ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	tryptophan catabolic process (GO:0006569)	4.81266191
2	indole-containing compound catabolic process (GO:0042436)	4.81266191
3	indolalkylamine catabolic process (GO:0046218)	4.81266191
4	indolalkylamine metabolic process (GO:0006586)	4.55644773
5	monoubiquitinated protein deubiquitination (GO:0035520)	4.54543702
6	kynurenine metabolic process (GO:0070189)	4.49900726
7	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.19546628
8	signal peptide processing (GO:0006465)	4.14640685
9	tryptophan metabolic process (GO:0006568)	4.08491901
10	protein K11-linked deubiquitination (GO:0035871)	4.04473601
11	positive regulation of developmental pigmentation (GO:0048087)	4.01192934
12	regulation of establishment of cell polarity (GO:2000114)	3.98247883
13	regulation of hippo signaling (GO:0035330)	3.93287803
14	neural tube formation (GO:0001841)	3.83807950
15	regulation of pigment cell differentiation (GO:0050932)	3.82644025
16	establishment of protein localization to Golgi (GO:0072600)	3.66544830
17	behavioral response to ethanol (GO:0048149)	3.63718224
18	interkinetic nuclear migration (GO:0022027)	3.60536752
19	cytoplasmic mRNA processing body assembly (GO:0033962)	3.50658717
20	detection of light stimulus involved in sensory perception (GO:0050962)	3.47743983
21	detection of light stimulus involved in visual perception (GO:0050908)	3.47743983
22	behavioral response to nicotine (GO:0035095)	3.45346740
23	regulation of establishment or maintenance of cell polarity (GO:0032878)	3.39756722
24	reflex (GO:0060004)	3.39539796
25	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.38927287
26	indole-containing compound metabolic process (GO:0042430)	3.38340370
27	cellular ketone body metabolic process (GO:0046950)	3.36529395
28	snRNA transcription (GO:0009301)	3.35420125
29	regulation of sarcomere organization (GO:0060297)	3.33883787
30	photoreceptor cell maintenance (GO:0045494)	3.32369157
31	L-fucose catabolic process (GO:0042355)	3.30881908
32	fucose catabolic process (GO:0019317)	3.30881908
33	L-fucose metabolic process (GO:0042354)	3.30881908
34	UDP-N-acetylglucosamine metabolic process (GO:0006047)	3.30702720
35	cilium or flagellum-dependent cell motility (GO:0001539)	3.27473668
36	gamma-aminobutyric acid transport (GO:0015812)	3.17437988
37	protein K48-linked deubiquitination (GO:0071108)	3.10514209
38	protein prenylation (GO:0018342)	3.07805028
39	prenylation (GO:0097354)	3.07805028
40	phospholipid translocation (GO:0045332)	3.06935138
41	lipid translocation (GO:0034204)	3.06935138
42	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.06700531
43	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.06700531
44	regulation of translation, ncRNA-mediated (GO:0045974)	3.06700531
45	ketone body metabolic process (GO:1902224)	3.05336407
46	detection of mechanical stimulus involved in sensory perception (GO:0050974)	3.02115574
47	serotonin metabolic process (GO:0042428)	2.99177117
48	cellular response to sterol (GO:0036315)	2.96019321
49	tachykinin receptor signaling pathway (GO:0007217)	2.88235076
50	protein K63-linked deubiquitination (GO:0070536)	2.87307135
51	auditory receptor cell stereocilium organization (GO:0060088)	2.86254113
52	replication fork processing (GO:0031297)	2.86053135
53	thyroid hormone metabolic process (GO:0042403)	2.82525630
54	negative regulation of sodium ion transport (GO:0010766)	2.81786573
55	response to pheromone (GO:0019236)	2.80381023
56	primary amino compound metabolic process (GO:1901160)	2.78513830
57	cellular response to ethanol (GO:0071361)	2.75527607
58	central nervous system neuron axonogenesis (GO:0021955)	2.75319687
59	recombinational repair (GO:0000725)	2.74330389
60	double-strand break repair via homologous recombination (GO:0000724)	2.73618571
61	rRNA catabolic process (GO:0016075)	2.73057460
62	righting reflex (GO:0060013)	2.72902419
63	oxidative demethylation (GO:0070989)	2.71273481
64	benzene-containing compound metabolic process (GO:0042537)	2.71185208
65	negative regulation of mast cell activation (GO:0033004)	2.70638151
66	regulation of posttranscriptional gene silencing (GO:0060147)	2.68268321
67	regulation of gene silencing by miRNA (GO:0060964)	2.68268321
68	regulation of gene silencing by RNA (GO:0060966)	2.68268321
69	inner ear receptor stereocilium organization (GO:0060122)	2.67069541
70	cellular biogenic amine catabolic process (GO:0042402)	2.66602736
71	amine catabolic process (GO:0009310)	2.66602736
72	retinal cone cell development (GO:0046549)	2.64333133
73	neuronal action potential (GO:0019228)	2.64288158
74	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.63958185
75	protein targeting to Golgi (GO:0000042)	2.63226453
76	aromatic amino acid family catabolic process (GO:0009074)	2.61676392
77	microtubule anchoring (GO:0034453)	2.57597685
78	histone H3-K4 trimethylation (GO:0080182)	2.57064107
79	reciprocal DNA recombination (GO:0035825)	2.55477484
80	reciprocal meiotic recombination (GO:0007131)	2.55477484
81	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.54671727
82	regulation of action potential (GO:0098900)	2.53579600
83	proline transport (GO:0015824)	2.49867358
84	negative regulation of systemic arterial blood pressure (GO:0003085)	2.49334290
85	cilium organization (GO:0044782)	2.49049112
86	sex differentiation (GO:0007548)	2.47932954
87	cilium morphogenesis (GO:0060271)	2.47918711
88	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.47799409
89	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.47083419
90	regulation of memory T cell differentiation (GO:0043380)	2.47057375
91	cilium assembly (GO:0042384)	2.46019785
92	methionine biosynthetic process (GO:0009086)	2.45351074
93	NAD biosynthetic process (GO:0009435)	2.44083950
94	centrosome duplication (GO:0051298)	2.43511834
95	cAMP catabolic process (GO:0006198)	2.43322704
96	sulfation (GO:0051923)	2.43106923
97	negative regulation of keratinocyte proliferation (GO:0010839)	2.41619174
98	adaptation of signaling pathway (GO:0023058)	2.40763809
99	axoneme assembly (GO:0035082)	2.40621425
100	pericardium development (GO:0060039)	2.40005514

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.51865209
2	VDR_22108803_ChIP-Seq_LS180_Human	2.87961233
3	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.83114986
4	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.79018498
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.78606437
6	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.77699670
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.77073994
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.69816522
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.60413909
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.53580139
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.41150198
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.32560732
13	FUS_26573619_Chip-Seq_HEK293_Human	2.28777002
14	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.28473825
15	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.27222647
16	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.19601128
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.13649042
18	EWS_26573619_Chip-Seq_HEK293_Human	2.11284467
19	P300_19829295_ChIP-Seq_ESCs_Human	2.06790468
20	STAT3_23295773_ChIP-Seq_U87_Human	2.00756003
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.97156858
22	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.96965739
23	SMAD4_21799915_ChIP-Seq_A2780_Human	1.93267906
24	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.89941758
25	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.86932145
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.76290833
27	TCF4_23295773_ChIP-Seq_U87_Human	1.75063662
28	EZH2_22144423_ChIP-Seq_EOC_Human	1.72523296
29	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.72355454
30	AR_21572438_ChIP-Seq_LNCaP_Human	1.71700405
31	BCAT_22108803_ChIP-Seq_LS180_Human	1.70184963
32	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.69817718
33	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.66947788
34	CBP_20019798_ChIP-Seq_JUKART_Human	1.65722989
35	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.65722989
36	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.64661277
37	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.64590081
38	AR_25329375_ChIP-Seq_VCAP_Human	1.57167180
39	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.56927679
40	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.56812949
41	TP53_16413492_ChIP-PET_HCT116_Human	1.56676909
42	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.53067309
43	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.53067309
44	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.49113581
45	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.46915051
46	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.46050828
47	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.45435346
48	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.43985018
49	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.42186019
50	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.41813786
51	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.41219664
52	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.40902210
53	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.39781149
54	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.38087758
55	TCF4_22108803_ChIP-Seq_LS180_Human	1.37471078
56	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.36017317
57	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.34051172
58	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.33185008
59	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.31269702
60	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.30570425
61	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.30130784
62	RUNX2_22187159_ChIP-Seq_PCA_Human	1.30113095
63	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.29774937
64	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.29154123
65	AHR_22903824_ChIP-Seq_MCF-7_Human	1.28069595
66	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.27657186
67	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.25594502
68	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.24622714
69	CDX2_22108803_ChIP-Seq_LS180_Human	1.24091969
70	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.23839479
71	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.23126455
72	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.22395517
73	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.21768660
74	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.19350074
75	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.19290129
76	P53_22387025_ChIP-Seq_ESCs_Mouse	1.17824197
77	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.17507395
78	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.17399652
79	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.16752694
80	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.16536354
81	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.12219080
82	KDM2B_26808549_Chip-Seq_REH_Human	1.12008460
83	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.10998226
84	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.09494070
85	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.08859288
86	TP53_18474530_ChIP-ChIP_U2OS_Human	1.08741405
87	NANOG_19829295_ChIP-Seq_ESCs_Human	1.07500734
88	SOX2_19829295_ChIP-Seq_ESCs_Human	1.07500734
89	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.07187959
90	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.07161034
91	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.07116902
92	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.05903824
93	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.05732488
94	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.05732488
95	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.05142674
96	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.05039715
97	IRF1_19129219_ChIP-ChIP_H3396_Human	1.04975052
98	P300_18555785_Chip-Seq_ESCs_Mouse	1.04028246
99	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.02610056
100	TBL1_22424771_ChIP-Seq_293T_Human	1.01743006

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	5.34317063
2	MP0008057_abnormal_DNA_replication	3.88724327
3	MP0003195_calcinosis	3.80074974
4	MP0005551_abnormal_eye_electrophysiolog	2.56014648
5	MP0009046_muscle_twitch	2.37421579
6	MP0000427_abnormal_hair_cycle	2.35365293
7	MP0001501_abnormal_sleep_pattern	2.14933955
8	MP0000383_abnormal_hair_follicle	2.11796728
9	MP0005174_abnormal_tail_pigmentation	2.09699780
10	MP0001968_abnormal_touch/_nociception	2.08561894
11	MP0003950_abnormal_plasma_membrane	2.02733359
12	MP0008877_abnormal_DNA_methylation	2.02281964
13	MP0003646_muscle_fatigue	1.89547965
14	MP0005253_abnormal_eye_physiology	1.87231978
15	MP0005646_abnormal_pituitary_gland	1.86777972
16	MP0004043_abnormal_pH_regulation	1.83885226
17	MP0009745_abnormal_behavioral_response	1.79164378
18	MP0000372_irregular_coat_pigmentation	1.66941942
19	MP0002938_white_spotting	1.62525272
20	MP0003045_fibrosis	1.60070197
21	MP0002736_abnormal_nociception_after	1.59705338
22	MP0001986_abnormal_taste_sensitivity	1.58377629
23	MP0002876_abnormal_thyroid_physiology	1.57282751
24	MP0002102_abnormal_ear_morphology	1.57114823
25	MP0005645_abnormal_hypothalamus_physiol	1.56793919
26	MP0006072_abnormal_retinal_apoptosis	1.46257629
27	MP0003252_abnormal_bile_duct	1.44764260
28	MP0001486_abnormal_startle_reflex	1.44297123
29	MP0002837_dystrophic_cardiac_calcinosis	1.43851322
30	MP0000371_diluted_coat_color	1.43193481
31	MP0003787_abnormal_imprinting	1.39840397
32	MP0002638_abnormal_pupillary_reflex	1.36453358
33	MP0010386_abnormal_urinary_bladder	1.35811484
34	MP0002272_abnormal_nervous_system	1.34650085
35	MP0004924_abnormal_behavior	1.33504357
36	MP0005386_behavior/neurological_phenoty	1.33504357
37	MP0003136_yellow_coat_color	1.32441510
38	MP0003890_abnormal_embryonic-extraembry	1.31632120
39	MP0010678_abnormal_skin_adnexa	1.31611466
40	MP0002064_seizures	1.31514345
41	MP0003880_abnormal_central_pattern	1.30751158
42	MP0002168_other_aberrant_phenotype	1.30036142
43	MP0000631_abnormal_neuroendocrine_gland	1.28700767
44	MP0000015_abnormal_ear_pigmentation	1.28321413
45	MP0005171_absent_coat_pigmentation	1.28320574
46	MP0004215_abnormal_myocardial_fiber	1.24522839
47	MP0001485_abnormal_pinna_reflex	1.22273199
48	MP0002095_abnormal_skin_pigmentation	1.20522829
49	MP0006276_abnormal_autonomic_nervous	1.19818431
50	MP0002928_abnormal_bile_duct	1.18905492
51	MP0004145_abnormal_muscle_electrophysio	1.18076978
52	MP0003718_maternal_effect	1.18024760
53	MP0004142_abnormal_muscle_tone	1.16881990
54	MP0002572_abnormal_emotion/affect_behav	1.15503577
55	MP0009697_abnormal_copulation	1.13598665
56	MP0008872_abnormal_physiological_respon	1.12172745
57	MP0004147_increased_porphyrin_level	1.12036145
58	MP0009780_abnormal_chondrocyte_physiolo	1.11545755
59	MP0005310_abnormal_salivary_gland	1.10272471
60	MP0005395_other_phenotype	1.09345057
61	MP0002735_abnormal_chemical_nociception	1.08668051
62	MP0001984_abnormal_olfaction	1.06113189
63	MP0003635_abnormal_synaptic_transmissio	1.03961860
64	MP0002067_abnormal_sensory_capabilities	1.03856738
65	MP0008961_abnormal_basal_metabolism	1.03365738
66	MP0006054_spinal_hemorrhage	1.01660421
67	MP0010094_abnormal_chromosome_stability	1.01660082
68	MP0002557_abnormal_social/conspecific_i	1.00648196
69	MP0003943_abnormal_hepatobiliary_system	0.96699652
70	MP0002234_abnormal_pharynx_morphology	0.96567758
71	MP0005075_abnormal_melanosome_morpholog	0.96430832
72	MP0005187_abnormal_penis_morphology	0.96364713
73	MP0008058_abnormal_DNA_repair	0.94023766
74	MP0002138_abnormal_hepatobiliary_system	0.93614758
75	MP0003633_abnormal_nervous_system	0.90378854
76	MP0005647_abnormal_sex_gland	0.90237234
77	MP0003937_abnormal_limbs/digits/tail_de	0.89568099
78	MP0004130_abnormal_muscle_cell	0.88097289
79	MP0006292_abnormal_olfactory_placode	0.87831832
80	MP0000647_abnormal_sebaceous_gland	0.87286201
81	MP0002063_abnormal_learning/memory/cond	0.87193098
82	MP0004742_abnormal_vestibular_system	0.86470991
83	MP0000538_abnormal_urinary_bladder	0.85676428
84	MP0005195_abnormal_posterior_eye	0.85200480
85	MP0001970_abnormal_pain_threshold	0.84783410
86	MP0005085_abnormal_gallbladder_physiolo	0.84117363
87	MP0003121_genomic_imprinting	0.83100018
88	MP0002229_neurodegeneration	0.81636338
89	MP0003868_abnormal_feces_composition	0.81410286
90	MP0002009_preneoplasia	0.81332962
91	MP0004885_abnormal_endolymph	0.79774409
92	MP0004134_abnormal_chest_morphology	0.76778627
93	MP0002751_abnormal_autonomic_nervous	0.74955705
94	MP0002160_abnormal_reproductive_system	0.74027246
95	MP0000230_abnormal_systemic_arterial	0.73689721
96	MP0002075_abnormal_coat/hair_pigmentati	0.73025757
97	MP0001324_abnormal_eye_pigmentation	0.71978927
98	MP0005220_abnormal_exocrine_pancreas	0.71694505
99	MP0005266_abnormal_metabolism	0.71628368
100	MP0002734_abnormal_mechanical_nocicepti	0.71457166

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	4.96231187
2	Gaze-evoked nystagmus (HP:0000640)	4.52507972
3	Genetic anticipation (HP:0003743)	4.37452100
4	Pancreatic cysts (HP:0001737)	4.33668981
5	Progressive cerebellar ataxia (HP:0002073)	3.88240478
6	Pancreatic fibrosis (HP:0100732)	3.81942884
7	True hermaphroditism (HP:0010459)	3.62905112
8	Attenuation of retinal blood vessels (HP:0007843)	3.59106897
9	Abnormality of the renal cortex (HP:0011035)	3.44203966
10	Molar tooth sign on MRI (HP:0002419)	3.44181237
11	Abnormality of midbrain morphology (HP:0002418)	3.44181237
12	Fair hair (HP:0002286)	3.21021431
13	Protruding tongue (HP:0010808)	3.18537450
14	Chronic hepatic failure (HP:0100626)	3.12761384
15	Nephronophthisis (HP:0000090)	3.08123192
16	Febrile seizures (HP:0002373)	3.02190680
17	Absent speech (HP:0001344)	2.99854252
18	Abnormality of the renal medulla (HP:0100957)	2.95781532
19	Congenital stationary night blindness (HP:0007642)	2.94273916
20	Cystic liver disease (HP:0006706)	2.85631655
21	Clumsiness (HP:0002312)	2.81002787
22	Volvulus (HP:0002580)	2.80429491
23	Dialeptic seizures (HP:0011146)	2.67340003
24	Renal cortical cysts (HP:0000803)	2.66348887
25	Focal seizures (HP:0007359)	2.65241718
26	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.62200766
27	Congenital sensorineural hearing impairment (HP:0008527)	2.61802131
28	Abnormality of macular pigmentation (HP:0008002)	2.61127574
29	Type II lissencephaly (HP:0007260)	2.60885885
30	Medial flaring of the eyebrow (HP:0010747)	2.57652426
31	Absence seizures (HP:0002121)	2.56442307
32	Broad-based gait (HP:0002136)	2.54157253
33	Generalized hypopigmentation of hair (HP:0011358)	2.52178636
34	Bony spicule pigmentary retinopathy (HP:0007737)	2.51604239
35	Widely spaced teeth (HP:0000687)	2.50539186
36	Cerebellar dysplasia (HP:0007033)	2.45764017
37	Increased corneal curvature (HP:0100692)	2.45403380
38	Keratoconus (HP:0000563)	2.45403380
39	Tubular atrophy (HP:0000092)	2.41153212
40	Progressive inability to walk (HP:0002505)	2.38637622
41	Abolished electroretinogram (ERG) (HP:0000550)	2.32106839
42	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.27714910
43	Furrowed tongue (HP:0000221)	2.26581536
44	Inability to walk (HP:0002540)	2.26339157
45	Small hand (HP:0200055)	2.25328419
46	Focal motor seizures (HP:0011153)	2.22944925
47	Dysmetric saccades (HP:0000641)	2.22573966
48	Hypothermia (HP:0002045)	2.13226559
49	Chromsome breakage (HP:0040012)	2.11251997
50	Large for gestational age (HP:0001520)	2.09377963
51	Polydipsia (HP:0001959)	2.06713274
52	Abnormal drinking behavior (HP:0030082)	2.06713274
53	Congenital hepatic fibrosis (HP:0002612)	2.06398774
54	Abnormality of alanine metabolism (HP:0010916)	2.05866622
55	Hyperalaninemia (HP:0003348)	2.05866622
56	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.05866622
57	Stomach cancer (HP:0012126)	2.04553468
58	Constricted visual fields (HP:0001133)	2.04536169
59	Hypoplastic labia majora (HP:0000059)	2.03788269
60	Patellar aplasia (HP:0006443)	2.02095806
61	Hypoplastic ischia (HP:0003175)	2.02003785
62	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.01763418
63	Postaxial foot polydactyly (HP:0001830)	2.01346180
64	Abnormality of the ischium (HP:0003174)	2.00802075
65	Gait imbalance (HP:0002141)	2.00474947
66	Hypoplasia of the pons (HP:0012110)	1.99642128
67	Congenital primary aphakia (HP:0007707)	1.98407728
68	Central scotoma (HP:0000603)	1.96281129
69	Abnormality of the pons (HP:0007361)	1.96159250
70	Highly arched eyebrow (HP:0002553)	1.95394627
71	Sclerocornea (HP:0000647)	1.90863451
72	Hemiparesis (HP:0001269)	1.89877664
73	Pendular nystagmus (HP:0012043)	1.89855538
74	Abnormality of the labia majora (HP:0012881)	1.89322668
75	Atonic seizures (HP:0010819)	1.88234717
76	Abnormality of chromosome stability (HP:0003220)	1.87946537
77	Astigmatism (HP:0000483)	1.86917411
78	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.86194937
79	Short foot (HP:0001773)	1.86148639
80	Preaxial foot polydactyly (HP:0001841)	1.85554024
81	Decreased circulating renin level (HP:0003351)	1.84061009
82	Genital tract atresia (HP:0001827)	1.83422508
83	Thyroiditis (HP:0100646)	1.82993706
84	Aplasia/Hypoplasia of the patella (HP:0006498)	1.81385894
85	Sloping forehead (HP:0000340)	1.80670025
86	Intestinal atresia (HP:0011100)	1.80531419
87	Bile duct proliferation (HP:0001408)	1.80377171
88	Abnormal biliary tract physiology (HP:0012439)	1.80377171
89	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.80317363
90	Prostate neoplasm (HP:0100787)	1.80259349
91	Drooling (HP:0002307)	1.80191749
92	Birth length less than 3rd percentile (HP:0003561)	1.80175723
93	Oligodactyly (hands) (HP:0001180)	1.80137628
94	Clubbing of toes (HP:0100760)	1.79908312
95	Tented upper lip vermilion (HP:0010804)	1.79244707
96	Facial diplegia (HP:0001349)	1.78875478
97	Poor coordination (HP:0002370)	1.76240112
98	Anencephaly (HP:0002323)	1.75883064
99	Chorioretinal atrophy (HP:0000533)	1.74877487
100	Decreased central vision (HP:0007663)	1.74199781

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	9.70959958
2	BMPR1B	3.44240973
3	ACVR1B	3.33426880
4	ADRBK2	2.10235804
5	MKNK2	2.04575138
6	CASK	2.02208091
7	INSRR	1.85657182
8	NUAK1	1.80220482
9	STK38L	1.75879012
10	MAPK13	1.75849609
11	WNK3	1.68053573
12	GRK1	1.65690349
13	OXSR1	1.65622993
14	MAP4K2	1.59272608
15	AKT3	1.58874289
16	NTRK3	1.49513849
17	TAOK3	1.40447701
18	ZAK	1.39628268
19	STK39	1.34335898
20	MAP3K4	1.26530484
21	PINK1	1.26414598
22	TGFBR1	1.20914653
23	BRSK2	1.16005448
24	PAK3	1.08812813
25	TNIK	1.08725969
26	PNCK	1.05913186
27	LATS1	1.03666107
28	TEC	1.03419823
29	ADRBK1	1.01196951
30	STK3	1.00180275
31	MKNK1	0.98299628
32	FGFR2	0.97456874
33	KIT	0.90232734
34	PRKCE	0.85750881
35	PIK3CG	0.85326817
36	DAPK2	0.85322213
37	TRPM7	0.82753513
38	FER	0.81294356
39	BRD4	0.81092400
40	CAMKK2	0.80902505
41	WNK4	0.79199400
42	NLK	0.79140111
43	PIK3CA	0.76777922
44	PTK2B	0.76740232
45	MELK	0.75416040
46	SGK2	0.73949424
47	WEE1	0.73339523
48	STK38	0.73299527
49	PRKAA2	0.71785038
50	CAMK1G	0.69320519
51	MAP3K7	0.68294196
52	EIF2AK3	0.67703331
53	PRKCG	0.65548809
54	TXK	0.65235753
55	PLK2	0.63485262
56	MARK1	0.60844997
57	PRKAA1	0.56467668
58	ERBB3	0.55514893
59	CSNK1D	0.54819890
60	CAMK1D	0.54613995
61	TNK2	0.53352135
62	ATM	0.52988164
63	BCR	0.51637731
64	EPHA4	0.51204905
65	MAPKAPK5	0.50915575
66	STK11	0.48953081
67	IRAK1	0.48858539
68	CAMK2A	0.48649049
69	CHEK2	0.48003400
70	PKN1	0.47892685
71	TLK1	0.45542338
72	ATR	0.43764270
73	CDK3	0.43693133
74	OBSCN	0.42361594
75	CSNK1A1L	0.42013369
76	EPHA3	0.41311273
77	MAP2K6	0.41306042
78	WNK1	0.40443558
79	CSNK1G1	0.39789459
80	CDK12	0.38714576
81	MUSK	0.38547325
82	MAPKAPK3	0.38507627
83	SGK1	0.38498754
84	CCNB1	0.38023496
85	NEK2	0.37623689
86	PRKACB	0.36178155
87	ERBB2	0.35261040
88	MST4	0.35073471
89	EIF2AK2	0.34776070
90	IKBKB	0.33566162
91	CHUK	0.32705109
92	CAMK1	0.32425126
93	PRKG1	0.32365227
94	CSNK1G2	0.32205811
95	PRKACA	0.31990607
96	CAMK4	0.31628702
97	MAPK11	0.31600687
98	PLK3	0.28521341
99	CSNK1A1	0.28346309
100	PRKCB	0.27836202

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Butanoate metabolism_Homo sapiens_hsa00650	2.61509218
2	Phototransduction_Homo sapiens_hsa04744	2.44142201
3	Nicotine addiction_Homo sapiens_hsa05033	2.30112518
4	ABC transporters_Homo sapiens_hsa02010	2.28695413
5	Tryptophan metabolism_Homo sapiens_hsa00380	2.26939692
6	Homologous recombination_Homo sapiens_hsa03440	2.22195393
7	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.16950782
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.16629591
9	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.09572068
10	Fanconi anemia pathway_Homo sapiens_hsa03460	1.93082622
11	Linoleic acid metabolism_Homo sapiens_hsa00591	1.92343904
12	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.92193468
13	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.91425026
14	Selenocompound metabolism_Homo sapiens_hsa00450	1.91231908
15	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.82010098
16	Non-homologous end-joining_Homo sapiens_hsa03450	1.80133154
17	Taste transduction_Homo sapiens_hsa04742	1.76366852
18	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.73674347
19	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.70267932
20	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.68303663
21	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.64016685
22	Propanoate metabolism_Homo sapiens_hsa00640	1.59309654
23	Olfactory transduction_Homo sapiens_hsa04740	1.58472728
24	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.57927194
25	Lysine degradation_Homo sapiens_hsa00310	1.55949324
26	Morphine addiction_Homo sapiens_hsa05032	1.52267517
27	Ether lipid metabolism_Homo sapiens_hsa00565	1.51253976
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.46849939
29	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.45115135
30	Glutamatergic synapse_Homo sapiens_hsa04724	1.42784191
31	Circadian entrainment_Homo sapiens_hsa04713	1.34148280
32	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.34123273
33	Circadian rhythm_Homo sapiens_hsa04710	1.32351670
34	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.30443832
35	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.28786184
36	Salivary secretion_Homo sapiens_hsa04970	1.24616568
37	Insulin secretion_Homo sapiens_hsa04911	1.23802371
38	Histidine metabolism_Homo sapiens_hsa00340	1.23406026
39	Glycerolipid metabolism_Homo sapiens_hsa00561	1.20871685
40	Retinol metabolism_Homo sapiens_hsa00830	1.19928965
41	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.19335440
42	Calcium signaling pathway_Homo sapiens_hsa04020	1.19070191
43	Serotonergic synapse_Homo sapiens_hsa04726	1.15688548
44	GABAergic synapse_Homo sapiens_hsa04727	1.14968420
45	Basal transcription factors_Homo sapiens_hsa03022	1.08285855
46	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.05845579
47	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.02677010
48	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.01647844
49	RNA polymerase_Homo sapiens_hsa03020	0.99308318
50	Chemical carcinogenesis_Homo sapiens_hsa05204	0.98464606
51	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.97206511
52	beta-Alanine metabolism_Homo sapiens_hsa00410	0.95039778
53	Caffeine metabolism_Homo sapiens_hsa00232	0.90361383
54	One carbon pool by folate_Homo sapiens_hsa00670	0.89832699
55	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.87581688
56	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.83764000
57	Long-term depression_Homo sapiens_hsa04730	0.82156978
58	Dopaminergic synapse_Homo sapiens_hsa04728	0.78651785
59	Renin secretion_Homo sapiens_hsa04924	0.76375932
60	Cholinergic synapse_Homo sapiens_hsa04725	0.74164535
61	Gastric acid secretion_Homo sapiens_hsa04971	0.73582511
62	cAMP signaling pathway_Homo sapiens_hsa04024	0.73193982
63	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.72191482
64	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.71986985
65	Fatty acid degradation_Homo sapiens_hsa00071	0.71958125
66	Sphingolipid metabolism_Homo sapiens_hsa00600	0.71616332
67	Amphetamine addiction_Homo sapiens_hsa05031	0.70880129
68	Peroxisome_Homo sapiens_hsa04146	0.64861288
69	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.63265342
70	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.62932688
71	Cocaine addiction_Homo sapiens_hsa05030	0.62482178
72	RNA degradation_Homo sapiens_hsa03018	0.62306620
73	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.61468343
74	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.55792277
75	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.55430416
76	Protein export_Homo sapiens_hsa03060	0.55376798
77	Pancreatic secretion_Homo sapiens_hsa04972	0.51544317
78	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.51020183
79	Type II diabetes mellitus_Homo sapiens_hsa04930	0.50177329
80	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.48777384
81	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.48767840
82	Fatty acid metabolism_Homo sapiens_hsa01212	0.47865744
83	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.46641395
84	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.46303653
85	Regulation of autophagy_Homo sapiens_hsa04140	0.45878470
86	Purine metabolism_Homo sapiens_hsa00230	0.44351452
87	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.43850289
88	Melanoma_Homo sapiens_hsa05218	0.38801035
89	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.38592060
90	Mineral absorption_Homo sapiens_hsa04978	0.37415230
91	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.36109631
92	FoxO signaling pathway_Homo sapiens_hsa04068	0.33531042
93	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.32305831
94	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.32290732
95	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.31446190
96	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.29018082
97	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.28867243
98	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.27297010
99	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.25644974
100	Bile secretion_Homo sapiens_hsa04976	0.23505709

ZNF37A

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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