ZNF366

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1virion attachment to host cell (GO:0019062)5.66850830
2adhesion of symbiont to host cell (GO:0044650)5.66850830
3cellular extravasation (GO:0045123)5.54188449
4adhesion of symbiont to host (GO:0044406)4.61808386
5positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.43462305
6positive regulation of mast cell activation (GO:0033005)4.37307264
7activated T cell proliferation (GO:0050798)4.14782761
8regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.10800485
9negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.77035643
10positive regulation of gamma-delta T cell activation (GO:0046645)3.75455110
11positive regulation of mast cell degranulation (GO:0043306)3.69000987
12positive regulation of mast cell activation involved in immune response (GO:0033008)3.69000987
13regulation of mast cell activation (GO:0033003)3.46625601
14regulation of memory T cell differentiation (GO:0043380)3.36303695
15platelet dense granule organization (GO:0060155)3.35378358
16positive regulation of antigen processing and presentation (GO:0002579)3.32950803
17regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.30716414
18regulation of hypersensitivity (GO:0002883)3.29944178
19eosinophil chemotaxis (GO:0048245)3.23018982
20tryptophan catabolic process (GO:0006569)3.20944500
21indole-containing compound catabolic process (GO:0042436)3.20944500
22indolalkylamine catabolic process (GO:0046218)3.20944500
23glycosphingolipid catabolic process (GO:0046479)3.17919969
24kynurenine metabolic process (GO:0070189)3.16013931
25wound healing, spreading of epidermal cells (GO:0035313)3.05880799
26positive regulation of B cell differentiation (GO:0045579)2.98768986
27neutrophil activation involved in immune response (GO:0002283)2.95386200
28superoxide anion generation (GO:0042554)2.92025612
29ceramide catabolic process (GO:0046514)2.89824350
30T-helper 1 type immune response (GO:0042088)2.88146789
31immunoglobulin mediated immune response (GO:0016064)2.87552693
32eosinophil migration (GO:0072677)2.87162516
33behavioral response to nicotine (GO:0035095)2.86266786
34leukocyte migration involved in inflammatory response (GO:0002523)2.85915766
35regulation of cholesterol storage (GO:0010885)2.85644905
36regulation of sequestering of triglyceride (GO:0010889)2.85462518
37regulation of inflammatory response to antigenic stimulus (GO:0002861)2.83276776
38glycolipid catabolic process (GO:0019377)2.82151287
39positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.80952781
40response to xenobiotic stimulus (GO:0009410)2.70337273
41regulation of antigen processing and presentation (GO:0002577)2.70170977
42intracellular pH reduction (GO:0051452)2.68557196
43negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.65821541
44regulation of gamma-delta T cell activation (GO:0046643)2.64741897
45positive regulation of bone resorption (GO:0045780)2.62256656
46positive regulation of bone remodeling (GO:0046852)2.62256656
47positive regulation of T-helper 1 type immune response (GO:0002827)2.59953518
48positive regulation of defense response to virus by host (GO:0002230)2.56333281
49negative regulation of mast cell activation (GO:0033004)2.56291284
50cellular biogenic amine catabolic process (GO:0042402)2.55166906
51amine catabolic process (GO:0009310)2.55166906
52tryptophan metabolic process (GO:0006568)2.54933214
53negative regulation of interleukin-17 production (GO:0032700)2.54653716
54positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.53312391
55lipoxygenase pathway (GO:0019372)2.52514402
56regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.52293736
57positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.51630472
58regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.50663662
59negative regulation of interleukin-1 beta production (GO:0032691)2.50207447
60phagosome maturation (GO:0090382)2.49332573
61cellular response to ethanol (GO:0071361)2.47955487
62positive regulation of T-helper cell differentiation (GO:0045624)2.46594594
63L-fucose catabolic process (GO:0042355)2.46162830
64fucose catabolic process (GO:0019317)2.46162830
65L-fucose metabolic process (GO:0042354)2.46162830
66positive regulation of osteoclast differentiation (GO:0045672)2.45889616
67regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.43546930
68negative regulation of interleukin-12 production (GO:0032695)2.43152900
69indolalkylamine metabolic process (GO:0006586)2.43110391
70positive regulation of tissue remodeling (GO:0034105)2.41961226
71positive regulation of prostaglandin secretion (GO:0032308)2.38509451
72regulation of gamma-delta T cell differentiation (GO:0045586)2.38240837
73negative regulation of adaptive immune response (GO:0002820)2.35907159
74regulation of macrophage derived foam cell differentiation (GO:0010743)2.35845950
75cellular response to exogenous dsRNA (GO:0071360)2.35382180
76regulation of T-helper 1 type immune response (GO:0002825)2.33381948
77pH reduction (GO:0045851)2.33134557
78regulation of vitamin D biosynthetic process (GO:0060556)2.31899515
79positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.31262592
80regulation of T-helper cell differentiation (GO:0045622)2.30798381
81positive regulation of calcium-mediated signaling (GO:0050850)2.30789291
82energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.30082181
83ATP hydrolysis coupled proton transport (GO:0015991)2.30082181
84macrophage activation involved in immune response (GO:0002281)2.29159022
85negative regulation of macrophage differentiation (GO:0045650)2.28429734
86signal peptide processing (GO:0006465)2.28169515
87response to lipoprotein particle (GO:0055094)2.27924862
88long-chain fatty acid biosynthetic process (GO:0042759)2.27888426
89granulocyte chemotaxis (GO:0071621)2.27651316
90oligosaccharide catabolic process (GO:0009313)2.27627682
91negative regulation of interleukin-1 production (GO:0032692)2.27155198
92positive regulation of type 2 immune response (GO:0002830)2.25505710
93regulation of mast cell degranulation (GO:0043304)2.25326615
94regulation of activation of Janus kinase activity (GO:0010533)2.24698508
95positive regulation of leukocyte degranulation (GO:0043302)2.24051388
96regulation of interleukin-6 biosynthetic process (GO:0045408)2.23326493
97DNA deamination (GO:0045006)2.23151941
98dendritic cell chemotaxis (GO:0002407)2.23091216
99regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.22260890
100granulocyte activation (GO:0036230)2.21999452

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.32623088
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.68022280
3IRF8_27001747_Chip-Seq_BMDM_Mouse2.70762642
4IRF8_21731497_ChIP-ChIP_J774_Mouse2.69452394
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.46051865
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.36306852
7VDR_22108803_ChIP-Seq_LS180_Human2.28209161
8EZH2_22144423_ChIP-Seq_EOC_Human2.20829338
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.00924837
10LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.86333485
11ZNF274_21170338_ChIP-Seq_K562_Hela1.79420170
12* VDR_24787735_ChIP-Seq_THP-1_Human1.77533549
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.72750370
14SCL_19346495_ChIP-Seq_HPC-7_Human1.67660079
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56932014
16PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.55664188
17IKZF1_21737484_ChIP-ChIP_HCT116_Human1.54262144
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.47769359
19ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41971575
20PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.41221347
21* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35823248
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.35243126
23EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.34389762
24RUNX_20019798_ChIP-Seq_JUKART_Human1.34370016
25GATA3_21878914_ChIP-Seq_MCF-7_Human1.31647944
26ETV2_25802403_ChIP-Seq_MESCs_Mouse1.29961746
27LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.29439677
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28293365
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.26338346
30GBX2_23144817_ChIP-Seq_PC3_Human1.22456974
31IGF1R_20145208_ChIP-Seq_DFB_Human1.22067224
32RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20166437
33BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18185489
34GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17227063
35GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.15717238
36PRDM14_20953172_ChIP-Seq_ESCs_Human1.15425485
37PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.15160818
38SOX2_19829295_ChIP-Seq_ESCs_Human1.13522756
39NANOG_19829295_ChIP-Seq_ESCs_Human1.13522756
40GATA3_26560356_Chip-Seq_TH2_Human1.12238343
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10934006
42IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.09820749
43TP53_22573176_ChIP-Seq_HFKS_Human1.08381285
44P300_19829295_ChIP-Seq_ESCs_Human1.08372351
45SMRT_27268052_Chip-Seq_Bcells_Human1.07730994
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06712303
47BCAT_22108803_ChIP-Seq_LS180_Human1.06359305
48CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.06155470
49ER_23166858_ChIP-Seq_MCF-7_Human1.05438677
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05205214
51REST_21632747_ChIP-Seq_MESCs_Mouse1.04513625
52SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03788812
53* SPI1_23127762_ChIP-Seq_K562_Human1.03349909
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.01872423
55TP53_16413492_ChIP-PET_HCT116_Human1.00937854
56FOXH1_21741376_ChIP-Seq_ESCs_Human1.00258864
57TAF2_19829295_ChIP-Seq_ESCs_Human0.99569721
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99028707
59POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99028707
60MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.98629294
61GATA3_27048872_Chip-Seq_THYMUS_Human0.97718479
62NCOR_22424771_ChIP-Seq_293T_Human0.96504995
63FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96285091
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96172439
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95289679
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94848478
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94605653
68CDX2_22108803_ChIP-Seq_LS180_Human0.94500967
69MYC_19829295_ChIP-Seq_ESCs_Human0.93083472
70PCGF2_27294783_Chip-Seq_ESCs_Mouse0.92869070
71RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.92091681
72AR_25329375_ChIP-Seq_VCAP_Human0.91362282
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91048711
74POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90475003
75GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90269360
76SMAD4_21741376_ChIP-Seq_EPCs_Human0.89136329
77JARID2_20064375_ChIP-Seq_MESCs_Mouse0.88968304
78NANOG_20526341_ChIP-Seq_ESCs_Human0.87148060
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87099228
80IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.86455167
81CBP_20019798_ChIP-Seq_JUKART_Human0.86455167
82FOXH1_21741376_ChIP-Seq_EPCs_Human0.85865973
83TCF4_22108803_ChIP-Seq_LS180_Human0.85122064
84FLI1_21867929_ChIP-Seq_TH2_Mouse0.84645242
85NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.84057109
86TCF4_23295773_ChIP-Seq_U87_Human0.83305246
87EZH2_27294783_Chip-Seq_NPCs_Mouse0.83298152
88* STAT3_23295773_ChIP-Seq_U87_Human0.83272888
89NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82852328
90SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.82846801
91EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.82686591
92SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82428577
93STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.82306815
94* SPI1_23547873_ChIP-Seq_NB4_Human0.82280529
95GATA1_19941826_ChIP-Seq_K562_Human0.82256507
96SUZ12_27294783_Chip-Seq_NPCs_Mouse0.82206424
97OCT1_27270436_Chip-Seq_PROSTATE_Human0.81637002
98SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.81633652
99KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.81172442
100TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.80863709

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.26905438
2MP0003724_increased_susceptibility_to3.19280540
3MP0002148_abnormal_hypersensitivity_rea2.84227354
4MP0005670_abnormal_white_adipose2.73682635
5MP0005167_abnormal_blood-brain_barrier2.70770740
6MP0003195_calcinosis2.44175480
7MP0003646_muscle_fatigue2.34909305
8MP0001835_abnormal_antigen_presentation2.34301597
9MP0000343_altered_response_to2.21879657
10MP0002837_dystrophic_cardiac_calcinosis2.20628791
11MP0005387_immune_system_phenotype2.12756559
12MP0001790_abnormal_immune_system2.12756559
13MP0003172_abnormal_lysosome_physiology2.07691788
14MP0000569_abnormal_digit_pigmentation2.06008974
15MP0002419_abnormal_innate_immunity2.04343922
16MP0003303_peritoneal_inflammation1.96553553
17MP0004147_increased_porphyrin_level1.94205183
18MP0006082_CNS_inflammation1.92932799
19MP0008004_abnormal_stomach_pH1.88338844
20MP0002138_abnormal_hepatobiliary_system1.85887742
21MP0001986_abnormal_taste_sensitivity1.85854674
22MP0004130_abnormal_muscle_cell1.71133191
23MP0005058_abnormal_lysosome_morphology1.70953993
24MP0009785_altered_susceptibility_to1.67544070
25MP0005025_abnormal_response_to1.66336212
26MP0002452_abnormal_antigen_presenting1.65650982
27MP0009764_decreased_sensitivity_to1.63451222
28MP0005647_abnormal_sex_gland1.63042727
29MP0003011_delayed_dark_adaptation1.58330897
30MP0004084_abnormal_cardiac_muscle1.58059481
31MP0005000_abnormal_immune_tolerance1.55896344
32MP0008875_abnormal_xenobiotic_pharmacok1.49302231
33MP0002723_abnormal_immune_serum1.46682313
34MP0005646_abnormal_pituitary_gland1.45268331
35MP0003075_altered_response_to1.44649521
36MP0002102_abnormal_ear_morphology1.43865235
37MP0004885_abnormal_endolymph1.43452990
38MP0001800_abnormal_humoral_immune1.40967048
39MP0005464_abnormal_platelet_physiology1.39495061
40MP0000685_abnormal_immune_system1.37711544
41MP0000015_abnormal_ear_pigmentation1.34580520
42MP0009115_abnormal_fat_cell1.34207056
43MP0005365_abnormal_bile_salt1.29494328
44MP0005174_abnormal_tail_pigmentation1.28345624
45MP0001819_abnormal_immune_cell1.28261064
46MP0002420_abnormal_adaptive_immunity1.26479398
47MP0001958_emphysema1.25928574
48MP0002405_respiratory_system_inflammati1.20440353
49MP0000604_amyloidosis1.20107664
50MP0009046_muscle_twitch1.19819243
51MP0003436_decreased_susceptibility_to1.19547479
52MP0005310_abnormal_salivary_gland1.18076251
53MP0004742_abnormal_vestibular_system1.17683230
54MP0003828_pulmonary_edema1.17591832
55MP0002971_abnormal_brown_adipose1.16156644
56MP0005166_decreased_susceptibility_to1.14200529
57MP0001845_abnormal_inflammatory_respons1.13392293
58MP0002332_abnormal_exercise_endurance1.12692008
59MP0001533_abnormal_skeleton_physiology1.11634505
60MP0005551_abnormal_eye_electrophysiolog1.07820027
61MP0000371_diluted_coat_color1.06532454
62MP0004036_abnormal_muscle_relaxation1.05637467
63MP0003279_aneurysm1.04031116
64MP0001764_abnormal_homeostasis1.03457452
65MP0000230_abnormal_systemic_arterial1.01832897
66MP0001727_abnormal_embryo_implantation1.01679301
67MP0008469_abnormal_protein_level1.00068397
68MP0004215_abnormal_myocardial_fiber1.00063650
69MP0005595_abnormal_vascular_smooth0.99920112
70MP0004484_altered_response_of0.98113276
71MP0005253_abnormal_eye_physiology0.97842597
72MP0005379_endocrine/exocrine_gland_phen0.96799761
73MP0001545_abnormal_hematopoietic_system0.94966699
74MP0005397_hematopoietic_system_phenotyp0.94966699
75MP0005410_abnormal_fertilization0.93814408
76MP0000249_abnormal_blood_vessel0.92027857
77MP0002163_abnormal_gland_morphology0.91371156
78MP0001853_heart_inflammation0.90442421
79MP0010329_abnormal_lipoprotein_level0.88680855
80MP0004142_abnormal_muscle_tone0.86178749
81MP0001968_abnormal_touch/_nociception0.85361723
82MP0003879_abnormal_hair_cell0.84950117
83MP0002638_abnormal_pupillary_reflex0.83079120
84MP0004043_abnormal_pH_regulation0.83041658
85MP0001486_abnormal_startle_reflex0.82397780
86MP0009840_abnormal_foam_cell0.82378819
87MP0003183_abnormal_peptide_metabolism0.80126759
88MP0003638_abnormal_response/metabolism_0.78540727
89MP0000716_abnormal_immune_system0.78156435
90MP0001485_abnormal_pinna_reflex0.78056300
91MP0005084_abnormal_gallbladder_morpholo0.77359809
92MP0003806_abnormal_nucleotide_metabolis0.76245047
93MP0005377_hearing/vestibular/ear_phenot0.74831924
94MP0003878_abnormal_ear_physiology0.74831924
95MP0009765_abnormal_xenobiotic_induced0.74312248
96MP0004145_abnormal_muscle_electrophysio0.74189651
97MP0009745_abnormal_behavioral_response0.74188525
98MP0002998_abnormal_bone_remodeling0.74117371
99MP0002733_abnormal_thermal_nociception0.73985660
100MP0002693_abnormal_pancreas_physiology0.73473498

Predicted human phenotypes

RankGene SetZ-score
1Vacuolated lymphocytes (HP:0001922)7.81426595
2Abnormality of liposaccharide metabolism (HP:0010968)4.43772467
3Abnormality of glycosphingolipid metabolism (HP:0004343)4.43772467
4Abnormality of glycolipid metabolism (HP:0010969)4.43772467
5Systemic lupus erythematosus (HP:0002725)3.75887852
6Esophageal varix (HP:0002040)3.66186694
7Abnormality of macrophages (HP:0004311)3.57692516
8Increased cerebral lipofuscin (HP:0011813)3.21520395
9Recurrent bacterial skin infections (HP:0005406)3.20974875
10Congenital sensorineural hearing impairment (HP:0008527)3.19573383
11Congenital stationary night blindness (HP:0007642)3.18776351
12Recurrent cutaneous fungal infections (HP:0011370)3.15499911
13Chronic mucocutaneous candidiasis (HP:0002728)3.15499911
14Protuberant abdomen (HP:0001538)3.06838294
15Increased neuronal autofluorescent lipopigment (HP:0002074)3.02286596
16Absent rod-and cone-mediated responses on ERG (HP:0007688)3.01787578
17Generalized aminoaciduria (HP:0002909)2.95743944
18Decreased electroretinogram (ERG) amplitude (HP:0000654)2.92405167
19Abnormal rod and cone electroretinograms (HP:0008323)2.92223278
20Abolished electroretinogram (ERG) (HP:0000550)2.86763581
21Hematochezia (HP:0002573)2.86215682
22Recurrent abscess formation (HP:0002722)2.82564440
23Agitation (HP:0000713)2.77695161
24Congenital hepatic fibrosis (HP:0002612)2.74711183
25Mutism (HP:0002300)2.72706965
26Spontaneous hematomas (HP:0007420)2.71979757
27Adactyly (HP:0009776)2.67905046
28Hemoptysis (HP:0002105)2.54772205
29Dysostosis multiplex (HP:0000943)2.50838557
30Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.48969743
31Recurrent skin infections (HP:0001581)2.41998647
32Abnormality of alanine metabolism (HP:0010916)2.37407239
33Hyperalaninemia (HP:0003348)2.37407239
34Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.37407239
35Albinism (HP:0001022)2.36329249
36Asymmetric septal hypertrophy (HP:0001670)2.35655182
37Recurrent fungal infections (HP:0002841)2.31695321
38Stomatitis (HP:0010280)2.31079376
39Type II lissencephaly (HP:0007260)2.30771182
40Recurrent gram-negative bacterial infections (HP:0005420)2.30197890
41Steatorrhea (HP:0002570)2.29084556
42Abnormality of polysaccharide metabolism (HP:0011012)2.27860246
43Abnormality of glycosaminoglycan metabolism (HP:0004371)2.27860246
44Abnormality of mucopolysaccharide metabolism (HP:0011020)2.27860246
45Constricted visual fields (HP:0001133)2.19471423
46Decreased central vision (HP:0007663)2.19237371
47Paralysis (HP:0003470)2.17660555
48Molar tooth sign on MRI (HP:0002419)2.17325664
49Abnormality of midbrain morphology (HP:0002418)2.17325664
50Optic neuritis (HP:0100653)2.15082903
51Retrobulbar optic neuritis (HP:0100654)2.15082903
52Pendular nystagmus (HP:0012043)2.10945828
53Myocardial infarction (HP:0001658)2.10735748
54Pancreatic fibrosis (HP:0100732)2.09187005
55Portal hypertension (HP:0001409)2.07549847
56Disinhibition (HP:0000734)2.07231395
57Pancreatic cysts (HP:0001737)2.04039497
58Oligomenorrhea (HP:0000876)2.01646862
59Hyperventilation (HP:0002883)2.01030505
60Widely patent fontanelles and sutures (HP:0004492)2.00615272
61Attenuation of retinal blood vessels (HP:0007843)1.98654991
62Abnormal drinking behavior (HP:0030082)1.97835909
63Polydipsia (HP:0001959)1.97835909
64Myositis (HP:0100614)1.96870220
65Loss of speech (HP:0002371)1.95505274
66Mucopolysacchariduria (HP:0008155)1.94484954
67Urinary glycosaminoglycan excretion (HP:0003541)1.94484954
68Nausea (HP:0002018)1.93328370
69Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.91616448
70Tubular atrophy (HP:0000092)1.91521695
71Inability to walk (HP:0002540)1.85586643
72Amyloidosis (HP:0011034)1.84983730
73Autoimmune thrombocytopenia (HP:0001973)1.83639781
74Abnormality of the renal cortex (HP:0011035)1.82229959
75Abnormality of the hepatic vasculature (HP:0006707)1.81766649
76Polygenic inheritance (HP:0010982)1.81708383
77Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.81674497
78Syncope (HP:0001279)1.79656555
79Cheilitis (HP:0100825)1.79541124
80Polyphagia (HP:0002591)1.79256440
81Upper motor neuron abnormality (HP:0002127)1.77253797
82Orchitis (HP:0100796)1.77027475
83Abnormality of the periventricular white matter (HP:0002518)1.76506721
84Progressive inability to walk (HP:0002505)1.74228635
85Frequent falls (HP:0002359)1.73697113
86True hermaphroditism (HP:0010459)1.73361023
87Progressive visual loss (HP:0000529)1.73195604
88Hypercholesterolemia (HP:0003124)1.72375139
89Mediastinal lymphadenopathy (HP:0100721)1.70902653
90Pachygyria (HP:0001302)1.69625595
913-Methylglutaconic aciduria (HP:0003535)1.67394114
92Agnosia (HP:0010524)1.67250614
93Pustule (HP:0200039)1.66836023
94Hemiplegia (HP:0002301)1.65274347
95Acute necrotizing encephalopathy (HP:0006965)1.65127763
96Hepatosplenomegaly (HP:0001433)1.64900447
97Macular degeneration (HP:0000608)1.62730310
98Abnormal urine output (HP:0012590)1.62484929
99Pulmonary embolism (HP:0002204)1.60403109
100Cerebral hemorrhage (HP:0001342)1.60001211

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ADRBK23.24612745
2TIE13.10181771
3FRK3.05032838
4BLK2.99775930
5GRK72.78789869
6PINK12.30104904
7DAPK22.27404964
8TYK21.89924005
9ACVR1B1.87382897
10CAMKK21.83757214
11WNK41.82788543
12OBSCN1.78377552
13RIPK41.70271571
14PIK3CG1.70236455
15INSRR1.68207340
16CAMK1D1.67116148
17TAOK31.63995313
18FES1.63435122
19TEC1.57910167
20CSF1R1.56796388
21ITK1.50176612
22GRK11.42829857
23JAK31.41175557
24CSK1.39027801
25CAMK1G1.36567941
26SYK1.35354151
27TTN1.34751581
28BMPR1B1.31556065
29PTK2B1.25949950
30MAP4K21.23777172
31NEK91.19212854
32OXSR11.10584627
33MAP3K141.09645293
34SGK21.07946809
35FGR1.07062260
36PIM21.06629729
37KDR1.03510551
38IKBKB1.03007245
39TGFBR21.00437968
40BTK1.00170904
41RPS6KA20.99564223
42PRKCQ0.96141754
43WNK30.94702700
44STK390.93699849
45PHKG20.92745746
46PHKG10.92745746
47TXK0.92467752
48KIT0.91815005
49MAP2K30.89797920
50CAMKK10.89729934
51MAPK130.85576492
52ZAK0.85061344
53LYN0.84301346
54SGK30.83014629
55ADRBK10.82143519
56MAP3K130.81749311
57TRPM70.81072345
58MAPKAPK30.80971544
59RPS6KA60.80416922
60NTRK30.76427149
61PDK10.76226909
62EPHB10.75715250
63HCK0.75694821
64MAP2K60.74575571
65MAPK120.72873805
66SGK2230.72645308
67SGK4940.72645308
68LCK0.72105058
69CDC42BPA0.69479429
70PDK20.69303887
71CAMK10.67343573
72MAP4K10.64897061
73IRAK10.62949581
74JAK20.62490253
75RPS6KL10.62041572
76RPS6KC10.62041572
77MATK0.60618689
78NUAK10.59383692
79PDPK10.58418880
80PNCK0.56519757
81MOS0.55267325
82NTRK20.55092382
83PRKG20.54150311
84ABL20.53794643
85BCKDK0.53686914
86PRKG10.52280660
87PRKCE0.52226533
88PRKACA0.51757436
89ABL10.47902510
90TLK10.47747674
91STK110.47404710
92TRIM280.46769558
93PRKAA20.46702492
94MARK30.46548131
95ZAP700.45855944
96PKN10.45777119
97FER0.45460373
98PRKACG0.43214163
99MAP3K110.42689208
100DYRK20.42402628

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.56371543
2Staphylococcus aureus infection_Homo sapiens_hsa051503.15518639
3Intestinal immune network for IgA production_Homo sapiens_hsa046723.14719947
4Allograft rejection_Homo sapiens_hsa053302.94511167
5Hematopoietic cell lineage_Homo sapiens_hsa046402.71979401
6Rheumatoid arthritis_Homo sapiens_hsa053232.60962759
7Lysosome_Homo sapiens_hsa041422.56354782
8Graft-versus-host disease_Homo sapiens_hsa053322.54117923
9Autoimmune thyroid disease_Homo sapiens_hsa053202.53407132
10Linoleic acid metabolism_Homo sapiens_hsa005912.41028206
11Type I diabetes mellitus_Homo sapiens_hsa049402.26801202
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.22203556
13Collecting duct acid secretion_Homo sapiens_hsa049662.10626402
14Leishmaniasis_Homo sapiens_hsa051402.07550594
15Tuberculosis_Homo sapiens_hsa051522.07413084
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.89250935
17Phagosome_Homo sapiens_hsa041451.83702184
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.74382631
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.65593600
20Oxidative phosphorylation_Homo sapiens_hsa001901.63203622
21Steroid biosynthesis_Homo sapiens_hsa001001.60540742
22Osteoclast differentiation_Homo sapiens_hsa043801.49320522
23Ether lipid metabolism_Homo sapiens_hsa005651.42389461
24Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.35399911
25Other glycan degradation_Homo sapiens_hsa005111.31818648
26Antigen processing and presentation_Homo sapiens_hsa046121.28499180
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23574666
28Primary bile acid biosynthesis_Homo sapiens_hsa001201.21392849
29Tryptophan metabolism_Homo sapiens_hsa003801.17022589
30Viral myocarditis_Homo sapiens_hsa054161.16245614
31Arachidonic acid metabolism_Homo sapiens_hsa005901.14772292
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.12897209
33Chemokine signaling pathway_Homo sapiens_hsa040621.11781038
34Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.10996165
35NOD-like receptor signaling pathway_Homo sapiens_hsa046211.09232308
36Phototransduction_Homo sapiens_hsa047441.08799266
37Sulfur metabolism_Homo sapiens_hsa009201.08422355
38Serotonergic synapse_Homo sapiens_hsa047261.02371627
39Pertussis_Homo sapiens_hsa051331.01628752
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.98860059
41Morphine addiction_Homo sapiens_hsa050320.97207283
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94186078
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92790445
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89560468
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88165289
46Regulation of autophagy_Homo sapiens_hsa041400.85102979
47Parkinsons disease_Homo sapiens_hsa050120.84365728
48SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81335300
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.77597993
50Ovarian steroidogenesis_Homo sapiens_hsa049130.77021070
51Toxoplasmosis_Homo sapiens_hsa051450.75910182
52Cardiac muscle contraction_Homo sapiens_hsa042600.74279504
53Primary immunodeficiency_Homo sapiens_hsa053400.72919099
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71997966
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.71604305
56Malaria_Homo sapiens_hsa051440.71194657
57ABC transporters_Homo sapiens_hsa020100.71023242
58Legionellosis_Homo sapiens_hsa051340.67719224
59African trypanosomiasis_Homo sapiens_hsa051430.66956790
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66460308
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65837894
62Platelet activation_Homo sapiens_hsa046110.64878271
63PPAR signaling pathway_Homo sapiens_hsa033200.63454475
64GABAergic synapse_Homo sapiens_hsa047270.63002797
65Alzheimers disease_Homo sapiens_hsa050100.62662855
66Renin secretion_Homo sapiens_hsa049240.62568069
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62553571
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.61899597
69Oxytocin signaling pathway_Homo sapiens_hsa049210.60726043
70Influenza A_Homo sapiens_hsa051640.59082995
71Glutamatergic synapse_Homo sapiens_hsa047240.58210901
72Complement and coagulation cascades_Homo sapiens_hsa046100.56887890
73Dorso-ventral axis formation_Homo sapiens_hsa043200.53686274
74B cell receptor signaling pathway_Homo sapiens_hsa046620.52029927
75Circadian entrainment_Homo sapiens_hsa047130.50863979
76NF-kappa B signaling pathway_Homo sapiens_hsa040640.49397087
77Peroxisome_Homo sapiens_hsa041460.49196368
78Nitrogen metabolism_Homo sapiens_hsa009100.48076000
79Olfactory transduction_Homo sapiens_hsa047400.47784731
80Butanoate metabolism_Homo sapiens_hsa006500.46955235
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45057176
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44447644
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43906453
84TNF signaling pathway_Homo sapiens_hsa046680.39894499
85Cholinergic synapse_Homo sapiens_hsa047250.38862296
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.36755285
87Synaptic vesicle cycle_Homo sapiens_hsa047210.34162362
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33176009
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30993932
90Gastric acid secretion_Homo sapiens_hsa049710.30195653
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28980731
92beta-Alanine metabolism_Homo sapiens_hsa004100.27095242
93Vibrio cholerae infection_Homo sapiens_hsa051100.26866944
94Huntingtons disease_Homo sapiens_hsa050160.26238867
95Measles_Homo sapiens_hsa051620.26202566
96Mineral absorption_Homo sapiens_hsa049780.25925819
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.25567596
98Calcium signaling pathway_Homo sapiens_hsa040200.25078311
99Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.24517495
100Histidine metabolism_Homo sapiens_hsa003400.23903515

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