ZNF385B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)6.15827465
2glutamate secretion (GO:0014047)5.50069596
3synaptic vesicle maturation (GO:0016188)5.49421208
4membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.94541047
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.90372475
6regulation of synaptic vesicle exocytosis (GO:2000300)4.85363076
7synaptic vesicle exocytosis (GO:0016079)4.73716078
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.72524429
9neuronal action potential propagation (GO:0019227)4.71654076
10sodium ion export (GO:0071436)4.43050898
11regulation of synaptic vesicle transport (GO:1902803)4.28064127
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.20971065
13cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.19969322
14cellular potassium ion homeostasis (GO:0030007)4.16587912
15neurotransmitter secretion (GO:0007269)4.03364645
16vocalization behavior (GO:0071625)3.91033615
17cellular sodium ion homeostasis (GO:0006883)3.90564418
18cerebellar granule cell differentiation (GO:0021707)3.89674694
19neurotransmitter-gated ion channel clustering (GO:0072578)3.79902045
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.69492069
21regulation of neuronal synaptic plasticity (GO:0048168)3.65841493
22positive regulation of synapse maturation (GO:0090129)3.59882287
23locomotory exploration behavior (GO:0035641)3.54696634
24cell communication by electrical coupling (GO:0010644)3.48748852
25protein localization to synapse (GO:0035418)3.46146934
26regulation of dendritic spine morphogenesis (GO:0061001)3.41756332
27regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.32619223
28gamma-aminobutyric acid transport (GO:0015812)3.31515846
29membrane depolarization during action potential (GO:0086010)3.31396704
30regulation of long-term neuronal synaptic plasticity (GO:0048169)3.31067270
31neurotransmitter transport (GO:0006836)3.25966477
32postsynaptic membrane organization (GO:0001941)3.23504966
33exploration behavior (GO:0035640)3.22970606
34regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.22069542
35L-amino acid import (GO:0043092)3.21962622
36positive regulation of membrane potential (GO:0045838)3.21736398
37cell communication involved in cardiac conduction (GO:0086065)3.17464548
38regulation of voltage-gated calcium channel activity (GO:1901385)3.16024208
39positive regulation of dendritic spine development (GO:0060999)3.13670527
40regulation of synapse maturation (GO:0090128)3.12335984
41synaptic transmission, glutamatergic (GO:0035249)3.10989709
42ionotropic glutamate receptor signaling pathway (GO:0035235)3.10986532
43regulation of neurotransmitter levels (GO:0001505)3.09215954
44regulation of dendritic spine development (GO:0060998)3.05997970
45positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.04764645
46regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.04376856
47regulation of glutamate receptor signaling pathway (GO:1900449)3.04010738
48regulation of excitatory postsynaptic membrane potential (GO:0060079)3.01436260
49positive regulation of dendritic spine morphogenesis (GO:0061003)3.01064597
50long-term memory (GO:0007616)3.01019295
51regulation of cell communication by electrical coupling (GO:0010649)2.98876355
52gamma-aminobutyric acid signaling pathway (GO:0007214)2.98285169
53synaptic vesicle endocytosis (GO:0048488)2.97446209
54regulation of neurotransmitter secretion (GO:0046928)2.96761472
55neuron cell-cell adhesion (GO:0007158)2.95846810
56positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.95628450
57regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.95455713
58neuromuscular synaptic transmission (GO:0007274)2.95103646
59sarcoplasmic reticulum calcium ion transport (GO:0070296)2.94500326
60neuron-neuron synaptic transmission (GO:0007270)2.94398669
61regulation of sodium ion transmembrane transporter activity (GO:2000649)2.93246501
62regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.89842751
63C4-dicarboxylate transport (GO:0015740)2.84977682
64regulation of postsynaptic membrane potential (GO:0060078)2.82923641
65potassium ion import (GO:0010107)2.81283310
66cerebellar Purkinje cell differentiation (GO:0021702)2.80636496
67regulation of synaptic plasticity (GO:0048167)2.80568412
68phosphate ion transmembrane transport (GO:0035435)2.79799949
69glutamate receptor signaling pathway (GO:0007215)2.78359239
70sodium ion homeostasis (GO:0055078)2.77095078
71positive regulation of neurotransmitter secretion (GO:0001956)2.76109519
72amino acid import (GO:0043090)2.72798039
73membrane depolarization (GO:0051899)2.70471501
74neuronal ion channel clustering (GO:0045161)2.68377607
75relaxation of cardiac muscle (GO:0055119)2.68064616
76positive regulation of neurotransmitter transport (GO:0051590)2.65355330
77cardiac muscle contraction (GO:0060048)2.63927330
78regulation of neurotransmitter transport (GO:0051588)2.61868684
79cardiac muscle hypertrophy (GO:0003300)2.61298079
80neurotransmitter uptake (GO:0001504)2.61064315
81regulation of sodium ion transmembrane transport (GO:1902305)2.60938839
82serotonin metabolic process (GO:0042428)2.60897128
83potassium ion homeostasis (GO:0055075)2.60818449
84neuromuscular process controlling balance (GO:0050885)2.59677050
85behavioral response to cocaine (GO:0048148)2.59102934
86negative regulation of synaptic transmission, GABAergic (GO:0032229)2.59008715
87dendritic spine morphogenesis (GO:0060997)2.57929531
88regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.57444812
89primary amino compound metabolic process (GO:1901160)2.56407886
90cytoskeletal anchoring at plasma membrane (GO:0007016)2.55220896
91regulation of ARF protein signal transduction (GO:0032012)2.55025093
92dendritic spine organization (GO:0097061)2.54206636
93layer formation in cerebral cortex (GO:0021819)2.50361943
94neurotransmitter catabolic process (GO:0042135)2.49685534
95chemosensory behavior (GO:0007635)2.49384573
96regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.48761942
97regulation of synapse structural plasticity (GO:0051823)2.48526918
98phosphate ion transport (GO:0006817)2.48089644
99positive regulation of dendrite development (GO:1900006)2.45641841
100striated muscle hypertrophy (GO:0014897)2.44645967

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.87311732
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.33875122
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.20913454
4GBX2_23144817_ChIP-Seq_PC3_Human3.01687626
5PIAS1_25552417_ChIP-Seq_VCAP_Human2.29045288
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.28580399
7REST_21632747_ChIP-Seq_MESCs_Mouse2.26661807
8RARB_27405468_Chip-Seq_BRAIN_Mouse2.23834884
9DROSHA_22980978_ChIP-Seq_HELA_Human2.20747868
10TAF15_26573619_Chip-Seq_HEK293_Human2.20227601
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.18300468
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.00027023
13SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.97637017
14EZH2_27304074_Chip-Seq_ESCs_Mouse1.95868242
15MTF2_20144788_ChIP-Seq_MESCs_Mouse1.94367802
16RNF2_18974828_ChIP-Seq_MESCs_Mouse1.91836556
17EZH2_18974828_ChIP-Seq_MESCs_Mouse1.91836556
18REST_18959480_ChIP-ChIP_MESCs_Mouse1.91480019
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90956980
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.90043967
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.85637431
22JARID2_20075857_ChIP-Seq_MESCs_Mouse1.83358576
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.80778684
24AR_21572438_ChIP-Seq_LNCaP_Human1.78571197
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.74344897
26IGF1R_20145208_ChIP-Seq_DFB_Human1.73831827
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.72986088
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.70041514
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.69274770
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.68237910
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65601945
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63395433
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62558814
34* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61776583
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.56715204
36RNF2_27304074_Chip-Seq_NSC_Mouse1.54762070
37SMAD4_21799915_ChIP-Seq_A2780_Human1.51990488
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49552731
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49502394
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.46794382
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.46188222
42AR_25329375_ChIP-Seq_VCAP_Human1.40678779
43RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.39006899
44EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38893591
45PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.38662451
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.37872302
47FUS_26573619_Chip-Seq_HEK293_Human1.33763037
48* STAT3_23295773_ChIP-Seq_U87_Human1.31780163
49NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31650940
50SOX2_21211035_ChIP-Seq_LN229_Gbm1.31128654
51EP300_21415370_ChIP-Seq_HL-1_Mouse1.30868753
52ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30480278
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.29361327
54ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.27880426
55* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.26694282
56TCF4_23295773_ChIP-Seq_U87_Human1.26184291
57BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24955816
58AR_19668381_ChIP-Seq_PC3_Human1.24287795
59RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.24140930
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23001773
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.22898992
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22533790
63P300_19829295_ChIP-Seq_ESCs_Human1.22147402
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20897145
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13238203
66WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12570370
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11756696
68YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10979899
69RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10890811
70TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10650199
71AR_21909140_ChIP-Seq_LNCAP_Human1.08316883
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07803284
73CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06723129
74TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06275191
75GATA1_26923725_Chip-Seq_HPCs_Mouse1.04589801
76LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04508216
77HTT_18923047_ChIP-ChIP_STHdh_Human1.04045559
78ESR2_21235772_ChIP-Seq_MCF-7_Human1.03500781
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03027478
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02930448
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02930448
82PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.01825420
83BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00123660
84NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.99387089
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99276025
86SMAD4_21741376_ChIP-Seq_HESCs_Human0.98511835
87* RUNX2_22187159_ChIP-Seq_PCA_Human0.98332625
88ESR1_20079471_ChIP-ChIP_T-47D_Human0.95691180
89ISL1_27105846_Chip-Seq_CPCs_Mouse0.95655107
90* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95277234
91* FOXA2_19822575_ChIP-Seq_HepG2_Human0.95274042
92SOX9_26525672_Chip-Seq_HEART_Mouse0.95045396
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94843145
94SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94227941
95RING1B_27294783_Chip-Seq_NPCs_Mouse0.93987669
96ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.93209095
97P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92211763
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91177466
99MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87920519
100STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.87556592

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.41962282
2MP0004859_abnormal_synaptic_plasticity4.34731346
3MP0004270_analgesia3.55795966
4MP0004145_abnormal_muscle_electrophysio3.16652080
5MP0005423_abnormal_somatic_nervous2.89545441
6MP0003635_abnormal_synaptic_transmissio2.85479471
7MP0002064_seizures2.61365880
8MP0009046_muscle_twitch2.58244420
9MP0009745_abnormal_behavioral_response2.57919719
10MP0001486_abnormal_startle_reflex2.55491333
11MP0002272_abnormal_nervous_system2.39156791
12MP0002734_abnormal_mechanical_nocicepti2.25660876
13MP0002063_abnormal_learning/memory/cond2.23720433
14MP0002009_preneoplasia2.16651540
15MP0001968_abnormal_touch/_nociception2.12720667
16MP0003879_abnormal_hair_cell2.07002410
17MP0002572_abnormal_emotion/affect_behav1.95618073
18MP0002735_abnormal_chemical_nociception1.84222305
19MP0000751_myopathy1.81109246
20MP0005646_abnormal_pituitary_gland1.79315634
21MP0000537_abnormal_urethra_morphology1.78140446
22MP0002822_catalepsy1.74958634
23MP0004036_abnormal_muscle_relaxation1.72267967
24MP0002736_abnormal_nociception_after1.72011689
25MP0001501_abnormal_sleep_pattern1.67566909
26MP0002234_abnormal_pharynx_morphology1.63840414
27MP0008569_lethality_at_weaning1.61783974
28MP0001984_abnormal_olfaction1.60162374
29MP0002067_abnormal_sensory_capabilities1.52363636
30MP0003122_maternal_imprinting1.48339406
31MP0002557_abnormal_social/conspecific_i1.47828759
32MP0001346_abnormal_lacrimal_gland1.45614057
33MP0003646_muscle_fatigue1.43683327
34MP0005187_abnormal_penis_morphology1.41379093
35MP0006276_abnormal_autonomic_nervous1.35370874
36MP0009780_abnormal_chondrocyte_physiolo1.33406358
37MP0003315_abnormal_perineum_morphology1.31024585
38MP0005645_abnormal_hypothalamus_physiol1.30752444
39MP0001440_abnormal_grooming_behavior1.29149761
40MP0002733_abnormal_thermal_nociception1.26535303
41MP0004215_abnormal_myocardial_fiber1.24482227
42MP0005386_behavior/neurological_phenoty1.22622579
43MP0004924_abnormal_behavior1.22622579
44MP0001970_abnormal_pain_threshold1.21682861
45MP0000778_abnormal_nervous_system1.19296148
46MP0005551_abnormal_eye_electrophysiolog1.18511761
47MP0004084_abnormal_cardiac_muscle1.16627213
48MP0003633_abnormal_nervous_system1.15853692
49MP0002066_abnormal_motor_capabilities/c1.14879373
50MP0003283_abnormal_digestive_organ1.13105156
51MP0000566_synostosis1.11944512
52MP0000749_muscle_degeneration1.09737675
53MP0001502_abnormal_circadian_rhythm1.09657392
54MP0000955_abnormal_spinal_cord1.08204274
55MP0000747_muscle_weakness1.06932022
56MP0001529_abnormal_vocalization1.00816900
57MP0005085_abnormal_gallbladder_physiolo1.00616471
58MP0004085_abnormal_heartbeat0.99907154
59MP0002184_abnormal_innervation0.99392490
60MP0002882_abnormal_neuron_morphology0.98573344
61MP0003137_abnormal_impulse_conducting0.98420385
62MP0006292_abnormal_olfactory_placode0.97753790
63MP0003787_abnormal_imprinting0.96797764
64MP0001485_abnormal_pinna_reflex0.96646076
65MP0004811_abnormal_neuron_physiology0.96486248
66MP0008875_abnormal_xenobiotic_pharmacok0.95034460
67MP0003690_abnormal_glial_cell0.94915194
68MP0003631_nervous_system_phenotype0.94859223
69MP0002837_dystrophic_cardiac_calcinosis0.93202220
70MP0000631_abnormal_neuroendocrine_gland0.91789631
71MP0001177_atelectasis0.90007505
72MP0004087_abnormal_muscle_fiber0.86200899
73MP0002152_abnormal_brain_morphology0.85920925
74MP0004742_abnormal_vestibular_system0.85292746
75MP0002229_neurodegeneration0.84350410
76MP0001963_abnormal_hearing_physiology0.84244178
77MP0004043_abnormal_pH_regulation0.83026100
78MP0002269_muscular_atrophy0.82987479
79MP0000920_abnormal_myelination0.81242969
80MP0005620_abnormal_muscle_contractility0.80033856
81MP0008995_early_reproductive_senescence0.79952922
82MP0008775_abnormal_heart_ventricle0.79940283
83MP0004130_abnormal_muscle_cell0.79629346
84MP0001986_abnormal_taste_sensitivity0.78311240
85MP0008877_abnormal_DNA_methylation0.78149820
86MP0001299_abnormal_eye_distance/0.77559839
87MP0003123_paternal_imprinting0.75974177
88MP0004782_abnormal_surfactant_physiolog0.74434704
89MP0003890_abnormal_embryonic-extraembry0.73490907
90MP0003698_abnormal_male_reproductive0.71792267
91MP0002249_abnormal_larynx_morphology0.70331598
92MP0003329_amyloid_beta_deposits0.68456869
93MP0002106_abnormal_muscle_physiology0.66431030
94MP0002090_abnormal_vision0.65698510
95MP0004484_altered_response_of0.64156757
96MP0005369_muscle_phenotype0.62774045
97MP0004133_heterotaxia0.61717253
98MP0000534_abnormal_ureter_morphology0.60809669
99MP0000383_abnormal_hair_follicle0.60418358
100MP0002972_abnormal_cardiac_muscle0.59794030

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.35790314
2Focal motor seizures (HP:0011153)5.80761441
3Febrile seizures (HP:0002373)4.65043246
4Focal seizures (HP:0007359)4.41285809
5Calf muscle hypertrophy (HP:0008981)4.40378462
6Action tremor (HP:0002345)4.28982611
7Atonic seizures (HP:0010819)4.25422164
8Muscle hypertrophy of the lower extremities (HP:0008968)4.17176478
9Epileptic encephalopathy (HP:0200134)3.71786693
10Exercise-induced muscle cramps (HP:0003710)3.41510282
11Gonadotropin excess (HP:0000837)3.31381319
12Generalized tonic-clonic seizures (HP:0002069)3.26682211
13Muscle fiber inclusion bodies (HP:0100299)3.18969230
14Nemaline bodies (HP:0003798)3.12932862
15Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.12340121
16Absence seizures (HP:0002121)3.07381682
17Dialeptic seizures (HP:0011146)2.94452031
18Progressive cerebellar ataxia (HP:0002073)2.93605058
19Status epilepticus (HP:0002133)2.91037418
20Bundle branch block (HP:0011710)2.86158389
21Dysmetric saccades (HP:0000641)2.75578221
22Dysdiadochokinesis (HP:0002075)2.75360110
23Gaze-evoked nystagmus (HP:0000640)2.75074243
24Abnormality of the calf musculature (HP:0001430)2.61875733
25Ankle clonus (HP:0011448)2.55037215
26Urinary bladder sphincter dysfunction (HP:0002839)2.51502046
27Postural instability (HP:0002172)2.49734196
28Papilledema (HP:0001085)2.44701873
29Abnormality of the lower motor neuron (HP:0002366)2.41413504
30Exercise-induced myalgia (HP:0003738)2.41264429
31Dysmetria (HP:0001310)2.40972406
32Bifid scrotum (HP:0000048)2.40357974
33Testicular atrophy (HP:0000029)2.38090582
34Sudden death (HP:0001699)2.35625823
35Urinary urgency (HP:0000012)2.32159586
36Spastic gait (HP:0002064)2.30089467
37Testicular neoplasm (HP:0010788)2.28896976
38Poor eye contact (HP:0000817)2.26430034
39Impaired vibration sensation in the lower limbs (HP:0002166)2.19553703
40Heart block (HP:0012722)2.18394968
41Abnormality of the corticospinal tract (HP:0002492)2.17103674
42Intention tremor (HP:0002080)2.14183704
43Supranuclear gaze palsy (HP:0000605)2.09029720
44Hyperventilation (HP:0002883)2.07828862
45Degeneration of the lateral corticospinal tracts (HP:0002314)2.06758500
46Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.06758500
47Depression (HP:0000716)2.04254443
48Anxiety (HP:0000739)2.03786057
49Hyporeflexia of lower limbs (HP:0002600)2.00266194
50Abnormal social behavior (HP:0012433)1.99368430
51Impaired social interactions (HP:0000735)1.99368430
52Epileptiform EEG discharges (HP:0011182)1.95957865
53Abnormality of binocular vision (HP:0011514)1.94741480
54Diplopia (HP:0000651)1.94741480
55Deep venous thrombosis (HP:0002625)1.93311559
56Lower limb muscle weakness (HP:0007340)1.90741101
57Genetic anticipation (HP:0003743)1.90605530
58Scanning speech (HP:0002168)1.89998796
59Impaired vibratory sensation (HP:0002495)1.88873950
60Abnormal atrioventricular conduction (HP:0005150)1.86967213
61Incomplete penetrance (HP:0003829)1.85545498
62Impaired smooth pursuit (HP:0007772)1.85453489
63Fetal akinesia sequence (HP:0001989)1.83540321
64Tetraplegia (HP:0002445)1.82875812
65Morphological abnormality of the pyramidal tract (HP:0002062)1.82783570
66Hyperkalemia (HP:0002153)1.82706981
67Obstructive sleep apnea (HP:0002870)1.81654240
68Abnormal eating behavior (HP:0100738)1.80848903
69Abnormality of the left ventricular outflow tract (HP:0011103)1.79973352
70Subaortic stenosis (HP:0001682)1.79973352
71Broad-based gait (HP:0002136)1.79873517
72Amblyopia (HP:0000646)1.79541282
73Muscle fiber splitting (HP:0003555)1.79241260
74Torticollis (HP:0000473)1.76299404
75Prostate neoplasm (HP:0100787)1.75046069
76Hemiparesis (HP:0001269)1.73403432
77Limb dystonia (HP:0002451)1.72929919
78EEG with generalized epileptiform discharges (HP:0011198)1.72709197
79Abnormality of aromatic amino acid family metabolism (HP:0004338)1.70711519
80Gait imbalance (HP:0002141)1.69736045
81Hyperpituitarism (HP:0010514)1.68084828
82Atrioventricular block (HP:0001678)1.67633136
83Rimmed vacuoles (HP:0003805)1.67200351
84Bronchomalacia (HP:0002780)1.67005180
85Azoospermia (HP:0000027)1.66839908
86EMG: myopathic abnormalities (HP:0003458)1.66679063
87Syncope (HP:0001279)1.66255338
88Cerebral inclusion bodies (HP:0100314)1.65605610
89Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.65289361
90Annular pancreas (HP:0001734)1.65134441
91Hypsarrhythmia (HP:0002521)1.64554727
92Drooling (HP:0002307)1.64224697
93Type 1 muscle fiber predominance (HP:0003803)1.63681341
94Bradykinesia (HP:0002067)1.63540891
95Atrial fibrillation (HP:0005110)1.63359955
96Cerebral hypomyelination (HP:0006808)1.61521884
97Neurofibrillary tangles (HP:0002185)1.61096475
98Clonus (HP:0002169)1.59007574
99Complement deficiency (HP:0004431)1.57440591
100Prolonged partial thromboplastin time (HP:0003645)1.57033426

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.91429112
2TNK23.49231610
3NTRK33.04957858
4DAPK23.03479670
5OBSCN3.01293016
6MARK12.72591725
7CAMK1G2.37902000
8PAK62.13837785
9CAMK1D2.10679526
10PRKD32.10400735
11UHMK11.86043041
12MINK11.82003734
13MAP3K91.80561888
14AKT31.74757197
15NTRK21.72880760
16PHKG21.68374032
17PHKG11.68374032
18PLK21.66506039
19CAMK11.66169017
20CDK191.63723095
21PINK11.56279558
22FER1.54408638
23CAMKK11.50436044
24MAPK131.46288372
25CAMKK21.42891400
26CASK1.35775210
27SGK2231.34968921
28SGK4941.34968921
29PNCK1.34171584
30LATS21.29985089
31MARK21.29169115
32CDK51.22072689
33SGK21.20295482
34CAMK2B1.20291913
35ARAF1.18086840
36CCNB11.17188148
37CAMK41.14652568
38STK391.13753822
39PRKCG1.04565150
40SGK31.02875716
41CAMK2A1.01462994
42PAK31.00885575
43DAPK10.96936176
44EEF2K0.96267976
45NTRK10.93173668
46BRSK10.92033108
47STK110.90798869
48WNK10.87789982
49OXSR10.86403671
50BRAF0.81856683
51SGK10.80369974
52STK380.79603151
53GRK50.79374809
54MAP2K40.78146529
55CDK150.77789280
56CDK180.77459999
57CAMK2G0.76091366
58MAP3K40.75457600
59WNK30.73633365
60PKN10.73228207
61CDK11A0.71966053
62WNK40.70973145
63DYRK1A0.68066449
64BCR0.67580646
65RAF10.67348312
66RPS6KA30.65404621
67NEK60.65158145
68MAPK100.63956576
69TAOK10.63736820
70MAPK120.62748989
71DMPK0.60988437
72CDK140.60827489
73CAMK2D0.60793287
74MAP3K70.56989544
75PRKCZ0.55317507
76PRKAA10.54809513
77FGFR20.54471824
78PIK3CA0.54449960
79PDK10.52595601
80PRKCH0.51507015
81MET0.51019321
82PDPK10.49943265
83RIPK10.47902811
84ICK0.47848692
85MAP3K120.47763090
86ERBB30.46972537
87AKT20.46458270
88KSR20.43718519
89LIMK10.43229509
90BMPR1B0.43192355
91PRKG10.42833200
92PRKCE0.42234612
93STK38L0.42065638
94PRKAA20.41652048
95PRKACA0.39791896
96DAPK30.37737782
97TESK10.34061469
98TYRO30.33306140
99TNIK0.32975541
100INSRR0.32582309

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.23469733
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.70693262
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.47092139
4Synaptic vesicle cycle_Homo sapiens_hsa047212.41134925
5Long-term potentiation_Homo sapiens_hsa047202.23509341
6GABAergic synapse_Homo sapiens_hsa047272.06933289
7Circadian entrainment_Homo sapiens_hsa047132.04189791
8Amphetamine addiction_Homo sapiens_hsa050312.03124275
9Fatty acid biosynthesis_Homo sapiens_hsa000611.93704804
10Glutamatergic synapse_Homo sapiens_hsa047241.91584245
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.88237548
12Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.85398112
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.84927362
14Arginine biosynthesis_Homo sapiens_hsa002201.75501551
15Insulin secretion_Homo sapiens_hsa049111.72773637
16Morphine addiction_Homo sapiens_hsa050321.70918349
17Vitamin B6 metabolism_Homo sapiens_hsa007501.67975514
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.60711731
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58810141
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.58392453
21Dopaminergic synapse_Homo sapiens_hsa047281.56094905
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.49999211
23Gastric acid secretion_Homo sapiens_hsa049711.47052173
24Bile secretion_Homo sapiens_hsa049761.40607188
25Arginine and proline metabolism_Homo sapiens_hsa003301.40533130
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.39198129
27Circadian rhythm_Homo sapiens_hsa047101.34788546
28Salivary secretion_Homo sapiens_hsa049701.32954567
29Propanoate metabolism_Homo sapiens_hsa006401.32093713
30Oxytocin signaling pathway_Homo sapiens_hsa049211.31733212
31Calcium signaling pathway_Homo sapiens_hsa040201.31546911
32Cardiac muscle contraction_Homo sapiens_hsa042601.31309624
33Phenylalanine metabolism_Homo sapiens_hsa003601.23810522
34Cocaine addiction_Homo sapiens_hsa050301.21846605
35Cholinergic synapse_Homo sapiens_hsa047251.15470742
36Renin secretion_Homo sapiens_hsa049241.15381336
37Pyruvate metabolism_Homo sapiens_hsa006201.14734164
38Fatty acid degradation_Homo sapiens_hsa000711.12493991
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.12109934
40Histidine metabolism_Homo sapiens_hsa003401.11701529
41Taste transduction_Homo sapiens_hsa047421.11455593
42Glucagon signaling pathway_Homo sapiens_hsa049221.10025389
43Serotonergic synapse_Homo sapiens_hsa047261.06016729
44Butanoate metabolism_Homo sapiens_hsa006501.04785500
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03135527
46beta-Alanine metabolism_Homo sapiens_hsa004101.00079092
47Dilated cardiomyopathy_Homo sapiens_hsa054140.99944113
48Olfactory transduction_Homo sapiens_hsa047400.98484596
49Oocyte meiosis_Homo sapiens_hsa041140.97387880
50Long-term depression_Homo sapiens_hsa047300.97325724
51cAMP signaling pathway_Homo sapiens_hsa040240.96395991
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95117227
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93312650
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.92480081
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89420597
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.87121129
57Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.86490719
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.86076337
59Biosynthesis of amino acids_Homo sapiens_hsa012300.81437574
60Fatty acid metabolism_Homo sapiens_hsa012120.79970769
61Carbon metabolism_Homo sapiens_hsa012000.78414005
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.75234223
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75112740
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.74427784
65Complement and coagulation cascades_Homo sapiens_hsa046100.74156561
66GnRH signaling pathway_Homo sapiens_hsa049120.73205305
67Thyroid hormone synthesis_Homo sapiens_hsa049180.72709082
68Gap junction_Homo sapiens_hsa045400.72368154
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71968917
70Tryptophan metabolism_Homo sapiens_hsa003800.71779504
71Tyrosine metabolism_Homo sapiens_hsa003500.70861349
72Melanogenesis_Homo sapiens_hsa049160.70643600
73Nitrogen metabolism_Homo sapiens_hsa009100.67731025
74Retinol metabolism_Homo sapiens_hsa008300.66506342
75Pancreatic secretion_Homo sapiens_hsa049720.65856491
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63219131
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61008094
78Tight junction_Homo sapiens_hsa045300.60677210
79Caffeine metabolism_Homo sapiens_hsa002320.60201288
80Estrogen signaling pathway_Homo sapiens_hsa049150.59191049
81ABC transporters_Homo sapiens_hsa020100.58605613
82Peroxisome_Homo sapiens_hsa041460.58182063
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55511467
84Insulin signaling pathway_Homo sapiens_hsa049100.53359718
85Prion diseases_Homo sapiens_hsa050200.53199630
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52827396
87Lysine degradation_Homo sapiens_hsa003100.52321060
88Phototransduction_Homo sapiens_hsa047440.50878551
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49824974
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49639496
91Mineral absorption_Homo sapiens_hsa049780.49613139
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49472060
93AMPK signaling pathway_Homo sapiens_hsa041520.49065652
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47547076
95Chemical carcinogenesis_Homo sapiens_hsa052040.47321663
96PPAR signaling pathway_Homo sapiens_hsa033200.46774595
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46431084
98Axon guidance_Homo sapiens_hsa043600.46372769
99Linoleic acid metabolism_Homo sapiens_hsa005910.46084671
100Glioma_Homo sapiens_hsa052140.44933663

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