ZNF384

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a C2H2-type zinc finger protein, which may function as a transcription factor. This gene also contains long CAG trinucleotide repeats that encode consecutive glutamine residues. The protein appears to bind and regulate the promoters of the extracellular matrix genes MMP1, MMP3, MMP7 and COL1A1. Studies in mouse suggest that nuclear matrix transcription factors (NP/NMP4) may be part of a general mechanical pathway that couples cell construction and function during extracellular matrix remodeling. Alternative splicing results in multiple transcript variants. Recurrent rearrangements of this gene with the Ewing's sarcoma gene, EWSR1 on chromosome 22, or with the TAF15 gene on chromosome 17, or with the TCF3 (E2A) gene on chromosome 19, have been observed in acute leukemia. A related pseudogene has been identified on chromosome 7. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)4.97671059
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.51963394
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.46839340
43-UTR-mediated mRNA stabilization (GO:0070935)4.42446925
5antigen processing and presentation of endogenous antigen (GO:0019883)4.13171416
6positive regulation of gamma-delta T cell activation (GO:0046645)3.74511321
7positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.62519293
8response to muramyl dipeptide (GO:0032495)3.58274325
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.50528737
10positive regulation by organism of defense response of other organism involved in symbiotic interact3.50528737
11modulation by symbiont of host immune response (GO:0052553)3.50528737
12positive regulation by symbiont of host defense response (GO:0052509)3.50528737
13modulation by symbiont of host defense response (GO:0052031)3.50528737
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.50528737
15intracellular estrogen receptor signaling pathway (GO:0030520)3.24532889
16regulation of histone H3-K27 methylation (GO:0061085)3.23755143
17spliceosomal tri-snRNP complex assembly (GO:0000244)3.23314358
18mannose metabolic process (GO:0006013)3.20671020
19modulation by virus of host process (GO:0019054)3.20597423
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.16979443
21negative regulation of cell killing (GO:0031342)3.16979443
22mRNA stabilization (GO:0048255)3.16130109
23RNA stabilization (GO:0043489)3.16130109
24positive thymic T cell selection (GO:0045059)3.09827315
25modulation by symbiont of host cellular process (GO:0044068)3.05828623
26regulation of NFAT protein import into nucleus (GO:0051532)3.02613377
27response to peptidoglycan (GO:0032494)3.02283010
28response to laminar fluid shear stress (GO:0034616)3.00740594
29thymic T cell selection (GO:0045061)3.00555897
30regulation of gamma-delta T cell activation (GO:0046643)2.98184636
31embryonic process involved in female pregnancy (GO:0060136)2.98002862
32histone H3-K36 demethylation (GO:0070544)2.95184756
33NIK/NF-kappaB signaling (GO:0038061)2.94120545
34leukocyte aggregation (GO:0070486)2.91776535
35apoptotic process involved in morphogenesis (GO:0060561)2.89886263
36regulation of type I interferon-mediated signaling pathway (GO:0060338)2.88669058
37germinal center formation (GO:0002467)2.88192223
38regulation of gamma-delta T cell differentiation (GO:0045586)2.87827495
39cellular response to virus (GO:0098586)2.83180701
40positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.80802690
41detection of bacterium (GO:0016045)2.80149739
42COPI coating of Golgi vesicle (GO:0048205)2.77057216
43Golgi transport vesicle coating (GO:0048200)2.77057216
44detection of other organism (GO:0098543)2.72809562
45adherens junction assembly (GO:0034333)2.72381833
46cell-substrate adherens junction assembly (GO:0007045)2.72104746
47focal adhesion assembly (GO:0048041)2.72104746
48mitotic chromosome condensation (GO:0007076)2.71989168
49regulation of RNA export from nucleus (GO:0046831)2.69033694
50poly(A)+ mRNA export from nucleus (GO:0016973)2.67253204
51response to host (GO:0075136)2.66267802
52response to host defenses (GO:0052200)2.66267802
53response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.66267802
54regulation of interferon-beta biosynthetic process (GO:0045357)2.63384041
55negative thymic T cell selection (GO:0045060)2.60989526
56macrophage activation involved in immune response (GO:0002281)2.59592202
57regulation of nucleobase-containing compound transport (GO:0032239)2.59169920
58negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.57877554
59trophectodermal cell differentiation (GO:0001829)2.55853606
60maternal placenta development (GO:0001893)2.54108760
61regulation of mammary gland epithelial cell proliferation (GO:0033599)2.53933141
62megakaryocyte development (GO:0035855)2.53884133
63cellular response to epidermal growth factor stimulus (GO:0071364)2.53002720
64histone lysine demethylation (GO:0070076)2.52384676
65activation of Rac GTPase activity (GO:0032863)2.51344405
66negative regulation of toll-like receptor signaling pathway (GO:0034122)2.51090494
67pinocytosis (GO:0006907)2.50448862
68T cell selection (GO:0045058)2.49530647
69positive regulation of Cdc42 GTPase activity (GO:0043089)2.48789619
70negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.48731550
71protein localization to endosome (GO:0036010)2.48670623
72tolerance induction (GO:0002507)2.48541702
73pentose-phosphate shunt (GO:0006098)2.47510196
74response to host immune response (GO:0052572)2.46735665
75response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.46735665
76negative regulation of myotube differentiation (GO:0010832)2.45212618
77modulation by virus of host morphology or physiology (GO:0019048)2.45017917
78negative regulation of histone methylation (GO:0031061)2.44960547
79signal complex assembly (GO:0007172)2.43947599
80negative regulation of cell size (GO:0045792)2.42796134
81positive regulation of histone deacetylation (GO:0031065)2.42408706
82epithelial cell differentiation involved in prostate gland development (GO:0060742)2.42072609
83cellular response to interleukin-4 (GO:0071353)2.41576748
84histone H3-K4 methylation (GO:0051568)2.39036538
85regulation of chromatin binding (GO:0035561)2.38813240
86histone H4 deacetylation (GO:0070933)2.37647543
87antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.37166052
88B cell receptor signaling pathway (GO:0050853)2.36543423
89histone demethylation (GO:0016577)2.36509315
90negative regulation of viral release from host cell (GO:1902187)2.36204772
91regulation of ARF GTPase activity (GO:0032312)2.34032979
92negative T cell selection (GO:0043383)2.33119767
93stress fiber assembly (GO:0043149)2.32949757
94regulation of leukocyte degranulation (GO:0043300)2.31749195
95histone H3-K9 demethylation (GO:0033169)2.30984718
96nucleosome disassembly (GO:0006337)2.30566920
97protein-DNA complex disassembly (GO:0032986)2.30566920
98positive T cell selection (GO:0043368)2.29522873
99regulation of glucose import in response to insulin stimulus (GO:2001273)2.28648145
100antigen processing and presentation via MHC class Ib (GO:0002475)2.27992920

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human3.69738326
2VDR_21846776_ChIP-Seq_THP-1_Human3.18144927
3EGR1_19374776_ChIP-ChIP_THP-1_Human2.93328358
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.82760035
5TCF7_22412390_ChIP-Seq_EML_Mouse2.56666366
6KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.51014762
7KDM2B_26808549_Chip-Seq_SUP-B15_Human2.48743890
8ELK3_25401928_ChIP-Seq_HUVEC_Human2.41798400
9TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.29274257
10LXR_22292898_ChIP-Seq_THP-1_Human2.28357177
11KDM2B_26808549_Chip-Seq_DND41_Human2.25692588
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.24544244
13E2F7_22180533_ChIP-Seq_HELA_Human2.12955894
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.04941494
15MAF_26560356_Chip-Seq_TH1_Human2.02043139
16KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.00171328
17VDR_24763502_ChIP-Seq_THP-1_Human1.91854898
18RACK7_27058665_Chip-Seq_MCF-7_Human1.89884929
19FOXM1_23109430_ChIP-Seq_U2OS_Human1.86570219
20TP63_17297297_ChIP-ChIP_HaCaT_Human1.79035912
21* UTX_26944678_Chip-Seq_JUKART_Human1.77537267
22RARG_19884340_ChIP-ChIP_MEFs_Mouse1.76268388
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.72035823
24RUNX1_22412390_ChIP-Seq_EML_Mouse1.66613709
25MAF_26560356_Chip-Seq_TH2_Human1.64292431
26KDM2B_26808549_Chip-Seq_JURKAT_Human1.63378494
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62342172
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.61941588
29ZNF263_19887448_ChIP-Seq_K562_Human1.57970818
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.57155482
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.56669420
32ZFP281_18757296_ChIP-ChIP_E14_Mouse1.53166901
33KDM2B_26808549_Chip-Seq_K562_Human1.52129460
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.51182375
35CTCF_27219007_Chip-Seq_ERYTHROID_Human1.49872434
36CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.48430639
37NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43783175
38DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.42905546
39SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40908465
40TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.38736568
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38680483
42* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.37555466
43ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37459562
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.36885799
45CIITA_25753668_ChIP-Seq_RAJI_Human1.33951105
46MYB_21317192_ChIP-Seq_ERMYB_Mouse1.32934068
47NCOR1_26117541_ChIP-Seq_K562_Human1.32446432
48* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.31672055
49KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.31627209
50SA1_27219007_Chip-Seq_ERYTHROID_Human1.31350640
51HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.30473663
52CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.30069071
53MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.29259479
54STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.29224864
55RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.28967292
56P68_20966046_ChIP-Seq_HELA_Human1.28663033
57SCL_19346495_ChIP-Seq_HPC-7_Human1.28067241
58RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.26804048
59EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26586272
60CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.25284629
61CREB1_26743006_Chip-Seq_LNCaP_Human1.22231295
62MYB_26560356_Chip-Seq_TH1_Human1.22044234
63TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21881785
64IRF8_22096565_ChIP-ChIP_GC-B_Human1.21784224
65GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21575567
66UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21382610
67SMC4_20622854_ChIP-Seq_HELA_Human1.20331925
68FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.20092871
69TET1_21451524_ChIP-Seq_MESCs_Mouse1.19381658
70STAT4_19710469_ChIP-ChIP_TH1__Mouse1.19109446
71WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17546719
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15985094
73RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15615660
74SPI1_23127762_ChIP-Seq_K562_Human1.15211369
75ZFP281_27345836_Chip-Seq_ESCs_Mouse1.13592672
76TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13282330
77CLOCK_20551151_ChIP-Seq_293T_Human1.13143964
78GATA1_19941827_ChIP-Seq_MEL_Mouse1.12935289
79* SPI1_23547873_ChIP-Seq_NB4_Human1.12899680
80KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12804541
81KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12013523
82MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.07827297
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06662226
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06395236
85MYB_26560356_Chip-Seq_TH2_Human1.06224916
86TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.04962030
87* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04099698
88SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02844169
89ESR2_21235772_ChIP-Seq_MCF-7_Human1.02789879
90SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02479661
91* ATF3_27146783_Chip-Seq_COLON_Human1.01726614
92* RUNX1_27514584_Chip-Seq_MCF-7_Human1.01533543
93PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01237349
94GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00536361
95ELF1_20517297_ChIP-Seq_JURKAT_Human0.99506837
96TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99176778
97MYC_19079543_ChIP-ChIP_MESCs_Mouse0.98408216
98DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98243114
99XRN2_22483619_ChIP-Seq_HELA_Human0.96813717
100GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96780452

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to3.36237685
2MP0003705_abnormal_hypodermis_morpholog3.03928040
3MP0009278_abnormal_bone_marrow2.70726653
4MP0005076_abnormal_cell_differentiation2.68989289
5MP0003303_peritoneal_inflammation2.65241619
6MP0003763_abnormal_thymus_physiology2.55742122
7MP0005451_abnormal_body_composition2.44676991
8MP0002396_abnormal_hematopoietic_system2.18558255
9MP0003300_gastrointestinal_ulcer2.05272859
10MP0002877_abnormal_melanocyte_morpholog2.02969114
11MP0008260_abnormal_autophagy1.94344836
12MP0001835_abnormal_antigen_presentation1.89387732
13MP0004947_skin_inflammation1.85101759
14MP0004808_abnormal_hematopoietic_stem1.84790598
15MP0009333_abnormal_splenocyte_physiolog1.84325332
16MP0000685_abnormal_immune_system1.83438746
17MP0001849_ear_inflammation1.80925955
18MP0002009_preneoplasia1.78721872
19MP0005058_abnormal_lysosome_morphology1.77707425
20MP0001800_abnormal_humoral_immune1.74297166
21MP0005000_abnormal_immune_tolerance1.72339693
22MP0002398_abnormal_bone_marrow1.70170205
23MP0000703_abnormal_thymus_morphology1.66142582
24MP0003172_abnormal_lysosome_physiology1.65754192
25MP0003566_abnormal_cell_adhesion1.63692747
26MP0002419_abnormal_innate_immunity1.63279165
27MP0004185_abnormal_adipocyte_glucose1.62899408
28MP0005025_abnormal_response_to1.61668694
29MP0009840_abnormal_foam_cell1.59281450
30MP0005387_immune_system_phenotype1.58573871
31MP0001790_abnormal_immune_system1.58573871
32MP0002420_abnormal_adaptive_immunity1.57287990
33MP0004858_abnormal_nervous_system1.56379561
34MP0001819_abnormal_immune_cell1.55684069
35MP0004264_abnormal_extraembryonic_tissu1.55027289
36MP0002723_abnormal_immune_serum1.54639484
37MP0003091_abnormal_cell_migration1.54027044
38MP0003191_abnormal_cellular_cholesterol1.52709045
39MP0002452_abnormal_antigen_presenting1.49449926
40MP0000858_altered_metastatic_potential1.49091477
41MP0000716_abnormal_immune_system1.41972316
42MP0001533_abnormal_skeleton_physiology1.36895527
43MP0002722_abnormal_immune_system1.36570564
44MP0003111_abnormal_nucleus_morphology1.34070681
45MP0005409_darkened_coat_color1.33872825
46MP0005666_abnormal_adipose_tissue1.33566660
47MP0003453_abnormal_keratinocyte_physiol1.33090403
48MP0005671_abnormal_response_to1.32238829
49MP0001348_abnormal_lacrimal_gland1.32108916
50MP0002405_respiratory_system_inflammati1.31536477
51MP0002429_abnormal_blood_cell1.29483167
52MP0001873_stomach_inflammation1.29294313
53MP0002998_abnormal_bone_remodeling1.28611731
54MP0002166_altered_tumor_susceptibility1.26209005
55MP0000490_abnormal_crypts_of1.26033121
56MP0005375_adipose_tissue_phenotype1.23544067
57MP0010155_abnormal_intestine_physiology1.22057738
58MP0000003_abnormal_adipose_tissue1.20888854
59MP0005397_hematopoietic_system_phenotyp1.17326179
60MP0001545_abnormal_hematopoietic_system1.17326179
61MP0001730_embryonic_growth_arrest1.17317247
62MP0000350_abnormal_cell_proliferation1.16410865
63MP0000689_abnormal_spleen_morphology1.15701519
64MP0003828_pulmonary_edema1.11293690
65MP0003279_aneurysm1.09691398
66MP0001851_eye_inflammation1.08786780
67MP0002249_abnormal_larynx_morphology1.08434161
68MP0000733_abnormal_muscle_development1.06438552
69MP0000678_abnormal_parathyroid_gland1.05913856
70MP0004510_myositis1.05054516
71MP0004381_abnormal_hair_follicle1.04948045
72MP0005621_abnormal_cell_physiology1.04830665
73MP0002089_abnormal_postnatal_growth/wei1.00066117
74MP0008438_abnormal_cutaneous_collagen0.96442651
75MP0004233_abnormal_muscle_weight0.93808375
76MP0005257_abnormal_intraocular_pressure0.93607421
77MP0005464_abnormal_platelet_physiology0.93111772
78MP0009115_abnormal_fat_cell0.91491419
79MP0000313_abnormal_cell_death0.91462067
80MP0003724_increased_susceptibility_to0.90338911
81MP0000767_abnormal_smooth_muscle0.90033746
82MP0003693_abnormal_embryo_hatching0.89912799
83MP0002796_impaired_skin_barrier0.89739634
84MP0003183_abnormal_peptide_metabolism0.89067760
85MP0009931_abnormal_skin_appearance0.88664906
86MP0003077_abnormal_cell_cycle0.88271827
87MP0003115_abnormal_respiratory_system0.87210386
88MP0010352_gastrointestinal_tract_polyps0.86076120
89MP0005390_skeleton_phenotype0.84594728
90MP0003984_embryonic_growth_retardation0.84224670
91MP0003866_abnormal_defecation0.83931312
92MP0001845_abnormal_inflammatory_respons0.83716673
93MP0003656_abnormal_erythrocyte_physiolo0.83492420
94MP0001853_heart_inflammation0.82757307
95MP0010630_abnormal_cardiac_muscle0.82218884
96MP0008961_abnormal_basal_metabolism0.81358844
97MP0002933_joint_inflammation0.81070398
98MP0002019_abnormal_tumor_incidence0.78924036
99MP0009785_altered_susceptibility_to0.78305410
100MP0002080_prenatal_lethality0.77486045

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)3.52360819
2Abnormality of the fingertips (HP:0001211)3.49933213
3Obstructive sleep apnea (HP:0002870)3.20947404
4Hyperacusis (HP:0010780)2.90387922
5Increased IgE level (HP:0003212)2.84894958
6Cellulitis (HP:0100658)2.71915123
7Broad face (HP:0000283)2.68524701
8Recurrent abscess formation (HP:0002722)2.58110961
9Recurrent bacterial skin infections (HP:0005406)2.50762249
10Disproportionate tall stature (HP:0001519)2.41352107
11Gastrointestinal stroma tumor (HP:0100723)2.37491506
12Protrusio acetabuli (HP:0003179)2.29007771
13Colitis (HP:0002583)2.28319259
14Abnormality of macrophages (HP:0004311)2.24233296
15Distal lower limb amyotrophy (HP:0008944)2.22730285
16Spinal cord lesions (HP:0100561)2.22368375
17Syringomyelia (HP:0003396)2.22368375
18Recurrent viral infections (HP:0004429)2.20909066
19Asymmetry of the thorax (HP:0001555)2.18384812
20Long eyelashes (HP:0000527)2.17597945
21Abnormality of the distal phalanx of the thumb (HP:0009617)2.15964064
22Flat acetabular roof (HP:0003180)2.14714746
23Cerebral aneurysm (HP:0004944)2.11542849
24Abnormal delayed hypersensitivity skin test (HP:0002963)2.10889805
25Emphysema (HP:0002097)2.10281468
26Gastrointestinal inflammation (HP:0004386)2.09993199
27Long palpebral fissure (HP:0000637)2.07844546
28Metaphyseal cupping (HP:0003021)2.07463309
29Agammaglobulinemia (HP:0004432)2.05833167
30Mediastinal lymphadenopathy (HP:0100721)2.05656822
31Vertebral compression fractures (HP:0002953)2.05495510
32Centrally nucleated skeletal muscle fibers (HP:0003687)2.03668841
33Segmental peripheral demyelination/remyelination (HP:0003481)2.00283457
34Thin bony cortex (HP:0002753)1.98633174
35Recurrent fungal infections (HP:0002841)1.96143984
36Meningitis (HP:0001287)1.95955884
37Abnormality of the columella (HP:0009929)1.94117836
38Hemorrhage of the eye (HP:0011885)1.93503177
39Dislocated radial head (HP:0003083)1.92161784
40Spontaneous hematomas (HP:0007420)1.91422654
41Fatigue (HP:0012378)1.89875638
42Shallow orbits (HP:0000586)1.88715367
43Increased connective tissue (HP:0009025)1.87697451
44Sparse lateral eyebrow (HP:0005338)1.87011603
45Chronic obstructive pulmonary disease (HP:0006510)1.84517723
46Obstructive lung disease (HP:0006536)1.84517723
47Easy fatigability (HP:0003388)1.83730652
48Gastrointestinal infarctions (HP:0005244)1.82194091
49Inflammation of the large intestine (HP:0002037)1.81726405
50Cervical subluxation (HP:0003308)1.81260234
51Slow saccadic eye movements (HP:0000514)1.80545241
52Gingivitis (HP:0000230)1.78471687
53Panhypogammaglobulinemia (HP:0003139)1.78301450
54Neuronal loss in central nervous system (HP:0002529)1.77449593
55Turricephaly (HP:0000262)1.77146602
56Polygenic inheritance (HP:0010982)1.76446758
57Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.75482751
58Broad distal phalanx of finger (HP:0009836)1.75289968
59Abnormality of the radial head (HP:0003995)1.74807949
60Viral hepatitis (HP:0006562)1.74562212
61Supernumerary ribs (HP:0005815)1.73718099
62Deep palmar crease (HP:0006191)1.73083621
63Abnormality of the thoracic spine (HP:0100711)1.72992651
64Urticaria (HP:0001025)1.72300952
65Myositis (HP:0100614)1.72095226
66Ulnar bowing (HP:0003031)1.69204919
67Spondylolisthesis (HP:0003302)1.68735272
68Aneurysm (HP:0002617)1.65838896
69Vasculitis (HP:0002633)1.64525691
70Biconcave vertebral bodies (HP:0004586)1.63912416
71Granulocytopenia (HP:0001913)1.63574145
72Recurrent skin infections (HP:0001581)1.63194346
73Chronic mucocutaneous candidiasis (HP:0002728)1.61429506
74Recurrent cutaneous fungal infections (HP:0011370)1.61429506
75Supernumerary nipples (HP:0002558)1.61358561
76Pustule (HP:0200039)1.60301536
77Premature skin wrinkling (HP:0100678)1.59208620
78Abnormality of cells of the lymphoid lineage (HP:0012140)1.58456731
79Papilloma (HP:0012740)1.58112697
80Verrucae (HP:0200043)1.58112697
81Abnormality of the phalanges of the hallux (HP:0010057)1.57924295
82Thoracic kyphosis (HP:0002942)1.56411202
83Trigonocephaly (HP:0000243)1.55668383
84Ankyloglossia (HP:0010296)1.55241196
85Germ cell neoplasia (HP:0100728)1.53673648
86Insomnia (HP:0100785)1.52106525
87Abnormality of the peritoneum (HP:0002585)1.51207580
88Thin ribs (HP:0000883)1.50855396
89Persistence of primary teeth (HP:0006335)1.49751274
90Cholecystitis (HP:0001082)1.49580264
91Abnormal gallbladder physiology (HP:0012438)1.49580264
92Lymphopenia (HP:0001888)1.49561088
93Broad palm (HP:0001169)1.48765435
94Dysostosis multiplex (HP:0000943)1.47813763
95Flattened epiphyses (HP:0003071)1.47767440
96Dilatation of the ascending aorta (HP:0005111)1.47166096
97Distal upper limb amyotrophy (HP:0007149)1.46853806
98Upper limb amyotrophy (HP:0009129)1.46853806
99Achilles tendon contracture (HP:0001771)1.46540455
100Restrictive lung disease (HP:0002091)1.45786630

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.31886179
2PRPF4B3.90358412
3CDK123.73485102
4ERN13.57270075
5SMG13.29078462
6SIK12.52009140
7ICK2.33267057
8MAP4K12.19817005
9MAP3K132.17326740
10MAP3K102.16572969
11MAP2K32.03066325
12FGFR41.94461785
13RIPK41.92787875
14EEF2K1.90981411
15SIK31.64101660
16IRAK31.58367712
17SIK21.56499622
18RIPK11.53636262
19MAP3K141.51981215
20IRAK41.42516416
21CDC42BPA1.28122711
22EPHB11.24035943
23ZAP701.21657574
24PRKD21.19276105
25CDK41.17802145
26MARK21.15904045
27TYK21.13882871
28TAOK21.10314620
29TESK21.09691079
30KSR21.07484889
31PDGFRA1.05120242
32PKN21.03069733
33JAK31.01599509
34TBK11.01406194
35TAOK11.01327544
36MAP3K71.00502709
37GRK60.99433494
38MTOR0.98820390
39MAP3K30.98506544
40BRD40.97843844
41NME20.93442774
42PTK60.91823643
43CAMK1D0.91628540
44MAP3K60.90071814
45TNK20.88760703
46BTK0.86283819
47LRRK20.85077599
48CDK60.80820324
49CSK0.78707850
50HIPK20.77110343
51CDK70.76697942
52BLK0.75290634
53HCK0.74816499
54PDPK10.73871999
55MAPK110.73712613
56FGFR30.72159872
57TYRO30.72153719
58PAK40.70937491
59EPHA20.69811080
60MAP3K10.69080275
61FES0.68618717
62MAP2K20.67117601
63STK100.65795133
64MAP3K80.65530705
65IKBKE0.64473633
66JAK10.63513964
67RET0.63096674
68BMX0.63062407
69IRAK20.60321464
70TTN0.59576713
71CDK90.59321866
72RPS6KC10.58711616
73RPS6KL10.58711616
74FGR0.58360595
75MELK0.57962402
76MAPK120.53619918
77PRKD30.52928027
78MARK30.51786097
79RPS6KA20.51651237
80PDK10.51177330
81PTK20.49395634
82MATK0.48959502
83CHUK0.46518992
84PDGFRB0.46147736
85PASK0.45841359
86KIT0.43968848
87LCK0.43736473
88DYRK1B0.43095898
89CSF1R0.42368277
90CAMKK10.42112675
91YES10.40930432
92CAMK1G0.40609957
93SGK30.40553030
94MAPK70.39783132
95RPS6KA60.39052608
96SYK0.38624513
97WNK10.36236268
98JAK20.36228515
99MOS0.35413125
100RPS6KA10.34808172

Predicted pathways (KEGG)

RankGene SetZ-score
1Acute myeloid leukemia_Homo sapiens_hsa052212.34023709
2Chronic myeloid leukemia_Homo sapiens_hsa052202.16923118
3B cell receptor signaling pathway_Homo sapiens_hsa046622.06693727
4Non-small cell lung cancer_Homo sapiens_hsa052232.02726037
5Other glycan degradation_Homo sapiens_hsa005111.97602887
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.83333810
7Notch signaling pathway_Homo sapiens_hsa043301.77818534
8Osteoclast differentiation_Homo sapiens_hsa043801.74249024
9Pancreatic cancer_Homo sapiens_hsa052121.73871866
10Leishmaniasis_Homo sapiens_hsa051401.54964669
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.52303855
12Hepatitis B_Homo sapiens_hsa051611.51404920
13Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.49519980
14VEGF signaling pathway_Homo sapiens_hsa043701.48322218
15Endometrial cancer_Homo sapiens_hsa052131.46415397
16Bladder cancer_Homo sapiens_hsa052191.41736157
17Thyroid cancer_Homo sapiens_hsa052161.41538896
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.40171205
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.39559981
20Renal cell carcinoma_Homo sapiens_hsa052111.37857164
21Neurotrophin signaling pathway_Homo sapiens_hsa047221.37361515
22Prostate cancer_Homo sapiens_hsa052151.37337849
23Influenza A_Homo sapiens_hsa051641.36337366
24T cell receptor signaling pathway_Homo sapiens_hsa046601.36319627
25Measles_Homo sapiens_hsa051621.30230912
26Central carbon metabolism in cancer_Homo sapiens_hsa052301.29021706
27Herpes simplex infection_Homo sapiens_hsa051681.27024943
28Hepatitis C_Homo sapiens_hsa051601.25913069
29Toxoplasmosis_Homo sapiens_hsa051451.25208022
30Colorectal cancer_Homo sapiens_hsa052101.20920265
31TNF signaling pathway_Homo sapiens_hsa046681.19725982
32mTOR signaling pathway_Homo sapiens_hsa041501.18488157
33Apoptosis_Homo sapiens_hsa042101.18250319
34Small cell lung cancer_Homo sapiens_hsa052221.17885670
35Thyroid hormone signaling pathway_Homo sapiens_hsa049191.16395944
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.15168029
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.13888083
38ErbB signaling pathway_Homo sapiens_hsa040121.11592792
39Glioma_Homo sapiens_hsa052141.11147636
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10447237
41Tuberculosis_Homo sapiens_hsa051521.08124166
42Primary immunodeficiency_Homo sapiens_hsa053401.07037720
43HTLV-I infection_Homo sapiens_hsa051661.06316108
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.03679304
45Prolactin signaling pathway_Homo sapiens_hsa049171.01621645
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.01613945
47Choline metabolism in cancer_Homo sapiens_hsa052311.00800209
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96933844
49MicroRNAs in cancer_Homo sapiens_hsa052060.96747680
50Longevity regulating pathway - mammal_Homo sapiens_hsa042110.95123204
51Viral carcinogenesis_Homo sapiens_hsa052030.94954303
52Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93351619
53Phospholipase D signaling pathway_Homo sapiens_hsa040720.92823802
54Viral myocarditis_Homo sapiens_hsa054160.92157646
55Insulin signaling pathway_Homo sapiens_hsa049100.92027233
56Epstein-Barr virus infection_Homo sapiens_hsa051690.91792278
57FoxO signaling pathway_Homo sapiens_hsa040680.89648126
58Pentose phosphate pathway_Homo sapiens_hsa000300.89568042
59Inositol phosphate metabolism_Homo sapiens_hsa005620.88856248
60Estrogen signaling pathway_Homo sapiens_hsa049150.85884799
61Chemokine signaling pathway_Homo sapiens_hsa040620.84933672
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.83730741
63mRNA surveillance pathway_Homo sapiens_hsa030150.82329074
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82303986
65GnRH signaling pathway_Homo sapiens_hsa049120.82015527
66Jak-STAT signaling pathway_Homo sapiens_hsa046300.81546180
67Shigellosis_Homo sapiens_hsa051310.80852900
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.80241694
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.78405592
70Insulin resistance_Homo sapiens_hsa049310.77687981
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77666063
72Endocytosis_Homo sapiens_hsa041440.75805210
73Fructose and mannose metabolism_Homo sapiens_hsa000510.75695514
74Allograft rejection_Homo sapiens_hsa053300.75003245
75Malaria_Homo sapiens_hsa051440.74507352
76Proteoglycans in cancer_Homo sapiens_hsa052050.74145658
77HIF-1 signaling pathway_Homo sapiens_hsa040660.73938005
78Prion diseases_Homo sapiens_hsa050200.73711522
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73481978
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.72815938
81Spliceosome_Homo sapiens_hsa030400.71210460
82Amoebiasis_Homo sapiens_hsa051460.70984689
83Graft-versus-host disease_Homo sapiens_hsa053320.70423398
84Lysine degradation_Homo sapiens_hsa003100.69709006
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68350514
86Antigen processing and presentation_Homo sapiens_hsa046120.66340433
87Autoimmune thyroid disease_Homo sapiens_hsa053200.66297858
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65626109
89Staphylococcus aureus infection_Homo sapiens_hsa051500.64460157
90Platelet activation_Homo sapiens_hsa046110.63966252
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63754766
92Adherens junction_Homo sapiens_hsa045200.63136161
93AMPK signaling pathway_Homo sapiens_hsa041520.62405796
94Focal adhesion_Homo sapiens_hsa045100.59559488
95Base excision repair_Homo sapiens_hsa034100.58822163
96Pathways in cancer_Homo sapiens_hsa052000.57887483
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56356230
98Legionellosis_Homo sapiens_hsa051340.55277995
99African trypanosomiasis_Homo sapiens_hsa051430.53682333
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.52247819

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