755664
42	RPS6KA2	0.99346538
43	CAMK2G	0.97737965
44	PRKD2	0.90605301
45	CDC42BPA	0.87154390
46	MINK1	0.86201124
47	CDK5	0.85690154
48	CAMK2B	0.85337710
49	CDK11A	0.83906553
50	DAPK3	0.83458832
51	CDK15	0.81754127
52	PDPK1	0.81336191
53	SIK2	0.80697377
54	MOS	0.79483497
55	KSR2	0.77292187
56	ABL2	0.76063381
57	MAP3K7	0.75914829
58	SGK494	0.75134846
59	SGK223	0.75134846
60	PRKG2	0.74808464
61	PKN1	0.74548883
62	CDK18	0.72628897
63	PRKCH	0.70443128
64	DYRK1B	0.70307321
65	STK38	0.69839060
66	NME2	0.69811613
67	MTOR	0.69442613
68	IRAK3	0.68337125
69	PKN2	0.67147494
70	MYLK	0.63882809
71	CDK14	0.63801790
72	CAMK2D	0.63679463
73	ROCK2	0.63616748
74	MAPK4	0.63325832
75	ROCK1	0.62910295
76	FGFR4	0.60470255
77	PINK1	0.60442129
78	MAP2K4	0.59544143
79	RPS6KL1	0.59525884
80	RPS6KC1	0.59525884
81	MAP3K6	0.58913231
82	ILK	0.58038774
83	CAMK4	0.57679623
84	TIE1	0.57353777
85	MAP3K1	0.57212862
86	STK11	0.56558446
87	SGK3	0.55083780
88	TAOK1	0.51876293
89	IRAK2	0.51867883
90	FGFR2	0.51694402
91	HIPK2	0.51640186
92	AKT2	0.51126247
93	CDK19	0.50999320
94	EPHA2	0.50763101
95	PAK2	0.50713140
96	BMX	0.50691181
97	MUSK	0.50033673
98	MAPK7	0.49899515
99	MAPK10	0.49718696
100	PRKD1	0.49374618

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	2.35940015
2	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.32828553
3	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.97230175
4	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.82631694
5	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.81986892
6	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.78183368
7	Long-term potentiation_Homo sapiens_hsa04720	1.74785458
8	Insulin secretion_Homo sapiens_hsa04911	1.73363905
9	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.71313600
10	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.57856521
11	Prion diseases_Homo sapiens_hsa05020	1.54897087
12	Gastric acid secretion_Homo sapiens_hsa04971	1.51378967
13	Cardiac muscle contraction_Homo sapiens_hsa04260	1.50877395
14	Cocaine addiction_Homo sapiens_hsa05030	1.50637064
15	Circadian entrainment_Homo sapiens_hsa04713	1.49946937
16	Amphetamine addiction_Homo sapiens_hsa05031	1.47710186
17	Sulfur relay system_Homo sapiens_hsa04122	1.44293771
18	Notch signaling pathway_Homo sapiens_hsa04330	1.41560343
19	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.41201351
20	Arginine and proline metabolism_Homo sapiens_hsa00330	1.39685430
21	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.39566406
22	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.38890905
23	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.34339151
24	Dopaminergic synapse_Homo sapiens_hsa04728	1.33102372
25	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.30053782
26	GnRH signaling pathway_Homo sapiens_hsa04912	1.28014327
27	Glutamatergic synapse_Homo sapiens_hsa04724	1.27188555
28	Cholinergic synapse_Homo sapiens_hsa04725	1.25356718
29	Melanogenesis_Homo sapiens_hsa04916	1.24947422
30	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.22719955
31	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.22394622
32	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.22290096
33	GABAergic synapse_Homo sapiens_hsa04727	1.21718442
34	Glioma_Homo sapiens_hsa05214	1.20808973
35	Nicotine addiction_Homo sapiens_hsa05033	1.20158161
36	Arginine biosynthesis_Homo sapiens_hsa00220	1.14740274
37	VEGF signaling pathway_Homo sapiens_hsa04370	1.13993635
38	Morphine addiction_Homo sapiens_hsa05032	1.13219765
39	Axon guidance_Homo sapiens_hsa04360	1.13059388
40	Insulin signaling pathway_Homo sapiens_hsa04910	1.11572477
41	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.09850311
42	AMPK signaling pathway_Homo sapiens_hsa04152	1.09055679
43	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.08439586
44	Calcium signaling pathway_Homo sapiens_hsa04020	1.05923369
45	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.05276469
46	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.03458438
47	Renin secretion_Homo sapiens_hsa04924	1.02743947
48	Glucagon signaling pathway_Homo sapiens_hsa04922	1.02522269
49	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.01739393
50	cAMP signaling pathway_Homo sapiens_hsa04024	1.00778850
51	Phospholipase D signaling pathway_Homo sapiens_hsa04072	1.00293784
52	Estrogen signaling pathway_Homo sapiens_hsa04915	0.99873420
53	Focal adhesion_Homo sapiens_hsa04510	0.99473467
54	ECM-receptor interaction_Homo sapiens_hsa04512	0.98131150
55	Bile secretion_Homo sapiens_hsa04976	0.96672534
56	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.96546277
57	Gap junction_Homo sapiens_hsa04540	0.96541924
58	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.93635039
59	Vibrio cholerae infection_Homo sapiens_hsa05110	0.92676810
60	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.92416039
61	Phenylalanine metabolism_Homo sapiens_hsa00360	0.90826101
62	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.89834581
63	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.89116446
64	Salivary secretion_Homo sapiens_hsa04970	0.88166142
65	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.82959093
66	ErbB signaling pathway_Homo sapiens_hsa04012	0.82282171
67	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.79835628
68	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.77028912
69	PPAR signaling pathway_Homo sapiens_hsa03320	0.75296496
70	Basal cell carcinoma_Homo sapiens_hsa05217	0.74850631
71	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.74002409
72	Galactose metabolism_Homo sapiens_hsa00052	0.73313842
73	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.73189600
74	Protein digestion and absorption_Homo sapiens_hsa04974	0.71609920
75	Long-term depression_Homo sapiens_hsa04730	0.69141047
76	Tight junction_Homo sapiens_hsa04530	0.68880857
77	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.68538886
78	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.64789484
79	mTOR signaling pathway_Homo sapiens_hsa04150	0.64406303
80	Pentose phosphate pathway_Homo sapiens_hsa00030	0.64148070
81	Rap1 signaling pathway_Homo sapiens_hsa04015	0.63876691
82	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.63832105
83	Bladder cancer_Homo sapiens_hsa05219	0.63048292
84	Histidine metabolism_Homo sapiens_hsa00340	0.62167479
85	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.62097473
86	Amoebiasis_Homo sapiens_hsa05146	0.62081857
87	MAPK signaling pathway_Homo sapiens_hsa04010	0.61402773
88	Hippo signaling pathway_Homo sapiens_hsa04390	0.60916726
89	Other glycan degradation_Homo sapiens_hsa00511	0.60362452
90	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.56883336
91	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.56745460
92	Endocytosis_Homo sapiens_hsa04144	0.55965666
93	Endometrial cancer_Homo sapiens_hsa05213	0.54983912
94	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.54887156
95	Wnt signaling pathway_Homo sapiens_hsa04310	0.53784960
96	Carbon metabolism_Homo sapiens_hsa01200	0.53307714
97	Proteoglycans in cancer_Homo sapiens_hsa05205	0.50885734
98	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.49844376
99	Pancreatic secretion_Homo sapiens_hsa04972	0.48340455
100	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.48042081

ZNF358

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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