ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cell migration in hindbrain (GO:0021535)	4.65867077
2	planar cell polarity pathway involved in neural tube closure (GO:0090179)	3.70699257
3	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	3.63651587
4	pyrimidine nucleobase catabolic process (GO:0006208)	3.56647681
5	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	3.48616070
6	establishment of mitochondrion localization (GO:0051654)	3.41012827
7	negative regulation of cell size (GO:0045792)	3.34010745
8	vocalization behavior (GO:0071625)	3.25947530
9	generation of neurons (GO:0048699)	3.25824400
10	mitochondrion transport along microtubule (GO:0047497)	3.21037127
11	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	3.21037127
12	regulation of female receptivity (GO:0045924)	3.20412048
13	axonal fasciculation (GO:0007413)	3.13858726
14	neuron cell-cell adhesion (GO:0007158)	3.06223421
15	lymph vessel development (GO:0001945)	3.04337484
16	camera-type eye morphogenesis (GO:0048593)	2.96703602
17	layer formation in cerebral cortex (GO:0021819)	2.96402413
18	postsynaptic membrane organization (GO:0001941)	2.92739983
19	neuron recognition (GO:0008038)	2.89785383
20	presynaptic membrane organization (GO:0097090)	2.89631012
21	positive regulation of synapse maturation (GO:0090129)	2.86899142
22	G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)	2.82672898
23	positive regulation of amino acid transport (GO:0051957)	2.81007991
24	synaptic vesicle exocytosis (GO:0016079)	2.79018493
25	regulation of synaptic vesicle exocytosis (GO:2000300)	2.77114867
26	cell-cell junction maintenance (GO:0045217)	2.76577414
27	presynaptic membrane assembly (GO:0097105)	2.75781679
28	protein localization to synapse (GO:0035418)	2.74128194
29	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.72111027
30	lens morphogenesis in camera-type eye (GO:0002089)	2.71534705
31	cardiac ventricle formation (GO:0003211)	2.67933853
32	regulation of synapse structural plasticity (GO:0051823)	2.67911968
33	neurotransmitter-gated ion channel clustering (GO:0072578)	2.64603775
34	dendritic spine morphogenesis (GO:0060997)	2.63019878
35	regulation of glutamate receptor signaling pathway (GO:1900449)	2.62810877
36	neuronal ion channel clustering (GO:0045161)	2.62586781
37	intracellular estrogen receptor signaling pathway (GO:0030520)	2.61854728
38	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.61305651
39	negative regulation of erythrocyte differentiation (GO:0045647)	2.60780107
40	negative regulation of glial cell proliferation (GO:0060253)	2.60189969
41	spinal cord development (GO:0021510)	2.60135942
42	heart valve formation (GO:0003188)	2.58972444
43	cerebellar granule cell differentiation (GO:0021707)	2.58749005
44	negative regulation of catenin import into nucleus (GO:0035414)	2.58383112
45	nucleosome disassembly (GO:0006337)	2.57897711
46	protein-DNA complex disassembly (GO:0032986)	2.57897711
47	cochlea morphogenesis (GO:0090103)	2.57781623
48	synaptic vesicle maturation (GO:0016188)	2.57173905
49	cardiac muscle cell proliferation (GO:0060038)	2.56608803
50	protein heterotrimerization (GO:0070208)	2.56347398
51	positive regulation of synapse assembly (GO:0051965)	2.54438355
52	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)	2.54246287
53	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.51953794
54	3-UTR-mediated mRNA stabilization (GO:0070935)	2.50944778
55	regulation of synapse maturation (GO:0090128)	2.50399790
56	locomotory exploration behavior (GO:0035641)	2.49385915
57	endocardial cushion morphogenesis (GO:0003203)	2.49151388
58	female mating behavior (GO:0060180)	2.48975434
59	dendritic spine organization (GO:0097061)	2.48941970
60	regulation of respiratory system process (GO:0044065)	2.48748273
61	dermatan sulfate metabolic process (GO:0030205)	2.48569195
62	regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)	2.46746620
63	neuron projection extension involved in neuron projection guidance (GO:1902284)	2.46575088
64	axon extension involved in axon guidance (GO:0048846)	2.46575088
65	phosphatidylglycerol biosynthetic process (GO:0006655)	2.46193414
66	cranial nerve morphogenesis (GO:0021602)	2.45837583
67	cardiac chamber formation (GO:0003207)	2.45529002
68	positive regulation of CREB transcription factor activity (GO:0032793)	2.44544459
69	axon extension (GO:0048675)	2.43404523
70	cell migration involved in heart development (GO:0060973)	2.43144291
71	activation of protein kinase A activity (GO:0034199)	2.42726800
72	regulation of synaptic vesicle transport (GO:1902803)	2.38732615
73	regulation of somitogenesis (GO:0014807)	2.37399996
74	somatic stem cell division (GO:0048103)	2.36744741
75	convergent extension (GO:0060026)	2.35761928
76	glutamate secretion (GO:0014047)	2.33616567
77	regulation of glycogen (starch) synthase activity (GO:2000465)	2.32851703
78	regulation of establishment of planar polarity (GO:0090175)	2.32337298
79	Wnt signaling pathway, planar cell polarity pathway (GO:0060071)	2.30532999
80	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.29268192
81	regulation of ARF GTPase activity (GO:0032312)	2.29007353
82	mesenchyme morphogenesis (GO:0072132)	2.28877868
83	cell communication by electrical coupling (GO:0010644)	2.28376988
84	nucleobase catabolic process (GO:0046113)	2.27791549
85	positive regulation of vascular permeability (GO:0043117)	2.27749987
86	cellular response to vascular endothelial growth factor stimulus (GO:0035924)	2.26930812
87	atrioventricular valve morphogenesis (GO:0003181)	2.24454096
88	limb bud formation (GO:0060174)	2.23830259
89	striated muscle cell proliferation (GO:0014855)	2.20276696
90	semaphorin-plexin signaling pathway (GO:0071526)	2.19909198
91	exploration behavior (GO:0035640)	2.19602169
92	histone H4 deacetylation (GO:0070933)	2.19307766
93	cell junction maintenance (GO:0034331)	2.18521190
94	neuromuscular process controlling balance (GO:0050885)	2.18325870
95	central nervous system projection neuron axonogenesis (GO:0021952)	2.17608807
96	enteric nervous system development (GO:0048484)	2.17061849
97	apical protein localization (GO:0045176)	2.16784486
98	negative regulation of axonogenesis (GO:0050771)	2.16079972
99	cardiac myofibril assembly (GO:0055003)	2.15824296
100	short-term memory (GO:0007614)	2.15569411

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.05100164
2	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	3.03358987
3	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.60248060
4	KDM2B_26808549_Chip-Seq_SUP-B15_Human	2.55654086
5	DROSHA_22980978_ChIP-Seq_HELA_Human	2.46784040
6	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.42749250
7	ZFP281_18757296_ChIP-ChIP_E14_Mouse	2.39782274
8	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.35823167
9	* KDM2B_26808549_Chip-Seq_DND41_Human	2.35796945
10	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.31336870
11	LXR_22292898_ChIP-Seq_THP-1_Human	2.29140929
12	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.28368526
13	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.23507336
14	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.23507336
15	RNF2_27304074_Chip-Seq_ESCs_Mouse	2.23006262
16	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	2.18061750
17	SUZ12_27294783_Chip-Seq_ESCs_Mouse	2.15522703
18	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.09656959
19	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.07816242
20	ERG_21242973_ChIP-ChIP_JURKAT_Human	2.06555268
21	* KDM2B_26808549_Chip-Seq_K562_Human	2.05730428
22	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.03788013
23	DNAJC2_21179169_ChIP-ChIP_NT2_Human	2.02079656
24	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	2.01736296
25	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	2.01691060
26	* KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.94966985
27	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.90423860
28	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.89576124
29	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.88376193
30	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.87485143
31	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.80577974
32	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.79781709
33	TCF7_22412390_ChIP-Seq_EML_Mouse	1.79470463
34	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.79458950
35	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.78812661
36	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.77764375
37	VDR_21846776_ChIP-Seq_THP-1_Human	1.77686056
38	ZFP281_27345836_Chip-Seq_ESCs_Mouse	1.77678862
39	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.77269998
40	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.76760925
41	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.73138631
42	CTCF_27219007_Chip-Seq_Bcells_Human	1.72162931
43	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.71350424
44	* ELK3_25401928_ChIP-Seq_HUVEC_Human	1.70603533
45	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.67116486
46	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.64974128
47	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.63324595
48	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.57325807
49	* KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.56965622
50	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.56492304
51	MYC_22102868_ChIP-Seq_BL_Human	1.53185236
52	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.52160627
53	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.47864207
54	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.44719359
55	* SA1_27219007_Chip-Seq_ERYTHROID_Human	1.43428485
56	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.42574848
57	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.39903880
58	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.36560765
59	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.36257690
60	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.36044837
61	DMRT1_23473982_ChIP-Seq_TESTES_Mouse	1.32749283
62	REST_21632747_ChIP-Seq_MESCs_Mouse	1.32373811
63	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.31725869
64	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.31562932
65	SMC4_20622854_ChIP-Seq_HELA_Human	1.28311692
66	* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.27945178
67	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.27441882
68	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.26379043
69	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.25815621
70	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.25484609
71	* RACK7_27058665_Chip-Seq_MCF-7_Human	1.25316426
72	CREB1_26743006_Chip-Seq_LNCaP_Human	1.23926044
73	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.23832951
74	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.23195764
75	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.19480092
76	* CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.18010093
77	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.15332422
78	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.15291406
79	P68_20966046_ChIP-Seq_HELA_Human	1.13055197
80	ISL1_27105846_Chip-Seq_CPCs_Mouse	1.10200673
81	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.07821657
82	SCL_19346495_ChIP-Seq_HPC-7_Human	1.07300749
83	TET1_21490601_ChIP-Seq_MESCs_Mouse	1.04181944
84	SOX3_22085726_ChIP-Seq_NPCs_Mouse	1.04067850
85	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.03350920
86	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.01850839
87	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.00802283
88	SMC1_22415368_ChIP-Seq_MEFs_Mouse	1.00791009
89	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	1.00092976
90	SMC3_22415368_ChIP-Seq_MEFs_Mouse	0.99659705
91	TRIM28_21343339_ChIP-Seq_HEK293_Human	0.96675063
92	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.95893840
93	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.95420900
94	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.93265573
95	UTX_26944678_Chip-Seq_JUKART_Human	0.90849123
96	OCT4_19829295_ChIP-Seq_ESCs_Human	0.90515650
97	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	0.90460862
98	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	0.90460862
99	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	0.90460862
100	VDR_24763502_ChIP-Seq_THP-1_Human	0.89785705

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004859_abnormal_synaptic_plasticity	3.62735662
2	MP0009278_abnormal_bone_marrow	2.61054139
3	MP0003122_maternal_imprinting	2.37673448
4	MP0002822_catalepsy	2.33316205
5	MP0010030_abnormal_orbit_morphology	2.32948361
6	MP0003279_aneurysm	2.22168892
7	MP0005503_abnormal_tendon_morphology	2.17606156
8	MP0002249_abnormal_larynx_morphology	2.12115265
9	MP0005423_abnormal_somatic_nervous	2.11584196
10	MP0002653_abnormal_ependyma_morphology	2.06442000
11	MP0005670_abnormal_white_adipose	1.96475363
12	MP0003635_abnormal_synaptic_transmissio	1.96215532
13	MP0000778_abnormal_nervous_system	1.95814432
14	MP0000751_myopathy	1.90945267
15	MP0000049_abnormal_middle_ear	1.86068116
16	MP0009384_cardiac_valve_regurgitation	1.79935723
17	MP0008438_abnormal_cutaneous_collagen	1.77005161
18	MP0004858_abnormal_nervous_system	1.71071749
19	MP0002063_abnormal_learning/memory/cond	1.66869268
20	MP0003878_abnormal_ear_physiology	1.63018358
21	MP0005377_hearing/vestibular/ear_phenot	1.63018358
22	MP0004270_analgesia	1.62380933
23	MP0003880_abnormal_central_pattern	1.57874029
24	MP0001849_ear_inflammation	1.54735084
25	MP0003283_abnormal_digestive_organ	1.53881415
26	MP0001486_abnormal_startle_reflex	1.48384993
27	MP0000566_synostosis	1.48275743
28	MP0008569_lethality_at_weaning	1.47375743
29	MP0001958_emphysema	1.46618424
30	MP0000955_abnormal_spinal_cord	1.44884566
31	MP0003938_abnormal_ear_development	1.44816724
32	MP0002572_abnormal_emotion/affect_behav	1.42196696
33	MP0004133_heterotaxia	1.40763210
34	MP0002932_abnormal_joint_morphology	1.39537738
35	MP0010368_abnormal_lymphatic_system	1.38221934
36	MP0003705_abnormal_hypodermis_morpholog	1.36932387
37	MP0002064_seizures	1.31661395
38	MP0005275_abnormal_skin_tensile	1.31185590
39	MP0000534_abnormal_ureter_morphology	1.29206409
40	MP0006138_congestive_heart_failure	1.27418935
41	MP0002116_abnormal_craniofacial_bone	1.27077037
42	MP0003172_abnormal_lysosome_physiology	1.26835352
43	MP0002108_abnormal_muscle_morphology	1.25197176
44	MP0003787_abnormal_imprinting	1.23128152
45	MP0006292_abnormal_olfactory_placode	1.22896421
46	MP0003385_abnormal_body_wall	1.22298427
47	MP0002557_abnormal_social/conspecific_i	1.20390850
48	MP0002152_abnormal_brain_morphology	1.12593633
49	MP0004811_abnormal_neuron_physiology	1.12493342
50	MP0000026_abnormal_inner_ear	1.10095598
51	MP0009745_abnormal_behavioral_response	1.09189488
52	MP0004885_abnormal_endolymph	1.08311025
53	MP0000733_abnormal_muscle_development	1.06815252
54	MP0001879_abnormal_lymphatic_vessel	1.06206255
55	MP0003942_abnormal_urinary_system	1.05888586
56	MP0005508_abnormal_skeleton_morphology	1.05564003
57	MP0006276_abnormal_autonomic_nervous	1.05531093
58	MP0001502_abnormal_circadian_rhythm	1.05442996
59	MP0003861_abnormal_nervous_system	1.04727541
60	MP0002733_abnormal_thermal_nociception	1.04715632
61	MP0005171_absent_coat_pigmentation	1.03947626
62	MP0000767_abnormal_smooth_muscle	1.03574533
63	MP0002882_abnormal_neuron_morphology	1.03043040
64	MP0003121_genomic_imprinting	1.00767160
65	MP0000462_abnormal_digestive_system	1.00267772
66	MP0009250_abnormal_appendicular_skeleto	0.99623809
67	MP0002272_abnormal_nervous_system	0.99496665
68	MP0009379_abnormal_foot_pigmentation	0.97472438
69	MP0002089_abnormal_postnatal_growth/wei	0.96888108
70	MP0005623_abnormal_meninges_morphology	0.96484621
71	MP0000631_abnormal_neuroendocrine_gland	0.96436619
72	MP0001270_distended_abdomen	0.96430313
73	MP0001970_abnormal_pain_threshold	0.95787313
74	MP0009053_abnormal_anal_canal	0.94097399
75	MP0000537_abnormal_urethra_morphology	0.93288339
76	MP0001299_abnormal_eye_distance/	0.93251271
77	MP0002184_abnormal_innervation	0.91896991
78	MP0001968_abnormal_touch/_nociception	0.91762591
79	MP0005257_abnormal_intraocular_pressure	0.91370222
80	MP0001346_abnormal_lacrimal_gland	0.91178931
81	MP0004381_abnormal_hair_follicle	0.91120807
82	MP0002127_abnormal_cardiovascular_syste	0.90265553
83	MP0003329_amyloid_beta_deposits	0.89758598
84	MP0002734_abnormal_mechanical_nocicepti	0.89239394
85	MP0001963_abnormal_hearing_physiology	0.88046055
86	MP0003634_abnormal_glial_cell	0.87756518
87	MP0003115_abnormal_respiratory_system	0.87628077
88	MP0002752_abnormal_somatic_nervous	0.86488041
89	MP0004130_abnormal_muscle_cell	0.85947970
90	MP0002114_abnormal_axial_skeleton	0.85287663
91	MP0002067_abnormal_sensory_capabilities	0.84691742
92	MP0008260_abnormal_autophagy	0.84584835
93	MP0002735_abnormal_chemical_nociception	0.83172303
94	MP0005394_taste/olfaction_phenotype	0.79499272
95	MP0005499_abnormal_olfactory_system	0.79499272
96	MP0005409_darkened_coat_color	0.77876917
97	MP0005645_abnormal_hypothalamus_physiol	0.77748988
98	MP0008789_abnormal_olfactory_epithelium	0.77699015
99	MP0002081_perinatal_lethality	0.77151448
100	MP0003137_abnormal_impulse_conducting	0.76768500

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Obstructive sleep apnea (HP:0002870)	4.33254252
2	Shallow orbits (HP:0000586)	3.62300201
3	Abnormality of the aortic arch (HP:0012303)	3.17889971
4	Sleep apnea (HP:0010535)	2.92524620
5	Hyperacusis (HP:0010780)	2.89075563
6	Supernumerary ribs (HP:0005815)	2.80632926
7	Broad metatarsal (HP:0001783)	2.78306602
8	Spinal canal stenosis (HP:0003416)	2.70863297
9	Neoplasm of the heart (HP:0100544)	2.69763395
10	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.69296256
11	Peripheral hypomyelination (HP:0007182)	2.66914015
12	Myokymia (HP:0002411)	2.65851260
13	Neonatal short-limb short stature (HP:0008921)	2.61660993
14	Protrusio acetabuli (HP:0003179)	2.60804124
15	Cerebral aneurysm (HP:0004944)	2.56583544
16	Annular pancreas (HP:0001734)	2.53785823
17	Ankle clonus (HP:0011448)	2.47384583
18	Short 4th metacarpal (HP:0010044)	2.45593390
19	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.45593390
20	Lower limb asymmetry (HP:0100559)	2.42726577
21	Turricephaly (HP:0000262)	2.41302700
22	Abnormality of the parietal bone (HP:0002696)	2.39172048
23	Bladder diverticulum (HP:0000015)	2.37693749
24	Lymphangioma (HP:0100764)	2.34349009
25	Cervical subluxation (HP:0003308)	2.31898137
26	Narrow nasal bridge (HP:0000446)	2.29926484
27	Biconcave vertebral bodies (HP:0004586)	2.29468518
28	Wide anterior fontanel (HP:0000260)	2.28477843
29	Supernumerary bones of the axial skeleton (HP:0009144)	2.26820901
30	Trigonocephaly (HP:0000243)	2.23144698
31	Broad face (HP:0000283)	2.21689928
32	Vitreoretinal degeneration (HP:0000655)	2.20490700
33	Renovascular hypertension (HP:0100817)	2.19505167
34	Ulnar claw (HP:0001178)	2.18785793
35	Morphological abnormality of the middle ear (HP:0008609)	2.18392142
36	Hypoventilation (HP:0002791)	2.16748033
37	Abnormality of binocular vision (HP:0011514)	2.11838619
38	Diplopia (HP:0000651)	2.11838619
39	Increased variability in muscle fiber diameter (HP:0003557)	2.09598392
40	Thin ribs (HP:0000883)	2.06222604
41	Disproportionate tall stature (HP:0001519)	2.05329091
42	Bronchomalacia (HP:0002780)	2.05175141
43	Abnormality of the 4th metacarpal (HP:0010012)	2.04729378
44	Genu recurvatum (HP:0002816)	2.02822205
45	Hypoplasia of the iris (HP:0007676)	2.02637642
46	Pointed chin (HP:0000307)	2.01334964
47	Arnold-Chiari malformation (HP:0002308)	2.01138410
48	Abnormality of the intervertebral disk (HP:0005108)	2.00941751
49	Broad phalanges of the hand (HP:0009768)	1.98498853
50	Hypoplastic ischia (HP:0003175)	1.97897113
51	Centrally nucleated skeletal muscle fibers (HP:0003687)	1.95160009
52	Precocious puberty (HP:0000826)	1.91204202
53	Abnormality of the pubic bones (HP:0003172)	1.90685827
54	Broad finger (HP:0001500)	1.90492095
55	Broad thumb (HP:0011304)	1.90086515
56	Abnormality of the ischium (HP:0003174)	1.87309543
57	Mitral regurgitation (HP:0001653)	1.86462200
58	Supranuclear gaze palsy (HP:0000605)	1.84702831
59	Broad long bones (HP:0005622)	1.84149979
60	Round ear (HP:0100830)	1.83146307
61	Insomnia (HP:0100785)	1.81830527
62	Alacrima (HP:0000522)	1.81452756
63	Broad phalanx (HP:0006009)	1.81008912
64	Focal motor seizures (HP:0011153)	1.80313074
65	Bowel diverticulosis (HP:0005222)	1.79977143
66	Genetic anticipation (HP:0003743)	1.79873076
67	High anterior hairline (HP:0009890)	1.79508599
68	Abnormality of dentin (HP:0010299)	1.77818532
69	Abnormality of the lower motor neuron (HP:0002366)	1.77490672
70	Pulmonary artery stenosis (HP:0004415)	1.77443027
71	Broad palm (HP:0001169)	1.77263230
72	Heterochromia iridis (HP:0001100)	1.77097967
73	Abnormality of skeletal muscle fiber size (HP:0012084)	1.74848045
74	Broad hallux (HP:0010055)	1.74712977
75	Abnormal hair whorl (HP:0010721)	1.74419633
76	Renal duplication (HP:0000075)	1.73208575
77	Abnormality of the columella (HP:0009929)	1.73154503
78	Tracheomalacia (HP:0002779)	1.72769669
79	Abnormality of the radial head (HP:0003995)	1.71610416
80	Infantile muscular hypotonia (HP:0008947)	1.69920865
81	Aplasia involving bones of the extremities (HP:0009825)	1.69415172
82	Aplasia involving bones of the upper limbs (HP:0009823)	1.69415172
83	Aplasia of the phalanges of the hand (HP:0009802)	1.69415172
84	Premature rupture of membranes (HP:0001788)	1.69040628
85	Visceral angiomatosis (HP:0100761)	1.68910521
86	Joint laxity (HP:0001388)	1.67567186
87	Mitral valve prolapse (HP:0001634)	1.66243967
88	Broad distal phalanx of finger (HP:0009836)	1.66208664
89	Venous insufficiency (HP:0005293)	1.65995511
90	Stereotypic behavior (HP:0000733)	1.65562961
91	Partial duplication of the phalanx of hand (HP:0009999)	1.61208790
92	Broad toe (HP:0001837)	1.60723737
93	Exercise-induced myalgia (HP:0003738)	1.60393844
94	Epileptic encephalopathy (HP:0200134)	1.59972441
95	Cutaneous syndactyly (HP:0012725)	1.59812145
96	Focal seizures (HP:0007359)	1.59669205
97	Overriding aorta (HP:0002623)	1.58920763
98	Spina bifida occulta (HP:0003298)	1.58915132
99	Deviation of the hallux (HP:0010051)	1.58847292
100	Abnormality of the anterior chamber (HP:0000593)	1.58148039

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	SIK2	3.02173954
2	TRIB3	2.86718343
3	MARK1	2.86177313
4	NTRK2	2.51306990
5	MARK2	2.35740021
6	SIK1	2.17490161
7	MAP3K11	2.11559262
8	DYRK1B	1.91870809
9	UHMK1	1.83907956
10	MAP3K10	1.76711950
11	TNK2	1.65923069
12	EPHB2	1.64850509
13	CAMKK1	1.52762775
14	PRKD2	1.49378178
15	SIK3	1.44943080
16	TYRO3	1.38870427
17	PRPF4B	1.38486381
18	PRKD3	1.32900825
19	CDK12	1.32417113
20	PKN2	1.25970941
21	ICK	1.25282824
22	MAP3K7	1.23387533
23	FGFR2	1.22988847
24	DYRK2	1.13899251
25	EPHA4	1.12615031
26	MAPK13	1.11725911
27	BRD4	1.11004215
28	CAMK1	1.10943656
29	PAK6	1.10751771
30	RIPK1	1.10683056
31	MAPK12	1.10190625
32	CAMK4	1.09502210
33	EEF2K	1.09064129
34	NTRK1	1.08412918
35	CDK19	1.06117137
36	TIE1	1.04885142
37	MAP3K6	1.04245811
38	TESK1	1.03919789
39	GRK6	1.03357400
40	PDGFRA	1.02733203
41	RPS6KA2	1.02053867
42	CASK	1.01688402
43	ERN1	0.99185779
44	PINK1	0.98796545
45	MAP4K1	0.97333519
46	STK38	0.95238059
47	MAP2K4	0.90582686
48	RPS6KL1	0.89906738
49	RPS6KC1	0.89906738
50	MAPK7	0.89768641
51	PKN1	0.89467772
52	FES	0.89249206
53	EPHA3	0.83470107
54	CDK5	0.82029605
55	CDC42BPA	0.82026845
56	DMPK	0.81688955
57	MAP2K2	0.81523110
58	HIPK2	0.80940861
59	EPHB1	0.79917746
60	MTOR	0.78725987
61	PRKD1	0.76355259
62	RET	0.76237584
63	RPS6KA6	0.74245914
64	MAP2K3	0.73430774
65	MINK1	0.70098333
66	KDR	0.68457593
67	FGFR4	0.67868514
68	DDR2	0.64690252
69	DAPK2	0.63442751
70	MAP4K2	0.61467104
71	KIT	0.61267763
72	SMG1	0.60043160
73	LRRK2	0.60022621
74	ERBB2	0.59858874
75	PRKCZ	0.59558979
76	TAOK1	0.58257681
77	PRKCH	0.57424061
78	MAP2K7	0.56676022
79	TTN	0.55708241
80	MAPK4	0.54985814
81	MAPK15	0.53980837
82	SGK494	0.53576568
83	SGK223	0.53576568
84	CAMK1D	0.50839867
85	CDK14	0.50224893
86	DYRK1A	0.50088385
87	ZAP70	0.49031838
88	CDK11A	0.48529565
89	STK11	0.48506143
90	BTK	0.46804631
91	CDK15	0.45684359
92	PTK6	0.45436622
93	ROCK1	0.45316329
94	ROCK2	0.44931306
95	CAMK2B	0.44790975
96	NTRK3	0.43637712
97	BCKDK	0.43497881
98	MAPK9	0.42469815
99	MAPK8	0.42349211
100	MAP3K1	0.42310251

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Notch signaling pathway_Homo sapiens_hsa04330	2.50955252
2	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	2.02946688
3	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.82203667
4	Basal cell carcinoma_Homo sapiens_hsa05217	1.77338320
5	Axon guidance_Homo sapiens_hsa04360	1.76579521
6	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.76128227
7	Circadian entrainment_Homo sapiens_hsa04713	1.68130899
8	Melanogenesis_Homo sapiens_hsa04916	1.60593336
9	Phospholipase D signaling pathway_Homo sapiens_hsa04072	1.57707673
10	Cocaine addiction_Homo sapiens_hsa05030	1.53831386
11	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.49049394
12	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.45947051
13	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.45412896
14	Long-term potentiation_Homo sapiens_hsa04720	1.43430274
15	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.41133843
16	Cholinergic synapse_Homo sapiens_hsa04725	1.40814554
17	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.40741528
18	Acute myeloid leukemia_Homo sapiens_hsa05221	1.39696424
19	Glutamatergic synapse_Homo sapiens_hsa04724	1.38911623
20	Colorectal cancer_Homo sapiens_hsa05210	1.35137522
21	Morphine addiction_Homo sapiens_hsa05032	1.34987616
22	Dopaminergic synapse_Homo sapiens_hsa04728	1.32928017
23	Nicotine addiction_Homo sapiens_hsa05033	1.32639632
24	Neurotrophin signaling pathway_Homo sapiens_hsa04722	1.29690539
25	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.28694124
26	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	1.27661568
27	Endometrial cancer_Homo sapiens_hsa05213	1.27268592
28	Wnt signaling pathway_Homo sapiens_hsa04310	1.26200853
29	GABAergic synapse_Homo sapiens_hsa04727	1.25967141
30	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.25380639
31	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.23312934
32	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.22732569
33	Amphetamine addiction_Homo sapiens_hsa05031	1.21950700
34	Gastric acid secretion_Homo sapiens_hsa04971	1.21129575
35	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.19800504
36	Glioma_Homo sapiens_hsa05214	1.18927120
37	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.18099393
38	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.17203789
39	Non-small cell lung cancer_Homo sapiens_hsa05223	1.17103669
40	cAMP signaling pathway_Homo sapiens_hsa04024	1.17094996
41	Renin secretion_Homo sapiens_hsa04924	1.16570001
42	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.14145499
43	Choline metabolism in cancer_Homo sapiens_hsa05231	1.13683242
44	VEGF signaling pathway_Homo sapiens_hsa04370	1.13501733
45	Rap1 signaling pathway_Homo sapiens_hsa04015	1.12320764
46	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.11301793
47	Hippo signaling pathway_Homo sapiens_hsa04390	1.10655884
48	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	1.10070589
49	Estrogen signaling pathway_Homo sapiens_hsa04915	1.09245511
50	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.06798560
51	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.05276160
52	AMPK signaling pathway_Homo sapiens_hsa04152	1.04147551
53	Ras signaling pathway_Homo sapiens_hsa04014	1.02364753
54	GnRH signaling pathway_Homo sapiens_hsa04912	1.01482831
55	ErbB signaling pathway_Homo sapiens_hsa04012	1.00688948
56	Lysine degradation_Homo sapiens_hsa00310	1.00279303
57	Gap junction_Homo sapiens_hsa04540	0.97695138
58	MAPK signaling pathway_Homo sapiens_hsa04010	0.97688115
59	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.97098065
60	Focal adhesion_Homo sapiens_hsa04510	0.96873676
61	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.95332278
62	Calcium signaling pathway_Homo sapiens_hsa04020	0.94402714
63	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.93842562
64	Endocytosis_Homo sapiens_hsa04144	0.93241675
65	Insulin signaling pathway_Homo sapiens_hsa04910	0.91189009
66	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.91053262
67	Salivary secretion_Homo sapiens_hsa04970	0.90554751
68	Long-term depression_Homo sapiens_hsa04730	0.90546293
69	Pancreatic cancer_Homo sapiens_hsa05212	0.89562720
70	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.89415420
71	mTOR signaling pathway_Homo sapiens_hsa04150	0.89239952
72	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.86849467
73	Adherens junction_Homo sapiens_hsa04520	0.86457485
74	Renal cell carcinoma_Homo sapiens_hsa05211	0.86248538
75	ECM-receptor interaction_Homo sapiens_hsa04512	0.85715471
76	Platelet activation_Homo sapiens_hsa04611	0.85291874
77	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.83420812
78	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.81601274
79	Insulin secretion_Homo sapiens_hsa04911	0.79427916
80	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.79108965
81	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.74326423
82	Amoebiasis_Homo sapiens_hsa05146	0.71500912
83	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.70979932
84	Pathways in cancer_Homo sapiens_hsa05200	0.70842861
85	Prostate cancer_Homo sapiens_hsa05215	0.70034510
86	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.69241328
87	Tight junction_Homo sapiens_hsa04530	0.64180498
88	Taste transduction_Homo sapiens_hsa04742	0.62676934
89	Vibrio cholerae infection_Homo sapiens_hsa05110	0.62630197
90	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.61224299
91	FoxO signaling pathway_Homo sapiens_hsa04068	0.60127444
92	Serotonergic synapse_Homo sapiens_hsa04726	0.60059697
93	Glucagon signaling pathway_Homo sapiens_hsa04922	0.59019105
94	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.58694397
95	Cardiac muscle contraction_Homo sapiens_hsa04260	0.58336204
96	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.57737144
97	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.56689053
98	Thyroid cancer_Homo sapiens_hsa05216	0.54106433
99	Osteoclast differentiation_Homo sapiens_hsa04380	0.53680652
100	Prion diseases_Homo sapiens_hsa05020	0.53199181

ZNF362

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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