ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein K11-linked deubiquitination (GO:0035871)	4.88493761
2	tryptophan catabolic process (GO:0006569)	4.68442372
3	indole-containing compound catabolic process (GO:0042436)	4.68442372
4	indolalkylamine catabolic process (GO:0046218)	4.68442372
5	behavioral response to nicotine (GO:0035095)	4.35291215
6	kynurenine metabolic process (GO:0070189)	4.25310470
7	neural tube formation (GO:0001841)	4.24556821
8	indolalkylamine metabolic process (GO:0006586)	4.23883625
9	tryptophan metabolic process (GO:0006568)	4.01677037
10	monoubiquitinated protein deubiquitination (GO:0035520)	3.99604890
11	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.97819803
12	negative regulation of mast cell activation (GO:0033004)	3.86402798
13	cilium or flagellum-dependent cell motility (GO:0001539)	3.72008205
14	protein K48-linked deubiquitination (GO:0071108)	3.66876753
15	detection of light stimulus involved in visual perception (GO:0050908)	3.65238049
16	detection of light stimulus involved in sensory perception (GO:0050962)	3.65238049
17	interkinetic nuclear migration (GO:0022027)	3.63954001
18	fucose catabolic process (GO:0019317)	3.61249179
19	L-fucose metabolic process (GO:0042354)	3.61249179
20	L-fucose catabolic process (GO:0042355)	3.61249179
21	gamma-aminobutyric acid transport (GO:0015812)	3.43005396
22	establishment of protein localization to Golgi (GO:0072600)	3.39988203
23	signal peptide processing (GO:0006465)	3.33903070
24	reflex (GO:0060004)	3.31130755
25	regulation of hippo signaling (GO:0035330)	3.27852469
26	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.27373506
27	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.27373506
28	regulation of translation, ncRNA-mediated (GO:0045974)	3.27373506
29	sulfation (GO:0051923)	3.24944549
30	indole-containing compound metabolic process (GO:0042430)	3.24095642
31	regulation of establishment of cell polarity (GO:2000114)	3.21750260
32	protein K63-linked deubiquitination (GO:0070536)	3.14300622
33	cellular ketone body metabolic process (GO:0046950)	3.04516916
34	phospholipid translocation (GO:0045332)	3.00345636
35	lipid translocation (GO:0034204)	3.00345636
36	DNA double-strand break processing (GO:0000729)	2.96779421
37	response to pheromone (GO:0019236)	2.95765541
38	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.95627567
39	photoreceptor cell maintenance (GO:0045494)	2.95579299
40	cellular response to sterol (GO:0036315)	2.94328080
41	serotonin metabolic process (GO:0042428)	2.88250762
42	cytoplasmic mRNA processing body assembly (GO:0033962)	2.86013618
43	activated T cell proliferation (GO:0050798)	2.85719779
44	neuronal action potential (GO:0019228)	2.83194683
45	rRNA catabolic process (GO:0016075)	2.81831631
46	positive regulation of developmental pigmentation (GO:0048087)	2.80277650
47	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.79706562
48	central nervous system neuron axonogenesis (GO:0021955)	2.79704689
49	retinal cone cell development (GO:0046549)	2.79002873
50	regulation of sarcomere organization (GO:0060297)	2.77156864
51	neuronal action potential propagation (GO:0019227)	2.76704177
52	sex differentiation (GO:0007548)	2.76025861
53	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.75632917
54	ketone body metabolic process (GO:1902224)	2.75388704
55	primary amino compound metabolic process (GO:1901160)	2.75156388
56	regulation of establishment or maintenance of cell polarity (GO:0032878)	2.74088054
57	startle response (GO:0001964)	2.73586668
58	NAD biosynthetic process (GO:0009435)	2.73365580
59	negative regulation of sodium ion transport (GO:0010766)	2.73072986
60	membrane depolarization during action potential (GO:0086010)	2.72130465
61	auditory receptor cell stereocilium organization (GO:0060088)	2.71740790
62	cerebellar Purkinje cell differentiation (GO:0021702)	2.71432163
63	thyroid hormone metabolic process (GO:0042403)	2.71197445
64	snRNA transcription (GO:0009301)	2.69782545
65	amine catabolic process (GO:0009310)	2.68754098
66	cellular biogenic amine catabolic process (GO:0042402)	2.68754098
67	axoneme assembly (GO:0035082)	2.67680251
68	histone H3-K9 methylation (GO:0051567)	2.67548437
69	central nervous system projection neuron axonogenesis (GO:0021952)	2.67350237
70	replication fork processing (GO:0031297)	2.67282031
71	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.66889497
72	regulation of action potential (GO:0098900)	2.65956204
73	tachykinin receptor signaling pathway (GO:0007217)	2.64784330
74	behavioral response to ethanol (GO:0048149)	2.63035624
75	regulation of pigment cell differentiation (GO:0050932)	2.61639489
76	cAMP catabolic process (GO:0006198)	2.60843679
77	regulation of gene silencing by RNA (GO:0060966)	2.60797484
78	regulation of posttranscriptional gene silencing (GO:0060147)	2.60797484
79	regulation of gene silencing by miRNA (GO:0060964)	2.60797484
80	benzene-containing compound metabolic process (GO:0042537)	2.60477245
81	reciprocal meiotic recombination (GO:0007131)	2.59768582
82	reciprocal DNA recombination (GO:0035825)	2.59768582
83	adaptation of signaling pathway (GO:0023058)	2.57392306
84	regulation of memory T cell differentiation (GO:0043380)	2.56602584
85	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.53185445
86	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	2.51855619
87	inner ear receptor stereocilium organization (GO:0060122)	2.50557555
88	regulation of MHC class I biosynthetic process (GO:0045343)	2.50043627
89	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.48587741
90	kidney morphogenesis (GO:0060993)	2.48524803
91	spinal cord motor neuron differentiation (GO:0021522)	2.48376204
92	interferon-gamma production (GO:0032609)	2.48323238
93	proline transport (GO:0015824)	2.47492989
94	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.47406985
95	transmission of nerve impulse (GO:0019226)	2.46837657
96	histone H3-K4 trimethylation (GO:0080182)	2.45809464
97	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.45610650
98	negative regulation of multicellular organism growth (GO:0040015)	2.44256395
99	protein localization to cilium (GO:0061512)	2.44226407
100	oxidative demethylation (GO:0070989)	2.42760393

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.52162442
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.22553716
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.04349868
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.01275528
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.79587961
6	VDR_22108803_ChIP-Seq_LS180_Human	2.77069080
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.76663463
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.64902416
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.57120403
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.51100188
11	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.39235308
12	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.32111610
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.28133288
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.19430056
15	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.17176828
16	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.06778866
17	FUS_26573619_Chip-Seq_HEK293_Human	2.02815407
18	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.00117239
19	P300_19829295_ChIP-Seq_ESCs_Human	1.96885545
20	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.94623216
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.93639623
22	EWS_26573619_Chip-Seq_HEK293_Human	1.92572206
23	STAT3_23295773_ChIP-Seq_U87_Human	1.89675565
24	AR_21572438_ChIP-Seq_LNCaP_Human	1.89362881
25	SMAD4_21799915_ChIP-Seq_A2780_Human	1.76967389
26	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.76879063
27	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.75934764
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.72483006
29	TCF4_23295773_ChIP-Seq_U87_Human	1.68169205
30	BCAT_22108803_ChIP-Seq_LS180_Human	1.64058510
31	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.63832179
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.63061136
33	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.58514978
34	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.58060794
35	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.54956689
36	CBP_20019798_ChIP-Seq_JUKART_Human	1.54956689
37	AR_25329375_ChIP-Seq_VCAP_Human	1.53173143
38	DROSHA_22980978_ChIP-Seq_HELA_Human	1.53159009
39	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.52164929
40	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.52164929
41	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.48527923
42	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.47270216
43	REST_21632747_ChIP-Seq_MESCs_Mouse	1.44333234
44	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.43272563
45	TP53_16413492_ChIP-PET_HCT116_Human	1.40823998
46	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.36806393
47	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.34691218
48	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.34007315
49	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.33407719
50	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.33134738
51	RUNX2_22187159_ChIP-Seq_PCA_Human	1.33030137
52	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.32195739
53	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.32064656
54	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.30606261
55	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.29695281
56	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.28462575
57	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.28401541
58	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.28375439
59	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.27646130
60	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.26281578
61	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.26274061
62	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.26160053
63	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.26095097
64	TCF4_22108803_ChIP-Seq_LS180_Human	1.25769789
65	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.25743297
66	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.25624671
67	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.25244500
68	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.18648828
69	RNF2_27304074_Chip-Seq_NSC_Mouse	1.17546311
70	TP53_22573176_ChIP-Seq_HFKS_Human	1.17511545
71	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.16670396
72	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.15488237
73	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.13614071
74	P53_22387025_ChIP-Seq_ESCs_Mouse	1.12064672
75	IRF1_19129219_ChIP-ChIP_H3396_Human	1.11351417
76	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.11289658
77	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.10967674
78	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.10780867
79	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.10486080
80	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.09927296
81	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08622143
82	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.08328653
83	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.07120456
84	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.06942540
85	KDM2B_26808549_Chip-Seq_REH_Human	1.06623266
86	SOX2_19829295_ChIP-Seq_ESCs_Human	1.04973755
87	NANOG_19829295_ChIP-Seq_ESCs_Human	1.04973755
88	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.04212653
89	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.02990947
90	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.01824194
91	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.01210681
92	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.99860720
93	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.99572116
94	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.97550155
95	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.97031778
96	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.95774611
97	AHR_22903824_ChIP-Seq_MCF-7_Human	0.95743343
98	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.95720203
99	RXR_22108803_ChIP-Seq_LS180_Human	0.95633171
100	CDX2_22108803_ChIP-Seq_LS180_Human	0.95294160

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	5.40041744
2	MP0003787_abnormal_imprinting	2.87259419
3	MP0008057_abnormal_DNA_replication	2.81429608
4	MP0008877_abnormal_DNA_methylation	2.69736024
5	MP0005551_abnormal_eye_electrophysiolog	2.61377419
6	MP0009046_muscle_twitch	2.42309517
7	MP0003195_calcinosis	2.33227454
8	MP0001968_abnormal_touch/_nociception	2.27022193
9	MP0009745_abnormal_behavioral_response	2.19559089
10	MP0005174_abnormal_tail_pigmentation	2.14677858
11	MP0001501_abnormal_sleep_pattern	2.12054158
12	MP0002837_dystrophic_cardiac_calcinosis	2.06411191
13	MP0003646_muscle_fatigue	2.02851469
14	MP0001986_abnormal_taste_sensitivity	2.02471222
15	MP0004043_abnormal_pH_regulation	1.97653146
16	MP0003880_abnormal_central_pattern	1.93736631
17	MP0001486_abnormal_startle_reflex	1.90508352
18	MP0002736_abnormal_nociception_after	1.74890738
19	MP0002064_seizures	1.74534013
20	MP0000427_abnormal_hair_cycle	1.72186492
21	MP0002272_abnormal_nervous_system	1.70319369
22	MP0004885_abnormal_endolymph	1.67386635
23	MP0004142_abnormal_muscle_tone	1.64043639
24	MP0005646_abnormal_pituitary_gland	1.62910700
25	MP0005253_abnormal_eye_physiology	1.62562940
26	MP0003635_abnormal_synaptic_transmissio	1.62415913
27	MP0006292_abnormal_olfactory_placode	1.62355485
28	MP0006276_abnormal_autonomic_nervous	1.61471149
29	MP0002102_abnormal_ear_morphology	1.56032994
30	MP0002572_abnormal_emotion/affect_behav	1.53978688
31	MP0001485_abnormal_pinna_reflex	1.51524380
32	MP0002735_abnormal_chemical_nociception	1.51414235
33	MP0002638_abnormal_pupillary_reflex	1.48317411
34	MP0004924_abnormal_behavior	1.47774289
35	MP0005386_behavior/neurological_phenoty	1.47774289
36	MP0002876_abnormal_thyroid_physiology	1.47098319
37	MP0006072_abnormal_retinal_apoptosis	1.45744645
38	MP0008872_abnormal_physiological_respon	1.44049771
39	MP0000631_abnormal_neuroendocrine_gland	1.43591035
40	MP0005645_abnormal_hypothalamus_physiol	1.40961008
41	MP0002063_abnormal_learning/memory/cond	1.40059115
42	MP0005310_abnormal_salivary_gland	1.39901413
43	MP0002067_abnormal_sensory_capabilities	1.35692198
44	MP0000778_abnormal_nervous_system	1.32149062
45	MP0001984_abnormal_olfaction	1.30055698
46	MP0002928_abnormal_bile_duct	1.28576425
47	MP0004742_abnormal_vestibular_system	1.27276682
48	MP0002557_abnormal_social/conspecific_i	1.24259985
49	MP0002938_white_spotting	1.22226586
50	MP0004130_abnormal_muscle_cell	1.21701570
51	MP0004145_abnormal_muscle_electrophysio	1.20804881
52	MP0001970_abnormal_pain_threshold	1.20761561
53	MP0003252_abnormal_bile_duct	1.20091735
54	MP0002138_abnormal_hepatobiliary_system	1.19890666
55	MP0004147_increased_porphyrin_level	1.18272212
56	MP0000383_abnormal_hair_follicle	1.17841752
57	MP0000372_irregular_coat_pigmentation	1.16941416
58	MP0002009_preneoplasia	1.15683092
59	MP0000371_diluted_coat_color	1.15111537
60	MP0002733_abnormal_thermal_nociception	1.14400177
61	MP0002095_abnormal_skin_pigmentation	1.10495672
62	MP0003121_genomic_imprinting	1.09248515
63	MP0003890_abnormal_embryonic-extraembry	1.06880436
64	MP0010386_abnormal_urinary_bladder	1.03667398
65	MP0005075_abnormal_melanosome_morpholog	1.02314894
66	MP0003045_fibrosis	1.01665418
67	MP0003136_yellow_coat_color	0.98980186
68	MP0005389_reproductive_system_phenotype	0.97858162
69	MP0005195_abnormal_posterior_eye	0.97243207
70	MP0002229_neurodegeneration	0.96609490
71	MP0001919_abnormal_reproductive_system	0.94068781
72	MP0003633_abnormal_nervous_system	0.93184975
73	MP0002882_abnormal_neuron_morphology	0.91228495
74	MP0002163_abnormal_gland_morphology	0.90978830
75	MP0002234_abnormal_pharynx_morphology	0.90365314
76	MP0002752_abnormal_somatic_nervous	0.89127829
77	MP0000955_abnormal_spinal_cord	0.88499417
78	MP0008875_abnormal_xenobiotic_pharmacok	0.87846191
79	MP0002653_abnormal_ependyma_morphology	0.85622648
80	MP0003183_abnormal_peptide_metabolism	0.84573342
81	MP0004859_abnormal_synaptic_plasticity	0.83665648
82	MP0003943_abnormal_hepatobiliary_system	0.83656415
83	MP0005171_absent_coat_pigmentation	0.83337949
84	MP0002734_abnormal_mechanical_nocicepti	0.82206178
85	MP0005423_abnormal_somatic_nervous	0.81185036
86	MP0008961_abnormal_basal_metabolism	0.80937211
87	MP0001963_abnormal_hearing_physiology	0.80524749
88	MP0003698_abnormal_male_reproductive	0.79273743
89	MP0000015_abnormal_ear_pigmentation	0.78511521
90	MP0002184_abnormal_innervation	0.75927305
91	MP0003631_nervous_system_phenotype	0.75324673
92	MP0001440_abnormal_grooming_behavior	0.75080504
93	MP0002160_abnormal_reproductive_system	0.75052837
94	MP0002168_other_aberrant_phenotype	0.74605371
95	MP0000230_abnormal_systemic_arterial	0.71954475
96	MP0004215_abnormal_myocardial_fiber	0.67763308
97	MP0002693_abnormal_pancreas_physiology	0.67011267
98	MP0005266_abnormal_metabolism	0.66882518
99	MP0003137_abnormal_impulse_conducting	0.66510152
100	MP0001324_abnormal_eye_pigmentation	0.66113889

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Genetic anticipation (HP:0003743)	4.94508572
2	Progressive cerebellar ataxia (HP:0002073)	4.60873961
3	Hyperventilation (HP:0002883)	4.39236215
4	Gaze-evoked nystagmus (HP:0000640)	4.38819212
5	Pancreatic cysts (HP:0001737)	4.31516808
6	Pancreatic fibrosis (HP:0100732)	3.78058881
7	Congenital stationary night blindness (HP:0007642)	3.73143025
8	True hermaphroditism (HP:0010459)	3.62617526
9	Molar tooth sign on MRI (HP:0002419)	3.52085618
10	Abnormality of midbrain morphology (HP:0002418)	3.52085618
11	Febrile seizures (HP:0002373)	3.44537723
12	Nephronophthisis (HP:0000090)	3.39462186
13	Attenuation of retinal blood vessels (HP:0007843)	3.36378870
14	Chronic hepatic failure (HP:0100626)	3.22271626
15	Abnormality of the renal cortex (HP:0011035)	3.17770586
16	Protruding tongue (HP:0010808)	3.17757729
17	Abnormality of the renal medulla (HP:0100957)	3.08902781
18	Fair hair (HP:0002286)	2.97918059
19	Focal seizures (HP:0007359)	2.95430634
20	Cystic liver disease (HP:0006706)	2.84451396
21	Absent speech (HP:0001344)	2.76958258
22	Medial flaring of the eyebrow (HP:0010747)	2.66616418
23	Dialeptic seizures (HP:0011146)	2.65087295
24	Clumsiness (HP:0002312)	2.55012085
25	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.50660355
26	Broad-based gait (HP:0002136)	2.46059230
27	Focal motor seizures (HP:0011153)	2.45962393
28	Absence seizures (HP:0002121)	2.45383280
29	Bony spicule pigmentary retinopathy (HP:0007737)	2.40931239
30	Generalized hypopigmentation of hair (HP:0011358)	2.39470286
31	Abolished electroretinogram (ERG) (HP:0000550)	2.28061387
32	Increased corneal curvature (HP:0100692)	2.24812151
33	Keratoconus (HP:0000563)	2.24812151
34	Congenital sensorineural hearing impairment (HP:0008527)	2.24636839
35	Atonic seizures (HP:0010819)	2.23275274
36	Abnormal drinking behavior (HP:0030082)	2.17032638
37	Polydipsia (HP:0001959)	2.17032638
38	Decreased circulating renin level (HP:0003351)	2.16864737
39	Renal cortical cysts (HP:0000803)	2.16799701
40	Volvulus (HP:0002580)	2.16600095
41	Tubular atrophy (HP:0000092)	2.15677919
42	Gait imbalance (HP:0002141)	2.15546160
43	Congenital hepatic fibrosis (HP:0002612)	2.12325006
44	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.08733329
45	Inability to walk (HP:0002540)	2.07943245
46	Type II lissencephaly (HP:0007260)	2.07453740
47	Stomach cancer (HP:0012126)	2.07158888
48	Widely spaced teeth (HP:0000687)	2.07157725
49	Drooling (HP:0002307)	2.07059812
50	Patellar aplasia (HP:0006443)	2.05633682
51	Epileptic encephalopathy (HP:0200134)	2.05247789
52	Hemiparesis (HP:0001269)	2.04816183
53	Abnormal rod and cone electroretinograms (HP:0008323)	2.03750346
54	Bile duct proliferation (HP:0001408)	2.03403523
55	Abnormal biliary tract physiology (HP:0012439)	2.03403523
56	Pendular nystagmus (HP:0012043)	2.02042568
57	Congenital primary aphakia (HP:0007707)	2.01937731
58	Decreased central vision (HP:0007663)	2.00293313
59	Genital tract atresia (HP:0001827)	2.00115314
60	Tented upper lip vermilion (HP:0010804)	1.99926758
61	Postaxial foot polydactyly (HP:0001830)	1.94372226
62	Abnormality of alanine metabolism (HP:0010916)	1.91030326
63	Hyperalaninemia (HP:0003348)	1.91030326
64	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.91030326
65	Sclerocornea (HP:0000647)	1.90545140
66	Furrowed tongue (HP:0000221)	1.90402717
67	Excessive salivation (HP:0003781)	1.89391281
68	Impaired smooth pursuit (HP:0007772)	1.88879897
69	Aplasia/Hypoplasia of the patella (HP:0006498)	1.88123616
70	Vaginal atresia (HP:0000148)	1.87534094
71	Male pseudohermaphroditism (HP:0000037)	1.86693481
72	Hypoplasia of the pons (HP:0012110)	1.85905433
73	Thyroiditis (HP:0100646)	1.85084383
74	Highly arched eyebrow (HP:0002553)	1.84686880
75	Abnormality of the pons (HP:0007361)	1.84441212
76	Poor coordination (HP:0002370)	1.83176119
77	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.82983576
78	Progressive inability to walk (HP:0002505)	1.82307830
79	Intestinal atresia (HP:0011100)	1.82024451
80	Dysmetric saccades (HP:0000641)	1.80371484
81	Anencephaly (HP:0002323)	1.79921193
82	Nephrogenic diabetes insipidus (HP:0009806)	1.79481985
83	Urinary bladder sphincter dysfunction (HP:0002839)	1.79464179
84	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.79148453
85	Hypoproteinemia (HP:0003075)	1.78429377
86	Hemiplegia (HP:0002301)	1.77316390
87	Constricted visual fields (HP:0001133)	1.74084564
88	Small hand (HP:0200055)	1.73943051
89	Ectopic kidney (HP:0000086)	1.73070374
90	Lissencephaly (HP:0001339)	1.72693130
91	Short foot (HP:0001773)	1.72550868
92	Hypoplastic iliac wings (HP:0002866)	1.72228738
93	Hypoplastic ischia (HP:0003175)	1.71224331
94	Birth length less than 3rd percentile (HP:0003561)	1.70760611
95	Cerebellar dysplasia (HP:0007033)	1.70530875
96	Abnormality of the ischium (HP:0003174)	1.70272149
97	Abnormality of ocular smooth pursuit (HP:0000617)	1.69809170
98	Large for gestational age (HP:0001520)	1.68099987
99	Absent/shortened dynein arms (HP:0200106)	1.68012442
100	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.68012442

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	8.52241178
2	ACVR1B	2.96914938
3	BMPR1B	2.55471505
4	TAOK3	2.40961029
5	MAPK13	2.35909618
6	WNK3	2.27385786
7	ADRBK2	2.19207363
8	MAP4K2	1.98746858
9	GRK1	1.87788439
10	CASK	1.74798791
11	TXK	1.74099500
12	OXSR1	1.69588343
13	MAP3K4	1.64110617
14	ZAK	1.57440918
15	INSRR	1.55577782
16	NUAK1	1.53131998
17	PINK1	1.50396595
18	NTRK3	1.48073180
19	CAMKK2	1.44933753
20	MKNK2	1.41649072
21	MARK1	1.34166465
22	TNIK	1.21670484
23	SIK2	1.21171753
24	TEC	1.19396550
25	PIK3CA	1.16555078
26	AKT3	1.16421138
27	STK39	1.13958593
28	TNK2	1.11829157
29	DAPK2	1.10136843
30	WNK4	1.08341763
31	PAK3	1.05667999
32	EPHA4	1.01399846
33	ADRBK1	0.97513396
34	EPHA3	0.94356694
35	PIK3CG	0.92114299
36	FGFR2	0.91694592
37	TLK1	0.87710451
38	PKN1	0.86834821
39	SGK2	0.86562260
40	MAP3K7	0.84021741
41	NTRK2	0.79347043
42	CDK19	0.76708475
43	STK38L	0.75739379
44	ITK	0.73865193
45	TGFBR1	0.73248364
46	CAMK1	0.71480644
47	BCR	0.70284324
48	PTK2B	0.70172863
49	NLK	0.68168496
50	TRPM7	0.64697858
51	PRKCE	0.64410369
52	PLK2	0.63444635
53	PRKCG	0.63011367
54	STK11	0.62279596
55	ERBB2	0.61277350
56	CAMK4	0.60937128
57	ERBB3	0.60774824
58	KIT	0.60272382
59	BLK	0.59762197
60	CAMKK1	0.58812180
61	MKNK1	0.55801894
62	SYK	0.55691667
63	FER	0.55489126
64	MAP2K7	0.55013989
65	BTK	0.54512336
66	IRAK1	0.53289843
67	CSNK1D	0.53239060
68	PRKAA2	0.53201540
69	SGK494	0.53074215
70	SGK223	0.53074215
71	STK3	0.53053945
72	BRSK2	0.52928102
73	CDK3	0.52256765
74	PNCK	0.51532303
75	WNK1	0.50065465
76	TRIM28	0.49299490
77	CAMK2A	0.49189173
78	CAMK1G	0.48804323
79	MAPK11	0.45134176
80	ATR	0.44732879
81	SGK1	0.44554163
82	CAMK1D	0.41889040
83	MAP4K1	0.41517857
84	MAPKAPK5	0.40697150
85	IKBKB	0.40672310
86	DYRK2	0.40415245
87	BRD4	0.39246219
88	PRKCH	0.38663779
89	PRKAA1	0.38657444
90	DYRK1A	0.37669305
91	PRKCQ	0.37423052
92	CSNK1G2	0.36746740
93	FES	0.36179550
94	PRKCZ	0.35377585
95	PRKACA	0.35331953
96	STK38	0.34217856
97	MARK3	0.33549512
98	LCK	0.31724190
99	BMPR2	0.31591802
100	CHEK2	0.31484072

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	2.98708778
2	Phototransduction_Homo sapiens_hsa04744	2.69295672
3	Linoleic acid metabolism_Homo sapiens_hsa00591	2.39480886
4	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.36123961
5	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.35421833
6	Butanoate metabolism_Homo sapiens_hsa00650	2.19415443
7	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.17172383
8	Ether lipid metabolism_Homo sapiens_hsa00565	2.06151950
9	Nitrogen metabolism_Homo sapiens_hsa00910	2.06105867
10	Morphine addiction_Homo sapiens_hsa05032	1.98396064
11	ABC transporters_Homo sapiens_hsa02010	1.97309489
12	Taste transduction_Homo sapiens_hsa04742	1.92802480
13	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.90106660
14	Homologous recombination_Homo sapiens_hsa03440	1.80871760
15	Olfactory transduction_Homo sapiens_hsa04740	1.77662438
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.71141702
17	Tryptophan metabolism_Homo sapiens_hsa00380	1.71091972
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.69831416
19	Glutamatergic synapse_Homo sapiens_hsa04724	1.63662675
20	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.59871396
21	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.55251329
22	Circadian entrainment_Homo sapiens_hsa04713	1.53052916
23	Salivary secretion_Homo sapiens_hsa04970	1.45620463
24	GABAergic synapse_Homo sapiens_hsa04727	1.44317098
25	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.41816749
26	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.39956098
27	Insulin secretion_Homo sapiens_hsa04911	1.39389797
28	Lysine degradation_Homo sapiens_hsa00310	1.39114649
29	Serotonergic synapse_Homo sapiens_hsa04726	1.38300700
30	Calcium signaling pathway_Homo sapiens_hsa04020	1.36579496
31	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.35631100
32	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.34883356
33	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.33010710
34	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.19205338
35	Cholinergic synapse_Homo sapiens_hsa04725	1.16813161
36	Glycerolipid metabolism_Homo sapiens_hsa00561	1.15121701
37	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.11547568
38	Selenocompound metabolism_Homo sapiens_hsa00450	1.04332755
39	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.03930106
40	Primary immunodeficiency_Homo sapiens_hsa05340	1.01250463
41	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.00258144
42	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.00082588
43	Gastric acid secretion_Homo sapiens_hsa04971	0.96041862
44	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.92696610
45	cAMP signaling pathway_Homo sapiens_hsa04024	0.92000694
46	Long-term depression_Homo sapiens_hsa04730	0.87159962
47	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.87135248
48	Non-homologous end-joining_Homo sapiens_hsa03450	0.86148980
49	Propanoate metabolism_Homo sapiens_hsa00640	0.85101542
50	Basal transcription factors_Homo sapiens_hsa03022	0.85000985
51	Dopaminergic synapse_Homo sapiens_hsa04728	0.84468737
52	Caffeine metabolism_Homo sapiens_hsa00232	0.84287087
53	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.83700329
54	Histidine metabolism_Homo sapiens_hsa00340	0.82926226
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.82726131
56	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.81970732
57	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.81101055
58	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.80845193
59	Retinol metabolism_Homo sapiens_hsa00830	0.80790745
60	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.79870494
61	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.79258153
62	Amphetamine addiction_Homo sapiens_hsa05031	0.78731882
63	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.74497968
64	Regulation of autophagy_Homo sapiens_hsa04140	0.70285938
65	Renin secretion_Homo sapiens_hsa04924	0.68339351
66	Chemical carcinogenesis_Homo sapiens_hsa05204	0.67849759
67	Graft-versus-host disease_Homo sapiens_hsa05332	0.65003492
68	RNA polymerase_Homo sapiens_hsa03020	0.64079596
69	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.63738795
70	Circadian rhythm_Homo sapiens_hsa04710	0.61042839
71	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.60216063
72	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.58546145
73	Type II diabetes mellitus_Homo sapiens_hsa04930	0.58524412
74	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.57737947
75	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.57172166
76	Pancreatic secretion_Homo sapiens_hsa04972	0.55871596
77	RNA degradation_Homo sapiens_hsa03018	0.54432482
78	Cocaine addiction_Homo sapiens_hsa05030	0.54314691
79	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.53086644
80	Peroxisome_Homo sapiens_hsa04146	0.51394605
81	beta-Alanine metabolism_Homo sapiens_hsa00410	0.51190660
82	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.46733665
83	Asthma_Homo sapiens_hsa05310	0.46498889
84	Platelet activation_Homo sapiens_hsa04611	0.45948687
85	Ras signaling pathway_Homo sapiens_hsa04014	0.44976774
86	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.43522326
87	Choline metabolism in cancer_Homo sapiens_hsa05231	0.42759701
88	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.41259299
89	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.39299090
90	Type I diabetes mellitus_Homo sapiens_hsa04940	0.38760126
91	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.38017778
92	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.37850917
93	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.36781428
94	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.34692448
95	MAPK signaling pathway_Homo sapiens_hsa04010	0.33875746
96	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.33441266
97	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.32967088
98	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.30771189
99	Sphingolipid metabolism_Homo sapiens_hsa00600	0.30687745
100	One carbon pool by folate_Homo sapiens_hsa00670	0.30602739

ZNF37BP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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