ZNF41

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that contains KRAB-A and KRAB-B domains multiple zinc finger DNA binding motifs and finger linking regions characteristic of the Kruppel family. An initial study suggested that this gene may be associated with X-linked mental retardation, but a later study has called this finding into question (PMID:23871722). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)6.61183361
2muscle filament sliding (GO:0030049)6.61183361
3sarcoplasmic reticulum calcium ion transport (GO:0070296)5.71274229
4actin-mediated cell contraction (GO:0070252)5.57981061
5skeletal muscle contraction (GO:0003009)5.33023595
6sarcomere organization (GO:0045214)4.88921925
7regulation of relaxation of muscle (GO:1901077)4.78749155
8actin filament-based movement (GO:0030048)4.72734158
9response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.32587615
10skeletal muscle adaptation (GO:0043501)4.31716841
11myofibril assembly (GO:0030239)4.17653822
12cellular extravasation (GO:0045123)4.07216311
13striated muscle contraction (GO:0006941)4.05286826
14negative regulation of necroptotic process (GO:0060546)4.01344178
15nuclear pore complex assembly (GO:0051292)3.90987396
16regulation of necroptotic process (GO:0060544)3.88464960
17endoplasmic reticulum organization (GO:0007029)3.87107642
18positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.85766986
19N-terminal protein amino acid acetylation (GO:0006474)3.81209961
20COPI coating of Golgi vesicle (GO:0048205)3.74799973
21Golgi transport vesicle coating (GO:0048200)3.74799973
22fibroblast migration (GO:0010761)3.70888326
23regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.60838733
24actomyosin structure organization (GO:0031032)3.47842101
25cardiac myofibril assembly (GO:0055003)3.46721774
26COPII vesicle coating (GO:0048208)3.45830546
27motile cilium assembly (GO:0044458)3.44163209
28regulation of skeletal muscle contraction (GO:0014819)3.44101120
29regulation of NFAT protein import into nucleus (GO:0051532)3.41378881
30striated muscle atrophy (GO:0014891)3.41353966
31response to inactivity (GO:0014854)3.41093258
32response to muscle activity (GO:0014850)3.39513445
33positive regulation of myotube differentiation (GO:0010831)3.39224503
34cardiac muscle hypertrophy (GO:0003300)3.37825818
35phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.34223407
36positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.32377409
37cardiac muscle contraction (GO:0060048)3.32061503
38negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.23046820
39striated muscle hypertrophy (GO:0014897)3.20582022
40striated muscle adaptation (GO:0014888)3.20345260
41succinate metabolic process (GO:0006105)3.20184136
42response to epinephrine (GO:0071871)3.17642007
43regulation of actin filament-based movement (GO:1903115)3.13442119
44histone H3-K36 demethylation (GO:0070544)3.12016973
45glycogen catabolic process (GO:0005980)3.11437483
46regulation of cell communication by electrical coupling (GO:0010649)3.09401519
47negative regulation of necrotic cell death (GO:0060547)3.09170554
48glucan catabolic process (GO:0009251)3.02349211
49vesicle transport along microtubule (GO:0047496)2.99035778
50muscle cell cellular homeostasis (GO:0046716)2.98596387
51nuclear pore organization (GO:0006999)2.98409893
52coronary vasculature morphogenesis (GO:0060977)2.95958781
53retrograde transport, vesicle recycling within Golgi (GO:0000301)2.95212066
54carnitine shuttle (GO:0006853)2.92500584
55cellular polysaccharide catabolic process (GO:0044247)2.91640657
56vesicle coating (GO:0006901)2.91224938
57muscle atrophy (GO:0014889)2.90448491
58protein targeting to Golgi (GO:0000042)2.85309198
59mitochondrion distribution (GO:0048311)2.84389224
60retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.84330399
61regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.83344266
62pore complex assembly (GO:0046931)2.81901372
63regulation of skeletal muscle cell differentiation (GO:2001014)2.81060445
64dosage compensation (GO:0007549)2.78472532
65muscle contraction (GO:0006936)2.76248279
66establishment of protein localization to Golgi (GO:0072600)2.76109956
67regulation of Golgi to plasma membrane protein transport (GO:0042996)2.75222953
68regulation of acyl-CoA biosynthetic process (GO:0050812)2.72850064
69germinal center formation (GO:0002467)2.72459835
70positive regulation of developmental pigmentation (GO:0048087)2.70485314
71DNA methylation involved in gamete generation (GO:0043046)2.68139534
72muscle hypertrophy (GO:0014896)2.67508831
73regulation of pigment cell differentiation (GO:0050932)2.67390547
74skeletal muscle tissue development (GO:0007519)2.66646363
75negative regulation of potassium ion transmembrane transport (GO:1901380)2.65919096
76regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.63096128
77peptidyl-lysine dimethylation (GO:0018027)2.62780105
78negative regulation of protein oligomerization (GO:0032460)2.61533141
79skeletal muscle fiber development (GO:0048741)2.60496702
80protein localization to Golgi apparatus (GO:0034067)2.58311588
81polysaccharide catabolic process (GO:0000272)2.53833960
82negative regulation of glycoprotein biosynthetic process (GO:0010561)2.53220436
83regulation of protein polyubiquitination (GO:1902914)2.51204873
84neutrophil mediated immunity (GO:0002446)2.50949283
85positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.50272390
86cellular response to epinephrine stimulus (GO:0071872)2.50258398
87protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.49875758
88regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.49419992
89glucocorticoid receptor signaling pathway (GO:0042921)2.48263658
90negative regulation of cell killing (GO:0031342)2.47934591
91negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.47934591
92plasma membrane repair (GO:0001778)2.47865358
93cardiac muscle adaptation (GO:0014887)2.45816514
94cardiac muscle hypertrophy in response to stress (GO:0014898)2.45816514
95muscle hypertrophy in response to stress (GO:0003299)2.45816514
96regulation of cofactor metabolic process (GO:0051193)2.45741989
97regulation of coenzyme metabolic process (GO:0051196)2.45741989
98histone H3-K9 demethylation (GO:0033169)2.45295274
99regulation of sequestering of triglyceride (GO:0010889)2.44894018
100response to laminar fluid shear stress (GO:0034616)2.44246894

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SMAD_19615063_ChIP-ChIP_OVARY_Human4.51654960
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.37200355
3RBPJ_22232070_ChIP-Seq_NCS_Mouse4.02879056
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.35146132
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.23237436
6ESR1_20079471_ChIP-ChIP_T-47D_Human2.71635344
7AR_21572438_ChIP-Seq_LNCaP_Human2.59074269
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.47558935
9WT1_19549856_ChIP-ChIP_CCG9911_Human2.39617346
10RUNX_20019798_ChIP-Seq_JUKART_Human2.27073739
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.19743257
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12089233
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.02816917
14CDX2_19796622_ChIP-Seq_MESCs_Mouse2.01531975
15MYB_21317192_ChIP-Seq_ERMYB_Mouse1.99390206
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.94189626
17POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91665967
18KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.90834511
19FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.90024505
20BP1_19119308_ChIP-ChIP_Hs578T_Human1.89810658
21GATA4_21415370_ChIP-Seq_HL-1_Mouse1.89153098
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.89104316
23TBX20_22328084_ChIP-Seq_HEART_Mouse1.86062899
24TBX20_22080862_ChIP-Seq_HEART_Mouse1.86062899
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81854733
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.81401779
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.81171353
28TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77926604
29ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.75140686
30PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.68613718
31GATA1_22025678_ChIP-Seq_K562_Human1.59818132
32IGF1R_20145208_ChIP-Seq_DFB_Human1.59065348
33PU_27001747_Chip-Seq_BMDM_Mouse1.56997759
34TFEB_21752829_ChIP-Seq_HELA_Human1.51860895
35EP300_21415370_ChIP-Seq_HL-1_Mouse1.49519541
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48852010
37FUS_26573619_Chip-Seq_HEK293_Human1.47939456
38SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.47263141
39SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.47263141
40NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.45211752
41TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.43446385
42GBX2_23144817_ChIP-Seq_PC3_Human1.41875520
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41298008
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40581860
45BRD4_25478319_ChIP-Seq_HGPS_Human1.39309451
46IRF8_27001747_Chip-Seq_BMDM_Mouse1.37227219
47ELK1_19687146_ChIP-ChIP_HELA_Human1.33935934
48TCF4_18268006_ChIP-ChIP_LS174T_Human1.32568388
49NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.27314597
50NRF2_20460467_ChIP-Seq_MEFs_Mouse1.27314597
51CLOCK_20551151_ChIP-Seq_293T_Human1.27082779
52ER_23166858_ChIP-Seq_MCF-7_Human1.26976296
53ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26240204
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26149064
55SALL4_18804426_ChIP-ChIP_XEN_Mouse1.25682653
56CTNNB1_20460455_ChIP-Seq_HCT116_Human1.25540114
57CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.24425411
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24396475
59NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.23183207
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22652913
61MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.22627788
62SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.21418898
63GATA2_21666600_ChIP-Seq_HMVEC_Human1.19397841
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17127728
65CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16693417
66SPI1_23127762_ChIP-Seq_K562_Human1.16165926
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14591838
68CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13789255
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13439375
70ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12971265
71ELK4_26923725_Chip-Seq_MESODERM_Mouse1.12733308
72BRD4_27068464_Chip-Seq_AML-cells_Mouse1.12406977
73* SPI1_23547873_ChIP-Seq_NB4_Human1.11991277
74GATA1_19941827_ChIP-Seq_MEL_Mouse1.11463507
75FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11403439
76EGR1_19374776_ChIP-ChIP_THP-1_Human1.10350253
77SCL_19346495_ChIP-Seq_HPC-7_Human1.08699913
78PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.08610617
79FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.07789330
80DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06511983
81HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06088145
82RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.04014650
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03277200
84SALL4_22934838_ChIP-ChIP_CD34+_Human1.02215931
85TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.01775842
86FLI1_21867929_ChIP-Seq_TH2_Mouse0.98834488
87OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98097675
88EZH2_27294783_Chip-Seq_NPCs_Mouse0.98037137
89MYB_26560356_Chip-Seq_TH2_Human0.97952169
90GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96242336
91* CIITA_25753668_ChIP-Seq_RAJI_Human0.96156731
92VDR_24787735_ChIP-Seq_THP-1_Human0.96125809
93TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95718935
94NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94229587
95SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.91144338
96ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91057563
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.89942699
98CJUN_26792858_Chip-Seq_BT549_Human0.89042753
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88978215
100STAT3_23295773_ChIP-Seq_U87_Human0.88580665

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.66979829
2MP0000749_muscle_degeneration4.24197078
3MP0000751_myopathy4.07353913
4MP0004233_abnormal_muscle_weight4.02753715
5MP0005451_abnormal_body_composition3.74000648
6MP0004036_abnormal_muscle_relaxation3.38413797
7MP0002332_abnormal_exercise_endurance3.01148601
8MP0004145_abnormal_muscle_electrophysio2.83133919
9MP0004084_abnormal_cardiac_muscle2.70056274
10MP0000747_muscle_weakness2.65591274
11MP0004130_abnormal_muscle_cell2.60490344
12MP0000759_abnormal_skeletal_muscle2.56023821
13MP0002009_preneoplasia2.51386561
14MP0002837_dystrophic_cardiac_calcinosis2.50168771
15MP0002106_abnormal_muscle_physiology2.47818476
16MP0002269_muscular_atrophy2.43225734
17MP0004087_abnormal_muscle_fiber2.39153325
18MP0000733_abnormal_muscle_development2.17673947
19MP0004484_altered_response_of2.15008730
20MP0005369_muscle_phenotype1.96951284
21MP0003221_abnormal_cardiomyocyte_apopto1.96179079
22MP0000750_abnormal_muscle_regeneration1.95343806
23MP0000013_abnormal_adipose_tissue1.92903917
24MP0005330_cardiomyopathy1.85991793
25MP0003828_pulmonary_edema1.81918172
26MP0010352_gastrointestinal_tract_polyps1.80084426
27MP0009780_abnormal_chondrocyte_physiolo1.65422805
28MP0005620_abnormal_muscle_contractility1.63797158
29MP0003045_fibrosis1.60015096
30MP0004510_myositis1.52600315
31MP0002877_abnormal_melanocyte_morpholog1.50984471
32MP0000569_abnormal_digit_pigmentation1.50683407
33MP0003300_gastrointestinal_ulcer1.50438253
34MP0002166_altered_tumor_susceptibility1.49708964
35MP0002822_catalepsy1.48510365
36MP0002971_abnormal_brown_adipose1.48195411
37MP0010234_abnormal_vibrissa_follicle1.37967303
38MP0002972_abnormal_cardiac_muscle1.34506152
39MP0003656_abnormal_erythrocyte_physiolo1.32888251
40MP0005248_abnormal_Harderian_gland1.28526022
41MP0010630_abnormal_cardiac_muscle1.27698200
42MP0005266_abnormal_metabolism1.26209223
43MP0002396_abnormal_hematopoietic_system1.25873027
44MP0000003_abnormal_adipose_tissue1.17659618
45MP0006036_abnormal_mitochondrial_physio1.15135005
46MP0001727_abnormal_embryo_implantation1.14998369
47MP0001544_abnormal_cardiovascular_syste1.14160944
48MP0005385_cardiovascular_system_phenoty1.14160944
49MP0003763_abnormal_thymus_physiology1.13088900
50MP0003091_abnormal_cell_migration1.12125380
51MP0002108_abnormal_muscle_morphology1.11777679
52MP0006035_abnormal_mitochondrial_morpho1.11182736
53MP0005076_abnormal_cell_differentiation1.06827402
54MP0008260_abnormal_autophagy1.06117426
55MP0000465_gastrointestinal_hemorrhage1.06097050
56MP0001661_extended_life_span1.01862774
57MP0003566_abnormal_cell_adhesion1.01528487
58MP0005171_absent_coat_pigmentation0.99799238
59MP0002006_tumorigenesis0.98681146
60MP0003879_abnormal_hair_cell0.95737964
61MP0003724_increased_susceptibility_to0.89627900
62MP0005375_adipose_tissue_phenotype0.86354011
63MP0004215_abnormal_myocardial_fiber0.82289306
64MP0001851_eye_inflammation0.82131907
65MP0003868_abnormal_feces_composition0.78327084
66MP0009115_abnormal_fat_cell0.77986607
67MP0006138_congestive_heart_failure0.75422145
68MP0008775_abnormal_heart_ventricle0.74682321
69MP0004270_analgesia0.72224087
70MP0008057_abnormal_DNA_replication0.69774680
71MP0002127_abnormal_cardiovascular_syste0.69374751
72MP0003303_peritoneal_inflammation0.68986740
73MP0001915_intracranial_hemorrhage0.67664525
74MP0004381_abnormal_hair_follicle0.66202134
75MP0004185_abnormal_adipocyte_glucose0.65414218
76MP0003385_abnormal_body_wall0.63118681
77MP0005621_abnormal_cell_physiology0.60478045
78MP0008874_decreased_physiological_sensi0.59562794
79MP0005666_abnormal_adipose_tissue0.58615192
80MP0000427_abnormal_hair_cycle0.58255204
81MP0000767_abnormal_smooth_muscle0.54165584
82MP0005376_homeostasis/metabolism_phenot0.53148858
83MP0000703_abnormal_thymus_morphology0.52630135
84MP0000266_abnormal_heart_morphology0.52381697
85MP0005384_cellular_phenotype0.52251086
86MP0009703_decreased_birth_body0.51367170
87MP0005464_abnormal_platelet_physiology0.48905989
88MP0005058_abnormal_lysosome_morphology0.48883012
89MP0004808_abnormal_hematopoietic_stem0.48808590
90MP0001958_emphysema0.48365740
91MP0010155_abnormal_intestine_physiology0.48149227
92MP0010678_abnormal_skin_adnexa0.47674416
93MP0002722_abnormal_immune_system0.47266347
94MP0003950_abnormal_plasma_membrane0.46207496
95MP0009672_abnormal_birth_weight0.45937688
96MP0004197_abnormal_fetal_growth/weight/0.45779521
97MP0001299_abnormal_eye_distance/0.45501461
98MP0005165_increased_susceptibility_to0.45461089
99MP0002168_other_aberrant_phenotype0.44551507
100MP0003948_abnormal_gas_homeostasis0.43475292

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)7.54560251
2Nemaline bodies (HP:0003798)7.46548597
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.40276066
4Exercise-induced myalgia (HP:0003738)5.66483583
5Type 1 muscle fiber predominance (HP:0003803)5.34384173
6Exercise-induced muscle cramps (HP:0003710)5.11616362
7Difficulty running (HP:0009046)4.87355891
8Muscle hypertrophy of the lower extremities (HP:0008968)4.80092975
9Calf muscle hypertrophy (HP:0008981)4.77724735
10EMG: myopathic abnormalities (HP:0003458)4.52337739
11Hyporeflexia of lower limbs (HP:0002600)4.39432688
12Abnormality of the calf musculature (HP:0001430)3.88406782
13Subaortic stenosis (HP:0001682)3.88146235
14Abnormality of the left ventricular outflow tract (HP:0011103)3.88146235
15Distal arthrogryposis (HP:0005684)3.80898763
16Myoglobinuria (HP:0002913)3.75109305
17Centrally nucleated skeletal muscle fibers (HP:0003687)3.70087884
18Frequent falls (HP:0002359)3.67841301
19Rimmed vacuoles (HP:0003805)3.52791207
20Abnormality of skeletal muscle fiber size (HP:0012084)3.47309503
21Neck muscle weakness (HP:0000467)3.43905913
22Myopathic facies (HP:0002058)3.38755733
23Rhabdomyolysis (HP:0003201)3.34567304
24Asymmetric septal hypertrophy (HP:0001670)3.19313284
25Calcaneovalgus deformity (HP:0001848)3.11379496
26Ulnar deviation of the wrist (HP:0003049)3.06915602
27Increased variability in muscle fiber diameter (HP:0003557)3.01740164
28Sudden death (HP:0001699)2.89662506
29Papillary thyroid carcinoma (HP:0002895)2.86237788
30Muscle fiber splitting (HP:0003555)2.84828329
31Insidious onset (HP:0003587)2.81020283
32Termporal pattern (HP:0011008)2.81020283
33Round ear (HP:0100830)2.78040025
34Scapular winging (HP:0003691)2.70606819
35Increased connective tissue (HP:0009025)2.65932495
36Abnormality of the musculature of the pelvis (HP:0001469)2.64681342
37Abnormality of the hip-girdle musculature (HP:0001445)2.64681342
38Deformed tarsal bones (HP:0008119)2.62417082
39Pelvic girdle muscle weakness (HP:0003749)2.61488374
40Distal lower limb muscle weakness (HP:0009053)2.58265577
41EMG: neuropathic changes (HP:0003445)2.57440869
42Papilledema (HP:0001085)2.50980511
43Bundle branch block (HP:0011710)2.49668007
44Distal lower limb amyotrophy (HP:0008944)2.46544118
45Abnormality of the foot musculature (HP:0001436)2.40464823
46Foot dorsiflexor weakness (HP:0009027)2.39861468
47Ventricular tachycardia (HP:0004756)2.38151015
48Limb-girdle muscle atrophy (HP:0003797)2.37366938
49Proximal amyotrophy (HP:0007126)2.34487864
50Malignant hyperthermia (HP:0002047)2.34101870
51Shoulder girdle muscle weakness (HP:0003547)2.32405352
52Areflexia of lower limbs (HP:0002522)2.31890168
53Fetal akinesia sequence (HP:0001989)2.28089358
54Dilated cardiomyopathy (HP:0001644)2.27387670
55Subacute progressive viral hepatitis (HP:0006572)2.23924598
56Popliteal pterygium (HP:0009756)2.19611193
57Muscle stiffness (HP:0003552)2.16677903
58Peritonitis (HP:0002586)2.15453216
59Abnormality of the calcaneus (HP:0008364)2.12930742
60Dynein arm defect of respiratory motile cilia (HP:0012255)2.05712126
61Absent/shortened dynein arms (HP:0200106)2.05712126
62Spinal cord lesions (HP:0100561)2.02346637
63Syringomyelia (HP:0003396)2.02346637
64Fatigue (HP:0012378)2.01478638
65Limb-girdle muscle weakness (HP:0003325)2.00083101
66Abnormality of the shoulder girdle musculature (HP:0001435)1.99554617
67Generalized muscle weakness (HP:0003324)1.97662762
68Lipoatrophy (HP:0100578)1.93560166
69Mildly elevated creatine phosphokinase (HP:0008180)1.90938581
70Weak cry (HP:0001612)1.87190681
71Metatarsus adductus (HP:0001840)1.87080121
72Heterotopia (HP:0002282)1.85551860
73Periodontitis (HP:0000704)1.85291289
74Muscular dystrophy (HP:0003560)1.83533344
75Bulbar palsy (HP:0001283)1.82196159
76Lower limb amyotrophy (HP:0007210)1.80966909
77Lower limb muscle weakness (HP:0007340)1.76740592
78Menstrual irregularities (HP:0000858)1.74640071
79Thyroid carcinoma (HP:0002890)1.74615026
80Gowers sign (HP:0003391)1.72060734
81Hyperkalemia (HP:0002153)1.69834250
82Brushfield spots (HP:0001088)1.68611015
83Urinary urgency (HP:0000012)1.67970901
84Resting tremor (HP:0002322)1.67350805
85Cortical dysplasia (HP:0002539)1.66535312
86Difficulty walking (HP:0002355)1.63753808
87Spinal rigidity (HP:0003306)1.63622054
88Cystic hygroma (HP:0000476)1.62507628
89Slender build (HP:0001533)1.61911304
90Pheochromocytoma (HP:0002666)1.58587904
91Long clavicles (HP:0000890)1.58169189
92Facial diplegia (HP:0001349)1.57641198
93Difficulty climbing stairs (HP:0003551)1.56015161
94Viral hepatitis (HP:0006562)1.55132001
95Bilateral sensorineural hearing impairment (HP:0008619)1.54557722
96Progressive muscle weakness (HP:0003323)1.54111145
97Death in childhood (HP:0003819)1.54068440
98Right ventricular cardiomyopathy (HP:0011663)1.51255140
99Abnormality of the neuromuscular junction (HP:0003398)1.50415556
100Fatigable weakness (HP:0003473)1.50415556

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN7.09948961
2TTN4.41618301
3LATS12.76225854
4STK38L2.40121590
5PHKG12.37465857
6PHKG22.37465857
7PIK3CG2.35027314
8EPHA32.04392308
9ERBB31.90498350
10MAP3K21.89934585
11PRPF4B1.79218105
12LATS21.78812957
13BRD41.61026523
14IRAK31.59237970
15STK381.57116794
16CCNB11.54114151
17KSR21.52257311
18JAK11.50664176
19AKT31.46174384
20NEK91.44915773
21SCYL21.42821334
22CAMKK21.41281658
23NEK11.40859399
24MAP3K41.40600419
25SIK31.21891759
26MAPK121.19421889
27TRIM281.18586894
28CDK121.17921547
29MARK11.14679675
30RIPK41.12197515
31CAMK1D1.10474812
32BCR1.09626447
33NLK1.08441621
34MAP3K31.07957040
35PRKAA21.07735046
36MAP3K61.07338538
37BLK1.06626518
38RPS6KA41.06034372
39EPHB11.01998436
40MAP2K31.00511101
41BMPR20.98004522
42FGFR30.94976671
43MAP3K70.94960068
44RET0.94945040
45CAMK40.90527990
46ERN10.86745983
47TYK20.85739944
48PDK20.85386231
49PINK10.83612830
50PIK3CA0.83186939
51YES10.81224780
52CDK60.80559050
53SGK30.78559795
54NEK60.77694735
55CAMK1G0.77435617
56MAP3K130.77383315
57SGK20.75703592
58TRPM70.75596751
59PDGFRA0.71769901
60JAK20.70875633
61FGR0.70785145
62MST1R0.69969107
63CSK0.67927939
64MAP3K100.67346934
65MAP3K90.66811466
66MAP2K40.64953657
67MAP3K50.64883127
68MAP3K140.64870095
69MELK0.63878534
70MAP3K10.60766939
71KSR10.60500863
72RAF10.58005913
73MAPK70.57555706
74PKN20.55683760
75ICK0.55077719
76FER0.54380152
77RPS6KB10.52664936
78EIF2AK30.51436941
79INSRR0.50797118
80AKT20.48596881
81RIPK10.48159100
82EEF2K0.47509497
83DYRK1B0.47052945
84PTK2B0.46992189
85PRKD10.46836061
86MOS0.45124638
87ZAP700.45065601
88FGFR40.43602271
89TRIB30.40619962
90PDGFRB0.40481603
91STK100.40217951
92BTK0.39678829
93PRKAA10.39206966
94MAP2K70.39046498
95BRAF0.36652370
96CDC70.36392924
97MAPK110.36227938
98CAMK2B0.34794504
99ARAF0.33849098
100HCK0.32771259

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.07456916
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.53342019
3Dilated cardiomyopathy_Homo sapiens_hsa054142.42073771
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.15937701
5Thyroid cancer_Homo sapiens_hsa052162.08413757
6Endometrial cancer_Homo sapiens_hsa052132.03082517
7Non-small cell lung cancer_Homo sapiens_hsa052231.97046077
8Inositol phosphate metabolism_Homo sapiens_hsa005621.94884981
9Phosphatidylinositol signaling system_Homo sapiens_hsa040701.90866387
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.86621416
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.70095328
12Renal cell carcinoma_Homo sapiens_hsa052111.61760678
13Insulin signaling pathway_Homo sapiens_hsa049101.61409935
14mTOR signaling pathway_Homo sapiens_hsa041501.60818570
15Thyroid hormone signaling pathway_Homo sapiens_hsa049191.60090628
16Pancreatic cancer_Homo sapiens_hsa052121.58346636
17Dorso-ventral axis formation_Homo sapiens_hsa043201.52783713
18Insulin resistance_Homo sapiens_hsa049311.42891027
19Prostate cancer_Homo sapiens_hsa052151.41338162
20Acute myeloid leukemia_Homo sapiens_hsa052211.38023480
21Long-term potentiation_Homo sapiens_hsa047201.34674782
22Glioma_Homo sapiens_hsa052141.29477158
23Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.26072421
24Colorectal cancer_Homo sapiens_hsa052101.24401073
25Adherens junction_Homo sapiens_hsa045201.20688442
26AMPK signaling pathway_Homo sapiens_hsa041521.19299157
27FoxO signaling pathway_Homo sapiens_hsa040681.19195248
28Chronic myeloid leukemia_Homo sapiens_hsa052201.17714590
29Adipocytokine signaling pathway_Homo sapiens_hsa049201.16679062
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.15619943
31Glucagon signaling pathway_Homo sapiens_hsa049221.14562990
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.06844036
33B cell receptor signaling pathway_Homo sapiens_hsa046621.05895061
34Longevity regulating pathway - mammal_Homo sapiens_hsa042111.05010126
35Hepatitis B_Homo sapiens_hsa051611.04473403
36AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02484958
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99906313
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.99901128
39Circadian rhythm_Homo sapiens_hsa047100.99863026
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.99028078
41cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99027082
42HIF-1 signaling pathway_Homo sapiens_hsa040660.96881875
43Neurotrophin signaling pathway_Homo sapiens_hsa047220.95954395
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.95228380
45Focal adhesion_Homo sapiens_hsa045100.93922140
46Platelet activation_Homo sapiens_hsa046110.91935235
47Sphingolipid signaling pathway_Homo sapiens_hsa040710.90551744
48Central carbon metabolism in cancer_Homo sapiens_hsa052300.89437418
49Carbon metabolism_Homo sapiens_hsa012000.89425885
50Small cell lung cancer_Homo sapiens_hsa052220.88495645
51Choline metabolism in cancer_Homo sapiens_hsa052310.87326767
52Oxytocin signaling pathway_Homo sapiens_hsa049210.87171664
53GnRH signaling pathway_Homo sapiens_hsa049120.87134599
54T cell receptor signaling pathway_Homo sapiens_hsa046600.87058635
55Osteoclast differentiation_Homo sapiens_hsa043800.85238567
56ErbB signaling pathway_Homo sapiens_hsa040120.82965299
57VEGF signaling pathway_Homo sapiens_hsa043700.82646294
58Prolactin signaling pathway_Homo sapiens_hsa049170.82336654
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.80655387
60Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79085935
61Proteoglycans in cancer_Homo sapiens_hsa052050.76337598
62Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.74353516
63Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.73239433
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72490695
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71188883
66Measles_Homo sapiens_hsa051620.70897342
67Melanoma_Homo sapiens_hsa052180.70724677
68Viral carcinogenesis_Homo sapiens_hsa052030.69636150
69Gap junction_Homo sapiens_hsa045400.69392190
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69194744
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68901910
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.68184283
73Cardiac muscle contraction_Homo sapiens_hsa042600.67873311
74Toll-like receptor signaling pathway_Homo sapiens_hsa046200.67142396
75Calcium signaling pathway_Homo sapiens_hsa040200.66490282
76Vibrio cholerae infection_Homo sapiens_hsa051100.65679659
77Sphingolipid metabolism_Homo sapiens_hsa006000.64280855
78Type II diabetes mellitus_Homo sapiens_hsa049300.63960313
79Hepatitis C_Homo sapiens_hsa051600.62857249
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60992903
81Viral myocarditis_Homo sapiens_hsa054160.60566875
82Estrogen signaling pathway_Homo sapiens_hsa049150.60218135
83Amoebiasis_Homo sapiens_hsa051460.58686751
84Tuberculosis_Homo sapiens_hsa051520.58651784
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58344503
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58071625
87Toxoplasmosis_Homo sapiens_hsa051450.57341831
88Endocytosis_Homo sapiens_hsa041440.56869673
89Shigellosis_Homo sapiens_hsa051310.56095252
90Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.55872515
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55781655
92Oocyte meiosis_Homo sapiens_hsa041140.55544746
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53242333
94Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.53053626
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.51047314
96Pyruvate metabolism_Homo sapiens_hsa006200.48546037
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46116061
98Chemokine signaling pathway_Homo sapiens_hsa040620.44676397
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44616625
100Renin secretion_Homo sapiens_hsa049240.42427833

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