ZNF408

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains ten tandem zinc fingers and an N-terminal SET domain, so it is likely a DNA binding protein that interacts with other proteins. In adults, the encoded protein is expressed most highly in retina. Consequently, defects in this gene have been associated with familial exudative vitreoretinopathy (FEVR) and retinitis pigmentosa (RP). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of chemokine secretion (GO:0090197)4.73255965
2regulation of chemokine secretion (GO:0090196)4.71791736
3nucleotide salvage (GO:0043173)4.47669669
4tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.27067422
5RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.27067422
6pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.97196149
7purine nucleotide salvage (GO:0032261)3.96702557
8pentose metabolic process (GO:0019321)3.81053249
9negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.79111350
10polyamine biosynthetic process (GO:0006596)3.74566291
11cellular response to interleukin-4 (GO:0071353)3.73500375
12protein maturation by protein folding (GO:0022417)3.66044765
13negative regulation of macrophage differentiation (GO:0045650)3.57784241
14purine ribonucleotide transport (GO:0015868)3.51618465
15UV protection (GO:0009650)3.50487669
16adenine nucleotide transport (GO:0051503)3.49325569
17negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.45428712
18negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.43679340
19regulation of retinoic acid receptor signaling pathway (GO:0048385)3.34834715
20protein kinase C signaling (GO:0070528)3.27646545
21response to interleukin-4 (GO:0070670)3.22936471
22pyrimidine nucleotide catabolic process (GO:0006244)3.18056605
23regulation of gonadotropin secretion (GO:0032276)3.13574891
24GDP-mannose metabolic process (GO:0019673)3.07538820
25spliceosomal tri-snRNP complex assembly (GO:0000244)3.06065084
26formation of translation preinitiation complex (GO:0001731)3.02287287
27deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.02197231
28negative regulation of Notch signaling pathway (GO:0045746)2.99349258
29ribosome biogenesis (GO:0042254)2.95346372
30hemoglobin metabolic process (GO:0020027)2.94251716
31negative regulation of mRNA metabolic process (GO:1903312)2.90799292
32response to peptidoglycan (GO:0032494)2.83581651
33modulation by virus of host process (GO:0019054)2.81303058
34negative regulation of mRNA processing (GO:0050686)2.80957344
35activation of MAPKKK activity (GO:0000185)2.79286986
36negative regulation of necroptotic process (GO:0060546)2.77730209
37pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.74990465
38positive regulation of macrophage activation (GO:0043032)2.73726913
39positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.73322793
40negative regulation of interferon-gamma production (GO:0032689)2.70215040
41phosphatidylglycerol biosynthetic process (GO:0006655)2.68482163
42regulation of mammary gland epithelial cell proliferation (GO:0033599)2.66929893
43histone H4-K8 acetylation (GO:0043982)2.65029061
44histone H4-K5 acetylation (GO:0043981)2.65029061
45peptidyl-arginine omega-N-methylation (GO:0035247)2.64978495
46purine nucleotide transport (GO:0015865)2.64934638
47nucleoside salvage (GO:0043174)2.62263372
48negative regulation of myeloid cell apoptotic process (GO:0033033)2.61496538
49polyamine metabolic process (GO:0006595)2.59997784
50pentose-phosphate shunt (GO:0006098)2.58883512
51regulation of cytokine secretion involved in immune response (GO:0002739)2.58134397
52pyrimidine nucleoside salvage (GO:0043097)2.57855438
53pyrimidine-containing compound salvage (GO:0008655)2.57855438
54peptidyl-histidine modification (GO:0018202)2.57305041
55regulation of mitochondrial translation (GO:0070129)2.55318527
56negative regulation of DNA-templated transcription, elongation (GO:0032785)2.54770096
57regulation of double-strand break repair via homologous recombination (GO:0010569)2.53119311
58modulation by symbiont of host cellular process (GO:0044068)2.52782416
59viral mRNA export from host cell nucleus (GO:0046784)2.50690931
60cellular metabolic compound salvage (GO:0043094)2.50319498
61regulation of translation in response to stress (GO:0043555)2.49993271
62snRNA metabolic process (GO:0016073)2.49425713
63NIK/NF-kappaB signaling (GO:0038061)2.48663963
64negative regulation of defense response to virus (GO:0050687)2.48572900
65viral protein processing (GO:0019082)2.48106621
66guanosine-containing compound biosynthetic process (GO:1901070)2.47600217
67rRNA modification (GO:0000154)2.47504207
68tRNA methylation (GO:0030488)2.44406265
69tRNA modification (GO:0006400)2.44081255
70histone arginine methylation (GO:0034969)2.43883789
71proline biosynthetic process (GO:0006561)2.43793278
72metallo-sulfur cluster assembly (GO:0031163)2.43443318
73iron-sulfur cluster assembly (GO:0016226)2.43443318
74eyelid development in camera-type eye (GO:0061029)2.43200591
75deoxyribonucleotide catabolic process (GO:0009264)2.43146543
76NADPH regeneration (GO:0006740)2.42880733
77folic acid-containing compound biosynthetic process (GO:0009396)2.42765828
78germinal center formation (GO:0002467)2.42733595
79base-excision repair, AP site formation (GO:0006285)2.42545394
80regulation of macrophage differentiation (GO:0045649)2.40696284
81regulation of interleukin-5 production (GO:0032674)2.40689112
82negative regulation of RNA splicing (GO:0033119)2.40276162
83folic acid metabolic process (GO:0046655)2.40237782
84spliceosomal snRNP assembly (GO:0000387)2.38210871
85ribonucleoprotein complex biogenesis (GO:0022613)2.37927161
86GMP metabolic process (GO:0046037)2.36980326
87proteasome assembly (GO:0043248)2.36960124
88negative regulation of B cell apoptotic process (GO:0002903)2.35352408
89microtubule severing (GO:0051013)2.33592811
90tricarboxylic acid metabolic process (GO:0072350)2.32988256
91telomere maintenance via semi-conservative replication (GO:0032201)2.32912785
92zinc ion transmembrane transport (GO:0071577)2.32856951
93rRNA transcription (GO:0009303)2.32609616
94cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.31684295
95regulation of translational fidelity (GO:0006450)2.30896350
96peptidyl-arginine N-methylation (GO:0035246)2.29350073
97peptidyl-arginine methylation (GO:0018216)2.29350073
98deoxyribose phosphate catabolic process (GO:0046386)2.29166207
99activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.29112627
100negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.28661041

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.32118684
2JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.72795877
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.69467612
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.66564706
5VDR_21846776_ChIP-Seq_THP-1_Human2.40289069
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.34125715
7* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.32038385
8E2F7_22180533_ChIP-Seq_HELA_Human2.28700126
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.28262026
10MYC_22102868_ChIP-Seq_BL_Human2.25431064
11* ETS1_20019798_ChIP-Seq_JURKAT_Human2.25120795
12* GABP_17652178_ChIP-ChIP_JURKAT_Human2.20841848
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.14486941
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.09900219
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.09191361
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.07906788
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.07637886
18GABP_19822575_ChIP-Seq_HepG2_Human2.01052605
19XRN2_22483619_ChIP-Seq_HELA_Human1.94270728
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.87218417
21CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.82733206
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.78359887
23DCP1A_22483619_ChIP-Seq_HELA_Human1.76612252
24ELK3_25401928_ChIP-Seq_HUVEC_Human1.75953048
25DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.74521903
26* EST1_17652178_ChIP-ChIP_JURKAT_Human1.72460247
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.72039317
28* FOXP3_21729870_ChIP-Seq_TREG_Human1.71385023
29MYC_19030024_ChIP-ChIP_MESCs_Mouse1.65363574
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.63357297
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.62765840
32* KDM5A_27292631_Chip-Seq_BREAST_Human1.61177014
33CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.61112974
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.60569216
35CIITA_25753668_ChIP-Seq_RAJI_Human1.60416986
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.59142947
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.58235699
38CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.58124928
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55966288
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.54318392
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53244740
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.52883957
43HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.52064443
44CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.49477814
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.48517554
46MYC_19079543_ChIP-ChIP_MESCs_Mouse1.48498215
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.47964472
48ELF1_20517297_ChIP-Seq_JURKAT_Human1.47274787
49LXR_22292898_ChIP-Seq_THP-1_Human1.43698259
50KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42612311
51SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.41993447
52E2F1_18555785_ChIP-Seq_MESCs_Mouse1.41749392
53CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.39609982
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37777289
55BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.37330182
56* VDR_23849224_ChIP-Seq_CD4+_Human1.37240953
57MAF_26560356_Chip-Seq_TH2_Human1.36257758
58TET1_21451524_ChIP-Seq_MESCs_Mouse1.35921841
59TFEB_21752829_ChIP-Seq_HELA_Human1.30269490
60RACK7_27058665_Chip-Seq_MCF-7_Human1.28055257
61MAF_26560356_Chip-Seq_TH1_Human1.27116510
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26889134
63ZNF263_19887448_ChIP-Seq_K562_Human1.26860779
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26567937
65TTF2_22483619_ChIP-Seq_HELA_Human1.26443751
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.24339341
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.22722822
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21554871
69BCOR_27268052_Chip-Seq_Bcells_Human1.21172838
70CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18616081
71SPI1_23547873_ChIP-Seq_NB4_Human1.18601488
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16165309
73BCL6_27268052_Chip-Seq_Bcells_Human1.15160572
74MYCN_18555785_ChIP-Seq_MESCs_Mouse1.15091419
75RARG_19884340_ChIP-ChIP_MEFs_Mouse1.14758243
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14051383
77UTX_26944678_Chip-Seq_JUKART_Human1.13185354
78MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.12746949
79* P68_20966046_ChIP-Seq_HELA_Human1.11301660
80SRF_21415370_ChIP-Seq_HL-1_Mouse1.10936281
81VDR_24763502_ChIP-Seq_THP-1_Human1.10166587
82NANOG_18555785_ChIP-Seq_MESCs_Mouse1.09149538
83ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.08660068
84IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.08618088
85CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06943307
86* SA1_27219007_Chip-Seq_ERYTHROID_Human1.06225592
87CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06170202
88GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06031891
89MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05585999
90CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05527805
91* FOXP1_21924763_ChIP-Seq_HESCs_Human1.05196155
92PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05109190
93STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05071253
94KDM2B_26808549_Chip-Seq_DND41_Human1.04517708
95E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04072448
96NCOR1_26117541_ChIP-Seq_K562_Human1.03970970
97GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03432218
98E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.03424897
99TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03275130
100BP1_19119308_ChIP-ChIP_Hs578T_Human1.03032238

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009278_abnormal_bone_marrow3.34153929
2MP0005451_abnormal_body_composition3.31283822
3MP0002132_abnormal_respiratory_system3.17769373
4MP0005360_urolithiasis3.16825552
5MP0005058_abnormal_lysosome_morphology3.16383876
6MP0003315_abnormal_perineum_morphology3.02596404
7MP0002653_abnormal_ependyma_morphology2.97149464
8MP0009840_abnormal_foam_cell2.83688103
9MP0005670_abnormal_white_adipose2.72466751
10MP0003693_abnormal_embryo_hatching2.42685608
11MP0003300_gastrointestinal_ulcer2.33856872
12MP0002148_abnormal_hypersensitivity_rea2.21816530
13MP0003806_abnormal_nucleotide_metabolis2.20663381
14MP0005397_hematopoietic_system_phenotyp2.13642473
15MP0001545_abnormal_hematopoietic_system2.13642473
16MP0008058_abnormal_DNA_repair2.10227884
17MP0003191_abnormal_cellular_cholesterol1.89642229
18MP0003111_abnormal_nucleus_morphology1.77692755
19MP0003186_abnormal_redox_activity1.77201832
20MP0002138_abnormal_hepatobiliary_system1.74935273
21MP0009333_abnormal_splenocyte_physiolog1.74507895
22MP0002163_abnormal_gland_morphology1.73107787
23MP0002254_reproductive_system_inflammat1.67782758
24MP0005501_abnormal_skin_physiology1.64908009
25MP0002796_impaired_skin_barrier1.56987179
26MP0001270_distended_abdomen1.56081934
27MP0003436_decreased_susceptibility_to1.53208026
28MP0002396_abnormal_hematopoietic_system1.49364447
29MP0009764_decreased_sensitivity_to1.45552690
30MP0006035_abnormal_mitochondrial_morpho1.38470461
31MP0005025_abnormal_response_to1.33907586
32MP0004264_abnormal_extraembryonic_tissu1.30066448
33MP0002098_abnormal_vibrissa_morphology1.28976719
34MP0002723_abnormal_immune_serum1.28169795
35MP0005000_abnormal_immune_tolerance1.27796491
36MP0002009_preneoplasia1.25896594
37MP0002089_abnormal_postnatal_growth/wei1.24983081
38MP0002452_abnormal_antigen_presenting1.23936227
39MP0002419_abnormal_innate_immunity1.20253926
40MP0003303_peritoneal_inflammation1.19124282
41MP0003763_abnormal_thymus_physiology1.18647145
42MP0005187_abnormal_penis_morphology1.18263489
43MP0010307_abnormal_tumor_latency1.17857460
44MP0002398_abnormal_bone_marrow1.17346643
45MP0002277_abnormal_respiratory_mucosa1.16582442
46MP0000538_abnormal_urinary_bladder1.16160578
47MP0001800_abnormal_humoral_immune1.15323502
48MP0000689_abnormal_spleen_morphology1.14789177
49MP0002420_abnormal_adaptive_immunity1.13849074
50MP0004233_abnormal_muscle_weight1.12946521
51MP0001819_abnormal_immune_cell1.12920707
52MP0003724_increased_susceptibility_to1.10276581
53MP0008469_abnormal_protein_level1.07877367
54MP0010094_abnormal_chromosome_stability1.07762687
55MP0003123_paternal_imprinting1.07506631
56MP0003786_premature_aging1.06662216
57MP0000343_altered_response_to1.06514509
58MP0005464_abnormal_platelet_physiology1.06385330
59MP0001845_abnormal_inflammatory_respons1.06300489
60MP0000490_abnormal_crypts_of1.06086851
61MP0002429_abnormal_blood_cell1.05531857
62MP0004957_abnormal_blastocyst_morpholog1.05074393
63MP0002722_abnormal_immune_system1.05067444
64MP0008260_abnormal_autophagy1.04224276
65MP0009785_altered_susceptibility_to1.03512770
66MP0000358_abnormal_cell_content/1.02942588
67MP0005645_abnormal_hypothalamus_physiol1.02577023
68MP0000858_altered_metastatic_potential0.99094602
69MP0003172_abnormal_lysosome_physiology0.99075585
70MP0005076_abnormal_cell_differentiation0.98969996
71MP0001764_abnormal_homeostasis0.98392646
72MP0000716_abnormal_immune_system0.97471125
73MP0003077_abnormal_cell_cycle0.97074318
74MP0002019_abnormal_tumor_incidence0.94007574
75MP0005387_immune_system_phenotype0.93060182
76MP0001790_abnormal_immune_system0.93060182
77MP0004808_abnormal_hematopoietic_stem0.90337207
78MP0008877_abnormal_DNA_methylation0.89989807
79MP0006036_abnormal_mitochondrial_physio0.87595619
80MP0000313_abnormal_cell_death0.86723272
81MP0005319_abnormal_enzyme/_coenzyme0.86171997
82MP0008932_abnormal_embryonic_tissue0.84195176
83MP0000703_abnormal_thymus_morphology0.80860305
84MP0005365_abnormal_bile_salt0.78341705
85MP0001835_abnormal_antigen_presentation0.75948748
86MP0005671_abnormal_response_to0.75400822
87MP0003453_abnormal_keratinocyte_physiol0.74369090
88MP0008873_increased_physiological_sensi0.74038633
89MP0000003_abnormal_adipose_tissue0.73502381
90MP0010352_gastrointestinal_tract_polyps0.73311214
91MP0000598_abnormal_liver_morphology0.71894932
92MP0000537_abnormal_urethra_morphology0.71038470
93MP0000467_abnormal_esophagus_morphology0.70528888
94MP0000685_abnormal_immune_system0.69101267
95MP0000678_abnormal_parathyroid_gland0.67605385
96MP0001853_heart_inflammation0.67461967
97MP0010155_abnormal_intestine_physiology0.67413875
98MP0008004_abnormal_stomach_pH0.65205576
99MP0002210_abnormal_sex_determination0.65199259
100MP0001730_embryonic_growth_arrest0.64846807

Predicted human phenotypes

RankGene SetZ-score
1Azoospermia (HP:0000027)4.27787502
2Petechiae (HP:0000967)3.54458551
3Abnormal spermatogenesis (HP:0008669)3.36196911
4Increased neuronal autofluorescent lipopigment (HP:0002074)3.27192441
5Increased cerebral lipofuscin (HP:0011813)3.24685881
6Abnormality of glycolipid metabolism (HP:0010969)3.07388015
7Abnormality of liposaccharide metabolism (HP:0010968)3.07388015
8Abnormality of glycosphingolipid metabolism (HP:0004343)3.07388015
9Prolonged neonatal jaundice (HP:0006579)2.94507898
10Hypertensive crisis (HP:0100735)2.91143935
11Abnormal gallbladder physiology (HP:0012438)2.87722365
12Cholecystitis (HP:0001082)2.87722365
13Progressive microcephaly (HP:0000253)2.81851315
14Long palpebral fissure (HP:0000637)2.80876184
15Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.74126404
16Testicular atrophy (HP:0000029)2.69365978
17Loss of speech (HP:0002371)2.67695079
18Microvesicular hepatic steatosis (HP:0001414)2.67211869
19Abnormal glycosylation (HP:0012345)2.67157832
20Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.67157832
21Abnormal protein N-linked glycosylation (HP:0012347)2.67157832
22Abnormal protein glycosylation (HP:0012346)2.67157832
23Nonimmune hydrops fetalis (HP:0001790)2.64414071
24Premature ovarian failure (HP:0008209)2.49157121
25Nausea (HP:0002018)2.43398956
26Hypokinesia (HP:0002375)2.43243032
27Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.41738096
28Progressive muscle weakness (HP:0003323)2.41338029
29Ragged-red muscle fibers (HP:0003200)2.37146783
30Microretrognathia (HP:0000308)2.33590328
31Hypoplasia of the capital femoral epiphysis (HP:0003090)2.33000009
32Cellulitis (HP:0100658)2.31271716
33Stomatitis (HP:0010280)2.29726054
34Purpura (HP:0000979)2.28735716
35Elevated erythrocyte sedimentation rate (HP:0003565)2.27721413
36Hepatosplenomegaly (HP:0001433)2.26585018
37Vacuolated lymphocytes (HP:0001922)2.19656922
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.19098716
39Myopathic facies (HP:0002058)2.19036714
40Increased serum ferritin (HP:0003281)2.16434694
41Prostate neoplasm (HP:0100787)2.15045220
42J-shaped sella turcica (HP:0002680)2.14377885
43Deformed sella turcica (HP:0002681)2.11839524
44Fatigue (HP:0012378)2.11471308
45Hemorrhage of the eye (HP:0011885)2.11440502
46Anorexia (HP:0002039)2.09675398
47Hand muscle atrophy (HP:0009130)2.06775050
48Thrombocytosis (HP:0001894)2.06175299
49Flattened epiphyses (HP:0003071)2.05529053
50Abnormality of the heme biosynthetic pathway (HP:0010472)2.04618860
51Progressive external ophthalmoplegia (HP:0000590)2.04202529
52Vertebral compression fractures (HP:0002953)1.98274213
53Chronic obstructive pulmonary disease (HP:0006510)1.97862597
54Obstructive lung disease (HP:0006536)1.97862597
55Small epiphyses (HP:0010585)1.97188511
56Abnormal umbilical cord blood vessels (HP:0011403)1.96816493
57Single umbilical artery (HP:0001195)1.96816493
58Abnormality of the fetal cardiovascular system (HP:0010948)1.96816493
59Abnormality of macrophages (HP:0004311)1.96322297
60Squamous cell carcinoma (HP:0002860)1.95507100
61Upper limb amyotrophy (HP:0009129)1.95167591
62Distal upper limb amyotrophy (HP:0007149)1.95167591
63Abnormal number of erythroid precursors (HP:0012131)1.94882610
64Spastic paraparesis (HP:0002313)1.94329221
65Diaphragmatic weakness (HP:0009113)1.93411919
66Mediastinal lymphadenopathy (HP:0100721)1.93327615
67Increased muscle lipid content (HP:0009058)1.91608087
68Abnormal mitochondria in muscle tissue (HP:0008316)1.88501576
69Broad distal phalanx of finger (HP:0009836)1.87885331
70Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.87402957
71Recurrent abscess formation (HP:0002722)1.86877241
72Type I transferrin isoform profile (HP:0003642)1.86039839
73Depressed nasal tip (HP:0000437)1.85196382
74Myositis (HP:0100614)1.85084452
75Recurrent bacterial skin infections (HP:0005406)1.84335065
76Aplastic anemia (HP:0001915)1.84306561
77Erythema (HP:0010783)1.83728086
78Aplasia/Hypoplasia of the sacrum (HP:0008517)1.83080078
79Dicarboxylic aciduria (HP:0003215)1.82626368
80Abnormality of dicarboxylic acid metabolism (HP:0010995)1.82626368
81Trismus (HP:0000211)1.82504480
82Pancytopenia (HP:0001876)1.82257037
83Abnormality of the umbilical cord (HP:0010881)1.82138135
84Secondary amenorrhea (HP:0000869)1.81926962
85Carpal bone hypoplasia (HP:0001498)1.80929753
86Decreased activity of mitochondrial respiratory chain (HP:0008972)1.80009295
87Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.80009295
88Congenital ichthyosiform erythroderma (HP:0007431)1.79584504
89Epistaxis (HP:0000421)1.79369457
90Abnormal number of incisors (HP:0011064)1.78253893
91Gastrointestinal infarctions (HP:0005244)1.78200534
92Entropion (HP:0000621)1.78155428
93Dysostosis multiplex (HP:0000943)1.78018627
94Brushfield spots (HP:0001088)1.76871013
95Increased intramyocellular lipid droplets (HP:0012240)1.76714983
96Broad face (HP:0000283)1.76396599
97Polygenic inheritance (HP:0010982)1.71434843
98Mitral stenosis (HP:0001718)1.71297711
99Methylmalonic aciduria (HP:0012120)1.70366896
100Poor eye contact (HP:0000817)1.68443940

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK24.09284735
2NME23.41547735
3TESK23.36610804
4ERN12.94765201
5SMG12.73083982
6BCKDK2.60348773
7PIM22.51546032
8IRAK32.49939629
9TNK22.12187947
10CLK12.10054430
11PRPF4B2.08641831
12VRK21.99995754
13STK161.98743643
14TAOK21.94859335
15SIK11.94733657
16ZAK1.69412341
17IRAK41.62156793
18TESK11.59077189
19MAP3K111.59031078
20IKBKB1.58862510
21MAP3K31.58343435
22MAP2K31.54615241
23IRAK21.52072961
24AURKA1.50151944
25CDK91.48028315
26TRIB31.46145604
27CDK71.45091665
28TLK11.42986886
29BUB11.42765583
30MAP4K11.39541241
31TBK11.38991645
32EPHA21.37419530
33ICK1.31852792
34STK41.29899604
35MAP3K11.27864819
36MAPK111.17707663
37TAOK11.12769723
38MAP3K81.11017376
39PRKG21.10605949
40JAK31.05883919
41SIK21.03290618
42KDR1.00920493
43PAK41.00343227
44CDK40.97132313
45IKBKE0.96117300
46DYRK30.95976399
47PASK0.94474294
48ABL20.92321693
49CDK190.86877451
50SCYL20.86495765
51MAP3K100.83074825
52EPHB10.82449059
53CDK80.81472288
54DYRK1B0.80501724
55LIMK10.77867633
56STK100.77750743
57CDK120.76935634
58PRKCI0.76880651
59TAOK30.74151357
60RPS6KA50.71088738
61MAP2K70.70391943
62PDK20.69584700
63CHEK20.68987381
64PIM10.68520036
65GRK60.67991293
66SRPK10.65988394
67RIPK40.64296064
68ATR0.63485546
69SIK30.59854607
70RPS6KB20.55762968
71PDPK10.55184709
72PRKD20.54827189
73PAK10.54380401
74FER0.53618908
75TYK20.53013327
76LRRK20.51443794
77VRK10.50285678
78BMPR20.50241466
79CHEK10.50184468
80MAP3K140.49622452
81AURKB0.48949972
82IRAK10.48195625
83MTOR0.48040448
84FGFR40.47461596
85CHUK0.45930065
86FGR0.44757607
87PRKCQ0.44490184
88BRD40.42834742
89CSNK1G30.41377783
90GSK3A0.40203307
91CSK0.37886088
92CSF1R0.36937121
93MATK0.36831278
94DAPK30.36765269
95CDC42BPA0.36348775
96MAP3K50.36280313
97CSNK2A20.35606272
98CAMK2G0.32513200
99AKT20.32093734
100CSNK2A10.31577156

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.32784883
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.24720373
3Base excision repair_Homo sapiens_hsa034103.12206117
4Other glycan degradation_Homo sapiens_hsa005112.48416360
5Proteasome_Homo sapiens_hsa030502.24140227
6Spliceosome_Homo sapiens_hsa030402.09112182
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.99690267
8Sulfur relay system_Homo sapiens_hsa041221.97013991
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.94758155
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.94051397
11Pyrimidine metabolism_Homo sapiens_hsa002401.84676105
12Ribosome_Homo sapiens_hsa030101.84087242
13Mismatch repair_Homo sapiens_hsa034301.83175083
14RNA transport_Homo sapiens_hsa030131.77033956
15Fatty acid elongation_Homo sapiens_hsa000621.72375682
16Galactose metabolism_Homo sapiens_hsa000521.69331871
17Folate biosynthesis_Homo sapiens_hsa007901.68712913
18SNARE interactions in vesicular transport_Homo sapiens_hsa041301.66569265
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.64396344
20Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.62251477
21Bladder cancer_Homo sapiens_hsa052191.60259807
22Pentose phosphate pathway_Homo sapiens_hsa000301.60028690
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.58398741
24RNA polymerase_Homo sapiens_hsa030201.57213894
25Lysosome_Homo sapiens_hsa041421.54256783
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.50560536
27Nucleotide excision repair_Homo sapiens_hsa034201.49099415
28Vibrio cholerae infection_Homo sapiens_hsa051101.46877553
29Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.45898625
30Biosynthesis of amino acids_Homo sapiens_hsa012301.44739637
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.44667486
32Regulation of autophagy_Homo sapiens_hsa041401.41661724
33N-Glycan biosynthesis_Homo sapiens_hsa005101.30902196
34Primary immunodeficiency_Homo sapiens_hsa053401.23645030
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19678243
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.17570846
37Homologous recombination_Homo sapiens_hsa034401.16968413
38Collecting duct acid secretion_Homo sapiens_hsa049661.14705347
39Carbon metabolism_Homo sapiens_hsa012001.10541110
40One carbon pool by folate_Homo sapiens_hsa006701.07049311
41Acute myeloid leukemia_Homo sapiens_hsa052211.05394547
42Glutathione metabolism_Homo sapiens_hsa004801.04954603
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.03637085
44Sulfur metabolism_Homo sapiens_hsa009201.02777575
45Systemic lupus erythematosus_Homo sapiens_hsa053221.01873786
46Shigellosis_Homo sapiens_hsa051311.01479437
47mRNA surveillance pathway_Homo sapiens_hsa030150.98290574
48Fructose and mannose metabolism_Homo sapiens_hsa000510.95837523
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.91916706
50Herpes simplex infection_Homo sapiens_hsa051680.91904910
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88836266
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84359319
53Cell cycle_Homo sapiens_hsa041100.83965870
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82221693
55Apoptosis_Homo sapiens_hsa042100.81999743
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80986772
57Legionellosis_Homo sapiens_hsa051340.79648703
58Basal transcription factors_Homo sapiens_hsa030220.79438769
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78364146
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.77078712
61Sphingolipid metabolism_Homo sapiens_hsa006000.76285131
62Phenylalanine metabolism_Homo sapiens_hsa003600.75554088
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.74186309
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73804923
65Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73755121
66p53 signaling pathway_Homo sapiens_hsa041150.73442777
67Epstein-Barr virus infection_Homo sapiens_hsa051690.73320854
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71774243
69Viral carcinogenesis_Homo sapiens_hsa052030.71305243
70Purine metabolism_Homo sapiens_hsa002300.68443976
71HTLV-I infection_Homo sapiens_hsa051660.64856201
72Oxidative phosphorylation_Homo sapiens_hsa001900.64780032
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63617829
74Toll-like receptor signaling pathway_Homo sapiens_hsa046200.63005687
75Arginine and proline metabolism_Homo sapiens_hsa003300.62120620
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61575247
77Hepatitis B_Homo sapiens_hsa051610.60834568
78Tuberculosis_Homo sapiens_hsa051520.57572747
79Salmonella infection_Homo sapiens_hsa051320.56338053
80Parkinsons disease_Homo sapiens_hsa050120.54817095
81Metabolic pathways_Homo sapiens_hsa011000.53178999
82Phagosome_Homo sapiens_hsa041450.52226822
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51723846
84Osteoclast differentiation_Homo sapiens_hsa043800.50531412
85Non-homologous end-joining_Homo sapiens_hsa034500.49317152
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48741142
87Notch signaling pathway_Homo sapiens_hsa043300.47253871
88Rheumatoid arthritis_Homo sapiens_hsa053230.47158098
89Measles_Homo sapiens_hsa051620.46853688
90Huntingtons disease_Homo sapiens_hsa050160.45743890
91RNA degradation_Homo sapiens_hsa030180.45363991
92Selenocompound metabolism_Homo sapiens_hsa004500.45285931
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45015273
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44478137
95Leishmaniasis_Homo sapiens_hsa051400.43210146
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43170263
97Fanconi anemia pathway_Homo sapiens_hsa034600.42734258
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39475198
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39298941
100Peroxisome_Homo sapiens_hsa041460.38070467

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