ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	proteasome assembly (GO:0043248)	5.61332570
2	ribosome assembly (GO:0042255)	4.33465818
3	cullin deneddylation (GO:0010388)	4.18187899
4	protein deneddylation (GO:0000338)	4.13848341
5	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.93033644
6	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.92795522
7	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.87786601
8	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.83255877
9	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.83255877
10	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.83034257
11	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.83034257
12	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.83034257
13	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.73839824
14	regulation of cellular amino acid metabolic process (GO:0006521)	3.72185402
15	DNA double-strand break processing (GO:0000729)	3.71959823
16	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.63945588
17	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.63945588
18	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.60875702
19	negative regulation of ligase activity (GO:0051352)	3.56441750
20	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.56441750
21	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.49874900
22	protein K6-linked ubiquitination (GO:0085020)	3.45813043
23	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	3.35424423
24	positive regulation of ligase activity (GO:0051351)	3.31133052
25	histone H2A acetylation (GO:0043968)	3.11767298
26	DNA damage response, signal transduction by p53 class mediator (GO:0030330)	3.03961769
27	lactate metabolic process (GO:0006089)	3.00878122
28	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.96683805
29	piRNA metabolic process (GO:0034587)	2.94300486
30	response to pheromone (GO:0019236)	2.92606498
31	DNA catabolic process, exonucleolytic (GO:0000738)	2.87419041
32	negative regulation of protein ubiquitination (GO:0031397)	2.86921716
33	double-strand break repair via nonhomologous end joining (GO:0006303)	2.86701592
34	non-recombinational repair (GO:0000726)	2.86701592
35	preassembly of GPI anchor in ER membrane (GO:0016254)	2.85643986
36	rRNA modification (GO:0000154)	2.84327748
37	regulation of ubiquitin-protein transferase activity (GO:0051438)	2.83510520
38	regulation of ligase activity (GO:0051340)	2.82286732
39	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.82122544
40	branched-chain amino acid catabolic process (GO:0009083)	2.81896078
41	rRNA methylation (GO:0031167)	2.81239501
42	positive regulation of cell cycle arrest (GO:0071158)	2.79021083
43	regulation of retinoic acid receptor signaling pathway (GO:0048385)	2.78102987
44	regulation of translation in response to stress (GO:0043555)	2.77247042
45	DNA damage response, detection of DNA damage (GO:0042769)	2.76907934
46	platelet dense granule organization (GO:0060155)	2.75300818
47	synapsis (GO:0007129)	2.74657193
48	C-terminal protein lipidation (GO:0006501)	2.72802910
49	negative regulation of protein modification by small protein conjugation or removal (GO:1903321)	2.70686653
50	peptidyl-histidine modification (GO:0018202)	2.68170426
51	adenosine metabolic process (GO:0046085)	2.63561742
52	DNA deamination (GO:0045006)	2.61658758
53	protein K11-linked ubiquitination (GO:0070979)	2.61068802
54	antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)	2.59197031
55	protein heterotetramerization (GO:0051290)	2.58121938
56	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.57347355
57	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	2.56954382
58	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.53621256
59	regulation of mitotic spindle checkpoint (GO:1903504)	2.53621256
60	negative regulation of cell cycle G1/S phase transition (GO:1902807)	2.52864629
61	negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)	2.52864629
62	signal transduction in response to DNA damage (GO:0042770)	2.52472749
63	histone mRNA catabolic process (GO:0071044)	2.50462154
64	GMP metabolic process (GO:0046037)	2.49512985
65	DNA integration (GO:0015074)	2.49462702
66	rRNA catabolic process (GO:0016075)	2.49003939
67	DNA replication-dependent nucleosome organization (GO:0034723)	2.45653589
68	DNA replication-dependent nucleosome assembly (GO:0006335)	2.45653589
69	replication fork processing (GO:0031297)	2.45431797
70	C-terminal protein amino acid modification (GO:0018410)	2.45213383
71	G1/S transition of mitotic cell cycle (GO:0000082)	2.43339314
72	cell cycle G1/S phase transition (GO:0044843)	2.43339314
73	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.42658293
74	attachment of spindle microtubules to kinetochore (GO:0008608)	2.42480472
75	regulation of cellular amine metabolic process (GO:0033238)	2.40305786
76	hepatocyte apoptotic process (GO:0097284)	2.39453616
77	tRNA methylation (GO:0030488)	2.36599070
78	negative regulation of thymocyte apoptotic process (GO:0070244)	2.36310994
79	signal peptide processing (GO:0006465)	2.36229241
80	negative regulation of neurological system process (GO:0031645)	2.34886671
81	positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)	2.34431179
82	regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)	2.34431179
83	isotype switching (GO:0045190)	2.34129617
84	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.34129617
85	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.34129617
86	purine-containing compound salvage (GO:0043101)	2.33876450
87	intestinal epithelial cell development (GO:0060576)	2.33412201
88	tRNA aminoacylation for protein translation (GO:0006418)	2.32325686
89	cell wall macromolecule catabolic process (GO:0016998)	2.32257884
90	cytochrome complex assembly (GO:0017004)	2.32172780
91	recombinational repair (GO:0000725)	2.32041113
92	COPII vesicle coating (GO:0048208)	2.30629144
93	positive regulation of protein ubiquitination (GO:0031398)	2.30400587
94	respiratory chain complex IV assembly (GO:0008535)	2.29865416
95	double-strand break repair via homologous recombination (GO:0000724)	2.29701519
96	amino acid activation (GO:0043038)	2.29022470
97	tRNA aminoacylation (GO:0043039)	2.29022470
98	ER overload response (GO:0006983)	2.28905354
99	regulation of cell cycle arrest (GO:0071156)	2.27624157
100	protein-cofactor linkage (GO:0018065)	2.27470421

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.14844069
2	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.89219851
3	* GABP_17652178_ChIP-ChIP_JURKAT_Human	3.75550817
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.18243154
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.92989397
6	ELK1_19687146_ChIP-ChIP_HELA_Human	2.89442626
7	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.88369130
8	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.87279199
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.78533051
10	VDR_23849224_ChIP-Seq_CD4+_Human	2.72416568
11	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.68262080
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.54864758
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.47265346
14	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.45608365
15	ZNF274_21170338_ChIP-Seq_K562_Hela	2.40008936
16	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.38344776
17	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.35085241
18	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.27420049
19	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.25376682
20	PADI4_21655091_ChIP-ChIP_MCF-7_Human	2.13794554
21	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.04079978
22	FOXP3_21729870_ChIP-Seq_TREG_Human	2.01385597
23	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	2.00209804
24	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.93383997
25	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.91970658
26	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.91944053
27	DCP1A_22483619_ChIP-Seq_HELA_Human	1.88354408
28	IGF1R_20145208_ChIP-Seq_DFB_Human	1.80823549
29	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.78965634
30	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.78241595
31	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.68302448
32	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.68125655
33	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.58890634
34	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.58050395
35	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.57784721
36	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.52129968
37	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.49584549
38	E2F7_22180533_ChIP-Seq_HELA_Human	1.48955643
39	VDR_22108803_ChIP-Seq_LS180_Human	1.48527756
40	* GABP_19822575_ChIP-Seq_HepG2_Human	1.47378257
41	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.43229769
42	TFEB_21752829_ChIP-Seq_HELA_Human	1.39662593
43	EWS_26573619_Chip-Seq_HEK293_Human	1.38853422
44	IRF1_19129219_ChIP-ChIP_H3396_Human	1.38216376
45	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.34353111
46	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.33330152
47	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.32857717
48	GATA3_26560356_Chip-Seq_TH2_Human	1.26605776
49	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.25660249
50	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.25545948
51	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.20171247
52	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.17796458
53	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.15950138
54	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.15520992
55	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.12360122
56	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.12290927
57	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.12233915
58	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.12144637
59	ER_23166858_ChIP-Seq_MCF-7_Human	1.11658623
60	MYC_18940864_ChIP-ChIP_HL60_Human	1.10408697
61	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.09225407
62	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.07408474
63	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.05813602
64	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.05748944
65	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.05219120
66	KDM5A_27292631_Chip-Seq_BREAST_Human	1.04170555
67	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.04055912
68	* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.02279201
69	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.02007477
70	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.00928421
71	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.00626529
72	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.99339819
73	* SMAD4_19686287_ChIP-ChIP_HaCaT_Human	0.98994884
74	SPI1_23547873_ChIP-Seq_NB4_Human	0.98537015
75	MYB_26560356_Chip-Seq_TH2_Human	0.97972891
76	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	0.97653373
77	ELF5_23300383_ChIP-Seq_T47D_Human	0.96103004
78	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.94830109
79	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	0.94683173
80	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.94116510
81	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.93774088
82	* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.92150945
83	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.90406694
84	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.89770761
85	GATA1_22025678_ChIP-Seq_K562_Human	0.89310950
86	P300_19829295_ChIP-Seq_ESCs_Human	0.89196397
87	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.87952871
88	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.87754701
89	CIITA_25753668_ChIP-Seq_RAJI_Human	0.85718689
90	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.85331862
91	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.84221753
92	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.83576428
93	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.82740340
94	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.81972479
95	FUS_26573619_Chip-Seq_HEK293_Human	0.81410107
96	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.81011591
97	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.80507136
98	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.80327594
99	TP53_22573176_ChIP-Seq_HFKS_Human	0.79428724
100	TTF2_22483619_ChIP-Seq_HELA_Human	0.79294541

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008058_abnormal_DNA_repair	3.66508765
2	MP0003806_abnormal_nucleotide_metabolis	2.87956110
3	MP0003786_premature_aging	2.77112676
4	MP0010094_abnormal_chromosome_stability	2.60337090
5	MP0006054_spinal_hemorrhage	2.54769030
6	MP0003950_abnormal_plasma_membrane	2.45017296
7	MP0000465_gastrointestinal_hemorrhage	2.19337944
8	MP0002102_abnormal_ear_morphology	2.17480242
9	MP0002148_abnormal_hypersensitivity_rea	2.04999170
10	MP0000516_abnormal_urinary_system	1.93269221
11	MP0005367_renal/urinary_system_phenotyp	1.93269221
12	MP0003693_abnormal_embryo_hatching	1.92529042
13	MP0001835_abnormal_antigen_presentation	1.92527313
14	MP0001873_stomach_inflammation	1.89552802
15	MP0009697_abnormal_copulation	1.87742884
16	MP0003186_abnormal_redox_activity	1.85427908
17	MP0008007_abnormal_cellular_replicative	1.84709690
18	MP0002166_altered_tumor_susceptibility	1.82227114
19	MP0003656_abnormal_erythrocyte_physiolo	1.81081004
20	MP0005671_abnormal_response_to	1.80297875
21	MP0003724_increased_susceptibility_to	1.79712152
22	MP0000427_abnormal_hair_cycle	1.76024641
23	MP0009785_altered_susceptibility_to	1.74844264
24	MP0002006_tumorigenesis	1.68508739
25	MP0000372_irregular_coat_pigmentation	1.57820769
26	MP0005000_abnormal_immune_tolerance	1.54074788
27	MP0003763_abnormal_thymus_physiology	1.49268410
28	MP0003077_abnormal_cell_cycle	1.48297037
29	MP0009764_decreased_sensitivity_to	1.48118064
30	MP0003718_maternal_effect	1.45650344
31	MP0006072_abnormal_retinal_apoptosis	1.45529613
32	MP0004782_abnormal_surfactant_physiolog	1.41302822
33	MP0005253_abnormal_eye_physiology	1.40064799
34	MP0005075_abnormal_melanosome_morpholog	1.37857770
35	MP0010234_abnormal_vibrissa_follicle	1.37726201
36	MP0010678_abnormal_skin_adnexa	1.37528957
37	MP0001853_heart_inflammation	1.36129350
38	MP0008057_abnormal_DNA_replication	1.35237929
39	MP0004957_abnormal_blastocyst_morpholog	1.30844515
40	MP0005084_abnormal_gallbladder_morpholo	1.29929876
41	MP0001764_abnormal_homeostasis	1.29538775
42	MP0002254_reproductive_system_inflammat	1.28203776
43	MP0001800_abnormal_humoral_immune	1.28199931
44	MP0000358_abnormal_cell_content/	1.27317645
45	MP0002405_respiratory_system_inflammati	1.26243748
46	MP0003111_abnormal_nucleus_morphology	1.26043234
47	MP0000383_abnormal_hair_follicle	1.24381070
48	MP0005410_abnormal_fertilization	1.24198182
49	MP0008995_early_reproductive_senescence	1.23038800
50	MP0006036_abnormal_mitochondrial_physio	1.21533972
51	MP0002452_abnormal_antigen_presenting	1.20168918
52	MP0002723_abnormal_immune_serum	1.18772379
53	MP0006082_CNS_inflammation	1.15462343
54	MP0009333_abnormal_splenocyte_physiolog	1.12955606
55	MP0002234_abnormal_pharynx_morphology	1.11127101
56	MP0001845_abnormal_inflammatory_respons	1.08446526
57	MP0000015_abnormal_ear_pigmentation	1.08082525
58	MP0005387_immune_system_phenotype	1.06350999
59	MP0001790_abnormal_immune_system	1.06350999
60	MP0005248_abnormal_Harderian_gland	1.06240584
61	MP0005310_abnormal_salivary_gland	1.05044200
62	MP0002138_abnormal_hepatobiliary_system	1.02078953
63	MP0002420_abnormal_adaptive_immunity	1.01795671
64	MP0002837_dystrophic_cardiac_calcinosis	1.01409943
65	MP0001819_abnormal_immune_cell	1.00906421
66	MP0000689_abnormal_spleen_morphology	1.00755761
67	MP0002095_abnormal_skin_pigmentation	1.00715654
68	MP0000613_abnormal_salivary_gland	1.00232056
69	MP0001545_abnormal_hematopoietic_system	0.98112282
70	MP0005397_hematopoietic_system_phenotyp	0.98112282
71	MP0002163_abnormal_gland_morphology	0.96741212
72	MP0008961_abnormal_basal_metabolism	0.95698703
73	MP0004264_abnormal_extraembryonic_tissu	0.95239918
74	MP0006035_abnormal_mitochondrial_morpho	0.92742746
75	MP0002722_abnormal_immune_system	0.91950631
76	MP0001929_abnormal_gametogenesis	0.91678745
77	MP0000569_abnormal_digit_pigmentation	0.90567764
78	MP0002332_abnormal_exercise_endurance	0.89870158
79	MP0008932_abnormal_embryonic_tissue	0.89345597
80	MP0001243_abnormal_dermal_layer	0.88921442
81	MP0003868_abnormal_feces_composition	0.88893835
82	MP0001529_abnormal_vocalization	0.88763954
83	MP0000538_abnormal_urinary_bladder	0.88346751
84	MP0008789_abnormal_olfactory_epithelium	0.87788826
85	MP0010307_abnormal_tumor_latency	0.86780276
86	MP0010352_gastrointestinal_tract_polyps	0.86465023
87	MP0008877_abnormal_DNA_methylation	0.86449379
88	MP0002398_abnormal_bone_marrow	0.84723651
89	MP0001119_abnormal_female_reproductive	0.81779173
90	MP0002751_abnormal_autonomic_nervous	0.81117179
91	MP0002019_abnormal_tumor_incidence	0.80501896
92	MP0003866_abnormal_defecation	0.80488269
93	MP0003436_decreased_susceptibility_to	0.79211466
94	MP0003195_calcinosis	0.79086446
95	MP0004147_increased_porphyrin_level	0.78624486
96	MP0002160_abnormal_reproductive_system	0.77007991
97	MP0000627_abnormal_mammary_gland	0.74435732
98	MP0005025_abnormal_response_to	0.73907142
99	MP0003943_abnormal_hepatobiliary_system	0.73515165
100	MP0000716_abnormal_immune_system	0.72950455

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal protein glycosylation (HP:0012346)	2.99667984
2	Abnormal glycosylation (HP:0012345)	2.99667984
3	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.99667984
4	Abnormal protein N-linked glycosylation (HP:0012347)	2.99667984
5	Dyschromatopsia (HP:0007641)	2.92928027
6	Aplasia/hypoplasia of the uterus (HP:0008684)	2.90145607
7	Hypoplasia of the uterus (HP:0000013)	2.89468770
8	Type I transferrin isoform profile (HP:0003642)	2.87844775
9	Microvesicular hepatic steatosis (HP:0001414)	2.83118926
10	Stomatitis (HP:0010280)	2.73936129
11	Thyroiditis (HP:0100646)	2.70159929
12	Abnormality of methionine metabolism (HP:0010901)	2.69300371
13	Large for gestational age (HP:0001520)	2.46650559
14	Pancreatic cysts (HP:0001737)	2.40448242
15	Tubulointerstitial nephritis (HP:0001970)	2.38640776
16	Renal cortical cysts (HP:0000803)	2.35640882
17	Autoimmune hemolytic anemia (HP:0001890)	2.34656719
18	Reduced antithrombin III activity (HP:0001976)	2.34634568
19	Abnormality of the preputium (HP:0100587)	2.33774880
20	Chronic diarrhea (HP:0002028)	2.33325021
21	Amyotrophic lateral sclerosis (HP:0007354)	2.31047804
22	Breast carcinoma (HP:0003002)	2.30434521
23	Methylmalonic aciduria (HP:0012120)	2.28268049
24	Bile duct proliferation (HP:0001408)	2.28152514
25	Abnormal biliary tract physiology (HP:0012439)	2.28152514
26	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.27131382
27	Albinism (HP:0001022)	2.24141240
28	True hermaphroditism (HP:0010459)	2.23413004
29	Hepatocellular necrosis (HP:0001404)	2.22172324
30	Medial flaring of the eyebrow (HP:0010747)	2.21040409
31	Hypoproteinemia (HP:0003075)	2.19497477
32	Methylmalonic acidemia (HP:0002912)	2.19383641
33	Carpal bone hypoplasia (HP:0001498)	2.18954652
34	Hepatic necrosis (HP:0002605)	2.16695741
35	Cutaneous melanoma (HP:0012056)	2.15624567
36	Pancytopenia (HP:0001876)	2.13764579
37	Short tibia (HP:0005736)	2.13115781
38	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.11601941
39	Increased serum pyruvate (HP:0003542)	2.09380259
40	Increased CSF lactate (HP:0002490)	2.09253337
41	Abnormality of chromosome stability (HP:0003220)	2.07605088
42	Abnormality of the ileum (HP:0001549)	2.07464130
43	Aplastic anemia (HP:0001915)	2.06280515
44	Abnormality of the renal cortex (HP:0011035)	2.06255535
45	Sloping forehead (HP:0000340)	2.05454953
46	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.04984802
47	Meckel diverticulum (HP:0002245)	2.04175737
48	Abnormality of glycolysis (HP:0004366)	2.02166793
49	Severe combined immunodeficiency (HP:0004430)	2.01880784
50	IgG deficiency (HP:0004315)	2.01347541
51	Nephrogenic diabetes insipidus (HP:0009806)	1.99929611
52	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.99768833
53	Retinal dysplasia (HP:0007973)	1.98514093
54	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.98096463
55	Constricted visual fields (HP:0001133)	1.96991755
56	Molar tooth sign on MRI (HP:0002419)	1.96807037
57	Abnormality of midbrain morphology (HP:0002418)	1.96807037
58	Attenuation of retinal blood vessels (HP:0007843)	1.96015773
59	Congenital primary aphakia (HP:0007707)	1.95957267
60	Prostate neoplasm (HP:0100787)	1.95147293
61	Neoplasm of the adrenal gland (HP:0100631)	1.94861436
62	Clubbing of toes (HP:0100760)	1.94581307
63	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.92501827
64	Hypokinesia (HP:0002375)	1.91296861
65	Abnormality of B cell number (HP:0010975)	1.90601256
66	Increased serum lactate (HP:0002151)	1.90556135
67	Chronic hepatic failure (HP:0100626)	1.89118841
68	Pancreatic fibrosis (HP:0100732)	1.86879643
69	IgM deficiency (HP:0002850)	1.86796999
70	Hypothermia (HP:0002045)	1.85219986
71	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.85183459
72	3-Methylglutaconic aciduria (HP:0003535)	1.84605297
73	Abolished electroretinogram (ERG) (HP:0000550)	1.84452492
74	Entropion (HP:0000621)	1.83826844
75	Median cleft lip (HP:0000161)	1.82486622
76	Abnormal umbilical cord blood vessels (HP:0011403)	1.82365342
77	Single umbilical artery (HP:0001195)	1.82365342
78	Abnormality of the fetal cardiovascular system (HP:0010948)	1.82365342
79	Ependymoma (HP:0002888)	1.81707022
80	Small intestinal stenosis (HP:0012848)	1.80777149
81	Duodenal stenosis (HP:0100867)	1.80777149
82	Abnormality of eosinophils (HP:0001879)	1.79792209
83	B lymphocytopenia (HP:0010976)	1.78984528
84	Mitochondrial inheritance (HP:0001427)	1.78227540
85	Abnormality of the astrocytes (HP:0100707)	1.75542950
86	Astrocytoma (HP:0009592)	1.75542950
87	Autoimmune thrombocytopenia (HP:0001973)	1.74862088
88	Adrenal hypoplasia (HP:0000835)	1.74371306
89	Combined immunodeficiency (HP:0005387)	1.74284714
90	Type II lissencephaly (HP:0007260)	1.73877083
91	Eosinophilia (HP:0001880)	1.73669357
92	Neutropenia (HP:0001875)	1.73255002
93	Acute hepatic failure (HP:0006554)	1.72881419
94	Thyroid carcinoma (HP:0002890)	1.72083773
95	Posterior subcapsular cataract (HP:0007787)	1.69761837
96	Postnatal microcephaly (HP:0005484)	1.67273979
97	Lactic acidosis (HP:0003128)	1.66394520
98	Chromsome breakage (HP:0040012)	1.65742498
99	Abnormality of the metopic suture (HP:0005556)	1.65567807
100	Abnormality of the anterior horn cell (HP:0006802)	1.65482486

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EIF2AK3	5.22380752
2	TRIM28	3.76927768
3	MST4	3.31170716
4	EIF2AK1	3.04517035
5	FRK	2.83568271
6	BUB1	2.77373203
7	ZAK	2.50854535
8	BCKDK	2.38267582
9	STK16	2.25939092
10	SRPK1	2.15691359
11	PDK2	2.15336188
12	NUAK1	2.09552321
13	ERBB3	2.04174422
14	SIK3	2.00404817
15	TXK	1.99255036
16	BCR	1.76945998
17	VRK2	1.68207354
18	BRSK2	1.63017489
19	TAOK3	1.57704572
20	CCNB1	1.56895650
21	MAP4K2	1.56687848
22	TSSK6	1.53794089
23	MAP3K12	1.52790120
24	INSRR	1.49489586
25	NEK1	1.46602231
26	PINK1	1.39834366
27	PBK	1.36111246
28	VRK1	1.36072854
29	PLK3	1.24970755
30	FER	1.24879872
31	BMPR1B	1.23822716
32	BRD4	1.19979816
33	CSNK1A1L	1.17591642
34	CSNK1G3	1.13840418
35	RPS6KA4	1.06486340
36	WEE1	1.05982458
37	TIE1	1.03500145
38	GRK1	1.02191290
39	PLK4	0.98758260
40	CSNK1G1	0.95884064
41	TLK1	0.94300976
42	MAP3K3	0.93436457
43	MARK3	0.87811134
44	CDK8	0.87637384
45	IKBKB	0.86903035
46	PIM2	0.85118566
47	SCYL2	0.84609810
48	EIF2AK2	0.81645443
49	ADRBK2	0.80107357
50	RPS6KA5	0.78879399
51	TESK2	0.78771935
52	NEK6	0.77965129
53	BMPR2	0.76890262
54	FES	0.76168735
55	MYLK	0.73431433
56	TBK1	0.72293960
57	STK10	0.71529246
58	MUSK	0.70618473
59	CSNK1G2	0.68635989
60	STK39	0.65248932
61	WNK3	0.64553430
62	PLK1	0.64061819
63	IKBKE	0.63745407
64	FLT3	0.62897077
65	IRAK3	0.56042970
66	RAF1	0.54363147
67	MAP2K7	0.53628828
68	OXSR1	0.52728366
69	PRKCE	0.51718224
70	TGFBR1	0.51225352
71	PLK2	0.50322675
72	TYK2	0.49943684
73	PTK2B	0.48296683
74	PRKD3	0.47720175
75	ERBB4	0.47200504
76	GRK7	0.45879219
77	MST1R	0.44790775
78	ATR	0.44739180
79	PAK3	0.44331601
80	TEC	0.44174124
81	MAP3K5	0.43570216
82	AURKB	0.43009957
83	ATM	0.42164897
84	PRKCQ	0.39338952
85	MKNK1	0.38793075
86	PIK3CA	0.34040415
87	CHUK	0.33452511
88	KDR	0.33299082
89	TTK	0.32222359
90	STK38L	0.31783814
91	ABL1	0.31591051
92	KSR1	0.30475489
93	BRSK1	0.30267328
94	DAPK1	0.29936109
95	CSNK2A1	0.29770887
96	EPHA3	0.29648771
97	EGFR	0.29636428
98	NME2	0.27474136
99	TGFBR2	0.27132056
100	ILK	0.25935518

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	5.15991196
2	Protein export_Homo sapiens_hsa03060	2.93819324
3	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.89817044
4	Non-homologous end-joining_Homo sapiens_hsa03450	2.77227786
5	Fanconi anemia pathway_Homo sapiens_hsa03460	2.45723603
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.32794821
7	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.31272792
8	Fatty acid elongation_Homo sapiens_hsa00062	2.15779664
9	Mismatch repair_Homo sapiens_hsa03430	2.08936653
10	Propanoate metabolism_Homo sapiens_hsa00640	2.06531637
11	Homologous recombination_Homo sapiens_hsa03440	2.02429533
12	RNA polymerase_Homo sapiens_hsa03020	2.00155758
13	Sulfur metabolism_Homo sapiens_hsa00920	1.96833976
14	Basal transcription factors_Homo sapiens_hsa03022	1.91787227
15	DNA replication_Homo sapiens_hsa03030	1.79301726
16	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.78611004
17	RNA transport_Homo sapiens_hsa03013	1.77169519
18	Base excision repair_Homo sapiens_hsa03410	1.74213403
19	Regulation of autophagy_Homo sapiens_hsa04140	1.73680663
20	Nucleotide excision repair_Homo sapiens_hsa03420	1.61771192
21	Selenocompound metabolism_Homo sapiens_hsa00450	1.58138710
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.55081135
23	Pyrimidine metabolism_Homo sapiens_hsa00240	1.48572286
24	RNA degradation_Homo sapiens_hsa03018	1.43722532
25	Legionellosis_Homo sapiens_hsa05134	1.42554366
26	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.37733903
27	p53 signaling pathway_Homo sapiens_hsa04115	1.25966729
28	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.24827003
29	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.22120742
30	Spliceosome_Homo sapiens_hsa03040	1.15570516
31	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.14966048
32	Purine metabolism_Homo sapiens_hsa00230	1.14426934
33	Rheumatoid arthritis_Homo sapiens_hsa05323	1.07207198
34	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.06963717
35	Primary immunodeficiency_Homo sapiens_hsa05340	1.04025702
36	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.02701965
37	Measles_Homo sapiens_hsa05162	1.01936016
38	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.01747261
39	Collecting duct acid secretion_Homo sapiens_hsa04966	1.00887763
40	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.00806815
41	Herpes simplex infection_Homo sapiens_hsa05168	1.00677867
42	Butanoate metabolism_Homo sapiens_hsa00650	1.00582752
43	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.97326549
44	Glutathione metabolism_Homo sapiens_hsa00480	0.93592899
45	Type I diabetes mellitus_Homo sapiens_hsa04940	0.90657970
46	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.88418415
47	Cell cycle_Homo sapiens_hsa04110	0.87960950
48	Peroxisome_Homo sapiens_hsa04146	0.87925840
49	Allograft rejection_Homo sapiens_hsa05330	0.87741544
50	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.87477874
51	Circadian rhythm_Homo sapiens_hsa04710	0.86289188
52	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.85669201
53	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.84592744
54	Caffeine metabolism_Homo sapiens_hsa00232	0.84028828
55	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.81956690
56	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.78790369
57	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.77797865
58	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.77485323
59	Sphingolipid metabolism_Homo sapiens_hsa00600	0.76562975
60	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.75522152
61	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.74330960
62	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.73061435
63	Apoptosis_Homo sapiens_hsa04210	0.72590931
64	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.72274722
65	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.70540056
66	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.69952911
67	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.69625656
68	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.69312224
69	Oxidative phosphorylation_Homo sapiens_hsa00190	0.68135122
70	Shigellosis_Homo sapiens_hsa05131	0.67087356
71	Vibrio cholerae infection_Homo sapiens_hsa05110	0.66039058
72	One carbon pool by folate_Homo sapiens_hsa00670	0.65224106
73	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.64959046
74	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.63624569
75	Parkinsons disease_Homo sapiens_hsa05012	0.63183483
76	Graft-versus-host disease_Homo sapiens_hsa05332	0.62981180
77	Antigen processing and presentation_Homo sapiens_hsa04612	0.62449055
78	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.62013573
79	Steroid biosynthesis_Homo sapiens_hsa00100	0.61234023
80	Viral carcinogenesis_Homo sapiens_hsa05203	0.58201500
81	Hepatitis B_Homo sapiens_hsa05161	0.55951226
82	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.55031457
83	Lysosome_Homo sapiens_hsa04142	0.53772587
84	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.53690741
85	Tryptophan metabolism_Homo sapiens_hsa00380	0.53136493
86	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.53004374
87	Folate biosynthesis_Homo sapiens_hsa00790	0.51579281
88	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.50797537
89	TNF signaling pathway_Homo sapiens_hsa04668	0.49686064
90	mRNA surveillance pathway_Homo sapiens_hsa03015	0.48971784
91	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.47997296
92	Oocyte meiosis_Homo sapiens_hsa04114	0.47698810
93	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.47611990
94	Metabolic pathways_Homo sapiens_hsa01100	0.45987970
95	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.44722349
96	Influenza A_Homo sapiens_hsa05164	0.44316991
97	Phagosome_Homo sapiens_hsa04145	0.44040755
98	Alcoholism_Homo sapiens_hsa05034	0.43805054
99	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.43679390
100	Salmonella infection_Homo sapiens_hsa05132	0.40871289

ZNF410

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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