ZNF385A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Zinc finger proteins, such as ZNF385A, are regulatory proteins that act as transcription factors, bind single- or double-stranded RNA, or interact with other proteins (Sharma et al., 2004 [PubMed 15527981]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1signal complex assembly (GO:0007172)6.28748823
2neutrophil activation involved in immune response (GO:0002283)5.44018572
3positive regulation of gamma-delta T cell activation (GO:0046645)5.17290225
4positive regulation of mast cell activation involved in immune response (GO:0033008)4.88721207
5positive regulation of mast cell degranulation (GO:0043306)4.88721207
6macrophage activation involved in immune response (GO:0002281)4.88298174
7response to peptidoglycan (GO:0032494)4.84741824
8positive regulation of mast cell activation (GO:0033005)4.82229826
9negative regulation of interleukin-12 production (GO:0032695)4.40340896
10regulation of mast cell degranulation (GO:0043304)4.30682505
11positive regulation by symbiont of host defense response (GO:0052509)4.29075979
12modulation by symbiont of host defense response (GO:0052031)4.29075979
13modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.29075979
14modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.29075979
15positive regulation by organism of defense response of other organism involved in symbiotic interact4.29075979
16modulation by symbiont of host immune response (GO:0052553)4.29075979
17negative regulation of cell killing (GO:0031342)4.28679473
18negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.28679473
19negative regulation of erythrocyte differentiation (GO:0045647)4.22660916
20detection of other organism (GO:0098543)4.13341029
21detection of bacterium (GO:0016045)3.99967646
22positive regulation of leukocyte degranulation (GO:0043302)3.90558727
23granulocyte activation (GO:0036230)3.90489233
24regulation of mast cell activation involved in immune response (GO:0033006)3.89674119
25neutrophil activation (GO:0042119)3.85886960
26regulation of leukocyte degranulation (GO:0043300)3.84940261
27positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.82075791
28regulation of gamma-delta T cell activation (GO:0046643)3.81386353
29regulation of myeloid leukocyte mediated immunity (GO:0002886)3.80868452
30regulation of mast cell activation (GO:0033003)3.42031083
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.37724383
32regulation of regulated secretory pathway (GO:1903305)3.36504495
33detection of external biotic stimulus (GO:0098581)3.33537968
34immunoglobulin mediated immune response (GO:0016064)3.33234140
35macrophage activation (GO:0042116)3.31258988
36response to muramyl dipeptide (GO:0032495)3.29974714
37positive regulation of regulated secretory pathway (GO:1903307)3.27095259
38lipopolysaccharide-mediated signaling pathway (GO:0031663)3.20428948
39production of molecular mediator involved in inflammatory response (GO:0002532)3.20402271
40positive regulation of cellular amide metabolic process (GO:0034250)3.18150341
41myeloid cell activation involved in immune response (GO:0002275)3.16754383
42negative regulation of T cell mediated immunity (GO:0002710)3.16313308
43regulation of gamma-delta T cell differentiation (GO:0045586)3.16099621
44detection of biotic stimulus (GO:0009595)3.13898887
45regulation of interferon-beta biosynthetic process (GO:0045357)3.13032367
46cellular response to thyroid hormone stimulus (GO:0097067)3.08614031
47lipoxygenase pathway (GO:0019372)3.05202257
48detection of molecule of bacterial origin (GO:0032490)3.02535393
49regulation of B cell differentiation (GO:0045577)2.98065913
50antigen processing and presentation of endogenous antigen (GO:0019883)2.93393052
51regulation of necrotic cell death (GO:0010939)2.92663136
52positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.92527165
53regulation of chemokine biosynthetic process (GO:0045073)2.91054736
54germinal center formation (GO:0002467)2.90764192
55negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.89229423
56negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.86802044
57regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.86645147
58negative regulation of lymphocyte mediated immunity (GO:0002707)2.85959569
59cellular extravasation (GO:0045123)2.84405377
60regulation of superoxide anion generation (GO:0032928)2.83601463
61microglial cell activation (GO:0001774)2.83033745
62regulation of T-helper 2 cell differentiation (GO:0045628)2.82197960
63negative regulation of cytokine production involved in immune response (GO:0002719)2.82184487
64positive regulation of type 2 immune response (GO:0002830)2.78635582
65negative regulation of leukocyte mediated immunity (GO:0002704)2.77920578
66positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.75390758
67interferon-gamma-mediated signaling pathway (GO:0060333)2.74640016
68positive regulation of tumor necrosis factor production (GO:0032760)2.74571354
69positive regulation of macrophage differentiation (GO:0045651)2.74116225
70antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.71594301
71amino sugar catabolic process (GO:0046348)2.68968266
72regulation of necroptotic process (GO:0060544)2.68135726
73response to host immune response (GO:0052572)2.67543339
74response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.67543339
75positive regulation of B cell differentiation (GO:0045579)2.65355924
76positive regulation of translational initiation (GO:0045948)2.63110554
77positive regulation of antigen processing and presentation (GO:0002579)2.61553082
78negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.60039593
79T-helper 1 type immune response (GO:0042088)2.59848956
80adenosine receptor signaling pathway (GO:0001973)2.59665785
81positive regulation of monocyte chemotaxis (GO:0090026)2.59096615
82regulation of type 2 immune response (GO:0002828)2.58328307
83regulation of dendritic cell antigen processing and presentation (GO:0002604)2.57691635
84neutrophil chemotaxis (GO:0030593)2.56419685
85leukocyte aggregation (GO:0070486)2.55437876
86regulation of B cell receptor signaling pathway (GO:0050855)2.53260438
87regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.52637089
88glycosphingolipid catabolic process (GO:0046479)2.51555919
89T cell selection (GO:0045058)2.51069613
90regulation of natural killer cell mediated immunity (GO:0002715)2.50341099
91regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.50341099
92neutrophil migration (GO:1990266)2.49259461
93glucose 6-phosphate metabolic process (GO:0051156)2.47990058
94negative regulation of interleukin-1 beta production (GO:0032691)2.47017533
95respiratory burst (GO:0045730)2.46659598
96positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.45608050
97regulation of antigen processing and presentation (GO:0002577)2.45497507
98myeloid dendritic cell differentiation (GO:0043011)2.44336387
99regulation of hypersensitivity (GO:0002883)2.44155866
100B cell receptor signaling pathway (GO:0050853)2.43709349

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human3.19010073
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.07573137
3NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.97648399
4IRF8_21731497_ChIP-ChIP_J774_Mouse2.69736546
5THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.65625767
6VDR_21846776_ChIP-Seq_THP-1_Human2.61948643
7LXR_22292898_ChIP-Seq_THP-1_Human2.60143476
8KDM2B_26808549_Chip-Seq_SUP-B15_Human2.46590837
9VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.35317922
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.32519569
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.22535837
12VDR_24763502_ChIP-Seq_THP-1_Human2.17984528
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.17313851
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.10808889
15IKZF1_21737484_ChIP-ChIP_HCT116_Human2.07252200
16KDM2B_26808549_Chip-Seq_DND41_Human2.03312068
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.03146119
18* SPI1_23127762_ChIP-Seq_K562_Human1.95942233
19KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.95553057
20ELK3_25401928_ChIP-Seq_HUVEC_Human1.93087762
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.88441135
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.87617850
23TCF7_22412390_ChIP-Seq_EML_Mouse1.85657394
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.80897686
25SRY_22984422_ChIP-ChIP_TESTIS_Rat1.77116864
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.76819065
27MAF_26560356_Chip-Seq_TH1_Human1.73046111
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.68274643
29KDM2B_26808549_Chip-Seq_K562_Human1.68230368
30MYC_22102868_ChIP-Seq_BL_Human1.67503063
31* RACK7_27058665_Chip-Seq_MCF-7_Human1.63512164
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61957477
33RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.61632588
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.60196071
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58218087
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58087872
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.53442455
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.52809276
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.51994808
40* SA1_27219007_Chip-Seq_ERYTHROID_Human1.45710438
41PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.45487271
42KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.45210727
43EGR1_19032775_ChIP-ChIP_M12_Human1.43800563
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.42941219
45SCL_19346495_ChIP-Seq_HPC-7_Human1.42690414
46GATA1_19941827_ChIP-Seq_MEL_Mouse1.41970839
47* ESR2_21235772_ChIP-Seq_MCF-7_Human1.40873198
48CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39631385
49UTX_26944678_Chip-Seq_JUKART_Human1.39550893
50* SPI1_23547873_ChIP-Seq_NB4_Human1.39035106
51CTCF_27219007_Chip-Seq_ERYTHROID_Human1.38027469
52DNAJC2_21179169_ChIP-ChIP_NT2_Human1.37649478
53VDR_24787735_ChIP-Seq_THP-1_Human1.36445671
54* P68_20966046_ChIP-Seq_HELA_Human1.36366900
55TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.35196901
56SMC4_20622854_ChIP-Seq_HELA_Human1.33820156
57SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.33017773
58MAF_26560356_Chip-Seq_TH2_Human1.32652297
59STAT4_19710469_ChIP-ChIP_TH1__Mouse1.31673599
60KDM2B_26808549_Chip-Seq_JURKAT_Human1.31162274
61* BCOR_27268052_Chip-Seq_Bcells_Human1.30768233
62GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30716459
63Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29029575
64PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28408044
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.27084127
66EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26262158
67PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24042492
68NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.23201059
69UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20787191
70RUNX_20019798_ChIP-Seq_JUKART_Human1.20530172
71* BCL6_27268052_Chip-Seq_Bcells_Human1.20091466
72LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19542688
73IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.18700180
74CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18698067
75LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.18278272
76ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18127404
77GATA1_19941826_ChIP-Seq_K562_Human1.17865823
78SA1_27219007_Chip-Seq_Bcells_Human1.17810510
79SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17657694
80TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16466071
81SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15813525
82STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.13656262
83ELF1_20517297_ChIP-Seq_JURKAT_Human1.11976665
84CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11701299
85CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10653173
86GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09897463
87DROSHA_22980978_ChIP-Seq_HELA_Human1.09291961
88CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08086231
89EGR1_19374776_ChIP-ChIP_THP-1_Human1.08023070
90SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.07470079
91TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05443713
92FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.03057718
93TET1_21451524_ChIP-Seq_MESCs_Mouse1.02736528
94TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.01734940
95PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01283021
96CTCF_26484167_Chip-Seq_Bcells_Mouse1.01148524
97NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01104238
98SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97972330
99GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96914468
100CTCF_27219007_Chip-Seq_Bcells_Human0.96615554

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.20648767
2MP0003303_peritoneal_inflammation3.79468290
3MP0005058_abnormal_lysosome_morphology3.72522184
4MP0003724_increased_susceptibility_to3.27131007
5MP0006082_CNS_inflammation3.01157203
6MP0002148_abnormal_hypersensitivity_rea2.92132608
7MP0001835_abnormal_antigen_presentation2.82543174
8MP0002419_abnormal_innate_immunity2.78909814
9MP0005000_abnormal_immune_tolerance2.60813022
10MP0003172_abnormal_lysosome_physiology2.60710546
11MP0001790_abnormal_immune_system2.58219164
12MP0005387_immune_system_phenotype2.58219164
13MP0005025_abnormal_response_to2.51029663
14MP0005671_abnormal_response_to2.47109099
15MP0009785_altered_susceptibility_to2.37090091
16MP0003075_altered_response_to2.32504199
17MP0001533_abnormal_skeleton_physiology2.26890915
18MP0003191_abnormal_cellular_cholesterol2.15732318
19MP0003690_abnormal_glial_cell2.10634773
20MP0002723_abnormal_immune_serum2.08689312
21MP0001800_abnormal_humoral_immune2.06030616
22MP0000685_abnormal_immune_system2.04489199
23MP0004947_skin_inflammation2.03861818
24MP0002452_abnormal_antigen_presenting2.03462108
25MP0004510_myositis1.96904742
26MP0003300_gastrointestinal_ulcer1.94394755
27MP0009278_abnormal_bone_marrow1.93390408
28MP0000604_amyloidosis1.87581320
29MP0001819_abnormal_immune_cell1.84015274
30MP0002420_abnormal_adaptive_immunity1.83181759
31MP0008260_abnormal_autophagy1.79654555
32MP0000343_altered_response_to1.78803913
33MP0009764_decreased_sensitivity_to1.71149536
34MP0009333_abnormal_splenocyte_physiolog1.63661122
35MP0009840_abnormal_foam_cell1.63187324
36MP0005167_abnormal_blood-brain_barrier1.62931303
37MP0003329_amyloid_beta_deposits1.59658827
38MP0010155_abnormal_intestine_physiology1.55173048
39MP0002796_impaired_skin_barrier1.51868871
40MP0001845_abnormal_inflammatory_respons1.51595661
41MP0000858_altered_metastatic_potential1.50277896
42MP0002998_abnormal_bone_remodeling1.46891049
43MP0003453_abnormal_keratinocyte_physiol1.45797568
44MP0005464_abnormal_platelet_physiology1.40561051
45MP0005451_abnormal_body_composition1.39999192
46MP0004130_abnormal_muscle_cell1.36528040
47MP0000920_abnormal_myelination1.35379474
48MP0005166_decreased_susceptibility_to1.34660077
49MP0002405_respiratory_system_inflammati1.32942642
50MP0003828_pulmonary_edema1.28848063
51MP0008469_abnormal_protein_level1.26906424
52MP0003448_altered_tumor_morphology1.25901700
53MP0003879_abnormal_hair_cell1.23852022
54MP0000716_abnormal_immune_system1.21964387
55MP0008004_abnormal_stomach_pH1.21463844
56MP0005397_hematopoietic_system_phenotyp1.20804070
57MP0001545_abnormal_hematopoietic_system1.20804070
58MP0001853_heart_inflammation1.15810716
59MP0005310_abnormal_salivary_gland1.13018130
60MP0003011_delayed_dark_adaptation1.12298613
61MP0004381_abnormal_hair_follicle1.11379317
62MP0001851_eye_inflammation1.08557241
63MP0005390_skeleton_phenotype1.05204516
64MP0002277_abnormal_respiratory_mucosa1.03533000
65MP0000579_abnormal_nail_morphology1.03110201
66MP0002398_abnormal_bone_marrow1.01539309
67MP0003183_abnormal_peptide_metabolism0.91292680
68MP0008874_decreased_physiological_sensi0.89677081
69MP0004859_abnormal_synaptic_plasticity0.89481612
70MP0003705_abnormal_hypodermis_morpholog0.89442034
71MP0004185_abnormal_adipocyte_glucose0.88862164
72MP0001501_abnormal_sleep_pattern0.87982417
73MP0005535_abnormal_body_temperature0.87454586
74MP0004883_abnormal_blood_vessel0.87130764
75MP0002429_abnormal_blood_cell0.86955170
76MP0005377_hearing/vestibular/ear_phenot0.84674636
77MP0003878_abnormal_ear_physiology0.84674636
78MP0000689_abnormal_spleen_morphology0.84264692
79MP0002722_abnormal_immune_system0.83144161
80MP0003646_muscle_fatigue0.82063407
81MP0002064_seizures0.80371191
82MP0001986_abnormal_taste_sensitivity0.74744244
83MP0005666_abnormal_adipose_tissue0.74647690
84MP0003633_abnormal_nervous_system0.73754823
85MP0002933_joint_inflammation0.73419816
86MP0004858_abnormal_nervous_system0.73216611
87MP0002971_abnormal_brown_adipose0.72075547
88MP0003634_abnormal_glial_cell0.71046338
89MP0000465_gastrointestinal_hemorrhage0.70238406
90MP0003866_abnormal_defecation0.69662264
91MP0005164_abnormal_response_to0.68601988
92MP0005647_abnormal_sex_gland0.67209070
93MP0000678_abnormal_parathyroid_gland0.62745747
94MP0005083_abnormal_biliary_tract0.62695517
95MP0003656_abnormal_erythrocyte_physiolo0.61639998
96MP0001663_abnormal_digestive_system0.61388062
97MP0003806_abnormal_nucleotide_metabolis0.61009118
98MP0005423_abnormal_somatic_nervous0.59443495
99MP0002254_reproductive_system_inflammat0.58542225
100MP0003635_abnormal_synaptic_transmissio0.57336756

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)5.21439274
2Abnormality of liposaccharide metabolism (HP:0010968)5.21439274
3Abnormality of glycosphingolipid metabolism (HP:0004343)5.21439274
4Recurrent bacterial skin infections (HP:0005406)5.03281903
5Abnormality of macrophages (HP:0004311)4.86716520
6Eczematoid dermatitis (HP:0000976)4.73604566
7Increased cerebral lipofuscin (HP:0011813)4.72005852
8Recurrent abscess formation (HP:0002722)4.69166089
9Myositis (HP:0100614)4.08239607
10Orchitis (HP:0100796)4.05268816
11Increased neuronal autofluorescent lipopigment (HP:0002074)3.97781003
12Optic neuritis (HP:0100653)3.84932865
13Retrobulbar optic neuritis (HP:0100654)3.84932865
14Mutism (HP:0002300)3.50894512
15Amyloidosis (HP:0011034)3.50206950
16Recurrent gram-negative bacterial infections (HP:0005420)3.49182505
17Dysostosis multiplex (HP:0000943)3.48023925
18Increased IgE level (HP:0003212)3.47966370
19Stomatitis (HP:0010280)3.37670929
20Systemic lupus erythematosus (HP:0002725)3.35516230
21Vacuolated lymphocytes (HP:0001922)3.23198800
22Loss of speech (HP:0002371)3.17554467
23Chronic obstructive pulmonary disease (HP:0006510)3.16503108
24Obstructive lung disease (HP:0006536)3.16503108
25Elevated erythrocyte sedimentation rate (HP:0003565)3.14035700
26Neurofibrillary tangles (HP:0002185)3.10962692
27Axonal loss (HP:0003447)3.06172902
28Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.02923004
29Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.02627182
30Mediastinal lymphadenopathy (HP:0100721)3.00494206
31Recurrent skin infections (HP:0001581)2.96892738
32Keratoconjunctivitis sicca (HP:0001097)2.85663984
33Personality changes (HP:0000751)2.85456896
34Neuronal loss in central nervous system (HP:0002529)2.82850136
35Disinhibition (HP:0000734)2.78166321
36Spontaneous hematomas (HP:0007420)2.69955681
37Purpura (HP:0000979)2.69740160
38Abnormality of mucopolysaccharide metabolism (HP:0011020)2.61980606
39Abnormality of polysaccharide metabolism (HP:0011012)2.61980606
40Abnormality of glycosaminoglycan metabolism (HP:0004371)2.61980606
41Abnormality of binocular vision (HP:0011514)2.59149698
42Diplopia (HP:0000651)2.59149698
43Keratoconjunctivitis (HP:0001096)2.57597984
44Supranuclear gaze palsy (HP:0000605)2.55721719
45Gastrointestinal infarctions (HP:0005244)2.54547934
46Urticaria (HP:0001025)2.54257258
47Increased serum ferritin (HP:0003281)2.54053721
48Meningitis (HP:0001287)2.48013329
49Glomerulonephritis (HP:0000099)2.43977484
50Delusions (HP:0000746)2.43212058
51Gingivitis (HP:0000230)2.40395055
52Mucopolysacchariduria (HP:0008155)2.39935161
53Urinary glycosaminoglycan excretion (HP:0003541)2.39935161
54Recurrent fungal infections (HP:0002841)2.38547092
55Vasculitis (HP:0002633)2.37738795
56Memory impairment (HP:0002354)2.29826675
57Gangrene (HP:0100758)2.29022872
58Cerebral inclusion bodies (HP:0100314)2.28306712
59Hemoptysis (HP:0002105)2.27869089
60Agitation (HP:0000713)2.27396270
61Petechiae (HP:0000967)2.24920775
62Prolonged neonatal jaundice (HP:0006579)2.22858243
63Progressive neurologic deterioration (HP:0002344)2.19412114
64Pulmonary infiltrates (HP:0002113)2.18473377
65Episodic fever (HP:0001954)2.16917285
66Abnormality of nail color (HP:0100643)2.15877532
67Encephalitis (HP:0002383)2.14395059
68Vertigo (HP:0002321)2.13818609
69Apathy (HP:0000741)2.12400491
70Nuclear cataract (HP:0100018)2.11489682
71Diminished motivation (HP:0000745)2.09661935
72Thick nail (HP:0001805)2.07459230
73Segmental peripheral demyelination/remyelination (HP:0003481)2.06325008
74Polygenic inheritance (HP:0010982)2.02451812
75Dementia (HP:0000726)2.02166351
76Cellulitis (HP:0100658)2.01222458
77Abnormality of iron homeostasis (HP:0011031)1.99156506
78Pustule (HP:0200039)1.98594127
79Prolonged bleeding time (HP:0003010)1.98530864
80Chronic mucocutaneous candidiasis (HP:0002728)1.96934974
81Recurrent cutaneous fungal infections (HP:0011370)1.96934974
82Inflammation of the large intestine (HP:0002037)1.96626662
83Hepatosplenomegaly (HP:0001433)1.96282563
84Obstructive sleep apnea (HP:0002870)1.96130680
85Gastrointestinal inflammation (HP:0004386)1.95220290
86Ventricular fibrillation (HP:0001663)1.94642091
87Acne (HP:0001061)1.93614741
88Autoimmune thrombocytopenia (HP:0001973)1.92747138
89Chest pain (HP:0100749)1.91982543
90Peripheral hypomyelination (HP:0007182)1.91194853
91Hypercortisolism (HP:0001578)1.91047086
92Slow saccadic eye movements (HP:0000514)1.90724050
93Arterial thrombosis (HP:0004420)1.89342236
94Pulmonary embolism (HP:0002204)1.85842354
95Colitis (HP:0002583)1.82852304
96Abnormal blistering of the skin (HP:0008066)1.82389018
97Abnormality of the periventricular white matter (HP:0002518)1.78497519
98Visual hallucinations (HP:0002367)1.76831819
99Hemiplegia (HP:0002301)1.76715138
100Parakeratosis (HP:0001036)1.76611220

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK17.55421301
2RIPK43.96804632
3MAP4K12.93304348
4BMPR22.51960800
5TRIB32.48991086
6PRPF4B2.45653133
7BLK2.39298498
8ERN12.16149080
9CSK2.02259363
10TYK21.82384862
11PDPK11.79621604
12IRAK31.77042470
13MAP3K111.74914773
14IRAK41.74770132
15FGR1.73777775
16TNK21.69719819
17TAOK11.52410103
18MAP2K31.51093823
19FES1.50827710
20PRKCI1.36633113
21TAOK21.34564733
22ZAP701.34148386
23MAP3K31.32334389
24EPHB11.30499801
25TBK11.24629775
26MATK1.20106867
27MARK21.19328685
28DAPK21.14906104
29SIK11.14850927
30MAP3K131.13809947
31CAMKK11.08450758
32MAP3K11.07167683
33SYK1.06060532
34JAK31.04568136
35MAP3K141.01587989
36KSR20.99179671
37IKBKB0.98334685
38GRK60.92249665
39GRK70.91111351
40BTK0.89197256
41JAK20.88217254
42CDC42BPA0.88114267
43SIK20.87811258
44ARAF0.85777327
45SMG10.84074817
46NME20.83855151
47IRAK20.83254174
48SIK30.82755000
49DAPK30.81774678
50HCK0.80726229
51DDR20.79922337
52MAPK120.79852628
53TESK20.78828549
54YES10.76097770
55IKBKE0.75592617
56LYN0.75198142
57CSF1R0.73451136
58CAMK1D0.70289682
59MAPKAPK30.68685113
60PRKD30.67807359
61PDK10.67325960
62LCK0.66413061
63TGFBR20.64367475
64PRKD20.63862892
65JAK10.63179482
66PTK60.62211608
67ICK0.61056624
68FYN0.60923443
69PRKCZ0.60278219
70MAPK70.59715647
71MOS0.59680427
72TESK10.58979264
73HIPK20.58918217
74PRKCD0.58142947
75PRKCG0.54137688
76NTRK30.53303318
77TXK0.51449528
78TYRO30.50468079
79MAPK40.50405690
80RPS6KL10.48544820
81RPS6KC10.48544820
82MAP2K60.48119082
83RPS6KA20.48058278
84PIM20.46734373
85ABL20.44912848
86PAK60.43823736
87KIT0.43778749
88MARK30.42224239
89RPS6KA60.41867109
90STK380.41607860
91MAP3K60.39136361
92MAP3K90.36048882
93CAMKK20.34325090
94DAPK10.34311827
95MAPK150.33665035
96BMX0.32667314
97STK110.31455433
98SGK30.31260863
99IRAK10.30850021
100MAP2K20.30755937

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043802.50994436
2Other glycan degradation_Homo sapiens_hsa005112.50837715
3Staphylococcus aureus infection_Homo sapiens_hsa051502.49172458
4Leishmaniasis_Homo sapiens_hsa051402.36449536
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.19061099
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.18356515
7Graft-versus-host disease_Homo sapiens_hsa053322.14164548
8Lysosome_Homo sapiens_hsa041422.07539889
9Tuberculosis_Homo sapiens_hsa051522.06447963
10Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.04296799
11Allograft rejection_Homo sapiens_hsa053301.91329591
12Acute myeloid leukemia_Homo sapiens_hsa052211.88867026
13Rheumatoid arthritis_Homo sapiens_hsa053231.73447242
14Malaria_Homo sapiens_hsa051441.71919334
15Autoimmune thyroid disease_Homo sapiens_hsa053201.62800516
16B cell receptor signaling pathway_Homo sapiens_hsa046621.62448727
17Asthma_Homo sapiens_hsa053101.58966679
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.57939344
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.46601217
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.43613545
21Pertussis_Homo sapiens_hsa051331.40598159
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.40238219
23Antigen processing and presentation_Homo sapiens_hsa046121.39694047
24TNF signaling pathway_Homo sapiens_hsa046681.34461253
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.34279228
26Phagosome_Homo sapiens_hsa041451.32414534
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.31156395
28Type I diabetes mellitus_Homo sapiens_hsa049401.31045830
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.31000235
30Toxoplasmosis_Homo sapiens_hsa051451.25492030
31Chemokine signaling pathway_Homo sapiens_hsa040621.24580695
32ErbB signaling pathway_Homo sapiens_hsa040121.24386347
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.19684883
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.17899062
35Synaptic vesicle cycle_Homo sapiens_hsa047211.15503278
36T cell receptor signaling pathway_Homo sapiens_hsa046601.13805005
37Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.10693820
38VEGF signaling pathway_Homo sapiens_hsa043701.09412442
39Collecting duct acid secretion_Homo sapiens_hsa049661.06889170
40Salmonella infection_Homo sapiens_hsa051321.03472449
41Legionellosis_Homo sapiens_hsa051341.01183435
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99087098
43Hematopoietic cell lineage_Homo sapiens_hsa046400.98584433
44Influenza A_Homo sapiens_hsa051640.97352607
45mTOR signaling pathway_Homo sapiens_hsa041500.96922641
46Prion diseases_Homo sapiens_hsa050200.96301819
47Phospholipase D signaling pathway_Homo sapiens_hsa040720.92448133
48African trypanosomiasis_Homo sapiens_hsa051430.90252895
49GnRH signaling pathway_Homo sapiens_hsa049120.86607995
50Choline metabolism in cancer_Homo sapiens_hsa052310.84807166
51Hepatitis C_Homo sapiens_hsa051600.84700409
52Viral myocarditis_Homo sapiens_hsa054160.84362485
53Measles_Homo sapiens_hsa051620.83165716
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.83014226
55HIF-1 signaling pathway_Homo sapiens_hsa040660.77943439
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77722983
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76658078
58Sphingolipid signaling pathway_Homo sapiens_hsa040710.76453437
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.75806089
60Adipocytokine signaling pathway_Homo sapiens_hsa049200.75531774
61Sulfur relay system_Homo sapiens_hsa041220.74993617
62Amoebiasis_Homo sapiens_hsa051460.74483249
63Notch signaling pathway_Homo sapiens_hsa043300.73943844
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.73833363
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72649933
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71982484
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71072363
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70720572
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70686207
70Platelet activation_Homo sapiens_hsa046110.69560113
71Endocytosis_Homo sapiens_hsa041440.69254895
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68776661
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66822802
74Gastric acid secretion_Homo sapiens_hsa049710.65124779
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64598779
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62492650
77Type II diabetes mellitus_Homo sapiens_hsa049300.62341644
78Dorso-ventral axis formation_Homo sapiens_hsa043200.61677266
79Apoptosis_Homo sapiens_hsa042100.60649539
80Herpes simplex infection_Homo sapiens_hsa051680.60600704
81Tyrosine metabolism_Homo sapiens_hsa003500.60513612
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60243106
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59392915
84Long-term potentiation_Homo sapiens_hsa047200.59349447
85Estrogen signaling pathway_Homo sapiens_hsa049150.59085040
86Bladder cancer_Homo sapiens_hsa052190.58224822
87Insulin signaling pathway_Homo sapiens_hsa049100.56923520
88Insulin resistance_Homo sapiens_hsa049310.54320960
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.54216429
90Prolactin signaling pathway_Homo sapiens_hsa049170.54168360
91Morphine addiction_Homo sapiens_hsa050320.53309448
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52445918
93Hepatitis B_Homo sapiens_hsa051610.49385111
94Shigellosis_Homo sapiens_hsa051310.47163487
95Mineral absorption_Homo sapiens_hsa049780.45229993
96Non-small cell lung cancer_Homo sapiens_hsa052230.43583420
97Primary immunodeficiency_Homo sapiens_hsa053400.42726665
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42421796
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42389048
100Glioma_Homo sapiens_hsa052140.42076140

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