ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.96670526
2	L-fucose catabolic process (GO:0042355)	4.71326411
3	fucose catabolic process (GO:0019317)	4.71326411
4	L-fucose metabolic process (GO:0042354)	4.71326411
5	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.40479035
6	epithelial cilium movement (GO:0003351)	4.03626343
7	response to pheromone (GO:0019236)	3.91563560
8	cilium movement (GO:0003341)	3.77491764
9	axoneme assembly (GO:0035082)	3.76842221
10	cilium or flagellum-dependent cell motility (GO:0001539)	3.71368148
11	regulation of cilium movement (GO:0003352)	3.57246122
12	cellular ketone body metabolic process (GO:0046950)	3.52757060
13	DNA deamination (GO:0045006)	3.48722573
14	platelet dense granule organization (GO:0060155)	3.31337024
15	detection of light stimulus involved in visual perception (GO:0050908)	3.24422398
16	detection of light stimulus involved in sensory perception (GO:0050962)	3.24422398
17	gamma-aminobutyric acid transport (GO:0015812)	3.22356111
18	ketone body metabolic process (GO:1902224)	3.21903818
19	nonmotile primary cilium assembly (GO:0035058)	3.20930197
20	water-soluble vitamin biosynthetic process (GO:0042364)	3.18901361
21	axonemal dynein complex assembly (GO:0070286)	3.15074604
22	indolalkylamine metabolic process (GO:0006586)	3.14566634
23	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.09965359
24	NADH dehydrogenase complex assembly (GO:0010257)	3.09965359
25	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.09965359
26	tryptophan catabolic process (GO:0006569)	3.08849362
27	indole-containing compound catabolic process (GO:0042436)	3.08849362
28	indolalkylamine catabolic process (GO:0046218)	3.08849362
29	protein complex biogenesis (GO:0070271)	3.06635796
30	protein polyglutamylation (GO:0018095)	3.05538938
31	pyrimidine nucleobase catabolic process (GO:0006208)	3.04925149
32	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.04515227
33	cilium organization (GO:0044782)	3.04198143
34	exogenous drug catabolic process (GO:0042738)	3.01268633
35	protein localization to cilium (GO:0061512)	3.00775535
36	cilium assembly (GO:0042384)	2.94366585
37	protein-cofactor linkage (GO:0018065)	2.93031030
38	kynurenine metabolic process (GO:0070189)	2.91602501
39	neural tube formation (GO:0001841)	2.90102866
40	piRNA metabolic process (GO:0034587)	2.89354379
41	neuronal action potential (GO:0019228)	2.87796654
42	preassembly of GPI anchor in ER membrane (GO:0016254)	2.86560269
43	cilium morphogenesis (GO:0060271)	2.84283881
44	cornea development in camera-type eye (GO:0061303)	2.84184873
45	drug catabolic process (GO:0042737)	2.82544661
46	behavioral response to ethanol (GO:0048149)	2.81090494
47	negative regulation of telomere maintenance (GO:0032205)	2.79256340
48	negative regulation of mast cell activation (GO:0033004)	2.78150227
49	regulation of microtubule-based movement (GO:0060632)	2.77906768
50	mitochondrial respiratory chain complex assembly (GO:0033108)	2.76304985
51	intraciliary transport (GO:0042073)	2.74165506
52	nucleobase catabolic process (GO:0046113)	2.74040974
53	photoreceptor cell maintenance (GO:0045494)	2.72484420
54	kidney morphogenesis (GO:0060993)	2.72464227
55	respiratory chain complex IV assembly (GO:0008535)	2.69577289
56	sulfation (GO:0051923)	2.69524868
57	synaptic transmission, cholinergic (GO:0007271)	2.67274706
58	glycerophospholipid catabolic process (GO:0046475)	2.65687154
59	positive regulation of defense response to virus by host (GO:0002230)	2.61833457
60	regulation of action potential (GO:0098900)	2.60155465
61	nephron tubule morphogenesis (GO:0072078)	2.60028404
62	nephron epithelium morphogenesis (GO:0072088)	2.60028404
63	tryptophan metabolic process (GO:0006568)	2.58971787
64	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.54847007
65	reciprocal DNA recombination (GO:0035825)	2.54077317
66	reciprocal meiotic recombination (GO:0007131)	2.54077317
67	multicellular organism reproduction (GO:0032504)	2.54053183
68	regulation of memory T cell differentiation (GO:0043380)	2.53027866
69	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.52523324
70	DNA methylation involved in gamete generation (GO:0043046)	2.51439913
71	transmission of nerve impulse (GO:0019226)	2.51304876
72	S-adenosylmethionine metabolic process (GO:0046500)	2.50357157
73	regulation of neurotransmitter uptake (GO:0051580)	2.49283947
74	cytochrome complex assembly (GO:0017004)	2.49023377
75	retinal cone cell development (GO:0046549)	2.48974990
76	fucosylation (GO:0036065)	2.48092075
77	indole-containing compound metabolic process (GO:0042430)	2.47241478
78	rhodopsin mediated signaling pathway (GO:0016056)	2.47156641
79	primary amino compound metabolic process (GO:1901160)	2.46328288
80	positive regulation of fatty acid transport (GO:2000193)	2.45524879
81	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.44933363
82	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.43220175
83	negative regulation of T cell differentiation in thymus (GO:0033085)	2.43188879
84	reflex (GO:0060004)	2.43022887
85	positive regulation of meiosis (GO:0045836)	2.41969518
86	dendritic spine morphogenesis (GO:0060997)	2.41900691
87	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.41619257
88	cAMP catabolic process (GO:0006198)	2.41128918
89	spinal cord motor neuron differentiation (GO:0021522)	2.40691162
90	neurotransmitter metabolic process (GO:0042133)	2.40599118
91	male meiosis I (GO:0007141)	2.40141299
92	alanine transport (GO:0032328)	2.39685179
93	thyroid hormone metabolic process (GO:0042403)	2.39205422
94	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.38221892
95	serotonin metabolic process (GO:0042428)	2.37967542
96	proline transport (GO:0015824)	2.37390020
97	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.36006558
98	rRNA catabolic process (GO:0016075)	2.35001584
99	inositol phosphate catabolic process (GO:0071545)	2.33490120
100	photoreceptor cell development (GO:0042461)	2.32594373

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.08943228
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.75626805
3	VDR_22108803_ChIP-Seq_LS180_Human	3.37455932
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.78835886
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.54327902
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.32869027
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.29983206
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.28825535
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.25218462
10	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.19229669
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.12176261
12	FUS_26573619_Chip-Seq_HEK293_Human	2.09599017
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.08518301
14	EWS_26573619_Chip-Seq_HEK293_Human	2.03905211
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.01859549
16	* P300_19829295_ChIP-Seq_ESCs_Human	1.91948600
17	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.91653420
18	ER_23166858_ChIP-Seq_MCF-7_Human	1.89706419
19	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.87631951
20	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.75694448
21	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.74765165
22	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.65477984
23	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.62203936
24	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.59204799
25	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.57730321
26	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.57276476
27	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.56909709
28	TP53_22573176_ChIP-Seq_HFKS_Human	1.56037310
29	REST_21632747_ChIP-Seq_MESCs_Mouse	1.55234104
30	BCAT_22108803_ChIP-Seq_LS180_Human	1.54960048
31	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.54202907
32	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.52853390
33	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.50146886
34	SMAD4_21799915_ChIP-Seq_A2780_Human	1.49931490
35	IRF1_19129219_ChIP-ChIP_H3396_Human	1.48287433
36	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.47827762
37	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.46607139
38	AR_25329375_ChIP-Seq_VCAP_Human	1.46550308
39	STAT3_23295773_ChIP-Seq_U87_Human	1.45898270
40	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.45503818
41	CBP_20019798_ChIP-Seq_JUKART_Human	1.45365738
42	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.45365738
43	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.43640186
44	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.42700940
45	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.37689630
46	TCF4_23295773_ChIP-Seq_U87_Human	1.36052371
47	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.35452357
48	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.34684151
49	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.34286159
50	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.33992009
51	RNF2_27304074_Chip-Seq_NSC_Mouse	1.32771435
52	* FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.30926675
53	* FOXA1_25329375_ChIP-Seq_VCAP_Human	1.30926675
54	NANOG_19829295_ChIP-Seq_ESCs_Human	1.30876033
55	SOX2_19829295_ChIP-Seq_ESCs_Human	1.30876033
56	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.30651888
57	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.29850158
58	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.29761148
59	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.28437490
60	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.28437490
61	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.28018789
62	RUNX2_22187159_ChIP-Seq_PCA_Human	1.26256177
63	TCF4_22108803_ChIP-Seq_LS180_Human	1.25637725
64	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.22669463
65	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.22444790
66	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.21179551
67	NCOR_22424771_ChIP-Seq_293T_Human	1.17822257
68	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.17706096
69	* FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.17692835
70	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.16933301
71	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.16641778
72	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.15816656
73	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.15722416
74	AR_20517297_ChIP-Seq_VCAP_Human	1.15693021
75	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.15533154
76	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.15113075
77	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.14605233
78	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.13768672
79	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.13026488
80	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.12394640
81	* MYC_18940864_ChIP-ChIP_HL60_Human	1.10558629
82	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.09920615
83	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.08923260
84	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.06735985
85	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.05912864
86	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.05731969
87	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.04918596
88	AR_21572438_ChIP-Seq_LNCaP_Human	1.04893394
89	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.04151684
90	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.03803586
91	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.02073322
92	MYC_19829295_ChIP-Seq_ESCs_Human	1.01600518
93	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.01030970
94	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.00147211
95	HOXB7_26014856_ChIP-Seq_BT474_Human	0.99967012
96	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.99733042
97	P53_22387025_ChIP-Seq_ESCs_Mouse	0.99653372
98	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.96719202
99	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.96114622
100	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.95913428

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	2.62275305
2	MP0008877_abnormal_DNA_methylation	2.50274989
3	MP0005551_abnormal_eye_electrophysiolog	2.43613763
4	MP0003880_abnormal_central_pattern	2.36868506
5	MP0003195_calcinosis	2.36668237
6	MP0002876_abnormal_thyroid_physiology	2.33120205
7	MP0005645_abnormal_hypothalamus_physiol	2.30873018
8	MP0003646_muscle_fatigue	2.29625652
9	MP0002837_dystrophic_cardiac_calcinosis	2.28470155
10	MP0006072_abnormal_retinal_apoptosis	2.23987720
11	MP0003787_abnormal_imprinting	2.21343260
12	MP0009745_abnormal_behavioral_response	2.06398770
13	MP0008875_abnormal_xenobiotic_pharmacok	2.04870469
14	MP0001986_abnormal_taste_sensitivity	2.02762955
15	MP0001968_abnormal_touch/_nociception	1.99739106
16	MP0009046_muscle_twitch	1.98054621
17	MP0000569_abnormal_digit_pigmentation	1.94611489
18	MP0004043_abnormal_pH_regulation	1.91458468
19	MP0005646_abnormal_pituitary_gland	1.90376859
20	MP0008872_abnormal_physiological_respon	1.86861205
21	MP0006276_abnormal_autonomic_nervous	1.83054177
22	MP0004133_heterotaxia	1.80512651
23	MP0004885_abnormal_endolymph	1.77297986
24	MP0002638_abnormal_pupillary_reflex	1.77215759
25	MP0004142_abnormal_muscle_tone	1.75543764
26	MP0002272_abnormal_nervous_system	1.71897245
27	MP0001984_abnormal_olfaction	1.69085755
28	MP0006292_abnormal_olfactory_placode	1.65799789
29	MP0005253_abnormal_eye_physiology	1.64299156
30	MP0003283_abnormal_digestive_organ	1.63307822
31	MP0004147_increased_porphyrin_level	1.63255029
32	MP0002938_white_spotting	1.59599749
33	MP0002736_abnormal_nociception_after	1.54484182
34	MP0002163_abnormal_gland_morphology	1.53069580
35	MP0000631_abnormal_neuroendocrine_gland	1.52501374
36	MP0001485_abnormal_pinna_reflex	1.46479143
37	MP0002064_seizures	1.42401414
38	MP0000372_irregular_coat_pigmentation	1.41380434
39	MP0001501_abnormal_sleep_pattern	1.40833117
40	MP0002653_abnormal_ependyma_morphology	1.40503786
41	MP0005389_reproductive_system_phenotype	1.40129829
42	MP0003136_yellow_coat_color	1.37865535
43	MP0004742_abnormal_vestibular_system	1.34782091
44	MP0001486_abnormal_startle_reflex	1.34255486
45	MP0000427_abnormal_hair_cycle	1.33514146
46	MP0002160_abnormal_reproductive_system	1.31935236
47	MP0002572_abnormal_emotion/affect_behav	1.30063318
48	MP0002277_abnormal_respiratory_mucosa	1.29775683
49	MP0001970_abnormal_pain_threshold	1.26947589
50	MP0005423_abnormal_somatic_nervous	1.24483076
51	MP0005379_endocrine/exocrine_gland_phen	1.23126137
52	MP0001919_abnormal_reproductive_system	1.22667069
53	MP0003011_delayed_dark_adaptation	1.21507844
54	MP0002234_abnormal_pharynx_morphology	1.19172966
55	MP0004145_abnormal_muscle_electrophysio	1.18337629
56	MP0005084_abnormal_gallbladder_morpholo	1.17711401
57	MP0002557_abnormal_social/conspecific_i	1.17511551
58	MP0002735_abnormal_chemical_nociception	1.16906246
59	MP0002928_abnormal_bile_duct	1.16361418
60	MP0002067_abnormal_sensory_capabilities	1.15278822
61	MP0005174_abnormal_tail_pigmentation	1.15114402
62	MP0002733_abnormal_thermal_nociception	1.14974140
63	MP0003122_maternal_imprinting	1.11235032
64	MP0000383_abnormal_hair_follicle	1.09669918
65	MP0003121_genomic_imprinting	1.07746298
66	MP0000778_abnormal_nervous_system	1.06489750
67	MP0008789_abnormal_olfactory_epithelium	1.06385824
68	MP0005195_abnormal_posterior_eye	1.05670575
69	MP0003635_abnormal_synaptic_transmissio	1.04004210
70	MP0002063_abnormal_learning/memory/cond	1.02459066
71	MP0000566_synostosis	1.02078019
72	MP0002909_abnormal_adrenal_gland	1.00815661
73	MP0001529_abnormal_vocalization	1.00572196
74	MP0005386_behavior/neurological_phenoty	0.98934830
75	MP0004924_abnormal_behavior	0.98934830
76	MP0005410_abnormal_fertilization	0.97396707
77	MP0008775_abnormal_heart_ventricle	0.97296934
78	MP0008995_early_reproductive_senescence	0.95158943
79	MP0002095_abnormal_skin_pigmentation	0.94551085
80	MP0002752_abnormal_somatic_nervous	0.91858487
81	MP0001905_abnormal_dopamine_level	0.91323544
82	MP0002184_abnormal_innervation	0.91049551
83	MP0000026_abnormal_inner_ear	0.90698979
84	MP0005075_abnormal_melanosome_morpholog	0.89969415
85	MP0003878_abnormal_ear_physiology	0.87702941
86	MP0005377_hearing/vestibular/ear_phenot	0.87702941
87	MP0002734_abnormal_mechanical_nocicepti	0.87666938
88	MP0002138_abnormal_hepatobiliary_system	0.86828309
89	MP0000955_abnormal_spinal_cord	0.86371303
90	MP0005085_abnormal_gallbladder_physiolo	0.86327564
91	MP0003890_abnormal_embryonic-extraembry	0.85714553
92	MP0002229_neurodegeneration	0.84439251
93	MP0010386_abnormal_urinary_bladder	0.84316950
94	MP0003698_abnormal_male_reproductive	0.84038255
95	MP0005332_abnormal_amino_acid	0.83107603
96	MP0005167_abnormal_blood-brain_barrier	0.82082480
97	MP0002751_abnormal_autonomic_nervous	0.81078844
98	MP0003252_abnormal_bile_duct	0.80956581
99	MP0001440_abnormal_grooming_behavior	0.79615983
100	MP0004215_abnormal_myocardial_fiber	0.78347390

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.56524926
2	Type II lissencephaly (HP:0007260)	4.30565847
3	Abnormality of midbrain morphology (HP:0002418)	4.24326802
4	Molar tooth sign on MRI (HP:0002419)	4.24326802
5	Pancreatic fibrosis (HP:0100732)	4.22822961
6	Congenital stationary night blindness (HP:0007642)	4.04428438
7	Nephronophthisis (HP:0000090)	4.02371394
8	True hermaphroditism (HP:0010459)	3.95696823
9	Abnormality of the renal medulla (HP:0100957)	3.42966957
10	Cerebellar dysplasia (HP:0007033)	3.41855608
11	Abnormality of the renal cortex (HP:0011035)	3.37133053
12	Medial flaring of the eyebrow (HP:0010747)	3.26326900
13	Abolished electroretinogram (ERG) (HP:0000550)	3.11306123
14	Abnormal respiratory epithelium morphology (HP:0012253)	3.01046813
15	Abnormal respiratory motile cilium morphology (HP:0005938)	3.01046813
16	Tubular atrophy (HP:0000092)	3.01014190
17	Absent/shortened dynein arms (HP:0200106)	3.00928968
18	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.00928968
19	Polydipsia (HP:0001959)	2.94905040
20	Abnormal drinking behavior (HP:0030082)	2.94905040
21	Retinal dysplasia (HP:0007973)	2.86933839
22	Abnormal rod and cone electroretinograms (HP:0008323)	2.86010456
23	Chronic hepatic failure (HP:0100626)	2.84538878
24	Hyperventilation (HP:0002883)	2.75258985
25	Abnormal ciliary motility (HP:0012262)	2.72412965
26	Cystic liver disease (HP:0006706)	2.71966362
27	Gait imbalance (HP:0002141)	2.63716095
28	Attenuation of retinal blood vessels (HP:0007843)	2.57448676
29	Abnormal respiratory motile cilium physiology (HP:0012261)	2.54786826
30	Congenital primary aphakia (HP:0007707)	2.54760687
31	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.51456269
32	Hypothermia (HP:0002045)	2.50774917
33	Lissencephaly (HP:0001339)	2.50489519
34	Nephrogenic diabetes insipidus (HP:0009806)	2.45358070
35	Sclerocornea (HP:0000647)	2.43573394
36	Renal cortical cysts (HP:0000803)	2.38595809
37	Decreased circulating renin level (HP:0003351)	2.35683465
38	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.35339864
39	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.34245871
40	Congenital, generalized hypertrichosis (HP:0004540)	2.30693718
41	Congenital hepatic fibrosis (HP:0002612)	2.30281426
42	Inability to walk (HP:0002540)	2.30113086
43	Furrowed tongue (HP:0000221)	2.25637064
44	Polyuria (HP:0000103)	2.23741436
45	Hypoplasia of the pons (HP:0012110)	2.22666348
46	Severe muscular hypotonia (HP:0006829)	2.22446329
47	Anencephaly (HP:0002323)	2.21458444
48	Abnormality of the pons (HP:0007361)	2.21424831
49	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.18071575
50	Decreased central vision (HP:0007663)	2.15935753
51	Concave nail (HP:0001598)	2.11924629
52	Postaxial foot polydactyly (HP:0001830)	2.10644743
53	Abnormality of alanine metabolism (HP:0010916)	2.10398186
54	Hyperalaninemia (HP:0003348)	2.10398186
55	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.10398186
56	Pachygyria (HP:0001302)	2.09053302
57	Gaze-evoked nystagmus (HP:0000640)	2.08042012
58	Occipital encephalocele (HP:0002085)	2.07173226
59	Genital tract atresia (HP:0001827)	2.06442498
60	Rhinitis (HP:0012384)	2.05600025
61	3-Methylglutaconic aciduria (HP:0003535)	2.05346646
62	Bony spicule pigmentary retinopathy (HP:0007737)	2.05343249
63	Agitation (HP:0000713)	2.05278766
64	Keratoconus (HP:0000563)	2.05068159
65	Increased corneal curvature (HP:0100692)	2.05068159
66	Progressive inability to walk (HP:0002505)	2.04373836
67	Male pseudohermaphroditism (HP:0000037)	2.03589947
68	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.01545748
69	Stomatitis (HP:0010280)	2.01372164
70	Pendular nystagmus (HP:0012043)	2.00863455
71	Broad-based gait (HP:0002136)	1.98995303
72	Abnormal biliary tract physiology (HP:0012439)	1.98138219
73	Bile duct proliferation (HP:0001408)	1.98138219
74	Acute necrotizing encephalopathy (HP:0006965)	1.98051038
75	Hypoplasia of the fovea (HP:0007750)	1.97196424
76	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.97196424
77	Vaginal atresia (HP:0000148)	1.95393228
78	Large for gestational age (HP:0001520)	1.94985824
79	Ketoacidosis (HP:0001993)	1.94528414
80	Febrile seizures (HP:0002373)	1.94215850
81	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.93569582
82	Progressive macrocephaly (HP:0004481)	1.92516615
83	Mitochondrial inheritance (HP:0001427)	1.92053658
84	Postaxial hand polydactyly (HP:0001162)	1.90192101
85	Hypomagnesemia (HP:0002917)	1.89360037
86	Congenital sensorineural hearing impairment (HP:0008527)	1.88235350
87	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.88232596
88	Ketosis (HP:0001946)	1.87035965
89	Optic nerve hypoplasia (HP:0000609)	1.86032709
90	Stomach cancer (HP:0012126)	1.84246267
91	Progressive cerebellar ataxia (HP:0002073)	1.84051721
92	Aplasia/hypoplasia of the uterus (HP:0008684)	1.82175797
93	Increased CSF lactate (HP:0002490)	1.79964898
94	Abnormal urine output (HP:0012590)	1.77875236
95	Retinal atrophy (HP:0001105)	1.75948586
96	Poor coordination (HP:0002370)	1.73713152
97	Acute encephalopathy (HP:0006846)	1.73712414
98	Polyphagia (HP:0002591)	1.72204588
99	Tachypnea (HP:0002789)	1.70860853
100	Bronchiectasis (HP:0002110)	1.69800717

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.72057931
2	MAP4K2	3.49647468
3	ADRBK2	3.11099495
4	WNK4	2.93648484
5	PINK1	2.82582214
6	BMPR1B	2.75464593
7	ZAK	2.39799471
8	GRK1	2.37895737
9	TLK1	2.27450103
10	CASK	2.18248522
11	WNK3	2.16122217
12	TAOK3	2.01919998
13	STK39	1.85754623
14	ACVR1B	1.84724737
15	MAPK13	1.75947933
16	PNCK	1.70856358
17	MAP3K4	1.61060814
18	TXK	1.59666192
19	NUAK1	1.54660076
20	PAK3	1.49556310
21	INSRR	1.48647338
22	MARK1	1.32321343
23	DAPK2	1.31392548
24	OXSR1	1.31121123
25	MAPK15	1.29928672
26	CAMKK2	1.26354178
27	NTRK3	1.20359969
28	ADRBK1	1.14289783
29	DYRK2	1.14042089
30	MAP2K7	1.09018483
31	PRKCG	1.05011191
32	TNIK	1.02927849
33	MAPKAPK3	1.00227278
34	NTRK2	0.99577610
35	STK11	0.97529214
36	PRKCE	0.95058073
37	FGFR2	0.95054660
38	MKNK2	0.93984448
39	IRAK1	0.87499726
40	PHKG2	0.86093405
41	PHKG1	0.86093405
42	STK24	0.85566276
43	STK38L	0.84445626
44	PTK2B	0.83768813
45	MARK3	0.82857580
46	CSNK1G2	0.81632992
47	TRIM28	0.78799927
48	BCKDK	0.75780754
49	PLK2	0.71732443
50	TGFBR1	0.71470686
51	PRKCQ	0.68337086
52	EPHA3	0.67753158
53	BCR	0.66980812
54	CSNK1G3	0.66962123
55	TIE1	0.65846900
56	CSNK1G1	0.63364126
57	TNK2	0.62630990
58	CAMK1	0.61445458
59	MAP2K6	0.61286900
60	PASK	0.60403103
61	PIK3CA	0.59454601
62	VRK1	0.59050725
63	PKN1	0.55672927
64	CAMK2A	0.55388795
65	WEE1	0.53149952
66	MUSK	0.53080315
67	GRK7	0.52802470
68	BRSK2	0.51475936
69	IKBKB	0.50811466
70	CSNK1A1L	0.50525149
71	PRKACA	0.50120632
72	NME1	0.48921299
73	TEC	0.46927784
74	STK3	0.46087003
75	ERBB3	0.45762352
76	KIT	0.45241342
77	STK16	0.45164622
78	CSNK1A1	0.44921981
79	RPS6KA5	0.44139069
80	PRKCZ	0.44095536
81	CSNK1D	0.40842296
82	ITK	0.40723323
83	ERBB2	0.39543915
84	PRKCA	0.38665758
85	EPHA4	0.38382436
86	CHUK	0.38361874
87	DYRK1A	0.37790247
88	PRKCI	0.36198420
89	PRKAA1	0.35776124
90	SYK	0.35642464
91	MINK1	0.34716552
92	RPS6KA6	0.33942848
93	PLK4	0.33791254
94	OBSCN	0.33084937
95	PLK3	0.32711962
96	PRKAA2	0.32316162
97	WNK1	0.31851694
98	MAPKAPK5	0.31325861
99	TAF1	0.30814109
100	MAP2K4	0.29689224

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.97744426
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.60011943
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.51733755
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.44840747
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.42428260
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.36592725
7	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.33748582
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.28399185
9	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.26255100
10	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.24555041
11	Butanoate metabolism_Homo sapiens_hsa00650	2.20717407
12	Nicotine addiction_Homo sapiens_hsa05033	2.20667921
13	Protein export_Homo sapiens_hsa03060	1.93446222
14	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.92770284
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.84832012
16	Ether lipid metabolism_Homo sapiens_hsa00565	1.72889440
17	Parkinsons disease_Homo sapiens_hsa05012	1.72591153
18	Caffeine metabolism_Homo sapiens_hsa00232	1.67557129
19	Tryptophan metabolism_Homo sapiens_hsa00380	1.67011629
20	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.62749020
21	Selenocompound metabolism_Homo sapiens_hsa00450	1.60686406
22	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.52036034
23	Peroxisome_Homo sapiens_hsa04146	1.49407342
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.46346975
25	Basal transcription factors_Homo sapiens_hsa03022	1.42965048
26	Taste transduction_Homo sapiens_hsa04742	1.42951300
27	Olfactory transduction_Homo sapiens_hsa04740	1.41669704
28	Regulation of autophagy_Homo sapiens_hsa04140	1.40025207
29	Cardiac muscle contraction_Homo sapiens_hsa04260	1.33256239
30	Homologous recombination_Homo sapiens_hsa03440	1.32534135
31	Morphine addiction_Homo sapiens_hsa05032	1.29968502
32	Collecting duct acid secretion_Homo sapiens_hsa04966	1.29914530
33	Huntingtons disease_Homo sapiens_hsa05016	1.27597802
34	Propanoate metabolism_Homo sapiens_hsa00640	1.24115864
35	Fanconi anemia pathway_Homo sapiens_hsa03460	1.23885521
36	Insulin secretion_Homo sapiens_hsa04911	1.21916173
37	Alzheimers disease_Homo sapiens_hsa05010	1.20495012
38	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.18764046
39	Chemical carcinogenesis_Homo sapiens_hsa05204	1.16995452
40	Circadian entrainment_Homo sapiens_hsa04713	1.15015549
41	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.13744972
42	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.12324438
43	RNA polymerase_Homo sapiens_hsa03020	1.07766803
44	ABC transporters_Homo sapiens_hsa02010	1.06656263
45	Glutamatergic synapse_Homo sapiens_hsa04724	1.05659079
46	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.03930008
47	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.02731654
48	Retinol metabolism_Homo sapiens_hsa00830	1.02078404
49	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.00492074
50	Serotonergic synapse_Homo sapiens_hsa04726	1.00313483
51	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.00191188
52	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.99046635
53	GABAergic synapse_Homo sapiens_hsa04727	0.98004723
54	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.96641192
55	beta-Alanine metabolism_Homo sapiens_hsa00410	0.96006773
56	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.91489086
57	Salivary secretion_Homo sapiens_hsa04970	0.89301067
58	Primary immunodeficiency_Homo sapiens_hsa05340	0.87773084
59	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.87184356
60	RNA degradation_Homo sapiens_hsa03018	0.85171458
61	Histidine metabolism_Homo sapiens_hsa00340	0.83895928
62	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.82109687
63	Type I diabetes mellitus_Homo sapiens_hsa04940	0.79542474
64	Glycerolipid metabolism_Homo sapiens_hsa00561	0.77559259
65	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.77408203
66	Sulfur metabolism_Homo sapiens_hsa00920	0.76113239
67	One carbon pool by folate_Homo sapiens_hsa00670	0.72763252
68	Dopaminergic synapse_Homo sapiens_hsa04728	0.70427856
69	Asthma_Homo sapiens_hsa05310	0.68824717
70	Cocaine addiction_Homo sapiens_hsa05030	0.63226112
71	Mineral absorption_Homo sapiens_hsa04978	0.60452337
72	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.58968095
73	Steroid biosynthesis_Homo sapiens_hsa00100	0.58724243
74	Long-term depression_Homo sapiens_hsa04730	0.58551634
75	Metabolic pathways_Homo sapiens_hsa01100	0.56956762
76	Calcium signaling pathway_Homo sapiens_hsa04020	0.56622115
77	Fat digestion and absorption_Homo sapiens_hsa04975	0.56399385
78	Ribosome_Homo sapiens_hsa03010	0.54429473
79	Amphetamine addiction_Homo sapiens_hsa05031	0.54407635
80	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.53325786
81	Purine metabolism_Homo sapiens_hsa00230	0.52204329
82	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.48586984
83	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.46463256
84	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.46116193
85	Graft-versus-host disease_Homo sapiens_hsa05332	0.44201555
86	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.44085659
87	Allograft rejection_Homo sapiens_hsa05330	0.43581522
88	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.43039782
89	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.42850521
90	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.42391621
91	Circadian rhythm_Homo sapiens_hsa04710	0.40632735
92	Cholinergic synapse_Homo sapiens_hsa04725	0.37214021
93	cAMP signaling pathway_Homo sapiens_hsa04024	0.37125756
94	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.37043048
95	Rheumatoid arthritis_Homo sapiens_hsa05323	0.36390593
96	Fatty acid degradation_Homo sapiens_hsa00071	0.34256814
97	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.30179940
98	Renin secretion_Homo sapiens_hsa04924	0.29841048
99	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.29450727
100	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.29423056

ZNF396

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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