ZNF402P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuronal stem cell maintenance (GO:0097150)7.00144313
2nephron tubule morphogenesis (GO:0072078)6.93736744
3nephron epithelium morphogenesis (GO:0072088)6.93736744
4protein localization to cilium (GO:0061512)6.57714718
5forebrain neuron differentiation (GO:0021879)5.59037440
6glomerular filtration (GO:0003094)5.55818426
7regulation of timing of cell differentiation (GO:0048505)5.17295480
8renal tubule morphogenesis (GO:0061333)5.05754088
9neuron fate determination (GO:0048664)5.01374943
10renal filtration (GO:0097205)4.89123259
11regulation of development, heterochronic (GO:0040034)4.73794448
12glomerular basement membrane development (GO:0032836)4.70877436
13behavioral response to nicotine (GO:0035095)4.69759045
14negative regulation of epidermal cell differentiation (GO:0045605)4.68284744
15spermatid nucleus differentiation (GO:0007289)4.64708071
16positive regulation of Notch signaling pathway (GO:0045747)4.59237488
17negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)4.54148183
18adaptation of signaling pathway (GO:0023058)4.39654723
19cardiac right ventricle morphogenesis (GO:0003215)4.08502490
20dermatan sulfate biosynthetic process (GO:0030208)4.05163266
21positive regulation of phosphoprotein phosphatase activity (GO:0032516)4.04960621
22negative regulation of oligodendrocyte differentiation (GO:0048715)4.01534814
23neuron cell-cell adhesion (GO:0007158)3.94209983
24negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.92495482
25detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.91441856
26neural tube formation (GO:0001841)3.81621066
27cell morphogenesis involved in neuron differentiation (GO:0048667)3.74431126
28negative regulation of mast cell activation (GO:0033004)3.66882634
29acrosome assembly (GO:0001675)3.60778972
30protein polyglutamylation (GO:0018095)3.59008839
31nonmotile primary cilium assembly (GO:0035058)3.58779346
32dermatan sulfate metabolic process (GO:0030205)3.56688239
33DNA damage response, detection of DNA damage (GO:0042769)3.55919266
34negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.48783504
35cerebral cortex neuron differentiation (GO:0021895)3.46223029
36intraciliary transport (GO:0042073)3.45882009
37regulation of action potential (GO:0098900)3.45299866
38glycosphingolipid biosynthetic process (GO:0006688)3.40335915
39negative regulation of epidermis development (GO:0045683)3.39372922
40tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.38723185
41RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.38723185
42kidney morphogenesis (GO:0060993)3.37636485
43positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.33990269
44retinal ganglion cell axon guidance (GO:0031290)3.28524933
45negative regulation of smooth muscle cell differentiation (GO:0051151)3.26468547
46tongue development (GO:0043586)3.24110330
47cilium morphogenesis (GO:0060271)3.18080488
48positive regulation of uterine smooth muscle contraction (GO:0070474)3.13454501
49axonal fasciculation (GO:0007413)3.11156895
50epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.10952831
51fucose catabolic process (GO:0019317)3.06363392
52L-fucose metabolic process (GO:0042354)3.06363392
53L-fucose catabolic process (GO:0042355)3.06363392
54regulation of organ formation (GO:0003156)3.06292636
55limb bud formation (GO:0060174)3.04408684
56tryptophan catabolic process (GO:0006569)3.04245053
57indole-containing compound catabolic process (GO:0042436)3.04245053
58indolalkylamine catabolic process (GO:0046218)3.04245053
59radial glial cell differentiation (GO:0060019)3.04131977
60kynurenine metabolic process (GO:0070189)3.00779301
61neuronal action potential (GO:0019228)2.99781983
62regulation of hexokinase activity (GO:1903299)2.98092170
63regulation of glucokinase activity (GO:0033131)2.98092170
64negative regulation of glial cell proliferation (GO:0060253)2.96735666
65regulation of oligodendrocyte differentiation (GO:0048713)2.95766831
66synaptic transmission, cholinergic (GO:0007271)2.95620195
67regulation of secondary heart field cardioblast proliferation (GO:0003266)2.95248220
68regulation of cardioblast proliferation (GO:0003264)2.95248220
69innervation (GO:0060384)2.94713369
70axon ensheathment in central nervous system (GO:0032291)2.87853388
71central nervous system myelination (GO:0022010)2.87853388
72gamma-aminobutyric acid signaling pathway (GO:0007214)2.87327344
73axoneme assembly (GO:0035082)2.86992010
74relaxation of smooth muscle (GO:0044557)2.86269641
75negative regulation of cell cycle arrest (GO:0071157)2.84534164
76positive regulation of mast cell activation involved in immune response (GO:0033008)2.83830724
77positive regulation of mast cell degranulation (GO:0043306)2.83830724
78regulation of gene silencing by RNA (GO:0060966)2.83666394
79regulation of posttranscriptional gene silencing (GO:0060147)2.83666394
80regulation of gene silencing by miRNA (GO:0060964)2.83666394
81ventricular system development (GO:0021591)2.83538438
82negative regulation of glial cell differentiation (GO:0045686)2.83416810
83metallo-sulfur cluster assembly (GO:0031163)2.82839260
84iron-sulfur cluster assembly (GO:0016226)2.82839260
85protein localization to synapse (GO:0035418)2.80018946
86presynaptic membrane assembly (GO:0097105)2.79306478
87membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.78079796
88short-term memory (GO:0007614)2.77543736
89platelet dense granule organization (GO:0060155)2.75373142
90ganglioside metabolic process (GO:0001573)2.74535653
91renal absorption (GO:0070293)2.74484376
92neuron recognition (GO:0008038)2.73423661
93cell-cell signaling involved in cell fate commitment (GO:0045168)2.72589183
94regulation of Notch signaling pathway (GO:0008593)2.72097661
95telencephalon development (GO:0021537)2.71220604
96epithelial cilium movement (GO:0003351)2.69064486
97positive regulation of glial cell differentiation (GO:0045687)2.68094876
98pyrimidine nucleobase catabolic process (GO:0006208)2.67613510
99piRNA metabolic process (GO:0034587)2.67255921
100sympathetic nervous system development (GO:0048485)2.66815210

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.76539712
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.75237311
3EZH2_22144423_ChIP-Seq_EOC_Human3.73098521
4ZNF274_21170338_ChIP-Seq_K562_Hela3.30463566
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.24561427
6GBX2_23144817_ChIP-Seq_PC3_Human3.01499477
7TAF15_26573619_Chip-Seq_HEK293_Human2.86871498
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.71327850
9CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.38134468
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.32290484
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.27355083
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23833677
13EWS_26573619_Chip-Seq_HEK293_Human2.15764111
14RNF2_27304074_Chip-Seq_NSC_Mouse2.13920636
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.12389500
16ER_23166858_ChIP-Seq_MCF-7_Human2.11417912
17P300_19829295_ChIP-Seq_ESCs_Human2.04501007
18IGF1R_20145208_ChIP-Seq_DFB_Human2.04269855
19CBX2_27304074_Chip-Seq_ESCs_Mouse2.03457465
20FUS_26573619_Chip-Seq_HEK293_Human1.98756787
21JARID2_20064375_ChIP-Seq_MESCs_Mouse1.98287735
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.94553608
23TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89569818
24POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.89569818
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.89409646
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89146399
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.88332951
28POU5F1_16153702_ChIP-ChIP_HESCs_Human1.81506584
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73214686
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.71482789
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.69674414
32AR_25329375_ChIP-Seq_VCAP_Human1.69268568
33REST_21632747_ChIP-Seq_MESCs_Mouse1.68590806
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.65017526
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.62373852
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.59851213
37TOP2B_26459242_ChIP-Seq_MCF-7_Human1.54946787
38IRF1_19129219_ChIP-ChIP_H3396_Human1.54114820
39SMAD3_21741376_ChIP-Seq_EPCs_Human1.52528959
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.49627278
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49292385
42KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.49069238
43NR3C1_21868756_ChIP-Seq_MCF10A_Human1.48044976
44EED_16625203_ChIP-ChIP_MESCs_Mouse1.47955542
45RNF2_18974828_ChIP-Seq_MESCs_Mouse1.47744774
46EZH2_18974828_ChIP-Seq_MESCs_Mouse1.47744774
47CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47202562
48SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.46925146
49SMAD4_21799915_ChIP-Seq_A2780_Human1.46919890
50JARID2_20075857_ChIP-Seq_MESCs_Mouse1.46198031
51SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44601933
52BCAT_22108803_ChIP-Seq_LS180_Human1.42683103
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41496995
54EZH2_27294783_Chip-Seq_ESCs_Mouse1.41416343
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40094471
56FLI1_21867929_ChIP-Seq_TH2_Mouse1.39037109
57ETV2_25802403_ChIP-Seq_MESCs_Mouse1.37997956
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37270457
59TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.36937077
60SOX2_19829295_ChIP-Seq_ESCs_Human1.36593302
61NANOG_19829295_ChIP-Seq_ESCs_Human1.36593302
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35688142
63CBP_20019798_ChIP-Seq_JUKART_Human1.35688142
64STAT3_23295773_ChIP-Seq_U87_Human1.35182294
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34464100
66TAL1_26923725_Chip-Seq_HPCs_Mouse1.30852722
67PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29812909
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27735031
69AR_21572438_ChIP-Seq_LNCaP_Human1.25413813
70ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.24837372
71RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.24831307
72RNF2_27304074_Chip-Seq_ESCs_Mouse1.23897448
73TCF4_23295773_ChIP-Seq_U87_Human1.22073867
74TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21747441
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21253976
76SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.20207999
77LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17172545
78RUNX2_22187159_ChIP-Seq_PCA_Human1.17101544
79TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16665689
80SUZ12_27294783_Chip-Seq_ESCs_Mouse1.15669839
81KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12697848
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.12627464
83SOX9_26525672_Chip-Seq_HEART_Mouse1.11224582
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10402271
85PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08734263
86HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.08633042
87KDM2B_26808549_Chip-Seq_REH_Human1.07997653
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06321078
89SMAD4_21741376_ChIP-Seq_EPCs_Human1.04293960
90NANOG_18555785_Chip-Seq_ESCs_Mouse1.04234932
91JUN_21703547_ChIP-Seq_K562_Human1.04182533
92MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03927742
93TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.03029043
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02288083
95P53_22387025_ChIP-Seq_ESCs_Mouse1.02247883
96STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01786360
97SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.00091904
98LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99916696
99RXR_22108803_ChIP-Seq_LS180_Human0.99556901
100SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.99416001

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.37313918
2MP0002653_abnormal_ependyma_morphology3.45651974
3MP0002102_abnormal_ear_morphology3.20233175
4MP0008789_abnormal_olfactory_epithelium3.15144411
5MP0003880_abnormal_central_pattern3.12478007
6MP0004133_heterotaxia2.79455001
7MP0008877_abnormal_DNA_methylation2.66279758
8MP0005499_abnormal_olfactory_system2.61978764
9MP0005394_taste/olfaction_phenotype2.61978764
10MP0008995_early_reproductive_senescence2.56731374
11MP0002822_catalepsy2.54390363
12MP0003195_calcinosis2.45372268
13MP0002751_abnormal_autonomic_nervous2.29286551
14MP0000467_abnormal_esophagus_morphology2.28667162
15MP0000569_abnormal_digit_pigmentation2.22026843
16MP0006292_abnormal_olfactory_placode2.20254133
17MP0001984_abnormal_olfaction2.18570229
18MP0002928_abnormal_bile_duct2.18434857
19MP0004742_abnormal_vestibular_system1.99813394
20MP0002234_abnormal_pharynx_morphology1.94913214
21MP0000631_abnormal_neuroendocrine_gland1.86739675
22MP0006072_abnormal_retinal_apoptosis1.86204131
23MP0003890_abnormal_embryonic-extraembry1.82673094
24MP0005551_abnormal_eye_electrophysiolog1.76698445
25MP0005084_abnormal_gallbladder_morpholo1.76678134
26MP0002736_abnormal_nociception_after1.71173466
27MP0009053_abnormal_anal_canal1.70042245
28MP0003011_delayed_dark_adaptation1.68728837
29MP0003646_muscle_fatigue1.67168687
30MP0003122_maternal_imprinting1.66930070
31MP0008961_abnormal_basal_metabolism1.65086450
32MP0002272_abnormal_nervous_system1.63979595
33MP0008875_abnormal_xenobiotic_pharmacok1.54272908
34MP0001485_abnormal_pinna_reflex1.54045387
35MP0000778_abnormal_nervous_system1.53464594
36MP0005423_abnormal_somatic_nervous1.53006312
37MP0001293_anophthalmia1.50590081
38MP0006276_abnormal_autonomic_nervous1.46356212
39MP0000026_abnormal_inner_ear1.43278457
40MP0000383_abnormal_hair_follicle1.42727656
41MP0002876_abnormal_thyroid_physiology1.42641511
42MP0004043_abnormal_pH_regulation1.42420843
43MP0005195_abnormal_posterior_eye1.41552966
44MP0009379_abnormal_foot_pigmentation1.40167686
45MP0005646_abnormal_pituitary_gland1.37325929
46MP0000955_abnormal_spinal_cord1.33132453
47MP0002282_abnormal_trachea_morphology1.32908349
48MP0005253_abnormal_eye_physiology1.32745012
49MP0001286_abnormal_eye_development1.30831685
50MP0002734_abnormal_mechanical_nocicepti1.29879413
51MP0000372_irregular_coat_pigmentation1.29070137
52MP0001970_abnormal_pain_threshold1.28442200
53MP0009046_muscle_twitch1.25847109
54MP0009745_abnormal_behavioral_response1.25827929
55MP0002064_seizures1.24971921
56MP0002752_abnormal_somatic_nervous1.18850267
57MP0004142_abnormal_muscle_tone1.17460330
58MP0003119_abnormal_digestive_system1.16350974
59MP0004147_increased_porphyrin_level1.12890598
60MP0000534_abnormal_ureter_morphology1.10452821
61MP0002733_abnormal_thermal_nociception1.09278263
62MP0005645_abnormal_hypothalamus_physiol1.04962587
63MP0002277_abnormal_respiratory_mucosa1.02952875
64MP0003635_abnormal_synaptic_transmissio1.02139055
65MP0002638_abnormal_pupillary_reflex1.01214296
66MP0001968_abnormal_touch/_nociception1.01147162
67MP0002572_abnormal_emotion/affect_behav0.97854212
68MP0005310_abnormal_salivary_gland0.95066328
69MP0002735_abnormal_chemical_nociception0.94796754
70MP0000049_abnormal_middle_ear0.94640525
71MP0002882_abnormal_neuron_morphology0.92880499
72MP0006035_abnormal_mitochondrial_morpho0.91156814
73MP0003938_abnormal_ear_development0.90701771
74MP0005174_abnormal_tail_pigmentation0.89028008
75MP0004885_abnormal_endolymph0.88782677
76MP0001963_abnormal_hearing_physiology0.88683624
77MP0001324_abnormal_eye_pigmentation0.86563580
78MP0005075_abnormal_melanosome_morpholog0.85458651
79MP0003861_abnormal_nervous_system0.85351114
80MP0008872_abnormal_physiological_respon0.84669208
81MP0002697_abnormal_eye_size0.84278066
82MP0009765_abnormal_xenobiotic_induced0.83507722
83MP0010386_abnormal_urinary_bladder0.82150820
84MP0005647_abnormal_sex_gland0.79243451
85MP0002152_abnormal_brain_morphology0.78927332
86MP0003806_abnormal_nucleotide_metabolis0.78317441
87MP0002184_abnormal_innervation0.78207786
88MP0003283_abnormal_digestive_organ0.76831586
89MP0005391_vision/eye_phenotype0.76794998
90MP0003121_genomic_imprinting0.76776351
91MP0002938_white_spotting0.76589159
92MP0001486_abnormal_startle_reflex0.76135901
93MP0002063_abnormal_learning/memory/cond0.75107109
94MP0002557_abnormal_social/conspecific_i0.72921637
95MP0002095_abnormal_skin_pigmentation0.71508028
96MP0003879_abnormal_hair_cell0.69962901
97MP0002932_abnormal_joint_morphology0.67442980
98MP0003698_abnormal_male_reproductive0.66353347
99MP0004085_abnormal_heartbeat0.65534226
100MP0004215_abnormal_myocardial_fiber0.64778493

Predicted human phenotypes

RankGene SetZ-score
1Molar tooth sign on MRI (HP:0002419)3.78469882
2Abnormality of midbrain morphology (HP:0002418)3.78469882
3Pancreatic fibrosis (HP:0100732)3.39308733
4Abnormality of alanine metabolism (HP:0010916)3.38985819
5Hyperalaninemia (HP:0003348)3.38985819
6Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.38985819
7Thyroid-stimulating hormone excess (HP:0002925)3.27155892
8Fibular aplasia (HP:0002990)3.20557952
9Pancreatic cysts (HP:0001737)3.14334781
10Chronic hepatic failure (HP:0100626)3.08468723
11Type II lissencephaly (HP:0007260)3.04331278
12Adactyly (HP:0009776)3.02987755
13Concave nail (HP:0001598)2.99983766
14Gonadotropin excess (HP:0000837)2.97868398
15Confusion (HP:0001289)2.94591022
16Abolished electroretinogram (ERG) (HP:0000550)2.91067120
17Septo-optic dysplasia (HP:0100842)2.86021542
18Limb dystonia (HP:0002451)2.77366162
19Mutism (HP:0002300)2.71630207
20Inability to walk (HP:0002540)2.71279020
21Nephronophthisis (HP:0000090)2.68227335
22Retinal dysplasia (HP:0007973)2.67098222
23Decreased central vision (HP:0007663)2.64585837
24Progressive inability to walk (HP:0002505)2.59171783
25Partial agenesis of the corpus callosum (HP:0001338)2.58912805
26Abnormality of the fovea (HP:0000493)2.58875665
27True hermaphroditism (HP:0010459)2.53538998
28Genital tract atresia (HP:0001827)2.50140786
29Synostosis involving bones of the feet (HP:0009140)2.49018814
30Synostosis involving bones of the lower limbs (HP:0009138)2.49018814
31Abnormality of the renal medulla (HP:0100957)2.47021261
32Optic nerve hypoplasia (HP:0000609)2.45379280
33Ankle contracture (HP:0006466)2.43323673
34Aplasia/Hypoplasia of the uvula (HP:0010293)2.42957670
35Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.40591496
36Tarsal synostosis (HP:0008368)2.39988886
37Sclerocornea (HP:0000647)2.39695192
38Bifid tongue (HP:0010297)2.39352689
39Medial flaring of the eyebrow (HP:0010747)2.38249834
40Gastrointestinal atresia (HP:0002589)2.37245534
41Atonic seizures (HP:0010819)2.37100568
42Bilateral sensorineural hearing impairment (HP:0008619)2.35080815
43Central scotoma (HP:0000603)2.35036923
44Dynein arm defect of respiratory motile cilia (HP:0012255)2.33018161
45Absent/shortened dynein arms (HP:0200106)2.33018161
46Cerebellar dysplasia (HP:0007033)2.32475464
47Gait imbalance (HP:0002141)2.31684804
48Impulsivity (HP:0100710)2.29756225
49Maternal diabetes (HP:0009800)2.29356394
50Lissencephaly (HP:0001339)2.27409806
51Tubular atrophy (HP:0000092)2.25509626
52Pachygyria (HP:0001302)2.22490099
53Gaze-evoked nystagmus (HP:0000640)2.22305952
54Aplasia/Hypoplasia of the hallux (HP:0008362)2.22045925
55Duplicated collecting system (HP:0000081)2.21644123
56Congenital primary aphakia (HP:0007707)2.20919521
57Aplasia/Hypoplasia of the tongue (HP:0010295)2.20460063
58Microretrognathia (HP:0000308)2.20038570
59Anophthalmia (HP:0000528)2.17107442
60Hemiparesis (HP:0001269)2.16940607
61Distal arthrogryposis (HP:0005684)2.16157466
62Increased corneal curvature (HP:0100692)2.15152707
63Keratoconus (HP:0000563)2.15152707
64Carpal synostosis (HP:0009702)2.14756793
65Chorioretinal atrophy (HP:0000533)2.14740915
66Congenital stationary night blindness (HP:0007642)2.14297465
67Abnormality of chloride homeostasis (HP:0011422)2.14229119
68Abnormal ciliary motility (HP:0012262)2.11649387
69Nephrogenic diabetes insipidus (HP:0009806)2.08355426
70Postaxial hand polydactyly (HP:0001162)2.05670044
71Large for gestational age (HP:0001520)2.04505696
72Abnormality of the renal collecting system (HP:0004742)2.02973739
73Neonatal respiratory distress (HP:0002643)2.02659925
74Bilateral microphthalmos (HP:0007633)2.00105943
75Scotoma (HP:0000575)1.99684235
76Peripheral hypomyelination (HP:0007182)1.97223373
77Hyperventilation (HP:0002883)1.96237437
78Vaginal atresia (HP:0000148)1.96028270
79Aplasia/Hypoplasia of the tibia (HP:0005772)1.95940786
80Broad-based gait (HP:0002136)1.95072666
81Synostosis involving bones of the hand (HP:0004278)1.94485933
82Reticulocytopenia (HP:0001896)1.93137915
83Abnormality of the renal cortex (HP:0011035)1.90604430
84Tubulointerstitial nephritis (HP:0001970)1.87674063
85Pendular nystagmus (HP:0012043)1.87613479
86Synostosis of carpal bones (HP:0005048)1.87337271
87Postaxial foot polydactyly (HP:0001830)1.86464516
88Abnormality of the labia minora (HP:0012880)1.85891861
89Patellar aplasia (HP:0006443)1.85830986
90Cystic liver disease (HP:0006706)1.85779274
91Abnormality of incisor morphology (HP:0011063)1.85223435
92Renal dysplasia (HP:0000110)1.84235231
93Short tibia (HP:0005736)1.84203647
94Abnormality of the lower motor neuron (HP:0002366)1.82263376
95Aplasia/Hypoplasia of the sternum (HP:0006714)1.82151441
96Abnormality of the aortic arch (HP:0012303)1.81947211
97Anterior segment dysgenesis (HP:0007700)1.81467301
98Aplasia/Hypoplasia of the fovea (HP:0008060)1.79747666
99Hypoplasia of the fovea (HP:0007750)1.79747666
100Respiratory distress (HP:0002098)1.79336686

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAF14.38893454
2ADRBK23.34221925
3MAP4K23.15153875
4TNIK2.94285661
5NTRK22.88853922
6MAP3K92.87952994
7CASK2.64877040
8PINK12.40192718
9FRK2.36381647
10NTRK12.27219001
11FLT32.12961809
12INSRR2.09538177
13TEC2.05115287
14BCKDK1.93617057
15SIK21.83468430
16WNK11.70859902
17DAPK21.67453776
18ACVR1B1.57633299
19BCR1.54498520
20MAPK131.49883659
21CSF1R1.42640951
22ZAK1.40851033
23CSNK1G21.39158058
24MARK11.38836372
25GRK11.38449339
26WNK41.36850587
27BMPR1B1.36701820
28OXSR11.34312415
29PKN21.29421412
30DYRK21.28952277
31IKBKE1.28938049
32EPHA41.25601581
33WNK31.21640529
34STK161.20603269
35PLK21.10617103
36CHUK1.09413401
37PKN11.03730708
38NME11.02480489
39KIT0.99715510
40NTRK30.96613455
41CSNK1G30.95461258
42STK390.94910106
43MAP3K40.94342490
44SRPK10.89604794
45STK110.85577412
46ADRBK10.83345988
47TGFBR10.83011310
48MAP2K70.81449678
49CDK190.81054160
50TIE10.79415672
51PRKCG0.76482406
52CSNK1A1L0.76459824
53ITK0.75935004
54SGK20.75209827
55VRK10.74004020
56PRKCE0.72025540
57CSNK1G10.70249721
58IRAK10.69722906
59TRIM280.67139693
60IKBKB0.64146002
61MAPK150.60290469
62CHEK20.60191493
63ABL20.56953861
64TLK10.54216624
65DYRK30.53364564
66PTK60.53035971
67CAMK2B0.52775400
68NUAK10.52488276
69NEK20.52216622
70PRKCH0.49907023
71CAMK2A0.49763086
72PRKCQ0.49623055
73PRKACA0.49101965
74IRAK40.47189933
75PAK30.46267945
76RPS6KA50.45152598
77CSNK1A10.44037695
78IGF1R0.43983554
79PIK3CA0.43129743
80SGK4940.42328251
81SGK2230.42328251
82CAMK10.42167926
83BTK0.41743909
84PLK30.41354516
85PRKG10.40495171
86PLK10.40399612
87TXK0.37700524
88RPS6KB10.36938428
89MKNK10.36729943
90PRKD10.35382109
91STK40.34657224
92IRAK20.34473461
93AKT10.32631922
94PIK3CG0.32491622
95CAMK2D0.32483537
96EPHA30.31933486
97OBSCN0.31157984
98PRKCZ0.30580841
99GRK50.29593076
100JAK20.29386785

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.77620724
2Nicotine addiction_Homo sapiens_hsa050332.98537521
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.91771007
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.80413575
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.63930110
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.49975786
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.48924938
8ABC transporters_Homo sapiens_hsa020102.17340568
9Propanoate metabolism_Homo sapiens_hsa006402.08847823
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.99370065
11Morphine addiction_Homo sapiens_hsa050321.98714513
12Olfactory transduction_Homo sapiens_hsa047401.86311220
13Basal transcription factors_Homo sapiens_hsa030221.80180984
14Butanoate metabolism_Homo sapiens_hsa006501.79478930
15Linoleic acid metabolism_Homo sapiens_hsa005911.71368087
16Taste transduction_Homo sapiens_hsa047421.70311446
17Primary bile acid biosynthesis_Homo sapiens_hsa001201.69808810
18Asthma_Homo sapiens_hsa053101.63950854
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.63568235
20Tryptophan metabolism_Homo sapiens_hsa003801.60299723
21GABAergic synapse_Homo sapiens_hsa047271.59815621
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.53878638
23Salivary secretion_Homo sapiens_hsa049701.50127641
24Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.42834652
25Circadian entrainment_Homo sapiens_hsa047131.39427559
26Histidine metabolism_Homo sapiens_hsa003401.37701475
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.36119353
28Notch signaling pathway_Homo sapiens_hsa043301.35211440
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.33846555
30Selenocompound metabolism_Homo sapiens_hsa004501.29948993
31Oxidative phosphorylation_Homo sapiens_hsa001901.26799620
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.25744807
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.22173591
34Cardiac muscle contraction_Homo sapiens_hsa042601.20577085
35Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.19344236
36Glutamatergic synapse_Homo sapiens_hsa047241.14922382
37Ether lipid metabolism_Homo sapiens_hsa005651.13144435
38Ribosome_Homo sapiens_hsa030101.11555647
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.10912466
40Retinol metabolism_Homo sapiens_hsa008301.10412253
41Parkinsons disease_Homo sapiens_hsa050121.09261060
42Phototransduction_Homo sapiens_hsa047441.05585104
43Cocaine addiction_Homo sapiens_hsa050301.04437865
44Homologous recombination_Homo sapiens_hsa034400.97222494
45Pentose and glucuronate interconversions_Homo sapiens_hsa000400.95559560
46Vitamin digestion and absorption_Homo sapiens_hsa049770.95289675
47Graft-versus-host disease_Homo sapiens_hsa053320.92040725
48beta-Alanine metabolism_Homo sapiens_hsa004100.91443340
49Basal cell carcinoma_Homo sapiens_hsa052170.91013301
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86295431
51Chemical carcinogenesis_Homo sapiens_hsa052040.85661723
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85347213
53Hedgehog signaling pathway_Homo sapiens_hsa043400.84837845
54Dopaminergic synapse_Homo sapiens_hsa047280.79950696
55Protein export_Homo sapiens_hsa030600.79765167
56Arachidonic acid metabolism_Homo sapiens_hsa005900.79706152
57Fanconi anemia pathway_Homo sapiens_hsa034600.78961356
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.78637754
59Huntingtons disease_Homo sapiens_hsa050160.78017072
60Gastric acid secretion_Homo sapiens_hsa049710.76567348
61Nitrogen metabolism_Homo sapiens_hsa009100.75738734
62Insulin secretion_Homo sapiens_hsa049110.75634834
63Autoimmune thyroid disease_Homo sapiens_hsa053200.74395923
64Type I diabetes mellitus_Homo sapiens_hsa049400.73978937
65Renin secretion_Homo sapiens_hsa049240.73948528
66Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.72759130
67Hippo signaling pathway_Homo sapiens_hsa043900.72693786
68Dilated cardiomyopathy_Homo sapiens_hsa054140.72086969
69Serotonergic synapse_Homo sapiens_hsa047260.71833668
70Glycerolipid metabolism_Homo sapiens_hsa005610.71603706
71Peroxisome_Homo sapiens_hsa041460.71094726
72Allograft rejection_Homo sapiens_hsa053300.70530449
73Cholinergic synapse_Homo sapiens_hsa047250.68455977
74Long-term depression_Homo sapiens_hsa047300.68373221
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65337057
76Axon guidance_Homo sapiens_hsa043600.64441204
77Alzheimers disease_Homo sapiens_hsa050100.64063844
78Calcium signaling pathway_Homo sapiens_hsa040200.59698177
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58293775
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56664427
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55452904
82Caffeine metabolism_Homo sapiens_hsa002320.54829787
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53761166
84Fat digestion and absorption_Homo sapiens_hsa049750.52174952
85N-Glycan biosynthesis_Homo sapiens_hsa005100.50895427
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50036768
87Fatty acid degradation_Homo sapiens_hsa000710.50010184
88Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49219325
89Pyruvate metabolism_Homo sapiens_hsa006200.47933172
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47550336
91Nucleotide excision repair_Homo sapiens_hsa034200.46553556
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45959177
93Metabolic pathways_Homo sapiens_hsa011000.43554699
94Type II diabetes mellitus_Homo sapiens_hsa049300.43388396
95Starch and sucrose metabolism_Homo sapiens_hsa005000.41931793
96Systemic lupus erythematosus_Homo sapiens_hsa053220.41885686
97Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.39527495
98Purine metabolism_Homo sapiens_hsa002300.37912859
99Estrogen signaling pathway_Homo sapiens_hsa049150.37338210
100TGF-beta signaling pathway_Homo sapiens_hsa043500.35963691

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