ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	serotonin receptor signaling pathway (GO:0007210)	9.21540416
2	positive regulation of hair cycle (GO:0042635)	8.44445925
3	positive regulation of hair follicle development (GO:0051798)	8.44445925
4	positive regulation of osteoblast proliferation (GO:0033690)	8.37667063
5	negative regulation of interleukin-8 production (GO:0032717)	8.32433215
6	angiogenesis involved in wound healing (GO:0060055)	7.66459443
7	interferon-gamma production (GO:0032609)	7.40230778
8	regulation of appetite (GO:0032098)	7.26854031
9	regulation of Cdc42 GTPase activity (GO:0043088)	6.91849763
10	negative regulation of circadian rhythm (GO:0042754)	6.90709432
11	activated T cell proliferation (GO:0050798)	6.83277793
12	negative regulation of calcium ion transport into cytosol (GO:0010523)	6.73898055
13	protein K48-linked deubiquitination (GO:0071108)	6.17006835
14	glycoprotein catabolic process (GO:0006516)	6.10697599
15	protein K63-linked deubiquitination (GO:0070536)	5.98381157
16	hematopoietic stem cell proliferation (GO:0071425)	5.97166894
17	thyroid hormone metabolic process (GO:0042403)	5.93336913
18	carnitine metabolic process (GO:0009437)	5.88458466
19	cysteine metabolic process (GO:0006534)	5.83550100
20	glycerophospholipid catabolic process (GO:0046475)	5.83392693
21	lymphangiogenesis (GO:0001946)	5.70518117
22	regulation of hair follicle development (GO:0051797)	5.52250076
23	killing of cells of other organism (GO:0031640)	5.26407461
24	disruption of cells of other organism (GO:0044364)	5.26407461
25	carnitine transmembrane transport (GO:1902603)	5.17953346
26	sulfation (GO:0051923)	5.11202619
27	omega-hydroxylase P450 pathway (GO:0097267)	4.97083719
28	negative regulation of hormone biosynthetic process (GO:0032353)	4.95570539
29	granulocyte differentiation (GO:0030851)	4.92623500
30	carnitine transport (GO:0015879)	4.87605396
31	amino-acid betaine transport (GO:0015838)	4.87605396
32	mucosal immune response (GO:0002385)	4.76808920
33	amino-acid betaine metabolic process (GO:0006577)	4.65433981
34	filopodium assembly (GO:0046847)	4.60608164
35	lipid translocation (GO:0034204)	4.46796811
36	phospholipid translocation (GO:0045332)	4.46796811
37	paraxial mesoderm development (GO:0048339)	4.44089639
38	organ or tissue specific immune response (GO:0002251)	4.37287347
39	homocysteine metabolic process (GO:0050667)	4.31674687
40	negative regulation of hormone metabolic process (GO:0032351)	4.30672810
41	negative regulation of metanephros development (GO:0072217)	4.27829484
42	organic cation transport (GO:0015695)	4.21060046
43	defense response to fungus (GO:0050832)	4.17435958
44	regulation of steroid hormone biosynthetic process (GO:0090030)	3.98542610
45	heparan sulfate proteoglycan metabolic process (GO:0030201)	3.97703823
46	regulation of B cell receptor signaling pathway (GO:0050855)	3.88196919
47	positive regulation of cAMP-mediated signaling (GO:0043950)	3.87316405
48	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	3.86272307
49	positive regulation of epidermis development (GO:0045684)	3.83848992
50	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.79662499
51	protein sumoylation (GO:0016925)	3.76219354
52	flavonoid metabolic process (GO:0009812)	3.74125009
53	righting reflex (GO:0060013)	3.72211789
54	quaternary ammonium group transport (GO:0015697)	3.71953815
55	regulation of hair cycle (GO:0042634)	3.70347091
56	startle response (GO:0001964)	3.64061782
57	negative regulation by host of viral transcription (GO:0043922)	3.62394001
58	positive regulation of glycoprotein biosynthetic process (GO:0010560)	3.54826157
59	androgen biosynthetic process (GO:0006702)	3.54231584
60	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	3.48672031
61	cell killing (GO:0001906)	3.46281623
62	tryptophan catabolic process (GO:0006569)	3.43850769
63	indole-containing compound catabolic process (GO:0042436)	3.43850769
64	indolalkylamine catabolic process (GO:0046218)	3.43850769
65	regulation of establishment of cell polarity (GO:2000114)	3.42773393
66	regulation of osteoblast proliferation (GO:0033688)	3.38828315
67	sex differentiation (GO:0007548)	3.37958662
68	axon ensheathment in central nervous system (GO:0032291)	3.37196163
69	central nervous system myelination (GO:0022010)	3.37196163
70	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	3.35428180
71	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	3.35428180
72	rRNA catabolic process (GO:0016075)	3.33820281
73	regulation of sarcomere organization (GO:0060297)	3.33527554
74	spindle assembly involved in mitosis (GO:0090307)	3.28473053
75	regulation of glucocorticoid metabolic process (GO:0031943)	3.25360514
76	reflex (GO:0060004)	3.24458295
77	skin development (GO:0043588)	3.22034442
78	negative regulation of mast cell activation (GO:0033004)	3.21189137
79	DNA double-strand break processing (GO:0000729)	3.20322552
80	maturation of 5.8S rRNA (GO:0000460)	3.17696809
81	cilium or flagellum-dependent cell motility (GO:0001539)	3.17654067
82	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	3.17182274
83	protein-cofactor linkage (GO:0018065)	3.12817625
84	neuron fate determination (GO:0048664)	3.12418010
85	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	3.09395696
86	sex determination (GO:0007530)	3.03587598
87	endothelial cell proliferation (GO:0001935)	3.01791905
88	positive regulation of vasculogenesis (GO:2001214)	3.00516181
89	low-density lipoprotein particle remodeling (GO:0034374)	2.99355664
90	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	2.97444891
91	myoblast migration (GO:0051451)	2.96904680
92	dosage compensation (GO:0007549)	2.95037361
93	negative regulation of Ras GTPase activity (GO:0034261)	2.94631402
94	synaptic vesicle docking involved in exocytosis (GO:0016081)	2.94137707
95	positive regulation of blood coagulation (GO:0030194)	2.93741307
96	positive regulation of hemostasis (GO:1900048)	2.93741307
97	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.93182243
98	nuclear pore organization (GO:0006999)	2.92677580
99	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.92463721
100	protein K11-linked deubiquitination (GO:0035871)	15.2044971

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	6.33927991
2	IKZF1_21737484_ChIP-ChIP_HCT116_Human	4.98427980
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.28309436
4	SMAD_19615063_ChIP-ChIP_OVARY_Human	3.69846293
5	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.56436452
6	ESR1_20079471_ChIP-ChIP_T-47D_Human	3.31726287
7	TAF15_26573619_Chip-Seq_HEK293_Human	2.84104767
8	DROSHA_22980978_ChIP-Seq_HELA_Human	2.59697922
9	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.57463054
10	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.40174258
11	ER_23166858_ChIP-Seq_MCF-7_Human	2.34081625
12	AR_21572438_ChIP-Seq_LNCaP_Human	2.32764015
13	TP53_16413492_ChIP-PET_HCT116_Human	2.14042631
14	AR_25329375_ChIP-Seq_VCAP_Human	2.08369008
15	IGF1R_20145208_ChIP-Seq_DFB_Human	1.93119719
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.88936028
17	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.86812824
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.80913291
19	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.78784291
20	ZNF274_21170338_ChIP-Seq_K562_Hela	1.77374363
21	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.69273431
22	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.68140418
23	SMAD4_21799915_ChIP-Seq_A2780_Human	1.67193076
24	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.64259585
25	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.60899984
26	VDR_22108803_ChIP-Seq_LS180_Human	1.60690640
27	STAT3_23295773_ChIP-Seq_U87_Human	1.58749385
28	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.58389546
29	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.50592356
30	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.48959697
31	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.47858684
32	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.47698807
33	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.45627991
34	TP53_22573176_ChIP-Seq_HFKS_Human	1.42713397
35	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.41726756
36	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.41265132
37	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.40780603
38	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.39625571
39	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.39491329
40	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.37781508
41	EWS_26573619_Chip-Seq_HEK293_Human	1.37519830
42	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.35901206
43	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.33335501
44	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.32569107
45	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	1.30910380
46	P300_19829295_ChIP-Seq_ESCs_Human	1.30427141
47	TCF4_23295773_ChIP-Seq_U87_Human	1.27699744
48	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.26827929
49	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.25721290
50	CBP_20019798_ChIP-Seq_JUKART_Human	1.25721290
51	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.25341542
52	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.24813686
53	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.23387191
54	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.21719573
55	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.20386367
56	FUS_26573619_Chip-Seq_HEK293_Human	1.19757662
57	PHF8_20622853_ChIP-Seq_HELA_Human	1.18227336
58	TP53_18474530_ChIP-ChIP_U2OS_Human	1.17506963
59	RUNX2_22187159_ChIP-Seq_PCA_Human	1.17106402
60	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	1.14986471
61	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.14793690
62	CDX2_22108803_ChIP-Seq_LS180_Human	1.13942472
63	SOX3_22085726_ChIP-Seq_MUSCLE_Mouse	1.11787218
64	SPI1_23127762_ChIP-Seq_K562_Human	1.11364456
65	REST_21632747_ChIP-Seq_MESCs_Mouse	1.10732892
66	JUN_21703547_ChIP-Seq_K562_Human	1.10690720
67	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.06525669
68	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.05734491
69	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.05595579
70	TCF4_22108803_ChIP-Seq_LS180_Human	1.05227039
71	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.04404556
72	TBL1_22424771_ChIP-Seq_293T_Human	1.03335088
73	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.02907519
74	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.01739320
75	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.01190918
76	BCAT_22108803_ChIP-Seq_LS180_Human	1.00274462
77	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.98149339
78	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	0.97117868
79	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.95672104
80	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.95672104
81	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.95520840
82	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.93624777
83	AR_19668381_ChIP-Seq_PC3_Human	0.93521285
84	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.92331277
85	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.92039849
86	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.91683861
87	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.90857326
88	ERA_21632823_ChIP-Seq_H3396_Human	0.90373438
89	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.90307026
90	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.89890754
91	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	0.89798920
92	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.89747361
93	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.88010395
94	EZH2_22144423_ChIP-Seq_EOC_Human	0.87759518
95	RBPJ_21746931_ChIP-Seq_IB4_Human	0.86407930
96	ESET_19884257_ChIP-Seq_ESCs_Mouse	0.86142134
97	ERG_20517297_ChIP-Seq_VCAP_Human	0.86132095
98	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.85886842
99	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.85574075
100	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.85398353

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003183_abnormal_peptide_metabolism	7.79177629
2	MP0002138_abnormal_hepatobiliary_system	5.12340949
3	MP0005310_abnormal_salivary_gland	4.50066602
4	MP0003806_abnormal_nucleotide_metabolis	4.45497796
5	MP0005670_abnormal_white_adipose	4.22764876
6	MP0002139_abnormal_hepatobiliary_system	4.20175296
7	MP0002254_reproductive_system_inflammat	3.91873990
8	MP0008875_abnormal_xenobiotic_pharmacok	3.84295666
9	MP0000569_abnormal_digit_pigmentation	3.57087845
10	MP0001984_abnormal_olfaction	3.24084784
11	MP0004043_abnormal_pH_regulation	2.71993947
12	MP0005187_abnormal_penis_morphology	2.12149900
13	MP0001873_stomach_inflammation	2.11472608
14	MP0001919_abnormal_reproductive_system	2.09772501
15	MP0006082_CNS_inflammation	2.04942343
16	MP0000613_abnormal_salivary_gland	2.01109581
17	MP0005647_abnormal_sex_gland	1.80193958
18	MP0001348_abnormal_lacrimal_gland	1.72376182
19	MP0001879_abnormal_lymphatic_vessel	1.69916223
20	MP0005389_reproductive_system_phenotype	1.68170233
21	MP0002970_abnormal_white_adipose	1.65731298
22	MP0003315_abnormal_perineum_morphology	1.62646454
23	MP0002006_tumorigenesis	1.60186606
24	MP0002876_abnormal_thyroid_physiology	1.60047918
25	MP0005551_abnormal_eye_electrophysiolog	1.55751866
26	MP0002928_abnormal_bile_duct	1.54228500
27	MP0005084_abnormal_gallbladder_morpholo	1.48106530
28	MP0001986_abnormal_taste_sensitivity	1.48056455
29	MP0006054_spinal_hemorrhage	1.47588072
30	MP0009046_muscle_twitch	1.44899919
31	MP0002064_seizures	1.39326045
32	MP0006276_abnormal_autonomic_nervous	1.37708258
33	MP0009745_abnormal_behavioral_response	1.29160932
34	MP0003878_abnormal_ear_physiology	1.28991179
35	MP0005377_hearing/vestibular/ear_phenot	1.28991179
36	MP0000230_abnormal_systemic_arterial	1.25498512
37	MP0003724_increased_susceptibility_to	1.17477779
38	MP0001764_abnormal_homeostasis	1.10572459
39	MP0001905_abnormal_dopamine_level	1.09463426
40	MP0010329_abnormal_lipoprotein_level	1.08742184
41	MP0001346_abnormal_lacrimal_gland	1.03839464
42	MP0002269_muscular_atrophy	1.02197339
43	MP0002735_abnormal_chemical_nociception	1.02020497
44	MP0002234_abnormal_pharynx_morphology	0.99488204
45	MP0004858_abnormal_nervous_system	0.97816112
46	MP0002971_abnormal_brown_adipose	0.97727227
47	MP0002938_white_spotting	0.97308737
48	MP0005167_abnormal_blood-brain_barrier	0.96484023
49	MP0003787_abnormal_imprinting	0.96263740
50	MP0000647_abnormal_sebaceous_gland	0.93339517
51	MP0003638_abnormal_response/metabolism_	0.92288773
52	MP0002572_abnormal_emotion/affect_behav	0.91770182
53	MP0003045_fibrosis	0.90354140
54	MP0002277_abnormal_respiratory_mucosa	0.88000580
55	MP0008961_abnormal_basal_metabolism	0.86309497
56	MP0005174_abnormal_tail_pigmentation	0.86170503
57	MP0001486_abnormal_startle_reflex	0.85218339
58	MP0005360_urolithiasis	0.85207608
59	MP0000639_abnormal_adrenal_gland	0.85175780
60	MP0000427_abnormal_hair_cycle	0.82947459
61	MP0010234_abnormal_vibrissa_follicle	0.82658884
62	MP0003936_abnormal_reproductive_system	0.81720397
63	MP0003646_muscle_fatigue	0.80991618
64	MP0005452_abnormal_adipose_tissue	0.80349382
65	MP0004142_abnormal_muscle_tone	0.79565636
66	MP0005253_abnormal_eye_physiology	0.78240474
67	MP0003195_calcinosis	0.75903503
68	MP0008569_lethality_at_weaning	0.75347409
69	MP0010678_abnormal_skin_adnexa	0.75253684
70	MP0005332_abnormal_amino_acid	0.74965704
71	MP0000383_abnormal_hair_follicle	0.73018046
72	MP0001970_abnormal_pain_threshold	0.68891965
73	MP0001968_abnormal_touch/_nociception	0.68191645
74	MP0002163_abnormal_gland_morphology	0.67175082
75	MP0002127_abnormal_cardiovascular_syste	0.66775911
76	MP0002736_abnormal_nociception_after	0.66059715
77	MP0000685_abnormal_immune_system	0.65239057
78	MP0009643_abnormal_urine_homeostasis	0.62202947
79	MP0008995_early_reproductive_senescence	0.61113152
80	MP0003718_maternal_effect	0.60675910
81	MP0001270_distended_abdomen	0.58514549
82	MP0002118_abnormal_lipid_homeostasis	0.58154438
83	MP0009642_abnormal_blood_homeostasis	0.56749892
84	MP0005464_abnormal_platelet_physiology	0.55420911
85	MP0005410_abnormal_fertilization	0.55014599
86	MP0002090_abnormal_vision	0.54953839
87	MP0008877_abnormal_DNA_methylation	0.54890892
88	MP0002210_abnormal_sex_determination	0.54801199
89	MP0002272_abnormal_nervous_system	0.54578845
90	MP0005645_abnormal_hypothalamus_physiol	0.53933355
91	MP0002069_abnormal_eating/drinking_beha	0.53856582
92	MP0002557_abnormal_social/conspecific_i	0.52365593
93	MP0001440_abnormal_grooming_behavior	0.50111741
94	MP0002063_abnormal_learning/memory/cond	0.49571277
95	MP0002160_abnormal_reproductive_system	0.48107243
96	MP0003698_abnormal_male_reproductive	0.47846886
97	MP0003953_abnormal_hormone_level	0.47833695
98	MP0002909_abnormal_adrenal_gland	0.46510955
99	MP0005595_abnormal_vascular_smooth	0.46320628
100	MP0001663_abnormal_digestive_system	0.46274743

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital sensorineural hearing impairment (HP:0008527)	6.05186328
2	Lower limb hyperreflexia (HP:0002395)	5.90829868
3	Optic neuritis (HP:0100653)	5.75001705
4	Retrobulbar optic neuritis (HP:0100654)	5.75001705
5	Bilateral sensorineural hearing impairment (HP:0008619)	5.42862036
6	Abnormal pancreas size (HP:0012094)	5.42282775
7	Keratoconjunctivitis (HP:0001096)	5.20910285
8	Orchitis (HP:0100796)	4.98571269
9	Poikiloderma (HP:0001029)	4.51984468
10	Unilateral renal agenesis (HP:0000122)	4.49514625
11	Enlarged penis (HP:0000040)	4.45900999
12	Decreased circulating renin level (HP:0003351)	4.38419151
13	Hypoplasia of the uterus (HP:0000013)	4.02678154
14	Congenital stationary night blindness (HP:0007642)	3.99613642
15	Myositis (HP:0100614)	3.90836579
16	Gout (HP:0001997)	3.90429302
17	Abnormality of the pericardium (HP:0001697)	3.78424155
18	Keratoconjunctivitis sicca (HP:0001097)	3.69936491
19	Attenuation of retinal blood vessels (HP:0007843)	3.69813990
20	Abolished electroretinogram (ERG) (HP:0000550)	3.57049062
21	True hermaphroditism (HP:0010459)	3.35982556
22	Bony spicule pigmentary retinopathy (HP:0007737)	3.30472259
23	Late onset (HP:0003584)	3.27897674
24	Hyperventilation (HP:0002883)	3.26659646
25	Hyperglycinuria (HP:0003108)	3.21170714
26	Male pseudohermaphroditism (HP:0000037)	3.01407793
27	Aplasia/hypoplasia of the uterus (HP:0008684)	2.98877748
28	Xanthomatosis (HP:0000991)	2.94001393
29	Tinnitus (HP:0000360)	2.90720328
30	Absent speech (HP:0001344)	2.81180802
31	Gonadotropin excess (HP:0000837)	2.77115406
32	Pancreatic cysts (HP:0001737)	2.76293124
33	Abnormality of dental color (HP:0011073)	2.75786909
34	Abnormality of dentin (HP:0010299)	2.71594357
35	Bicornuate uterus (HP:0000813)	2.60804816
36	Abnormal drinking behavior (HP:0030082)	2.55340002
37	Polydipsia (HP:0001959)	2.55340002
38	Anorexia (HP:0002039)	2.52437076
39	Metaphyseal dysplasia (HP:0100255)	2.52170684
40	Keratitis (HP:0000491)	2.52120280
41	Pancreatic fibrosis (HP:0100732)	2.49488801
42	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.47502333
43	Breast carcinoma (HP:0003002)	2.44215400
44	Tongue fasciculations (HP:0001308)	2.40202495
45	Mesangial abnormality (HP:0001966)	2.38377373
46	Basal ganglia calcification (HP:0002135)	2.36930788
47	Germ cell neoplasia (HP:0100728)	2.35387903
48	Craniofacial hyperostosis (HP:0004493)	2.35167139
49	Acne (HP:0001061)	2.22652489
50	Amelogenesis imperfecta (HP:0000705)	2.21787122
51	Clumsiness (HP:0002312)	2.18699903
52	Large for gestational age (HP:0001520)	2.17563556
53	Hemoptysis (HP:0002105)	2.17386032
54	Preaxial foot polydactyly (HP:0001841)	2.16541682
55	Frequent falls (HP:0002359)	2.12450676
56	CNS demyelination (HP:0007305)	2.11979332
57	Spastic paraplegia (HP:0001258)	2.10893405
58	Pulmonary embolism (HP:0002204)	2.09248729
59	Spastic tetraparesis (HP:0001285)	2.09136743
60	Encephalitis (HP:0002383)	2.08844866
61	Ketoacidosis (HP:0001993)	2.08232462
62	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.06747084
63	Constricted visual fields (HP:0001133)	2.06521168
64	Muscle fibrillation (HP:0010546)	2.06380523
65	Bicuspid aortic valve (HP:0001647)	2.05006705
66	Anomalous pulmonary venous return (HP:0010772)	2.04980665
67	Abnormality of renin-angiotensin system (HP:0000847)	2.04854594
68	Abnormality of the dental pulp (HP:0006479)	2.04086870
69	Hyperkalemia (HP:0002153)	1.99918005
70	Retinal atrophy (HP:0001105)	1.99660655
71	Hyperaldosteronism (HP:0000859)	1.99608784
72	Arterial thrombosis (HP:0004420)	1.98396524
73	Delayed puberty (HP:0000823)	1.97812396
74	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.97492228
75	Glucose intolerance (HP:0000833)	1.94661985
76	Vertigo (HP:0002321)	1.94337680
77	Abnormality of glycine metabolism (HP:0010895)	1.90156916
78	Abnormality of serine family amino acid metabolism (HP:0010894)	1.90156916
79	Chronic hepatic failure (HP:0100626)	1.89742752
80	Paraplegia (HP:0010550)	1.88472397
81	Abnormal biliary tract physiology (HP:0012439)	1.87063431
82	Bile duct proliferation (HP:0001408)	1.87063431
83	Glomerulopathy (HP:0100820)	1.86494483
84	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.85302006
85	Heart block (HP:0012722)	1.84227338
86	Gangrene (HP:0100758)	1.84172919
87	Abnormality of the pupil (HP:0000615)	1.83291055
88	Tapered finger (HP:0001182)	1.82328010
89	Stomatitis (HP:0010280)	1.81027759
90	Hydroxyprolinuria (HP:0003080)	1.81027327
91	Abnormality of proline metabolism (HP:0010907)	1.81027327
92	Increased purine levels (HP:0004368)	1.80991522
93	Hyperuricemia (HP:0002149)	1.80991522
94	Subaortic stenosis (HP:0001682)	1.80681941
95	Abnormality of the left ventricular outflow tract (HP:0011103)	1.80681941
96	Abnormality of chloride homeostasis (HP:0011422)	1.79675054
97	Ileus (HP:0002595)	1.79132491
98	Type I diabetes mellitus (HP:0100651)	1.77914143
99	Neoplasm of the adrenal cortex (HP:0100641)	1.77889730
100	Stage 5 chronic kidney disease (HP:0003774)	1.77815784

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK3	6.60501606
2	TXK	5.11986372
3	PINK1	3.60151153
4	BLK	2.90566520
5	EEF2K	2.61805471
6	MAPKAPK3	2.21211760
7	YES1	2.14263929
8	ZAK	2.03755815
9	FRK	10.0837713
10	CDK12	1.88993233
11	ADRBK2	1.83857516
12	FER	1.81966431
13	GRK1	1.81722829
14	OXSR1	1.42065251
15	PRKCZ	1.37476872
16	IRAK1	1.25531612
17	WNK4	1.21992146
18	CSK	1.20239274
19	NEK9	1.18214987
20	MAPKAPK5	1.12836891
21	TRPM7	1.12335744
22	NTRK3	1.07649782
23	MKNK2	1.00118771
24	STK38L	0.97424678
25	NEK1	0.96234425
26	TAOK3	0.86893944
27	STK39	0.84817518
28	EIF2AK3	0.82764099
29	PIK3CA	0.81212900
30	PTK2B	0.79947278
31	MKNK1	0.77899662
32	STK24	0.74186620
33	MAPK13	0.72318283
34	TLK1	0.70452771
35	PRKD3	0.64894175
36	ADRBK1	0.60685680
37	CDK19	0.59129644
38	LIMK1	0.57879660
39	CHEK2	0.56576480
40	GRK7	0.56327077
41	PDK1	0.55781933
42	BCKDK	0.55019809
43	EIF2AK2	0.52674442
44	TIE1	0.52018752
45	MAP3K7	0.51084647
46	PLK4	0.50323980
47	CSF1R	0.50008711
48	PRKCH	0.49731898
49	IGF1R	0.49158186
50	PRKCA	0.48228862
51	PRKCB	0.46211906
52	PRKG1	0.45036314
53	RPS6KA4	0.43709852
54	PRKD2	0.41838650
55	RPS6KB2	0.41161077
56	PRKAA2	0.40628734
57	ERBB2	0.37409623
58	FGFR2	0.37145598
59	TEC	0.36482215
60	MAPK11	0.35686003
61	CASK	0.34880366
62	CAMK2A	0.33305823
63	PHKG2	0.32291940
64	PHKG1	0.32291940
65	CAMK1	0.31032101
66	MAPK10	0.30249920
67	NME1	0.29526447
68	INSRR	0.29222014
69	RPS6KA3	0.26660817
70	PRKACA	0.25626473
71	PRKCG	0.25514182
72	RPS6KA5	0.25486989
73	PRKCE	0.25112263
74	PRKCQ	0.25082208
75	MAP2K1	0.24939874
76	DAPK2	0.24803818
77	JAK1	0.24636494
78	PRKDC	0.23511565
79	PASK	0.22655735
80	LYN	0.22202786
81	ITK	0.21768783
82	FLT3	0.21684562
83	GSK3B	0.21611893
84	PDPK1	0.19885875
85	BTK	0.19864814
86	GSK3A	0.19732241
87	CSNK1A1	0.19722636
88	HIPK2	0.19164028
89	MAPK14	0.18929779
90	LMTK2	0.18817897
91	TTK	0.17238663
92	MUSK	0.16112581
93	ROCK1	0.15316331
94	PLK2	0.14074288
95	INSR	0.13952901
96	MAP4K1	0.13386554
97	OBSCN	0.13137582
98	BMPR2	0.12280491
99	RPS6KB1	0.11284262
100	CAMK1D	0.11273511

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosaminoglycan degradation_Homo sapiens_hsa00531	6.62584713
2	Selenocompound metabolism_Homo sapiens_hsa00450	3.80284360
3	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.55374113
4	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.78859949
5	Butanoate metabolism_Homo sapiens_hsa00650	2.60413853
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.35192679
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.34348012
8	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.30735082
9	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	2.23463357
10	Propanoate metabolism_Homo sapiens_hsa00640	2.18271948
11	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.17076991
12	Arachidonic acid metabolism_Homo sapiens_hsa00590	2.11256163
13	Ether lipid metabolism_Homo sapiens_hsa00565	2.07374804
14	Histidine metabolism_Homo sapiens_hsa00340	2.03356946
15	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.94563296
16	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.91893959
17	Nicotine addiction_Homo sapiens_hsa05033	1.90616393
18	Serotonergic synapse_Homo sapiens_hsa04726	1.84831883
19	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.71595288
20	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.66417507
21	Salivary secretion_Homo sapiens_hsa04970	1.65815408
22	Calcium signaling pathway_Homo sapiens_hsa04020	1.62048717
23	Glycerolipid metabolism_Homo sapiens_hsa00561	1.48236081
24	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.47197359
25	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.46748490
26	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.41985557
27	Fat digestion and absorption_Homo sapiens_hsa04975	1.39563295
28	Phototransduction_Homo sapiens_hsa04744	1.37025853
29	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.36757513
30	Proteasome_Homo sapiens_hsa03050	1.31882985
31	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.29132294
32	Tryptophan metabolism_Homo sapiens_hsa00380	1.26606088
33	Glutathione metabolism_Homo sapiens_hsa00480	1.25100712
34	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.22714670
35	Fatty acid degradation_Homo sapiens_hsa00071	1.20698839
36	Fatty acid metabolism_Homo sapiens_hsa01212	1.18118630
37	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.17918088
38	Olfactory transduction_Homo sapiens_hsa04740	1.17115144
39	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.15630081
40	ABC transporters_Homo sapiens_hsa02010	1.11122627
41	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.08940676
42	Lysine degradation_Homo sapiens_hsa00310	1.08427068
43	cAMP signaling pathway_Homo sapiens_hsa04024	1.06704083
44	Peroxisome_Homo sapiens_hsa04146	1.02384579
45	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.98339545
46	Morphine addiction_Homo sapiens_hsa05032	0.98069264
47	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.90458470
48	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.81400099
49	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.80878307
50	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.80560705
51	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.79669284
52	Cholinergic synapse_Homo sapiens_hsa04725	0.78048000
53	Homologous recombination_Homo sapiens_hsa03440	0.71036394
54	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.70332630
55	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.70231411
56	Fanconi anemia pathway_Homo sapiens_hsa03460	0.68738164
57	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.68513078
58	Non-homologous end-joining_Homo sapiens_hsa03450	0.65311219
59	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.60563957
60	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.56333014
61	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.54867056
62	Metabolic pathways_Homo sapiens_hsa01100	0.53501438
63	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.53484428
64	Nitrogen metabolism_Homo sapiens_hsa00910	0.52143478
65	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.51560153
66	RNA transport_Homo sapiens_hsa03013	0.50908246
67	GABAergic synapse_Homo sapiens_hsa04727	0.47742830
68	Pyruvate metabolism_Homo sapiens_hsa00620	0.46273436
69	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.45470103
70	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.45387986
71	Primary immunodeficiency_Homo sapiens_hsa05340	0.44948581
72	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.44524757
73	Gastric acid secretion_Homo sapiens_hsa04971	0.41724321
74	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.40802475
75	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.39867905
76	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.37880796
77	Insulin secretion_Homo sapiens_hsa04911	0.30933387
78	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.30087235
79	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.29417215
80	Pancreatic secretion_Homo sapiens_hsa04972	0.28772308
81	Platelet activation_Homo sapiens_hsa04611	0.27899851
82	PPAR signaling pathway_Homo sapiens_hsa03320	0.27802472
83	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.26863798
84	Chemical carcinogenesis_Homo sapiens_hsa05204	0.26752629
85	Taste transduction_Homo sapiens_hsa04742	0.22308304
86	Steroid biosynthesis_Homo sapiens_hsa00100	0.20449660
87	Arginine biosynthesis_Homo sapiens_hsa00220	0.19276359
88	Retinol metabolism_Homo sapiens_hsa00830	0.18497313
89	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.17666681
90	Base excision repair_Homo sapiens_hsa03410	0.15377391
91	Sphingolipid metabolism_Homo sapiens_hsa00600	0.14935277
92	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.14737358
93	Type II diabetes mellitus_Homo sapiens_hsa04930	0.12933268
94	RNA polymerase_Homo sapiens_hsa03020	0.12227185
95	Ras signaling pathway_Homo sapiens_hsa04014	0.11742073
96	Long-term depression_Homo sapiens_hsa04730	0.11726682
97	Huntingtons disease_Homo sapiens_hsa05016	0.11664769
98	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.11136857
99	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.10805087
100	AMPK signaling pathway_Homo sapiens_hsa04152	0.08982644

ZNF37CP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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