ZNF397

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with a N-terminal SCAN domain, and the longer isoform contains nine C2H2-type zinc finger repeats in the C-terminal domain. The protein localizes to centromeres during interphase and early prophase, and different isoforms can repress or activate transcription in transfection studies. Multiple transcript variants encoding different isoforms have been found for this gene. Additional variants have been described, but their biological validity has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.35056511
2pyrimidine nucleobase catabolic process (GO:0006208)4.01763695
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.95802009
4water-soluble vitamin biosynthetic process (GO:0042364)3.76746029
5gamma-aminobutyric acid transport (GO:0015812)3.76358300
6presynaptic membrane assembly (GO:0097105)3.61063720
7somite development (GO:0061053)3.51112092
8nonmotile primary cilium assembly (GO:0035058)3.48918862
9negative regulation of transcription regulatory region DNA binding (GO:2000678)3.41348502
10negative regulation of translation, ncRNA-mediated (GO:0040033)3.40734407
11regulation of translation, ncRNA-mediated (GO:0045974)3.40734407
12negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.40734407
13membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.40026553
14cell proliferation in forebrain (GO:0021846)3.36589615
15sulfation (GO:0051923)3.36191258
16neural tube formation (GO:0001841)3.36103253
17epithelial cilium movement (GO:0003351)3.32948589
18kidney morphogenesis (GO:0060993)3.30679377
19fucose catabolic process (GO:0019317)3.30338759
20L-fucose metabolic process (GO:0042354)3.30338759
21L-fucose catabolic process (GO:0042355)3.30338759
22transmission of nerve impulse (GO:0019226)3.26266221
23nucleobase catabolic process (GO:0046113)3.23924008
24presynaptic membrane organization (GO:0097090)3.23750185
25response to pheromone (GO:0019236)3.23110801
26indolalkylamine metabolic process (GO:0006586)3.20810635
27protein complex biogenesis (GO:0070271)3.19325838
28regulation of posttranscriptional gene silencing (GO:0060147)3.14050467
29regulation of gene silencing by miRNA (GO:0060964)3.14050467
30regulation of gene silencing by RNA (GO:0060966)3.14050467
31protein polyglutamylation (GO:0018095)3.11564047
32otic vesicle formation (GO:0030916)3.04511250
33serotonin metabolic process (GO:0042428)3.02539965
34mitochondrial respiratory chain complex I assembly (GO:0032981)2.99032025
35NADH dehydrogenase complex assembly (GO:0010257)2.99032025
36mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.99032025
37dendritic spine morphogenesis (GO:0060997)2.98086010
38primary amino compound metabolic process (GO:1901160)2.94730926
39spinal cord motor neuron differentiation (GO:0021522)2.93832165
40cilium movement (GO:0003341)2.90280134
41mitochondrial respiratory chain complex assembly (GO:0033108)2.89442918
42retinal ganglion cell axon guidance (GO:0031290)2.80700502
43axoneme assembly (GO:0035082)2.77516097
44detection of light stimulus involved in sensory perception (GO:0050962)2.76774327
45detection of light stimulus involved in visual perception (GO:0050908)2.76774327
46tryptophan catabolic process (GO:0006569)2.76603028
47indole-containing compound catabolic process (GO:0042436)2.76603028
48indolalkylamine catabolic process (GO:0046218)2.76603028
49platelet dense granule organization (GO:0060155)2.76226764
50spinal cord development (GO:0021510)2.76111173
51cilium morphogenesis (GO:0060271)2.75639927
52limb bud formation (GO:0060174)2.74777005
53hindbrain development (GO:0030902)2.73690608
54negative regulation of telomere maintenance (GO:0032205)2.73005563
55limb development (GO:0060173)2.72957294
56appendage development (GO:0048736)2.72957294
57kynurenine metabolic process (GO:0070189)2.72849708
58positive regulation of oligodendrocyte differentiation (GO:0048714)2.71971764
59cilium organization (GO:0044782)2.67149131
60postsynaptic membrane organization (GO:0001941)2.65947627
61negative regulation of response to food (GO:0032096)2.65009310
62negative regulation of appetite (GO:0032099)2.65009310
63forebrain neuron differentiation (GO:0021879)2.63211231
64indole-containing compound metabolic process (GO:0042430)2.63102679
65regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.62410593
66cell differentiation in spinal cord (GO:0021515)2.62227925
67negative regulation of systemic arterial blood pressure (GO:0003085)2.60239971
68regulation of action potential (GO:0098900)2.60044857
69intraciliary transport (GO:0042073)2.58764268
70protein localization to cilium (GO:0061512)2.58458719
71membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.56401170
72cilium assembly (GO:0042384)2.55336933
73detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.54045675
74neuron fate determination (GO:0048664)2.53801697
75G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.53516907
76head development (GO:0060322)2.53129409
77dentate gyrus development (GO:0021542)2.52256047
78photoreceptor cell development (GO:0042461)2.51080276
79regulation of cilium movement (GO:0003352)2.50995225
80DNA deamination (GO:0045006)2.50486074
81regulation of mesoderm development (GO:2000380)2.48594656
82neuronal action potential (GO:0019228)2.48439023
83negative regulation of cytosolic calcium ion concentration (GO:0051481)2.46535458
84purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.46434194
853-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.46434194
86behavioral response to ethanol (GO:0048149)2.45350665
87synaptic transmission, cholinergic (GO:0007271)2.44608845
88reflex (GO:0060004)2.44517672
89regulation of telomere maintenance (GO:0032204)2.44278309
90olfactory bulb development (GO:0021772)2.43582718
91replication fork processing (GO:0031297)2.41451061
92monoubiquitinated protein deubiquitination (GO:0035520)2.41436473
93neuromuscular synaptic transmission (GO:0007274)2.41070524
94synapse assembly (GO:0007416)2.40841311
95forebrain morphogenesis (GO:0048853)2.40141426
96negative regulation of synaptic transmission, GABAergic (GO:0032229)2.39439005
97membrane depolarization during action potential (GO:0086010)2.37640921
98regulation of collateral sprouting (GO:0048670)2.37062053
99neuron cell-cell adhesion (GO:0007158)2.36238715
100negative regulation of astrocyte differentiation (GO:0048712)2.36059887

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.62081441
2ZNF274_21170338_ChIP-Seq_K562_Hela3.47803544
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.03954347
4GBX2_23144817_ChIP-Seq_PC3_Human2.87664929
5VDR_22108803_ChIP-Seq_LS180_Human2.86752676
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.53633432
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.51969635
8IGF1R_20145208_ChIP-Seq_DFB_Human2.47571203
9FUS_26573619_Chip-Seq_HEK293_Human2.23691163
10TAF15_26573619_Chip-Seq_HEK293_Human2.21023957
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.20335497
12* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.19999374
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.19433910
14* EWS_26573619_Chip-Seq_HEK293_Human2.08861550
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.04483538
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.99969315
17P300_19829295_ChIP-Seq_ESCs_Human1.97114573
18IRF1_19129219_ChIP-ChIP_H3396_Human1.96798553
19CBX2_27304074_Chip-Seq_ESCs_Mouse1.95138171
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.87362433
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.83583625
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75740924
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.71190828
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.70354103
25REST_21632747_ChIP-Seq_MESCs_Mouse1.70042136
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68548689
27RNF2_27304074_Chip-Seq_NSC_Mouse1.66035225
28SALL1_21062744_ChIP-ChIP_HESCs_Human1.65801408
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61617057
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60863227
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59653239
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.59392323
33ER_23166858_ChIP-Seq_MCF-7_Human1.54868342
34MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.54757437
35POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.54417309
36TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54417309
37EZH2_27304074_Chip-Seq_ESCs_Mouse1.53745949
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.53646580
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51685418
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50825970
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.49103227
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46934871
43SMAD4_21799915_ChIP-Seq_A2780_Human1.46889162
44STAT3_23295773_ChIP-Seq_U87_Human1.46588592
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46559936
46* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43229441
47* CBP_20019798_ChIP-Seq_JUKART_Human1.43229441
48JARID2_20064375_ChIP-Seq_MESCs_Mouse1.42593388
49POU5F1_16153702_ChIP-ChIP_HESCs_Human1.40262600
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39322539
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36297266
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.34583050
53BCAT_22108803_ChIP-Seq_LS180_Human1.34194429
54* TCF4_23295773_ChIP-Seq_U87_Human1.33609407
55NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33357415
56FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.32829553
57AR_25329375_ChIP-Seq_VCAP_Human1.32232055
58SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.31487368
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30494512
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29595008
61SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.25762290
62AR_21572438_ChIP-Seq_LNCaP_Human1.25657330
63MYC_18940864_ChIP-ChIP_HL60_Human1.23136081
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23038897
65CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.20906418
66* TP53_22573176_ChIP-Seq_HFKS_Human1.19520048
67RUNX2_22187159_ChIP-Seq_PCA_Human1.18984588
68EZH2_27294783_Chip-Seq_ESCs_Mouse1.16678088
69REST_18959480_ChIP-ChIP_MESCs_Mouse1.15277406
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.15117222
71GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14523686
72SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.13374629
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13362421
74JARID2_20075857_ChIP-Seq_MESCs_Mouse1.12457036
75TCF4_22108803_ChIP-Seq_LS180_Human1.12206168
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12017279
77SUZ12_27294783_Chip-Seq_ESCs_Mouse1.09894737
78NCOR_22424771_ChIP-Seq_293T_Human1.07974232
79PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07201259
80BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.07115283
81NANOG_19829295_ChIP-Seq_ESCs_Human1.06969349
82SOX2_19829295_ChIP-Seq_ESCs_Human1.06969349
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06966031
84ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06490542
85TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06428227
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.05955268
87SMAD4_21741376_ChIP-Seq_EPCs_Human1.04206418
88RNF2_27304074_Chip-Seq_ESCs_Mouse1.03429279
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03368641
90PRDM14_20953172_ChIP-Seq_ESCs_Human1.02526963
91SOX2_21211035_ChIP-Seq_LN229_Gbm1.01146533
92EZH2_27294783_Chip-Seq_NPCs_Mouse1.00973787
93EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00866385
94NFE2_27457419_Chip-Seq_LIVER_Mouse1.00591408
95KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00560235
96FLI1_21867929_ChIP-Seq_TH2_Mouse1.00115122
97TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99127253
98TAL1_26923725_Chip-Seq_HPCs_Mouse0.99049700
99* TP63_19390658_ChIP-ChIP_HaCaT_Human0.98564422
100DROSHA_22980978_ChIP-Seq_HELA_Human0.97881938

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.09264787
2MP0003646_muscle_fatigue2.61501323
3MP0008877_abnormal_DNA_methylation2.59762426
4MP0000569_abnormal_digit_pigmentation2.37239718
5MP0002653_abnormal_ependyma_morphology2.34292999
6MP0003787_abnormal_imprinting2.23290402
7MP0003880_abnormal_central_pattern2.22689201
8MP0003136_yellow_coat_color2.22407394
9MP0002837_dystrophic_cardiac_calcinosis2.21663533
10MP0001968_abnormal_touch/_nociception2.11375458
11MP0001485_abnormal_pinna_reflex2.05488967
12MP0004133_heterotaxia2.00460609
13MP0004885_abnormal_endolymph1.97577466
14MP0005551_abnormal_eye_electrophysiolog1.96073304
15MP0000631_abnormal_neuroendocrine_gland1.94867507
16MP0002102_abnormal_ear_morphology1.94804872
17MP0003122_maternal_imprinting1.93584481
18MP0002638_abnormal_pupillary_reflex1.91343495
19MP0003195_calcinosis1.89801322
20MP0006072_abnormal_retinal_apoptosis1.84879332
21MP0002736_abnormal_nociception_after1.81882172
22MP0000778_abnormal_nervous_system1.81276088
23MP0009745_abnormal_behavioral_response1.80325612
24MP0004142_abnormal_muscle_tone1.69625042
25MP0002272_abnormal_nervous_system1.69080832
26MP0003890_abnormal_embryonic-extraembry1.67017711
27MP0009046_muscle_twitch1.66580230
28MP0003121_genomic_imprinting1.66545461
29MP0008789_abnormal_olfactory_epithelium1.65347825
30MP0002938_white_spotting1.63721239
31MP0001486_abnormal_startle_reflex1.62238206
32MP0006276_abnormal_autonomic_nervous1.62134325
33MP0003011_delayed_dark_adaptation1.55717668
34MP0000049_abnormal_middle_ear1.54008066
35MP0005646_abnormal_pituitary_gland1.51137173
36MP0005253_abnormal_eye_physiology1.49558761
37MP0002735_abnormal_chemical_nociception1.48511218
38MP0001984_abnormal_olfaction1.48305530
39MP0001529_abnormal_vocalization1.46011747
40MP0005645_abnormal_hypothalamus_physiol1.44823195
41MP0004742_abnormal_vestibular_system1.43777907
42MP0008995_early_reproductive_senescence1.42122582
43MP0002557_abnormal_social/conspecific_i1.41058562
44MP0002064_seizures1.40240696
45MP0002928_abnormal_bile_duct1.37244373
46MP0002572_abnormal_emotion/affect_behav1.36128478
47MP0004145_abnormal_muscle_electrophysio1.32724687
48MP0002160_abnormal_reproductive_system1.32570706
49MP0003635_abnormal_synaptic_transmissio1.31142291
50MP0002734_abnormal_mechanical_nocicepti1.29150769
51MP0001986_abnormal_taste_sensitivity1.28667512
52MP0008872_abnormal_physiological_respon1.27581713
53MP0005394_taste/olfaction_phenotype1.26318417
54MP0005499_abnormal_olfactory_system1.26318417
55MP0003938_abnormal_ear_development1.26280940
56MP0002063_abnormal_learning/memory/cond1.23747520
57MP0002733_abnormal_thermal_nociception1.23745076
58MP0000026_abnormal_inner_ear1.23223231
59MP0003119_abnormal_digestive_system1.20955689
60MP0005423_abnormal_somatic_nervous1.19685269
61MP0003937_abnormal_limbs/digits/tail_de1.19300240
62MP0002067_abnormal_sensory_capabilities1.19234295
63MP0001970_abnormal_pain_threshold1.18361676
64MP0004043_abnormal_pH_regulation1.17351693
65MP0002277_abnormal_respiratory_mucosa1.14165401
66MP0004924_abnormal_behavior1.13330832
67MP0005386_behavior/neurological_phenoty1.13330832
68MP0002752_abnormal_somatic_nervous1.12695827
69MP0002751_abnormal_autonomic_nervous1.11382008
70MP0005389_reproductive_system_phenotype1.09959776
71MP0002234_abnormal_pharynx_morphology1.06203964
72MP0001963_abnormal_hearing_physiology1.06197664
73MP0002184_abnormal_innervation1.05903991
74MP0001293_anophthalmia1.05786460
75MP0005174_abnormal_tail_pigmentation1.03444278
76MP0005195_abnormal_posterior_eye1.02179921
77MP0005377_hearing/vestibular/ear_phenot1.01599726
78MP0003878_abnormal_ear_physiology1.01599726
79MP0000955_abnormal_spinal_cord1.00571813
80MP0005084_abnormal_gallbladder_morpholo1.00063282
81MP0001501_abnormal_sleep_pattern0.98600205
82MP0004130_abnormal_muscle_cell0.98046973
83MP0010386_abnormal_urinary_bladder0.95846118
84MP0002163_abnormal_gland_morphology0.94901328
85MP0000427_abnormal_hair_cycle0.94457764
86MP0002882_abnormal_neuron_morphology0.94330433
87MP0001905_abnormal_dopamine_level0.89254853
88MP0003567_abnormal_fetal_cardiomyocyte0.88899901
89MP0005187_abnormal_penis_morphology0.87437351
90MP0001502_abnormal_circadian_rhythm0.86469599
91MP0003137_abnormal_impulse_conducting0.85880023
92MP0001440_abnormal_grooming_behavior0.85789101
93MP0004270_analgesia0.85546937
94MP0002876_abnormal_thyroid_physiology0.85435175
95MP0001188_hyperpigmentation0.85285807
96MP0000566_synostosis0.82671309
97MP0002152_abnormal_brain_morphology0.81400416
98MP0003283_abnormal_digestive_organ0.79808055
99MP0004859_abnormal_synaptic_plasticity0.79209864
100MP0002095_abnormal_skin_pigmentation0.76427897

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.24031991
2True hermaphroditism (HP:0010459)4.00204011
3Pancreatic fibrosis (HP:0100732)3.93685362
4Nephronophthisis (HP:0000090)3.72715607
5Molar tooth sign on MRI (HP:0002419)3.71961505
6Abnormality of midbrain morphology (HP:0002418)3.71961505
7Abnormality of the renal medulla (HP:0100957)3.14246659
8Congenital stationary night blindness (HP:0007642)3.08385568
9Progressive cerebellar ataxia (HP:0002073)3.06603978
10Medial flaring of the eyebrow (HP:0010747)2.98563827
11Genetic anticipation (HP:0003743)2.88349701
12Aplasia/Hypoplasia of the tibia (HP:0005772)2.77638515
13Abnormality of the renal cortex (HP:0011035)2.74411027
14Hyperventilation (HP:0002883)2.70322673
15Abolished electroretinogram (ERG) (HP:0000550)2.67964243
16Cystic liver disease (HP:0006706)2.64536433
17Chronic hepatic failure (HP:0100626)2.63270707
18Gait imbalance (HP:0002141)2.61075558
19Hyperglycinemia (HP:0002154)2.55827169
20Methylmalonic acidemia (HP:0002912)2.54688201
21Pendular nystagmus (HP:0012043)2.53399503
22Congenital primary aphakia (HP:0007707)2.49168704
23Gaze-evoked nystagmus (HP:0000640)2.48775767
24Septo-optic dysplasia (HP:0100842)2.40839743
25Short tibia (HP:0005736)2.38153098
26Anencephaly (HP:0002323)2.37704864
27Type II lissencephaly (HP:0007260)2.37670046
28Abnormality of the labia minora (HP:0012880)2.37443505
29Broad-based gait (HP:0002136)2.35791775
30Nephrogenic diabetes insipidus (HP:0009806)2.32684868
31Sclerocornea (HP:0000647)2.30462195
32Genital tract atresia (HP:0001827)2.30283327
33Vaginal atresia (HP:0000148)2.26510637
34Thyroid-stimulating hormone excess (HP:0002925)2.22624013
35Intestinal atresia (HP:0011100)2.22135965
36Inability to walk (HP:0002540)2.21052030
37Patellar aplasia (HP:0006443)2.17675841
38Optic nerve hypoplasia (HP:0000609)2.17416638
39Methylmalonic aciduria (HP:0012120)2.16426707
40Tubular atrophy (HP:0000092)2.15816657
41Agitation (HP:0000713)2.12901282
42Aplasia/Hypoplasia of the patella (HP:0006498)2.11618884
43Aplasia/Hypoplasia of the tongue (HP:0010295)2.09865985
44Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.08574092
45Decreased circulating renin level (HP:0003351)2.06751891
46Progressive inability to walk (HP:0002505)2.04711766
47Renal cortical cysts (HP:0000803)2.04245661
48Poor coordination (HP:0002370)2.02701901
49Congenital, generalized hypertrichosis (HP:0004540)2.01652794
50Lissencephaly (HP:0001339)2.01502700
51Furrowed tongue (HP:0000221)2.01299003
52Colon cancer (HP:0003003)2.00683490
53Attenuation of retinal blood vessels (HP:0007843)2.00138405
54Protruding tongue (HP:0010808)2.00097870
55Male pseudohermaphroditism (HP:0000037)2.00018013
56Postaxial foot polydactyly (HP:0001830)1.99614272
57Drooling (HP:0002307)1.99341633
58Absent/shortened dynein arms (HP:0200106)1.96502649
59Dynein arm defect of respiratory motile cilia (HP:0012255)1.96502649
60Abnormal ciliary motility (HP:0012262)1.95097092
61Congenital hepatic fibrosis (HP:0002612)1.92976253
62Abnormal respiratory motile cilium morphology (HP:0005938)1.91596046
63Abnormal respiratory epithelium morphology (HP:0012253)1.91596046
64Clumsiness (HP:0002312)1.91074466
65Abnormal rod and cone electroretinograms (HP:0008323)1.89546966
66Keratoconus (HP:0000563)1.87422940
67Increased corneal curvature (HP:0100692)1.87422940
68Abnormal biliary tract physiology (HP:0012439)1.86874082
69Bile duct proliferation (HP:0001408)1.86874082
70Abnormal drinking behavior (HP:0030082)1.85076486
71Polydipsia (HP:0001959)1.85076486
72Specific learning disability (HP:0001328)1.84299768
73Oligodactyly (hands) (HP:0001180)1.83232044
74Postaxial hand polydactyly (HP:0001162)1.82390977
75Abnormality of the renal collecting system (HP:0004742)1.80964665
76Concave nail (HP:0001598)1.80463897
77Excessive salivation (HP:0003781)1.79600587
78Decreased central vision (HP:0007663)1.78636784
79Pachygyria (HP:0001302)1.78623863
80Hemiparesis (HP:0001269)1.77900907
81Gastrointestinal atresia (HP:0002589)1.76984085
82Short 4th metacarpal (HP:0010044)1.74890241
83Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.74890241
84Chorioretinal atrophy (HP:0000533)1.74261595
85Preaxial hand polydactyly (HP:0001177)1.71836344
86Tachypnea (HP:0002789)1.71376661
87Aplasia/Hypoplasia of the spleen (HP:0010451)1.69952753
88Small hand (HP:0200055)1.68608543
89Abnormal respiratory motile cilium physiology (HP:0012261)1.67362494
90Cerebellar dysplasia (HP:0007033)1.66809107
91Hypoplasia of the pons (HP:0012110)1.66569074
92Rib fusion (HP:0000902)1.65649101
93Stenosis of the external auditory canal (HP:0000402)1.64764537
94Ectopic kidney (HP:0000086)1.64554920
95Focal seizures (HP:0007359)1.64401593
96Febrile seizures (HP:0002373)1.64267501
97Stomach cancer (HP:0012126)1.63977274
98Absent thumb (HP:0009777)1.63944267
99Dandy-Walker malformation (HP:0001305)1.63799277
100Bony spicule pigmentary retinopathy (HP:0007737)1.63555389

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.13836842
2WNK32.89603084
3CASK2.80501666
4MAP4K22.68688246
5ADRBK22.68307675
6BMPR1B2.48043205
7ZAK2.42501100
8MAP3K42.37645078
9GRK12.33507154
10INSRR2.27587887
11MAPK132.16381571
12PINK11.94964470
13MARK11.93155020
14ACVR1B1.83433139
15NUAK11.81294427
16DYRK21.73319134
17FGFR21.69299675
18TNIK1.68391256
19WNK41.68087967
20TRIM281.62673115
21EPHA31.59330881
22TAOK31.56103502
23MKNK21.52269088
24NTRK21.42482438
25MAP2K71.41559817
26NTRK31.39379190
27TLK11.28135830
28PNCK1.24795284
29PAK31.24157195
30MAPK151.20643135
31EPHA41.18360980
32CDK191.14803736
33PRKCG1.14103138
34BCR1.03079295
35OXSR11.02032223
36MKNK11.01929394
37STK391.00270908
38PLK20.93506633
39TXK0.93457590
40VRK10.90905876
41CSNK1G20.90322858
42DAPK20.89685634
43ADRBK10.88405270
44STK38L0.86329830
45TGFBR10.85282937
46PRKCE0.84830192
47CSNK1G10.84572325
48SGK20.83649471
49NLK0.83603986
50DYRK30.81891437
51STK110.80879756
52SGK2230.79372405
53SGK4940.79372405
54PLK40.79345033
55PKN10.74364511
56AKT30.73909424
57CSNK1G30.73848338
58CSNK1A1L0.71308887
59BCKDK0.67723323
60DYRK1A0.64255840
61PLK30.63663235
62MAP2K40.62134407
63ERBB20.59669395
64EPHB20.57877372
65RPS6KA50.57071611
66MUSK0.56263453
67PRKACA0.54782049
68PIK3CA0.54409052
69CAMK2A0.54135828
70PRKCZ0.53435240
71OBSCN0.52943961
72CAMK10.51683765
73PASK0.50551449
74ERBB30.50380810
75BRSK20.49410042
76CSNK1A10.49337877
77CDC70.47635283
78PRKCQ0.46431925
79ATR0.45743097
80SGK10.44657556
81TIE10.44222880
82MAPKAPK50.44175845
83CSNK1D0.43167379
84SIK20.40004871
85TEC0.39430044
86PHKG10.38667355
87PHKG20.38667355
88PLK10.37727819
89CHUK0.36863134
90CAMK40.35683435
91PRKCH0.35389117
92TAF10.35221515
93WEE10.35142293
94NEK20.34973040
95ATM0.33645169
96CDK50.33231278
97STK160.33178309
98TYRO30.32791239
99PRKG10.32662280
100CDK30.32608830

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.08771426
2Phototransduction_Homo sapiens_hsa047442.88547621
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.29280914
4Linoleic acid metabolism_Homo sapiens_hsa005912.24059626
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.21086181
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.13660223
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.12713946
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.12072826
9Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.09349480
10Butanoate metabolism_Homo sapiens_hsa006502.02187189
11Oxidative phosphorylation_Homo sapiens_hsa001902.00384976
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.98548290
13Basal transcription factors_Homo sapiens_hsa030221.86775191
14Nitrogen metabolism_Homo sapiens_hsa009101.82694421
15Fanconi anemia pathway_Homo sapiens_hsa034601.78262252
16Homologous recombination_Homo sapiens_hsa034401.77232194
17Taste transduction_Homo sapiens_hsa047421.71523700
18Morphine addiction_Homo sapiens_hsa050321.69118939
19Protein export_Homo sapiens_hsa030601.64496753
20Ether lipid metabolism_Homo sapiens_hsa005651.62233128
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.58790835
22RNA polymerase_Homo sapiens_hsa030201.56300995
23Parkinsons disease_Homo sapiens_hsa050121.56236074
24GABAergic synapse_Homo sapiens_hsa047271.55971956
25Selenocompound metabolism_Homo sapiens_hsa004501.52974027
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.50219086
27Tryptophan metabolism_Homo sapiens_hsa003801.49525030
28Glutamatergic synapse_Homo sapiens_hsa047241.46177578
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.45382537
30Circadian entrainment_Homo sapiens_hsa047131.44843033
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.43994832
32Olfactory transduction_Homo sapiens_hsa047401.42454553
33RNA degradation_Homo sapiens_hsa030181.41893407
34Insulin secretion_Homo sapiens_hsa049111.35048801
35Cardiac muscle contraction_Homo sapiens_hsa042601.34265707
36Serotonergic synapse_Homo sapiens_hsa047261.28614464
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.25121207
38Propanoate metabolism_Homo sapiens_hsa006401.22896264
39Steroid biosynthesis_Homo sapiens_hsa001001.16474923
40Peroxisome_Homo sapiens_hsa041461.12513550
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.12229114
42Huntingtons disease_Homo sapiens_hsa050161.12166534
43Retinol metabolism_Homo sapiens_hsa008301.09018242
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.07153712
45Caffeine metabolism_Homo sapiens_hsa002321.05786842
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.05419440
47ABC transporters_Homo sapiens_hsa020101.04410789
48Dopaminergic synapse_Homo sapiens_hsa047281.03391089
49Basal cell carcinoma_Homo sapiens_hsa052171.01800553
50Ribosome_Homo sapiens_hsa030100.99319495
51Alzheimers disease_Homo sapiens_hsa050100.97240008
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.95244750
53Hedgehog signaling pathway_Homo sapiens_hsa043400.91744359
54Regulation of autophagy_Homo sapiens_hsa041400.89329899
55Cholinergic synapse_Homo sapiens_hsa047250.89272712
56Chemical carcinogenesis_Homo sapiens_hsa052040.87972079
57Cocaine addiction_Homo sapiens_hsa050300.86818825
58Amphetamine addiction_Homo sapiens_hsa050310.86628310
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84508214
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.81880930
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81103667
62Axon guidance_Homo sapiens_hsa043600.81099488
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79868175
64Vitamin digestion and absorption_Homo sapiens_hsa049770.77820228
65Type II diabetes mellitus_Homo sapiens_hsa049300.77112233
66Calcium signaling pathway_Homo sapiens_hsa040200.76830529
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76437736
68Ovarian steroidogenesis_Homo sapiens_hsa049130.74651450
69Glycerolipid metabolism_Homo sapiens_hsa005610.72571185
70Arachidonic acid metabolism_Homo sapiens_hsa005900.72026134
71Sulfur metabolism_Homo sapiens_hsa009200.70752709
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68085070
73cAMP signaling pathway_Homo sapiens_hsa040240.66327271
74beta-Alanine metabolism_Homo sapiens_hsa004100.66288439
75One carbon pool by folate_Homo sapiens_hsa006700.66153648
76Fat digestion and absorption_Homo sapiens_hsa049750.62645987
77Collecting duct acid secretion_Homo sapiens_hsa049660.61034726
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58452335
79Long-term depression_Homo sapiens_hsa047300.57992509
80Salivary secretion_Homo sapiens_hsa049700.54713352
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53306268
82Purine metabolism_Homo sapiens_hsa002300.52860954
83Dorso-ventral axis formation_Homo sapiens_hsa043200.48567380
84Circadian rhythm_Homo sapiens_hsa047100.47152590
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46698917
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.46689207
87Hippo signaling pathway_Homo sapiens_hsa043900.46136045
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45721653
89Metabolic pathways_Homo sapiens_hsa011000.45223314
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.45092409
91Gastric acid secretion_Homo sapiens_hsa049710.45074710
92Oxytocin signaling pathway_Homo sapiens_hsa049210.44120100
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41955008
94Primary immunodeficiency_Homo sapiens_hsa053400.40032232
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35592194
96Sulfur relay system_Homo sapiens_hsa041220.35514879
97Renin secretion_Homo sapiens_hsa049240.32650660
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31902282
99Histidine metabolism_Homo sapiens_hsa003400.31828684
100Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31431891

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