ZNF367

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic chromosome condensation (GO:0007076)7.29765445
2DNA unwinding involved in DNA replication (GO:0006268)7.28876218
3nuclear pore complex assembly (GO:0051292)6.58862184
4mitotic sister chromatid cohesion (GO:0007064)6.15246964
5DNA strand elongation involved in DNA replication (GO:0006271)6.09095736
6DNA strand elongation (GO:0022616)5.98685342
7mitotic sister chromatid segregation (GO:0000070)5.90321434
8sister chromatid segregation (GO:0000819)5.69690949
9nuclear pore organization (GO:0006999)5.66496079
10telomere maintenance via semi-conservative replication (GO:0032201)5.52068606
11protein localization to chromosome, centromeric region (GO:0071459)5.44926985
12DNA replication initiation (GO:0006270)5.19646339
13regulation of centriole replication (GO:0046599)5.18481098
14DNA replication checkpoint (GO:0000076)4.87508516
15regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.86730652
16mitotic metaphase plate congression (GO:0007080)4.84641723
17pore complex assembly (GO:0046931)4.76615357
18protein localization to kinetochore (GO:0034501)4.76182877
19kinetochore organization (GO:0051383)4.75376424
20telomere maintenance via recombination (GO:0000722)4.74517585
21mitotic recombination (GO:0006312)4.73289270
22regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.58089415
23meiotic chromosome segregation (GO:0045132)4.51575621
24metaphase plate congression (GO:0051310)4.41677854
25chromosome condensation (GO:0030261)4.39360170
26CENP-A containing nucleosome assembly (GO:0034080)4.36058723
27DNA topological change (GO:0006265)4.26245931
28chromatin remodeling at centromere (GO:0031055)4.23473071
29mitotic nuclear envelope disassembly (GO:0007077)4.20801031
30regulation of centrosome cycle (GO:0046605)4.06440945
31DNA duplex unwinding (GO:0032508)4.05663567
32regulation of sister chromatid cohesion (GO:0007063)4.03336726
33establishment of chromosome localization (GO:0051303)4.01266505
34nucleotide-excision repair, DNA gap filling (GO:0006297)3.99181896
35membrane disassembly (GO:0030397)3.95709582
36nuclear envelope disassembly (GO:0051081)3.95709582
37regulation of DNA endoreduplication (GO:0032875)3.94563678
38DNA geometric change (GO:0032392)3.92020227
39regulation of centrosome duplication (GO:0010824)3.91667351
40DNA packaging (GO:0006323)3.91663488
41translesion synthesis (GO:0019985)3.90688103
42DNA conformation change (GO:0071103)3.83222951
43DNA synthesis involved in DNA repair (GO:0000731)3.77898889
44microtubule depolymerization (GO:0007019)3.72862803
45chromosome segregation (GO:0007059)3.70850101
46regulation of mitotic spindle organization (GO:0060236)3.70672030
47DNA replication-independent nucleosome assembly (GO:0006336)3.63376162
48DNA replication-independent nucleosome organization (GO:0034724)3.63376162
49regulation of chromosome segregation (GO:0051983)3.56808388
50positive regulation of DNA-dependent DNA replication (GO:2000105)3.52670992
51protein localization to chromosome (GO:0034502)3.50463498
52chromatin assembly or disassembly (GO:0006333)3.50340020
53regulation of spindle organization (GO:0090224)3.50140953
54positive regulation of chromosome segregation (GO:0051984)3.49802887
55telomere maintenance via telomere lengthening (GO:0010833)3.44980006
56DNA replication-dependent nucleosome organization (GO:0034723)3.44299996
57DNA replication-dependent nucleosome assembly (GO:0006335)3.44299996
58establishment of integrated proviral latency (GO:0075713)3.39602648
59kinetochore assembly (GO:0051382)3.39506879
60sister chromatid cohesion (GO:0007062)3.38741830
61heterochromatin organization (GO:0070828)3.36451953
62DNA ligation (GO:0006266)3.35246310
63histone exchange (GO:0043486)3.33042036
64postreplication repair (GO:0006301)3.27662309
65regulation of histone H3-K9 methylation (GO:0051570)3.25325561
66non-recombinational repair (GO:0000726)3.21610417
67double-strand break repair via nonhomologous end joining (GO:0006303)3.21610417
68spindle assembly involved in mitosis (GO:0090307)3.20565184
69deoxyribonucleotide biosynthetic process (GO:0009263)3.17929920
70mitotic cell cycle (GO:0000278)3.17807824
71regulation of RNA export from nucleus (GO:0046831)3.17671714
72spindle assembly (GO:0051225)3.17005657
73negative regulation of chromosome segregation (GO:0051985)3.15799181
74folic acid-containing compound biosynthetic process (GO:0009396)3.15676323
75negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.10773138
76regulation of DNA-dependent DNA replication (GO:0090329)3.09865829
77nuclear envelope organization (GO:0006998)3.09731151
78spindle organization (GO:0007051)3.09450868
79regulation of mitotic metaphase/anaphase transition (GO:0030071)3.09064406
80regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.09064406
81DNA replication (GO:0006260)3.08051053
82regulation of double-strand break repair via homologous recombination (GO:0010569)3.07458169
83microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.06868849
84spindle checkpoint (GO:0031577)3.04753616
85cellular protein complex localization (GO:0034629)3.03127970
86negative regulation of mitotic sister chromatid separation (GO:2000816)3.00388489
87negative regulation of sister chromatid segregation (GO:0033046)3.00388489
88negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.00388489
89negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.00388489
90negative regulation of mitotic sister chromatid segregation (GO:0033048)3.00388489
91somatic hypermutation of immunoglobulin genes (GO:0016446)2.99778758
92somatic diversification of immune receptors via somatic mutation (GO:0002566)2.99778758
93mitotic G2/M transition checkpoint (GO:0044818)2.99740095
94ATP-dependent chromatin remodeling (GO:0043044)2.99559425
95regulation of mitotic sister chromatid separation (GO:0010965)2.99452212
96regulation of mitotic sister chromatid segregation (GO:0033047)2.99452212
97regulation of sister chromatid segregation (GO:0033045)2.99452212
98telomere maintenance (GO:0000723)2.98724367
99chromosome organization (GO:0051276)2.97939141
100positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.97327163

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.63530452
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.98128933
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.20981682
4AR_21909140_ChIP-Seq_LNCAP_Human3.45437193
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.28402156
6* E2F1_21310950_ChIP-Seq_MCF-7_Human2.89667523
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.72009647
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.69834550
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.67088351
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.29310241
11KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.28866277
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.25610772
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.21686082
14* MYC_22102868_ChIP-Seq_BL_Human2.08851172
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.03469207
16E2F7_22180533_ChIP-Seq_HELA_Human12.9372581
17MYC_18358816_ChIP-ChIP_MESCs_Mouse1.95456040
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.91906406
19CREB1_15753290_ChIP-ChIP_HEK293T_Human1.87434335
20MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84605598
21DCP1A_22483619_ChIP-Seq_HELA_Human1.78493698
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.76347050
23MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.75557951
24ZFX_18555785_ChIP-Seq_MESCs_Mouse1.72645346
25XRN2_22483619_ChIP-Seq_HELA_Human1.68187500
26POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65548747
27PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.59275380
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57576986
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.53238017
30TTF2_22483619_ChIP-Seq_HELA_Human1.52881359
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49988419
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.44964294
33E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.44317648
34DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.39376593
35CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.36139013
36CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.35499622
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34768582
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.34504431
39ELK1_19687146_ChIP-ChIP_HELA_Human1.34344299
40ZNF263_19887448_ChIP-Seq_K562_Human1.33175727
41KDM5A_27292631_Chip-Seq_BREAST_Human1.30970601
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30754156
43KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29569937
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27649320
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.25785002
46ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22457109
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.22265716
48PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21219389
49EST1_17652178_ChIP-ChIP_JURKAT_Human1.21062586
50ESR1_15608294_ChIP-ChIP_MCF-7_Human1.20509100
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18996462
52FOXP3_21729870_ChIP-Seq_TREG_Human1.18802388
53CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.18371357
54CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17374263
55CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14575376
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.12954906
57ETS1_20019798_ChIP-Seq_JURKAT_Human1.11164461
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.09910469
59HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09596129
60GABP_19822575_ChIP-Seq_HepG2_Human1.08902041
61TP63_19390658_ChIP-ChIP_HaCaT_Human1.08131080
62JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.06129544
63CIITA_25753668_ChIP-Seq_RAJI_Human1.05252117
64* TFEB_21752829_ChIP-Seq_HELA_Human1.01237414
65VDR_23849224_ChIP-Seq_CD4+_Human1.00942057
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00236008
67* CHD1_26751641_Chip-Seq_LNCaP_Human0.99541709
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95101781
69VDR_21846776_ChIP-Seq_THP-1_Human0.93029496
70MYB_21317192_ChIP-Seq_ERMYB_Mouse0.91435540
71SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.90722006
72GABP_17652178_ChIP-ChIP_JURKAT_Human0.90145297
73GATA1_22025678_ChIP-Seq_K562_Human0.88972816
74SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.88315129
75KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.88274093
76TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.86699981
77NANOG_21062744_ChIP-ChIP_HESCs_Human0.86356625
78GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86310645
79PKCTHETA_26484144_Chip-Seq_BREAST_Human0.84810673
80STAT3_1855785_ChIP-Seq_MESCs_Mouse0.84479661
81SOX2_18555785_ChIP-Seq_MESCs_Mouse0.83604896
82SOX17_20123909_ChIP-Seq_XEN_Mouse0.82900755
83POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.82194024
84TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.79355557
85SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.78415042
86NCOR1_26117541_ChIP-Seq_K562_Human0.76967582
87NOTCH1_21737748_ChIP-Seq_TLL_Human0.76632872
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.76341601
89SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.75296710
90TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.74798625
91TCF7_22412390_ChIP-Seq_EML_Mouse0.74717738
92ELF1_17652178_ChIP-ChIP_JURKAT_Human0.74659869
93KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.74231027
94FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.73783181
95TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.73122329
96NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.72695703
97TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.71143705
98KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.70342182
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.70295720
100EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.69765735

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.62438936
2MP0008057_abnormal_DNA_replication5.11898852
3MP0003111_abnormal_nucleus_morphology4.68792354
4MP0003693_abnormal_embryo_hatching4.26778710
5MP0003077_abnormal_cell_cycle3.89288814
6MP0004957_abnormal_blastocyst_morpholog3.81480764
7MP0008058_abnormal_DNA_repair3.03716494
8MP0002877_abnormal_melanocyte_morpholog2.94335728
9MP0010352_gastrointestinal_tract_polyps2.85280600
10MP0008932_abnormal_embryonic_tissue2.67977490
11MP0003705_abnormal_hypodermis_morpholog2.36995414
12MP0008007_abnormal_cellular_replicative2.28685050
13MP0000350_abnormal_cell_proliferation2.22955947
14MP0001730_embryonic_growth_arrest2.17257361
15MP0002009_preneoplasia2.06162614
16MP0005076_abnormal_cell_differentiation1.99734974
17MP0010307_abnormal_tumor_latency1.99231802
18MP0004185_abnormal_adipocyte_glucose1.88068161
19MP0002396_abnormal_hematopoietic_system1.85106913
20MP0004808_abnormal_hematopoietic_stem1.78093960
21MP0009697_abnormal_copulation1.77472710
22MP0001697_abnormal_embryo_size1.76671153
23MP0001672_abnormal_embryogenesis/_devel1.65596428
24MP0005380_embryogenesis_phenotype1.65596428
25MP0002080_prenatal_lethality1.56603830
26MP0000490_abnormal_crypts_of1.51364687
27MP0003984_embryonic_growth_retardation1.48482646
28MP0003566_abnormal_cell_adhesion1.48140608
29MP0000313_abnormal_cell_death1.46278586
30MP0002088_abnormal_embryonic_growth/wei1.40876015
31MP0005464_abnormal_platelet_physiology1.39920854
32MP0002086_abnormal_extraembryonic_tissu1.37115456
33MP0003890_abnormal_embryonic-extraembry1.37100048
34MP0003786_premature_aging1.32691335
35MP0002085_abnormal_embryonic_tissue1.31741658
36MP0010234_abnormal_vibrissa_follicle1.30542030
37MP0005501_abnormal_skin_physiology1.29096092
38MP0004197_abnormal_fetal_growth/weight/1.29034469
39MP0005623_abnormal_meninges_morphology1.27454877
40MP0002019_abnormal_tumor_incidence1.27186201
41MP0000537_abnormal_urethra_morphology1.27172861
42MP0002084_abnormal_developmental_patter1.25260099
43MP0009053_abnormal_anal_canal1.19577805
44MP0001346_abnormal_lacrimal_gland1.19275180
45MP0003656_abnormal_erythrocyte_physiolo1.15571150
46MP0005621_abnormal_cell_physiology1.14731593
47MP0003950_abnormal_plasma_membrane1.08309747
48MP0009672_abnormal_birth_weight1.05339039
49MP0000358_abnormal_cell_content/1.04264369
50MP0002697_abnormal_eye_size1.03590233
51MP0002210_abnormal_sex_determination1.02141237
52MP0005384_cellular_phenotype1.00442227
53MP0000703_abnormal_thymus_morphology0.94568391
54MP0000428_abnormal_craniofacial_morphol0.94222005
55MP0002160_abnormal_reproductive_system0.93670599
56MP0004233_abnormal_muscle_weight0.92419291
57MP0003763_abnormal_thymus_physiology0.89410695
58MP0003453_abnormal_keratinocyte_physiol0.88098142
59MP0001286_abnormal_eye_development0.85428438
60MP0002166_altered_tumor_susceptibility0.85120465
61MP0003937_abnormal_limbs/digits/tail_de0.84472511
62MP0002092_abnormal_eye_morphology0.84059434
63MP0003221_abnormal_cardiomyocyte_apopto0.83826126
64MP0001929_abnormal_gametogenesis0.83688524
65MP0001661_extended_life_span0.83400282
66MP0002398_abnormal_bone_marrow0.83276952
67MP0006035_abnormal_mitochondrial_morpho0.81554849
68MP0001145_abnormal_male_reproductive0.81454132
69MP0003943_abnormal_hepatobiliary_system0.80922003
70MP0002796_impaired_skin_barrier0.80795908
71MP0005451_abnormal_body_composition0.79959337
72MP0002006_tumorigenesis0.79486903
73MP0003091_abnormal_cell_migration0.74589912
74MP0003718_maternal_effect0.74114474
75MP0005666_abnormal_adipose_tissue0.73472734
76MP0000627_abnormal_mammary_gland0.73049596
77MP0009703_decreased_birth_body0.71970312
78MP0002111_abnormal_tail_morphology0.70256634
79MP0001293_anophthalmia0.69818105
80MP0001727_abnormal_embryo_implantation0.69081561
81MP0010678_abnormal_skin_adnexa0.68407024
82MP0000653_abnormal_sex_gland0.67297101
83MP0000015_abnormal_ear_pigmentation0.66769271
84MP0001216_abnormal_epidermal_layer0.65962273
85MP0003699_abnormal_female_reproductive0.65678376
86MP0002722_abnormal_immune_system0.64493658
87MP0001348_abnormal_lacrimal_gland0.63499023
88MP0002060_abnormal_skin_morphology0.62488117
89MP0001849_ear_inflammation0.61365271
90MP0000432_abnormal_head_morphology0.59907212
91MP0002970_abnormal_white_adipose0.58848596
92MP0003941_abnormal_skin_development0.58570953
93MP0005409_darkened_coat_color0.58264193
94MP0005171_absent_coat_pigmentation0.57594776
95MP0001915_intracranial_hemorrhage0.57125952
96MP0003935_abnormal_craniofacial_develop0.56614717
97MP0005083_abnormal_biliary_tract0.55389063
98MP0001119_abnormal_female_reproductive0.55253637
99MP0000383_abnormal_hair_follicle0.54602779
100MP0003315_abnormal_perineum_morphology0.54331491

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)7.14020610
2Chromsome breakage (HP:0040012)6.47518071
3Abnormality of chromosome stability (HP:0003220)4.03951670
4Aplasia/Hypoplasia of the uvula (HP:0010293)3.93334549
5Abnormality of the preputium (HP:0100587)3.85463428
6Meckel diverticulum (HP:0002245)3.66160634
7Birth length less than 3rd percentile (HP:0003561)3.53875523
8Abnormality of the ileum (HP:0001549)3.39796387
9Increased mean platelet volume (HP:0011877)3.39347140
10Myelodysplasia (HP:0002863)3.28157513
11Increased nuchal translucency (HP:0010880)3.25505877
12Small intestinal stenosis (HP:0012848)3.16363260
13Duodenal stenosis (HP:0100867)3.16363260
14Abnormal platelet volume (HP:0011876)3.06029116
15Abnormality of the carotid arteries (HP:0005344)2.98804622
16Deep philtrum (HP:0002002)2.81044947
17Ectopic kidney (HP:0000086)2.77792235
18Leiomyosarcoma (HP:0100243)2.73207627
19Uterine leiomyosarcoma (HP:0002891)2.73207627
20Nephroblastoma (Wilms tumor) (HP:0002667)2.67698569
21Clubbing of toes (HP:0100760)2.67399225
22Selective tooth agenesis (HP:0001592)2.59397728
23Cafe-au-lait spot (HP:0000957)2.57055832
24Proximal placement of thumb (HP:0009623)2.53298535
25Overlapping toe (HP:0001845)2.52646814
26Embryonal renal neoplasm (HP:0011794)2.51083566
27Abnormality of the duodenum (HP:0002246)2.50671191
28Deviation of the thumb (HP:0009603)2.49592867
29Reticulocytopenia (HP:0001896)2.44658021
30Volvulus (HP:0002580)2.41835030
31Gastrointestinal carcinoma (HP:0002672)2.41751234
32Malignant gastrointestinal tract tumors (HP:0006749)2.41751234
33Acanthocytosis (HP:0001927)2.36384379
34Progressive muscle weakness (HP:0003323)2.36091544
35Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.32087457
36Cortical dysplasia (HP:0002539)2.28858448
37Transitional cell carcinoma of the bladder (HP:0006740)2.27859240
38Ankyloglossia (HP:0010296)2.27805535
39Poikilocytosis (HP:0004447)2.24638005
40Squamous cell carcinoma (HP:0002860)2.22446973
41Absent radius (HP:0003974)2.22037441
42Aplasia/Hypoplasia of the sacrum (HP:0008517)2.21894737
43Asymmetry of the thorax (HP:0001555)2.21734158
44Menorrhagia (HP:0000132)2.19979285
45Arteriovenous malformation (HP:0100026)2.18413593
46Breast hypoplasia (HP:0003187)2.17640996
47Missing ribs (HP:0000921)2.15962715
48Abnormality of chromosome segregation (HP:0002916)2.13671507
49Poikiloderma (HP:0001029)2.13563333
50Short thumb (HP:0009778)2.12707688
51Progressive external ophthalmoplegia (HP:0000590)2.11643594
52Bladder neoplasm (HP:0009725)2.10568897
53Bladder carcinoma (HP:0002862)2.10568897
54Hyperacusis (HP:0010780)2.07487995
55Abnormality of DNA repair (HP:0003254)2.07072624
56Sloping forehead (HP:0000340)2.06459553
57Duplicated collecting system (HP:0000081)2.04149648
58Cutaneous melanoma (HP:0012056)2.02128997
59Aplasia involving forearm bones (HP:0009822)2.01641648
60Absent forearm bone (HP:0003953)2.01641648
61Termporal pattern (HP:0011008)1.99710616
62Insidious onset (HP:0003587)1.99710616
63Facial hemangioma (HP:0000329)1.99663984
64Abnormality of the fetal cardiovascular system (HP:0010948)1.99075927
65Abnormal umbilical cord blood vessels (HP:0011403)1.99075927
66Single umbilical artery (HP:0001195)1.99075927
67Insomnia (HP:0100785)1.95736417
68Spinal cord lesions (HP:0100561)1.95533440
69Syringomyelia (HP:0003396)1.95533440
70Choanal atresia (HP:0000453)1.95344028
71Triphalangeal thumb (HP:0001199)1.92824241
72Medulloblastoma (HP:0002885)1.92639806
73Orthostatic hypotension (HP:0001278)1.92252924
74Abnormality of the umbilical cord (HP:0010881)1.91545531
75Acute myeloid leukemia (HP:0004808)1.90129811
7611 pairs of ribs (HP:0000878)1.88617960
77Abnormality of oral frenula (HP:0000190)1.87557764
78Duplication of thumb phalanx (HP:0009942)1.87469952
79Prominent nose (HP:0000448)1.86846654
80Neoplasm of the colon (HP:0100273)1.85271256
81Bone marrow hypocellularity (HP:0005528)1.84559757
82Heterotopia (HP:0002282)1.83532847
83IgA deficiency (HP:0002720)1.83143768
84Microglossia (HP:0000171)1.80412036
85Sandal gap (HP:0001852)1.80094083
86Microvesicular hepatic steatosis (HP:0001414)1.79894577
87Abnormality of reticulocytes (HP:0004312)1.76813904
88Embryonal neoplasm (HP:0002898)1.76701650
89Petechiae (HP:0000967)1.76446498
90Abnormality of cochlea (HP:0000375)1.75830448
91Abnormal lung lobation (HP:0002101)1.75091314
92High anterior hairline (HP:0009890)1.73692734
93Prolonged bleeding time (HP:0003010)1.73565270
94Absent thumb (HP:0009777)1.73438288
95Entropion (HP:0000621)1.73370206
96Atresia of the external auditory canal (HP:0000413)1.71150436
97Abnormal foot bone ossification (HP:0010675)1.70982836
98Abnormal auditory evoked potentials (HP:0006958)1.69339673
99Ureteral duplication (HP:0000073)1.69027339
100Uterine neoplasm (HP:0010784)1.67029334

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.66254905
2WEE13.72075093
3BUB13.34434680
4TTK3.06586662
5EIF2AK12.94467477
6BRSK22.91346905
7PLK42.72740072
8SMG12.40549606
9CDK122.27023943
10SCYL22.25729228
11MAP3K102.11571445
12NEK12.07042280
13TAF12.05561156
14SRPK12.04718086
15PNCK1.96421897
16CHEK21.87451914
17BRSK11.82954046
18PBK1.81504361
19BRD41.75174125
20ZAK1.72767543
21MST41.70784646
22EEF2K1.68566717
23NEK21.63656724
24CDK81.59588471
25LATS11.57162541
26PLK11.56940638
27PRPF4B1.55566327
28CDK71.54734271
29ATR1.49624779
30TSSK61.49553474
31PLK31.45177208
32EIF2AK31.42861293
33AURKB1.40308966
34IRAK31.37255053
35ERBB41.33275866
36RPS6KB21.29611539
37CDK41.28642295
38STK31.28634054
39TRIB31.26224388
40MELK1.25434455
41CHEK11.18882354
42MKNK11.18559427
43MKNK21.16363565
44LATS21.14136433
45VRK21.06031661
46MST1R1.04602026
47CDK61.03942966
48AURKA1.02890697
49ICK1.02549574
50VRK11.02442682
51MAP3K81.02139140
52STK41.00731526
53CDK90.90660312
54BMX0.84051332
55ATM0.82340894
56NEK90.80518961
57NME20.79332982
58TRIM280.78732086
59CCNB10.72983972
60RPS6KA40.69754197
61PAK40.67706534
62STK38L0.67606876
63PASK0.66242668
64BRAF0.65332019
65MAPK110.63994344
66CDK10.62827054
67CDK20.61456568
68DYRK30.61041811
69EIF2AK20.60760980
70PKN20.60124411
71TTN0.57006301
72CLK10.54808337
73EPHA20.54778264
74ERBB30.54517086
75MTOR0.53997850
76STK240.53686701
77MET0.53606261
78YES10.51106415
79TLK10.49454481
80AKT20.48791042
81STK100.48051988
82MAP3K140.43782117
83TAOK20.41957371
84PIM10.39327494
85SIK30.37434905
86SIK10.33996481
87RAF10.33980689
88IRAK20.32293004
89KSR20.32067635
90KSR10.30768344
91PAK20.30700024
92PAK10.30078263
93CDK30.29769389
94MAP2K30.29553546
95ILK0.28960501
96CDK140.27034552
97CAMK1G0.26212975
98MAPK140.25618841
99PDGFRA0.25287751
100CDK180.24859818

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.84579253
2Mismatch repair_Homo sapiens_hsa034304.72352608
3Cell cycle_Homo sapiens_hsa041103.72196376
4Fanconi anemia pathway_Homo sapiens_hsa034602.93817264
5Non-homologous end-joining_Homo sapiens_hsa034502.89579403
6Base excision repair_Homo sapiens_hsa034102.87252338
7Nucleotide excision repair_Homo sapiens_hsa034202.86216704
8Homologous recombination_Homo sapiens_hsa034402.73521035
9Spliceosome_Homo sapiens_hsa030402.35345920
10RNA transport_Homo sapiens_hsa030132.27779794
11One carbon pool by folate_Homo sapiens_hsa006702.14192114
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.07768705
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.93242193
14p53 signaling pathway_Homo sapiens_hsa041151.84041712
15mRNA surveillance pathway_Homo sapiens_hsa030151.71726473
16Systemic lupus erythematosus_Homo sapiens_hsa053221.67110654
17Chronic myeloid leukemia_Homo sapiens_hsa052201.63727710
18Thyroid cancer_Homo sapiens_hsa052161.60391035
19Viral carcinogenesis_Homo sapiens_hsa052031.56124725
20Pyrimidine metabolism_Homo sapiens_hsa002401.52394458
21Alcoholism_Homo sapiens_hsa050341.45919360
22Pancreatic cancer_Homo sapiens_hsa052121.45914389
23Small cell lung cancer_Homo sapiens_hsa052221.42164257
24Non-small cell lung cancer_Homo sapiens_hsa052231.36799668
25Bladder cancer_Homo sapiens_hsa052191.31754971
26MicroRNAs in cancer_Homo sapiens_hsa052061.28648542
27Oocyte meiosis_Homo sapiens_hsa041141.19574542
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.18251860
29Prostate cancer_Homo sapiens_hsa052151.17866082
30Biosynthesis of amino acids_Homo sapiens_hsa012301.14229369
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.10361835
32Pentose phosphate pathway_Homo sapiens_hsa000301.08071393
33Basal transcription factors_Homo sapiens_hsa030221.05964380
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02388076
35Colorectal cancer_Homo sapiens_hsa052100.98289540
36RNA degradation_Homo sapiens_hsa030180.97351421
37Endometrial cancer_Homo sapiens_hsa052130.95811289
38HTLV-I infection_Homo sapiens_hsa051660.94683534
39Hepatitis B_Homo sapiens_hsa051610.94348049
40Central carbon metabolism in cancer_Homo sapiens_hsa052300.93199861
41Glioma_Homo sapiens_hsa052140.88485380
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.86255135
43Melanoma_Homo sapiens_hsa052180.85571572
44Epstein-Barr virus infection_Homo sapiens_hsa051690.80492677
45Adherens junction_Homo sapiens_hsa045200.80315567
46Apoptosis_Homo sapiens_hsa042100.79139574
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.74857313
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74687971
49Acute myeloid leukemia_Homo sapiens_hsa052210.74205567
50Lysine degradation_Homo sapiens_hsa003100.73289368
51Renal cell carcinoma_Homo sapiens_hsa052110.71997504
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71901869
53Purine metabolism_Homo sapiens_hsa002300.69260779
54N-Glycan biosynthesis_Homo sapiens_hsa005100.69098098
55RNA polymerase_Homo sapiens_hsa030200.68763533
56Proteasome_Homo sapiens_hsa030500.67751545
57TGF-beta signaling pathway_Homo sapiens_hsa043500.65877366
58Shigellosis_Homo sapiens_hsa051310.62880479
59Vitamin B6 metabolism_Homo sapiens_hsa007500.62834912
60Hippo signaling pathway_Homo sapiens_hsa043900.61619527
61B cell receptor signaling pathway_Homo sapiens_hsa046620.61617555
62Herpes simplex infection_Homo sapiens_hsa051680.61617378
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60325277
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57179520
65Platelet activation_Homo sapiens_hsa046110.55929401
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55586550
67Carbon metabolism_Homo sapiens_hsa012000.53181443
68Ribosome_Homo sapiens_hsa030100.52829729
69Measles_Homo sapiens_hsa051620.49980775
70Proteoglycans in cancer_Homo sapiens_hsa052050.47399373
71Pathways in cancer_Homo sapiens_hsa052000.46810326
72ErbB signaling pathway_Homo sapiens_hsa040120.42131125
73Selenocompound metabolism_Homo sapiens_hsa004500.41847814
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.39897149
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37269396
76FoxO signaling pathway_Homo sapiens_hsa040680.34740786
77Inositol phosphate metabolism_Homo sapiens_hsa005620.34408477
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.34351668
79Gap junction_Homo sapiens_hsa045400.33934537
80mTOR signaling pathway_Homo sapiens_hsa041500.33872493
81Wnt signaling pathway_Homo sapiens_hsa043100.32699964
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32620540
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32268662
84Focal adhesion_Homo sapiens_hsa045100.32243794
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31779691
86Sulfur relay system_Homo sapiens_hsa041220.31291343
87Basal cell carcinoma_Homo sapiens_hsa052170.29694872
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.27822424
89Folate biosynthesis_Homo sapiens_hsa007900.26877572
90Pyruvate metabolism_Homo sapiens_hsa006200.26488028
91PI3K-Akt signaling pathway_Homo sapiens_hsa041510.25782765
92Choline metabolism in cancer_Homo sapiens_hsa052310.23532974
93T cell receptor signaling pathway_Homo sapiens_hsa046600.23521008
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23363093
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.23269498
96AMPK signaling pathway_Homo sapiens_hsa041520.23185596
97VEGF signaling pathway_Homo sapiens_hsa043700.22593791
98Insulin signaling pathway_Homo sapiens_hsa049100.22122919
99Influenza A_Homo sapiens_hsa051640.21621606
100ECM-receptor interaction_Homo sapiens_hsa045120.21043993

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