ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	gamma-aminobutyric acid transport (GO:0015812)	4.30645251
2	response to pheromone (GO:0019236)	4.12722832
3	pyrimidine nucleobase catabolic process (GO:0006208)	3.87755474
4	presynaptic membrane assembly (GO:0097105)	3.71890222
5	behavioral response to nicotine (GO:0035095)	3.63074503
6	presynaptic membrane organization (GO:0097090)	3.61475297
7	protein polyglutamylation (GO:0018095)	3.54518899
8	neuron cell-cell adhesion (GO:0007158)	3.54238977
9	protein localization to cilium (GO:0061512)	3.51450982
10	otic vesicle formation (GO:0030916)	3.37020893
11	intraciliary transport (GO:0042073)	3.30534650
12	regulation of cilium movement (GO:0003352)	3.24472672
13	nucleobase catabolic process (GO:0046113)	3.23438168
14	nonmotile primary cilium assembly (GO:0035058)	3.21551926
15	regulation of action potential (GO:0098900)	3.12658666
16	platelet dense granule organization (GO:0060155)	3.02505344
17	proline transport (GO:0015824)	2.95804317
18	transmission of nerve impulse (GO:0019226)	2.95360289
19	vocalization behavior (GO:0071625)	2.94341225
20	retinal cone cell development (GO:0046549)	2.93412294
21	epithelial cilium movement (GO:0003351)	2.92567671
22	cilium morphogenesis (GO:0060271)	2.88174469
23	protein complex biogenesis (GO:0070271)	2.87694063
24	neuronal action potential propagation (GO:0019227)	2.85154671
25	postsynaptic membrane organization (GO:0001941)	2.84080467
26	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.82634604
27	resolution of meiotic recombination intermediates (GO:0000712)	2.80807954
28	DNA double-strand break processing (GO:0000729)	2.79364154
29	chaperone-mediated protein transport (GO:0072321)	2.78946354
30	cellular ketone body metabolic process (GO:0046950)	2.77623282
31	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.77345934
32	C4-dicarboxylate transport (GO:0015740)	2.74558341
33	cilium organization (GO:0044782)	2.74327994
34	retinal ganglion cell axon guidance (GO:0031290)	2.73852515
35	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.72447717
36	kidney morphogenesis (GO:0060993)	2.71981124
37	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.71324073
38	inner ear receptor stereocilium organization (GO:0060122)	2.70716385
39	axoneme assembly (GO:0035082)	2.69709501
40	protein localization to synapse (GO:0035418)	2.69681470
41	cilium assembly (GO:0042384)	2.69299709
42	somite rostral/caudal axis specification (GO:0032525)	2.67602572
43	mitochondrial respiratory chain complex assembly (GO:0033108)	2.64940062
44	regulation of microtubule-based movement (GO:0060632)	2.63985180
45	sequestering of actin monomers (GO:0042989)	2.63130956
46	neuron recognition (GO:0008038)	2.61541512
47	DNA integration (GO:0015074)	2.60913408
48	axonal fasciculation (GO:0007413)	2.60099139
49	regulation of meiosis I (GO:0060631)	2.59967997
50	glycosphingolipid biosynthetic process (GO:0006688)	2.59411214
51	synapse assembly (GO:0007416)	2.58858537
52	dendritic spine morphogenesis (GO:0060997)	2.56767695
53	limb bud formation (GO:0060174)	2.55651432
54	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.55082175
55	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.53591722
56	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.51307489
57	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.51307489
58	NADH dehydrogenase complex assembly (GO:0010257)	2.51307489
59	cilium movement (GO:0003341)	2.51245800
60	seminiferous tubule development (GO:0072520)	2.49714273
61	L-fucose catabolic process (GO:0042355)	2.49422655
62	fucose catabolic process (GO:0019317)	2.49422655
63	L-fucose metabolic process (GO:0042354)	2.49422655
64	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.48362944
65	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.47483779
66	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.45872286
67	positive regulation of mitochondrial fission (GO:0090141)	2.45794539
68	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.45260560
69	respiratory chain complex IV assembly (GO:0008535)	2.44886502
70	protein K11-linked deubiquitination (GO:0035871)	2.44337221
71	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.44287013
72	preassembly of GPI anchor in ER membrane (GO:0016254)	2.43932442
73	ketone body metabolic process (GO:1902224)	2.42759315
74	neurofilament cytoskeleton organization (GO:0060052)	2.41505842
75	regulation of feeding behavior (GO:0060259)	2.41418940
76	histone H2A acetylation (GO:0043968)	2.40458364
77	water-soluble vitamin biosynthetic process (GO:0042364)	2.40397742
78	piRNA metabolic process (GO:0034587)	2.39865134
79	negative regulation of mast cell activation (GO:0033004)	2.39605413
80	establishment of mitochondrion localization (GO:0051654)	2.39344638
81	synaptic vesicle maturation (GO:0016188)	2.38463125
82	negative regulation of sodium ion transport (GO:0010766)	2.38354503
83	neuronal action potential (GO:0019228)	2.37266937
84	synapsis (GO:0007129)	2.35811250
85	cerebral cortex radially oriented cell migration (GO:0021799)	2.34120714
86	inositol phosphate catabolic process (GO:0071545)	2.33843451
87	protein-cofactor linkage (GO:0018065)	2.33782925
88	neural tube formation (GO:0001841)	2.33569240
89	mannosylation (GO:0097502)	2.31853234
90	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.31240521
91	somite development (GO:0061053)	2.31034721
92	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.29939163
93	short-term memory (GO:0007614)	2.29359496
94	behavioral response to ethanol (GO:0048149)	2.29216752
95	neuromuscular synaptic transmission (GO:0007274)	2.28666136
96	photoreceptor cell development (GO:0042461)	2.28118461
97	glutamate receptor signaling pathway (GO:0007215)	2.27674715
98	cytochrome complex assembly (GO:0017004)	2.27487194
99	spinal cord motor neuron differentiation (GO:0021522)	2.25720374
100	cullin deneddylation (GO:0010388)	2.25669327

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.45150908
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.24608099
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.03346301
4	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.71050638
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.55835942
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.53611051
7	TAF15_26573619_Chip-Seq_HEK293_Human	2.52886717
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.49362203
9	VDR_22108803_ChIP-Seq_LS180_Human	2.40810116
10	FUS_26573619_Chip-Seq_HEK293_Human	2.35292124
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.26900056
12	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.20384196
13	P300_19829295_ChIP-Seq_ESCs_Human	2.18486900
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.11680777
15	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.11336421
16	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.09971689
17	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.06611151
18	EWS_26573619_Chip-Seq_HEK293_Human	2.01321402
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.92977764
20	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.84669561
21	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.79347770
22	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.70626087
23	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.64410559
24	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.63265077
25	RNF2_27304074_Chip-Seq_NSC_Mouse	1.62840246
26	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.62154329
27	SMAD4_21799915_ChIP-Seq_A2780_Human	1.61572498
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.60536928
29	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.58685156
30	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.58434345
31	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.57948549
32	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.57707811
33	REST_21632747_ChIP-Seq_MESCs_Mouse	1.57496811
34	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.57379497
35	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.57174275
36	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.56908591
37	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.56563366
38	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.55657054
39	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.55536544
40	CBP_20019798_ChIP-Seq_JUKART_Human	1.54660799
41	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.54660799
42	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.52111925
43	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.51902270
44	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.50842284
45	BCAT_22108803_ChIP-Seq_LS180_Human	1.50070327
46	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.49469882
47	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.47749228
48	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.47020777
49	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.45879881
50	AR_25329375_ChIP-Seq_VCAP_Human	1.45560936
51	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.44366342
52	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.43082255
53	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.42744532
54	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.42744532
55	ER_23166858_ChIP-Seq_MCF-7_Human	1.40153665
56	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.37444657
57	STAT3_23295773_ChIP-Seq_U87_Human	1.36541407
58	TCF4_23295773_ChIP-Seq_U87_Human	1.31555256
59	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.31057582
60	TP53_22573176_ChIP-Seq_HFKS_Human	1.28683151
61	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.27226198
62	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.25453586
63	MYC_18940864_ChIP-ChIP_HL60_Human	1.25030658
64	RUNX2_22187159_ChIP-Seq_PCA_Human	1.23441375
65	ELK1_19687146_ChIP-ChIP_HELA_Human	1.22907411
66	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.22613824
67	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.19713392
68	IRF1_19129219_ChIP-ChIP_H3396_Human	1.19108926
69	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.18990148
70	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.18812173
71	TCF4_22108803_ChIP-Seq_LS180_Human	1.18174135
72	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.18066291
73	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.17503756
74	NANOG_19829295_ChIP-Seq_ESCs_Human	1.16651211
75	SOX2_19829295_ChIP-Seq_ESCs_Human	1.16651211
76	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.16586391
77	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.16173941
78	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.14786423
79	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.12746027
80	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.10884126
81	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.09628990
82	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.08813073
83	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.07419660
84	AR_21572438_ChIP-Seq_LNCaP_Human	1.06115618
85	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.06073490
86	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05715265
87	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.05354303
88	P53_22387025_ChIP-Seq_ESCs_Mouse	1.04533821
89	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.04088169
90	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.03788910
91	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.02176065
92	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.00517079
93	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99851129
94	* FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.99281672
95	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.98608998
96	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.96569457
97	JUN_21703547_ChIP-Seq_K562_Human	0.96408444
98	* FOXA1_25329375_ChIP-Seq_VCAP_Human	0.95266352
99	* FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.95266352
100	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.95073836

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	3.54070147
2	MP0008877_abnormal_DNA_methylation	2.98237744
3	MP0006292_abnormal_olfactory_placode	2.94249470
4	MP0002102_abnormal_ear_morphology	2.46462781
5	MP0001984_abnormal_olfaction	2.33709944
6	MP0002822_catalepsy	2.13675310
7	MP0003787_abnormal_imprinting	2.12439189
8	MP0000778_abnormal_nervous_system	2.11910655
9	MP0002653_abnormal_ependyma_morphology	2.11155906
10	MP0001968_abnormal_touch/_nociception	2.07141825
11	MP0006072_abnormal_retinal_apoptosis	2.05788144
12	MP0005423_abnormal_somatic_nervous	2.01606318
13	MP0001529_abnormal_vocalization	1.99515505
14	MP0008789_abnormal_olfactory_epithelium	1.96958895
15	MP0009745_abnormal_behavioral_response	1.96537525
16	MP0005551_abnormal_eye_electrophysiolog	1.92757864
17	MP0002736_abnormal_nociception_after	1.88720511
18	MP0004270_analgesia	1.88464549
19	MP0006276_abnormal_autonomic_nervous	1.86709483
20	MP0002272_abnormal_nervous_system	1.83720847
21	MP0009046_muscle_twitch	1.82804082
22	MP0001986_abnormal_taste_sensitivity	1.80609485
23	MP0004859_abnormal_synaptic_plasticity	1.79765041
24	MP0005394_taste/olfaction_phenotype	1.78340203
25	MP0005499_abnormal_olfactory_system	1.78340203
26	MP0002638_abnormal_pupillary_reflex	1.73023064
27	MP0003635_abnormal_synaptic_transmissio	1.72966435
28	MP0001486_abnormal_startle_reflex	1.69687847
29	MP0002734_abnormal_mechanical_nocicepti	1.63195241
30	MP0004133_heterotaxia	1.63144747
31	MP0005253_abnormal_eye_physiology	1.59039481
32	MP0002064_seizures	1.51678755
33	MP0002735_abnormal_chemical_nociception	1.50969852
34	MP0002572_abnormal_emotion/affect_behav	1.50026061
35	MP0003121_genomic_imprinting	1.49474840
36	MP0000631_abnormal_neuroendocrine_gland	1.49397646
37	MP0001188_hyperpigmentation	1.46946403
38	MP0003195_calcinosis	1.45872836
39	MP0003890_abnormal_embryonic-extraembry	1.43847447
40	MP0003122_maternal_imprinting	1.42418644
41	MP0002063_abnormal_learning/memory/cond	1.39379422
42	MP0005645_abnormal_hypothalamus_physiol	1.38265043
43	MP0002837_dystrophic_cardiac_calcinosis	1.38034703
44	MP0003136_yellow_coat_color	1.37989901
45	MP0004885_abnormal_endolymph	1.37488557
46	MP0002557_abnormal_social/conspecific_i	1.36467436
47	MP0005646_abnormal_pituitary_gland	1.34914301
48	MP0000516_abnormal_urinary_system	1.28261947
49	MP0005367_renal/urinary_system_phenotyp	1.28261947
50	MP0002277_abnormal_respiratory_mucosa	1.26748010
51	MP0004142_abnormal_muscle_tone	1.25505419
52	MP0008872_abnormal_physiological_respon	1.23177740
53	MP0008995_early_reproductive_senescence	1.23039192
54	MP0003119_abnormal_digestive_system	1.21781638
55	MP0004147_increased_porphyrin_level	1.20854636
56	MP0003011_delayed_dark_adaptation	1.20564535
57	MP0002233_abnormal_nose_morphology	1.20495960
58	MP0001485_abnormal_pinna_reflex	1.19671430
59	MP0002938_white_spotting	1.18572718
60	MP0004215_abnormal_myocardial_fiber	1.17052522
61	MP0001293_anophthalmia	1.16791801
62	MP0005386_behavior/neurological_phenoty	1.16454520
63	MP0004924_abnormal_behavior	1.16454520
64	MP0002184_abnormal_innervation	1.16171177
65	MP0002067_abnormal_sensory_capabilities	1.14966597
66	MP0001970_abnormal_pain_threshold	1.13089382
67	MP0000955_abnormal_spinal_cord	1.11715038
68	MP0003718_maternal_effect	1.11057663
69	MP0002234_abnormal_pharynx_morphology	1.11028241
70	MP0002752_abnormal_somatic_nervous	1.08018417
71	MP0005084_abnormal_gallbladder_morpholo	1.06914940
72	MP0002882_abnormal_neuron_morphology	1.05902778
73	MP0001501_abnormal_sleep_pattern	1.05511562
74	MP0003137_abnormal_impulse_conducting	1.01037045
75	MP0003938_abnormal_ear_development	1.00801258
76	MP0002751_abnormal_autonomic_nervous	1.00547944
77	MP0001177_atelectasis	0.99867395
78	MP0000372_irregular_coat_pigmentation	0.99756403
79	MP0000026_abnormal_inner_ear	0.98851051
80	MP0001299_abnormal_eye_distance/	0.98459814
81	MP0000049_abnormal_middle_ear	0.98297865
82	MP0002733_abnormal_thermal_nociception	0.96721193
83	MP0004742_abnormal_vestibular_system	0.95930779
84	MP0003646_muscle_fatigue	0.95169384
85	MP0001905_abnormal_dopamine_level	0.94025909
86	MP0005195_abnormal_posterior_eye	0.93333962
87	MP0002090_abnormal_vision	0.93073304
88	MP0009697_abnormal_copulation	0.92819704
89	MP0003698_abnormal_male_reproductive	0.91118757
90	MP0004085_abnormal_heartbeat	0.90528506
91	MP0005410_abnormal_fertilization	0.89553736
92	MP0001963_abnormal_hearing_physiology	0.88576912
93	MP0004043_abnormal_pH_regulation	0.87970779
94	MP0000427_abnormal_hair_cycle	0.86712333
95	MP0001502_abnormal_circadian_rhythm	0.86627468
96	MP0003937_abnormal_limbs/digits/tail_de	0.85283071
97	MP0003567_abnormal_fetal_cardiomyocyte	0.84314614
98	MP0002160_abnormal_reproductive_system	0.83944631
99	MP0002152_abnormal_brain_morphology	0.82386033
100	MP0003861_abnormal_nervous_system	0.80629153

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Medial flaring of the eyebrow (HP:0010747)	3.66047454
2	Pancreatic fibrosis (HP:0100732)	3.64837851
3	True hermaphroditism (HP:0010459)	3.63853614
4	Gait imbalance (HP:0002141)	3.49209756
5	Pancreatic cysts (HP:0001737)	3.45819473
6	Abnormality of midbrain morphology (HP:0002418)	3.35182522
7	Molar tooth sign on MRI (HP:0002419)	3.35182522
8	Congenital primary aphakia (HP:0007707)	3.25698152
9	Hyperventilation (HP:0002883)	3.19739753
10	Nephronophthisis (HP:0000090)	3.19256422
11	Nephrogenic diabetes insipidus (HP:0009806)	3.10630583
12	Genital tract atresia (HP:0001827)	2.97652908
13	Methylmalonic acidemia (HP:0002912)	2.94234817
14	Vaginal atresia (HP:0000148)	2.84803511
15	Chronic hepatic failure (HP:0100626)	2.75631799
16	Abnormality of the renal medulla (HP:0100957)	2.63268055
17	Type II lissencephaly (HP:0007260)	2.57541885
18	Atonic seizures (HP:0010819)	2.52072101
19	Focal motor seizures (HP:0011153)	2.50682614
20	Febrile seizures (HP:0002373)	2.48529856
21	Broad-based gait (HP:0002136)	2.46963643
22	Colon cancer (HP:0003003)	2.41823823
23	Septo-optic dysplasia (HP:0100842)	2.41599069
24	Lissencephaly (HP:0001339)	2.40152715
25	Abnormality of the renal cortex (HP:0011035)	2.39619620
26	Retinal dysplasia (HP:0007973)	2.36331009
27	Renal cortical cysts (HP:0000803)	2.34573460
28	Methylmalonic aciduria (HP:0012120)	2.33624673
29	Focal seizures (HP:0007359)	2.29517034
30	Cerebellar dysplasia (HP:0007033)	2.29445060
31	Limb dystonia (HP:0002451)	2.29383035
32	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.27002150
33	Inability to walk (HP:0002540)	2.25226744
34	Sclerocornea (HP:0000647)	2.23082232
35	Mitochondrial inheritance (HP:0001427)	2.22752675
36	Acute necrotizing encephalopathy (HP:0006965)	2.20368375
37	Optic nerve hypoplasia (HP:0000609)	2.20267834
38	Drooling (HP:0002307)	2.17891318
39	Postaxial hand polydactyly (HP:0001162)	2.14875220
40	Short tibia (HP:0005736)	2.14809491
41	Cystic liver disease (HP:0006706)	2.14131536
42	Poor coordination (HP:0002370)	2.12944186
43	Increased CSF lactate (HP:0002490)	2.10708450
44	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.10269256
45	Increased hepatocellular lipid droplets (HP:0006565)	2.09006050
46	Absent speech (HP:0001344)	2.07241679
47	Hepatocellular necrosis (HP:0001404)	2.07185596
48	Hypothermia (HP:0002045)	2.06134473
49	Abnormality of the labia minora (HP:0012880)	2.06072239
50	Male pseudohermaphroditism (HP:0000037)	2.05913885
51	Occipital encephalocele (HP:0002085)	2.05755683
52	Progressive macrocephaly (HP:0004481)	2.05536817
53	Myokymia (HP:0002411)	2.05390155
54	3-Methylglutaconic aciduria (HP:0003535)	2.04490860
55	Hyperglycinemia (HP:0002154)	2.03932861
56	Anencephaly (HP:0002323)	2.02352690
57	Postaxial foot polydactyly (HP:0001830)	2.01404063
58	Tubulointerstitial nephritis (HP:0001970)	2.00474781
59	Hemiparesis (HP:0001269)	1.99798424
60	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.99218376
61	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.99218376
62	Acute encephalopathy (HP:0006846)	1.99163412
63	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.99031607
64	Lipid accumulation in hepatocytes (HP:0006561)	1.97619408
65	Progressive inability to walk (HP:0002505)	1.96180610
66	Congenital stationary night blindness (HP:0007642)	1.94199602
67	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.93343894
68	Abnormal mitochondria in muscle tissue (HP:0008316)	1.91516563
69	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.90834362
70	Abnormality of alanine metabolism (HP:0010916)	1.90834362
71	Hyperalaninemia (HP:0003348)	1.90834362
72	Excessive salivation (HP:0003781)	1.90783176
73	Pachygyria (HP:0001302)	1.89965056
74	Abnormal rod and cone electroretinograms (HP:0008323)	1.89807665
75	Gaze-evoked nystagmus (HP:0000640)	1.88194403
76	Specific learning disability (HP:0001328)	1.87985407
77	Hepatic necrosis (HP:0002605)	1.85422943
78	Abnormal biliary tract physiology (HP:0012439)	1.85050181
79	Bile duct proliferation (HP:0001408)	1.85050181
80	Polyphagia (HP:0002591)	1.84696994
81	Intestinal atresia (HP:0011100)	1.84178861
82	Pendular nystagmus (HP:0012043)	1.84118878
83	Abolished electroretinogram (ERG) (HP:0000550)	1.83820761
84	Progressive cerebellar ataxia (HP:0002073)	1.83388179
85	Preaxial hand polydactyly (HP:0001177)	1.82772125
86	Epileptic encephalopathy (HP:0200134)	1.82524720
87	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.81853735
88	Absent/shortened dynein arms (HP:0200106)	1.81853735
89	Maternal diabetes (HP:0009800)	1.81283241
90	Broad foot (HP:0001769)	1.77867877
91	Increased corneal curvature (HP:0100692)	1.77163461
92	Keratoconus (HP:0000563)	1.77163461
93	Abnormality of the corticospinal tract (HP:0002492)	1.75184280
94	Dialeptic seizures (HP:0011146)	1.74930781
95	Bifid tongue (HP:0010297)	1.74119879
96	Congenital hepatic fibrosis (HP:0002612)	1.73872849
97	Abnormal respiratory epithelium morphology (HP:0012253)	1.70890760
98	Abnormal respiratory motile cilium morphology (HP:0005938)	1.70890760
99	Renal Fanconi syndrome (HP:0001994)	1.70853352
100	Decreased central vision (HP:0007663)	1.70000285

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.89482743
2	WNK3	2.86942350
3	FRK	2.82700730
4	MARK1	2.79312760
5	CASK	2.55854533
6	TRIM28	2.38647147
7	TNIK	2.38177837
8	MAPK13	2.35923443
9	INSRR	2.32043566
10	MAP3K4	2.29686740
11	BMPR1B	2.10598637
12	PINK1	2.06882114
13	BCR	2.01439135
14	ERBB3	1.95271211
15	PNCK	1.94484349
16	EPHA4	1.86327241
17	MAP2K7	1.83900812
18	ZAK	1.76727636
19	NUAK1	1.70537008
20	GRK1	1.65094633
21	DYRK2	1.53072706
22	PAK3	1.51512574
23	CDK19	1.45831676
24	VRK2	1.41501157
25	STK38L	1.39093125
26	CSNK1G2	1.36967422
27	ADRBK2	1.32657553
28	PLK2	1.26767308
29	AKT3	1.25135332
30	NTRK2	1.24017287
31	CSNK1G1	1.15601375
32	CSNK1G3	1.15274831
33	WNK4	1.14506956
34	VRK1	1.14456648
35	PRKCG	1.10105945
36	TAOK3	1.07054108
37	OXSR1	1.06457634
38	NTRK3	1.04601549
39	PRKCE	1.01077011
40	MINK1	0.98336266
41	BCKDK	0.97330772
42	DAPK2	0.96982592
43	STK16	0.95451847
44	STK39	0.92309398
45	ACVR1B	0.92219215
46	CSNK1A1L	0.91936820
47	CCNB1	0.91771545
48	PDK2	0.90188997
49	MKNK2	0.90123947
50	FGFR2	0.89517719
51	PLK4	0.89106562
52	UHMK1	0.86673034
53	PAK6	0.86475037
54	PHKG2	0.79908334
55	PHKG1	0.79908334
56	LIMK1	0.74077464
57	PLK3	0.73262950
58	DYRK1A	0.73160099
59	MST4	0.72565337
60	PRKD3	0.70783083
61	OBSCN	0.70180921
62	CDK5	0.69054206
63	CAMK2A	0.67773754
64	EIF2AK3	0.66716317
65	DYRK3	0.66145270
66	SGK494	0.64161936
67	SGK223	0.64161936
68	PKN1	0.63925760
69	TGFBR1	0.63859860
70	SGK2	0.62760295
71	MKNK1	0.60681248
72	TIE1	0.57635401
73	CDK3	0.53377166
74	CAMK1	0.50624735
75	CSNK1D	0.49902336
76	WEE1	0.49878650
77	IRAK2	0.49692153
78	LMTK2	0.49426204
79	PRKACA	0.49243465
80	ADRBK1	0.48448665
81	PRKCZ	0.47519954
82	PLK1	0.47411923
83	EPHB2	0.44166212
84	CSNK1A1	0.43878031
85	GRK5	0.42482496
86	PRKG1	0.40838586
87	IRAK1	0.39904937
88	SIK2	0.38583994
89	CAMK2D	0.38073916
90	MAP2K4	0.37915933
91	STK38	0.37405652
92	FER	0.36972447
93	CAMK2B	0.34560129
94	CSNK1E	0.33744528
95	PRKACB	0.33660775
96	MAPKAPK5	0.33647666
97	PBK	0.32029664
98	ATM	0.31859826
99	DYRK1B	0.27660315
100	PRKCA	0.27561872

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.11196720
2	Nicotine addiction_Homo sapiens_hsa05033	2.91334692
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.83602782
4	Protein export_Homo sapiens_hsa03060	2.47874168
5	Phototransduction_Homo sapiens_hsa04744	2.45874739
6	Parkinsons disease_Homo sapiens_hsa05012	2.33965713
7	Butanoate metabolism_Homo sapiens_hsa00650	2.12384750
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.08361580
9	Propanoate metabolism_Homo sapiens_hsa00640	1.98623608
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.84240436
11	Fatty acid elongation_Homo sapiens_hsa00062	1.78680121
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.77560412
13	Cardiac muscle contraction_Homo sapiens_hsa04260	1.74339565
14	Basal transcription factors_Homo sapiens_hsa03022	1.70431822
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.67210930
16	GABAergic synapse_Homo sapiens_hsa04727	1.65331343
17	Huntingtons disease_Homo sapiens_hsa05016	1.59917971
18	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.58699452
19	Alzheimers disease_Homo sapiens_hsa05010	1.52318521
20	Peroxisome_Homo sapiens_hsa04146	1.48632722
21	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.47737619
22	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.47227157
23	Taste transduction_Homo sapiens_hsa04742	1.44786299
24	Selenocompound metabolism_Homo sapiens_hsa00450	1.42881833
25	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.41980846
26	Circadian entrainment_Homo sapiens_hsa04713	1.41883697
27	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.38419789
28	Morphine addiction_Homo sapiens_hsa05032	1.37859224
29	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.35884867
30	Fanconi anemia pathway_Homo sapiens_hsa03460	1.35861248
31	RNA polymerase_Homo sapiens_hsa03020	1.34392105
32	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.33785455
33	Steroid biosynthesis_Homo sapiens_hsa00100	1.33350777
34	Olfactory transduction_Homo sapiens_hsa04740	1.31276661
35	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.26389646
36	Regulation of autophagy_Homo sapiens_hsa04140	1.24195385
37	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.23661949
38	RNA degradation_Homo sapiens_hsa03018	1.23553019
39	Collecting duct acid secretion_Homo sapiens_hsa04966	1.23104396
40	Glutamatergic synapse_Homo sapiens_hsa04724	1.20759876
41	Insulin secretion_Homo sapiens_hsa04911	1.20076829
42	Ether lipid metabolism_Homo sapiens_hsa00565	1.18312345
43	Linoleic acid metabolism_Homo sapiens_hsa00591	1.17692029
44	Dopaminergic synapse_Homo sapiens_hsa04728	1.16136774
45	Proteasome_Homo sapiens_hsa03050	1.11931396
46	Nitrogen metabolism_Homo sapiens_hsa00910	1.11005190
47	Amphetamine addiction_Homo sapiens_hsa05031	1.10658419
48	Circadian rhythm_Homo sapiens_hsa04710	1.06414877
49	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.01513148
50	beta-Alanine metabolism_Homo sapiens_hsa00410	0.97705793
51	Tryptophan metabolism_Homo sapiens_hsa00380	0.97172546
52	Homologous recombination_Homo sapiens_hsa03440	0.97005967
53	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.89170889
54	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.88988823
55	Cocaine addiction_Homo sapiens_hsa05030	0.88321689
56	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.84840056
57	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.82555823
58	Serotonergic synapse_Homo sapiens_hsa04726	0.82405856
59	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.79702686
60	Non-homologous end-joining_Homo sapiens_hsa03450	0.78785454
61	Oocyte meiosis_Homo sapiens_hsa04114	0.78216871
62	Salivary secretion_Homo sapiens_hsa04970	0.74519807
63	Fatty acid metabolism_Homo sapiens_hsa01212	0.74043998
64	Pyruvate metabolism_Homo sapiens_hsa00620	0.72086877
65	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.71251328
66	Calcium signaling pathway_Homo sapiens_hsa04020	0.71056337
67	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.70148100
68	Chemical carcinogenesis_Homo sapiens_hsa05204	0.68489504
69	Mismatch repair_Homo sapiens_hsa03430	0.63972904
70	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.62931605
71	Fatty acid degradation_Homo sapiens_hsa00071	0.61056896
72	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.60166373
73	Basal cell carcinoma_Homo sapiens_hsa05217	0.59348586
74	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.58674751
75	Metabolic pathways_Homo sapiens_hsa01100	0.57190889
76	Caffeine metabolism_Homo sapiens_hsa00232	0.56564402
77	Axon guidance_Homo sapiens_hsa04360	0.56294010
78	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.56010113
79	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.54952959
80	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.53803733
81	Retinol metabolism_Homo sapiens_hsa00830	0.53648216
82	Purine metabolism_Homo sapiens_hsa00230	0.53319751
83	Gastric acid secretion_Homo sapiens_hsa04971	0.52494240
84	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.50976250
85	RNA transport_Homo sapiens_hsa03013	0.50632943
86	Hippo signaling pathway_Homo sapiens_hsa04390	0.50359622
87	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.50221599
88	cAMP signaling pathway_Homo sapiens_hsa04024	0.48767806
89	Nucleotide excision repair_Homo sapiens_hsa03420	0.46193524
90	Cholinergic synapse_Homo sapiens_hsa04725	0.45174196
91	Long-term depression_Homo sapiens_hsa04730	0.44908777
92	Arginine and proline metabolism_Homo sapiens_hsa00330	0.44378735
93	Histidine metabolism_Homo sapiens_hsa00340	0.44061088
94	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.43796529
95	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.42017930
96	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.41993545
97	Wnt signaling pathway_Homo sapiens_hsa04310	0.41718028
98	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.40862130
99	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.40382286
100	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.39216672

ZNF415

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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