ZNF407

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a zinc finger protein whose exact function is not known. It may be involved in transcriptional regulation. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K36 demethylation (GO:0070544)4.89006335
2phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.56440551
3nuclear pore complex assembly (GO:0051292)4.51050403
4positive regulation of gamma-delta T cell activation (GO:0046645)4.37723978
5monoubiquitinated protein deubiquitination (GO:0035520)4.12029621
6cellular response to ethanol (GO:0071361)4.08577862
7interkinetic nuclear migration (GO:0022027)4.05686314
8nuclear pore organization (GO:0006999)4.03353361
9histone H3-K4 trimethylation (GO:0080182)3.93311775
10regulation of B cell receptor signaling pathway (GO:0050855)3.74078697
11establishment of protein localization to Golgi (GO:0072600)3.68067403
12histone mRNA catabolic process (GO:0071044)3.57553293
13histone H3-K9 demethylation (GO:0033169)3.50863798
14dosage compensation (GO:0007549)3.50273196
15regulation of gamma-delta T cell differentiation (GO:0045586)3.38726368
16positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.34761089
17cytoplasmic mRNA processing body assembly (GO:0033962)3.33776142
18detection of molecule of bacterial origin (GO:0032490)3.33336217
19pore complex assembly (GO:0046931)3.32542108
20retrograde transport, vesicle recycling within Golgi (GO:0000301)3.31521966
21regulation of gamma-delta T cell activation (GO:0046643)3.29257895
22phospholipid translocation (GO:0045332)3.28970009
23lipid translocation (GO:0034204)3.28970009
24peptidyl-lysine trimethylation (GO:0018023)3.28750723
25protein K48-linked deubiquitination (GO:0071108)3.28537110
26histone lysine demethylation (GO:0070076)3.27851472
27regulation of necroptotic process (GO:0060544)3.27396315
28protein targeting to Golgi (GO:0000042)3.26109332
29B cell receptor signaling pathway (GO:0050853)3.23060216
30nucleus localization (GO:0051647)3.18204181
31positive T cell selection (GO:0043368)3.12457880
32histone demethylation (GO:0016577)3.10663337
33negative regulation of DNA repair (GO:0045738)3.02725515
34nerve growth factor signaling pathway (GO:0038180)2.96106135
35hepatocyte apoptotic process (GO:0097284)2.92843092
36protein K11-linked deubiquitination (GO:0035871)2.92550279
37cellular extravasation (GO:0045123)2.92121888
38mitotic sister chromatid cohesion (GO:0007064)2.91223242
39negative T cell selection (GO:0043383)2.86870161
40interleukin-6-mediated signaling pathway (GO:0070102)2.83394432
41establishment of nucleus localization (GO:0040023)2.81942379
42neutrophil mediated immunity (GO:0002446)2.79930658
43Golgi to endosome transport (GO:0006895)2.79919158
44negative thymic T cell selection (GO:0045060)2.78684680
45regulation of RNA export from nucleus (GO:0046831)2.78082373
46protein targeting to lysosome (GO:0006622)2.77828114
47establishment of protein localization to vacuole (GO:0072666)2.77828114
48protein targeting to vacuole (GO:0006623)2.77828114
49regulation of protein polyubiquitination (GO:1902914)2.76372455
50peptidyl-lysine methylation (GO:0018022)2.76053763
51pericardium development (GO:0060039)2.74834422
52histone H3-K4 methylation (GO:0051568)2.73911434
53positive regulation of granulocyte differentiation (GO:0030854)2.71084269
54protein demethylation (GO:0006482)2.70928372
55protein dealkylation (GO:0008214)2.70928372
56oocyte development (GO:0048599)2.70149965
57N-terminal protein amino acid acetylation (GO:0006474)2.69483393
58regulation of interleukin-12 biosynthetic process (GO:0045075)2.67635387
59antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.67401511
60histone lysine methylation (GO:0034968)2.67249408
61histone H3-K9 modification (GO:0061647)2.63865116
62positive regulation of developmental pigmentation (GO:0048087)2.62896223
63regulation of establishment of cell polarity (GO:2000114)2.61687584
64early endosome to late endosome transport (GO:0045022)2.61474038
65protein K63-linked deubiquitination (GO:0070536)2.60779347
66fibroblast migration (GO:0010761)2.59324357
67neural tube formation (GO:0001841)2.59169556
68necrotic cell death (GO:0070265)2.58629721
69protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.57148912
70myeloid leukocyte mediated immunity (GO:0002444)2.57129567
71striated muscle atrophy (GO:0014891)2.56487066
72macrophage activation involved in immune response (GO:0002281)2.55993297
73positive regulation of B cell differentiation (GO:0045579)2.54850833
74positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.54722816
75negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.53987485
76negative regulation of cell killing (GO:0031342)2.53987485
77microglial cell activation (GO:0001774)2.53229464
78I-kappaB phosphorylation (GO:0007252)2.51701272
79definitive hemopoiesis (GO:0060216)2.50480654
80regulation of fibroblast apoptotic process (GO:2000269)2.49301623
81negative regulation of interleukin-12 production (GO:0032695)2.49148018
82piRNA metabolic process (GO:0034587)2.48841943
83skeletal muscle adaptation (GO:0043501)2.47550895
84phosphatidylinositol dephosphorylation (GO:0046856)2.47370344
85positive regulation by symbiont of host defense response (GO:0052509)2.47189396
86modulation by symbiont of host defense response (GO:0052031)2.47189396
87modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.47189396
88modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.47189396
89positive regulation by organism of defense response of other organism involved in symbiotic interact2.47189396
90modulation by symbiont of host immune response (GO:0052553)2.47189396
91regulation of pigment cell differentiation (GO:0050932)2.43789041
92regulation of NFAT protein import into nucleus (GO:0051532)2.43538190
93peptidyl-threonine phosphorylation (GO:0018107)2.42967032
94histone H3-K9 methylation (GO:0051567)2.42318595
95necroptotic process (GO:0070266)2.41781249
96programmed necrotic cell death (GO:0097300)2.41177286
97positive regulation of DNA-templated transcription, initiation (GO:2000144)2.40788947
98regulation of MHC class I biosynthetic process (GO:0045343)2.40418087
99sister chromatid cohesion (GO:0007062)2.39515512
100positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.36633072

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.11799364
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.87027455
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.57992402
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.28277522
5SMAD_19615063_ChIP-ChIP_OVARY_Human3.22165072
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.94404040
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.73978641
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.20805835
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.16074096
10SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.10463347
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.07169086
12RUNX_20019798_ChIP-Seq_JUKART_Human2.03363972
13GATA1_22025678_ChIP-Seq_K562_Human2.00060784
14GBX2_23144817_ChIP-Seq_PC3_Human1.99256309
15POU3F2_20337985_ChIP-ChIP_501MEL_Human1.90129569
16SCL_19346495_ChIP-Seq_HPC-7_Human1.88657763
17TP53_16413492_ChIP-PET_HCT116_Human1.87651652
18AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.82470484
19CDX2_19796622_ChIP-Seq_MESCs_Mouse1.81220093
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.80724501
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.80664512
22MYB_21317192_ChIP-Seq_ERMYB_Mouse1.76537591
23IRF8_27001747_Chip-Seq_BMDM_Mouse1.76047385
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.74433181
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.73528278
26EGR1_19374776_ChIP-ChIP_THP-1_Human1.72357039
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.68237400
28ZNF217_24962896_ChIP-Seq_MCF-7_Human1.68086182
29VDR_24787735_ChIP-Seq_THP-1_Human1.61168880
30RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57290218
31IRF8_21731497_ChIP-ChIP_J774_Mouse1.56557404
32TAF15_26573619_Chip-Seq_HEK293_Human1.55232319
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55087570
34STAT3_23295773_ChIP-Seq_U87_Human1.54560818
35TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.53224469
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.52999586
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.51707925
38MYB_26560356_Chip-Seq_TH2_Human1.50181420
39AHR_22903824_ChIP-Seq_MCF-7_Human1.42241576
40NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.41181365
41IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.39568447
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.38836406
43CTNNB1_20460455_ChIP-Seq_HCT116_Human1.37507236
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35664670
45IGF1R_20145208_ChIP-Seq_DFB_Human1.35339715
46SMAD4_21799915_ChIP-Seq_A2780_Human1.35187075
47TCF4_23295773_ChIP-Seq_U87_Human1.33849729
48CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.32510065
49AR_21572438_ChIP-Seq_LNCaP_Human1.31350659
50ARNT_22903824_ChIP-Seq_MCF-7_Human1.29778712
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28746217
52ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.25846197
53ER_23166858_ChIP-Seq_MCF-7_Human1.24865200
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24737650
55GATA2_21666600_ChIP-Seq_HMVEC_Human1.24069399
56CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22194219
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21977999
58PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21125697
59NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19924541
60NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19924541
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.19722491
62FOXM1_26456572_ChIP-Seq_MCF-7_Human1.19109713
63IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.19016484
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.18771375
65MYB_26560356_Chip-Seq_TH1_Human1.18702832
66BRD4_25478319_ChIP-Seq_HGPS_Human1.17417942
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17192757
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17167838
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.16952864
70ESR1_20079471_ChIP-ChIP_T-47D_Human1.16409596
71NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.16014468
72GATA3_27048872_Chip-Seq_THYMUS_Human1.15930744
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15920925
74* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.15673194
75CBP_20019798_ChIP-Seq_JUKART_Human1.15512355
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15512355
77KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.14950429
78FUS_26573619_Chip-Seq_HEK293_Human1.14716797
79FOXO3_23340844_ChIP-Seq_DLD1_Human1.13908739
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.13431946
81BP1_19119308_ChIP-ChIP_Hs578T_Human1.11733308
82SPI1_23127762_ChIP-Seq_K562_Human1.10978173
83GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10765965
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10519673
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.07779015
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07053495
87POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07053495
88PRDM14_20953172_ChIP-Seq_ESCs_Human1.06552098
89SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05389554
90E2F1_18555785_Chip-Seq_ESCs_Mouse1.04932493
91FLI1_21867929_ChIP-Seq_TH2_Mouse1.03746084
92ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.03657413
93TP63_23658742_ChIP-Seq_EP156T_Human1.02219467
94NFE2_27457419_Chip-Seq_LIVER_Mouse1.00975633
95BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00685085
96P300_19829295_ChIP-Seq_ESCs_Human1.00579876
97GATA3_26560356_Chip-Seq_TH2_Human0.99494758
98EWS_26573619_Chip-Seq_HEK293_Human0.99375367
99PU_27001747_Chip-Seq_BMDM_Mouse0.97342091
100OCT4_21477851_ChIP-Seq_ESCs_Mouse0.95172469

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.46167104
2MP0008057_abnormal_DNA_replication5.45015273
3MP0002009_preneoplasia3.18408258
4MP0003787_abnormal_imprinting2.92036490
5MP0003763_abnormal_thymus_physiology2.87703131
6MP0003300_gastrointestinal_ulcer2.50262827
7MP0010352_gastrointestinal_tract_polyps2.41398750
8MP0002166_altered_tumor_susceptibility2.38887885
9MP0004808_abnormal_hematopoietic_stem2.27221214
10MP0003183_abnormal_peptide_metabolism2.24148089
11MP0003828_pulmonary_edema2.10905411
12MP0002396_abnormal_hematopoietic_system2.06166078
13MP0003045_fibrosis2.05036459
14MP0003724_increased_susceptibility_to2.02801139
15MP0003303_peritoneal_inflammation1.94876222
16MP0003656_abnormal_erythrocyte_physiolo1.88274343
17MP0001835_abnormal_antigen_presentation1.83551832
18MP0000015_abnormal_ear_pigmentation1.82936567
19MP0008877_abnormal_DNA_methylation1.80668011
20MP0002332_abnormal_exercise_endurance1.79370045
21MP0008260_abnormal_autophagy1.76027829
22MP0001800_abnormal_humoral_immune1.70600837
23MP0003091_abnormal_cell_migration1.64261725
24MP0003950_abnormal_plasma_membrane1.61415399
25MP0002006_tumorigenesis1.54668311
26MP0005310_abnormal_salivary_gland1.44386780
27MP0003221_abnormal_cardiomyocyte_apopto1.41587119
28MP0004381_abnormal_hair_follicle1.41572521
29MP0002398_abnormal_bone_marrow1.40492248
30MP0003646_muscle_fatigue1.38314445
31MP0004484_altered_response_of1.37878809
32MP0004084_abnormal_cardiac_muscle1.36381902
33MP0000685_abnormal_immune_system1.35921746
34MP0010307_abnormal_tumor_latency1.34906662
35MP0005076_abnormal_cell_differentiation1.32794488
36MP0002452_abnormal_antigen_presenting1.29513020
37MP0002420_abnormal_adaptive_immunity1.27021780
38MP0004036_abnormal_muscle_relaxation1.25421908
39MP0005397_hematopoietic_system_phenotyp1.24487004
40MP0001545_abnormal_hematopoietic_system1.24487004
41MP0000427_abnormal_hair_cycle1.24154858
42MP0002723_abnormal_immune_serum1.24116574
43MP0001819_abnormal_immune_cell1.22873118
44MP0000703_abnormal_thymus_morphology1.22326452
45MP0009115_abnormal_fat_cell1.21732500
46MP0002419_abnormal_innate_immunity1.21650024
47MP0002168_other_aberrant_phenotype1.20598918
48MP0010678_abnormal_skin_adnexa1.19940632
49MP0004130_abnormal_muscle_cell1.19721026
50MP0000383_abnormal_hair_follicle1.15267771
51MP0000689_abnormal_spleen_morphology1.14900125
52MP0000371_diluted_coat_color1.14666133
53MP0000716_abnormal_immune_system1.14417622
54MP0002877_abnormal_melanocyte_morpholog1.14292709
55MP0005451_abnormal_body_composition1.12752453
56MP0005000_abnormal_immune_tolerance1.11111827
57MP0005266_abnormal_metabolism1.08725695
58MP0003868_abnormal_feces_composition1.07583723
59MP0002722_abnormal_immune_system1.06594156
60MP0001790_abnormal_immune_system1.06028196
61MP0005387_immune_system_phenotype1.06028196
62MP0005464_abnormal_platelet_physiology1.01413815
63MP0003172_abnormal_lysosome_physiology1.01403967
64MP0005174_abnormal_tail_pigmentation1.01401236
65MP0002405_respiratory_system_inflammati1.01194435
66MP0004233_abnormal_muscle_weight0.99976249
67MP0002998_abnormal_bone_remodeling0.98472028
68MP0005621_abnormal_cell_physiology0.97723065
69MP0005164_abnormal_response_to0.97400215
70MP0000465_gastrointestinal_hemorrhage0.95716822
71MP0001915_intracranial_hemorrhage0.95653193
72MP0006054_spinal_hemorrhage0.94836172
73MP0005409_darkened_coat_color0.94053320
74MP0008004_abnormal_stomach_pH0.93612968
75MP0005075_abnormal_melanosome_morpholog0.93545114
76MP0005671_abnormal_response_to0.93527949
77MP0010234_abnormal_vibrissa_follicle0.91391698
78MP0001851_eye_inflammation0.88741318
79MP0004947_skin_inflammation0.88513389
80MP0003252_abnormal_bile_duct0.86651010
81MP0005025_abnormal_response_to0.85612328
82MP0004883_abnormal_blood_vessel0.85557628
83MP0003690_abnormal_glial_cell0.85064625
84MP0002429_abnormal_blood_cell0.84185406
85MP0002928_abnormal_bile_duct0.81595244
86MP0003436_decreased_susceptibility_to0.81073998
87MP0005376_homeostasis/metabolism_phenot0.80948896
88MP0010155_abnormal_intestine_physiology0.80453000
89MP0002138_abnormal_hepatobiliary_system0.79343792
90MP0003121_genomic_imprinting0.78280320
91MP0003191_abnormal_cellular_cholesterol0.77747916
92MP0005395_other_phenotype0.76457485
93MP0008961_abnormal_basal_metabolism0.76296416
94MP0003866_abnormal_defecation0.75820164
95MP0003705_abnormal_hypodermis_morpholog0.72024140
96MP0003890_abnormal_embryonic-extraembry0.71720759
97MP0006082_CNS_inflammation0.70255902
98MP0005275_abnormal_skin_tensile0.69405726
99MP0005384_cellular_phenotype0.67866078
100MP0002019_abnormal_tumor_incidence0.65440032

Predicted human phenotypes

RankGene SetZ-score
1Heterotopia (HP:0002282)3.51431697
2Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.41416902
3T lymphocytopenia (HP:0005403)3.36919173
4Truncal obesity (HP:0001956)3.34720160
5Abnormality of the fingertips (HP:0001211)3.31614747
6Papillary thyroid carcinoma (HP:0002895)3.24294195
7Abnormality of T cell number (HP:0011839)3.16321977
8Chronic hepatic failure (HP:0100626)2.96571217
9Menstrual irregularities (HP:0000858)2.87672464
10Subacute progressive viral hepatitis (HP:0006572)2.75888489
11Prominent nose (HP:0000448)2.69877603
12Recurrent bacterial skin infections (HP:0005406)2.69660227
13Acute myeloid leukemia (HP:0004808)2.59257462
14Hematochezia (HP:0002573)2.58989422
15Fair hair (HP:0002286)2.54912394
16Autoimmune hemolytic anemia (HP:0001890)2.53500955
17Eczematoid dermatitis (HP:0000976)2.53491204
18Spontaneous hematomas (HP:0007420)2.53362838
19Narrow palate (HP:0000189)2.53225116
20Volvulus (HP:0002580)2.47380683
21Protruding tongue (HP:0010808)2.46936025
22Sandal gap (HP:0001852)2.44593713
23Submucous cleft hard palate (HP:0000176)2.39259677
24Difficulty running (HP:0009046)2.34530995
25Thyroiditis (HP:0100646)2.32052451
26Spondylolisthesis (HP:0003302)2.31797095
27Gingival bleeding (HP:0000225)2.31567031
28Deep philtrum (HP:0002002)2.31341445
29Hypoplastic iliac wings (HP:0002866)2.29974907
30Overgrowth (HP:0001548)2.29875830
31Dysmetric saccades (HP:0000641)2.26379617
32Absent frontal sinuses (HP:0002688)2.24356825
33Recurrent abscess formation (HP:0002722)2.23770470
34Gingivitis (HP:0000230)2.23495568
35Genetic anticipation (HP:0003743)2.22949949
36Curly hair (HP:0002212)2.22623334
37Cystic hygroma (HP:0000476)2.21685683
38Generalized hypopigmentation of hair (HP:0011358)2.20272258
39Lip pit (HP:0100267)2.14569113
40Widely spaced teeth (HP:0000687)2.10222931
41Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.10197401
42Portal hypertension (HP:0001409)2.07912952
43Colitis (HP:0002583)2.07157179
44Chest pain (HP:0100749)2.03738728
45Recurrent viral infections (HP:0004429)2.03194991
46Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.03075136
47Viral hepatitis (HP:0006562)2.01880253
48Cubitus valgus (HP:0002967)2.00099651
49Recurrent fungal infections (HP:0002841)1.98914989
50Broad face (HP:0000283)1.96751859
51Neonatal hypoglycemia (HP:0001998)1.96595588
52Abnormality of the epiphyses of the hand (HP:0005924)1.95479514
53Abnormal delayed hypersensitivity skin test (HP:0002963)1.95458402
54Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.94852308
55Aortic aneurysm (HP:0004942)1.94462061
56Conjunctival telangiectasia (HP:0000524)1.93331905
57Arterial thrombosis (HP:0004420)1.89698621
58Amaurosis fugax (HP:0100576)1.87302419
59Gaze-evoked nystagmus (HP:0000640)1.87279365
60Tapered finger (HP:0001182)1.87077174
61Autoimmune thrombocytopenia (HP:0001973)1.85272288
62Thickened calvaria (HP:0002684)1.85197494
63Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.84906688
64Anhidrosis (HP:0000970)1.83194991
65Abnormality of the hepatic vasculature (HP:0006707)1.81016354
66Hyperventilation (HP:0002883)1.80974213
67Hyperkalemia (HP:0002153)1.79982498
68Fatigue (HP:0012378)1.79670563
69Thyroid carcinoma (HP:0002890)1.79603587
70Subaortic stenosis (HP:0001682)1.78521600
71Abnormality of the left ventricular outflow tract (HP:0011103)1.78521600
72Periodontitis (HP:0000704)1.77628196
73Low anterior hairline (HP:0000294)1.76126497
74Tubulointerstitial nephritis (HP:0001970)1.76103445
75Abnormality of the vasculature of the conjunctiva (HP:0008054)1.74831041
76Long eyelashes (HP:0000527)1.74677721
77Neoplasm of the oral cavity (HP:0100649)1.73935289
78Macroorchidism (HP:0000053)1.73641565
79Increased number of teeth (HP:0011069)1.72209886
80Rhabdomyosarcoma (HP:0002859)1.69850412
81Coarse hair (HP:0002208)1.68439316
82Dislocated radial head (HP:0003083)1.67889832
83Syringomyelia (HP:0003396)1.67883494
84Spinal cord lesions (HP:0100561)1.67883494
85Chronic diarrhea (HP:0002028)1.66526432
86Bladder neoplasm (HP:0009725)1.65529473
87Bladder carcinoma (HP:0002862)1.65529473
88Abnormal hair whorl (HP:0010721)1.65511492
89Abnormality of the wing of the ilium (HP:0011867)1.65381281
90Neoplasm of the tracheobronchial system (HP:0100552)1.65096537
91Resting tremor (HP:0002322)1.65009263
92Short chin (HP:0000331)1.64453746
93Osteolytic defects of the hand bones (HP:0009699)1.64065347
94Osteolytic defects of the phalanges of the hand (HP:0009771)1.64065347
95Capillary hemangiomas (HP:0005306)1.64015545
96IgA deficiency (HP:0002720)1.63727846
97Transitional cell carcinoma of the bladder (HP:0006740)1.62685526
98Relative macrocephaly (HP:0004482)1.62479229
99Inflammation of the large intestine (HP:0002037)1.59925870
100Large earlobe (HP:0009748)1.59826306

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT33.52615489
2FRK3.42632235
3CDK122.98597939
4SGK22.24112284
5ACVR1B2.23998970
6BLK2.21812834
7MAP3K132.21232200
8CAMK1G2.20070943
9PIK3CG2.18017920
10BRD42.10215385
11CAMK1D1.98166286
12TAOK31.89039377
13MELK1.82317431
14WNK11.76724712
15TGFBR21.76310802
16SGK31.71404935
17TRPM71.65913995
18MAP3K71.64764280
19MAP3K141.63597270
20TEC1.60361995
21NLK1.60048000
22JAK11.49385333
23IKBKE1.45967801
24FGFR31.41691334
25NEK91.36360637
26CAMKK21.33177652
27BTK1.31710033
28RIPK41.28688586
29EIF2AK31.28092176
30MARK21.16581702
31SGK2231.15780465
32SGK4941.15780465
33HCK1.08808029
34EPHA31.07579252
35TTN1.07399321
36JAK31.04589362
37MAP2K31.02548998
38SYK1.02077587
39IRAK40.97993047
40PIK3CA0.97909664
41OBSCN0.97294891
42IRAK10.95686880
43PRKAA20.95585749
44BMPR20.94407419
45ZAP700.93885630
46MAP3K20.93579455
47CHUK0.92432501
48CSK0.90461735
49CAMK40.87462111
50MAP3K60.86901677
51NEK60.86461191
52MAP3K50.85901901
53FGR0.82444535
54MAP4K10.81262584
55JAK20.81192197
56RPS6KB10.80771134
57FES0.79034182
58ITK0.78658004
59RAF10.77862913
60PDK10.77701501
61TYK20.77474685
62PDGFRB0.76360666
63LCK0.76030276
64PIM10.75877097
65MAP3K40.72536156
66SGK10.71329218
67STK380.70030618
68CDK90.68169234
69RET0.66948630
70MARK30.64988421
71MAP3K10.64723638
72MAP2K40.62906865
73KSR10.62475864
74IKBKB0.62287030
75NUAK10.62171291
76STK110.61409501
77TXK0.58923067
78PTK2B0.58732414
79MAPK110.58049539
80LYN0.57796013
81MTOR0.57418212
82LATS10.56403152
83BMPR1B0.55284995
84CDC42BPA0.52772342
85CDK60.51343294
86RPS6KB20.51193643
87KSR20.50400178
88PRPF4B0.48150192
89PNCK0.47625906
90MAPK70.46649254
91YES10.45588867
92PLK20.45567723
93BRSK20.45490213
94CSF1R0.45279919
95STK100.44676731
96FER0.43571778
97STK40.43566460
98EGFR0.42582629
99EEF2K0.41561345
100MAPK100.41223758

Predicted pathways (KEGG)

RankGene SetZ-score
1Dorso-ventral axis formation_Homo sapiens_hsa043202.39714823
2B cell receptor signaling pathway_Homo sapiens_hsa046622.04847967
3Non-small cell lung cancer_Homo sapiens_hsa052231.74765701
4Phosphatidylinositol signaling system_Homo sapiens_hsa040701.74251665
5Osteoclast differentiation_Homo sapiens_hsa043801.68677559
6mTOR signaling pathway_Homo sapiens_hsa041501.66810049
7Inositol phosphate metabolism_Homo sapiens_hsa005621.61473129
8Pancreatic cancer_Homo sapiens_hsa052121.59419324
9Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.58132820
10T cell receptor signaling pathway_Homo sapiens_hsa046601.56182953
11FoxO signaling pathway_Homo sapiens_hsa040681.56016840
12Acute myeloid leukemia_Homo sapiens_hsa052211.51027279
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.48386271
14NOD-like receptor signaling pathway_Homo sapiens_hsa046211.43896590
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.42894529
16Endometrial cancer_Homo sapiens_hsa052131.39458806
17Platelet activation_Homo sapiens_hsa046111.37120144
18TNF signaling pathway_Homo sapiens_hsa046681.35931498
19Chronic myeloid leukemia_Homo sapiens_hsa052201.34813955
20Measles_Homo sapiens_hsa051621.33186663
21Leishmaniasis_Homo sapiens_hsa051401.31369705
22Prolactin signaling pathway_Homo sapiens_hsa049171.31189430
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.31168844
24Hepatitis B_Homo sapiens_hsa051611.30509267
25Colorectal cancer_Homo sapiens_hsa052101.30339398
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.30317891
27Prostate cancer_Homo sapiens_hsa052151.26600566
28AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.26052354
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.21151302
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.19417097
31Neurotrophin signaling pathway_Homo sapiens_hsa047221.19021229
32Thyroid hormone signaling pathway_Homo sapiens_hsa049191.18646736
33Influenza A_Homo sapiens_hsa051641.16395971
34Renal cell carcinoma_Homo sapiens_hsa052111.14475362
35Tuberculosis_Homo sapiens_hsa051521.13041832
36Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.10612458
37Toxoplasmosis_Homo sapiens_hsa051451.10110245
38Circadian rhythm_Homo sapiens_hsa047101.06364812
39ErbB signaling pathway_Homo sapiens_hsa040121.04395931
40Longevity regulating pathway - mammal_Homo sapiens_hsa042111.04090826
41Type II diabetes mellitus_Homo sapiens_hsa049301.03053073
42Lysine degradation_Homo sapiens_hsa003101.03037420
43Glioma_Homo sapiens_hsa052141.02692979
44Insulin resistance_Homo sapiens_hsa049311.02573096
45Small cell lung cancer_Homo sapiens_hsa052221.01373249
46Viral carcinogenesis_Homo sapiens_hsa052031.00530138
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.98744450
48Adherens junction_Homo sapiens_hsa045200.98020547
49MicroRNAs in cancer_Homo sapiens_hsa052060.97785244
50Choline metabolism in cancer_Homo sapiens_hsa052310.96700056
51Systemic lupus erythematosus_Homo sapiens_hsa053220.93449700
52Chemokine signaling pathway_Homo sapiens_hsa040620.92834551
53Regulation of autophagy_Homo sapiens_hsa041400.88371431
54Hepatitis C_Homo sapiens_hsa051600.88317228
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.88243276
56VEGF signaling pathway_Homo sapiens_hsa043700.88224605
57Thyroid cancer_Homo sapiens_hsa052160.87545989
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.86875988
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86142304
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.84616114
61Non-homologous end-joining_Homo sapiens_hsa034500.83698496
62Herpes simplex infection_Homo sapiens_hsa051680.82572882
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.80518488
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78641795
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78022141
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.77509367
67Apoptosis_Homo sapiens_hsa042100.76781665
68Staphylococcus aureus infection_Homo sapiens_hsa051500.75952265
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75917078
70Long-term potentiation_Homo sapiens_hsa047200.75844549
71Legionellosis_Homo sapiens_hsa051340.73820124
72Fatty acid biosynthesis_Homo sapiens_hsa000610.73070016
73GnRH signaling pathway_Homo sapiens_hsa049120.72662270
74ABC transporters_Homo sapiens_hsa020100.72638875
75Focal adhesion_Homo sapiens_hsa045100.72502069
76Primary immunodeficiency_Homo sapiens_hsa053400.71552244
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71148921
78Proteoglycans in cancer_Homo sapiens_hsa052050.70956899
79Long-term depression_Homo sapiens_hsa047300.70175871
80Graft-versus-host disease_Homo sapiens_hsa053320.69749740
81MAPK signaling pathway_Homo sapiens_hsa040100.66939986
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66811286
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.66725148
84Malaria_Homo sapiens_hsa051440.66616582
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64978280
86Hematopoietic cell lineage_Homo sapiens_hsa046400.64614621
87Estrogen signaling pathway_Homo sapiens_hsa049150.63662988
88Ovarian steroidogenesis_Homo sapiens_hsa049130.61031035
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.59575096
90HIF-1 signaling pathway_Homo sapiens_hsa040660.58697969
91Insulin signaling pathway_Homo sapiens_hsa049100.58449062
92Oxytocin signaling pathway_Homo sapiens_hsa049210.58227316
93HTLV-I infection_Homo sapiens_hsa051660.55679635
94Renin secretion_Homo sapiens_hsa049240.55082760
95Amoebiasis_Homo sapiens_hsa051460.54401544
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53627776
97Alcoholism_Homo sapiens_hsa050340.51565132
98Viral myocarditis_Homo sapiens_hsa054160.50963376
99Autoimmune thyroid disease_Homo sapiens_hsa053200.50474356
100Melanoma_Homo sapiens_hsa052180.49245303

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