ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	4.96430251
2	behavioral response to nicotine (GO:0035095)	4.74240759
3	cellular ketone body metabolic process (GO:0046950)	4.50519109
4	protein polyglutamylation (GO:0018095)	4.17755662
5	ketone body metabolic process (GO:1902224)	4.04031265
6	L-fucose catabolic process (GO:0042355)	4.01402122
7	fucose catabolic process (GO:0019317)	4.01402122
8	L-fucose metabolic process (GO:0042354)	4.01402122
9	indole-containing compound catabolic process (GO:0042436)	3.95358595
10	indolalkylamine catabolic process (GO:0046218)	3.95358595
11	tryptophan catabolic process (GO:0006569)	3.95358595
12	sperm motility (GO:0030317)	3.80639764
13	indolalkylamine metabolic process (GO:0006586)	3.74860402
14	kynurenine metabolic process (GO:0070189)	3.70237787
15	axoneme assembly (GO:0035082)	3.69317222
16	DNA deamination (GO:0045006)	3.62916167
17	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.62253537
18	detection of light stimulus involved in sensory perception (GO:0050962)	3.60381127
19	detection of light stimulus involved in visual perception (GO:0050908)	3.60381127
20	cilium or flagellum-dependent cell motility (GO:0001539)	3.50607555
21	regulation of cilium movement (GO:0003352)	3.49482179
22	piRNA metabolic process (GO:0034587)	3.41037451
23	tryptophan metabolic process (GO:0006568)	3.40564401
24	multicellular organism reproduction (GO:0032504)	3.31720386
25	preassembly of GPI anchor in ER membrane (GO:0016254)	3.31466893
26	acrosome reaction (GO:0007340)	3.31406283
27	retinal cone cell development (GO:0046549)	3.27284859
28	DNA double-strand break processing (GO:0000729)	3.25972684
29	water-soluble vitamin biosynthetic process (GO:0042364)	3.23735661
30	platelet dense granule organization (GO:0060155)	3.21847738
31	epithelial cilium movement (GO:0003351)	3.18689093
32	protein-cofactor linkage (GO:0018065)	3.15821700
33	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.05988131
34	DNA methylation involved in gamete generation (GO:0043046)	3.04961490
35	gamma-aminobutyric acid transport (GO:0015812)	3.04622802
36	photoreceptor cell maintenance (GO:0045494)	3.01647434
37	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.97138056
38	nonmotile primary cilium assembly (GO:0035058)	2.95902970
39	respiratory chain complex IV assembly (GO:0008535)	2.93789743
40	protein complex biogenesis (GO:0070271)	2.90699199
41	single strand break repair (GO:0000012)	2.88906579
42	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.88218190
43	NADH dehydrogenase complex assembly (GO:0010257)	2.85633934
44	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.85633934
45	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.85633934
46	indole-containing compound metabolic process (GO:0042430)	2.83805822
47	cellular biogenic amine catabolic process (GO:0042402)	2.79317216
48	amine catabolic process (GO:0009310)	2.79317216
49	spermatid development (GO:0007286)	2.77909594
50	reciprocal DNA recombination (GO:0035825)	2.74696517
51	reciprocal meiotic recombination (GO:0007131)	2.74696517
52	GPI anchor metabolic process (GO:0006505)	2.73849641
53	neuronal action potential propagation (GO:0019227)	2.73172060
54	cell wall macromolecule metabolic process (GO:0044036)	2.72390546
55	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.72310426
56	establishment of protein localization to Golgi (GO:0072600)	2.71977178
57	cilium movement (GO:0003341)	2.71940520
58	regulation of microtubule-based movement (GO:0060632)	2.71519153
59	NAD biosynthetic process (GO:0009435)	2.71395624
60	cytochrome complex assembly (GO:0017004)	2.71114938
61	auditory receptor cell stereocilium organization (GO:0060088)	2.70997459
62	mannosylation (GO:0097502)	2.69285699
63	rhodopsin mediated signaling pathway (GO:0016056)	2.67612643
64	cilium organization (GO:0044782)	2.66140802
65	replication fork processing (GO:0031297)	2.65914633
66	protein K11-linked deubiquitination (GO:0035871)	2.65735988
67	mitochondrial respiratory chain complex assembly (GO:0033108)	2.63530070
68	cilium morphogenesis (GO:0060271)	2.61993908
69	protein localization to cilium (GO:0061512)	2.61846726
70	C4-dicarboxylate transport (GO:0015740)	2.61391283
71	reflex (GO:0060004)	2.60195519
72	cell wall macromolecule catabolic process (GO:0016998)	2.59964732
73	neuronal action potential (GO:0019228)	2.59248366
74	cilium assembly (GO:0042384)	2.59052630
75	negative regulation of telomere maintenance (GO:0032205)	2.58570700
76	rRNA modification (GO:0000154)	2.58353537
77	organic cation transport (GO:0015695)	2.57233502
78	behavioral response to ethanol (GO:0048149)	2.56193008
79	synaptic transmission, cholinergic (GO:0007271)	2.55475488
80	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.54019395
81	rRNA methylation (GO:0031167)	2.53798929
82	L-methionine salvage (GO:0071267)	2.50379999
83	L-methionine biosynthetic process (GO:0071265)	2.50379999
84	amino acid salvage (GO:0043102)	2.50379999
85	cornea development in camera-type eye (GO:0061303)	2.50358536
86	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.49364707
87	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.49364707
88	primary amino compound metabolic process (GO:1901160)	2.49125307
89	recombinational repair (GO:0000725)	2.48041125
90	photoreceptor cell development (GO:0042461)	2.46359177
91	double-strand break repair via homologous recombination (GO:0000724)	2.46289665
92	proline transport (GO:0015824)	2.44437095
93	inositol phosphate catabolic process (GO:0071545)	2.43200591
94	calcium ion-dependent exocytosis (GO:0017156)	2.42224768
95	sulfation (GO:0051923)	2.40967542
96	seminiferous tubule development (GO:0072520)	2.40722757
97	neural tube formation (GO:0001841)	2.39825286
98	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.39752215
99	male meiosis I (GO:0007141)	2.39154915
100	pyrimidine nucleobase catabolic process (GO:0006208)	2.38071324

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.76831960
2	VDR_22108803_ChIP-Seq_LS180_Human	3.25656562
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.86071221
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.76441965
5	EZH2_22144423_ChIP-Seq_EOC_Human	2.76021442
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.54872705
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.36116010
8	FUS_26573619_Chip-Seq_HEK293_Human	2.27543642
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.26468903
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.23659172
11	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.18779410
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.16491246
13	EWS_26573619_Chip-Seq_HEK293_Human	2.07248516
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.04096555
15	P300_19829295_ChIP-Seq_ESCs_Human	1.99022236
16	TAF15_26573619_Chip-Seq_HEK293_Human	1.98393435
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.97919682
18	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.90361821
19	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.90215559
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.90176533
21	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.89646184
22	CBP_20019798_ChIP-Seq_JUKART_Human	1.76272300
23	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.76272300
24	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.74421097
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.60613569
26	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.60038127
27	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.57048267
28	TP53_22573176_ChIP-Seq_HFKS_Human	1.56549525
29	IRF1_19129219_ChIP-ChIP_H3396_Human	1.55030778
30	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.53782258
31	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.53782258
32	STAT3_23295773_ChIP-Seq_U87_Human	1.51386380
33	REST_21632747_ChIP-Seq_MESCs_Mouse	1.50501645
34	SMAD4_21799915_ChIP-Seq_A2780_Human	1.48815113
35	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.46569166
36	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.46119553
37	BCAT_22108803_ChIP-Seq_LS180_Human	1.43959618
38	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.41782086
39	NANOG_19829295_ChIP-Seq_ESCs_Human	1.41698790
40	SOX2_19829295_ChIP-Seq_ESCs_Human	1.41698790
41	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.41230592
42	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.39745813
43	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.39455466
44	AR_25329375_ChIP-Seq_VCAP_Human	1.39255297
45	TCF4_23295773_ChIP-Seq_U87_Human	1.39195067
46	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.34806342
47	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.33730770
48	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.33730770
49	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.32560443
50	TCF4_22108803_ChIP-Seq_LS180_Human	1.31912820
51	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.30899139
52	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.29179930
53	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.28711848
54	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.28330499
55	NCOR_22424771_ChIP-Seq_293T_Human	1.28097908
56	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.27422551
57	RUNX2_22187159_ChIP-Seq_PCA_Human	1.26873722
58	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.26378394
59	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.25560336
60	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.25196668
61	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.23546967
62	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.23395782
63	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.22646370
64	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.21196151
65	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.21187532
66	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.21096556
67	MYC_18940864_ChIP-ChIP_HL60_Human	1.21054967
68	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.18533840
69	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.18328742
70	RNF2_27304074_Chip-Seq_NSC_Mouse	1.17037001
71	HOXB7_26014856_ChIP-Seq_BT474_Human	1.16935693
72	MYC_19829295_ChIP-Seq_ESCs_Human	1.14858655
73	AR_20517297_ChIP-Seq_VCAP_Human	1.13023604
74	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.12934983
75	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.12910384
76	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.11798786
77	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.11792098
78	ERA_21632823_ChIP-Seq_H3396_Human	1.11709989
79	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.09101059
80	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.08552013
81	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.08533441
82	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.07040484
83	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.06522350
84	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.06506450
85	NANOG_20526341_ChIP-Seq_ESCs_Human	1.06412790
86	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.05904428
87	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.05706264
88	AR_21572438_ChIP-Seq_LNCaP_Human	1.05397895
89	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.05086125
90	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.04558272
91	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.03342683
92	TAF2_19829295_ChIP-Seq_ESCs_Human	1.01459171
93	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.00704193
94	CDX2_22108803_ChIP-Seq_LS180_Human	1.00163684
95	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.99268259
96	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.97161215
97	OCT4_20526341_ChIP-Seq_ESCs_Human	0.96690386
98	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.95291096
99	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.95051928
100	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95007108

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	2.78592411
2	MP0003787_abnormal_imprinting	2.62330833
3	MP0001968_abnormal_touch/_nociception	2.56529303
4	MP0005410_abnormal_fertilization	2.53615712
5	MP0005551_abnormal_eye_electrophysiolog	2.50173352
6	MP0006292_abnormal_olfactory_placode	2.33760814
7	MP0003646_muscle_fatigue	2.24745805
8	MP0009046_muscle_twitch	2.15593478
9	MP0003880_abnormal_central_pattern	2.08533760
10	MP0003195_calcinosis	2.03162090
11	MP0005646_abnormal_pituitary_gland	2.03039052
12	MP0001986_abnormal_taste_sensitivity	1.97458780
13	MP0008875_abnormal_xenobiotic_pharmacok	1.91160577
14	MP0002736_abnormal_nociception_after	1.91021939
15	MP0005645_abnormal_hypothalamus_physiol	1.89606113
16	MP0009745_abnormal_behavioral_response	1.86835241
17	MP0002837_dystrophic_cardiac_calcinosis	1.85829530
18	MP0005253_abnormal_eye_physiology	1.84704619
19	MP0006072_abnormal_retinal_apoptosis	1.83654632
20	MP0004043_abnormal_pH_regulation	1.81986493
21	MP0008872_abnormal_physiological_respon	1.81552458
22	MP0002272_abnormal_nervous_system	1.78088674
23	MP0006276_abnormal_autonomic_nervous	1.73811575
24	MP0001486_abnormal_startle_reflex	1.72993464
25	MP0001984_abnormal_olfaction	1.71646491
26	MP0002638_abnormal_pupillary_reflex	1.69891788
27	MP0005377_hearing/vestibular/ear_phenot	1.67102221
28	MP0003878_abnormal_ear_physiology	1.67102221
29	MP0003011_delayed_dark_adaptation	1.67100705
30	MP0001501_abnormal_sleep_pattern	1.65359261
31	MP0002876_abnormal_thyroid_physiology	1.60350886
32	MP0002102_abnormal_ear_morphology	1.55033147
33	MP0000372_irregular_coat_pigmentation	1.54259005
34	MP0001485_abnormal_pinna_reflex	1.54240384
35	MP0004142_abnormal_muscle_tone	1.53863226
36	MP0002234_abnormal_pharynx_morphology	1.48930077
37	MP0004147_increased_porphyrin_level	1.48153247
38	MP0002163_abnormal_gland_morphology	1.45623403
39	MP0000427_abnormal_hair_cycle	1.43439406
40	MP0005174_abnormal_tail_pigmentation	1.43294085
41	MP0004885_abnormal_endolymph	1.41581591
42	MP0002735_abnormal_chemical_nociception	1.39917734
43	MP0003698_abnormal_male_reproductive	1.39447350
44	MP0002653_abnormal_ependyma_morphology	1.38260343
45	MP0002572_abnormal_emotion/affect_behav	1.37343168
46	MP0003121_genomic_imprinting	1.36644996
47	MP0002138_abnormal_hepatobiliary_system	1.35313844
48	MP0000631_abnormal_neuroendocrine_gland	1.33081003
49	MP0002557_abnormal_social/conspecific_i	1.32616150
50	MP0000569_abnormal_digit_pigmentation	1.31890522
51	MP0005379_endocrine/exocrine_gland_phen	1.30216801
52	MP0005423_abnormal_somatic_nervous	1.29744366
53	MP0004145_abnormal_muscle_electrophysio	1.28890413
54	MP0002064_seizures	1.27129597
55	MP0002160_abnormal_reproductive_system	1.26253951
56	MP0003136_yellow_coat_color	1.24476435
57	MP0005084_abnormal_gallbladder_morpholo	1.23260196
58	MP0003635_abnormal_synaptic_transmissio	1.23150725
59	MP0001970_abnormal_pain_threshold	1.22532117
60	MP0001929_abnormal_gametogenesis	1.21539590
61	MP0001529_abnormal_vocalization	1.20212131
62	MP0003718_maternal_effect	1.18139413
63	MP0010386_abnormal_urinary_bladder	1.17239925
64	MP0002733_abnormal_thermal_nociception	1.16773630
65	MP0001764_abnormal_homeostasis	1.14961722
66	MP0004742_abnormal_vestibular_system	1.12053062
67	MP0002938_white_spotting	1.12037897
68	MP0003122_maternal_imprinting	1.11755315
69	MP0004133_heterotaxia	1.11168357
70	MP0002067_abnormal_sensory_capabilities	1.10941332
71	MP0008789_abnormal_olfactory_epithelium	1.07931466
72	MP0002063_abnormal_learning/memory/cond	1.07362387
73	MP0005075_abnormal_melanosome_morpholog	1.06298114
74	MP0001905_abnormal_dopamine_level	1.05640809
75	MP0005670_abnormal_white_adipose	1.04454328
76	MP0005389_reproductive_system_phenotype	1.03616541
77	MP0008995_early_reproductive_senescence	1.02598290
78	MP0002229_neurodegeneration	1.01625106
79	MP0005386_behavior/neurological_phenoty	1.01231128
80	MP0004924_abnormal_behavior	1.01231128
81	MP0002734_abnormal_mechanical_nocicepti	0.99595469
82	MP0005167_abnormal_blood-brain_barrier	0.99433603
83	MP0001502_abnormal_circadian_rhythm	0.98248372
84	MP0002822_catalepsy	0.93999110
85	MP0002928_abnormal_bile_duct	0.93869667
86	MP0008058_abnormal_DNA_repair	0.93603934
87	MP0001963_abnormal_hearing_physiology	0.92433763
88	MP0003137_abnormal_impulse_conducting	0.92243438
89	MP0002184_abnormal_innervation	0.91900077
90	MP0002210_abnormal_sex_determination	0.91830786
91	MP0005195_abnormal_posterior_eye	0.90834307
92	MP0002752_abnormal_somatic_nervous	0.89215152
93	MP0000230_abnormal_systemic_arterial	0.87121027
94	MP0000015_abnormal_ear_pigmentation	0.86831943
95	MP0002095_abnormal_skin_pigmentation	0.86317582
96	MP0000653_abnormal_sex_gland	0.84071664
97	MP0008775_abnormal_heart_ventricle	0.83127885
98	MP0005499_abnormal_olfactory_system	0.82680890
99	MP0005394_taste/olfaction_phenotype	0.82680890
100	MP0004215_abnormal_myocardial_fiber	0.82253269

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.27652605
2	Pancreatic fibrosis (HP:0100732)	3.96460330
3	Chronic hepatic failure (HP:0100626)	3.89347498
4	Congenital stationary night blindness (HP:0007642)	3.78889175
5	Molar tooth sign on MRI (HP:0002419)	3.76794259
6	Abnormality of midbrain morphology (HP:0002418)	3.76794259
7	True hermaphroditism (HP:0010459)	3.73036107
8	Attenuation of retinal blood vessels (HP:0007843)	3.68189803
9	Nephronophthisis (HP:0000090)	3.62996478
10	Abnormality of the renal medulla (HP:0100957)	3.22994209
11	Abnormal rod and cone electroretinograms (HP:0008323)	3.09921674
12	Abnormality of the renal cortex (HP:0011035)	3.02071677
13	Medial flaring of the eyebrow (HP:0010747)	3.01264611
14	Type II lissencephaly (HP:0007260)	2.96205739
15	Abolished electroretinogram (ERG) (HP:0000550)	2.95025804
16	Decreased central vision (HP:0007663)	2.74974765
17	Cystic liver disease (HP:0006706)	2.71751180
18	Pendular nystagmus (HP:0012043)	2.69113867
19	Bony spicule pigmentary retinopathy (HP:0007737)	2.67975636
20	Gaze-evoked nystagmus (HP:0000640)	2.64542697
21	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.59096986
22	Polydipsia (HP:0001959)	2.50872512
23	Abnormal drinking behavior (HP:0030082)	2.50872512
24	Progressive cerebellar ataxia (HP:0002073)	2.50330381
25	Gait imbalance (HP:0002141)	2.45137963
26	Tubular atrophy (HP:0000092)	2.44786829
27	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.44199102
28	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.42989147
29	Abnormality of alanine metabolism (HP:0010916)	2.42989147
30	Hyperalaninemia (HP:0003348)	2.42989147
31	Hyperventilation (HP:0002883)	2.41509900
32	Sclerocornea (HP:0000647)	2.38278408
33	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.38274738
34	Absent/shortened dynein arms (HP:0200106)	2.38274738
35	Hyperglycinemia (HP:0002154)	2.38050158
36	Congenital primary aphakia (HP:0007707)	2.36235718
37	Methylmalonic acidemia (HP:0002912)	2.34451413
38	Nephrogenic diabetes insipidus (HP:0009806)	2.34330026
39	Febrile seizures (HP:0002373)	2.28086361
40	Lissencephaly (HP:0001339)	2.25756584
41	Hyperglycinuria (HP:0003108)	2.23854994
42	Increased corneal curvature (HP:0100692)	2.22758430
43	Keratoconus (HP:0000563)	2.22758430
44	Abnormal respiratory epithelium morphology (HP:0012253)	2.22436455
45	Abnormal respiratory motile cilium morphology (HP:0005938)	2.22436455
46	Abnormal biliary tract physiology (HP:0012439)	2.19306094
47	Bile duct proliferation (HP:0001408)	2.19306094
48	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.19241007
49	Congenital hepatic fibrosis (HP:0002612)	2.18845527
50	Cerebellar dysplasia (HP:0007033)	2.17790772
51	Polyuria (HP:0000103)	2.17532569
52	Broad-based gait (HP:0002136)	2.15715331
53	Inability to walk (HP:0002540)	2.15131321
54	Methylmalonic aciduria (HP:0012120)	2.13980816
55	Abnormality of macular pigmentation (HP:0008002)	2.13387375
56	Anencephaly (HP:0002323)	2.10915001
57	Ketosis (HP:0001946)	2.09944514
58	Tubulointerstitial nephritis (HP:0001970)	2.07682172
59	3-Methylglutaconic aciduria (HP:0003535)	2.04739697
60	Abnormality of the labia minora (HP:0012880)	2.03801665
61	Genital tract atresia (HP:0001827)	2.01817530
62	Acute necrotizing encephalopathy (HP:0006965)	2.00977893
63	Decreased circulating renin level (HP:0003351)	1.99534912
64	Retinal dysplasia (HP:0007973)	1.99182405
65	Abnormality of glycine metabolism (HP:0010895)	1.98679670
66	Abnormality of serine family amino acid metabolism (HP:0010894)	1.98679670
67	Renal cortical cysts (HP:0000803)	1.97503975
68	Constricted visual fields (HP:0001133)	1.97357291
69	Genetic anticipation (HP:0003743)	1.97280606
70	Congenital sensorineural hearing impairment (HP:0008527)	1.97165259
71	Optic nerve hypoplasia (HP:0000609)	1.96202378
72	Acute encephalopathy (HP:0006846)	1.93103868
73	Vaginal atresia (HP:0000148)	1.92305493
74	Mitochondrial inheritance (HP:0001427)	1.92239827
75	Male pseudohermaphroditism (HP:0000037)	1.91784036
76	Chorioretinal atrophy (HP:0000533)	1.91592102
77	Postaxial foot polydactyly (HP:0001830)	1.90463376
78	Occipital encephalocele (HP:0002085)	1.88434992
79	Increased CSF lactate (HP:0002490)	1.88247519
80	Optic disc pallor (HP:0000543)	1.86870134
81	Ketoacidosis (HP:0001993)	1.86626520
82	Colon cancer (HP:0003003)	1.86427525
83	Large for gestational age (HP:0001520)	1.85953859
84	Progressive macrocephaly (HP:0004481)	1.85453615
85	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.85076761
86	Small hand (HP:0200055)	1.83963352
87	Abnormal ciliary motility (HP:0012262)	1.82836414
88	Furrowed tongue (HP:0000221)	1.82468181
89	Retinitis pigmentosa (HP:0000510)	1.81605016
90	Abnormal urine output (HP:0012590)	1.80491822
91	Poor coordination (HP:0002370)	1.78515026
92	Hemiparesis (HP:0001269)	1.76850702
93	Focal motor seizures (HP:0011153)	1.75763443
94	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.74181345
95	Hepatocellular necrosis (HP:0001404)	1.74066905
96	Progressive inability to walk (HP:0002505)	1.73127259
97	Hypothermia (HP:0002045)	1.72460949
98	Thyroid-stimulating hormone excess (HP:0002925)	1.71284306
99	Hepatic necrosis (HP:0002605)	1.68304832
100	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.67487520

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.11543366
2	MAP4K2	3.66036853
3	BMPR1B	2.89891260
4	ADRBK2	2.85339075
5	NUAK1	2.67242901
6	PINK1	2.59362739
7	WNK3	2.57281324
8	ZAK	2.26159627
9	WNK4	2.01928254
10	INSRR	1.98301608
11	GRK1	1.97890705
12	MAPK13	1.79135460
13	ACVR1B	1.77681526
14	TRIM28	1.75427189
15	TAOK3	1.72753688
16	CASK	1.71439780
17	OXSR1	1.68417228
18	BCKDK	1.63876743
19	MAP3K4	1.62695340
20	STK39	1.56813823
21	TLK1	1.51151825
22	STK38L	1.47547226
23	PLK4	1.42528596
24	DAPK2	1.35457893
25	DYRK2	1.28307604
26	TXK	1.28141884
27	PLK2	1.27540242
28	PHKG1	1.26544731
29	PHKG2	1.26544731
30	MKNK2	1.24460089
31	MAP2K6	1.11779412
32	TIE1	1.08978494
33	MARK1	1.04431994
34	FGFR2	1.03928000
35	PRKCE	0.96709238
36	CDK19	0.96066349
37	TAF1	0.95490577
38	PAK3	0.95420518
39	MAP2K7	0.95020381
40	CSNK1G3	0.94630599
41	PRKCG	0.94602720
42	EPHA4	0.93435209
43	CSNK1G2	0.92542993
44	ADRBK1	0.91693963
45	BCR	0.90572231
46	STK16	0.90041353
47	CSNK1G1	0.88834183
48	NTRK3	0.87267101
49	VRK1	0.85228723
50	MUSK	0.82509127
51	TNIK	0.80101533
52	CSNK1A1L	0.78706652
53	VRK2	0.73662154
54	MAPK15	0.72809160
55	EIF2AK3	0.72611011
56	OBSCN	0.70120825
57	ERBB3	0.66484016
58	TEC	0.65268893
59	CAMKK2	0.64688483
60	NME1	0.64532120
61	MKNK1	0.63811916
62	MINK1	0.63044314
63	TGFBR1	0.62882370
64	KIT	0.62819178
65	FER	0.60533730
66	TNK2	0.59589941
67	PTK2B	0.57299264
68	NTRK2	0.55810551
69	GRK5	0.52579179
70	PKN1	0.51762732
71	PRKCQ	0.51477281
72	PLK3	0.51369210
73	CSNK1A1	0.50882801
74	FLT3	0.49141416
75	CAMK2A	0.48193190
76	PRKACA	0.47025737
77	IKBKB	0.46772879
78	STK11	0.46381820
79	CAMK1	0.46073491
80	STK3	0.40774958
81	PIK3CA	0.40766546
82	MST4	0.40627902
83	PRKAA1	0.39648434
84	PRKCI	0.39051258
85	ITK	0.38418980
86	RPS6KA5	0.37597272
87	SGK223	0.37569471
88	SGK494	0.37569471
89	NEK2	0.37303461
90	PRKAA2	0.37231023
91	IRAK1	0.37051881
92	PIK3CG	0.36363436
93	PRKG1	0.35865175
94	CDK3	0.35476417
95	PRKCA	0.34948087
96	ATR	0.34804983
97	MAPKAPK5	0.33905656
98	CSNK1D	0.33742639
99	SGK2	0.33651058
100	BRSK2	0.33566768

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.35641837
2	Phototransduction_Homo sapiens_hsa04744	2.85101145
3	Butanoate metabolism_Homo sapiens_hsa00650	2.69748848
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.67069025
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.24431837
6	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.22677254
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.15667523
8	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.14421441
9	Nicotine addiction_Homo sapiens_hsa05033	2.13332054
10	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.98973856
11	Caffeine metabolism_Homo sapiens_hsa00232	1.98674348
12	Nitrogen metabolism_Homo sapiens_hsa00910	1.96103201
13	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.87339280
14	Homologous recombination_Homo sapiens_hsa03440	1.86865139
15	Selenocompound metabolism_Homo sapiens_hsa00450	1.85753569
16	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.83407621
17	Oxidative phosphorylation_Homo sapiens_hsa00190	1.82088384
18	Tryptophan metabolism_Homo sapiens_hsa00380	1.80275596
19	RNA polymerase_Homo sapiens_hsa03020	1.73588079
20	Olfactory transduction_Homo sapiens_hsa04740	1.72076918
21	Propanoate metabolism_Homo sapiens_hsa00640	1.71527840
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.65234829
23	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.64815187
24	Taste transduction_Homo sapiens_hsa04742	1.64469842
25	Basal transcription factors_Homo sapiens_hsa03022	1.55699996
26	Ether lipid metabolism_Homo sapiens_hsa00565	1.54711503
27	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.49848240
28	One carbon pool by folate_Homo sapiens_hsa00670	1.40182995
29	Morphine addiction_Homo sapiens_hsa05032	1.37511323
30	Protein export_Homo sapiens_hsa03060	1.35678605
31	Parkinsons disease_Homo sapiens_hsa05012	1.32910608
32	Peroxisome_Homo sapiens_hsa04146	1.31695733
33	Regulation of autophagy_Homo sapiens_hsa04140	1.21134312
34	GABAergic synapse_Homo sapiens_hsa04727	1.16668774
35	ABC transporters_Homo sapiens_hsa02010	1.15694845
36	RNA degradation_Homo sapiens_hsa03018	1.14725929
37	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.13944276
38	Circadian entrainment_Homo sapiens_hsa04713	1.11188768
39	Glutamatergic synapse_Homo sapiens_hsa04724	1.05935516
40	Huntingtons disease_Homo sapiens_hsa05016	1.02880627
41	Chemical carcinogenesis_Homo sapiens_hsa05204	1.01866138
42	Insulin secretion_Homo sapiens_hsa04911	1.01402974
43	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.98337006
44	Serotonergic synapse_Homo sapiens_hsa04726	0.97353993
45	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.97006318
46	Retinol metabolism_Homo sapiens_hsa00830	0.96948198
47	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.94614156
48	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.94518337
49	Cardiac muscle contraction_Homo sapiens_hsa04260	0.94462020
50	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.92225861
51	Sulfur relay system_Homo sapiens_hsa04122	0.91768747
52	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.91072750
53	beta-Alanine metabolism_Homo sapiens_hsa00410	0.89769962
54	Salivary secretion_Homo sapiens_hsa04970	0.88803334
55	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.87279073
56	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.86979045
57	Collecting duct acid secretion_Homo sapiens_hsa04966	0.85492174
58	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.85229836
59	Purine metabolism_Homo sapiens_hsa00230	0.85174535
60	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.84715229
61	Fatty acid degradation_Homo sapiens_hsa00071	0.84011773
62	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.83944196
63	Calcium signaling pathway_Homo sapiens_hsa04020	0.83512697
64	Alzheimers disease_Homo sapiens_hsa05010	0.81286858
65	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.78117457
66	Non-homologous end-joining_Homo sapiens_hsa03450	0.75727173
67	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.75541442
68	Metabolic pathways_Homo sapiens_hsa01100	0.74110729
69	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.69390589
70	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.68730551
71	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.68027543
72	Glycerolipid metabolism_Homo sapiens_hsa00561	0.67178854
73	Type I diabetes mellitus_Homo sapiens_hsa04940	0.65050542
74	Fatty acid metabolism_Homo sapiens_hsa01212	0.64165686
75	Fat digestion and absorption_Homo sapiens_hsa04975	0.62942096
76	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.59190259
77	Dopaminergic synapse_Homo sapiens_hsa04728	0.57793848
78	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.56727263
79	Pyrimidine metabolism_Homo sapiens_hsa00240	0.54692034
80	Arginine and proline metabolism_Homo sapiens_hsa00330	0.54576152
81	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.53125008
82	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.52584772
83	Circadian rhythm_Homo sapiens_hsa04710	0.51144445
84	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.50431135
85	Long-term depression_Homo sapiens_hsa04730	0.48184546
86	RNA transport_Homo sapiens_hsa03013	0.45261698
87	Histidine metabolism_Homo sapiens_hsa00340	0.43614597
88	Mineral absorption_Homo sapiens_hsa04978	0.43390212
89	Asthma_Homo sapiens_hsa05310	0.42769068
90	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.41097093
91	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.41030070
92	Proteasome_Homo sapiens_hsa03050	0.38871623
93	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.38858875
94	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.36859363
95	Lysine degradation_Homo sapiens_hsa00310	0.35979217
96	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.35935453
97	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.35358496
98	Base excision repair_Homo sapiens_hsa03410	0.35281119
99	Fatty acid elongation_Homo sapiens_hsa00062	0.34691973
100	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.34389035

ZNF385C

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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