ZNF383

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a KRAB-related zinc finger protein that inhibits the transcription of some MAPK signaling pathway genes. The repressor activity resides in the KRAB domain of the encoded protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.31926656
2L-fucose catabolic process (GO:0042355)5.72849080
3fucose catabolic process (GO:0019317)5.72849080
4L-fucose metabolic process (GO:0042354)5.72849080
5indole-containing compound catabolic process (GO:0042436)4.04443126
6indolalkylamine catabolic process (GO:0046218)4.04443126
7tryptophan catabolic process (GO:0006569)4.04443126
8indolalkylamine metabolic process (GO:0006586)4.03792683
9DNA deamination (GO:0045006)4.00282731
10kynurenine metabolic process (GO:0070189)3.88414805
11prenylation (GO:0097354)3.86274610
12protein prenylation (GO:0018342)3.86274610
13detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.75547403
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.71674860
15response to pheromone (GO:0019236)3.67608487
16mitochondrial respiratory chain complex I assembly (GO:0032981)3.59434994
17NADH dehydrogenase complex assembly (GO:0010257)3.59434994
18mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.59434994
19tryptophan metabolic process (GO:0006568)3.53001834
20detection of light stimulus involved in sensory perception (GO:0050962)3.38136537
21detection of light stimulus involved in visual perception (GO:0050908)3.38136537
22oxidative demethylation (GO:0070989)3.37659787
23platelet dense granule organization (GO:0060155)3.20649539
24cellular ketone body metabolic process (GO:0046950)3.19778780
25negative regulation of telomere maintenance (GO:0032205)3.19250590
26nonmotile primary cilium assembly (GO:0035058)3.18991379
27neural tube formation (GO:0001841)3.12530274
28protein complex biogenesis (GO:0070271)3.12367569
29epithelial cilium movement (GO:0003351)3.06575963
30indole-containing compound metabolic process (GO:0042430)3.02375247
31negative regulation of mast cell activation (GO:0033004)3.00172056
32protein K11-linked deubiquitination (GO:0035871)2.98359382
33sulfation (GO:0051923)2.97879215
34piRNA metabolic process (GO:0034587)2.95151523
35behavioral response to ethanol (GO:0048149)2.94633413
36preassembly of GPI anchor in ER membrane (GO:0016254)2.91357166
37cornea development in camera-type eye (GO:0061303)2.89510818
38ketone body metabolic process (GO:1902224)2.88563295
39amine catabolic process (GO:0009310)2.87660625
40cellular biogenic amine catabolic process (GO:0042402)2.87660625
41fucosylation (GO:0036065)2.87518793
42mitochondrial respiratory chain complex assembly (GO:0033108)2.85645682
43axoneme assembly (GO:0035082)2.84934393
44negative regulation of translation, ncRNA-mediated (GO:0040033)2.83757067
45regulation of translation, ncRNA-mediated (GO:0045974)2.83757067
46negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.83757067
47cilium or flagellum-dependent cell motility (GO:0001539)2.83466612
48protein import into peroxisome matrix (GO:0016558)2.83066509
49multicellular organism reproduction (GO:0032504)2.79040016
50synaptic transmission, cholinergic (GO:0007271)2.77057897
51G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.76515421
52regulation of hippo signaling (GO:0035330)2.76488218
53neuronal action potential (GO:0019228)2.75859090
54DNA demethylation (GO:0080111)2.74325879
55kidney morphogenesis (GO:0060993)2.71111126
56regulation of action potential (GO:0098900)2.70159520
57cAMP catabolic process (GO:0006198)2.69004935
58water-soluble vitamin biosynthetic process (GO:0042364)2.66310638
59retinal cone cell development (GO:0046549)2.64298142
60regulation of rhodopsin mediated signaling pathway (GO:0022400)2.60251660
61double-strand break repair via homologous recombination (GO:0000724)2.58704463
62recombinational repair (GO:0000725)2.58534940
63primary amino compound metabolic process (GO:1901160)2.57438408
64rhodopsin mediated signaling pathway (GO:0016056)2.57056086
65nephron tubule morphogenesis (GO:0072078)2.56325471
66nephron epithelium morphogenesis (GO:0072088)2.56325471
67cilium movement (GO:0003341)2.56248911
68negative regulation of synaptic transmission, GABAergic (GO:0032229)2.55086876
69reflex (GO:0060004)2.55002382
70drug catabolic process (GO:0042737)2.54432556
71protein polyglutamylation (GO:0018095)2.53555817
72cellular response to ATP (GO:0071318)2.53236476
73gamma-aminobutyric acid transport (GO:0015812)2.52755677
74photoreceptor cell maintenance (GO:0045494)2.52240123
75NAD biosynthetic process (GO:0009435)2.50371141
76cilium morphogenesis (GO:0060271)2.49911855
77cilium organization (GO:0044782)2.49587286
78regulation of posttranscriptional gene silencing (GO:0060147)2.49307438
79regulation of gene silencing by miRNA (GO:0060964)2.49307438
80regulation of gene silencing by RNA (GO:0060966)2.49307438
81reciprocal meiotic recombination (GO:0007131)2.49144445
82reciprocal DNA recombination (GO:0035825)2.49144445
83photoreceptor cell development (GO:0042461)2.48968694
84phosphatidylinositol acyl-chain remodeling (GO:0036149)2.48625666
85regulation of nuclear cell cycle DNA replication (GO:0033262)2.45625687
86serotonin metabolic process (GO:0042428)2.45060117
87rRNA catabolic process (GO:0016075)2.44467899
88negative regulation of cytosolic calcium ion concentration (GO:0051481)2.44429821
89regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.43312981
90somite development (GO:0061053)2.42686034
91auditory receptor cell stereocilium organization (GO:0060088)2.42382178
92cilium assembly (GO:0042384)2.41076881
93ubiquinone biosynthetic process (GO:0006744)2.40578177
94regulation of cilium movement (GO:0003352)2.40417771
95positive regulation of fatty acid transport (GO:2000193)2.40330585
96regulation of sarcomere organization (GO:0060297)2.40198436
97negative regulation of reactive oxygen species metabolic process (GO:2000378)2.39524342
98membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.39521394
99inner ear receptor stereocilium organization (GO:0060122)2.38877130
100cyclic nucleotide catabolic process (GO:0009214)2.38763120

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.91934625
2ZNF274_21170338_ChIP-Seq_K562_Hela3.83449173
3EZH2_22144423_ChIP-Seq_EOC_Human2.94693701
4GBX2_23144817_ChIP-Seq_PC3_Human2.92870140
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.79072644
6IGF1R_20145208_ChIP-Seq_DFB_Human2.55957071
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.52776603
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.35903135
9EWS_26573619_Chip-Seq_HEK293_Human2.21758132
10FUS_26573619_Chip-Seq_HEK293_Human2.20771343
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.20122504
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.18627610
13TAF15_26573619_Chip-Seq_HEK293_Human2.12861204
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.08889425
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06094114
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.02186600
17* NOTCH1_21737748_ChIP-Seq_TLL_Human1.92640609
18P300_19829295_ChIP-Seq_ESCs_Human1.90234166
19ER_23166858_ChIP-Seq_MCF-7_Human1.89615126
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.84071544
21EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.81162156
22RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80907481
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.80882962
24TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68799089
25POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.68799089
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67781400
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.64304743
28AR_21572438_ChIP-Seq_LNCaP_Human1.59845662
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57861047
30BCAT_22108803_ChIP-Seq_LS180_Human1.57503892
31TP53_22573176_ChIP-Seq_HFKS_Human1.56520606
32MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.56483761
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54664693
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.51613791
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50566643
36* STAT3_23295773_ChIP-Seq_U87_Human1.48957016
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48627143
38IRF1_19129219_ChIP-ChIP_H3396_Human1.45444830
39PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43635144
40IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43558026
41CBP_20019798_ChIP-Seq_JUKART_Human1.43558026
42NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41582572
43SMAD4_21799915_ChIP-Seq_A2780_Human1.38764632
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.38397727
45TCF4_23295773_ChIP-Seq_U87_Human1.38246565
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.37183937
47AR_25329375_ChIP-Seq_VCAP_Human1.36631500
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36562235
49NANOG_19829295_ChIP-Seq_ESCs_Human1.34208545
50SOX2_19829295_ChIP-Seq_ESCs_Human1.34208545
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31826117
52REST_21632747_ChIP-Seq_MESCs_Mouse1.30626366
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30127697
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29119083
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29048738
56GATA3_21878914_ChIP-Seq_MCF-7_Human1.26984869
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.26964226
58MYC_18940864_ChIP-ChIP_HL60_Human1.26342390
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.26213908
60TCF4_22108803_ChIP-Seq_LS180_Human1.23564881
61* FOXA1_25329375_ChIP-Seq_VCAP_Human1.22514660
62* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.22514660
63RNF2_27304074_Chip-Seq_NSC_Mouse1.21799186
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.21694360
65KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18630010
66FLI1_21867929_ChIP-Seq_TH2_Mouse1.18373104
67ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18096586
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.15384762
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14947065
70PRDM14_20953172_ChIP-Seq_ESCs_Human1.13228677
71RUNX2_22187159_ChIP-Seq_PCA_Human1.12975877
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12827921
73CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12645504
74* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12318973
75NCOR_22424771_ChIP-Seq_293T_Human1.11974069
76TP53_16413492_ChIP-PET_HCT116_Human1.10950670
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09419206
78HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09407331
79SMAD4_21741376_ChIP-Seq_EPCs_Human1.08433229
80CRX_20693478_ChIP-Seq_RETINA_Mouse1.07305459
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06656941
82* AR_20517297_ChIP-Seq_VCAP_Human1.06064616
83EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04806841
84EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04466280
85HOXB7_26014856_ChIP-Seq_BT474_Human1.04217024
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00497625
87GABP_17652178_ChIP-ChIP_JURKAT_Human0.99619334
88P53_22387025_ChIP-Seq_ESCs_Mouse0.98639798
89PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98274562
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98200394
91GATA1_22025678_ChIP-Seq_K562_Human0.97446684
92NANOG_18555785_Chip-Seq_ESCs_Mouse0.97083403
93JARID2_20064375_ChIP-Seq_MESCs_Mouse0.96528304
94AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95714437
95TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.95217235
96PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94864729
97TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94705839
98CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.94129407
99STAT3_18555785_Chip-Seq_ESCs_Mouse0.93896011
100ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.93749120

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis2.75480747
2MP0003136_yellow_coat_color2.61910694
3MP0002102_abnormal_ear_morphology2.53438324
4MP0000569_abnormal_digit_pigmentation2.48309069
5MP0003646_muscle_fatigue2.44985810
6MP0008877_abnormal_DNA_methylation2.37580730
7MP0005551_abnormal_eye_electrophysiolog2.35903639
8MP0004043_abnormal_pH_regulation2.30050196
9MP0006292_abnormal_olfactory_placode2.27348340
10MP0002653_abnormal_ependyma_morphology2.20734600
11MP0001968_abnormal_touch/_nociception2.17404694
12MP0002638_abnormal_pupillary_reflex2.04492007
13MP0002837_dystrophic_cardiac_calcinosis2.04051083
14MP0001986_abnormal_taste_sensitivity1.97932995
15MP0004142_abnormal_muscle_tone1.94106123
16MP0002876_abnormal_thyroid_physiology1.91320184
17MP0009745_abnormal_behavioral_response1.90143497
18MP0005174_abnormal_tail_pigmentation1.87637069
19MP0009046_muscle_twitch1.86569849
20MP0008872_abnormal_physiological_respon1.81708256
21MP0005645_abnormal_hypothalamus_physiol1.80125701
22MP0001485_abnormal_pinna_reflex1.71357315
23MP0002938_white_spotting1.70683511
24MP0005253_abnormal_eye_physiology1.70116366
25MP0000566_synostosis1.66810231
26MP0001501_abnormal_sleep_pattern1.63040944
27MP0000427_abnormal_hair_cycle1.62403347
28MP0004885_abnormal_endolymph1.61143626
29MP0004145_abnormal_muscle_electrophysio1.58843752
30MP0005646_abnormal_pituitary_gland1.57133301
31MP0008875_abnormal_xenobiotic_pharmacok1.56285493
32MP0006072_abnormal_retinal_apoptosis1.55300995
33MP0002736_abnormal_nociception_after1.55148568
34MP0000372_irregular_coat_pigmentation1.54678033
35MP0006276_abnormal_autonomic_nervous1.52341585
36MP0003787_abnormal_imprinting1.51535132
37MP0004133_heterotaxia1.48249883
38MP0004742_abnormal_vestibular_system1.46636288
39MP0003011_delayed_dark_adaptation1.44829027
40MP0001486_abnormal_startle_reflex1.42449271
41MP0003880_abnormal_central_pattern1.41768046
42MP0002272_abnormal_nervous_system1.41580558
43MP0005389_reproductive_system_phenotype1.36794055
44MP0002160_abnormal_reproductive_system1.35883422
45MP0002234_abnormal_pharynx_morphology1.33902901
46MP0000631_abnormal_neuroendocrine_gland1.32391439
47MP0000383_abnormal_hair_follicle1.31224395
48MP0002064_seizures1.27947261
49MP0004147_increased_porphyrin_level1.26795646
50MP0001919_abnormal_reproductive_system1.24089283
51MP0002572_abnormal_emotion/affect_behav1.23731937
52MP0002735_abnormal_chemical_nociception1.23297285
53MP0010386_abnormal_urinary_bladder1.19681362
54MP0002733_abnormal_thermal_nociception1.18364588
55MP0001970_abnormal_pain_threshold1.14665866
56MP0005386_behavior/neurological_phenoty1.14062290
57MP0004924_abnormal_behavior1.14062290
58MP0008961_abnormal_basal_metabolism1.13842787
59MP0002095_abnormal_skin_pigmentation1.12540948
60MP0004130_abnormal_muscle_cell1.08928421
61MP0002067_abnormal_sensory_capabilities1.07248515
62MP0002557_abnormal_social/conspecific_i1.06965521
63MP0002928_abnormal_bile_duct1.03409484
64MP0001529_abnormal_vocalization1.02794830
65MP0000026_abnormal_inner_ear1.02021751
66MP0002277_abnormal_respiratory_mucosa1.01682038
67MP0002138_abnormal_hepatobiliary_system1.01679877
68MP0001502_abnormal_circadian_rhythm1.00089680
69MP0004215_abnormal_myocardial_fiber0.99538350
70MP0001664_abnormal_digestion0.99350663
71MP0001984_abnormal_olfaction0.98365410
72MP0005195_abnormal_posterior_eye0.97969082
73MP0002063_abnormal_learning/memory/cond0.97728226
74MP0005084_abnormal_gallbladder_morpholo0.96277377
75MP0005171_absent_coat_pigmentation0.96031708
76MP0005410_abnormal_fertilization0.95170004
77MP0003635_abnormal_synaptic_transmissio0.93563539
78MP0000230_abnormal_systemic_arterial0.90521600
79MP0002752_abnormal_somatic_nervous0.89791972
80MP0003878_abnormal_ear_physiology0.89521770
81MP0005377_hearing/vestibular/ear_phenot0.89521770
82MP0001905_abnormal_dopamine_level0.88587357
83MP0003283_abnormal_digestive_organ0.86555317
84MP0001293_anophthalmia0.85980417
85MP0001873_stomach_inflammation0.85743236
86MP0000015_abnormal_ear_pigmentation0.84792508
87MP0001963_abnormal_hearing_physiology0.84563131
88MP0003137_abnormal_impulse_conducting0.84401730
89MP0003698_abnormal_male_reproductive0.82814918
90MP0005085_abnormal_gallbladder_physiolo0.80621603
91MP0003718_maternal_effect0.80336278
92MP0003252_abnormal_bile_duct0.80046523
93MP0000538_abnormal_urinary_bladder0.77809447
94MP0005167_abnormal_blood-brain_barrier0.77753764
95MP0001764_abnormal_homeostasis0.77576930
96MP0005187_abnormal_penis_morphology0.77141564
97MP0002751_abnormal_autonomic_nervous0.77114304
98MP0008775_abnormal_heart_ventricle0.77098446
99MP0003937_abnormal_limbs/digits/tail_de0.76888803
100MP0005448_abnormal_energy_balance0.76043068

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.92491140
2Molar tooth sign on MRI (HP:0002419)4.27590004
3Abnormality of midbrain morphology (HP:0002418)4.27590004
4Congenital stationary night blindness (HP:0007642)4.05160193
5Pancreatic fibrosis (HP:0100732)4.02065220
6True hermaphroditism (HP:0010459)3.86687585
7Nephronophthisis (HP:0000090)3.61169090
8Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.60903421
9Abnormality of alanine metabolism (HP:0010916)3.60903421
10Hyperalaninemia (HP:0003348)3.60903421
11Abnormality of the renal cortex (HP:0011035)3.48775196
12Attenuation of retinal blood vessels (HP:0007843)3.35432921
13Type II lissencephaly (HP:0007260)3.23967344
14Abnormality of the renal medulla (HP:0100957)3.19507602
15Inability to walk (HP:0002540)3.03516898
16Hyperventilation (HP:0002883)3.03303486
17Medial flaring of the eyebrow (HP:0010747)2.96992141
18Tubular atrophy (HP:0000092)2.96432900
19Chronic hepatic failure (HP:0100626)2.87481518
20Large for gestational age (HP:0001520)2.87365767
21Abolished electroretinogram (ERG) (HP:0000550)2.84395005
22Cystic liver disease (HP:0006706)2.82672309
23Polydipsia (HP:0001959)2.81574870
24Abnormal drinking behavior (HP:0030082)2.81574870
25Abnormal rod and cone electroretinograms (HP:0008323)2.72377488
26Protruding tongue (HP:0010808)2.64381533
27Pendular nystagmus (HP:0012043)2.62644719
28Clumsiness (HP:0002312)2.51523565
29Renal cortical cysts (HP:0000803)2.46934710
30Absent/shortened dynein arms (HP:0200106)2.42351848
31Dynein arm defect of respiratory motile cilia (HP:0012255)2.42351848
32Absent rod-and cone-mediated responses on ERG (HP:0007688)2.41483985
33Decreased central vision (HP:0007663)2.39393144
34Gait imbalance (HP:0002141)2.36444021
35Decreased circulating renin level (HP:0003351)2.36113642
36Keratoconus (HP:0000563)2.35639258
37Increased corneal curvature (HP:0100692)2.35639258
38Gaze-evoked nystagmus (HP:0000640)2.33534285
39Sclerocornea (HP:0000647)2.33187804
40Progressive cerebellar ataxia (HP:0002073)2.32799838
41Lissencephaly (HP:0001339)2.32504225
42Congenital sensorineural hearing impairment (HP:0008527)2.30982099
43Abnormal biliary tract physiology (HP:0012439)2.29795176
44Bile duct proliferation (HP:0001408)2.29795176
45Broad-based gait (HP:0002136)2.29123869
46Polyuria (HP:0000103)2.27718486
47Congenital primary aphakia (HP:0007707)2.27498643
48Progressive inability to walk (HP:0002505)2.27276741
49Genetic anticipation (HP:0003743)2.24688938
50Furrowed tongue (HP:0000221)2.21972088
51Cerebellar dysplasia (HP:0007033)2.21449983
52Abnormality of the pons (HP:0007361)2.17155824
53Anencephaly (HP:0002323)2.16428211
54Severe muscular hypotonia (HP:0006829)2.16234311
55Febrile seizures (HP:0002373)2.15547614
56Congenital hepatic fibrosis (HP:0002612)2.14410834
57Birth length less than 3rd percentile (HP:0003561)2.13541428
58Abnormality of the renal collecting system (HP:0004742)2.13416712
59Aplasia/Hypoplasia of the tongue (HP:0010295)2.12131426
60Hypoplasia of the pons (HP:0012110)2.11621175
61Patellar aplasia (HP:0006443)2.11431643
62Nephrogenic diabetes insipidus (HP:0009806)2.10642786
63Chorioretinal atrophy (HP:0000533)2.10608646
64Bony spicule pigmentary retinopathy (HP:0007737)2.08975312
65Aplasia/Hypoplasia of the tibia (HP:0005772)2.07851703
66Genital tract atresia (HP:0001827)2.06856658
67Concave nail (HP:0001598)2.04962220
68Vaginal atresia (HP:0000148)2.02837854
69Aplasia/Hypoplasia of the patella (HP:0006498)2.02816584
70Duplicated collecting system (HP:0000081)2.02349564
71Male pseudohermaphroditism (HP:0000037)2.02227404
72Fair hair (HP:0002286)2.01545797
73Hypothermia (HP:0002045)1.99007557
74Decreased electroretinogram (ERG) amplitude (HP:0000654)1.97634768
75Postaxial foot polydactyly (HP:0001830)1.95736203
76Abnormal respiratory epithelium morphology (HP:0012253)1.95157033
77Abnormal respiratory motile cilium morphology (HP:0005938)1.95157033
78Stomach cancer (HP:0012126)1.92346959
79Congenital, generalized hypertrichosis (HP:0004540)1.92308357
80Poor coordination (HP:0002370)1.88967508
81Abnormal ciliary motility (HP:0012262)1.83925674
82Optic nerve hypoplasia (HP:0000609)1.83197208
83Abnormal urine output (HP:0012590)1.79159738
84Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.77028334
85Pachygyria (HP:0001302)1.76294312
86Thyroid-stimulating hormone excess (HP:0002925)1.76281534
87Bilateral microphthalmos (HP:0007633)1.71920130
88Absent speech (HP:0001344)1.70231417
89Widely spaced teeth (HP:0000687)1.66127116
90Tachypnea (HP:0002789)1.65193151
91Intestinal atresia (HP:0011100)1.64497152
92Optic disc pallor (HP:0000543)1.63858252
93Postaxial hand polydactyly (HP:0001162)1.63778507
94Hypoplastic iliac wings (HP:0002866)1.62361414
95Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.61568218
963-Methylglutaconic aciduria (HP:0003535)1.60638758
97Ketosis (HP:0001946)1.60327621
98Dandy-Walker malformation (HP:0001305)1.60308146
99Generalized hypopigmentation of hair (HP:0011358)1.57560638
100Aplasia/Hypoplasia of the spleen (HP:0010451)1.57155614

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.03858654
2ADRBK23.53440482
3MKNK23.48796607
4BMPR1B3.15944030
5ACVR1B2.61009295
6TLK12.47611770
7PINK12.46523749
8INSRR2.45871340
9GRK12.41585871
10ZAK2.32713291
11WNK42.25552798
12TAOK32.19279946
13MAP4K22.17531733
14NUAK12.14899007
15WNK32.04237662
16MAPK131.83600197
17MKNK11.80439823
18TXK1.74748447
19CASK1.70786546
20MAP3K41.39285948
21OXSR11.35395732
22DAPK21.33711574
23ADRBK11.21467110
24STK391.21010665
25CAMKK21.15671598
26PAK31.07755779
27TGFBR11.04710357
28MUSK1.01696107
29MAPK151.00268184
30NEK21.00005635
31MAPKAPK50.95676695
32OBSCN0.95038943
33VRK10.89927002
34BLK0.88277833
35MARK10.85749097
36STK30.84776859
37PHKG20.82238698
38PHKG10.82238698
39PIK3CA0.81591597
40PRKCG0.80413872
41TNIK0.79989224
42PRKCQ0.78843046
43VRK20.77961447
44TEC0.75488410
45PRKCE0.74380577
46MAP2K70.74311213
47DYRK20.74235029
48EIF2AK30.74014742
49PNCK0.72769306
50PTK2B0.72607911
51STK38L0.69527505
52KIT0.68322222
53CAMK10.67470442
54TIE10.66601283
55SYK0.64807184
56RPS6KA50.63922572
57WEE10.62341421
58FGFR20.58849407
59CHEK20.58818128
60MARK30.57895287
61AKT30.57628716
62DYRK1A0.56538690
63TRIM280.56381574
64CSNK1G20.55682031
65IKBKB0.54342219
66NTRK30.53900374
67PLK20.53142704
68PLK40.53041244
69PKN10.52613161
70CAMK2A0.50666612
71BRSK20.50285500
72MAPKAPK30.50167800
73SGK20.49537864
74CAMK40.49497650
75ERBB30.48379154
76MAP2K60.48026237
77TAF10.47309448
78STK110.45693374
79NTRK20.45569288
80IRAK10.44592952
81CHUK0.43946135
82CSNK1A10.43440338
83PRKAA20.43035175
84ITK0.42593396
85PRKACA0.41474879
86CSNK1G10.41269152
87BCKDK0.40945714
88NLK0.39176232
89RPS6KA60.39122168
90CSNK1G30.38880881
91PRKCH0.38872136
92WNK10.38373588
93TAOK10.37879090
94CSNK1A1L0.37490291
95MAP3K110.34067711
96SGK4940.33512520
97SGK2230.33512520
98PRKCZ0.33171859
99CAMK1D0.31493234
100ATR0.31117715

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.82250522
2Linoleic acid metabolism_Homo sapiens_hsa005912.73412680
3Phototransduction_Homo sapiens_hsa047442.73345777
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.68781260
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.66556494
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.28057013
7Butanoate metabolism_Homo sapiens_hsa006502.24412088
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.19431236
9Nicotine addiction_Homo sapiens_hsa050332.13118740
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.11287887
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.09568661
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.04901986
13Selenocompound metabolism_Homo sapiens_hsa004501.97408681
14Homologous recombination_Homo sapiens_hsa034401.96065750
15Tryptophan metabolism_Homo sapiens_hsa003801.89348606
16Ether lipid metabolism_Homo sapiens_hsa005651.77652927
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.76923533
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.75759580
19Taste transduction_Homo sapiens_hsa047421.74299825
20Caffeine metabolism_Homo sapiens_hsa002321.70668564
21RNA polymerase_Homo sapiens_hsa030201.65387541
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.65023210
23Olfactory transduction_Homo sapiens_hsa047401.52369174
24Basal transcription factors_Homo sapiens_hsa030221.52207513
25Oxidative phosphorylation_Homo sapiens_hsa001901.51211467
26Fanconi anemia pathway_Homo sapiens_hsa034601.47032056
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.39949601
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.39662234
29Morphine addiction_Homo sapiens_hsa050321.36699251
30Sulfur relay system_Homo sapiens_hsa041221.24556921
31ABC transporters_Homo sapiens_hsa020101.23888407
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.22954687
33One carbon pool by folate_Homo sapiens_hsa006701.22378203
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11353424
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.11109924
36Parkinsons disease_Homo sapiens_hsa050121.10632943
37Chemical carcinogenesis_Homo sapiens_hsa052041.09442258
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08500229
39RNA degradation_Homo sapiens_hsa030181.08264353
40Arachidonic acid metabolism_Homo sapiens_hsa005901.08156918
41Circadian entrainment_Homo sapiens_hsa047131.05965067
42Serotonergic synapse_Homo sapiens_hsa047261.03986176
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02613340
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.00164755
45Propanoate metabolism_Homo sapiens_hsa006401.00057097
46Cardiac muscle contraction_Homo sapiens_hsa042600.99141995
47Protein export_Homo sapiens_hsa030600.97392465
48Glutamatergic synapse_Homo sapiens_hsa047240.94259343
49Primary immunodeficiency_Homo sapiens_hsa053400.93529120
50SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92255990
51Glycerolipid metabolism_Homo sapiens_hsa005610.92016430
52Vitamin digestion and absorption_Homo sapiens_hsa049770.91427910
53Insulin secretion_Homo sapiens_hsa049110.91060451
54Retinol metabolism_Homo sapiens_hsa008300.90955752
55Peroxisome_Homo sapiens_hsa041460.89685686
56Asthma_Homo sapiens_hsa053100.88665997
57Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.87979078
58Ovarian steroidogenesis_Homo sapiens_hsa049130.87347851
59GABAergic synapse_Homo sapiens_hsa047270.87304788
60Calcium signaling pathway_Homo sapiens_hsa040200.86169365
61Huntingtons disease_Homo sapiens_hsa050160.76743549
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75444741
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73899901
64Salivary secretion_Homo sapiens_hsa049700.73436764
65Dorso-ventral axis formation_Homo sapiens_hsa043200.71597568
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.68084056
67Alzheimers disease_Homo sapiens_hsa050100.67307216
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67093430
69Regulation of autophagy_Homo sapiens_hsa041400.66657836
70Histidine metabolism_Homo sapiens_hsa003400.65937939
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64842037
72beta-Alanine metabolism_Homo sapiens_hsa004100.64706727
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63880797
74Purine metabolism_Homo sapiens_hsa002300.61495233
75Graft-versus-host disease_Homo sapiens_hsa053320.59618271
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58192481
77Fat digestion and absorption_Homo sapiens_hsa049750.55179944
78Type I diabetes mellitus_Homo sapiens_hsa049400.53084853
79Cholinergic synapse_Homo sapiens_hsa047250.52857190
80Autoimmune thyroid disease_Homo sapiens_hsa053200.52100063
81Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51645935
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.51568722
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50642175
84Oxytocin signaling pathway_Homo sapiens_hsa049210.49716141
85Long-term depression_Homo sapiens_hsa047300.48676561
86Dopaminergic synapse_Homo sapiens_hsa047280.47785556
87Allograft rejection_Homo sapiens_hsa053300.47632934
88Circadian rhythm_Homo sapiens_hsa047100.46631241
89Hedgehog signaling pathway_Homo sapiens_hsa043400.44595743
90Metabolic pathways_Homo sapiens_hsa011000.42308802
91Mineral absorption_Homo sapiens_hsa049780.42153038
92cAMP signaling pathway_Homo sapiens_hsa040240.41678615
93Gastric acid secretion_Homo sapiens_hsa049710.40885426
94Collecting duct acid secretion_Homo sapiens_hsa049660.39132541
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37814586
96Cocaine addiction_Homo sapiens_hsa050300.37389394
97Pyrimidine metabolism_Homo sapiens_hsa002400.35025963
98Sulfur metabolism_Homo sapiens_hsa009200.34491900
99Lysine degradation_Homo sapiens_hsa003100.33826618
100Nucleotide excision repair_Homo sapiens_hsa034200.33729898

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »