ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sulfation (GO:0051923)	6.15032984
2	behavioral response to nicotine (GO:0035095)	4.89807670
3	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.58143343
4	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.58143343
5	NADH dehydrogenase complex assembly (GO:0010257)	4.58143343
6	DNA deamination (GO:0045006)	4.51661608
7	cell proliferation in forebrain (GO:0021846)	4.46328671
8	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	4.05387539
9	protein complex biogenesis (GO:0070271)	4.04723203
10	gamma-aminobutyric acid transport (GO:0015812)	4.00210930
11	cellular response to ATP (GO:0071318)	3.96127385
12	water-soluble vitamin biosynthetic process (GO:0042364)	3.95876893
13	regulation of glomerulus development (GO:0090192)	3.90153265
14	regulation of germinal center formation (GO:0002634)	3.81144732
15	somite development (GO:0061053)	3.75413772
16	mitochondrial respiratory chain complex assembly (GO:0033108)	3.63622769
17	protein polyglutamylation (GO:0018095)	3.58214157
18	interferon-gamma secretion (GO:0072643)	3.56596987
19	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla	3.54989569
20	dentate gyrus development (GO:0021542)	3.47726819
21	detection of light stimulus involved in visual perception (GO:0050908)	3.46951357
22	detection of light stimulus involved in sensory perception (GO:0050962)	3.46951357
23	positive regulation of cAMP-mediated signaling (GO:0043950)	3.44235599
24	negative regulation of telomere maintenance (GO:0032205)	3.42583448
25	pharyngeal system development (GO:0060037)	3.39559274
26	positive regulation of potassium ion transmembrane transport (GO:1901381)	3.38737059
27	cellular response to exogenous dsRNA (GO:0071360)	3.27062268
28	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	3.22419871
29	regulation of mesoderm development (GO:2000380)	3.21102007
30	DNA damage response, signal transduction resulting in transcription (GO:0042772)	3.17369579
31	response to xenobiotic stimulus (GO:0009410)	3.13993059
32	magnesium ion transport (GO:0015693)	3.03666631
33	positive regulation of defense response to virus by host (GO:0002230)	3.03068067
34	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.98354304
35	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.98354304
36	transmission of nerve impulse (GO:0019226)	2.96899515
37	activated T cell proliferation (GO:0050798)	2.96320791
38	indolalkylamine metabolic process (GO:0006586)	2.94773884
39	response to pheromone (GO:0019236)	2.91161957
40	regulation of DNA endoreduplication (GO:0032875)	2.88680912
41	ovulation cycle (GO:0042698)	2.88194056
42	membrane repolarization during action potential (GO:0086011)	2.87632540
43	cellular anion homeostasis (GO:0030002)	2.86186940
44	preassembly of GPI anchor in ER membrane (GO:0016254)	2.85166218
45	negative regulation of systemic arterial blood pressure (GO:0003085)	2.81140543
46	neuronal action potential (GO:0019228)	2.80548598
47	regulation of cell proliferation involved in kidney development (GO:1901722)	2.80506921
48	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.78749593
49	indole-containing compound catabolic process (GO:0042436)	2.78704787
50	indolalkylamine catabolic process (GO:0046218)	2.78704787
51	tryptophan catabolic process (GO:0006569)	2.78704787
52	positive regulation of synapse maturation (GO:0090129)	2.75758872
53	regulation of skeletal muscle contraction (GO:0014819)	2.73762163
54	negative regulation of mast cell activation (GO:0033004)	2.72751276
55	kynurenine metabolic process (GO:0070189)	2.71955196
56	positive regulation of triglyceride biosynthetic process (GO:0010867)	2.69484397
57	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	2.67251929
58	parturition (GO:0007567)	2.67233369
59	positive regulation of fatty acid oxidation (GO:0046321)	2.65446176
60	positive regulation of glomerulus development (GO:0090193)	2.65430036
61	primary amino compound metabolic process (GO:1901160)	2.63871777
62	cornea development in camera-type eye (GO:0061303)	2.63576290
63	positive regulation of fatty acid transport (GO:2000193)	2.62702880
64	serotonin metabolic process (GO:0042428)	2.61940342
65	L-fucose catabolic process (GO:0042355)	2.60384963
66	fucose catabolic process (GO:0019317)	2.60384963
67	L-fucose metabolic process (GO:0042354)	2.60384963
68	adaptation of signaling pathway (GO:0023058)	2.60243677
69	regulation of collateral sprouting (GO:0048670)	2.57040523
70	indole-containing compound metabolic process (GO:0042430)	2.56572602
71	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.56297480
72	endoderm formation (GO:0001706)	2.54931953
73	regulation of female receptivity (GO:0045924)	2.54384823
74	regulation of synapse maturation (GO:0090128)	2.53645471
75	otic vesicle formation (GO:0030916)	2.53410186
76	membrane depolarization during action potential (GO:0086010)	2.51652836
77	lung morphogenesis (GO:0060425)	2.51262634
78	positive regulation of T cell apoptotic process (GO:0070234)	2.49942756
79	positive regulation of cardiac muscle cell differentiation (GO:2000727)	2.49598832
80	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.48724525
81	ATP synthesis coupled proton transport (GO:0015986)	2.48724525
82	negative regulation of astrocyte differentiation (GO:0048712)	2.47550139
83	reflex (GO:0060004)	2.47350105
84	negative regulation of appetite (GO:0032099)	2.47277677
85	negative regulation of response to food (GO:0032096)	2.47277677
86	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.47269257
87	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.47269257
88	regulation of action potential (GO:0098900)	2.47116490
89	negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)	2.46306840
90	regulation of phospholipid biosynthetic process (GO:0071071)	2.46169452
91	negative regulation of T cell differentiation in thymus (GO:0033085)	2.45691410
92	regulation of membrane repolarization (GO:0060306)	2.45061192
93	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.37239250
94	regulation of transcription regulatory region DNA binding (GO:2000677)	2.36783997
95	DNA methylation involved in gamete generation (GO:0043046)	2.35850635
96	positive regulation of icosanoid secretion (GO:0032305)	2.35705728
97	retinal ganglion cell axon guidance (GO:0031290)	2.35176121
98	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.35108061
99	spinal cord development (GO:0021510)	2.34689206
100	GPI anchor metabolic process (GO:0006505)	2.33907941

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.44680207
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.35778562
3	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.96755662
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.73981474
5	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.58583943
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.40874971
7	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.40537110
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.39086594
9	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.34711157
10	VDR_22108803_ChIP-Seq_LS180_Human	2.32714257
11	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.19667090
12	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.12693117
13	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.08959886
14	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.08823002
15	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.04344025
16	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.97204253
17	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.91891556
18	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.89931933
19	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.84659732
20	EWS_26573619_Chip-Seq_HEK293_Human	1.82494815
21	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.78660799
22	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.77254465
23	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.71271997
24	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.71117735
25	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.67660459
26	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.67020021
27	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.66560708
28	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.66020866
29	REST_21632747_ChIP-Seq_MESCs_Mouse	1.63880275
30	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.60501745
31	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.60501745
32	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.57620496
33	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.57493311
34	IRF1_19129219_ChIP-ChIP_H3396_Human	1.56480997
35	RNF2_27304074_Chip-Seq_NSC_Mouse	1.53293449
36	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.53068759
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.52918814
38	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.51248973
39	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.46199013
40	IGF1R_20145208_ChIP-Seq_DFB_Human	1.45149867
41	* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.42870418
42	FUS_26573619_Chip-Seq_HEK293_Human	1.40959136
43	P300_19829295_ChIP-Seq_ESCs_Human	1.39909097
44	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.39555798
45	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.39021712
46	MYC_18940864_ChIP-ChIP_HL60_Human	1.37812854
47	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.32568553
48	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.30367303
49	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.28576043
50	BCAT_22108803_ChIP-Seq_LS180_Human	1.27243013
51	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.26737057
52	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.24415145
53	ER_23166858_ChIP-Seq_MCF-7_Human	1.24373351
54	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.22276975
55	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.21498469
56	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.18097277
57	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.17448272
58	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.17311841
59	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.15890175
60	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.15712343
61	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.15256848
62	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.11025872
63	NCOR_22424771_ChIP-Seq_293T_Human	1.10924060
64	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.10593577
65	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.10036412
66	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.09865459
67	TP53_22573176_ChIP-Seq_HFKS_Human	1.09299050
68	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.05846873
69	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.05767727
70	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.04161703
71	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.04161703
72	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.03377377
73	ERA_21632823_ChIP-Seq_H3396_Human	1.02840050
74	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02463525
75	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.02463525
76	DROSHA_22980978_ChIP-Seq_HELA_Human	1.02109152
77	TAF15_26573619_Chip-Seq_HEK293_Human	1.01323464
78	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.01306004
79	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.00851493
80	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.00653862
81	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.00537558
82	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.00457934
83	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.98059057
84	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97618125
85	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.95972490
86	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.95148587
87	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.94401244
88	NANOG_20526341_ChIP-Seq_ESCs_Human	0.93319094
89	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.92955348
90	TAF2_19829295_ChIP-Seq_ESCs_Human	0.92114979
91	TCF4_23295773_ChIP-Seq_U87_Human	0.92037091
92	STAT3_23295773_ChIP-Seq_U87_Human	0.91432706
93	SOX2_19829295_ChIP-Seq_ESCs_Human	0.91263450
94	NANOG_19829295_ChIP-Seq_ESCs_Human	0.91263450
95	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.90073675
96	CBP_20019798_ChIP-Seq_JUKART_Human	0.90073675
97	AR_25329375_ChIP-Seq_VCAP_Human	0.89107786
98	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.88876633
99	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.88135213
100	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.87373616

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005646_abnormal_pituitary_gland	2.99626466
2	MP0006292_abnormal_olfactory_placode	2.80883022
3	MP0004885_abnormal_endolymph	2.72099118
4	MP0002160_abnormal_reproductive_system	2.65765479
5	MP0001968_abnormal_touch/_nociception	2.38356461
6	MP0002138_abnormal_hepatobiliary_system	2.35749912
7	MP0005389_reproductive_system_phenotype	2.23976681
8	MP0002837_dystrophic_cardiac_calcinosis	2.23535746
9	MP0000049_abnormal_middle_ear	2.19359501
10	MP0003646_muscle_fatigue	2.17432218
11	MP0008877_abnormal_DNA_methylation	2.09166933
12	MP0004142_abnormal_muscle_tone	2.05258516
13	MP0000631_abnormal_neuroendocrine_gland	2.04219180
14	MP0002272_abnormal_nervous_system	1.99483753
15	MP0002653_abnormal_ependyma_morphology	1.99457471
16	MP0002102_abnormal_ear_morphology	1.92614396
17	MP0006072_abnormal_retinal_apoptosis	1.91517445
18	MP0008872_abnormal_physiological_respon	1.85764063
19	MP0002736_abnormal_nociception_after	1.84371924
20	MP0004145_abnormal_muscle_electrophysio	1.82005005
21	MP0005551_abnormal_eye_electrophysiolog	1.81849172
22	MP0009745_abnormal_behavioral_response	1.77057470
23	MP0001485_abnormal_pinna_reflex	1.75603631
24	MP0002163_abnormal_gland_morphology	1.75502561
25	MP0004133_heterotaxia	1.69485397
26	MP0005645_abnormal_hypothalamus_physiol	1.67852624
27	MP0003011_delayed_dark_adaptation	1.63433842
28	MP0002735_abnormal_chemical_nociception	1.62845372
29	MP0001440_abnormal_grooming_behavior	1.56189618
30	MP0005671_abnormal_response_to	1.52160059
31	MP0004134_abnormal_chest_morphology	1.45825731
32	MP0002064_seizures	1.45188330
33	MP0002733_abnormal_thermal_nociception	1.44692562
34	MP0005379_endocrine/exocrine_gland_phen	1.41056870
35	MP0000678_abnormal_parathyroid_gland	1.40382360
36	MP0001919_abnormal_reproductive_system	1.37301548
37	MP0002277_abnormal_respiratory_mucosa	1.37069270
38	MP0001970_abnormal_pain_threshold	1.35627340
39	MP0003635_abnormal_synaptic_transmissio	1.34935082
40	MP0004742_abnormal_vestibular_system	1.34692869
41	MP0001502_abnormal_circadian_rhythm	1.32317379
42	MP0001905_abnormal_dopamine_level	1.31686931
43	MP0002876_abnormal_thyroid_physiology	1.30625015
44	MP0009046_muscle_twitch	1.27959347
45	MP0009250_abnormal_appendicular_skeleto	1.26868251
46	MP0000026_abnormal_inner_ear	1.24449893
47	MP0002572_abnormal_emotion/affect_behav	1.23175370
48	MP0005253_abnormal_eye_physiology	1.22151511
49	MP0005084_abnormal_gallbladder_morpholo	1.21738744
50	MP0001486_abnormal_startle_reflex	1.21655975
51	MP0003283_abnormal_digestive_organ	1.19414322
52	MP0003195_calcinosis	1.17893058
53	MP0003880_abnormal_central_pattern	1.16039471
54	MP0002557_abnormal_social/conspecific_i	1.15151861
55	MP0003938_abnormal_ear_development	1.14656162
56	MP0002938_white_spotting	1.12554536
57	MP0006276_abnormal_autonomic_nervous	1.12244436
58	MP0002928_abnormal_bile_duct	1.11766032
59	MP0001963_abnormal_hearing_physiology	1.10322695
60	MP0003567_abnormal_fetal_cardiomyocyte	1.08205690
61	MP0002063_abnormal_learning/memory/cond	1.06952338
62	MP0002734_abnormal_mechanical_nocicepti	1.06422794
63	MP0004130_abnormal_muscle_cell	1.03695653
64	MP0003119_abnormal_digestive_system	1.01500222
65	MP0000685_abnormal_immune_system	1.00862046
66	MP0003787_abnormal_imprinting	0.98934190
67	MP0001348_abnormal_lacrimal_gland	0.94245128
68	MP0001986_abnormal_taste_sensitivity	0.93216543
69	MP0005174_abnormal_tail_pigmentation	0.92986802
70	MP0009379_abnormal_foot_pigmentation	0.92953630
71	MP0000372_irregular_coat_pigmentation	0.91130582
72	MP0002234_abnormal_pharynx_morphology	0.90936889
73	MP0002752_abnormal_somatic_nervous	0.90875285
74	MP0000613_abnormal_salivary_gland	0.88812294
75	MP0003879_abnormal_hair_cell	0.88462903
76	MP0005195_abnormal_posterior_eye	0.88364639
77	MP0002067_abnormal_sensory_capabilities	0.86936634
78	MP0003724_increased_susceptibility_to	0.86476396
79	MP0002184_abnormal_innervation	0.85714575
80	MP0009053_abnormal_anal_canal	0.84888399
81	MP0008875_abnormal_xenobiotic_pharmacok	0.83413636
82	MP0000569_abnormal_digit_pigmentation	0.83348722
83	MP0001501_abnormal_sleep_pattern	0.79753682
84	MP0004859_abnormal_synaptic_plasticity	0.79225437
85	MP0002932_abnormal_joint_morphology	0.78041307
86	MP0002249_abnormal_larynx_morphology	0.77413601
87	MP0001529_abnormal_vocalization	0.76685888
88	MP0008789_abnormal_olfactory_epithelium	0.75724227
89	MP0001764_abnormal_homeostasis	0.74276408
90	MP0000230_abnormal_systemic_arterial	0.74024323
91	MP0001188_hyperpigmentation	0.73416482
92	MP0009765_abnormal_xenobiotic_induced	0.73333124
93	MP0003638_abnormal_response/metabolism_	0.73083733
94	MP0003937_abnormal_limbs/digits/tail_de	0.72324474
95	MP0001873_stomach_inflammation	0.72081892
96	MP0004147_increased_porphyrin_level	0.68300875
97	MP0005410_abnormal_fertilization	0.66539495
98	MP0005386_behavior/neurological_phenoty	0.65918810
99	MP0004924_abnormal_behavior	0.65918810
100	MP0001765_abnormal_ion_homeostasis	0.65820284

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.80530637
2	Pendular nystagmus (HP:0012043)	3.74381899
3	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.69030164
4	Abolished electroretinogram (ERG) (HP:0000550)	3.64048274
5	Conjunctival hamartoma (HP:0100780)	3.57392015
6	Pancreatic fibrosis (HP:0100732)	3.53522407
7	Congenital stationary night blindness (HP:0007642)	3.47729369
8	True hermaphroditism (HP:0010459)	3.47282618
9	Abnormality of the proximal phalanges of the hand (HP:0009834)	3.39309044
10	Genetic anticipation (HP:0003743)	3.37658248
11	Abnormality of midbrain morphology (HP:0002418)	3.18885160
12	Molar tooth sign on MRI (HP:0002419)	3.18885160
13	Abnormal rod and cone electroretinograms (HP:0008323)	3.15986551
14	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	3.09933907
15	Progressive cerebellar ataxia (HP:0002073)	3.07050702
16	Abnormality of the middle phalanges of the toes (HP:0010183)	2.97284190
17	Asplenia (HP:0001746)	2.96544359
18	Nephronophthisis (HP:0000090)	2.95221254
19	Decreased central vision (HP:0007663)	2.93016459
20	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.87539935
21	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.85667073
22	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.85049810
23	Keratoconus (HP:0000563)	2.84730735
24	Increased corneal curvature (HP:0100692)	2.84730735
25	Hamartoma of the eye (HP:0010568)	2.84339573
26	Hypoplasia of the uterus (HP:0000013)	2.82518183
27	Furrowed tongue (HP:0000221)	2.73084369
28	Abnormal number of erythroid precursors (HP:0012131)	2.66490287
29	Abnormality of DNA repair (HP:0003254)	2.63611440
30	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.59769869
31	Short 1st metacarpal (HP:0010034)	2.59769869
32	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.59196341
33	Aplasia/hypoplasia of the uterus (HP:0008684)	2.51528146
34	Severe visual impairment (HP:0001141)	2.46753295
35	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.46444994
36	Attenuation of retinal blood vessels (HP:0007843)	2.46121740
37	Short femoral neck (HP:0100864)	2.41442855
38	Short hallux (HP:0010109)	2.40100182
39	Methylmalonic acidemia (HP:0002912)	2.39673756
40	Cystic liver disease (HP:0006706)	2.37978098
41	Abnormality of the renal medulla (HP:0100957)	2.34597964
42	Abnormality of cells of the erythroid lineage (HP:0012130)	2.31713253
43	Abnormality of the renal cortex (HP:0011035)	2.28463928
44	Type II lissencephaly (HP:0007260)	2.27798181
45	Mitochondrial inheritance (HP:0001427)	2.27760622
46	Congenital sensorineural hearing impairment (HP:0008527)	2.26973063
47	Aplasia/Hypoplasia of the hallux (HP:0008362)	2.26282289
48	Congenital, generalized hypertrichosis (HP:0004540)	2.24964745
49	Abnormality of the 1st metacarpal (HP:0010009)	2.24458612
50	Sclerocornea (HP:0000647)	2.22905154
51	Morphological abnormality of the middle ear (HP:0008609)	2.21782745
52	Gaze-evoked nystagmus (HP:0000640)	2.20776169
53	3-Methylglutaconic aciduria (HP:0003535)	2.20675149
54	Agitation (HP:0000713)	2.20022905
55	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.19049080
56	Bone cyst (HP:0012062)	2.14230762
57	Male pseudohermaphroditism (HP:0000037)	2.14136768
58	Short tibia (HP:0005736)	2.13114365
59	Abnormality of the nasal septum (HP:0000419)	2.13072944
60	Bony spicule pigmentary retinopathy (HP:0007737)	2.12426661
61	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	2.12069589
62	Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)	2.11789202
63	Aplasia/Hypoplasia of the patella (HP:0006498)	2.08387217
64	Meningioma (HP:0002858)	2.08126209
65	Hepatocellular necrosis (HP:0001404)	2.04833291
66	Septo-optic dysplasia (HP:0100842)	2.03564541
67	Chronic hepatic failure (HP:0100626)	2.02368640
68	Fibular aplasia (HP:0002990)	2.02318786
69	Methylmalonic aciduria (HP:0012120)	2.02000100
70	Hypoplastic pelvis (HP:0008839)	2.01696237
71	Anomalous pulmonary venous return (HP:0010772)	1.99759951
72	Goiter (HP:0000853)	1.98928345
73	Chorioretinal atrophy (HP:0000533)	1.98491479
74	Absent/shortened dynein arms (HP:0200106)	1.98463497
75	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.98463497
76	Acute necrotizing encephalopathy (HP:0006965)	1.97256528
77	Mesomelia (HP:0003027)	1.96482688
78	Increased CSF lactate (HP:0002490)	1.95921988
79	Adactyly (HP:0009776)	1.94485920
80	Aplasia/Hypoplasia involving the pelvis (HP:0009103)	1.92510993
81	Abnormality of the renal collecting system (HP:0004742)	1.89206877
82	Concave nail (HP:0001598)	1.87961127
83	Small hand (HP:0200055)	1.87498764
84	Medial flaring of the eyebrow (HP:0010747)	1.87126970
85	Synostosis of carpal bones (HP:0005048)	1.86702615
86	Hypoplasia of the ulna (HP:0003022)	1.81056423
87	Anencephaly (HP:0002323)	1.80541737
88	Clumsiness (HP:0002312)	1.80203512
89	IgG deficiency (HP:0004315)	1.79218702
90	Short 4th metacarpal (HP:0010044)	1.78987244
91	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	1.78987244
92	Tubular atrophy (HP:0000092)	1.78603265
93	Polydipsia (HP:0001959)	1.78393793
94	Abnormal drinking behavior (HP:0030082)	1.78393793
95	Prostate neoplasm (HP:0100787)	1.78054981
96	Visual hallucinations (HP:0002367)	1.76731619
97	Adrenal hypoplasia (HP:0000835)	1.76721075
98	Abnormality of the 4th metacarpal (HP:0010012)	1.76279188
99	Megalencephaly (HP:0001355)	1.74410151
100	Aplasia/Hypoplasia of the fibula (HP:0006492)	1.74142229

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ADRBK2	3.68109562
2	FRK	3.59851486
3	GRK1	3.30771032
4	TAOK3	2.78078378
5	VRK2	2.69355007
6	NUAK1	2.48196748
7	TAF1	2.45977234
8	PINK1	2.35438879
9	MAP4K2	2.28830149
10	BCKDK	2.24673253
11	TXK	2.21433311
12	TLK1	2.15475781
13	BMPR1B	1.86064347
14	ZAK	1.77630493
15	PRKD2	1.64019310
16	WNK3	1.60125353
17	IKBKB	1.53326685
18	GRK7	1.53086787
19	DYRK2	1.51505015
20	MAPK13	1.49112627
21	WNK4	1.47513440
22	VRK1	1.37115296
23	GRK5	1.36756656
24	INSRR	1.31720799
25	NME2	1.31245418
26	TNIK	1.26559653
27	ADRBK1	1.26215983
28	DAPK2	1.25168410
29	CSNK1G2	1.24559140
30	RPS6KA6	1.18653108
31	CSNK1G3	1.15945646
32	MAPKAPK3	1.11717458
33	CASK	1.08183350
34	TIE1	1.04886766
35	MAPKAPK5	1.03198863
36	PRKCG	0.99249189
37	CSNK1G1	0.95666253
38	GRK6	0.93420548
39	CSNK1A1L	0.93085299
40	SGK2	0.90925379
41	KIT	0.90440505
42	STK16	0.90131755
43	PLK2	0.89378301
44	PAK3	0.89058996
45	DYRK3	0.88660858
46	TEC	0.88614825
47	PKN1	0.88364704
48	MAP4K1	0.87310956
49	MAP3K4	0.86485893
50	RPS6KL1	0.86148697
51	RPS6KC1	0.86148697
52	MAP2K6	0.81760685
53	ACVR1B	0.81431617
54	PRKCE	0.80073446
55	ABL2	0.79082844
56	MAP2K7	0.78836015
57	NTRK2	0.77221438
58	SIK2	0.74769483
59	TNK2	0.74321189
60	SGK223	0.74086096
61	SGK494	0.74086096
62	MAPK15	0.72658139
63	PHKG1	0.72322527
64	PHKG2	0.72322527
65	HIPK2	0.70931984
66	CSNK1A1	0.68422224
67	SYK	0.68300480
68	PRKACA	0.67451592
69	PRKCQ	0.66730991
70	RPS6KA2	0.66478586
71	PTK2B	0.63231955
72	MAP2K2	0.62328411
73	STK11	0.62014284
74	CDK19	0.61564323
75	AURKA	0.60914479
76	CAMK2A	0.60282669
77	MARK1	0.56814118
78	PRKCH	0.56802935
79	NEK9	0.56681366
80	FLT3	0.56245235
81	OXSR1	0.55738464
82	CAMKK2	0.55508934
83	RPS6KA5	0.52638150
84	LYN	0.52370376
85	PRKCI	0.51640504
86	MUSK	0.50664249
87	IKBKE	0.50417374
88	ITK	0.47194058
89	NTRK3	0.46893129
90	PRKCA	0.46671756
91	SGK3	0.46610013
92	CAMK1	0.46542208
93	MATK	0.45147275
94	CAMK2B	0.43874155
95	PRKAA1	0.41956025
96	DAPK3	0.41282649
97	CDK9	0.40330166
98	PIM2	0.39485498
99	DAPK1	0.39383940
100	ERBB2	0.38457197

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.86459984
2	Oxidative phosphorylation_Homo sapiens_hsa00190	2.62200427
3	Phototransduction_Homo sapiens_hsa04744	2.57756466
4	Nicotine addiction_Homo sapiens_hsa05033	2.51801672
5	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.50100692
6	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.20854070
7	Sulfur metabolism_Homo sapiens_hsa00920	2.18638814
8	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.17390461
9	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.00443391
10	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.94703718
11	Parkinsons disease_Homo sapiens_hsa05012	1.94619085
12	Linoleic acid metabolism_Homo sapiens_hsa00591	1.82753096
13	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.81685677
14	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.78891328
15	Morphine addiction_Homo sapiens_hsa05032	1.78613534
16	Homologous recombination_Homo sapiens_hsa03440	1.72310830
17	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.68917162
18	Nitrogen metabolism_Homo sapiens_hsa00910	1.64653627
19	Ribosome_Homo sapiens_hsa03010	1.64031464
20	Sulfur relay system_Homo sapiens_hsa04122	1.60637537
21	Primary immunodeficiency_Homo sapiens_hsa05340	1.53821274
22	Alzheimers disease_Homo sapiens_hsa05010	1.44839482
23	Cardiac muscle contraction_Homo sapiens_hsa04260	1.42696200
24	Chemical carcinogenesis_Homo sapiens_hsa05204	1.41357112
25	RNA polymerase_Homo sapiens_hsa03020	1.36205727
26	Olfactory transduction_Homo sapiens_hsa04740	1.35891574
27	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.35439739
28	Selenocompound metabolism_Homo sapiens_hsa00450	1.33058393
29	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.32015440
30	Asthma_Homo sapiens_hsa05310	1.28351231
31	Taste transduction_Homo sapiens_hsa04742	1.28271141
32	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.26687053
33	Retinol metabolism_Homo sapiens_hsa00830	1.26601231
34	Insulin secretion_Homo sapiens_hsa04911	1.24283769
35	Ether lipid metabolism_Homo sapiens_hsa00565	1.23862581
36	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.23686671
37	Protein export_Homo sapiens_hsa03060	1.20008347
38	Huntingtons disease_Homo sapiens_hsa05016	1.18398988
39	Tryptophan metabolism_Homo sapiens_hsa00380	1.17001586
40	Circadian entrainment_Homo sapiens_hsa04713	1.16964705
41	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.16824387
42	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.16034263
43	Basal transcription factors_Homo sapiens_hsa03022	1.12905309
44	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.11758674
45	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.10549678
46	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.07611431
47	GABAergic synapse_Homo sapiens_hsa04727	1.06287474
48	Glutamatergic synapse_Homo sapiens_hsa04724	1.01735300
49	Serotonergic synapse_Homo sapiens_hsa04726	1.01332853
50	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.98383792
51	Glycerolipid metabolism_Homo sapiens_hsa00561	0.96262217
52	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.95534789
53	Fanconi anemia pathway_Homo sapiens_hsa03460	0.94460484
54	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.94245653
55	Butanoate metabolism_Homo sapiens_hsa00650	0.91637445
56	Collecting duct acid secretion_Homo sapiens_hsa04966	0.90982605
57	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.85861735
58	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.83493739
59	Calcium signaling pathway_Homo sapiens_hsa04020	0.83004683
60	Caffeine metabolism_Homo sapiens_hsa00232	0.80800313
61	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.78060630
62	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.76895123
63	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.75433362
64	Cholinergic synapse_Homo sapiens_hsa04725	0.75109816
65	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.74992994
66	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.73823978
67	Salivary secretion_Homo sapiens_hsa04970	0.71939061
68	Gastric acid secretion_Homo sapiens_hsa04971	0.71627732
69	RNA degradation_Homo sapiens_hsa03018	0.70526027
70	Melanoma_Homo sapiens_hsa05218	0.69506519
71	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.68736046
72	Basal cell carcinoma_Homo sapiens_hsa05217	0.67972014
73	One carbon pool by folate_Homo sapiens_hsa00670	0.67144594
74	Peroxisome_Homo sapiens_hsa04146	0.66581291
75	Rheumatoid arthritis_Homo sapiens_hsa05323	0.63433460
76	Renin secretion_Homo sapiens_hsa04924	0.63189599
77	Regulation of autophagy_Homo sapiens_hsa04140	0.63030984
78	Type I diabetes mellitus_Homo sapiens_hsa04940	0.62941703
79	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.62663610
80	Allograft rejection_Homo sapiens_hsa05330	0.59131332
81	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.58399883
82	Dopaminergic synapse_Homo sapiens_hsa04728	0.56828635
83	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.55486316
84	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.55079574
85	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.54645973
86	Cocaine addiction_Homo sapiens_hsa05030	0.53494371
87	Graft-versus-host disease_Homo sapiens_hsa05332	0.52989004
88	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.51674780
89	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.51316827
90	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.50890418
91	MAPK signaling pathway_Homo sapiens_hsa04010	0.47426221
92	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.46173765
93	Nucleotide excision repair_Homo sapiens_hsa03420	0.43854322
94	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.43474382
95	cAMP signaling pathway_Homo sapiens_hsa04024	0.42438875
96	ABC transporters_Homo sapiens_hsa02010	0.42382994
97	Fat digestion and absorption_Homo sapiens_hsa04975	0.42013145
98	Metabolic pathways_Homo sapiens_hsa01100	0.41755552
99	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.39957810
100	Amphetamine addiction_Homo sapiens_hsa05031	0.39125091

ZNF414

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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