ZNF398

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Kruppel family of C2H2-type zinc-finger transcription factor proteins. The encoded protein acts as a transcriptional activator. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described, but their full length sequence has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.89439714
2nuclear pore organization (GO:0006999)5.87609531
3pre-miRNA processing (GO:0031054)5.79970593
4regulation of gene silencing by miRNA (GO:0060964)5.20673756
5regulation of gene silencing by RNA (GO:0060966)5.20673756
6regulation of posttranscriptional gene silencing (GO:0060147)5.20673756
7mitotic sister chromatid cohesion (GO:0007064)5.00648233
8pore complex assembly (GO:0046931)4.85516148
9regulation of histone H3-K9 methylation (GO:0051570)4.72775552
10DNA unwinding involved in DNA replication (GO:0006268)4.63987829
11DNA replication checkpoint (GO:0000076)4.50542015
12protein complex localization (GO:0031503)4.44440167
13mitotic chromosome condensation (GO:0007076)4.41791634
14negative regulation of histone methylation (GO:0031061)4.12047447
15negative regulation of translation, ncRNA-mediated (GO:0040033)4.11133478
16regulation of translation, ncRNA-mediated (GO:0045974)4.11133478
17negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.11133478
18heterochromatin organization (GO:0070828)3.97743344
19regulation of RNA export from nucleus (GO:0046831)3.91709760
20protein localization to chromosome, centromeric region (GO:0071459)3.90618658
21cellular protein complex localization (GO:0034629)3.90082575
22DNA synthesis involved in DNA repair (GO:0000731)3.82494338
23histone H3-K36 demethylation (GO:0070544)3.82425276
24negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.82018548
25positive regulation of SMAD protein import into nucleus (GO:0060391)3.80862569
26protein localization to kinetochore (GO:0034501)3.73778846
27negative regulation of chromosome segregation (GO:0051985)3.52283415
28negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.48547109
29negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.48547109
30negative regulation of mitotic sister chromatid segregation (GO:0033048)3.48547109
31negative regulation of mitotic sister chromatid separation (GO:2000816)3.48547109
32negative regulation of sister chromatid segregation (GO:0033046)3.48547109
33regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.47547203
34mitotic metaphase plate congression (GO:0007080)3.37757939
35regulation of gene silencing (GO:0060968)3.35768682
36negative regulation of mRNA processing (GO:0050686)3.35182573
37sister chromatid segregation (GO:0000819)3.32086306
38mitotic sister chromatid segregation (GO:0000070)3.31409348
39negative regulation of mRNA metabolic process (GO:1903312)3.28492093
40DNA duplex unwinding (GO:0032508)3.27900225
41embryonic body morphogenesis (GO:0010172)3.26902167
42negative regulation of RNA splicing (GO:0033119)3.24497135
43chromatin assembly (GO:0031497)3.23719765
44DNA strand elongation involved in DNA replication (GO:0006271)3.22955351
45DNA strand elongation (GO:0022616)3.22632192
46regulation of centriole replication (GO:0046599)3.17294941
47maturation of SSU-rRNA (GO:0030490)3.14651354
48regulation of sister chromatid segregation (GO:0033045)3.14624976
49regulation of mitotic sister chromatid separation (GO:0010965)3.14624976
50regulation of mitotic sister chromatid segregation (GO:0033047)3.14624976
51DNA geometric change (GO:0032392)3.13132808
52regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.12677223
53regulation of mitotic metaphase/anaphase transition (GO:0030071)3.12677223
54regulation of cell fate specification (GO:0042659)3.11410708
55sister chromatid cohesion (GO:0007062)3.09428096
56regulation of chromosome segregation (GO:0051983)3.09047839
57DNA replication initiation (GO:0006270)3.09005060
58mitotic spindle assembly checkpoint (GO:0007094)3.07433475
59ribosomal small subunit biogenesis (GO:0042274)3.06519573
60regulation of nucleobase-containing compound transport (GO:0032239)3.05114927
61chromatin remodeling at centromere (GO:0031055)3.04928206
62mitotic spindle checkpoint (GO:0071174)3.02455700
63spindle assembly checkpoint (GO:0071173)3.01253823
64DNA replication-independent nucleosome organization (GO:0034724)3.01182648
65DNA replication-independent nucleosome assembly (GO:0006336)3.01182648
66L-serine metabolic process (GO:0006563)3.00803901
67regulation of chromatin silencing (GO:0031935)2.99852840
68regulation of histone methylation (GO:0031060)2.99781908
69mitotic nuclear envelope disassembly (GO:0007077)2.99069504
70negative regulation of fibroblast apoptotic process (GO:2000270)2.98774146
71DNA topological change (GO:0006265)2.98465025
72spindle checkpoint (GO:0031577)2.98193358
73chromatin assembly or disassembly (GO:0006333)2.97518046
74DNA replication-dependent nucleosome organization (GO:0034723)2.97292385
75DNA replication-dependent nucleosome assembly (GO:0006335)2.97292385
76positive regulation of chromosome segregation (GO:0051984)2.95998856
77positive regulation of histone methylation (GO:0031062)2.95224107
78CENP-A containing nucleosome assembly (GO:0034080)2.92460206
79spliceosomal tri-snRNP complex assembly (GO:0000244)2.90720704
80membrane disassembly (GO:0030397)2.89087405
81nuclear envelope disassembly (GO:0051081)2.89087405
82regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.88513230
83regulation of stem cell maintenance (GO:2000036)2.86495352
84ATP-dependent chromatin remodeling (GO:0043044)2.86448680
85regulation of helicase activity (GO:0051095)2.82871128
86DNA conformation change (GO:0071103)2.79976151
87regulation of DNA methylation (GO:0044030)2.79223394
88RNA stabilization (GO:0043489)2.78355687
89mRNA stabilization (GO:0048255)2.78355687
90regulation of DNA damage checkpoint (GO:2000001)2.78023275
91formation of translation preinitiation complex (GO:0001731)2.77182323
92protein-DNA complex disassembly (GO:0032986)2.76520096
93nucleosome disassembly (GO:0006337)2.76520096
94negative regulation of gene silencing (GO:0060969)2.76280511
95regulation of DNA endoreduplication (GO:0032875)2.73090971
96regulation of SMAD protein import into nucleus (GO:0060390)2.72996521
97paraxial mesoderm development (GO:0048339)2.70628958
98establishment of integrated proviral latency (GO:0075713)2.68096260
99regulation of chromatin binding (GO:0035561)2.67495175
100regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.67226444

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.99906720
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.93870212
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.29568548
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.71258333
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.10681851
6KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.94341052
7NOTCH1_21737748_ChIP-Seq_TLL_Human2.83067695
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.80248340
9E2F1_21310950_ChIP-Seq_MCF-7_Human2.78765998
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.62399941
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.57092122
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.52234408
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.49941480
14MYC_22102868_ChIP-Seq_BL_Human2.36998191
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.35172468
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.21589494
17KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.21111610
18KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.21111610
19KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.21111610
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.19369215
21POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.12806177
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.04754105
23POU5F1_16153702_ChIP-ChIP_HESCs_Human2.03316619
24MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.02870023
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.02438825
26MYCN_18555785_ChIP-Seq_MESCs_Mouse2.00723341
27NELFA_20434984_ChIP-Seq_ESCs_Mouse1.98431037
28AR_21909140_ChIP-Seq_LNCAP_Human1.97487259
29* XRN2_22483619_ChIP-Seq_HELA_Human1.95907065
30SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.89865662
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.87390910
32TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.85591575
33YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.84419735
34SOX2_16153702_ChIP-ChIP_HESCs_Human1.82745017
35SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.80747889
36MYC_18358816_ChIP-ChIP_MESCs_Mouse1.76989095
37CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.73724717
38TTF2_22483619_ChIP-Seq_HELA_Human1.69111658
39TP63_19390658_ChIP-ChIP_HaCaT_Human1.64993780
40CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.64001082
41ZFX_18555785_ChIP-Seq_MESCs_Mouse1.63315522
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.62356446
43NANOG_18555785_ChIP-Seq_MESCs_Mouse1.61384039
44RBPJ_22232070_ChIP-Seq_NCS_Mouse1.58486895
45* NANOG_16153702_ChIP-ChIP_HESCs_Human1.58370803
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56292458
47SOX2_18555785_ChIP-Seq_MESCs_Mouse1.54940574
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.46986653
49NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.44481301
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43398883
51GATA1_26923725_Chip-Seq_HPCs_Mouse1.42353384
52KDM5A_27292631_Chip-Seq_BREAST_Human1.41354418
53* CHD1_26751641_Chip-Seq_LNCaP_Human1.31414580
54TCF3_18692474_ChIP-Seq_MEFs_Mouse1.29802408
55TCF3_18692474_ChIP-Seq_MESCs_Mouse1.29747796
56HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.26453848
57ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.26031411
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25342721
59NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.25206241
60E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.25060711
61KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22785880
62ETS1_20019798_ChIP-Seq_JURKAT_Human1.22303871
63ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.20579888
64ELK1_19687146_ChIP-ChIP_HELA_Human1.20244072
65KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.19976596
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.18981741
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18952189
68CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.18896938
69PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.18288918
70EST1_17652178_ChIP-ChIP_JURKAT_Human1.18281104
71CIITA_25753668_ChIP-Seq_RAJI_Human1.18187955
72CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.16847279
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16093231
74KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.15661768
75FOXP3_21729870_ChIP-Seq_TREG_Human1.15645122
76NANOG_21062744_ChIP-ChIP_HESCs_Human1.15644019
77HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10701070
78FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10163634
79KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09020992
80E2F1_18555785_ChIP-Seq_MESCs_Mouse1.08806293
81POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06371511
82NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.02846360
83RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02693572
84ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02160027
85POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.02116475
86VDR_23849224_ChIP-Seq_CD4+_Human1.01695380
87ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01491946
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00455323
89* DCP1A_22483619_ChIP-Seq_HELA_Human0.97526580
90SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.97493753
91FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.96509944
92VDR_21846776_ChIP-Seq_THP-1_Human0.95730281
93TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.93755974
94SOX2_18692474_ChIP-Seq_MESCs_Mouse0.93259206
95PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91471743
96PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91114658
97TFEB_21752829_ChIP-Seq_HELA_Human0.90505150
98GABP_19822575_ChIP-Seq_HepG2_Human0.87522031
99MYC_18940864_ChIP-ChIP_HL60_Human0.87196258
100ZNF263_19887448_ChIP-Seq_K562_Human0.86299654

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.31446638
2MP0003693_abnormal_embryo_hatching3.96480669
3MP0003111_abnormal_nucleus_morphology3.55856428
4MP0004957_abnormal_blastocyst_morpholog3.47372016
5MP0010094_abnormal_chromosome_stability3.18883658
6MP0008877_abnormal_DNA_methylation2.94456239
7MP0003077_abnormal_cell_cycle2.94215904
8MP0008058_abnormal_DNA_repair2.89742784
9MP0003890_abnormal_embryonic-extraembry2.76532389
10MP0008932_abnormal_embryonic_tissue2.60751937
11MP0003941_abnormal_skin_development2.48685291
12MP0002254_reproductive_system_inflammat2.38791881
13MP0001730_embryonic_growth_arrest2.38477986
14MP0006292_abnormal_olfactory_placode2.21353047
15MP0000350_abnormal_cell_proliferation2.12545495
16MP0010352_gastrointestinal_tract_polyps2.09114085
17MP0009672_abnormal_birth_weight2.08888896
18MP0010307_abnormal_tumor_latency2.07991674
19MP0004185_abnormal_adipocyte_glucose1.97027984
20MP0001293_anophthalmia1.87776120
21MP0005380_embryogenesis_phenotype1.87207390
22MP0001672_abnormal_embryogenesis/_devel1.87207390
23MP0001188_hyperpigmentation1.87097697
24MP0008007_abnormal_cellular_replicative1.80806576
25MP0003984_embryonic_growth_retardation1.72626024
26MP0002085_abnormal_embryonic_tissue1.72492666
27MP0002084_abnormal_developmental_patter1.69626669
28MP0003567_abnormal_fetal_cardiomyocyte1.67472478
29MP0002088_abnormal_embryonic_growth/wei1.66912101
30MP0002697_abnormal_eye_size1.65705596
31MP0009379_abnormal_foot_pigmentation1.64483160
32MP0004197_abnormal_fetal_growth/weight/1.63009993
33MP0001697_abnormal_embryo_size1.59236518
34MP0003937_abnormal_limbs/digits/tail_de1.55803455
35MP0009703_decreased_birth_body1.49045709
36MP0000537_abnormal_urethra_morphology1.47396341
37MP0002009_preneoplasia1.46886622
38MP0001286_abnormal_eye_development1.46417439
39MP0004808_abnormal_hematopoietic_stem1.43307884
40MP0004233_abnormal_muscle_weight1.41231992
41MP0002080_prenatal_lethality1.41153426
42MP0002396_abnormal_hematopoietic_system1.35194350
43MP0005076_abnormal_cell_differentiation1.33067544
44MP0010030_abnormal_orbit_morphology1.29699826
45MP0002086_abnormal_extraembryonic_tissu1.29575530
46MP0003787_abnormal_imprinting1.27817271
47MP0000313_abnormal_cell_death1.26108660
48MP0000428_abnormal_craniofacial_morphol1.25997447
49MP0002796_impaired_skin_barrier1.24020085
50MP0003705_abnormal_hypodermis_morpholog1.20969298
51MP0003123_paternal_imprinting1.20951538
52MP0009053_abnormal_anal_canal1.20606212
53MP0003861_abnormal_nervous_system1.19459375
54MP0000432_abnormal_head_morphology1.14083765
55MP0002092_abnormal_eye_morphology1.13608102
56MP0000049_abnormal_middle_ear1.07505813
57MP0002111_abnormal_tail_morphology1.01453377
58MP0003718_maternal_effect0.99553984
59MP0002234_abnormal_pharynx_morphology0.98811050
60MP0000703_abnormal_thymus_morphology0.97411903
61MP0000579_abnormal_nail_morphology0.95888512
62MP0000490_abnormal_crypts_of0.95186810
63MP0004264_abnormal_extraembryonic_tissu0.94896446
64MP0002233_abnormal_nose_morphology0.94565168
65MP0003935_abnormal_craniofacial_develop0.92935692
66MP0002249_abnormal_larynx_morphology0.91905031
67MP0002210_abnormal_sex_determination0.91444694
68MP0004133_heterotaxia0.91113935
69MP0003119_abnormal_digestive_system0.91001691
70MP0003646_muscle_fatigue0.87788819
71MP0003136_yellow_coat_color0.82955329
72MP0003121_genomic_imprinting0.82882628
73MP0009250_abnormal_appendicular_skeleto0.79734010
74MP0005501_abnormal_skin_physiology0.79204171
75MP0002081_perinatal_lethality0.77782495
76MP0003221_abnormal_cardiomyocyte_apopto0.77498170
77MP0003786_premature_aging0.76602661
78MP0001929_abnormal_gametogenesis0.74996429
79MP0001145_abnormal_male_reproductive0.74882855
80MP0001340_abnormal_eyelid_morphology0.73546740
81MP0002177_abnormal_outer_ear0.73052403
82MP0003942_abnormal_urinary_system0.72847117
83MP0002019_abnormal_tumor_incidence0.72713993
84MP0005621_abnormal_cell_physiology0.72475910
85MP0005666_abnormal_adipose_tissue0.70928389
86MP0010630_abnormal_cardiac_muscle0.70487269
87MP0002163_abnormal_gland_morphology0.69581303
88MP0003755_abnormal_palate_morphology0.69535291
89MP0003115_abnormal_respiratory_system0.68569074
90MP0001346_abnormal_lacrimal_gland0.68466887
91MP0005409_darkened_coat_color0.68224144
92MP0003315_abnormal_perineum_morphology0.65775877
93MP0001299_abnormal_eye_distance/0.65694621
94MP0000678_abnormal_parathyroid_gland0.65057960
95MP0003943_abnormal_hepatobiliary_system0.64907715
96MP0009278_abnormal_bone_marrow0.64621954
97MP0010234_abnormal_vibrissa_follicle0.63579719
98MP0002114_abnormal_axial_skeleton0.63015528
99MP0005384_cellular_phenotype0.62089952
100MP0000653_abnormal_sex_gland0.60927244

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.94979907
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.16757517
3Chromsome breakage (HP:0040012)3.97921293
4Neonatal hypoglycemia (HP:0001998)3.73327865
5Reticulocytopenia (HP:0001896)3.52813640
6Nephroblastoma (Wilms tumor) (HP:0002667)3.37269550
7Neoplasm of the adrenal cortex (HP:0100641)3.33702243
8Hepatoblastoma (HP:0002884)3.30254284
9Colon cancer (HP:0003003)3.27343447
10Embryonal renal neoplasm (HP:0011794)3.10176783
11Multiple enchondromatosis (HP:0005701)3.05027708
12Lip pit (HP:0100267)3.01697248
13Rhabdomyosarcoma (HP:0002859)2.87164473
14Aplasia/Hypoplasia of the sternum (HP:0006714)2.57350416
15Abnormal number of incisors (HP:0011064)2.54903394
16Abnormality of the fingertips (HP:0001211)2.49669714
17Abnormality of the columella (HP:0009929)2.48281720
18Dysmetric saccades (HP:0000641)2.47149984
19Ectopic kidney (HP:0000086)2.39696065
20Cortical dysplasia (HP:0002539)2.37431676
21Depressed nasal tip (HP:0000437)2.37056452
22Selective tooth agenesis (HP:0001592)2.31469489
23Increased nuchal translucency (HP:0010880)2.25091495
24Long eyelashes (HP:0000527)2.24016762
25Long palpebral fissure (HP:0000637)2.23639202
26High anterior hairline (HP:0009890)2.23534827
27Septo-optic dysplasia (HP:0100842)2.20787593
28Abnormality of the labia minora (HP:0012880)2.20677153
29Abnormality of DNA repair (HP:0003254)2.20082546
30Abnormality of chromosome stability (HP:0003220)2.20022792
31Acute lymphatic leukemia (HP:0006721)2.19818001
32Progressive muscle weakness (HP:0003323)2.17866463
33Facial cleft (HP:0002006)2.16269892
34Missing ribs (HP:0000921)2.14645074
35Curly hair (HP:0002212)2.11008195
36Volvulus (HP:0002580)2.09592904
37Progressive external ophthalmoplegia (HP:0000590)2.09585024
38Abdominal situs inversus (HP:0003363)2.07823066
39Abnormality of abdominal situs (HP:0011620)2.07823066
40Duplication of thumb phalanx (HP:0009942)2.06281591
41Protruding tongue (HP:0010808)2.04650710
42Abnormal hair whorl (HP:0010721)2.03528408
43Embryonal neoplasm (HP:0002898)2.03404588
44Deep palmar crease (HP:0006191)2.03290401
45Medulloblastoma (HP:0002885)2.00690871
462-3 toe syndactyly (HP:0004691)2.00117014
47Preauricular skin tag (HP:0000384)1.99981096
48Neoplasm of striated muscle (HP:0009728)1.99443493
49Homocystinuria (HP:0002156)1.98385257
50Abnormality of homocysteine metabolism (HP:0010919)1.98385257
5111 pairs of ribs (HP:0000878)1.98382084
52Atresia of the external auditory canal (HP:0000413)1.97770498
53Deep philtrum (HP:0002002)1.96411294
54Gastrointestinal carcinoma (HP:0002672)1.94653699
55Malignant gastrointestinal tract tumors (HP:0006749)1.94653699
56Aplasia/Hypoplasia of the uvula (HP:0010293)1.92559076
57Meckel diverticulum (HP:0002245)1.92008312
58Abnormal lung lobation (HP:0002101)1.91877727
59Sensory axonal neuropathy (HP:0003390)1.91016850
60Abnormality of cells of the erythroid lineage (HP:0012130)1.90990108
61Aplasia/Hypoplasia of the sacrum (HP:0008517)1.89529373
62Impulsivity (HP:0100710)1.88353108
63Absent radius (HP:0003974)1.87787759
64Abnormality of the septum pellucidum (HP:0007375)1.86982564
65Poikiloderma (HP:0001029)1.86540081
66Long foot (HP:0001833)1.84202213
67Myelodysplasia (HP:0002863)1.83962188
68Abnormality of cochlea (HP:0000375)1.82173699
69Cafe-au-lait spot (HP:0000957)1.81403005
70Capillary hemangiomas (HP:0005306)1.79853895
71Breast aplasia (HP:0100783)1.79574575
72Broad thumb (HP:0011304)1.78205164
73Abnormality of the renal collecting system (HP:0004742)1.78191848
74Obsessive-compulsive behavior (HP:0000722)1.78142576
75Microvesicular hepatic steatosis (HP:0001414)1.78114615
76Duplicated collecting system (HP:0000081)1.78050024
77Abnormality of the ileum (HP:0001549)1.77824481
78Abnormality of the preputium (HP:0100587)1.77671511
79Dysphonia (HP:0001618)1.76494803
80Spastic diplegia (HP:0001264)1.75105742
81Abnormality of the salivary glands (HP:0010286)1.74755919
82Acute myeloid leukemia (HP:0004808)1.73762442
83Stenosis of the external auditory canal (HP:0000402)1.72933634
84Bilateral microphthalmos (HP:0007633)1.71006825
85Skin tags (HP:0010609)1.70542516
86Septate vagina (HP:0001153)1.68711448
87Esophageal atresia (HP:0002032)1.68538768
88Proximal placement of thumb (HP:0009623)1.68060539
89Partial agenesis of the corpus callosum (HP:0001338)1.67731435
90Coarctation of aorta (HP:0001680)1.67109148
91Absent thumb (HP:0009777)1.67021586
92Choanal stenosis (HP:0000452)1.65296267
93Cutaneous syndactyly (HP:0012725)1.65111995
94Macrocytic anemia (HP:0001972)1.64825291
95Cubitus valgus (HP:0002967)1.64743066
96Aplasia/Hypoplasia of the breasts (HP:0010311)1.63918615
97Pallor (HP:0000980)1.63731167
98Uterine leiomyosarcoma (HP:0002891)1.63400031
99Leiomyosarcoma (HP:0100243)1.63400031
100Aplasia involving forearm bones (HP:0009822)1.63295762

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.47405140
2CDK123.46579129
3CAMK1D3.25919061
4BRD43.02036269
5CAMK1G2.91925450
6TTK2.66284126
7MKNK22.66107656
8BRSK22.52612505
9MAP3K102.43142670
10SMG12.34805237
11TSSK62.33499188
12SRPK12.20964117
13BUB12.18754631
14WEE12.13070871
15CDK192.12348948
16TAF12.07025042
17EEF2K2.05997022
18TLK12.00853407
19PNCK1.96102128
20MAP3K91.93098764
21MKNK11.82446896
22PLK41.77403523
23DYRK31.71585048
24CHEK21.69658879
25ZAK1.55739177
26ATR1.49314316
27ERBB41.49134473
28PLK11.45766100
29PIM11.33574827
30PLK31.32339155
31EIF2AK31.25170188
32CHEK11.23929280
33BRAF1.16741351
34BRSK11.06556219
35TYRO31.05925380
36ATM1.04777357
37CDK71.02394604
38PRPF4B1.00846170
39ICK0.96511192
40STK30.96104247
41STK240.95251309
42PIK3CA0.94286908
43CDK20.90472573
44MTOR0.85964396
45SGK30.85139430
46RPS6KB20.84724301
47LATS10.84578481
48SGK20.83845994
49RAF10.82342053
50AURKA0.81393456
51ALK0.81120663
52TNIK0.80466328
53STK160.79753123
54KSR20.79133525
55STK40.74824657
56AURKB0.74081047
57SCYL20.73504441
58CDK10.73143497
59PASK0.73122219
60FGFR10.70057202
61WNK10.68447676
62IRAK10.68353589
63DYRK20.67645591
64CDK40.67574281
65SGK2230.65463791
66SGK4940.65463791
67LATS20.65416380
68STK110.64715594
69DMPK0.62682768
70IRAK20.61704423
71YES10.60043000
72MAP3K80.59992274
73MELK0.56090216
74PRKDC0.55729061
75VRK10.55346269
76CDK60.53197471
77DYRK1A0.52972135
78PDGFRB0.52682900
79RPS6KA10.52034080
80NLK0.51509194
81GSK3B0.49385604
82CAMKK20.49377930
83CSNK1E0.48787351
84NEK20.46488200
85RPS6KB10.45670113
86EIF2AK20.45298340
87OXSR10.44785531
88BMX0.44080797
89MARK20.44004769
90CSNK1G10.42017900
91MAPK140.41749059
92CDK30.41484701
93AKT10.39756254
94NUAK10.36021386
95PBK0.34498496
96KSR10.33521060
97MAPK100.33240837
98SGK10.32107789
99CSNK1D0.32023895
100PTK20.30990287

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.35238482
2Cell cycle_Homo sapiens_hsa041103.07273959
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.86941717
4Spliceosome_Homo sapiens_hsa030402.53067568
5RNA transport_Homo sapiens_hsa030132.49479255
6Mismatch repair_Homo sapiens_hsa034302.46173607
7mRNA surveillance pathway_Homo sapiens_hsa030152.30908986
8Non-homologous end-joining_Homo sapiens_hsa034502.23574271
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.13929281
10Homologous recombination_Homo sapiens_hsa034402.04511279
11Thyroid cancer_Homo sapiens_hsa052161.92825100
12Base excision repair_Homo sapiens_hsa034101.92677173
13Fanconi anemia pathway_Homo sapiens_hsa034601.88706584
14Ribosome_Homo sapiens_hsa030101.87767589
15p53 signaling pathway_Homo sapiens_hsa041151.85215476
16RNA polymerase_Homo sapiens_hsa030201.76455798
17Selenocompound metabolism_Homo sapiens_hsa004501.76398677
18Chronic myeloid leukemia_Homo sapiens_hsa052201.73742629
19MicroRNAs in cancer_Homo sapiens_hsa052061.66023098
20Prostate cancer_Homo sapiens_hsa052151.53841370
21Colorectal cancer_Homo sapiens_hsa052101.53231760
22Endometrial cancer_Homo sapiens_hsa052131.51127159
23Nucleotide excision repair_Homo sapiens_hsa034201.49292460
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.43976499
25Non-small cell lung cancer_Homo sapiens_hsa052231.43499587
26Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.43400684
27Vitamin B6 metabolism_Homo sapiens_hsa007501.41534890
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.40395814
29RNA degradation_Homo sapiens_hsa030181.39567505
30Bladder cancer_Homo sapiens_hsa052191.36522607
31Basal transcription factors_Homo sapiens_hsa030221.34474330
32One carbon pool by folate_Homo sapiens_hsa006701.33462495
33Viral carcinogenesis_Homo sapiens_hsa052031.32829782
34Adherens junction_Homo sapiens_hsa045201.25158814
35Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.24193610
36Notch signaling pathway_Homo sapiens_hsa043301.23832303
37Acute myeloid leukemia_Homo sapiens_hsa052211.23729768
38Alcoholism_Homo sapiens_hsa050341.22531979
39Lysine degradation_Homo sapiens_hsa003101.16348820
40FoxO signaling pathway_Homo sapiens_hsa040681.16222588
41ErbB signaling pathway_Homo sapiens_hsa040121.14196663
42Oocyte meiosis_Homo sapiens_hsa041141.10671655
43Renal cell carcinoma_Homo sapiens_hsa052111.10583298
44Central carbon metabolism in cancer_Homo sapiens_hsa052301.09539610
45Pancreatic cancer_Homo sapiens_hsa052121.07044280
46B cell receptor signaling pathway_Homo sapiens_hsa046621.04073725
47Melanoma_Homo sapiens_hsa052181.01684923
48Longevity regulating pathway - mammal_Homo sapiens_hsa042111.01003082
49Glioma_Homo sapiens_hsa052140.99628766
50Systemic lupus erythematosus_Homo sapiens_hsa053220.96015450
51Thyroid hormone signaling pathway_Homo sapiens_hsa049190.95434602
52Hippo signaling pathway_Homo sapiens_hsa043900.93919884
53TGF-beta signaling pathway_Homo sapiens_hsa043500.93187349
54Pyrimidine metabolism_Homo sapiens_hsa002400.92284596
55Basal cell carcinoma_Homo sapiens_hsa052170.89198062
56mTOR signaling pathway_Homo sapiens_hsa041500.88590878
57Wnt signaling pathway_Homo sapiens_hsa043100.85720905
58Epstein-Barr virus infection_Homo sapiens_hsa051690.85660495
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.84101508
60Hepatitis B_Homo sapiens_hsa051610.84008516
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.82665469
62Prolactin signaling pathway_Homo sapiens_hsa049170.78404931
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77502353
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74536602
65VEGF signaling pathway_Homo sapiens_hsa043700.73287197
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72262980
67HTLV-I infection_Homo sapiens_hsa051660.71001330
68Apoptosis_Homo sapiens_hsa042100.70329620
69T cell receptor signaling pathway_Homo sapiens_hsa046600.69790795
70Insulin signaling pathway_Homo sapiens_hsa049100.68030529
71Proteoglycans in cancer_Homo sapiens_hsa052050.67194901
72Measles_Homo sapiens_hsa051620.64043197
73Small cell lung cancer_Homo sapiens_hsa052220.62450403
74Herpes simplex infection_Homo sapiens_hsa051680.60475051
75Pathways in cancer_Homo sapiens_hsa052000.59474872
76Choline metabolism in cancer_Homo sapiens_hsa052310.57934359
77MAPK signaling pathway_Homo sapiens_hsa040100.57401045
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55480800
79Dorso-ventral axis formation_Homo sapiens_hsa043200.54858983
80Type II diabetes mellitus_Homo sapiens_hsa049300.54561836
81Long-term potentiation_Homo sapiens_hsa047200.53790347
82Inositol phosphate metabolism_Homo sapiens_hsa005620.52698523
83Estrogen signaling pathway_Homo sapiens_hsa049150.52125656
84AMPK signaling pathway_Homo sapiens_hsa041520.51665209
85Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50501911
86Hepatitis C_Homo sapiens_hsa051600.49431693
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48597463
88Tight junction_Homo sapiens_hsa045300.44287530
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43504654
90Hedgehog signaling pathway_Homo sapiens_hsa043400.42853355
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41628385
92Purine metabolism_Homo sapiens_hsa002300.40935904
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.39814775
94Axon guidance_Homo sapiens_hsa043600.37700624
95Steroid biosynthesis_Homo sapiens_hsa001000.35846948
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35253179
97Pentose phosphate pathway_Homo sapiens_hsa000300.34700614
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34474210
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33863732
100Long-term depression_Homo sapiens_hsa047300.31764881

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