ZNF385D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.67715278
2membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.54517947
3gamma-aminobutyric acid transport (GO:0015812)4.37756905
4serotonin metabolic process (GO:0042428)4.13567320
5ionotropic glutamate receptor signaling pathway (GO:0035235)4.08089061
6synaptic transmission, glutamatergic (GO:0035249)4.06242307
7membrane depolarization during action potential (GO:0086010)4.05279949
8neuronal action potential propagation (GO:0019227)3.94664294
9glutamate receptor signaling pathway (GO:0007215)3.90154240
10regulation of short-term neuronal synaptic plasticity (GO:0048172)3.84478289
11G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.82423556
12primary amino compound metabolic process (GO:1901160)3.78386972
13neuron-neuron synaptic transmission (GO:0007270)3.74790044
14neuronal action potential (GO:0019228)3.70373427
15postsynaptic membrane organization (GO:0001941)3.67363845
16neuron cell-cell adhesion (GO:0007158)3.59492177
17auditory behavior (GO:0031223)3.59442074
18regulation of synapse structural plasticity (GO:0051823)3.52232470
19gamma-aminobutyric acid signaling pathway (GO:0007214)3.50467086
20retinal cone cell development (GO:0046549)3.49958698
21transmission of nerve impulse (GO:0019226)3.47517695
22protein localization to synapse (GO:0035418)3.45057998
23presynaptic membrane assembly (GO:0097105)3.39724796
24pyrimidine nucleobase catabolic process (GO:0006208)3.33982977
25presynaptic membrane organization (GO:0097090)3.31380480
26startle response (GO:0001964)3.27579656
27adaptation of signaling pathway (GO:0023058)3.27229972
28vocalization behavior (GO:0071625)3.17803384
29cerebellar Purkinje cell differentiation (GO:0021702)3.17660685
30negative regulation of cytosolic calcium ion concentration (GO:0051481)3.14246994
31regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.10870785
32synaptic vesicle maturation (GO:0016188)3.07924251
33positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.06063058
34exploration behavior (GO:0035640)3.05202645
35mechanosensory behavior (GO:0007638)3.02793024
36regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.02533587
37positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.02443815
38synapse assembly (GO:0007416)2.99919162
39dopamine biosynthetic process (GO:0042416)2.98379888
40C4-dicarboxylate transport (GO:0015740)2.96854189
41short-term memory (GO:0007614)2.96670886
42membrane depolarization (GO:0051899)2.96416189
43neurotransmitter-gated ion channel clustering (GO:0072578)2.92741278
44neuromuscular synaptic transmission (GO:0007274)2.92636950
45regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.91428696
46adult walking behavior (GO:0007628)2.91319280
47cell differentiation in hindbrain (GO:0021533)2.90628900
48positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.90077935
49detection of light stimulus involved in sensory perception (GO:0050962)2.88298314
50detection of light stimulus involved in visual perception (GO:0050908)2.88298314
51cerebellar granule cell differentiation (GO:0021707)2.87627506
52behavioral response to ethanol (GO:0048149)2.86806006
53dendritic spine morphogenesis (GO:0060997)2.86609536
54reflex (GO:0060004)2.85030360
55indole-containing compound metabolic process (GO:0042430)2.81931491
56response to auditory stimulus (GO:0010996)2.80587792
57nucleobase catabolic process (GO:0046113)2.80457515
58neurofilament cytoskeleton organization (GO:0060052)2.77521366
59retina layer formation (GO:0010842)2.76887855
60adult behavior (GO:0030534)2.75947621
61locomotory exploration behavior (GO:0035641)2.74805124
62regulation of synaptic vesicle transport (GO:1902803)2.73974579
63glycerophospholipid catabolic process (GO:0046475)2.73015917
64negative regulation of synaptic transmission, GABAergic (GO:0032229)2.72846968
65action potential (GO:0001508)2.70938809
66detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.70588281
67synaptic vesicle exocytosis (GO:0016079)2.70437206
68proline transport (GO:0015824)2.70392407
69glutamate secretion (GO:0014047)2.70071717
70regulation of postsynaptic membrane potential (GO:0060078)2.69548267
71neuron recognition (GO:0008038)2.68050143
72neurotransmitter secretion (GO:0007269)2.67915731
73dopamine transport (GO:0015872)2.67134900
74regulation of excitatory postsynaptic membrane potential (GO:0060079)2.64143488
75axonal fasciculation (GO:0007413)2.64029948
76negative regulation of heart rate (GO:0010459)2.63230357
77regulation of synaptic transmission, glutamatergic (GO:0051966)2.63027227
78adult locomotory behavior (GO:0008344)2.60266104
79righting reflex (GO:0060013)2.59177850
80regulation of glutamate receptor signaling pathway (GO:1900449)2.59052458
81positive regulation of synapse assembly (GO:0051965)2.58966860
82positive regulation of potassium ion transmembrane transport (GO:1901381)2.58843000
83response to amphetamine (GO:0001975)2.58714988
84behavioral response to cocaine (GO:0048148)2.57047012
85protein polyglutamylation (GO:0018095)2.56656441
86tachykinin receptor signaling pathway (GO:0007217)2.55881169
87synaptic transmission, cholinergic (GO:0007271)2.54776152
88calcium ion-dependent exocytosis (GO:0017156)2.54542854
89synaptic transmission (GO:0007268)2.54064339
90response to pheromone (GO:0019236)2.53500504
91regulation of dopamine secretion (GO:0014059)2.52988064
92musculoskeletal movement (GO:0050881)2.52070053
93multicellular organismal movement (GO:0050879)2.52070053
94dendrite morphogenesis (GO:0048813)2.51965907
95negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.50872902
96protein neddylation (GO:0045116)2.48455644
97inner ear receptor stereocilium organization (GO:0060122)2.48156217
98urinary tract smooth muscle contraction (GO:0014848)2.47944299
99regulation of voltage-gated calcium channel activity (GO:1901385)2.46773019
100calcium ion import (GO:0070509)2.46718236

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.91933718
2GBX2_23144817_ChIP-Seq_PC3_Human3.95153887
3ZFP57_27257070_Chip-Seq_ESCs_Mouse2.67146384
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.65997583
5TAF15_26573619_Chip-Seq_HEK293_Human2.57353920
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.48002232
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.46006283
8VDR_22108803_ChIP-Seq_LS180_Human2.45830831
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.37682446
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.37119563
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.25752680
12ZNF274_21170338_ChIP-Seq_K562_Hela2.14766069
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.06318877
14REST_21632747_ChIP-Seq_MESCs_Mouse2.03637643
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02091532
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.00259084
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.00109690
18P300_19829295_ChIP-Seq_ESCs_Human1.99197598
19* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.93910657
20FUS_26573619_Chip-Seq_HEK293_Human1.93732513
21SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.92511595
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.92262373
23* SMAD4_21799915_ChIP-Seq_A2780_Human1.92249821
24IGF1R_20145208_ChIP-Seq_DFB_Human1.86633128
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.85063359
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.79920958
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.73292286
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.73073737
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.70448608
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.69271983
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.68098173
32EWS_26573619_Chip-Seq_HEK293_Human1.68037853
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.65763050
34SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.65409426
35SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.58403658
36SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.58082361
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.57057024
38UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56737456
39* STAT3_23295773_ChIP-Seq_U87_Human1.56695802
40RNF2_27304074_Chip-Seq_NSC_Mouse1.56538161
41OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55254999
42* AR_25329375_ChIP-Seq_VCAP_Human1.53803610
43TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53032516
44TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52434272
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.52434272
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.51983030
47DROSHA_22980978_ChIP-Seq_HELA_Human1.50921159
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50730062
49JARID2_20075857_ChIP-Seq_MESCs_Mouse1.49766460
50SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.48471396
51AR_21572438_ChIP-Seq_LNCaP_Human1.48017027
52BCAT_22108803_ChIP-Seq_LS180_Human1.47563114
53* TCF4_23295773_ChIP-Seq_U87_Human1.46121371
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.43589192
55SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.43266411
56REST_18959480_ChIP-ChIP_MESCs_Mouse1.41349520
57ER_23166858_ChIP-Seq_MCF-7_Human1.40660365
58NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40413845
59EZH2_27294783_Chip-Seq_ESCs_Mouse1.40027621
60EZH2_18974828_ChIP-Seq_MESCs_Mouse1.39626521
61RNF2_18974828_ChIP-Seq_MESCs_Mouse1.39626521
62MTF2_20144788_ChIP-Seq_MESCs_Mouse1.38340151
63SUZ12_27294783_Chip-Seq_ESCs_Mouse1.30580164
64RNF2_27304074_Chip-Seq_ESCs_Mouse1.30257958
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29287110
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.28331254
67SOX2_21211035_ChIP-Seq_LN229_Gbm1.26759626
68* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26725376
69* CBP_20019798_ChIP-Seq_JUKART_Human1.26725376
70TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26163126
71TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25889613
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24341989
73RUNX2_22187159_ChIP-Seq_PCA_Human1.23112993
74NANOG_18555785_Chip-Seq_ESCs_Mouse1.23042788
75RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19049022
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18958920
77PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18864821
78KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.18551037
79FLI1_21867929_ChIP-Seq_TH2_Mouse1.17147592
80* PRDM14_20953172_ChIP-Seq_ESCs_Human1.14681712
81CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13861988
82TAL1_26923725_Chip-Seq_HPCs_Mouse1.13763165
83RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13567443
84SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12176650
85MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11759393
86CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.10380680
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10090483
88LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09957192
89P53_22387025_ChIP-Seq_ESCs_Mouse1.09819924
90TCF4_22108803_ChIP-Seq_LS180_Human1.08377403
91* SMAD4_21741376_ChIP-Seq_EPCs_Human1.08041855
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06730732
93CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06539271
94KDM2B_26808549_Chip-Seq_REH_Human1.06438921
95EZH2_27294783_Chip-Seq_NPCs_Mouse1.06155165
96SALL1_21062744_ChIP-ChIP_HESCs_Human1.03363117
97TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02169520
98E2F1_18555785_Chip-Seq_ESCs_Mouse1.00806167
99NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00511118
100JUN_21703547_ChIP-Seq_K562_Human1.00503483

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.06386019
2MP0004859_abnormal_synaptic_plasticity3.10703557
3MP0009046_muscle_twitch3.04006643
4MP0001968_abnormal_touch/_nociception3.03511080
5MP0009745_abnormal_behavioral_response2.85741579
6MP0003635_abnormal_synaptic_transmissio2.80254582
7MP0002272_abnormal_nervous_system2.71184906
8MP0004270_analgesia2.58312040
9MP0002736_abnormal_nociception_after2.57965855
10MP0002064_seizures2.57447478
11MP0000569_abnormal_digit_pigmentation2.52604074
12MP0005423_abnormal_somatic_nervous2.39692259
13MP0001486_abnormal_startle_reflex2.39023732
14MP0002735_abnormal_chemical_nociception2.36423979
15MP0006276_abnormal_autonomic_nervous2.33105791
16MP0002063_abnormal_learning/memory/cond2.29551046
17MP0002572_abnormal_emotion/affect_behav2.24336087
18MP0002734_abnormal_mechanical_nocicepti2.17744468
19MP0005646_abnormal_pituitary_gland1.95434215
20MP0005551_abnormal_eye_electrophysiolog1.93702777
21MP0002733_abnormal_thermal_nociception1.91968083
22MP0002067_abnormal_sensory_capabilities1.91893606
23MP0002822_catalepsy1.90298872
24MP0001970_abnormal_pain_threshold1.90065240
25MP0001501_abnormal_sleep_pattern1.86985693
26MP0002102_abnormal_ear_morphology1.84924086
27MP0003787_abnormal_imprinting1.80430412
28MP0001440_abnormal_grooming_behavior1.73354653
29MP0004742_abnormal_vestibular_system1.71549881
30MP0001905_abnormal_dopamine_level1.69756011
31MP0002557_abnormal_social/conspecific_i1.66308227
32MP0010386_abnormal_urinary_bladder1.64273327
33MP0001984_abnormal_olfaction1.61392166
34MP0004142_abnormal_muscle_tone1.60794178
35MP0000778_abnormal_nervous_system1.60450760
36MP0002638_abnormal_pupillary_reflex1.54721727
37MP0008877_abnormal_DNA_methylation1.51623056
38MP0004924_abnormal_behavior1.45921740
39MP0005386_behavior/neurological_phenoty1.45921740
40MP0002184_abnormal_innervation1.43621770
41MP0006072_abnormal_retinal_apoptosis1.41572610
42MP0008872_abnormal_physiological_respon1.41516257
43MP0008569_lethality_at_weaning1.38820809
44MP0006292_abnormal_olfactory_placode1.38317561
45MP0003122_maternal_imprinting1.38306394
46MP0001485_abnormal_pinna_reflex1.37993738
47MP0005253_abnormal_eye_physiology1.35102732
48MP0004885_abnormal_endolymph1.32887706
49MP0004133_heterotaxia1.32739347
50MP0003195_calcinosis1.29623740
51MP0004215_abnormal_myocardial_fiber1.25353674
52MP0002882_abnormal_neuron_morphology1.24410737
53MP0000631_abnormal_neuroendocrine_gland1.24410682
54MP0004145_abnormal_muscle_electrophysio1.22883435
55MP0003879_abnormal_hair_cell1.22593686
56MP0001529_abnormal_vocalization1.21436165
57MP0003011_delayed_dark_adaptation1.16577597
58MP0000955_abnormal_spinal_cord1.13741379
59MP0003646_muscle_fatigue1.13702168
60MP0001188_hyperpigmentation1.11996637
61MP0003633_abnormal_nervous_system1.11101309
62MP0002066_abnormal_motor_capabilities/c1.07613703
63MP0002876_abnormal_thyroid_physiology1.07197969
64MP0002837_dystrophic_cardiac_calcinosis1.07046350
65MP0001986_abnormal_taste_sensitivity1.05967548
66MP0002752_abnormal_somatic_nervous1.02946375
67MP0005410_abnormal_fertilization1.02019642
68MP0005171_absent_coat_pigmentation1.01451652
69MP0004811_abnormal_neuron_physiology1.00634467
70MP0000230_abnormal_systemic_arterial0.99583568
71MP0005645_abnormal_hypothalamus_physiol0.99500418
72MP0003283_abnormal_digestive_organ0.97612671
73MP0002229_neurodegeneration0.97464241
74MP0001502_abnormal_circadian_rhythm0.95874196
75MP0004147_increased_porphyrin_level0.94842657
76MP0001963_abnormal_hearing_physiology0.94605157
77MP0003121_genomic_imprinting0.93262312
78MP0004130_abnormal_muscle_cell0.93119627
79MP0004085_abnormal_heartbeat0.89458794
80MP0003137_abnormal_impulse_conducting0.89338721
81MP0003136_yellow_coat_color0.85681471
82MP0002653_abnormal_ependyma_morphology0.85305172
83MP0002152_abnormal_brain_morphology0.85058738
84MP0002751_abnormal_autonomic_nervous0.84868797
85MP0003631_nervous_system_phenotype0.84710966
86MP0000026_abnormal_inner_ear0.83775684
87MP0002938_white_spotting0.82129276
88MP0005084_abnormal_gallbladder_morpholo0.81982928
89MP0002909_abnormal_adrenal_gland0.81250240
90MP0005195_abnormal_posterior_eye0.81014352
91MP0004043_abnormal_pH_regulation0.76236366
92MP0003119_abnormal_digestive_system0.74429973
93MP0005187_abnormal_penis_morphology0.73234389
94MP0002069_abnormal_eating/drinking_beha0.71836434
95MP0008775_abnormal_heart_ventricle0.69791790
96MP0003638_abnormal_response/metabolism_0.67800564
97MP0003698_abnormal_male_reproductive0.67238969
98MP0002234_abnormal_pharynx_morphology0.66923353
99MP0002160_abnormal_reproductive_system0.65229157
100MP0005620_abnormal_muscle_contractility0.61361012

Predicted human phenotypes

RankGene SetZ-score
1Febrile seizures (HP:0002373)5.37885466
2Focal motor seizures (HP:0011153)5.36431311
3Atonic seizures (HP:0010819)4.95875178
4Focal seizures (HP:0007359)4.68704121
5Progressive cerebellar ataxia (HP:0002073)4.58107322
6Dialeptic seizures (HP:0011146)3.94822777
7Epileptic encephalopathy (HP:0200134)3.75940302
8Myokymia (HP:0002411)3.72123795
9Gaze-evoked nystagmus (HP:0000640)3.71179543
10Absence seizures (HP:0002121)3.61990359
11Hyperventilation (HP:0002883)3.53692114
12Action tremor (HP:0002345)3.42666105
13Pancreatic fibrosis (HP:0100732)3.34830319
14Congenital stationary night blindness (HP:0007642)3.31250101
15Pancreatic cysts (HP:0001737)3.26206718
16Limb dystonia (HP:0002451)3.25689769
17Broad-based gait (HP:0002136)3.24507988
18Genetic anticipation (HP:0003743)3.22192867
19Nephronophthisis (HP:0000090)3.17519155
20Generalized tonic-clonic seizures (HP:0002069)3.11446071
21True hermaphroditism (HP:0010459)3.09858066
22Abnormality of midbrain morphology (HP:0002418)2.95435618
23Molar tooth sign on MRI (HP:0002419)2.95435618
24Hemiparesis (HP:0001269)2.93148626
25Inability to walk (HP:0002540)2.72049770
26Decreased central vision (HP:0007663)2.65860525
27Medial flaring of the eyebrow (HP:0010747)2.65599583
28Gait imbalance (HP:0002141)2.61926455
29Hypothermia (HP:0002045)2.60795282
30Abnormality of the renal medulla (HP:0100957)2.59535859
31Diplopia (HP:0000651)2.57679268
32Abnormality of binocular vision (HP:0011514)2.57679268
33Optic nerve hypoplasia (HP:0000609)2.51224352
34Abolished electroretinogram (ERG) (HP:0000550)2.49830453
35Epileptiform EEG discharges (HP:0011182)2.42375520
36Type II lissencephaly (HP:0007260)2.41981780
37Congenital sensorineural hearing impairment (HP:0008527)2.39501061
38Dysdiadochokinesis (HP:0002075)2.38461102
39Absent speech (HP:0001344)2.34449072
40Attenuation of retinal blood vessels (HP:0007843)2.33680837
41Aplasia/Hypoplasia of the tibia (HP:0005772)2.30583604
42Pendular nystagmus (HP:0012043)2.29816753
43Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.28380268
44Keratoconus (HP:0000563)2.27980390
45Increased corneal curvature (HP:0100692)2.27980390
46EEG with generalized epileptiform discharges (HP:0011198)2.26065486
47Polyphagia (HP:0002591)2.25449178
48Agitation (HP:0000713)2.24855155
49Congenital primary aphakia (HP:0007707)2.23260023
50Drooling (HP:0002307)2.22795232
51Decreased circulating renin level (HP:0003351)2.17548723
52Abnormal drinking behavior (HP:0030082)2.17006078
53Polydipsia (HP:0001959)2.17006078
54Chorioretinal atrophy (HP:0000533)2.10685282
55Genital tract atresia (HP:0001827)2.10317965
56Hypsarrhythmia (HP:0002521)2.09400908
57Status epilepticus (HP:0002133)2.06633628
58Visual hallucinations (HP:0002367)2.05212736
59Nephrogenic diabetes insipidus (HP:0009806)2.03866083
60Cystic liver disease (HP:0006706)2.02459584
61Progressive macrocephaly (HP:0004481)2.00497130
62Abnormal eating behavior (HP:0100738)2.00437726
63Protruding tongue (HP:0010808)1.99672990
64Abnormal rod and cone electroretinograms (HP:0008323)1.99101655
65Lissencephaly (HP:0001339)1.96713140
66Excessive salivation (HP:0003781)1.96465637
67Vaginal atresia (HP:0000148)1.96348271
68Sclerocornea (HP:0000647)1.95746035
69Prolonged QT interval (HP:0001657)1.95501655
70Aplasia/Hypoplasia of the tongue (HP:0010295)1.95297011
71Chronic hepatic failure (HP:0100626)1.95249600
72Acute necrotizing encephalopathy (HP:0006965)1.94167061
73Impaired smooth pursuit (HP:0007772)1.92609566
74Bony spicule pigmentary retinopathy (HP:0007737)1.92607778
75Abnormality of the renal cortex (HP:0011035)1.90792346
76Poor eye contact (HP:0000817)1.89128217
77Hemiplegia (HP:0002301)1.86812237
78Progressive inability to walk (HP:0002505)1.85887984
79Specific learning disability (HP:0001328)1.83497212
80Absent rod-and cone-mediated responses on ERG (HP:0007688)1.81647777
81Urinary bladder sphincter dysfunction (HP:0002839)1.80836395
82Short tibia (HP:0005736)1.80222847
833-Methylglutaconic aciduria (HP:0003535)1.79917719
84Thyroid-stimulating hormone excess (HP:0002925)1.79913422
85Impaired vibration sensation in the lower limbs (HP:0002166)1.79071403
86Morphological abnormality of the pyramidal tract (HP:0002062)1.78517340
87Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.78038747
88Abnormality of alanine metabolism (HP:0010916)1.78038747
89Hyperalaninemia (HP:0003348)1.78038747
90Methylmalonic acidemia (HP:0002912)1.76429822
91Amblyopia (HP:0000646)1.75005544
92Truncal ataxia (HP:0002078)1.74580167
93Poor coordination (HP:0002370)1.74547305
94Abnormality of the corticospinal tract (HP:0002492)1.73929112
95Abnormality of the labia minora (HP:0012880)1.73621724
96Degeneration of the lateral corticospinal tracts (HP:0002314)1.67982765
97Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.67982765
98Pachygyria (HP:0001302)1.67680812
99Furrowed tongue (HP:0000221)1.67077381
100Anencephaly (HP:0002323)1.65125911

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.27095790
2CASK3.73323409
3MARK13.71838831
4MAPK132.57920472
5MAP4K22.56432825
6NTRK32.51355398
7PNCK2.44762025
8ADRBK22.41492920
9BMPR1B2.34234181
10PINK12.30633675
11EPHA42.17800649
12MAP3K41.99656303
13NTRK21.97001142
14DAPK21.96112071
15WNK31.83465547
16GRK11.78730601
17PRKCG1.71475562
18TNIK1.63562365
19GRK51.56450195
20PLK21.53848195
21MAP3K121.40389064
22DYRK21.40114735
23MAP2K71.37158586
24CSNK1G21.36017701
25ZAK1.35537913
26MINK11.35107167
27PAK31.31260984
28OXSR11.26557788
29NUAK11.26001831
30TLK11.24479315
31INSRR1.23463420
32PRKCE1.20018604
33CAMK2A1.18401625
34TAOK31.17894551
35BCR1.07669730
36ACVR1B1.07173616
37TRIM281.05149425
38CSNK1G11.04738943
39MKNK21.04236040
40CSNK1G31.03439220
41STK391.02111659
42WNK40.99779575
43PHKG10.99713681
44PHKG20.99713681
45CDK190.99166132
46MAP3K90.95435477
47PAK60.91964972
48ADRBK10.91788353
49PKN10.91316764
50CAMK10.89598785
51SGK20.87877711
52STK38L0.87876469
53CAMK2B0.82044143
54CDK50.81486214
55CAMKK20.79079671
56SGK4940.77091842
57SGK2230.77091842
58PTK2B0.75284828
59MAP2K40.75148997
60ERBB30.74899714
61DYRK1A0.74757348
62SIK20.74647987
63UHMK10.73752598
64MAPKAPK50.73044813
65OBSCN0.65591579
66PRKG10.63359436
67CSNK1A1L0.62842902
68CAMK1G0.62711695
69PRKACA0.61309637
70PRKCZ0.57537978
71SGK10.54602639
72DAPK10.52251144
73MYLK0.50310200
74CSNK1D0.49489564
75MAP2K60.49285355
76MAPKAPK30.48380364
77CSNK1A10.48219639
78CAMK2D0.47714344
79PRKCA0.47491033
80STK30.45157742
81STK110.43540537
82CAMK2G0.40382507
83PRKCQ0.39276192
84TEC0.37582026
85VRK10.37107902
86TIE10.36509854
87CDK30.36131896
88PRKCH0.35850821
89PRKCB0.35753916
90PRKACG0.35587504
91STK160.34653748
92ERBB20.34336114
93RPS6KA30.31732938
94CAMK40.31607592
95PRKACB0.31546778
96WNK10.29824323
97MKNK10.29601403
98CDK140.28968207
99PRKAA10.28589258
100PLK30.26654207

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.46182510
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.82312881
3Morphine addiction_Homo sapiens_hsa050322.81331322
4GABAergic synapse_Homo sapiens_hsa047272.75267712
5Glutamatergic synapse_Homo sapiens_hsa047242.73103839
6Circadian entrainment_Homo sapiens_hsa047132.71806211
7Taste transduction_Homo sapiens_hsa047422.40796942
8Phototransduction_Homo sapiens_hsa047442.39696173
9Nitrogen metabolism_Homo sapiens_hsa009102.16504881
10Long-term depression_Homo sapiens_hsa047302.03058373
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.02648841
12Amphetamine addiction_Homo sapiens_hsa050312.01190296
13Synaptic vesicle cycle_Homo sapiens_hsa047211.97593283
14Serotonergic synapse_Homo sapiens_hsa047261.97444968
15Insulin secretion_Homo sapiens_hsa049111.96836016
16Dopaminergic synapse_Homo sapiens_hsa047281.95063736
17Olfactory transduction_Homo sapiens_hsa047401.94087987
18Cocaine addiction_Homo sapiens_hsa050301.85279263
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.72096208
20Cardiac muscle contraction_Homo sapiens_hsa042601.69726124
21Oxidative phosphorylation_Homo sapiens_hsa001901.56950833
22Calcium signaling pathway_Homo sapiens_hsa040201.53324624
23Salivary secretion_Homo sapiens_hsa049701.52406562
24Butanoate metabolism_Homo sapiens_hsa006501.52088134
25Cholinergic synapse_Homo sapiens_hsa047251.50883844
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.41007793
27Renin secretion_Homo sapiens_hsa049241.39524845
28Parkinsons disease_Homo sapiens_hsa050121.36776480
29Gastric acid secretion_Homo sapiens_hsa049711.36767657
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36152697
31Long-term potentiation_Homo sapiens_hsa047201.29781191
32Linoleic acid metabolism_Homo sapiens_hsa005911.28942639
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.26133287
34Oxytocin signaling pathway_Homo sapiens_hsa049211.25446562
35Collecting duct acid secretion_Homo sapiens_hsa049661.21535057
36Dorso-ventral axis formation_Homo sapiens_hsa043201.15262120
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.13969140
38Alzheimers disease_Homo sapiens_hsa050101.11369788
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.10937827
40Gap junction_Homo sapiens_hsa045401.09631442
41Vascular smooth muscle contraction_Homo sapiens_hsa042701.03550454
42cAMP signaling pathway_Homo sapiens_hsa040240.97468872
43Circadian rhythm_Homo sapiens_hsa047100.96918001
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96432155
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.95673960
46Protein export_Homo sapiens_hsa030600.94198146
47Pancreatic secretion_Homo sapiens_hsa049720.91748239
48Ether lipid metabolism_Homo sapiens_hsa005650.91742457
49Regulation of autophagy_Homo sapiens_hsa041400.88889512
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88629579
51Tryptophan metabolism_Homo sapiens_hsa003800.85759856
52Type II diabetes mellitus_Homo sapiens_hsa049300.82053626
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81336108
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81202567
55Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.80147126
56Huntingtons disease_Homo sapiens_hsa050160.77285064
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75320026
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73330343
59Axon guidance_Homo sapiens_hsa043600.72504661
60Selenocompound metabolism_Homo sapiens_hsa004500.68060778
61Ovarian steroidogenesis_Homo sapiens_hsa049130.65688083
62ABC transporters_Homo sapiens_hsa020100.65274890
63Glycerolipid metabolism_Homo sapiens_hsa005610.63880475
64Dilated cardiomyopathy_Homo sapiens_hsa054140.63561507
65Ras signaling pathway_Homo sapiens_hsa040140.63368689
66Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.62712496
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57697054
68Platelet activation_Homo sapiens_hsa046110.57194131
69Caffeine metabolism_Homo sapiens_hsa002320.54974021
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53615917
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53160085
72Fatty acid biosynthesis_Homo sapiens_hsa000610.51628772
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50920768
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50209082
75Alcoholism_Homo sapiens_hsa050340.48581555
76MAPK signaling pathway_Homo sapiens_hsa040100.48388399
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47995628
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47812938
79Hedgehog signaling pathway_Homo sapiens_hsa043400.47637313
80Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47154992
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.46651102
82Estrogen signaling pathway_Homo sapiens_hsa049150.46233532
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46218997
84Thyroid hormone synthesis_Homo sapiens_hsa049180.45849330
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.44447868
86Arachidonic acid metabolism_Homo sapiens_hsa005900.43613838
87Basal transcription factors_Homo sapiens_hsa030220.42649420
88Chemical carcinogenesis_Homo sapiens_hsa052040.41364371
89Oocyte meiosis_Homo sapiens_hsa041140.40823866
90beta-Alanine metabolism_Homo sapiens_hsa004100.40210382
91Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.39857022
92Rap1 signaling pathway_Homo sapiens_hsa040150.39313320
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39242881
94Retinol metabolism_Homo sapiens_hsa008300.39161159
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39049760
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38527980
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.38119606
98Melanogenesis_Homo sapiens_hsa049160.37568531
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35583410
100Propanoate metabolism_Homo sapiens_hsa006400.34150172

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »