ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	intraciliary transport (GO:0042073)	3.55820306
2	presynaptic membrane assembly (GO:0097105)	3.52785718
3	synapsis (GO:0007129)	3.43259901
4	cilium or flagellum-dependent cell motility (GO:0001539)	3.26536873
5	resolution of meiotic recombination intermediates (GO:0000712)	3.22363031
6	presynaptic membrane organization (GO:0097090)	3.17991458
7	DNA double-strand break processing (GO:0000729)	3.13236449
8	pyrimidine nucleobase catabolic process (GO:0006208)	3.11139514
9	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.09544552
10	positive regulation of mitochondrial fission (GO:0090141)	2.97981527
11	purine nucleobase biosynthetic process (GO:0009113)	2.86954422
12	epithelial cilium movement (GO:0003351)	2.81281044
13	L-serine metabolic process (GO:0006563)	2.79613910
14	protein-cofactor linkage (GO:0018065)	2.76583368
15	nonmotile primary cilium assembly (GO:0035058)	2.75622819
16	proteasome assembly (GO:0043248)	2.74872241
17	reciprocal DNA recombination (GO:0035825)	2.70756385
18	reciprocal meiotic recombination (GO:0007131)	2.70756385
19	chromatin remodeling at centromere (GO:0031055)	2.69851116
20	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.67597922
21	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.67597922
22	CENP-A containing nucleosome assembly (GO:0034080)	2.61863959
23	establishment of integrated proviral latency (GO:0075713)	2.60396509
24	axonemal dynein complex assembly (GO:0070286)	2.59158176
25	cholesterol biosynthetic process (GO:0006695)	2.58006074
26	DNA replication checkpoint (GO:0000076)	2.57987501
27	nuclear pore organization (GO:0006999)	2.57849685
28	DNA integration (GO:0015074)	2.56814896
29	cilium morphogenesis (GO:0060271)	2.56089264
30	cilium assembly (GO:0042384)	2.54268156
31	centriole replication (GO:0007099)	2.51474540
32	cilium organization (GO:0044782)	2.51432051
33	nucleobase biosynthetic process (GO:0046112)	2.51338456
34	negative regulation of DNA recombination (GO:0045910)	2.50802372
35	neuron cell-cell adhesion (GO:0007158)	2.49828129
36	postsynaptic membrane organization (GO:0001941)	2.47712872
37	male meiosis I (GO:0007141)	2.47634465
38	ribonucleoprotein complex disassembly (GO:0032988)	2.47327651
39	piRNA metabolic process (GO:0034587)	2.47308237
40	nuclear pore complex assembly (GO:0051292)	2.46645231
41	cilium movement (GO:0003341)	2.46105937
42	nucleobase catabolic process (GO:0046113)	2.44085222
43	regulation of cilium movement (GO:0003352)	2.43920809
44	histone H2A acetylation (GO:0043968)	2.43189159
45	isoprenoid biosynthetic process (GO:0008299)	2.38878093
46	IMP biosynthetic process (GO:0006188)	2.37584566
47	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.37289103
48	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.37289103
49	organelle disassembly (GO:1903008)	2.36936053
50	DNA methylation involved in gamete generation (GO:0043046)	2.35950944
51	chromosome organization involved in meiosis (GO:0070192)	2.35775009
52	retinal ganglion cell axon guidance (GO:0031290)	2.35696490
53	sterol biosynthetic process (GO:0016126)	2.34398386
54	regulation of meiosis I (GO:0060631)	2.34290490
55	histone exchange (GO:0043486)	2.34008783
56	maturation of 5.8S rRNA (GO:0000460)	2.33339241
57	establishment of mitochondrion localization (GO:0051654)	2.30006202
58	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.29243627
59	intra-S DNA damage checkpoint (GO:0031573)	2.28240231
60	photoreceptor cell maintenance (GO:0045494)	2.28078638
61	positive regulation of RNA splicing (GO:0033120)	2.25915282
62	protein localization to synapse (GO:0035418)	2.25796872
63	regulation of centriole replication (GO:0046599)	2.24851264
64	protein polyglutamylation (GO:0018095)	2.22935206
65	behavioral response to nicotine (GO:0035095)	2.22051524
66	tRNA aminoacylation for protein translation (GO:0006418)	2.21296446
67	V(D)J recombination (GO:0033151)	2.21194929
68	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.21129977
69	protein localization to kinetochore (GO:0034501)	2.20693586
70	gamma-aminobutyric acid transport (GO:0015812)	2.19318921
71	amino acid activation (GO:0043038)	2.19241760
72	tRNA aminoacylation (GO:0043039)	2.19241760
73	gene silencing by RNA (GO:0031047)	2.18738321
74	mitotic metaphase plate congression (GO:0007080)	2.18491397
75	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.18108203
76	cullin deneddylation (GO:0010388)	2.18091200
77	male meiosis (GO:0007140)	2.17869728
78	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.17503797
79	DNA damage response, detection of DNA damage (GO:0042769)	2.16626056
80	protein localization to cilium (GO:0061512)	2.15211956
81	transmission of nerve impulse (GO:0019226)	2.15101584
82	regulation of helicase activity (GO:0051095)	2.14552042
83	negative regulation of membrane potential (GO:0045837)	2.13490415
84	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.13285406
85	regulation of mitotic spindle checkpoint (GO:1903504)	2.13285406
86	replication fork processing (GO:0031297)	2.11759144
87	vocalization behavior (GO:0071625)	2.11128882
88	sister chromatid segregation (GO:0000819)	2.10846078
89	DNA replication-independent nucleosome assembly (GO:0006336)	2.10273475
90	DNA replication-independent nucleosome organization (GO:0034724)	2.10273475
91	behavioral response to cocaine (GO:0048148)	2.10238364
92	microtubule polymerization or depolymerization (GO:0031109)	2.10196006
93	mitochondrion transport along microtubule (GO:0047497)	2.09995931
94	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.09995931
95	meiotic cell cycle process (GO:1903046)	2.09883941
96	non-recombinational repair (GO:0000726)	2.09856586
97	double-strand break repair via nonhomologous end joining (GO:0006303)	2.09856586
98	regulation of microtubule-based movement (GO:0060632)	2.09277126
99	axoneme assembly (GO:0035082)	2.08941726
100	regulation of translation, ncRNA-mediated (GO:0045974)	2.08751656

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RBPJ_22232070_ChIP-Seq_NCS_Mouse	4.76877584
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.07804937
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.05716297
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.02870904
5	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.60933832
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.59126903
7	FUS_26573619_Chip-Seq_HEK293_Human	2.48878302
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.48037223
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.31808410
10	EWS_26573619_Chip-Seq_HEK293_Human	2.28389162
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.22718191
12	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.14612520
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.13734073
14	VDR_22108803_ChIP-Seq_LS180_Human	2.13674384
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.11893482
16	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.07499147
17	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.03985081
18	GBX2_23144817_ChIP-Seq_PC3_Human	2.02016484
19	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.95404063
20	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.91661002
21	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.89837859
22	ELK1_19687146_ChIP-ChIP_HELA_Human	1.88730420
23	MYC_18940864_ChIP-ChIP_HL60_Human	1.77658570
24	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.77035432
25	P300_19829295_ChIP-Seq_ESCs_Human	1.75932052
26	IRF1_19129219_ChIP-ChIP_H3396_Human	1.72836956
27	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.71350905
28	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.70449869
29	RNF2_27304074_Chip-Seq_NSC_Mouse	1.67370870
30	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.66866562
31	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.65590716
32	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.65058132
33	E2F7_22180533_ChIP-Seq_HELA_Human	1.64812014
34	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.58450044
35	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.53876311
36	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.52230045
37	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.43623217
38	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.42631524
39	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.40772995
40	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.40603625
41	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.40273300
42	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.39598376
43	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.37756212
44	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.36514092
45	VDR_23849224_ChIP-Seq_CD4+_Human	1.35614725
46	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.35045461
47	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.34878512
48	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.34732854
49	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.34042195
50	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.29671999
51	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.29369846
52	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.29248567
53	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.29237005
54	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.26651762
55	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.24647215
56	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.24437904
57	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.24376865
58	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.24136831
59	CBP_20019798_ChIP-Seq_JUKART_Human	1.23222092
60	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.23222092
61	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.22283416
62	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.21687019
63	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.21687019
64	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.21687019
65	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.20760349
66	SMAD4_21799915_ChIP-Seq_A2780_Human	1.20515618
67	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.17970049
68	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.17285794
69	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.16938350
70	STAT3_23295773_ChIP-Seq_U87_Human	1.14969435
71	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.14730558
72	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.13323125
73	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.12191926
74	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.11632779
75	RUNX2_22187159_ChIP-Seq_PCA_Human	1.08582466
76	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.08247279
77	ER_23166858_ChIP-Seq_MCF-7_Human	1.08086599
78	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.06440186
79	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.06122661
80	JUN_21703547_ChIP-Seq_K562_Human	1.05821332
81	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.05127510
82	TTF2_22483619_ChIP-Seq_HELA_Human	1.04053553
83	SOX9_26525672_Chip-Seq_HEART_Mouse	1.03183342
84	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.02849521
85	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.02188421
86	FOXM1_23109430_ChIP-Seq_U2OS_Human	0.98816347
87	AR_25329375_ChIP-Seq_VCAP_Human	0.98801470
88	FOXP3_21729870_ChIP-Seq_TREG_Human	0.97084843
89	TCF4_23295773_ChIP-Seq_U87_Human	0.95678036
90	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.94667568
91	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.94148120
92	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.93761838
93	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.93090420
94	TP53_22573176_ChIP-Seq_HFKS_Human	0.92422819
95	GABP_19822575_ChIP-Seq_HepG2_Human	0.92195726
96	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.92045183
97	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.91289718
98	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.90216626
99	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.90216626
100	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.89557352

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	2.86566722
2	MP0008877_abnormal_DNA_methylation	2.76528846
3	MP0008058_abnormal_DNA_repair	2.73332716
4	MP0000566_synostosis	2.58597737
5	MP0003136_yellow_coat_color	2.39926407
6	MP0010094_abnormal_chromosome_stability	2.32498281
7	MP0001529_abnormal_vocalization	2.19795564
8	MP0006292_abnormal_olfactory_placode	2.18550235
9	MP0004133_heterotaxia	2.12164010
10	MP0003122_maternal_imprinting	1.98787326
11	MP0003693_abnormal_embryo_hatching	1.95155779
12	MP0000778_abnormal_nervous_system	1.94322831
13	MP0001293_anophthalmia	1.85336653
14	MP0002102_abnormal_ear_morphology	1.84541788
15	MP0006276_abnormal_autonomic_nervous	1.82737312
16	MP0003718_maternal_effect	1.77833400
17	MP0003937_abnormal_limbs/digits/tail_de	1.71325786
18	MP0002938_white_spotting	1.67257983
19	MP0003890_abnormal_embryonic-extraembry	1.58223815
20	MP0004147_increased_porphyrin_level	1.57416861
21	MP0003121_genomic_imprinting	1.54351384
22	MP0006072_abnormal_retinal_apoptosis	1.53954285
23	MP0008932_abnormal_embryonic_tissue	1.43592801
24	MP0000631_abnormal_neuroendocrine_gland	1.43513977
25	MP0005253_abnormal_eye_physiology	1.39261511
26	MP0002653_abnormal_ependyma_morphology	1.38797713
27	MP0003567_abnormal_fetal_cardiomyocyte	1.37655429
28	MP0008995_early_reproductive_senescence	1.37157423
29	MP0008789_abnormal_olfactory_epithelium	1.37062998
30	MP0000647_abnormal_sebaceous_gland	1.37052898
31	MP0002233_abnormal_nose_morphology	1.34657679
32	MP0001984_abnormal_olfaction	1.34305697
33	MP0002210_abnormal_sex_determination	1.33966542
34	MP0004859_abnormal_synaptic_plasticity	1.33734087
35	MP0009046_muscle_twitch	1.33341076
36	MP0003698_abnormal_male_reproductive	1.30167891
37	MP0005551_abnormal_eye_electrophysiolog	1.29313242
38	MP0000383_abnormal_hair_follicle	1.28222664
39	MP0004742_abnormal_vestibular_system	1.28207149
40	MP0001188_hyperpigmentation	1.27257816
41	MP0004957_abnormal_blastocyst_morpholog	1.26408224
42	MP0001929_abnormal_gametogenesis	1.26025699
43	MP0002736_abnormal_nociception_after	1.23365667
44	MP0003077_abnormal_cell_cycle	1.23039657
45	MP0003861_abnormal_nervous_system	1.20342205
46	MP0003635_abnormal_synaptic_transmissio	1.17515543
47	MP0002184_abnormal_innervation	1.16646566
48	MP0000049_abnormal_middle_ear	1.15869154
49	MP0001486_abnormal_startle_reflex	1.14292696
50	MP0003119_abnormal_digestive_system	1.14074601
51	MP0009745_abnormal_behavioral_response	1.13273501
52	MP0002751_abnormal_autonomic_nervous	1.12894548
53	MP0008007_abnormal_cellular_replicative	1.12499765
54	MP0002572_abnormal_emotion/affect_behav	1.11320341
55	MP0002272_abnormal_nervous_system	1.10958645
56	MP0002067_abnormal_sensory_capabilities	1.10255343
57	MP0000653_abnormal_sex_gland	1.09255754
58	MP0001145_abnormal_male_reproductive	1.08224628
59	MP0001286_abnormal_eye_development	1.07205396
60	MP0010030_abnormal_orbit_morphology	1.06758633
61	MP0005394_taste/olfaction_phenotype	1.06360958
62	MP0005499_abnormal_olfactory_system	1.06360958
63	MP0000955_abnormal_spinal_cord	1.06202563
64	MP0002752_abnormal_somatic_nervous	1.06062815
65	MP0005187_abnormal_penis_morphology	1.05903371
66	MP0005391_vision/eye_phenotype	1.04660972
67	MP0002234_abnormal_pharynx_morphology	1.04276357
68	MP0002084_abnormal_developmental_patter	1.02195404
69	MP0003787_abnormal_imprinting	1.01967611
70	MP0001968_abnormal_touch/_nociception	1.01169850
71	MP0002063_abnormal_learning/memory/cond	1.00890031
72	MP0004270_analgesia	0.98455358
73	MP0003111_abnormal_nucleus_morphology	0.98236694
74	MP0002152_abnormal_brain_morphology	0.95527780
75	MP0000427_abnormal_hair_cycle	0.95506020
76	MP0002249_abnormal_larynx_morphology	0.95414551
77	MP0002557_abnormal_social/conspecific_i	0.93428167
78	MP0002882_abnormal_neuron_morphology	0.91735939
79	MP0001299_abnormal_eye_distance/	0.90964009
80	MP0000372_irregular_coat_pigmentation	0.90598210
81	MP0002734_abnormal_mechanical_nocicepti	0.88974840
82	MP0000026_abnormal_inner_ear	0.87939792
83	MP0002132_abnormal_respiratory_system	0.87712198
84	MP0005171_absent_coat_pigmentation	0.87327015
85	MP0001485_abnormal_pinna_reflex	0.87242170
86	MP0003755_abnormal_palate_morphology	0.86815388
87	MP0002085_abnormal_embryonic_tissue	0.86643253
88	MP0003786_premature_aging	0.85953179
89	MP0008057_abnormal_DNA_replication	0.84814299
90	MP0005195_abnormal_posterior_eye	0.84441498
91	MP0002160_abnormal_reproductive_system	0.84140549
92	MP0002638_abnormal_pupillary_reflex	0.83243216
93	MP0003938_abnormal_ear_development	0.83033960
94	MP0004811_abnormal_neuron_physiology	0.82195246
95	MP0002095_abnormal_skin_pigmentation	0.81840867
96	MP0004142_abnormal_muscle_tone	0.80546161
97	MP0002161_abnormal_fertility/fecundity	0.80392541
98	MP0009697_abnormal_copulation	0.80336904
99	MP0009703_decreased_birth_body	0.79735188
100	MP0004924_abnormal_behavior	0.79627610

Predicted human phenotypes

Rank	Gene Set	Z-score
1	True hermaphroditism (HP:0010459)	3.59649321
2	Pancreatic fibrosis (HP:0100732)	3.50551089
3	Gait imbalance (HP:0002141)	3.43629672
4	Molar tooth sign on MRI (HP:0002419)	3.41801836
5	Abnormality of midbrain morphology (HP:0002418)	3.41801836
6	Chronic hepatic failure (HP:0100626)	3.25128422
7	Cortical dysplasia (HP:0002539)	3.20186580
8	Congenital primary aphakia (HP:0007707)	3.17465416
9	Medial flaring of the eyebrow (HP:0010747)	3.08915641
10	Abnormality of the labia minora (HP:0012880)	3.06594187
11	Pancreatic cysts (HP:0001737)	2.98488213
12	Nephronophthisis (HP:0000090)	2.93931466
13	Nephrogenic diabetes insipidus (HP:0009806)	2.77318182
14	Supernumerary spleens (HP:0009799)	2.74537127
15	Genital tract atresia (HP:0001827)	2.74023723
16	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.65244379
17	Absent/shortened dynein arms (HP:0200106)	2.65244379
18	Vaginal atresia (HP:0000148)	2.64321115
19	Hyperglycinemia (HP:0002154)	2.64121047
20	Abnormal respiratory epithelium morphology (HP:0012253)	2.55916069
21	Abnormal respiratory motile cilium morphology (HP:0005938)	2.55916069
22	Poor coordination (HP:0002370)	2.54225551
23	Postaxial foot polydactyly (HP:0001830)	2.50521958
24	Abnormal ciliary motility (HP:0012262)	2.46786001
25	Abnormality of the renal medulla (HP:0100957)	2.37864280
26	Bifid tongue (HP:0010297)	2.35850557
27	Abnormal respiratory motile cilium physiology (HP:0012261)	2.34437936
28	Hyperglycinuria (HP:0003108)	2.30492502
29	Preaxial hand polydactyly (HP:0001177)	2.30055500
30	B lymphocytopenia (HP:0010976)	2.27019663
31	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.24021123
32	Retinal dysplasia (HP:0007973)	2.23119814
33	Broad foot (HP:0001769)	2.22834877
34	Occipital encephalocele (HP:0002085)	2.21059474
35	Hypoplasia of the thymus (HP:0000778)	2.19323900
36	Sclerocornea (HP:0000647)	2.18553930
37	Drooling (HP:0002307)	2.17106092
38	Postaxial hand polydactyly (HP:0001162)	2.15964712
39	Colon cancer (HP:0003003)	2.15355543
40	Abnormality of serine family amino acid metabolism (HP:0010894)	2.11500842
41	Abnormality of glycine metabolism (HP:0010895)	2.11500842
42	Anencephaly (HP:0002323)	2.11146298
43	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.05178829
44	Specific learning disability (HP:0001328)	2.01151204
45	Abnormality of B cell number (HP:0010975)	1.99997047
46	Median cleft lip (HP:0000161)	1.98394178
47	Polyphagia (HP:0002591)	1.97388973
48	Decreased central vision (HP:0007663)	1.97388368
49	Short tibia (HP:0005736)	1.97231008
50	Abnormal biliary tract physiology (HP:0012439)	1.95317021
51	Bile duct proliferation (HP:0001408)	1.95317021
52	Abnormal lung lobation (HP:0002101)	1.94529157
53	Tubulointerstitial nephritis (HP:0001970)	1.93958496
54	Type II lissencephaly (HP:0007260)	1.92122808
55	Volvulus (HP:0002580)	1.91327103
56	Oculomotor apraxia (HP:0000657)	1.90640313
57	Excessive salivation (HP:0003781)	1.87437805
58	Methylmalonic acidemia (HP:0002912)	1.86802187
59	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.86618987
60	Hyperventilation (HP:0002883)	1.86204469
61	Cystic liver disease (HP:0006706)	1.85896127
62	Erythroderma (HP:0001019)	1.83062510
63	Amyotrophic lateral sclerosis (HP:0007354)	1.81640728
64	Septo-optic dysplasia (HP:0100842)	1.80758394
65	Abnormality of macular pigmentation (HP:0008002)	1.80689241
66	Abnormality of serum amino acid levels (HP:0003112)	1.80466112
67	Severe combined immunodeficiency (HP:0004430)	1.79929918
68	Optic nerve hypoplasia (HP:0000609)	1.79586522
69	Anophthalmia (HP:0000528)	1.79434651
70	Optic nerve coloboma (HP:0000588)	1.77846859
71	Progressive cerebellar ataxia (HP:0002073)	1.77524845
72	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.77504119
73	Dandy-Walker malformation (HP:0001305)	1.75865646
74	Oligodactyly (hands) (HP:0001180)	1.73238460
75	Prominent nasal bridge (HP:0000426)	1.72507140
76	Multicystic kidney dysplasia (HP:0000003)	1.72298635
77	Aganglionic megacolon (HP:0002251)	1.72007945
78	Abnormality of alanine metabolism (HP:0010916)	1.70395929
79	Hyperalaninemia (HP:0003348)	1.70395929
80	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.70395929
81	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.70319665
82	Astigmatism (HP:0000483)	1.70030206
83	Thyroiditis (HP:0100646)	1.67742623
84	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.67700934
85	Birth length less than 3rd percentile (HP:0003561)	1.66875198
86	Neuroendocrine neoplasm (HP:0100634)	1.66371315
87	Methylmalonic aciduria (HP:0012120)	1.66177866
88	Micropenis (HP:0000054)	1.64591282
89	Gonadotropin excess (HP:0000837)	1.64155816
90	Lissencephaly (HP:0001339)	1.63992020
91	Broad-based gait (HP:0002136)	1.62943833
92	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.62794866
93	Cutaneous finger syndactyly (HP:0010554)	1.62659886
94	Meckel diverticulum (HP:0002245)	1.62611737
95	Narrow forehead (HP:0000341)	1.62147136
96	Partial agenesis of the corpus callosum (HP:0001338)	1.61985631
97	Male pseudohermaphroditism (HP:0000037)	1.61455561
98	Pendular nystagmus (HP:0012043)	1.60765171
99	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.60717956
100	Sloping forehead (HP:0000340)	1.60097603

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CASK	3.78901650
2	WNK3	3.43525686
3	MAP3K4	2.71319992
4	MARK1	2.64568340
5	CDK19	2.41378868
6	PNCK	2.40804993
7	MAP2K7	2.23611146
8	BCR	2.16516454
9	SRPK1	2.15212226
10	TSSK6	2.12492196
11	DYRK2	2.11668309
12	EIF2AK3	1.86968300
13	TNIK	1.85600315
14	EPHA4	1.82279436
15	TRIM28	1.78297759
16	MKNK2	1.73333898
17	NEK1	1.71943132
18	PLK3	1.68479473
19	NUAK1	1.67827271
20	TTK	1.67721067
21	FRK	1.61080678
22	CDC7	1.58908304
23	MKNK1	1.58220502
24	PBK	1.55411534
25	MAPK13	1.53248312
26	ZAK	1.52750661
27	STK16	1.48030541
28	BMPR1B	1.47413697
29	RPS6KA4	1.37375932
30	PLK4	1.35908081
31	BUB1	1.33326015
32	PINK1	1.32190228
33	NTRK2	1.28578379
34	DYRK3	1.26704302
35	VRK1	1.26275795
36	BRSK2	1.25496977
37	WEE1	1.24657944
38	PLK2	1.20088975
39	VRK2	1.17641982
40	PLK1	1.17400649
41	BCKDK	1.13132046
42	ERBB3	1.12127067
43	MAP4K2	1.09863947
44	ADRBK2	1.08220313
45	CSNK1G2	1.05592696
46	NEK2	1.02720615
47	CSNK1A1L	1.01694879
48	MET	0.97888541
49	CHEK2	0.97265337
50	TAF1	0.96256451
51	ATR	0.96051604
52	CSNK1G3	0.96000427
53	CSNK1G1	0.95662713
54	STK38L	0.93229365
55	MAPK15	0.89734383
56	MAP2K4	0.87445458
57	DYRK1A	0.83405098
58	NTRK3	0.81788123
59	EIF2AK1	0.74188061
60	MAP3K10	0.72396137
61	LATS1	0.72322805
62	ATM	0.71402764
63	PKN1	0.70825685
64	MINK1	0.68788728
65	MAP3K12	0.68336431
66	OXSR1	0.68315296
67	PRKCE	0.63707216
68	INSRR	0.63036392
69	EIF2AK2	0.62808100
70	PRKCG	0.61969956
71	PHKG2	0.61582632
72	PHKG1	0.61582632
73	BRSK1	0.59424177
74	KSR1	0.59025256
75	PAK3	0.57608139
76	CDK3	0.56638582
77	FLT3	0.54716267
78	GRK1	0.54430955
79	CSNK1E	0.51430619
80	BRD4	0.49187420
81	TGFBR1	0.47756317
82	CAMK1G	0.45794371
83	CAMK2A	0.45594353
84	PRKD3	0.45591120
85	DYRK1B	0.43379292
86	PRKDC	0.41888559
87	UHMK1	0.41452626
88	CDK1	0.40410554
89	CHEK1	0.40026086
90	FGFR2	0.39302405
91	AURKB	0.38605225
92	AURKA	0.38569551
93	WNK4	0.38501588
94	NTRK1	0.37359264
95	CDK2	0.36197857
96	RPS6KB1	0.35815410
97	NME1	0.34418861
98	SIK2	0.31572856
99	FGFR1	0.31041966
100	STK3	0.29451731

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.08084174
2	Non-homologous end-joining_Homo sapiens_hsa03450	2.97324313
3	Propanoate metabolism_Homo sapiens_hsa00640	2.74566550
4	Steroid biosynthesis_Homo sapiens_hsa00100	2.58153211
5	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.51920291
6	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.44432423
7	Basal transcription factors_Homo sapiens_hsa03022	2.36675588
8	Mismatch repair_Homo sapiens_hsa03430	2.31453985
9	Nicotine addiction_Homo sapiens_hsa05033	2.10626043
10	Fanconi anemia pathway_Homo sapiens_hsa03460	2.05281562
11	Homologous recombination_Homo sapiens_hsa03440	2.03897916
12	RNA transport_Homo sapiens_hsa03013	2.03681931
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.02461899
14	Protein export_Homo sapiens_hsa03060	2.02281694
15	Butanoate metabolism_Homo sapiens_hsa00650	1.96937394
16	Nucleotide excision repair_Homo sapiens_hsa03420	1.91234876
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.85947486
18	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.85808643
19	RNA degradation_Homo sapiens_hsa03018	1.71782438
20	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.68798655
21	Proteasome_Homo sapiens_hsa03050	1.67830429
22	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.60493415
23	DNA replication_Homo sapiens_hsa03030	1.58841499
24	Base excision repair_Homo sapiens_hsa03410	1.54211439
25	RNA polymerase_Homo sapiens_hsa03020	1.52600239
26	Spliceosome_Homo sapiens_hsa03040	1.51829807
27	Phototransduction_Homo sapiens_hsa04744	1.40415523
28	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.37965435
29	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.33975909
30	Cell cycle_Homo sapiens_hsa04110	1.32231967
31	One carbon pool by folate_Homo sapiens_hsa00670	1.32136322
32	mRNA surveillance pathway_Homo sapiens_hsa03015	1.29272635
33	Parkinsons disease_Homo sapiens_hsa05012	1.28519015
34	Selenocompound metabolism_Homo sapiens_hsa00450	1.26161056
35	Oxidative phosphorylation_Homo sapiens_hsa00190	1.24500182
36	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.23214211
37	Pyruvate metabolism_Homo sapiens_hsa00620	1.17187253
38	Huntingtons disease_Homo sapiens_hsa05016	1.16634167
39	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.16005696
40	Fatty acid elongation_Homo sapiens_hsa00062	1.12831405
41	beta-Alanine metabolism_Homo sapiens_hsa00410	1.11942944
42	Oocyte meiosis_Homo sapiens_hsa04114	1.09138411
43	Taste transduction_Homo sapiens_hsa04742	1.04121979
44	Fatty acid metabolism_Homo sapiens_hsa01212	1.01806327
45	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.99672557
46	Olfactory transduction_Homo sapiens_hsa04740	0.96845357
47	Purine metabolism_Homo sapiens_hsa00230	0.96241462
48	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.92586781
49	Basal cell carcinoma_Homo sapiens_hsa05217	0.91050005
50	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.88803357
51	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.85694522
52	GABAergic synapse_Homo sapiens_hsa04727	0.85650318
53	Hippo signaling pathway_Homo sapiens_hsa04390	0.85427072
54	Pyrimidine metabolism_Homo sapiens_hsa00240	0.84180387
55	Carbon metabolism_Homo sapiens_hsa01200	0.83690295
56	Peroxisome_Homo sapiens_hsa04146	0.77009979
57	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.76603331
58	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.76205674
59	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.73022126
60	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.72744794
61	Lysine degradation_Homo sapiens_hsa00310	0.70350911
62	Axon guidance_Homo sapiens_hsa04360	0.69946618
63	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.68234048
64	Arginine and proline metabolism_Homo sapiens_hsa00330	0.68031376
65	Morphine addiction_Homo sapiens_hsa05032	0.67220630
66	Alzheimers disease_Homo sapiens_hsa05010	0.67001513
67	Regulation of autophagy_Homo sapiens_hsa04140	0.65616291
68	Metabolic pathways_Homo sapiens_hsa01100	0.65459297
69	Glutathione metabolism_Homo sapiens_hsa00480	0.62582052
70	p53 signaling pathway_Homo sapiens_hsa04115	0.61383688
71	Cardiac muscle contraction_Homo sapiens_hsa04260	0.60208629
72	Wnt signaling pathway_Homo sapiens_hsa04310	0.60022104
73	Fatty acid degradation_Homo sapiens_hsa00071	0.59227397
74	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.58082001
75	Glutamatergic synapse_Homo sapiens_hsa04724	0.57917954
76	Ribosome_Homo sapiens_hsa03010	0.57241765
77	Ether lipid metabolism_Homo sapiens_hsa00565	0.56377821
78	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.55633741
79	Circadian rhythm_Homo sapiens_hsa04710	0.54899783
80	Dopaminergic synapse_Homo sapiens_hsa04728	0.54292907
81	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.52480254
82	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.52233879
83	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.50605928
84	Linoleic acid metabolism_Homo sapiens_hsa00591	0.49097965
85	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.48305295
86	Folate biosynthesis_Homo sapiens_hsa00790	0.45191929
87	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.44624452
88	Nitrogen metabolism_Homo sapiens_hsa00910	0.43933006
89	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.43498128
90	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.42717021
91	Caffeine metabolism_Homo sapiens_hsa00232	0.42465760
92	Circadian entrainment_Homo sapiens_hsa04713	0.42268298
93	Cocaine addiction_Homo sapiens_hsa05030	0.41872854
94	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.41743721
95	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.39940164
96	Amphetamine addiction_Homo sapiens_hsa05031	0.37033694
97	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.36914443
98	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.36702196
99	Tryptophan metabolism_Homo sapiens_hsa00380	0.36282180
100	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.32243195

ZNF391

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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