ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.43112003
2	pyrimidine nucleobase catabolic process (GO:0006208)	3.98083123
3	response to pheromone (GO:0019236)	3.90694512
4	gamma-aminobutyric acid transport (GO:0015812)	3.63155496
5	fucose catabolic process (GO:0019317)	3.59348678
6	L-fucose metabolic process (GO:0042354)	3.59348678
7	L-fucose catabolic process (GO:0042355)	3.59348678
8	detection of light stimulus involved in visual perception (GO:0050908)	3.50708847
9	detection of light stimulus involved in sensory perception (GO:0050962)	3.50708847
10	nucleobase catabolic process (GO:0046113)	3.40325305
11	neural tube formation (GO:0001841)	3.33486983
12	protein polyglutamylation (GO:0018095)	3.32629677
13	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.31168608
14	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.29557633
15	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.29249366
16	regulation of action potential (GO:0098900)	3.29188307
17	neuronal action potential propagation (GO:0019227)	3.27466008
18	neuronal action potential (GO:0019228)	3.27129918
19	kynurenine metabolic process (GO:0070189)	3.24675594
20	indolalkylamine metabolic process (GO:0006586)	3.24578805
21	tryptophan catabolic process (GO:0006569)	3.24186264
22	indole-containing compound catabolic process (GO:0042436)	3.24186264
23	indolalkylamine catabolic process (GO:0046218)	3.24186264
24	nonmotile primary cilium assembly (GO:0035058)	3.23016750
25	presynaptic membrane assembly (GO:0097105)	3.15615372
26	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.15247544
27	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.12204222
28	transmission of nerve impulse (GO:0019226)	3.05841824
29	membrane depolarization during action potential (GO:0086010)	3.04246062
30	postsynaptic membrane organization (GO:0001941)	3.03095115
31	epithelial cilium movement (GO:0003351)	3.02230507
32	protein localization to cilium (GO:0061512)	3.01103127
33	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.00521146
34	negative regulation of mast cell activation (GO:0033004)	2.95909991
35	presynaptic membrane organization (GO:0097090)	2.95778605
36	negative regulation of telomere maintenance (GO:0032205)	2.93733933
37	protein localization to synapse (GO:0035418)	2.91323284
38	cellular ketone body metabolic process (GO:0046950)	2.90843947
39	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.89748527
40	axoneme assembly (GO:0035082)	2.88089935
41	neuron cell-cell adhesion (GO:0007158)	2.85285289
42	establishment of protein localization to Golgi (GO:0072600)	2.83830170
43	primary amino compound metabolic process (GO:1901160)	2.82205039
44	auditory behavior (GO:0031223)	2.82157714
45	behavioral response to ethanol (GO:0048149)	2.80742081
46	tryptophan metabolic process (GO:0006568)	2.79338232
47	synaptic transmission, glutamatergic (GO:0035249)	2.76742183
48	cilium or flagellum-dependent cell motility (GO:0001539)	2.76296439
49	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.76162818
50	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.76162818
51	regulation of translation, ncRNA-mediated (GO:0045974)	2.76162818
52	positive regulation of action potential (GO:0045760)	2.75959075
53	glutamate receptor signaling pathway (GO:0007215)	2.75117885
54	synaptic transmission, cholinergic (GO:0007271)	2.72360440
55	startle response (GO:0001964)	2.72244457
56	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.71669760
57	kidney morphogenesis (GO:0060993)	2.71215939
58	serotonin metabolic process (GO:0042428)	2.70094401
59	indole-containing compound metabolic process (GO:0042430)	2.69939808
60	dendritic spine morphogenesis (GO:0060997)	2.69432703
61	cornea development in camera-type eye (GO:0061303)	2.69099583
62	cilium organization (GO:0044782)	2.68315264
63	cilium morphogenesis (GO:0060271)	2.68066810
64	reflex (GO:0060004)	2.66986926
65	somite development (GO:0061053)	2.66782424
66	DNA deamination (GO:0045006)	2.64946696
67	cilium assembly (GO:0042384)	2.63186416
68	regulation of cilium movement (GO:0003352)	2.62561294
69	retinal cone cell development (GO:0046549)	2.61785697
70	water-soluble vitamin biosynthetic process (GO:0042364)	2.61700450
71	tachykinin receptor signaling pathway (GO:0007217)	2.61537400
72	cilium movement (GO:0003341)	2.60398270
73	ketone body metabolic process (GO:1902224)	2.59670400
74	glycerophospholipid catabolic process (GO:0046475)	2.58055778
75	spinal cord motor neuron differentiation (GO:0021522)	2.56818584
76	piRNA metabolic process (GO:0034587)	2.56765538
77	regulation of telomere maintenance (GO:0032204)	2.56503345
78	protein K11-linked deubiquitination (GO:0035871)	2.54502512
79	sulfation (GO:0051923)	2.54440258
80	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.54257202
81	NADH dehydrogenase complex assembly (GO:0010257)	2.54257202
82	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.54257202
83	mechanosensory behavior (GO:0007638)	2.54200696
84	photoreceptor cell maintenance (GO:0045494)	2.53605062
85	inner ear receptor stereocilium organization (GO:0060122)	2.53518321
86	action potential (GO:0001508)	2.52834891
87	retinal ganglion cell axon guidance (GO:0031290)	2.51635588
88	platelet dense granule organization (GO:0060155)	2.49986745
89	proline transport (GO:0015824)	2.49134393
90	photoreceptor cell development (GO:0042461)	2.48899741
91	cAMP catabolic process (GO:0006198)	2.45803242
92	neuron-neuron synaptic transmission (GO:0007270)	2.44441760
93	regulation of hippo signaling (GO:0035330)	2.44226433
94	protein complex biogenesis (GO:0070271)	2.42121766
95	synapse assembly (GO:0007416)	2.40495226
96	neurotransmitter-gated ion channel clustering (GO:0072578)	2.40429936
97	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.39497454
98	vocalization behavior (GO:0071625)	2.37666375
99	protein targeting to Golgi (GO:0000042)	2.35973690
100	C4-dicarboxylate transport (GO:0015740)	2.34389476

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.01071608
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.41899958
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.40244528
4	VDR_22108803_ChIP-Seq_LS180_Human	3.16202275
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.74431877
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.64693061
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.63278565
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.45199196
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.41529261
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.37631306
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.36871983
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.16080090
13	FUS_26573619_Chip-Seq_HEK293_Human	2.08558174
14	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.06415542
15	P300_19829295_ChIP-Seq_ESCs_Human	2.04828456
16	EWS_26573619_Chip-Seq_HEK293_Human	2.04703148
17	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.00215177
18	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.94574020
19	REST_21632747_ChIP-Seq_MESCs_Mouse	1.86071669
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.83633660
21	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.80752648
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.74244082
23	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.69410495
24	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.69045241
25	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.68391891
26	SMAD4_21799915_ChIP-Seq_A2780_Human	1.65028881
27	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.63370754
28	STAT3_23295773_ChIP-Seq_U87_Human	1.63362981
29	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.62576223
30	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.60329892
31	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.60115886
32	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.60012891
33	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.59034090
34	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.54734014
35	CBP_20019798_ChIP-Seq_JUKART_Human	1.54734014
36	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.52298345
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.51719152
38	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.49828251
39	RNF2_27304074_Chip-Seq_NSC_Mouse	1.49109256
40	AR_25329375_ChIP-Seq_VCAP_Human	1.48650340
41	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.47772900
42	TCF4_23295773_ChIP-Seq_U87_Human	1.47701062
43	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.47098082
44	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.46882393
45	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.46882393
46	BCAT_22108803_ChIP-Seq_LS180_Human	1.46548534
47	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.44593369
48	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.43741251
49	IRF1_19129219_ChIP-ChIP_H3396_Human	1.43352066
50	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.42658784
51	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.41988729
52	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.41952204
53	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.41371906
54	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.39320265
55	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.38787806
56	AR_21572438_ChIP-Seq_LNCaP_Human	1.37046814
57	TP53_22573176_ChIP-Seq_HFKS_Human	1.35234745
58	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.33289755
59	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.31819999
60	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.31536918
61	RUNX2_22187159_ChIP-Seq_PCA_Human	1.29700663
62	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.28285328
63	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.28096178
64	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.27146554
65	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.25086549
66	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.24294854
67	DROSHA_22980978_ChIP-Seq_HELA_Human	1.21963537
68	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.20438116
69	TCF4_22108803_ChIP-Seq_LS180_Human	1.20256501
70	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.19058156
71	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.17987279
72	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.17627433
73	SOX2_19829295_ChIP-Seq_ESCs_Human	1.17060284
74	NANOG_19829295_ChIP-Seq_ESCs_Human	1.17060284
75	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.16230725
76	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.14668630
77	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.14200386
78	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.13974466
79	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.13128620
80	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.12715742
81	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.11177322
82	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.10552331
83	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.10447812
84	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.10316919
85	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.09343036
86	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.07329084
87	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.06937336
88	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.06576873
89	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.05122982
90	P53_22387025_ChIP-Seq_ESCs_Mouse	1.03691170
91	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.03563539
92	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.03563539
93	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.03471692
94	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.01834409
95	MYC_18940864_ChIP-ChIP_HL60_Human	1.01570861
96	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.01542440
97	NCOR_22424771_ChIP-Seq_293T_Human	1.01171547
98	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.00662808
99	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.00655335
100	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00647801

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	2.90827939
2	MP0003787_abnormal_imprinting	2.69170653
3	MP0008877_abnormal_DNA_methylation	2.59323471
4	MP0001968_abnormal_touch/_nociception	2.49160222
5	MP0002102_abnormal_ear_morphology	2.33785472
6	MP0009745_abnormal_behavioral_response	2.32730979
7	MP0000569_abnormal_digit_pigmentation	2.30651167
8	MP0005551_abnormal_eye_electrophysiolog	2.29943947
9	MP0009046_muscle_twitch	2.28744804
10	MP0006292_abnormal_olfactory_placode	2.23872984
11	MP0006276_abnormal_autonomic_nervous	2.11190592
12	MP0002272_abnormal_nervous_system	2.10893640
13	MP0003195_calcinosis	2.07667424
14	MP0005423_abnormal_somatic_nervous	2.01181928
15	MP0002837_dystrophic_cardiac_calcinosis	2.00944326
16	MP0002736_abnormal_nociception_after	1.99070674
17	MP0001486_abnormal_startle_reflex	1.95006417
18	MP0003635_abnormal_synaptic_transmissio	1.93565606
19	MP0005645_abnormal_hypothalamus_physiol	1.86603583
20	MP0002064_seizures	1.84305998
21	MP0002572_abnormal_emotion/affect_behav	1.82423348
22	MP0004885_abnormal_endolymph	1.80292956
23	MP0002735_abnormal_chemical_nociception	1.78518441
24	MP0004142_abnormal_muscle_tone	1.78502473
25	MP0004859_abnormal_synaptic_plasticity	1.77919302
26	MP0001984_abnormal_olfaction	1.76998792
27	MP0005646_abnormal_pituitary_gland	1.74558161
28	MP0002063_abnormal_learning/memory/cond	1.73358948
29	MP0001501_abnormal_sleep_pattern	1.73348367
30	MP0003646_muscle_fatigue	1.73002940
31	MP0000778_abnormal_nervous_system	1.71985752
32	MP0006072_abnormal_retinal_apoptosis	1.67633087
33	MP0001529_abnormal_vocalization	1.62792970
34	MP0000631_abnormal_neuroendocrine_gland	1.61651498
35	MP0004133_heterotaxia	1.57818846
36	MP0001986_abnormal_taste_sensitivity	1.57546929
37	MP0005253_abnormal_eye_physiology	1.57140573
38	MP0001485_abnormal_pinna_reflex	1.56545082
39	MP0002557_abnormal_social/conspecific_i	1.55317002
40	MP0001970_abnormal_pain_threshold	1.51600445
41	MP0002876_abnormal_thyroid_physiology	1.50838508
42	MP0002734_abnormal_mechanical_nocicepti	1.49730011
43	MP0002067_abnormal_sensory_capabilities	1.46792471
44	MP0010386_abnormal_urinary_bladder	1.46581761
45	MP0002638_abnormal_pupillary_reflex	1.46353102
46	MP0004043_abnormal_pH_regulation	1.46181545
47	MP0003136_yellow_coat_color	1.45686370
48	MP0004742_abnormal_vestibular_system	1.45473725
49	MP0003122_maternal_imprinting	1.45171509
50	MP0003121_genomic_imprinting	1.43299957
51	MP0004270_analgesia	1.42859764
52	MP0004924_abnormal_behavior	1.39619791
53	MP0005386_behavior/neurological_phenoty	1.39619791
54	MP0002733_abnormal_thermal_nociception	1.38842174
55	MP0000427_abnormal_hair_cycle	1.37707017
56	MP0008872_abnormal_physiological_respon	1.37379169
57	MP0002653_abnormal_ependyma_morphology	1.35429174
58	MP0002822_catalepsy	1.31957947
59	MP0002234_abnormal_pharynx_morphology	1.31791702
60	MP0004145_abnormal_muscle_electrophysio	1.28271848
61	MP0002928_abnormal_bile_duct	1.25294537
62	MP0002938_white_spotting	1.23127959
63	MP0002184_abnormal_innervation	1.21536584
64	MP0008875_abnormal_xenobiotic_pharmacok	1.17208248
65	MP0005084_abnormal_gallbladder_morpholo	1.16083830
66	MP0000955_abnormal_spinal_cord	1.15863159
67	MP0003011_delayed_dark_adaptation	1.11782476
68	MP0002163_abnormal_gland_morphology	1.11349123
69	MP0001188_hyperpigmentation	1.10059177
70	MP0002752_abnormal_somatic_nervous	1.09534068
71	MP0002882_abnormal_neuron_morphology	1.08407398
72	MP0000372_irregular_coat_pigmentation	1.05926399
73	MP0005187_abnormal_penis_morphology	1.00500200
74	MP0004147_increased_porphyrin_level	1.00326683
75	MP0003890_abnormal_embryonic-extraembry	0.97593075
76	MP0001905_abnormal_dopamine_level	0.97023471
77	MP0002909_abnormal_adrenal_gland	0.96466529
78	MP0005174_abnormal_tail_pigmentation	0.96215624
79	MP0008789_abnormal_olfactory_epithelium	0.96194234
80	MP0003137_abnormal_impulse_conducting	0.96160076
81	MP0005195_abnormal_posterior_eye	0.95812046
82	MP0002229_neurodegeneration	0.95767091
83	MP0002160_abnormal_reproductive_system	0.93625098
84	MP0005379_endocrine/exocrine_gland_phen	0.93236219
85	MP0003119_abnormal_digestive_system	0.92067287
86	MP0002751_abnormal_autonomic_nervous	0.91503630
87	MP0001440_abnormal_grooming_behavior	0.91364561
88	MP0004215_abnormal_myocardial_fiber	0.90969466
89	MP0000026_abnormal_inner_ear	0.90887033
90	MP0005389_reproductive_system_phenotype	0.90190948
91	MP0005499_abnormal_olfactory_system	0.89494466
92	MP0005394_taste/olfaction_phenotype	0.89494466
93	MP0001502_abnormal_circadian_rhythm	0.88356392
94	MP0001963_abnormal_hearing_physiology	0.86983669
95	MP0008995_early_reproductive_senescence	0.86189431
96	MP0003698_abnormal_male_reproductive	0.85995050
97	MP0004085_abnormal_heartbeat	0.83967366
98	MP0003633_abnormal_nervous_system	0.81274249
99	MP0002066_abnormal_motor_capabilities/c	0.79273221
100	MP0005410_abnormal_fertilization	0.79216136

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.24743350
2	Pancreatic fibrosis (HP:0100732)	3.97115182
3	Molar tooth sign on MRI (HP:0002419)	3.94149244
4	Abnormality of midbrain morphology (HP:0002418)	3.94149244
5	Nephronophthisis (HP:0000090)	3.84206130
6	True hermaphroditism (HP:0010459)	3.83317777
7	Hyperventilation (HP:0002883)	3.74518896
8	Congenital stationary night blindness (HP:0007642)	3.51845746
9	Abnormality of the renal medulla (HP:0100957)	3.34437459
10	Medial flaring of the eyebrow (HP:0010747)	3.31675198
11	Abnormality of the renal cortex (HP:0011035)	3.29568332
12	Progressive cerebellar ataxia (HP:0002073)	3.21708216
13	Genetic anticipation (HP:0003743)	3.09294427
14	Febrile seizures (HP:0002373)	3.04473419
15	Broad-based gait (HP:0002136)	2.99839853
16	Chronic hepatic failure (HP:0100626)	2.98058254
17	Type II lissencephaly (HP:0007260)	2.97864867
18	Gait imbalance (HP:0002141)	2.93971140
19	Gaze-evoked nystagmus (HP:0000640)	2.93707105
20	Focal motor seizures (HP:0011153)	2.81897603
21	Focal seizures (HP:0007359)	2.77624868
22	Cystic liver disease (HP:0006706)	2.76925145
23	Attenuation of retinal blood vessels (HP:0007843)	2.75979858
24	Protruding tongue (HP:0010808)	2.74164541
25	Congenital primary aphakia (HP:0007707)	2.72862011
26	Tubular atrophy (HP:0000092)	2.67200273
27	Lissencephaly (HP:0001339)	2.63484773
28	Renal cortical cysts (HP:0000803)	2.60096064
29	Abolished electroretinogram (ERG) (HP:0000550)	2.57989601
30	Nephrogenic diabetes insipidus (HP:0009806)	2.57986880
31	Atonic seizures (HP:0010819)	2.52651726
32	Inability to walk (HP:0002540)	2.47260037
33	Polydipsia (HP:0001959)	2.46263265
34	Abnormal drinking behavior (HP:0030082)	2.46263265
35	Genital tract atresia (HP:0001827)	2.45073490
36	Abnormal rod and cone electroretinograms (HP:0008323)	2.43456620
37	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.38970757
38	Pendular nystagmus (HP:0012043)	2.36778310
39	Vaginal atresia (HP:0000148)	2.36003046
40	Dialeptic seizures (HP:0011146)	2.35379465
41	Hemiparesis (HP:0001269)	2.32647215
42	Drooling (HP:0002307)	2.29499859
43	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.24897158
44	Sclerocornea (HP:0000647)	2.23815143
45	Hypothermia (HP:0002045)	2.23283731
46	Absent speech (HP:0001344)	2.22027634
47	Pachygyria (HP:0001302)	2.15705528
48	Absent/shortened dynein arms (HP:0200106)	2.15328897
49	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.15328897
50	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.13116650
51	Abnormality of the labia minora (HP:0012880)	2.10831171
52	Anencephaly (HP:0002323)	2.09899341
53	Progressive inability to walk (HP:0002505)	2.09808917
54	Congenital hepatic fibrosis (HP:0002612)	2.09257601
55	Cerebellar dysplasia (HP:0007033)	2.09090446
56	Keratoconus (HP:0000563)	2.09020399
57	Increased corneal curvature (HP:0100692)	2.09020399
58	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.07937027
59	Abnormality of alanine metabolism (HP:0010916)	2.07937027
60	Hyperalaninemia (HP:0003348)	2.07937027
61	Epileptic encephalopathy (HP:0200134)	2.05621823
62	Excessive salivation (HP:0003781)	2.05409410
63	Poor coordination (HP:0002370)	2.04359213
64	Bony spicule pigmentary retinopathy (HP:0007737)	2.03122806
65	Optic nerve hypoplasia (HP:0000609)	2.02339044
66	Absence seizures (HP:0002121)	1.99710842
67	Abnormal respiratory motile cilium morphology (HP:0005938)	1.97044814
68	Abnormal respiratory epithelium morphology (HP:0012253)	1.97044814
69	Polyuria (HP:0000103)	1.94093756
70	Furrowed tongue (HP:0000221)	1.93494964
71	Postaxial foot polydactyly (HP:0001830)	1.93453616
72	Patellar aplasia (HP:0006443)	1.92829916
73	Limb dystonia (HP:0002451)	1.92373952
74	Decreased circulating renin level (HP:0003351)	1.91933431
75	Polyphagia (HP:0002591)	1.90461024
76	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.87421121
77	Methylmalonic acidemia (HP:0002912)	1.86027683
78	Retinal dysplasia (HP:0007973)	1.85280802
79	Aplasia/Hypoplasia of the patella (HP:0006498)	1.85219822
80	Tubulointerstitial nephritis (HP:0001970)	1.85152209
81	Decreased central vision (HP:0007663)	1.83750560
82	Male pseudohermaphroditism (HP:0000037)	1.82649983
83	Postaxial hand polydactyly (HP:0001162)	1.82072742
84	Clumsiness (HP:0002312)	1.81522748
85	Large for gestational age (HP:0001520)	1.81345029
86	Bile duct proliferation (HP:0001408)	1.80737189
87	Abnormal biliary tract physiology (HP:0012439)	1.80737189
88	Fair hair (HP:0002286)	1.79971421
89	Specific learning disability (HP:0001328)	1.79573875
90	Tubulointerstitial abnormality (HP:0001969)	1.77424685
91	Thyroid-stimulating hormone excess (HP:0002925)	1.76945586
92	Agitation (HP:0000713)	1.76709377
93	Chorioretinal atrophy (HP:0000533)	1.75784155
94	Intestinal atresia (HP:0011100)	1.75635497
95	Concave nail (HP:0001598)	1.75266603
96	Abnormal ciliary motility (HP:0012262)	1.75087492
97	Stomach cancer (HP:0012126)	1.71436250
98	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.71241407
99	Narrow forehead (HP:0000341)	1.66702935
100	Tachypnea (HP:0002789)	1.65635449

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.79341942
2	CASK	3.28753025
3	WNK3	2.98094773
4	BMPR1B	2.78843345
5	MAP4K2	2.78602199
6	ADRBK2	2.63252467
7	MAP3K4	2.52512990
8	MARK1	2.48715409
9	MAPK13	2.22132845
10	PINK1	2.09837178
11	ZAK	1.93004517
12	WNK4	1.91114007
13	GRK1	1.91005738
14	ACVR1B	1.87862611
15	TNIK	1.78600674
16	MAP2K7	1.73970331
17	TLK1	1.73904172
18	NUAK1	1.73758271
19	INSRR	1.69988204
20	NTRK3	1.58162911
21	DAPK2	1.56421181
22	EPHA4	1.52216334
23	TAOK3	1.43822993
24	OXSR1	1.41574796
25	NTRK2	1.34117288
26	DYRK2	1.33749870
27	PAK3	1.33657323
28	BCR	1.32413209
29	SIK2	1.28601143
30	TRIM28	1.27798825
31	STK39	1.26704617
32	MKNK2	1.23036302
33	PNCK	1.17506542
34	PRKCG	1.10754423
35	TXK	1.08341321
36	EPHA3	1.03998088
37	PLK2	1.03645113
38	CSNK1G2	1.02018315
39	CAMKK2	1.01008785
40	PRKCE	0.98178141
41	ADRBK1	0.97128863
42	ERBB3	0.95585045
43	FGFR2	0.91934916
44	PHKG2	0.84388396
45	PHKG1	0.84388396
46	CSNK1A1L	0.78808941
47	CSNK1G1	0.77854349
48	MAP2K4	0.76710986
49	CSNK1G3	0.74604768
50	PKN1	0.73055608
51	CAMK2A	0.71609032
52	PLK4	0.70403786
53	CAMK1	0.69499795
54	TGFBR1	0.69483257
55	PIK3CA	0.69164767
56	BCKDK	0.67793515
57	CAMK1G	0.67247506
58	MINK1	0.65286563
59	PTK2B	0.64242310
60	AKT3	0.61858978
61	TIE1	0.60716779
62	STK38L	0.59410868
63	STK11	0.59224273
64	MAPK15	0.56356913
65	SGK223	0.54976476
66	SGK494	0.54976476
67	SGK2	0.52077435
68	MKNK1	0.51932556
69	PRKCQ	0.51919227
70	PRKCZ	0.51221252
71	PRKACA	0.51033129
72	OBSCN	0.50234427
73	VRK1	0.49849642
74	DYRK1A	0.49363187
75	CDK19	0.48907788
76	MAP2K6	0.48507325
77	CDK5	0.47564007
78	CSNK1A1	0.47219072
79	PAK6	0.46855092
80	CAMK1D	0.45997543
81	PRKAA1	0.45652034
82	DYRK3	0.45575043
83	MAPKAPK5	0.45562457
84	CSNK1D	0.45381904
85	RPS6KA5	0.45313707
86	CAMK4	0.45161612
87	MUSK	0.44089842
88	CAMKK1	0.41475647
89	PRKG1	0.39426287
90	FER	0.38586834
91	TEC	0.37761062
92	UHMK1	0.37234700
93	PRKCH	0.36009054
94	TYRO3	0.34855928
95	NLK	0.34509107
96	PRKACB	0.33941730
97	ITK	0.33328627
98	PRKCA	0.33262317
99	GRK7	0.33209715
100	FLT3	0.31401958

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.76191910
2	Phototransduction_Homo sapiens_hsa04744	3.05624747
3	Linoleic acid metabolism_Homo sapiens_hsa00591	2.31547023
4	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.30260983
5	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.28669997
6	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.23733928
7	Butanoate metabolism_Homo sapiens_hsa00650	2.15480150
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.15366730
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.14614457
10	Morphine addiction_Homo sapiens_hsa05032	2.07506283
11	Taste transduction_Homo sapiens_hsa04742	2.00385480
12	Nitrogen metabolism_Homo sapiens_hsa00910	1.91533845
13	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.90599197
14	GABAergic synapse_Homo sapiens_hsa04727	1.89546381
15	Glutamatergic synapse_Homo sapiens_hsa04724	1.86020284
16	Circadian entrainment_Homo sapiens_hsa04713	1.83203080
17	Oxidative phosphorylation_Homo sapiens_hsa00190	1.79002664
18	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.75745758
19	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.74399692
20	Ether lipid metabolism_Homo sapiens_hsa00565	1.67964752
21	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.65566361
22	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.64861338
23	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.62139365
24	Olfactory transduction_Homo sapiens_hsa04740	1.62058383
25	Selenocompound metabolism_Homo sapiens_hsa00450	1.59306203
26	Insulin secretion_Homo sapiens_hsa04911	1.55713005
27	Cardiac muscle contraction_Homo sapiens_hsa04260	1.51027934
28	Tryptophan metabolism_Homo sapiens_hsa00380	1.49593415
29	Serotonergic synapse_Homo sapiens_hsa04726	1.41482490
30	Caffeine metabolism_Homo sapiens_hsa00232	1.35502576
31	Parkinsons disease_Homo sapiens_hsa05012	1.32570828
32	Protein export_Homo sapiens_hsa03060	1.28551981
33	Dopaminergic synapse_Homo sapiens_hsa04728	1.28271186
34	Propanoate metabolism_Homo sapiens_hsa00640	1.24087189
35	Fanconi anemia pathway_Homo sapiens_hsa03460	1.23299924
36	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.22468284
37	Basal transcription factors_Homo sapiens_hsa03022	1.22236171
38	Salivary secretion_Homo sapiens_hsa04970	1.16384172
39	ABC transporters_Homo sapiens_hsa02010	1.14956736
40	RNA polymerase_Homo sapiens_hsa03020	1.11706371
41	Cocaine addiction_Homo sapiens_hsa05030	1.11137363
42	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.09090783
43	Homologous recombination_Homo sapiens_hsa03440	1.07581735
44	Amphetamine addiction_Homo sapiens_hsa05031	1.04406947
45	Regulation of autophagy_Homo sapiens_hsa04140	1.03519527
46	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.03212848
47	Calcium signaling pathway_Homo sapiens_hsa04020	1.02227485
48	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.01138608
49	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.00088675
50	Huntingtons disease_Homo sapiens_hsa05016	0.97993673
51	Cholinergic synapse_Homo sapiens_hsa04725	0.97966723
52	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.96733360
53	Peroxisome_Homo sapiens_hsa04146	0.96150766
54	RNA degradation_Homo sapiens_hsa03018	0.94329292
55	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.93293559
56	Long-term depression_Homo sapiens_hsa04730	0.88332814
57	Alzheimers disease_Homo sapiens_hsa05010	0.86048620
58	Collecting duct acid secretion_Homo sapiens_hsa04966	0.82928159
59	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.81971765
60	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.78730636
61	Chemical carcinogenesis_Homo sapiens_hsa05204	0.78003410
62	cAMP signaling pathway_Homo sapiens_hsa04024	0.74794035
63	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.71780510
64	Circadian rhythm_Homo sapiens_hsa04710	0.71238449
65	Retinol metabolism_Homo sapiens_hsa00830	0.71116249
66	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.70578403
67	Renin secretion_Homo sapiens_hsa04924	0.68854443
68	Gastric acid secretion_Homo sapiens_hsa04971	0.68357690
69	beta-Alanine metabolism_Homo sapiens_hsa00410	0.66939118
70	Glycerolipid metabolism_Homo sapiens_hsa00561	0.66431489
71	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.65609523
72	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.62087967
73	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.61677955
74	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.60273827
75	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.58512730
76	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.57184947
77	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.57151074
78	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.55733476
79	Axon guidance_Homo sapiens_hsa04360	0.55178910
80	Histidine metabolism_Homo sapiens_hsa00340	0.54973259
81	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.52013061
82	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.48480790
83	Type II diabetes mellitus_Homo sapiens_hsa04930	0.47411050
84	Purine metabolism_Homo sapiens_hsa00230	0.42229520
85	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.41984373
86	Metabolic pathways_Homo sapiens_hsa01100	0.41945611
87	Fat digestion and absorption_Homo sapiens_hsa04975	0.41045126
88	Steroid biosynthesis_Homo sapiens_hsa00100	0.38938910
89	Mineral absorption_Homo sapiens_hsa04978	0.38409469
90	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.35368488
91	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.34671657
92	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.34411222
93	One carbon pool by folate_Homo sapiens_hsa00670	0.33436062
94	Alcoholism_Homo sapiens_hsa05034	0.33392576
95	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.33167205
96	Pancreatic secretion_Homo sapiens_hsa04972	0.32912266
97	Lysine degradation_Homo sapiens_hsa00310	0.31668856
98	Ras signaling pathway_Homo sapiens_hsa04014	0.31460928
99	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.29260416
100	Basal cell carcinoma_Homo sapiens_hsa05217	0.29214741

ZNF382

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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