ZNF415P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of osteoblast proliferation (GO:0033690)9.50703977
2cellular response to thyroid hormone stimulus (GO:0097067)8.55485667
3granulocyte differentiation (GO:0030851)7.03080392
4negative regulation of bone mineralization (GO:0030502)6.31218494
5erythrocyte development (GO:0048821)6.29709385
6response to thyroid hormone (GO:0097066)5.93107794
7positive regulation by symbiont of host defense response (GO:0052509)5.54573373
8modulation by symbiont of host defense response (GO:0052031)5.54573373
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.54573373
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.54573373
11positive regulation by organism of defense response of other organism involved in symbiotic interact5.54573373
12modulation by symbiont of host immune response (GO:0052553)5.54573373
13positive regulation of mitochondrial calcium ion concentration (GO:0051561)5.52135747
14negative regulation of biomineral tissue development (GO:0070168)5.48417668
15negative regulation of transcription regulatory region DNA binding (GO:2000678)5.40879622
16microglial cell activation (GO:0001774)5.18863728
17positive regulation of insulin receptor signaling pathway (GO:0046628)5.17633537
18regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)5.16955459
19positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)5.16955459
20positive regulation of erythrocyte differentiation (GO:0045648)5.12639074
21platelet formation (GO:0030220)5.08065976
22detection of molecule of bacterial origin (GO:0032490)4.87339248
23negative regulation of mast cell activation (GO:0033004)4.77898282
24embryonic hemopoiesis (GO:0035162)4.70771955
25regulation of interferon-beta biosynthetic process (GO:0045357)4.59116686
26nuclear envelope reassembly (GO:0031468)4.41742743
27mitotic nuclear envelope reassembly (GO:0007084)4.41742743
28natural killer cell activation involved in immune response (GO:0002323)4.39073282
29positive regulation of interferon-alpha production (GO:0032727)4.29197635
30purine ribonucleotide transport (GO:0015868)4.28055935
31mitochondrial calcium ion transport (GO:0006851)4.27621907
32cilium or flagellum-dependent cell motility (GO:0001539)4.26556102
33macrophage activation involved in immune response (GO:0002281)4.22866478
34adenine nucleotide transport (GO:0051503)4.06735295
35positive regulation of cell cycle checkpoint (GO:1901978)4.05132524
36neutrophil mediated immunity (GO:0002446)4.04454597
37regulation of interferon-alpha production (GO:0032647)3.99261277
38negative regulation of gluconeogenesis (GO:0045721)3.99005296
39positive regulation of gamma-delta T cell activation (GO:0046645)3.85167139
40epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.76743427
41macrophage activation (GO:0042116)3.62773649
42regulation of erythrocyte differentiation (GO:0045646)3.58853610
43cell wall macromolecule catabolic process (GO:0016998)3.57909576
44positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.56247275
45monoubiquitinated protein deubiquitination (GO:0035520)3.54905310
46regulation of pigment cell differentiation (GO:0050932)3.54459773
47myeloid cell development (GO:0061515)3.52888943
48response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.50568944
49response to host immune response (GO:0052572)3.50568944
50regulation of MHC class I biosynthetic process (GO:0045343)3.50519233
51positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.49315942
52female mating behavior (GO:0060180)3.45864121
53positive regulation of cellular response to insulin stimulus (GO:1900078)3.45473423
54myeloid leukocyte mediated immunity (GO:0002444)3.40219486
55regulation of osteoblast proliferation (GO:0033688)3.36191707
56mannose metabolic process (GO:0006013)3.33003353
57outer ear morphogenesis (GO:0042473)3.32955200
58mitochondrial calcium ion homeostasis (GO:0051560)3.30880857
59protein targeting to vacuole (GO:0006623)3.29768583
60protein targeting to lysosome (GO:0006622)3.29768583
61establishment of protein localization to vacuole (GO:0072666)3.29768583
62mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.29284595
63N-terminal protein amino acid acetylation (GO:0006474)3.26876555
64histone H3-K36 demethylation (GO:0070544)3.26042210
65protein targeting to Golgi (GO:0000042)3.22200434
66establishment of protein localization to Golgi (GO:0072600)3.21794674
67dendritic cell differentiation (GO:0097028)3.21079422
68negative regulation of anoikis (GO:2000811)3.20056192
69negative regulation of protein localization to cell surface (GO:2000009)3.18916992
70cellular response to exogenous dsRNA (GO:0071360)3.18408296
71positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.17470932
72mitotic cell cycle arrest (GO:0071850)3.16587027
73positive regulation of B cell differentiation (GO:0045579)3.12048701
74positive regulation of interferon-beta production (GO:0032728)3.09712254
75regulation of B cell receptor signaling pathway (GO:0050855)3.08729683
76response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.08115277
77response to host (GO:0075136)3.08115277
78response to host defenses (GO:0052200)3.08115277
79iron ion import (GO:0097286)3.07401299
80centriole replication (GO:0007099)3.06937164
81regulation of mast cell degranulation (GO:0043304)3.06880779
82multicellular organismal reproductive behavior (GO:0033057)3.06268172
83regulation of gamma-delta T cell differentiation (GO:0045586)3.05646288
84regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.04018043
85regulation of mitotic spindle checkpoint (GO:1903504)3.04018043
86response to exogenous dsRNA (GO:0043330)3.03996747
87urinary tract smooth muscle contraction (GO:0014848)3.02132854
88purine nucleotide transport (GO:0015865)3.01567857
89regulation of acyl-CoA biosynthetic process (GO:0050812)3.01315092
90pore complex assembly (GO:0046931)2.99727866
91retrograde transport, vesicle recycling within Golgi (GO:0000301)2.99618571
92regulation of mast cell activation involved in immune response (GO:0033006)2.99305946
93cellular response to interferon-beta (GO:0035458)2.97142613
94cell wall macromolecule metabolic process (GO:0044036)2.92149221
95positive regulation of toll-like receptor signaling pathway (GO:0034123)2.91970869
96regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.88569344
97regulation of glycoprotein biosynthetic process (GO:0010559)2.88161401
98aerobic respiration (GO:0009060)2.85765412
99respiratory chain complex IV assembly (GO:0008535)2.84216071
100regulation of gamma-delta T cell activation (GO:0046643)2.81920877

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse4.96135019
2GATA1_22025678_ChIP-Seq_K562_Human4.35423164
3IRF8_22096565_ChIP-ChIP_GC-B_Human2.67656510
4IRF8_27001747_Chip-Seq_BMDM_Mouse2.49441525
5MYB_21317192_ChIP-Seq_ERMYB_Mouse2.20952505
6AR_21572438_ChIP-Seq_LNCaP_Human2.08252427
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.02419325
8GATA1_19941826_ChIP-Seq_K562_Human2.01336197
9VDR_24787735_ChIP-Seq_THP-1_Human2.00676313
10SCL_19346495_ChIP-Seq_HPC-7_Human1.97031837
11IRF8_21731497_ChIP-ChIP_J774_Mouse1.89349806
12FLI1_27457419_Chip-Seq_LIVER_Mouse1.87661064
13RUNX_20019798_ChIP-Seq_JUKART_Human1.80236436
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.75921785
15SPI1_23547873_ChIP-Seq_NB4_Human1.75451201
16TP53_16413492_ChIP-PET_HCT116_Human1.74629929
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.74452263
18SPI1_23127762_ChIP-Seq_K562_Human1.65024156
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.64954890
20EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.60527468
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.60185652
22GATA3_26560356_Chip-Seq_TH2_Human1.58223373
23IGF1R_20145208_ChIP-Seq_DFB_Human1.54307355
24SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52932295
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.51528132
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51302228
27POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.49415966
28TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49415966
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.48054539
30ER_23166858_ChIP-Seq_MCF-7_Human1.44180546
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.43830315
32CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.43488355
33SMRT_27268052_Chip-Seq_Bcells_Human1.42822804
34EZH2_27294783_Chip-Seq_NPCs_Mouse1.42814263
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42670074
36GATA2_19941826_ChIP-Seq_K562_Human1.41825541
37PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41620062
38ESR1_15608294_ChIP-ChIP_MCF-7_Human1.40558699
39CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.39737603
40STAT3_23295773_ChIP-Seq_U87_Human1.38037791
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35124848
42FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.34753864
43P300_19829295_ChIP-Seq_ESCs_Human1.33656860
44FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.32210395
45FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.31782681
46OCT4_21477851_ChIP-Seq_ESCs_Mouse1.30061186
47SALL4_18804426_ChIP-ChIP_XEN_Mouse1.28632259
48VDR_22108803_ChIP-Seq_LS180_Human1.28237394
49P53_22387025_ChIP-Seq_ESCs_Mouse1.25801495
50AR_25329375_ChIP-Seq_VCAP_Human1.25639417
51MYB_26560356_Chip-Seq_TH2_Human1.23166935
52SUZ12_18555785_Chip-Seq_ESCs_Mouse1.22730900
53PRDM14_20953172_ChIP-Seq_ESCs_Human1.21831083
54TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21606457
55EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20157921
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20100805
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20031340
58E2F1_18555785_Chip-Seq_ESCs_Mouse1.19474388
59CTCF_18555785_Chip-Seq_ESCs_Mouse1.19430519
60CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.19087497
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.18801818
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.17766667
63CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.16042406
64GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.15978988
65IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.15573099
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14924417
67TCF4_22108803_ChIP-Seq_LS180_Human1.13715436
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13238937
69EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13223119
70SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.12300945
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.12026074
72FLI1_21867929_ChIP-Seq_TH2_Mouse1.10400899
73FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10326677
74LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10210875
75AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.09539188
76SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.09276473
77CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09003639
78EWS_26573619_Chip-Seq_HEK293_Human1.08779773
79CMYC_18555785_Chip-Seq_ESCs_Mouse1.08515890
80CRX_20693478_ChIP-Seq_RETINA_Mouse1.08365508
81TCF4_23295773_ChIP-Seq_U87_Human1.08131893
82RUNX1_27457419_Chip-Seq_LIVER_Mouse1.07382370
83SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06513118
84GATA3_27048872_Chip-Seq_THYMUS_Human1.06429819
85RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.05680240
86PU_27001747_Chip-Seq_BMDM_Mouse1.05577482
87FOXM1_23109430_ChIP-Seq_U2OS_Human1.04715771
88SALL4_22934838_ChIP-ChIP_CD34+_Human1.03438050
89BRD4_27068464_Chip-Seq_AML-cells_Mouse1.02297535
90GATA2_21666600_ChIP-Seq_HMVEC_Human1.01979818
91CJUN_26792858_Chip-Seq_BT549_Human1.01021575
92NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00825732
93CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.00596948
94OCT4_18555785_Chip-Seq_ESCs_Mouse1.00278308
95STAT3_18555785_Chip-Seq_ESCs_Mouse0.99552142
96SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97740153
97FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97730797
98NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96710182
99GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96542337
100SALL1_21062744_ChIP-ChIP_HESCs_Human0.96335459

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002132_abnormal_respiratory_system7.74576596
2MP0000569_abnormal_digit_pigmentation5.05276758
3MP0001661_extended_life_span4.23250760
4MP0005397_hematopoietic_system_phenotyp3.95793377
5MP0001545_abnormal_hematopoietic_system3.95793377
6MP0003787_abnormal_imprinting3.25966554
7MP0005174_abnormal_tail_pigmentation3.01410547
8MP0000015_abnormal_ear_pigmentation2.86774758
9MP0006054_spinal_hemorrhage2.38524090
10MP0003724_increased_susceptibility_to2.35366286
11MP0004883_abnormal_blood_vessel2.19874199
12MP0001853_heart_inflammation2.12279816
13MP0003950_abnormal_plasma_membrane2.11083952
14MP0004885_abnormal_endolymph2.05081720
15MP0003656_abnormal_erythrocyte_physiolo2.01652634
16MP0009697_abnormal_copulation2.00618445
17MP0008872_abnormal_physiological_respon1.89903368
18MP0008057_abnormal_DNA_replication1.89021452
19MP0005409_darkened_coat_color1.81315343
20MP0000685_abnormal_immune_system1.77549097
21MP0004484_altered_response_of1.74168463
22MP0002736_abnormal_nociception_after1.64693356
23MP0008875_abnormal_xenobiotic_pharmacok1.64152723
24MP0005164_abnormal_response_to1.61533155
25MP0006082_CNS_inflammation1.59700555
26MP0001835_abnormal_antigen_presentation1.55968831
27MP0002837_dystrophic_cardiac_calcinosis1.53868829
28MP0010352_gastrointestinal_tract_polyps1.48042792
29MP0001188_hyperpigmentation1.46391106
30MP0009379_abnormal_foot_pigmentation1.44435380
31MP0004782_abnormal_surfactant_physiolog1.39458366
32MP0005360_urolithiasis1.38832284
33MP0003828_pulmonary_edema1.37822416
34MP0005171_absent_coat_pigmentation1.36288296
35MP0008877_abnormal_DNA_methylation1.27417780
36MP0002723_abnormal_immune_serum1.25909449
37MP0004147_increased_porphyrin_level1.25047924
38MP0002419_abnormal_innate_immunity1.23915689
39MP0002254_reproductive_system_inflammat1.22415762
40MP0001968_abnormal_touch/_nociception1.22145523
41MP0002095_abnormal_skin_pigmentation1.15761439
42MP0009764_decreased_sensitivity_to1.12603021
43MP0005464_abnormal_platelet_physiology1.09847684
44MP0009115_abnormal_fat_cell1.09256083
45MP0005167_abnormal_blood-brain_barrier1.08651792
46MP0001800_abnormal_humoral_immune1.08328093
47MP0006138_congestive_heart_failure1.06955268
48MP0000427_abnormal_hair_cycle1.06553980
49MP0002133_abnormal_respiratory_system1.03061642
50MP0005388_respiratory_system_phenotype1.03061642
51MP0002722_abnormal_immune_system1.01769278
52MP0003303_peritoneal_inflammation0.99824443
53MP0003763_abnormal_thymus_physiology0.97931146
54MP0002452_abnormal_antigen_presenting0.97556285
55MP0006036_abnormal_mitochondrial_physio0.95500161
56MP0005636_abnormal_mineral_homeostasis0.93348066
57MP0005000_abnormal_immune_tolerance0.93316569
58MP0005376_homeostasis/metabolism_phenot0.92720587
59MP0009785_altered_susceptibility_to0.90605429
60MP0002398_abnormal_bone_marrow0.90369032
61MP0000716_abnormal_immune_system0.88203685
62MP0005025_abnormal_response_to0.87913855
63MP0003646_muscle_fatigue0.86944099
64MP0008469_abnormal_protein_level0.86378370
65MP0005584_abnormal_enzyme/coenzyme_acti0.85139930
66MP0000689_abnormal_spleen_morphology0.84451545
67MP0003436_decreased_susceptibility_to0.84336975
68MP0005310_abnormal_salivary_gland0.84182161
69MP0004264_abnormal_extraembryonic_tissu0.81246066
70MP0002420_abnormal_adaptive_immunity0.80289395
71MP0008874_decreased_physiological_sensi0.78946859
72MP0002148_abnormal_hypersensitivity_rea0.78725542
73MP0001819_abnormal_immune_cell0.78608849
74MP0008770_decreased_survivor_rate0.78290133
75MP0001845_abnormal_inflammatory_respons0.75436173
76MP0000383_abnormal_hair_follicle0.74829366
77MP0000703_abnormal_thymus_morphology0.74800290
78MP0005387_immune_system_phenotype0.74660295
79MP0001790_abnormal_immune_system0.74660295
80MP0001915_intracranial_hemorrhage0.73720971
81MP0004142_abnormal_muscle_tone0.69746761
82MP0004084_abnormal_cardiac_muscle0.69638767
83MP0002429_abnormal_blood_cell0.68624455
84MP0002405_respiratory_system_inflammati0.66478815
85MP0000858_altered_metastatic_potential0.65616987
86MP0004043_abnormal_pH_regulation0.65159744
87MP0009278_abnormal_bone_marrow0.63714189
88MP0005253_abnormal_eye_physiology0.63201098
89MP0002177_abnormal_outer_ear0.61528693
90MP0001191_abnormal_skin_condition0.60063418
91MP0005647_abnormal_sex_gland0.59157452
92MP0003172_abnormal_lysosome_physiology0.58226422
93MP0003221_abnormal_cardiomyocyte_apopto0.57360750
94MP0004947_skin_inflammation0.54990358
95MP0000249_abnormal_blood_vessel0.54829365
96MP0005076_abnormal_cell_differentiation0.54151713
97MP0005075_abnormal_melanosome_morpholog0.53445691
98MP0001879_abnormal_lymphatic_vessel0.50733424
99MP0005395_other_phenotype0.50012995
100MP0003632_abnormal_nervous_system0.49800047

Predicted human phenotypes

RankGene SetZ-score
1Short middle phalanx of the 5th finger (HP:0004220)9.44123696
2Acanthocytosis (HP:0001927)7.90976745
3Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)5.88431659
4Petechiae (HP:0000967)5.42479152
5Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)5.33925031
6Hypoplastic iliac wings (HP:0002866)5.22882823
7Protruding tongue (HP:0010808)5.07869014
8Broad palm (HP:0001169)4.98966333
9Abnormality of the middle phalanx of the 5th finger (HP:0004219)4.87660915
10Polycythemia (HP:0001901)4.67732268
11Abnormality of the phalanges of the 5th finger (HP:0004213)4.48138858
12Prolonged bleeding time (HP:0003010)4.45296375
13Poikilocytosis (HP:0004447)4.37644737
14Absent/shortened dynein arms (HP:0200106)4.19155981
15Dynein arm defect of respiratory motile cilia (HP:0012255)4.19155981
16Short 5th finger (HP:0009237)4.18989283
17Facial hemangioma (HP:0000329)4.13758257
18Abnormality of the heme biosynthetic pathway (HP:0010472)4.04600737
19Brushfield spots (HP:0001088)3.99570892
20Abnormal platelet function (HP:0011869)3.87730867
21Impaired platelet aggregation (HP:0003540)3.87730867
22Aplasia/Hypoplasia of the 5th finger (HP:0006262)3.86212255
23Abnormality of dental color (HP:0011073)3.53483634
24Reticulocytosis (HP:0001923)3.51379054
25Complete atrioventricular canal defect (HP:0001674)3.48195465
26Rectal prolapse (HP:0002035)3.31143004
27Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.08920505
28Abnormality of the wing of the ilium (HP:0011867)2.70515292
29Hypoplastic ilia (HP:0000946)2.62750044
30Abnormal respiratory motile cilium physiology (HP:0012261)2.61248913
31Absent rod-and cone-mediated responses on ERG (HP:0007688)2.60140132
32Conjunctival telangiectasia (HP:0000524)2.49019342
33Microtia (HP:0008551)2.47858271
34Short middle phalanx of finger (HP:0005819)2.45842482
35Abnormal respiratory motile cilium morphology (HP:0005938)2.42816759
36Abnormal respiratory epithelium morphology (HP:0012253)2.42816759
37Abnormality of alanine metabolism (HP:0010916)2.41571513
38Hyperalaninemia (HP:0003348)2.41571513
39Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.41571513
40Abnormal ciliary motility (HP:0012262)2.39941052
41Nonimmune hydrops fetalis (HP:0001790)2.37091126
42Atrioventricular canal defect (HP:0006695)2.37022563
43Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.36694962
44Abnormality of secondary sexual hair (HP:0009888)2.36239345
45Abnormality of the axillary hair (HP:0100134)2.36239345
46Abnormality of reticulocytes (HP:0004312)2.30710655
47Epistaxis (HP:0000421)2.30707085
48Recurrent fungal infections (HP:0002841)2.29557432
49Deep palmar crease (HP:0006191)2.19683162
50Chronic mucocutaneous candidiasis (HP:0002728)2.18475800
51Recurrent cutaneous fungal infections (HP:0011370)2.18475800
52Rhinitis (HP:0012384)2.14829469
53Abnormality of the vasculature of the conjunctiva (HP:0008054)2.14290391
54Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)2.12404602
55Duodenal stenosis (HP:0100867)2.12344201
56Small intestinal stenosis (HP:0012848)2.12344201
57Eczematoid dermatitis (HP:0000976)2.09972426
58Menstrual irregularities (HP:0000858)2.07010879
59Neurodegeneration (HP:0002180)2.01520504
60Recurrent bacterial skin infections (HP:0005406)2.01379897
61Keratoconjunctivitis (HP:0001096)1.99266144
62Recurrent gram-negative bacterial infections (HP:0005420)1.98297107
63Macroglossia (HP:0000158)1.98163898
64Type I transferrin isoform profile (HP:0003642)1.97437950
65Chronic bronchitis (HP:0004469)1.97183793
66Hyperinsulinemic hypoglycemia (HP:0000825)1.96875927
67Heterotopia (HP:0002282)1.94359209
68Abnormality of the renal collecting system (HP:0004742)1.92833104
69Abnormal sex determination (HP:0012244)1.88555512
70Sex reversal (HP:0012245)1.88555512
71Cutaneous photosensitivity (HP:0000992)1.88117872
72Duplicated collecting system (HP:0000081)1.87376073
73Cupped ear (HP:0000378)1.85644698
74Pulmonary artery stenosis (HP:0004415)1.84670350
75Supernumerary nipples (HP:0002558)1.81477204
76Neutropenia (HP:0001875)1.80011296
77Abnormality of midbrain morphology (HP:0002418)1.79366868
78Molar tooth sign on MRI (HP:0002419)1.79366868
79Abnormal rod and cone electroretinograms (HP:0008323)1.77039969
80Spontaneous hematomas (HP:0007420)1.76896517
81Reduced subcutaneous adipose tissue (HP:0003758)1.76895881
82Esophageal neoplasm (HP:0100751)1.76616417
83Neoplasm of head and neck (HP:0012288)1.76616417
84Optic nerve coloboma (HP:0000588)1.75138046
85Anal atresia (HP:0002023)1.74059687
86Abnormality of the middle phalanges of the hand (HP:0009833)1.71846302
87Abnormality of the acetabulum (HP:0003170)1.71327486
88Chronic hepatic failure (HP:0100626)1.68577933
89Bronchitis (HP:0012387)1.65302018
90Hepatocellular necrosis (HP:0001404)1.64368760
91Thickened nuchal skin fold (HP:0000474)1.64150358
92Abnormal biliary tract physiology (HP:0012439)1.63711426
93Bile duct proliferation (HP:0001408)1.63711426
94Low anterior hairline (HP:0000294)1.63527804
95Gingivitis (HP:0000230)1.63508182
96Abnormality of the duodenum (HP:0002246)1.60176319
97Upper motor neuron abnormality (HP:0002127)1.59536363
98Recurrent skin infections (HP:0001581)1.59089273
99Overlapping toe (HP:0001845)1.58583353
100Hematochezia (HP:0002573)1.57654487

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK26.51892972
2CDK126.47263087
3ERN13.70947096
4FRK2.41497565
5ARAF2.36817609
6NUAK12.31245631
7EIF2AK12.23848140
8CDK82.22121342
9RAF12.07974294
10IRAK12.04154122
11MAP3K12.03351580
12PIM22.00595111
13EPHA31.89976997
14IRAK41.81890529
15WNK11.80119258
16AKT31.75939727
17BRAF1.75761468
18PLK21.65280832
19RIPK41.61216221
20TEC1.55765847
21DMPK1.49494434
22BLK1.39226089
23OXSR11.38207451
24MAP3K21.31978608
25STK41.27050892
26PTK2B1.24149153
27CCNB11.09752157
28BTK1.08337226
29EPHB11.06801940
30SYK1.05599183
31EIF2AK31.01828847
32WNK30.98838108
33FES0.97787938
34BRSK20.97021591
35PRKCI0.96897046
36TRPM70.95570835
37PRKD10.91321995
38CSK0.88938430
39ITK0.85085611
40ERBB20.83863280
41PIK3CG0.83014488
42MAPKAPK50.81758941
43MAPK120.80545977
44TYK20.79168877
45NLK0.78932763
46WNK40.74864212
47PAK30.73455080
48FGFR30.73446417
49PDPK10.72595109
50BMPR1B0.71305584
51MAP2K60.70758250
52TAF10.70537202
53GRK50.69735900
54HCK0.69575345
55JAK20.69341262
56BMPR20.68368191
57TAOK30.67652672
58PDK10.64083252
59STK390.60578953
60YES10.58909220
61PIM10.58111162
62RPS6KA50.58002494
63MST40.56430034
64BRD40.55634240
65ACVR1B0.55260801
66ADRBK20.54655342
67MAP2K30.54503819
68IKBKE0.51093198
69SGK20.51081104
70FGFR40.51030156
71KIT0.51009845
72PRKCE0.50834636
73MAP3K70.49490610
74IRAK20.49018868
75PRKG20.47828290
76EEF2K0.47605157
77WEE10.46814309
78TXK0.46448043
79RPS6KA60.46411093
80MAPK130.45321620
81RPS6KA20.45181044
82AKT10.44538859
83NEK60.40903276
84LYN0.40499008
85PRKAA20.40081563
86EIF2AK20.39874826
87NTRK30.36668376
88RPS6KL10.35584424
89RPS6KC10.35584424
90ADRBK10.34871199
91LRRK20.33953038
92SIK20.33387745
93MAPK30.30943751
94PAK10.30301144
95RPS6KA10.28443327
96JAK30.28326965
97FGR0.27555700
98MAPKAPK20.27199004
99BCR0.25507191
100JAK10.25208760

Predicted pathways (KEGG)

RankGene SetZ-score
1Regulation of autophagy_Homo sapiens_hsa041402.68556401
2RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.54533070
3Leishmaniasis_Homo sapiens_hsa051402.32530049
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.30179944
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.18471187
6African trypanosomiasis_Homo sapiens_hsa051432.16928822
7Linoleic acid metabolism_Homo sapiens_hsa005912.08281319
8Staphylococcus aureus infection_Homo sapiens_hsa051501.90069347
9Glycerophospholipid metabolism_Homo sapiens_hsa005641.86754128
10NOD-like receptor signaling pathway_Homo sapiens_hsa046211.85211062
11p53 signaling pathway_Homo sapiens_hsa041151.73413502
12Salmonella infection_Homo sapiens_hsa051321.72519031
13VEGF signaling pathway_Homo sapiens_hsa043701.65485922
14Osteoclast differentiation_Homo sapiens_hsa043801.65038561
15Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.63063607
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.57641986
17Platelet activation_Homo sapiens_hsa046111.53241209
18Basal transcription factors_Homo sapiens_hsa030221.50731901
19Tuberculosis_Homo sapiens_hsa051521.48092125
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.48091558
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.47357329
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.47157531
23Legionellosis_Homo sapiens_hsa051341.41836623
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.35592445
25Hepatitis B_Homo sapiens_hsa051611.27057368
26Asthma_Homo sapiens_hsa053101.21270003
27B cell receptor signaling pathway_Homo sapiens_hsa046621.19081033
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.19013869
29ABC transporters_Homo sapiens_hsa020101.17049642
30Malaria_Homo sapiens_hsa051441.12554991
31Neurotrophin signaling pathway_Homo sapiens_hsa047221.12151560
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.09262636
33Taste transduction_Homo sapiens_hsa047421.07492200
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07058621
35GnRH signaling pathway_Homo sapiens_hsa049121.05521263
36Ether lipid metabolism_Homo sapiens_hsa005651.05075991
37Influenza A_Homo sapiens_hsa051641.04007960
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.02040515
39Apoptosis_Homo sapiens_hsa042101.01536411
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.98550142
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98411588
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.98221985
43Hematopoietic cell lineage_Homo sapiens_hsa046400.97196385
44Complement and coagulation cascades_Homo sapiens_hsa046100.93230174
45Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93196463
46Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.91475250
47Prolactin signaling pathway_Homo sapiens_hsa049170.91230577
48Measles_Homo sapiens_hsa051620.89860328
49Choline metabolism in cancer_Homo sapiens_hsa052310.89415176
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89115971
51Non-small cell lung cancer_Homo sapiens_hsa052230.88241529
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88015110
53Intestinal immune network for IgA production_Homo sapiens_hsa046720.87069441
54T cell receptor signaling pathway_Homo sapiens_hsa046600.86567074
55mTOR signaling pathway_Homo sapiens_hsa041500.85532970
56Arachidonic acid metabolism_Homo sapiens_hsa005900.84155668
57Long-term depression_Homo sapiens_hsa047300.82108572
58Serotonergic synapse_Homo sapiens_hsa047260.81308595
59TNF signaling pathway_Homo sapiens_hsa046680.81029619
60Primary immunodeficiency_Homo sapiens_hsa053400.79600455
61Chemical carcinogenesis_Homo sapiens_hsa052040.79244982
62Phagosome_Homo sapiens_hsa041450.78622641
63Dorso-ventral axis formation_Homo sapiens_hsa043200.78470745
64Lysine degradation_Homo sapiens_hsa003100.76154244
65Glutamatergic synapse_Homo sapiens_hsa047240.74767823
66ErbB signaling pathway_Homo sapiens_hsa040120.74160789
67Graft-versus-host disease_Homo sapiens_hsa053320.73833394
68Nitrogen metabolism_Homo sapiens_hsa009100.73687250
69HIF-1 signaling pathway_Homo sapiens_hsa040660.72770019
70Chemokine signaling pathway_Homo sapiens_hsa040620.71778585
71Mineral absorption_Homo sapiens_hsa049780.71608114
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.71082296
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67911922
74Toxoplasmosis_Homo sapiens_hsa051450.67720647
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65816446
76Gap junction_Homo sapiens_hsa045400.64157161
77Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63824738
78Caffeine metabolism_Homo sapiens_hsa002320.60678597
79Acute myeloid leukemia_Homo sapiens_hsa052210.60625420
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59641574
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.59621289
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58776984
83Autoimmune thyroid disease_Homo sapiens_hsa053200.56378643
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56001096
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55349997
86Allograft rejection_Homo sapiens_hsa053300.55255363
87Pancreatic cancer_Homo sapiens_hsa052120.52963921
88Non-homologous end-joining_Homo sapiens_hsa034500.51186027
89Ovarian steroidogenesis_Homo sapiens_hsa049130.50933267
90Glycerolipid metabolism_Homo sapiens_hsa005610.50048296
91FoxO signaling pathway_Homo sapiens_hsa040680.49561789
92Pertussis_Homo sapiens_hsa051330.48869525
93Estrogen signaling pathway_Homo sapiens_hsa049150.47327807
94Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46538134
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.46403376
96PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44622863
97Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41403474
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.41168032
99One carbon pool by folate_Homo sapiens_hsa006700.40546892
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40466644

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