ZNF394

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a zinc finger protein that inhibits the transcription of mitogen-activated protein kinase signaling pathways. The encoded protein may be involved in cardiac function. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.95476690
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.92238571
3antigen processing and presentation of endogenous antigen (GO:0019883)5.65542265
4positive regulation of gamma-delta T cell activation (GO:0046645)5.36020323
5positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.73001209
6positive regulation of antigen processing and presentation (GO:0002579)4.60350849
7positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.38521750
8regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.24552175
9negative regulation of cell killing (GO:0031342)4.20694631
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.20694631
11regulation of gamma-delta T cell activation (GO:0046643)4.09871576
12antigen processing and presentation via MHC class Ib (GO:0002475)4.08659863
13positive regulation of B cell differentiation (GO:0045579)4.08010981
14regulation of B cell receptor signaling pathway (GO:0050855)4.06406031
15immunoglobulin mediated immune response (GO:0016064)4.01523742
16negative T cell selection (GO:0043383)3.92245456
17T cell migration (GO:0072678)3.91283977
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.88964918
19negative thymic T cell selection (GO:0045060)3.86798567
20regulation of antigen processing and presentation (GO:0002577)3.80780327
21regulation of gamma-delta T cell differentiation (GO:0045586)3.79629035
22neutrophil activation involved in immune response (GO:0002283)3.68495752
23modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.65910595
24positive regulation by organism of defense response of other organism involved in symbiotic interact3.65910595
25modulation by symbiont of host immune response (GO:0052553)3.65910595
26positive regulation by symbiont of host defense response (GO:0052509)3.65910595
27modulation by symbiont of host defense response (GO:0052031)3.65910595
28modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.65910595
29lactate metabolic process (GO:0006089)3.60440473
30positive T cell selection (GO:0043368)3.58306113
31positive regulation of granulocyte differentiation (GO:0030854)3.58244163
32regulation of B cell differentiation (GO:0045577)3.56450786
33activated T cell proliferation (GO:0050798)3.55221591
34regulation of dendritic cell antigen processing and presentation (GO:0002604)3.50268371
35leukocyte aggregation (GO:0070486)3.48883904
36cellular extravasation (GO:0045123)3.46861778
37positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.40785041
38negative regulation of interleukin-12 production (GO:0032695)3.38626780
39B cell mediated immunity (GO:0019724)3.34750570
40regulation of alpha-beta T cell proliferation (GO:0046640)3.32091478
41interferon-gamma production (GO:0032609)3.31211277
42cellular response to type I interferon (GO:0071357)3.29108704
43type I interferon signaling pathway (GO:0060337)3.29108704
44T cell selection (GO:0045058)3.29024251
45detection of other organism (GO:0098543)3.28547856
46B cell receptor signaling pathway (GO:0050853)3.28495422
47response to peptidoglycan (GO:0032494)3.28409098
48detection of bacterium (GO:0016045)3.26431695
49response to type I interferon (GO:0034340)3.25923160
50positive thymic T cell selection (GO:0045059)3.23694223
51respiratory burst (GO:0045730)3.23556880
52tolerance induction (GO:0002507)3.18281357
53interferon-gamma secretion (GO:0072643)3.18007735
54neutrophil activation (GO:0042119)3.16211733
55negative regulation of T cell mediated immunity (GO:0002710)3.10516307
56mast cell activation (GO:0045576)3.10513024
57response to interferon-beta (GO:0035456)3.09761890
58negative regulation of bone resorption (GO:0045779)2.95925392
59positive regulation of alpha-beta T cell proliferation (GO:0046641)2.93620327
60granulocyte activation (GO:0036230)2.92850688
61regulation of granulocyte differentiation (GO:0030852)2.92849280
62macrophage activation involved in immune response (GO:0002281)2.92100791
63negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.92069078
64interferon-gamma-mediated signaling pathway (GO:0060333)2.85953582
65antigen receptor-mediated signaling pathway (GO:0050851)2.84232056
66regulation of interferon-beta biosynthetic process (GO:0045357)2.81330311
67microglial cell activation (GO:0001774)2.80596371
68response to protozoan (GO:0001562)2.80497493
69defense response to protozoan (GO:0042832)2.79905419
70myeloid cell activation involved in immune response (GO:0002275)2.76560482
71regulation of regulatory T cell differentiation (GO:0045589)2.74698499
72regulation of Golgi to plasma membrane protein transport (GO:0042996)2.74455050
73cellular response to interleukin-15 (GO:0071350)2.74418519
74regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.74274048
75negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.73453401
76negative regulation of lymphocyte mediated immunity (GO:0002707)2.73356820
77neutrophil mediated immunity (GO:0002446)2.73139964
78regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.71832998
79thymic T cell selection (GO:0045061)2.71698016
80positive regulation of interleukin-2 production (GO:0032743)2.70468053
81response to interleukin-15 (GO:0070672)2.70082922
82natural killer cell differentiation (GO:0001779)2.69031715
83response to host immune response (GO:0052572)2.68054163
84response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.68054163
85serotonin metabolic process (GO:0042428)2.67039324
86regulation of type I interferon-mediated signaling pathway (GO:0060338)2.66996424
87negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.66964550
88alpha-beta T cell activation (GO:0046631)2.65231141
89negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.64209798
90negative regulation of T-helper cell differentiation (GO:0045623)2.64209798
91negative regulation of interleukin-6 production (GO:0032715)2.63831775
92alpha-beta T cell differentiation (GO:0046632)2.62340704
93negative regulation of innate immune response (GO:0045824)2.60960247
94regulation of T-helper 1 cell differentiation (GO:0045625)2.60779880
95macrophage activation (GO:0042116)2.59138985
96regulation of T cell mediated cytotoxicity (GO:0001914)2.58094569
97regulation of interleukin-6 biosynthetic process (GO:0045408)2.56876467
98T cell receptor signaling pathway (GO:0050852)2.56602487
99regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.56438622
100regulation of natural killer cell mediated immunity (GO:0002715)2.56438622

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.23770124
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.08864030
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.09701665
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.84801958
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.79474739
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.56291637
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.44177547
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.09892229
9MYB_26560356_Chip-Seq_TH2_Human2.94659633
10RUNX_20019798_ChIP-Seq_JUKART_Human2.79269718
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.69231383
12SCL_19346495_ChIP-Seq_HPC-7_Human2.66612865
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.57705463
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.52112435
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.49994520
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.48719429
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.45983262
18MYB_26560356_Chip-Seq_TH1_Human2.42888252
19IRF8_27001747_Chip-Seq_BMDM_Mouse2.39904734
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.39206540
21SPI1_23547873_ChIP-Seq_NB4_Human2.39028802
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.31247390
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.21392626
24MAF_26560356_Chip-Seq_TH1_Human2.08681963
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.03312058
26GATA3_26560356_Chip-Seq_TH2_Human2.00501171
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.99647648
28GATA3_27048872_Chip-Seq_THYMUS_Human1.97799766
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.96065437
30VDR_24763502_ChIP-Seq_THP-1_Human1.93947905
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.91867956
32VDR_21846776_ChIP-Seq_THP-1_Human1.90810532
33* VDR_23849224_ChIP-Seq_CD4+_Human1.90372185
34NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.89336509
35CIITA_25753668_ChIP-Seq_RAJI_Human1.89195757
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.87713353
37UTX_26944678_Chip-Seq_JUKART_Human1.85841050
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.79166468
39MAF_26560356_Chip-Seq_TH2_Human1.78295323
40LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.75634512
41VDR_24787735_ChIP-Seq_THP-1_Human1.64591266
42SPI1_23127762_ChIP-Seq_K562_Human1.59885622
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54120870
44RUNX1_22412390_ChIP-Seq_EML_Mouse1.51715371
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.50658234
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.50070676
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.45961088
48ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42108629
49FOXP3_21729870_ChIP-Seq_TREG_Human1.40880818
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.40557757
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.40365837
52MYC_22102868_ChIP-Seq_BL_Human1.37905173
53SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37792354
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.36762126
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.29957416
56PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21675365
57* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20731401
58GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.19564067
59* GABP_17652178_ChIP-ChIP_JURKAT_Human1.18005289
60RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16556598
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14417212
62SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.13742652
63NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11759836
64EGR1_23403033_ChIP-Seq_LIVER_Mouse1.11037077
65PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10800303
66* EST1_17652178_ChIP-ChIP_JURKAT_Human1.07264535
67RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.07055305
68* ETS1_20019798_ChIP-Seq_JURKAT_Human1.04833008
69GATA2_22383799_ChIP-Seq_G1ME_Mouse1.04374465
70STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04203406
71JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.02801958
72Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.00892286
73KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00682722
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.99434652
75ZNF274_21170338_ChIP-Seq_K562_Hela0.99331445
76STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98513680
77CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95318153
78CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94856823
79CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94315661
80HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.93670390
81SMRT_27268052_Chip-Seq_Bcells_Human0.92489207
82ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91841099
83PU_27001747_Chip-Seq_BMDM_Mouse0.91264703
84PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90598229
85BCL6_27268052_Chip-Seq_Bcells_Human0.89055242
86FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.88096569
87CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87387629
88RAC3_21632823_ChIP-Seq_H3396_Human0.87096895
89GATA1_19941827_ChIP-Seq_MEL_Mouse0.85722348
90GATA1_19941826_ChIP-Seq_K562_Human0.85084856
91PU.1_20513432_ChIP-Seq_Bcells_Mouse0.83213461
92GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82451793
93P300_27268052_Chip-Seq_Bcells_Human0.81439260
94TFEB_21752829_ChIP-Seq_HELA_Human0.78550393
95VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.78153901
96CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.78057468
97PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77191528
98TCF7_22412390_ChIP-Seq_EML_Mouse0.76094357
99GATA1_22383799_ChIP-Seq_G1ME_Mouse0.75531211
100GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.75448352

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.38081428
2MP0005671_abnormal_response_to3.38478171
3MP0003436_decreased_susceptibility_to3.34129885
4MP0001800_abnormal_humoral_immune3.06990062
5MP0003763_abnormal_thymus_physiology2.91157528
6MP0003724_increased_susceptibility_to2.88570589
7MP0005000_abnormal_immune_tolerance2.77160876
8MP0001790_abnormal_immune_system2.76469033
9MP0005387_immune_system_phenotype2.76469033
10MP0000685_abnormal_immune_system2.65970070
11MP0002723_abnormal_immune_serum2.65489875
12MP0002452_abnormal_antigen_presenting2.58787620
13MP0002420_abnormal_adaptive_immunity2.55514851
14MP0001819_abnormal_immune_cell2.51214097
15MP0002419_abnormal_innate_immunity2.50279270
16MP0005025_abnormal_response_to2.46308865
17MP0009785_altered_susceptibility_to2.44696961
18MP0002148_abnormal_hypersensitivity_rea2.40776599
19MP0003303_peritoneal_inflammation2.35828649
20MP0009333_abnormal_splenocyte_physiolog2.17388500
21MP0003787_abnormal_imprinting2.14757641
22MP0002398_abnormal_bone_marrow2.10844053
23MP0000716_abnormal_immune_system2.00088088
24MP0000689_abnormal_spleen_morphology1.92157282
25MP0005464_abnormal_platelet_physiology1.85591172
26MP0006082_CNS_inflammation1.84604808
27MP0001873_stomach_inflammation1.80915840
28MP0002166_altered_tumor_susceptibility1.75969519
29MP0002405_respiratory_system_inflammati1.72350196
30MP0002722_abnormal_immune_system1.70545215
31MP0010155_abnormal_intestine_physiology1.69421296
32MP0000703_abnormal_thymus_morphology1.68095971
33MP0001545_abnormal_hematopoietic_system1.62258030
34MP0005397_hematopoietic_system_phenotyp1.62258030
35MP0001845_abnormal_inflammatory_respons1.61777398
36MP0002429_abnormal_blood_cell1.61635835
37MP0009764_decreased_sensitivity_to1.61055728
38MP0005075_abnormal_melanosome_morpholog1.56944521
39MP0002396_abnormal_hematopoietic_system1.50411949
40MP0001533_abnormal_skeleton_physiology1.47336908
41MP0003646_muscle_fatigue1.45232198
42MP0005310_abnormal_salivary_gland1.44803616
43MP0004947_skin_inflammation1.43496833
44MP0004381_abnormal_hair_follicle1.41523760
45MP0002006_tumorigenesis1.39083701
46MP0002138_abnormal_hepatobiliary_system1.37910953
47MP0004808_abnormal_hematopoietic_stem1.36740875
48MP0003866_abnormal_defecation1.35276266
49MP0009278_abnormal_bone_marrow1.31666805
50MP0008469_abnormal_protein_level1.30349094
51MP0002254_reproductive_system_inflammat1.29149344
52MP0008877_abnormal_DNA_methylation1.25430627
53MP0001853_heart_inflammation1.24373477
54MP0005647_abnormal_sex_gland1.20246856
55MP0008995_early_reproductive_senescence1.18313922
56MP0000015_abnormal_ear_pigmentation1.16669889
57MP0001919_abnormal_reproductive_system1.15095183
58MP0003172_abnormal_lysosome_physiology1.12322398
59MP0001851_eye_inflammation1.10488341
60MP0003656_abnormal_erythrocyte_physiolo1.09991194
61MP0002132_abnormal_respiratory_system1.07662998
62MP0001501_abnormal_sleep_pattern1.06957128
63MP0000465_gastrointestinal_hemorrhage1.05189067
64MP0002933_joint_inflammation1.04677653
65MP0003828_pulmonary_edema1.03202461
66MP0001764_abnormal_homeostasis0.99586727
67MP0002277_abnormal_respiratory_mucosa0.99066415
68MP0009840_abnormal_foam_cell0.98395052
69MP0002009_preneoplasia0.97355694
70MP0008260_abnormal_autophagy0.96854526
71MP0001986_abnormal_taste_sensitivity0.92175344
72MP0008004_abnormal_stomach_pH0.90869423
73MP0003786_premature_aging0.89042911
74MP0003300_gastrointestinal_ulcer0.88383229
75MP0002998_abnormal_bone_remodeling0.87468579
76MP0002693_abnormal_pancreas_physiology0.86242305
77MP0005451_abnormal_body_composition0.84594639
78MP0001663_abnormal_digestive_system0.83881471
79MP0008057_abnormal_DNA_replication0.83675974
80MP0005389_reproductive_system_phenotype0.83191151
81MP0008961_abnormal_basal_metabolism0.81484957
82MP0002019_abnormal_tumor_incidence0.80906505
83MP0005410_abnormal_fertilization0.78499177
84MP0008058_abnormal_DNA_repair0.74330336
85MP0009763_increased_sensitivity_to0.73783645
86MP0005360_urolithiasis0.71440850
87MP0000858_altered_metastatic_potential0.70191319
88MP0000470_abnormal_stomach_morphology0.68657257
89MP0000371_diluted_coat_color0.62402734
90MP0003806_abnormal_nucleotide_metabolis0.61523494
91MP0002332_abnormal_exercise_endurance0.60811859
92MP0000372_irregular_coat_pigmentation0.60430603
93MP0003252_abnormal_bile_duct0.59000458
94MP0009765_abnormal_xenobiotic_induced0.58083119
95MP0000490_abnormal_crypts_of0.57948553
96MP0005535_abnormal_body_temperature0.57016467
97MP0004883_abnormal_blood_vessel0.55348087
98MP0002136_abnormal_kidney_physiology0.54821468
99MP0003191_abnormal_cellular_cholesterol0.54612698
100MP0003195_calcinosis0.53895689

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)5.39248554
2Elevated erythrocyte sedimentation rate (HP:0003565)5.32008747
3Recurrent fungal infections (HP:0002841)4.22416971
4Chronic otitis media (HP:0000389)4.21446806
5Recurrent bacterial skin infections (HP:0005406)4.18407613
6Abnormal delayed hypersensitivity skin test (HP:0002963)4.08841401
7Chronic mucocutaneous candidiasis (HP:0002728)4.08388270
8Recurrent cutaneous fungal infections (HP:0011370)4.08388270
9Recurrent abscess formation (HP:0002722)3.90702135
10Panhypogammaglobulinemia (HP:0003139)3.82077861
11IgG deficiency (HP:0004315)3.80213317
12Encephalitis (HP:0002383)3.66835437
13Myositis (HP:0100614)3.62857328
14Recurrent bronchitis (HP:0002837)3.47925937
15Eczematoid dermatitis (HP:0000976)3.41888071
16Abnormality of macrophages (HP:0004311)3.38389269
17Recurrent viral infections (HP:0004429)3.36130340
18Retrobulbar optic neuritis (HP:0100654)3.30241514
19Optic neuritis (HP:0100653)3.30241514
20Recurrent skin infections (HP:0001581)3.28300454
21Meningitis (HP:0001287)3.25320725
22Increased IgM level (HP:0003496)3.22684826
23T lymphocytopenia (HP:0005403)3.18898766
24Abnormality of T cells (HP:0002843)3.16337473
25Hypochromic microcytic anemia (HP:0004840)3.16308476
26Abnormality of T cell number (HP:0011839)3.16224686
27Autoimmune hemolytic anemia (HP:0001890)3.14205093
28Increased IgE level (HP:0003212)3.12145014
29Pustule (HP:0200039)3.12117729
30Mediastinal lymphadenopathy (HP:0100721)3.10995918
31Chronic sinusitis (HP:0011109)3.04916822
32Agammaglobulinemia (HP:0004432)3.02289310
33Orchitis (HP:0100796)3.00460416
34Abnormality of T cell physiology (HP:0011840)2.97332036
35Increased neuronal autofluorescent lipopigment (HP:0002074)2.90835789
36Colitis (HP:0002583)2.87730932
37Severe combined immunodeficiency (HP:0004430)2.79260165
38Vasculitis (HP:0002633)2.79089049
39Inflammation of the large intestine (HP:0002037)2.77308347
40Abnormality of B cell number (HP:0010975)2.74233247
41Leukocytosis (HP:0001974)2.73725956
42Pulmonary infiltrates (HP:0002113)2.66592597
43Increased cerebral lipofuscin (HP:0011813)2.64260753
44Hypochromic anemia (HP:0001931)2.63737580
45Gastrointestinal inflammation (HP:0004386)2.57863393
46Microcytic anemia (HP:0001935)2.55810696
47IgM deficiency (HP:0002850)2.54754866
48Granulocytopenia (HP:0001913)2.54090170
49Hypergammaglobulinemia (HP:0010702)2.51362071
50Autoimmune thrombocytopenia (HP:0001973)2.49626102
51Lymphopenia (HP:0001888)2.46529705
52Prolonged bleeding time (HP:0003010)2.45008037
53Keratoconjunctivitis (HP:0001096)2.44261177
54Eosinophilia (HP:0001880)2.43416925
55Obstructive lung disease (HP:0006536)2.41730157
56Chronic obstructive pulmonary disease (HP:0006510)2.41730157
57Abnormality of the prostate (HP:0008775)2.41259775
58B lymphocytopenia (HP:0010976)2.40862193
59Abnormality of eosinophils (HP:0001879)2.38455033
60Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.38435501
61Hemoptysis (HP:0002105)2.30058788
62Nasal polyposis (HP:0100582)2.28611423
63Stomach cancer (HP:0012126)2.25389358
64Prostate neoplasm (HP:0100787)2.25354966
65Hematochezia (HP:0002573)2.24179753
66Premature loss of primary teeth (HP:0006323)2.23605896
67Combined immunodeficiency (HP:0005387)2.22857077
68Recurrent gram-negative bacterial infections (HP:0005420)2.21390179
69Abnormality of cells of the lymphoid lineage (HP:0012140)2.21233148
70Albinism (HP:0001022)2.19003806
71Keratoconjunctivitis sicca (HP:0001097)2.17092248
72Chronic diarrhea (HP:0002028)2.16059075
73Chest pain (HP:0100749)2.15388775
74Urticaria (HP:0001025)2.14807413
75Thyroiditis (HP:0100646)2.12198662
76Neutropenia (HP:0001875)2.09086583
77Gastrointestinal infarctions (HP:0005244)2.08477472
78Abnormality of the heme biosynthetic pathway (HP:0010472)2.08055316
79Osteomyelitis (HP:0002754)2.05653991
80Vacuolated lymphocytes (HP:0001922)2.03268335
81Clumsiness (HP:0002312)2.02309258
82Petechiae (HP:0000967)2.00994364
83Bronchitis (HP:0012387)2.00226656
84Recurrent sinusitis (HP:0011108)1.99518267
85Alveolar cell carcinoma (HP:0006519)1.94066925
86Epistaxis (HP:0000421)1.93841679
87IgA deficiency (HP:0002720)1.92349932
88Tetany (HP:0001281)1.90029357
89Progressive inability to walk (HP:0002505)1.89344802
90Viral hepatitis (HP:0006562)1.86131063
91Verrucae (HP:0200043)1.85404449
92Papilloma (HP:0012740)1.85404449
93Acute hepatic failure (HP:0006554)1.84250626
94Gangrene (HP:0100758)1.83114850
95Abnormality of the fingertips (HP:0001211)1.82741630
96Anorexia (HP:0002039)1.78715881
97Joint swelling (HP:0001386)1.77501435
98Prominent nose (HP:0000448)1.77115582
99Abnormality of the nasal mucosa (HP:0000433)1.76476015
100Keratitis (HP:0000491)1.76361562

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B5.10331667
2MAP4K13.87273967
3TXK3.21536824
4TAOK33.17556023
5TEC2.87792595
6RIPK42.61422505
7MST42.37536546
8TYK22.35491396
9IKBKE2.28728875
10MARK32.28409296
11BTK2.06285341
12ITK2.06048790
13TLK12.01047938
14IKBKB1.92748390
15SYK1.88468908
16BLK1.82925225
17JAK31.82006731
18TNK21.81408332
19MAP2K31.81234066
20IRAK41.76032529
21KIT1.75136222
22FES1.68234725
23GRK61.65718798
24HCK1.50582466
25ZAP701.48969839
26JAK11.48019167
27STK101.46866005
28TESK21.46156088
29IRAK11.45907271
30MAP3K141.38340543
31TBK11.37123256
32FRK1.35768333
33BMPR21.32567706
34PIM11.32196193
35NUAK11.30343618
36CSK1.27248169
37LCK1.27191685
38LYN1.25316800
39GRK71.24834239
40HIPK21.23002178
41CSF1R1.22350407
42FLT31.15850355
43MAP3K111.10442700
44MAP3K31.08374415
45ZAK1.05177050
46PRPF4B0.97798610
47PRKCQ0.95865833
48PIK3CG0.91737730
49ADRBK20.87165938
50CHUK0.86120552
51SIK30.78234281
52JAK20.73633626
53CLK10.73494851
54MATK0.70795164
55NLK0.68570085
56BCKDK0.68175171
57TGFBR20.66166008
58TAOK20.65131498
59MAP2K20.61839005
60MAPK130.61232384
61CAMKK20.59691485
62SCYL20.57208332
63LRRK20.56366247
64IRAK20.54885380
65RPS6KA50.54449391
66MAP3K10.53547245
67PRKCI0.52159493
68PDK10.49817477
69TAOK10.49105226
70MAP2K60.48407831
71ABL10.46059133
72PDK20.45165386
73PIM20.43433045
74ERN10.42026556
75PTK2B0.41223208
76CDK40.41209428
77MAPK110.38484406
78BRSK20.34925836
79AKT30.33033791
80MAPK70.31142700
81VRK10.30409597
82MAP3K50.29609942
83GRK50.29298688
84MAPK120.29004875
85PAK30.28623104
86FGR0.28074216
87TRPM70.27611237
88GRK10.25789781
89KDR0.25757654
90RPS6KA60.25699909
91MAPKAPK20.25662987
92MAPKAPK30.25053549
93MAPK30.22749088
94BRD40.22710871
95CCNB10.22324113
96ERBB30.20835962
97STK110.20662662
98PRKD20.20545717
99ADRBK10.20254697
100RAF10.19438236

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.28867991
2Graft-versus-host disease_Homo sapiens_hsa053323.31168162
3Allograft rejection_Homo sapiens_hsa053303.28393426
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.12652361
5Autoimmune thyroid disease_Homo sapiens_hsa053203.05895631
6Asthma_Homo sapiens_hsa053102.65574471
7Type I diabetes mellitus_Homo sapiens_hsa049402.43936630
8Antigen processing and presentation_Homo sapiens_hsa046122.38362661
9Leishmaniasis_Homo sapiens_hsa051402.38227008
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.31767850
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.27834824
12NOD-like receptor signaling pathway_Homo sapiens_hsa046212.18973835
13Osteoclast differentiation_Homo sapiens_hsa043802.12630897
14Staphylococcus aureus infection_Homo sapiens_hsa051502.07241855
15NF-kappa B signaling pathway_Homo sapiens_hsa040642.03687528
16Hematopoietic cell lineage_Homo sapiens_hsa046401.95167968
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.93148181
18B cell receptor signaling pathway_Homo sapiens_hsa046621.91841299
19T cell receptor signaling pathway_Homo sapiens_hsa046601.90003359
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.87060642
21SNARE interactions in vesicular transport_Homo sapiens_hsa041301.86188340
22Herpes simplex infection_Homo sapiens_hsa051681.83562479
23Measles_Homo sapiens_hsa051621.79651288
24Tuberculosis_Homo sapiens_hsa051521.71864468
25Rheumatoid arthritis_Homo sapiens_hsa053231.65199972
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.51784935
27Viral myocarditis_Homo sapiens_hsa054161.50116258
28Influenza A_Homo sapiens_hsa051641.46622141
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.40489809
30Legionellosis_Homo sapiens_hsa051341.39718196
31Toxoplasmosis_Homo sapiens_hsa051451.23819954
32TNF signaling pathway_Homo sapiens_hsa046681.23019841
33Acute myeloid leukemia_Homo sapiens_hsa052211.16095063
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.12597896
35Epstein-Barr virus infection_Homo sapiens_hsa051691.10159615
36Systemic lupus erythematosus_Homo sapiens_hsa053221.09394976
37Homologous recombination_Homo sapiens_hsa034401.05522769
38Malaria_Homo sapiens_hsa051441.05011422
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.98324869
40Hepatitis B_Homo sapiens_hsa051610.94691277
41Chemokine signaling pathway_Homo sapiens_hsa040620.92493945
42Regulation of autophagy_Homo sapiens_hsa041400.91528765
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.88297184
44Phagosome_Homo sapiens_hsa041450.85111764
45Shigellosis_Homo sapiens_hsa051310.84912513
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84439637
47Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82135928
48RNA polymerase_Homo sapiens_hsa030200.78719180
49Platelet activation_Homo sapiens_hsa046110.77182803
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75906940
51Pertussis_Homo sapiens_hsa051330.74447350
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72877454
53Hepatitis C_Homo sapiens_hsa051600.72491270
54African trypanosomiasis_Homo sapiens_hsa051430.72423232
55Apoptosis_Homo sapiens_hsa042100.71319058
56Viral carcinogenesis_Homo sapiens_hsa052030.70513082
57RNA degradation_Homo sapiens_hsa030180.69293135
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68419724
59Lysosome_Homo sapiens_hsa041420.64931324
60Fanconi anemia pathway_Homo sapiens_hsa034600.64879321
61Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.64577030
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61802737
63Glycerophospholipid metabolism_Homo sapiens_hsa005640.60830025
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60805544
65Other glycan degradation_Homo sapiens_hsa005110.59492023
66Basal transcription factors_Homo sapiens_hsa030220.56780050
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56691704
68Collecting duct acid secretion_Homo sapiens_hsa049660.55623755
69HTLV-I infection_Homo sapiens_hsa051660.55395675
70Proteasome_Homo sapiens_hsa030500.52321794
71Dorso-ventral axis formation_Homo sapiens_hsa043200.49764652
72Olfactory transduction_Homo sapiens_hsa047400.46797743
73ABC transporters_Homo sapiens_hsa020100.45796632
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44906368
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44498027
76Non-small cell lung cancer_Homo sapiens_hsa052230.42745243
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42063932
78Tryptophan metabolism_Homo sapiens_hsa003800.39466061
79Base excision repair_Homo sapiens_hsa034100.38261870
80Selenocompound metabolism_Homo sapiens_hsa004500.37285940
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36788072
82p53 signaling pathway_Homo sapiens_hsa041150.36602424
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.35217383
84FoxO signaling pathway_Homo sapiens_hsa040680.34370326
85Prolactin signaling pathway_Homo sapiens_hsa049170.33731846
86Linoleic acid metabolism_Homo sapiens_hsa005910.33376968
87VEGF signaling pathway_Homo sapiens_hsa043700.32045890
88Non-homologous end-joining_Homo sapiens_hsa034500.31528504
89Nitrogen metabolism_Homo sapiens_hsa009100.28211840
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.27837271
91Ribosome_Homo sapiens_hsa030100.27629131
92Nucleotide excision repair_Homo sapiens_hsa034200.26480588
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.23730538
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.23595786
95Inositol phosphate metabolism_Homo sapiens_hsa005620.22096801
96MAPK signaling pathway_Homo sapiens_hsa040100.21750450
97Fatty acid elongation_Homo sapiens_hsa000620.21680640
98Glycerolipid metabolism_Homo sapiens_hsa005610.20842033
99Spliceosome_Homo sapiens_hsa030400.18713789
100Mismatch repair_Homo sapiens_hsa034300.18079234

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