ZNF365

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes several isoforms which have different expression patterns and functions. Mutation in this gene is associated with uric acid nephrolithiasis (UAN). Alternatively spliced variants, encoding distinct proteins, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)8.13884820
2synaptic vesicle maturation (GO:0016188)8.04630824
3glutamate secretion (GO:0014047)7.18238527
4regulation of short-term neuronal synaptic plasticity (GO:0048172)6.62740423
5synaptic vesicle exocytosis (GO:0016079)6.36493055
6regulation of synaptic vesicle exocytosis (GO:2000300)6.17491835
7membrane depolarization during cardiac muscle cell action potential (GO:0086012)6.06776503
8cellular potassium ion homeostasis (GO:0030007)5.75681019
9regulation of synaptic vesicle transport (GO:1902803)5.45616916
10sodium ion export (GO:0071436)5.44493359
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.33848453
12neurotransmitter secretion (GO:0007269)5.22607291
13neuronal action potential propagation (GO:0019227)5.19457678
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.07922418
15locomotory exploration behavior (GO:0035641)4.85250248
16L-amino acid import (GO:0043092)4.75026537
17regulation of neuronal synaptic plasticity (GO:0048168)4.70444157
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.64293506
19synaptic transmission, glutamatergic (GO:0035249)4.47371112
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.43407644
21regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.38990421
22neurotransmitter transport (GO:0006836)4.34980457
23cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.32677415
24central nervous system myelination (GO:0022010)4.32211347
25axon ensheathment in central nervous system (GO:0032291)4.32211347
26cerebellar granule cell differentiation (GO:0021707)4.29943994
27gamma-aminobutyric acid signaling pathway (GO:0007214)4.28441680
28regulation of long-term neuronal synaptic plasticity (GO:0048169)4.28075673
29neuron-neuron synaptic transmission (GO:0007270)4.22508296
30exploration behavior (GO:0035640)4.17843416
31vocalization behavior (GO:0071625)4.16211224
32negative regulation of synaptic transmission, GABAergic (GO:0032229)4.11636535
33gamma-aminobutyric acid transport (GO:0015812)4.08961937
34regulation of voltage-gated calcium channel activity (GO:1901385)4.08783492
35amino acid import (GO:0043090)4.08575940
36regulation of neurotransmitter secretion (GO:0046928)4.04986893
37protein localization to synapse (GO:0035418)4.01845437
38synaptic vesicle endocytosis (GO:0048488)3.97957022
39glutamate receptor signaling pathway (GO:0007215)3.96547397
40positive regulation of synapse maturation (GO:0090129)3.93090778
41regulation of neurotransmitter levels (GO:0001505)3.88232145
42potassium ion homeostasis (GO:0055075)3.84304295
43regulation of glutamate receptor signaling pathway (GO:1900449)3.83613717
44potassium ion import (GO:0010107)3.80795654
45regulation of excitatory postsynaptic membrane potential (GO:0060079)3.78594114
46membrane depolarization during action potential (GO:0086010)3.76939889
47regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.76356022
48regulation of neurotransmitter transport (GO:0051588)3.76227796
49regulation of synaptic plasticity (GO:0048167)3.75945818
50neuronal ion channel clustering (GO:0045161)3.72142627
51proline transport (GO:0015824)3.69126975
52negative regulation of dendrite morphogenesis (GO:0050774)3.68422557
53positive regulation of neurotransmitter secretion (GO:0001956)3.67357875
54cell communication by electrical coupling (GO:0010644)3.65703429
55positive regulation of membrane potential (GO:0045838)3.65151641
56postsynaptic membrane organization (GO:0001941)3.63507149
57neurotransmitter uptake (GO:0001504)3.59919945
58cerebellar Purkinje cell differentiation (GO:0021702)3.59515717
59neuron cell-cell adhesion (GO:0007158)3.59271307
60neurotransmitter-gated ion channel clustering (GO:0072578)3.58926452
61serotonin metabolic process (GO:0042428)3.57442150
62cellular sodium ion homeostasis (GO:0006883)3.54422896
63regulation of postsynaptic membrane potential (GO:0060078)3.53172893
64regulation of vesicle fusion (GO:0031338)3.51220597
65positive regulation of neurotransmitter transport (GO:0051590)3.50294960
66positive regulation of dendritic spine development (GO:0060999)3.43048560
67membrane depolarization (GO:0051899)3.36836234
68regulation of dendritic spine morphogenesis (GO:0061001)3.35794318
69vesicle docking involved in exocytosis (GO:0006904)3.35667910
70dendritic spine morphogenesis (GO:0060997)3.35029804
71transmission of nerve impulse (GO:0019226)3.34884888
72long-term synaptic potentiation (GO:0060291)3.32471351
73regulation of synapse structural plasticity (GO:0051823)3.32390940
74long-term memory (GO:0007616)3.29800884
75acidic amino acid transport (GO:0015800)3.29415829
76neuromuscular process controlling posture (GO:0050884)3.27191808
77regulation of dendritic spine development (GO:0060998)3.26964991
78detection of calcium ion (GO:0005513)3.26155126
79neuromuscular process controlling balance (GO:0050885)3.22792785
80positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.21401331
81synaptic transmission (GO:0007268)3.20414425
82regulation of synaptic transmission (GO:0050804)3.16687879
83primary amino compound metabolic process (GO:1901160)3.16496130
84vesicle docking (GO:0048278)3.16345708
85positive regulation of dendritic spine morphogenesis (GO:0061003)3.11367818
86regulation of synapse maturation (GO:0090128)3.10804611
87startle response (GO:0001964)3.09732042
88regulation of ARF protein signal transduction (GO:0032012)3.09205477
89establishment of synaptic vesicle localization (GO:0097480)3.09130004
90synaptic vesicle transport (GO:0048489)3.09130004
91cell communication involved in cardiac conduction (GO:0086065)3.03851107
92regulation of synaptic transmission, glutamatergic (GO:0051966)3.01508703
93presynaptic membrane organization (GO:0097090)2.99250261
94adult walking behavior (GO:0007628)2.98004994
95neuromuscular synaptic transmission (GO:0007274)2.96929805
96regulation of exocytosis (GO:0017157)2.95748553
97righting reflex (GO:0060013)2.95414145
98presynaptic membrane assembly (GO:0097105)2.93811909
99L-glutamate transport (GO:0015813)2.93779399
100potassium ion transmembrane transport (GO:0071805)2.91889460

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.37750097
2GBX2_23144817_ChIP-Seq_PC3_Human3.58511966
3REST_21632747_ChIP-Seq_MESCs_Mouse2.95186670
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.91164708
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.85147067
6DROSHA_22980978_ChIP-Seq_HELA_Human2.77773682
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.74725006
8RARB_27405468_Chip-Seq_BRAIN_Mouse2.52076819
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.47529263
10SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.35782798
11REST_18959480_ChIP-ChIP_MESCs_Mouse2.34884320
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.30508320
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.25017665
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.17225151
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.14210184
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.07871010
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.03278608
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.03278608
19SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.02006599
20RNF2_27304074_Chip-Seq_ESCs_Mouse1.92880243
21PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.90139551
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.89799058
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.89606743
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.88112514
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.84152560
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.81924270
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80900048
28AR_21572438_ChIP-Seq_LNCaP_Human1.80211071
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.79380235
30TAF15_26573619_Chip-Seq_HEK293_Human1.76432717
31SMAD4_21799915_ChIP-Seq_A2780_Human1.70926787
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.64554386
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.62573983
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.61219682
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60405878
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58044294
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53802499
38SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46344224
39RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.44354815
40NR3C1_23031785_ChIP-Seq_PC12_Mouse1.43812546
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.42951515
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.41955299
43OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38703883
44* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38129661
45* STAT3_23295773_ChIP-Seq_U87_Human1.36915440
46RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.35677295
47* TCF4_23295773_ChIP-Seq_U87_Human1.35073202
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34691263
49SOX2_21211035_ChIP-Seq_LN229_Gbm1.32672272
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32398254
51P300_19829295_ChIP-Seq_ESCs_Human1.30713208
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29614635
53* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26797496
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26494383
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.26185850
56TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.25426443
57* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24765426
58* AR_19668381_ChIP-Seq_PC3_Human1.24256697
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.23692314
60ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23607882
61WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22313547
62* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.18127009
63RNF2_27304074_Chip-Seq_NSC_Mouse1.14325439
64AR_25329375_ChIP-Seq_VCAP_Human1.13651998
65MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11128955
66TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09344176
67IGF1R_20145208_ChIP-Seq_DFB_Human1.08977514
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08929905
69NANOG_18555785_Chip-Seq_ESCs_Mouse1.05345410
70YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05254714
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05229468
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04515776
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04060660
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04060660
75TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03471288
76* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00396909
77VDR_22108803_ChIP-Seq_LS180_Human1.00132071
78PRDM14_20953172_ChIP-Seq_ESCs_Human0.99384594
79RING1B_27294783_Chip-Seq_ESCs_Mouse0.98542240
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98325865
81P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97257258
82LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97077847
83KDM2B_26808549_Chip-Seq_REH_Human0.96646944
84ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96232934
85SMAD4_21741376_ChIP-Seq_HESCs_Human0.95005833
86SMAD3_21741376_ChIP-Seq_HESCs_Human0.94518165
87NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93616068
88FLI1_21867929_ChIP-Seq_TH2_Mouse0.92572020
89* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92435199
90RUNX2_22187159_ChIP-Seq_PCA_Human0.92241241
91ARNT_22903824_ChIP-Seq_MCF-7_Human0.91454616
92FLI1_27457419_Chip-Seq_LIVER_Mouse0.90750428
93TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.90625915
94THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.90208226
95DNAJC2_21179169_ChIP-ChIP_NT2_Human0.89855003
96P53_22387025_ChIP-Seq_ESCs_Mouse0.89604269
97E2F1_18555785_Chip-Seq_ESCs_Mouse0.89294844
98EP300_21415370_ChIP-Seq_HL-1_Mouse0.86775671
99CMYC_18555785_Chip-Seq_ESCs_Mouse0.86761485
100* TP53_16413492_ChIP-PET_HCT116_Human0.86481414

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.41631745
2MP0003880_abnormal_central_pattern5.48991467
3MP0004270_analgesia4.33273804
4MP0003635_abnormal_synaptic_transmissio4.06878052
5MP0002064_seizures3.85754340
6MP0009046_muscle_twitch3.79547042
7MP0009745_abnormal_behavioral_response3.53786480
8MP0005423_abnormal_somatic_nervous3.36468076
9MP0002272_abnormal_nervous_system3.24794608
10MP0002063_abnormal_learning/memory/cond3.20087187
11MP0001486_abnormal_startle_reflex3.18402509
12MP0001968_abnormal_touch/_nociception3.12480337
13MP0001501_abnormal_sleep_pattern2.96890989
14MP0002572_abnormal_emotion/affect_behav2.76194907
15MP0002734_abnormal_mechanical_nocicepti2.68200790
16MP0008569_lethality_at_weaning2.54781401
17MP0002736_abnormal_nociception_after2.35210189
18MP0003879_abnormal_hair_cell2.34190209
19MP0002735_abnormal_chemical_nociception2.10164370
20MP0009780_abnormal_chondrocyte_physiolo1.99293765
21MP0001970_abnormal_pain_threshold1.98615421
22MP0002733_abnormal_thermal_nociception1.97321493
23MP0005646_abnormal_pituitary_gland1.94095875
24MP0002067_abnormal_sensory_capabilities1.90798414
25MP0003787_abnormal_imprinting1.85078372
26MP0003329_amyloid_beta_deposits1.76876596
27MP0000920_abnormal_myelination1.76669236
28MP0003690_abnormal_glial_cell1.74216424
29MP0003633_abnormal_nervous_system1.71912456
30MP0001440_abnormal_grooming_behavior1.66542630
31MP0005386_behavior/neurological_phenoty1.60054851
32MP0004924_abnormal_behavior1.60054851
33MP0004811_abnormal_neuron_physiology1.59699415
34MP0002557_abnormal_social/conspecific_i1.55601365
35MP0006276_abnormal_autonomic_nervous1.53305947
36MP0004885_abnormal_endolymph1.51849447
37MP0001984_abnormal_olfaction1.48484908
38MP0002066_abnormal_motor_capabilities/c1.47804070
39MP0000778_abnormal_nervous_system1.42624364
40MP0001905_abnormal_dopamine_level1.40956383
41MP0003631_nervous_system_phenotype1.40745029
42MP0002882_abnormal_neuron_morphology1.37833505
43MP0001502_abnormal_circadian_rhythm1.30589082
44MP0005551_abnormal_eye_electrophysiolog1.28331427
45MP0002229_neurodegeneration1.26901582
46MP0000955_abnormal_spinal_cord1.26588866
47MP0001177_atelectasis1.25718627
48MP0004742_abnormal_vestibular_system1.23244795
49MP0010386_abnormal_urinary_bladder1.18747251
50MP0004147_increased_porphyrin_level1.17833663
51MP0002184_abnormal_innervation1.15957490
52MP0008872_abnormal_physiological_respon1.09735796
53MP0008877_abnormal_DNA_methylation1.07638912
54MP0000569_abnormal_digit_pigmentation1.05071638
55MP0001485_abnormal_pinna_reflex1.01954671
56MP0001963_abnormal_hearing_physiology0.99352532
57MP0003122_maternal_imprinting0.98975933
58MP0008874_decreased_physiological_sensi0.98273687
59MP0002638_abnormal_pupillary_reflex0.98005349
60MP0002152_abnormal_brain_morphology0.95647291
61MP0003632_abnormal_nervous_system0.95329520
62MP0003634_abnormal_glial_cell0.94314846
63MP0002822_catalepsy0.92388373
64MP0004142_abnormal_muscle_tone0.88516106
65MP0005167_abnormal_blood-brain_barrier0.86524852
66MP0000579_abnormal_nail_morphology0.85754157
67MP0001986_abnormal_taste_sensitivity0.81511123
68MP0005645_abnormal_hypothalamus_physiol0.80602386
69MP0001529_abnormal_vocalization0.73756036
70MP0001348_abnormal_lacrimal_gland0.72780434
71MP0002069_abnormal_eating/drinking_beha0.70905056
72MP0003045_fibrosis0.70836803
73MP0004043_abnormal_pH_regulation0.68335492
74MP0005535_abnormal_body_temperature0.67919224
75MP0003123_paternal_imprinting0.67449385
76MP0000604_amyloidosis0.66790296
77MP0002909_abnormal_adrenal_gland0.66762681
78MP0002752_abnormal_somatic_nervous0.66671007
79MP0003075_altered_response_to0.66208353
80MP0005623_abnormal_meninges_morphology0.65451314
81MP0004215_abnormal_myocardial_fiber0.64655544
82MP0002090_abnormal_vision0.61913262
83MP0004130_abnormal_muscle_cell0.59725825
84MP0004085_abnormal_heartbeat0.59420491
85MP0010769_abnormal_survival0.53495726
86MP0004510_myositis0.53226818
87MP0003137_abnormal_impulse_conducting0.52619037
88MP0001346_abnormal_lacrimal_gland0.52306040
89MP0001765_abnormal_ion_homeostasis0.51167238
90MP0002876_abnormal_thyroid_physiology0.50556197
91MP0010768_mortality/aging0.50285035
92MP0001299_abnormal_eye_distance/0.49441709
93MP0002082_postnatal_lethality0.48800148
94MP0010770_preweaning_lethality0.48800148
95MP0003172_abnormal_lysosome_physiology0.46742624
96MP0004484_altered_response_of0.46725697
97MP0003956_abnormal_body_size0.46429209
98MP0005253_abnormal_eye_physiology0.44202245
99MP0000026_abnormal_inner_ear0.42820285
100MP0001943_abnormal_respiration0.41942955

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.33717234
2Myokymia (HP:0002411)7.25954962
3Focal seizures (HP:0007359)6.73866760
4Febrile seizures (HP:0002373)6.69324128
5Atonic seizures (HP:0010819)6.30023267
6Epileptic encephalopathy (HP:0200134)5.65677456
7Action tremor (HP:0002345)5.34652719
8Abnormality of binocular vision (HP:0011514)5.16772426
9Diplopia (HP:0000651)5.16772426
10Supranuclear gaze palsy (HP:0000605)4.60841303
11Absence seizures (HP:0002121)4.59453751
12Generalized tonic-clonic seizures (HP:0002069)4.53021142
13Dialeptic seizures (HP:0011146)4.51060051
14Progressive cerebellar ataxia (HP:0002073)4.29711557
15Ankle clonus (HP:0011448)4.04772883
16Spastic gait (HP:0002064)3.85059564
17Postural instability (HP:0002172)3.79252701
18Visual hallucinations (HP:0002367)3.77623925
19Cerebral hypomyelination (HP:0006808)3.54793931
20Papilledema (HP:0001085)3.53860949
21Abnormal eating behavior (HP:0100738)3.45761629
22Urinary bladder sphincter dysfunction (HP:0002839)3.42513739
23Gaze-evoked nystagmus (HP:0000640)3.42011007
24Truncal ataxia (HP:0002078)3.41923181
25Neurofibrillary tangles (HP:0002185)3.40073057
26Limb dystonia (HP:0002451)3.27941075
27Dysmetria (HP:0001310)3.27321100
28Epileptiform EEG discharges (HP:0011182)3.19893250
29Hemiplegia (HP:0002301)3.18786577
30Hyperventilation (HP:0002883)3.18653080
31Torticollis (HP:0000473)3.14595524
32Status epilepticus (HP:0002133)3.14292531
33Intention tremor (HP:0002080)3.09812964
34Hemiparesis (HP:0001269)3.03878117
35Impaired vibration sensation in the lower limbs (HP:0002166)3.03011807
36Mutism (HP:0002300)3.02826531
37Delusions (HP:0000746)3.02283121
38Poor eye contact (HP:0000817)2.97861053
39Tetraplegia (HP:0002445)2.95589114
40Lower limb muscle weakness (HP:0007340)2.91597300
41Abnormality of the corticospinal tract (HP:0002492)2.86263328
42Bradykinesia (HP:0002067)2.77923759
43EEG with generalized epileptiform discharges (HP:0011198)2.77312734
44Scanning speech (HP:0002168)2.76875990
45Impaired smooth pursuit (HP:0007772)2.72812312
46Cerebral inclusion bodies (HP:0100314)2.71391351
47Urinary urgency (HP:0000012)2.68362405
48Anxiety (HP:0000739)2.67584150
49Clonus (HP:0002169)2.65910241
50Dysdiadochokinesis (HP:0002075)2.58546774
51Focal dystonia (HP:0004373)2.57583404
52Obstructive sleep apnea (HP:0002870)2.57242279
53Hypsarrhythmia (HP:0002521)2.54862062
54Broad-based gait (HP:0002136)2.53311175
55Annular pancreas (HP:0001734)2.53277074
56Depression (HP:0000716)2.52690194
57Amblyopia (HP:0000646)2.49832666
58Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.49420777
59Degeneration of the lateral corticospinal tracts (HP:0002314)2.49420777
60Abnormality of ocular smooth pursuit (HP:0000617)2.49377214
61Impaired vibratory sensation (HP:0002495)2.46702383
62Neuronal loss in central nervous system (HP:0002529)2.43387718
63Akinesia (HP:0002304)2.40857122
64Absent speech (HP:0001344)2.38316839
65Craniofacial dystonia (HP:0012179)2.37179263
66Abnormality of the lower motor neuron (HP:0002366)2.35898734
67Abnormal social behavior (HP:0012433)2.33843396
68Impaired social interactions (HP:0000735)2.33843396
69Dysmetric saccades (HP:0000641)2.27201060
70CNS hypomyelination (HP:0003429)2.26739317
71Genetic anticipation (HP:0003743)2.22710045
72Rigidity (HP:0002063)2.22345194
73Drooling (HP:0002307)2.21906668
74Increased circulating renin level (HP:0000848)2.15360081
75Bundle branch block (HP:0011710)2.14683149
76Spastic tetraparesis (HP:0001285)2.13747501
77Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.12839531
78Polyphagia (HP:0002591)2.09660406
79Choreoathetosis (HP:0001266)2.05898807
80Morphological abnormality of the pyramidal tract (HP:0002062)2.05134156
81Peripheral hypomyelination (HP:0007182)2.03036445
82Apathy (HP:0000741)2.02002899
83Excessive salivation (HP:0003781)2.01903185
84Sleep apnea (HP:0010535)1.99943817
85Abnormality of saccadic eye movements (HP:0000570)1.96598014
86Incomplete penetrance (HP:0003829)1.94246693
87Stereotypic behavior (HP:0000733)1.88424350
88Megalencephaly (HP:0001355)1.85514421
89Ventricular fibrillation (HP:0001663)1.84864510
90Rapidly progressive (HP:0003678)1.84572428
91Split foot (HP:0001839)1.84557201
92Amyotrophic lateral sclerosis (HP:0007354)1.84007378
93Hypokalemic alkalosis (HP:0001949)1.83741879
94Inability to walk (HP:0002540)1.76895056
95Generalized myoclonic seizures (HP:0002123)1.75759124
96Gait ataxia (HP:0002066)1.75304607
97Diminished motivation (HP:0000745)1.74679032
98Spastic paraplegia (HP:0001258)1.69773970
99Paraplegia (HP:0010550)1.69496608
100Heart block (HP:0012722)1.67867142

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.60540806
2NTRK34.36599597
3DAPK23.73460736
4PAK63.71348093
5MARK13.27330873
6MAP3K92.68262111
7NTRK22.48998091
8UHMK12.41772110
9MINK12.21183533
10CASK2.08496468
11PLK22.03912030
12CAMKK12.03224850
13GRK52.03061937
14PRKD31.96355370
15NTRK11.91632738
16FRK1.83987700
17LATS21.80149881
18DAPK11.67921588
19MAPK131.66821262
20CDK51.58003346
21PINK11.53039527
22CAMK11.50142292
23PRKCG1.41078644
24CAMKK21.39628559
25RIPK41.38133743
26CAMK2B1.37806598
27PAK31.37118574
28ARAF1.31779270
29MAP3K41.30177471
30PHKG21.21414565
31PHKG11.21414565
32STK381.17380618
33CAMK2A1.16648535
34OXSR11.16637519
35SGK4941.11902650
36SGK2231.11902650
37PRKCH1.09780618
38KSR21.09451257
39SIK21.07401271
40NEK61.02959302
41BMPR21.02536242
42SGK20.98807723
43CDK180.97873719
44CDK150.97657235
45TYRO30.97211134
46CDK190.96656058
47DYRK1A0.92105015
48CDK140.87021016
49CDK11A0.85676140
50CAMK2G0.84760806
51PKN10.83715497
52MAP3K120.82497890
53CCNB10.79340342
54SGK30.78389792
55PTK2B0.77243750
56STK110.76030335
57PDK10.75519091
58SGK10.72677828
59RIPK10.69689748
60MAP2K70.69687410
61MAPK120.67798716
62LMTK20.66484992
63MAPK100.65880318
64STK390.63722400
65PRKCE0.63632641
66CAMK40.61402588
67MAP3K20.61122462
68MAP3K130.60228572
69CAMK2D0.59438384
70MARK20.58681664
71WNK10.58123345
72CSNK1G20.57270252
73LIMK10.57063749
74RPS6KA30.55499713
75MAP2K40.53732609
76BRSK10.52636142
77FGFR20.51606477
78PDPK10.51049165
79PNCK0.50285918
80ALK0.48454325
81MAPKAPK50.47822127
82KSR10.47562370
83ROCK20.46503801
84RAF10.45309068
85CAMK1G0.44647723
86MAP2K10.43699024
87DAPK30.42767364
88AKT30.42065426
89PRKCA0.41371726
90FYN0.39862048
91TNK20.37748079
92PRPF4B0.37282546
93PRKCZ0.36778712
94PRKG10.35753844
95MOS0.34214525
96ROCK10.33622302
97BRAF0.33492187
98PRKCB0.33406875
99ADRBK20.33247717
100CSNK1D0.32046774

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.36111176
2Synaptic vesicle cycle_Homo sapiens_hsa047213.91257263
3GABAergic synapse_Homo sapiens_hsa047272.91304966
4Circadian entrainment_Homo sapiens_hsa047132.82440341
5Long-term potentiation_Homo sapiens_hsa047202.80070798
6Morphine addiction_Homo sapiens_hsa050322.79837669
7Amphetamine addiction_Homo sapiens_hsa050312.73973137
8Glutamatergic synapse_Homo sapiens_hsa047242.68424117
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.64477794
10Insulin secretion_Homo sapiens_hsa049112.50852698
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.26450454
12Dopaminergic synapse_Homo sapiens_hsa047282.17537662
13Gastric acid secretion_Homo sapiens_hsa049712.15315609
14Salivary secretion_Homo sapiens_hsa049702.13173084
15Cocaine addiction_Homo sapiens_hsa050301.95892097
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.82913602
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.81954953
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.73491078
19Cholinergic synapse_Homo sapiens_hsa047251.72703967
20Taste transduction_Homo sapiens_hsa047421.71632416
21Calcium signaling pathway_Homo sapiens_hsa040201.67254306
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.65192895
23Renin secretion_Homo sapiens_hsa049241.61781257
24Oxytocin signaling pathway_Homo sapiens_hsa049211.61005055
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.50675360
26cAMP signaling pathway_Homo sapiens_hsa040241.46675140
27Long-term depression_Homo sapiens_hsa047301.40827465
28Olfactory transduction_Homo sapiens_hsa047401.39417183
29Serotonergic synapse_Homo sapiens_hsa047261.38276157
30Collecting duct acid secretion_Homo sapiens_hsa049661.34322317
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.33004815
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.31162488
33Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.30499066
34Phototransduction_Homo sapiens_hsa047441.25425892
35Pancreatic secretion_Homo sapiens_hsa049721.17758815
36cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12826889
37Estrogen signaling pathway_Homo sapiens_hsa049151.10225052
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09012594
39GnRH signaling pathway_Homo sapiens_hsa049121.08417695
40Glioma_Homo sapiens_hsa052141.07131087
41Gap junction_Homo sapiens_hsa045401.05556138
42Vitamin B6 metabolism_Homo sapiens_hsa007501.03570936
43Vascular smooth muscle contraction_Homo sapiens_hsa042700.93240249
44Oocyte meiosis_Homo sapiens_hsa041140.92735427
45Circadian rhythm_Homo sapiens_hsa047100.86758813
46Vibrio cholerae infection_Homo sapiens_hsa051100.86331397
47Phospholipase D signaling pathway_Homo sapiens_hsa040720.84893344
48Bile secretion_Homo sapiens_hsa049760.83904782
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83877058
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83405380
51Thyroid hormone synthesis_Homo sapiens_hsa049180.82909519
52Melanogenesis_Homo sapiens_hsa049160.82078064
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80749974
54Type II diabetes mellitus_Homo sapiens_hsa049300.78774347
55ErbB signaling pathway_Homo sapiens_hsa040120.77674397
56Dorso-ventral axis formation_Homo sapiens_hsa043200.73098775
57Inositol phosphate metabolism_Homo sapiens_hsa005620.70135978
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70098431
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68532401
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68353096
61Ras signaling pathway_Homo sapiens_hsa040140.67876891
62Axon guidance_Homo sapiens_hsa043600.62180962
63Cardiac muscle contraction_Homo sapiens_hsa042600.62110894
64Rap1 signaling pathway_Homo sapiens_hsa040150.60746161
65Glucagon signaling pathway_Homo sapiens_hsa049220.58307306
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57920965
67MAPK signaling pathway_Homo sapiens_hsa040100.56709937
68Nitrogen metabolism_Homo sapiens_hsa009100.54552107
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.52417559
70Dilated cardiomyopathy_Homo sapiens_hsa054140.52067350
71Histidine metabolism_Homo sapiens_hsa003400.49885924
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.49383396
73Endocytosis_Homo sapiens_hsa041440.47143799
74Mineral absorption_Homo sapiens_hsa049780.46900740
75Choline metabolism in cancer_Homo sapiens_hsa052310.46672724
76beta-Alanine metabolism_Homo sapiens_hsa004100.46505485
77VEGF signaling pathway_Homo sapiens_hsa043700.46476356
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45827998
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44781801
80Fatty acid biosynthesis_Homo sapiens_hsa000610.40517647
81Alcoholism_Homo sapiens_hsa050340.37397268
82Platelet activation_Homo sapiens_hsa046110.35942226
83Arginine and proline metabolism_Homo sapiens_hsa003300.35614085
84ABC transporters_Homo sapiens_hsa020100.34875985
85Ovarian steroidogenesis_Homo sapiens_hsa049130.34036994
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33319398
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33308757
88Regulation of autophagy_Homo sapiens_hsa041400.32934481
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32607212
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30821732
91Prion diseases_Homo sapiens_hsa050200.28054970
92Butanoate metabolism_Homo sapiens_hsa006500.27049660
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25796781
94Sphingolipid metabolism_Homo sapiens_hsa006000.23094500
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22571097
96Ether lipid metabolism_Homo sapiens_hsa005650.22082983
97Tight junction_Homo sapiens_hsa045300.21594284
98Wnt signaling pathway_Homo sapiens_hsa043100.21200555
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.17683952
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.17013213

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