ZNF416

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)5.91696129
2RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)5.91696129
3mitochondrial RNA metabolic process (GO:0000959)5.45070159
4negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.23828161
5regulation of retinoic acid receptor signaling pathway (GO:0048385)4.62584035
6IMP biosynthetic process (GO:0006188)4.60885853
7folic acid-containing compound biosynthetic process (GO:0009396)4.54650038
8protein localization to chromosome, centromeric region (GO:0071459)4.34913361
9IMP metabolic process (GO:0046040)4.28323679
10L-serine metabolic process (GO:0006563)4.26937080
11somatic hypermutation of immunoglobulin genes (GO:0016446)4.24540513
12somatic diversification of immune receptors via somatic mutation (GO:0002566)4.24540513
13CENP-A containing nucleosome assembly (GO:0034080)4.20243462
14chromatin remodeling at centromere (GO:0031055)4.03786202
15homocysteine metabolic process (GO:0050667)3.93594828
16DNA ligation (GO:0006266)3.88055156
17pseudouridine synthesis (GO:0001522)3.82258757
18transcription from mitochondrial promoter (GO:0006390)3.77368697
19mitotic chromosome condensation (GO:0007076)3.68441509
20adenosine metabolic process (GO:0046085)3.61773235
21DNA replication-dependent nucleosome organization (GO:0034723)3.59818157
22DNA replication-dependent nucleosome assembly (GO:0006335)3.59818157
23regulation of DNA methylation (GO:0044030)3.56352337
24folic acid transport (GO:0015884)3.54620135
25activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.49376937
26sulfur amino acid catabolic process (GO:0000098)3.47692873
27DNA replication-independent nucleosome assembly (GO:0006336)3.44203644
28DNA replication-independent nucleosome organization (GO:0034724)3.44203644
29rRNA modification (GO:0000154)3.38778687
30regulation of helicase activity (GO:0051095)3.38493843
31peptidyl-arginine omega-N-methylation (GO:0035247)3.37176382
32rRNA methylation (GO:0031167)3.35847474
33protein localization to kinetochore (GO:0034501)3.35443999
34positive regulation of mitochondrial fission (GO:0090141)3.35417747
35histone exchange (GO:0043486)3.31828631
36mitotic metaphase plate congression (GO:0007080)3.31490717
37base-excision repair (GO:0006284)3.30879997
38ribosome biogenesis (GO:0042254)3.27320314
39regulation of spindle checkpoint (GO:0090231)3.25566679
40microtubule nucleation (GO:0007020)3.21759854
41positive regulation of endothelial cell differentiation (GO:0045603)3.21749114
42nuclear pore complex assembly (GO:0051292)3.21178893
43cysteine metabolic process (GO:0006534)3.18904079
44DNA strand elongation involved in DNA replication (GO:0006271)3.14062948
45polyamine biosynthetic process (GO:0006596)3.12194611
46DNA strand elongation (GO:0022616)3.10983309
47purine nucleotide salvage (GO:0032261)3.10818604
48histone arginine methylation (GO:0034969)3.09658112
49tRNA methylation (GO:0030488)3.05162623
50cellular protein complex localization (GO:0034629)3.03287114
51peptidyl-arginine N-methylation (GO:0035246)3.03032464
52peptidyl-arginine methylation (GO:0018216)3.03032464
53pore complex assembly (GO:0046931)3.02975969
54pteridine-containing compound biosynthetic process (GO:0042559)2.99019772
55nuclear pore organization (GO:0006999)2.97404391
56chromosome condensation (GO:0030261)2.95574463
57regulation of mitotic spindle checkpoint (GO:1903504)2.94763674
58regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.94763674
59tRNA modification (GO:0006400)2.91341038
60RNA methylation (GO:0001510)2.91254587
61protein localization to chromosome (GO:0034502)2.91090657
62establishment of integrated proviral latency (GO:0075713)2.90881017
63regulation of plasminogen activation (GO:0010755)2.88150011
64negative regulation of chromosome segregation (GO:0051985)2.88051089
65metaphase plate congression (GO:0051310)2.85621397
66negative regulation of mitotic sister chromatid separation (GO:2000816)2.84540015
67negative regulation of sister chromatid segregation (GO:0033046)2.84540015
68negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.84540015
69negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.84540015
70negative regulation of mitotic sister chromatid segregation (GO:0033048)2.84540015
71snRNA metabolic process (GO:0016073)2.83862949
72pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.83407506
73spindle checkpoint (GO:0031577)2.80284972
74meiotic cell cycle (GO:0051321)2.80203332
75DNA deamination (GO:0045006)2.78512828
76histone H4-K12 acetylation (GO:0043983)2.76964948
77regulation of meiosis I (GO:0060631)2.75577500
78phosphatidylglycerol biosynthetic process (GO:0006655)2.73557110
79mitotic spindle checkpoint (GO:0071174)2.72717112
80regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.72561259
81telomere maintenance via semi-conservative replication (GO:0032201)2.70823941
82mitotic nuclear envelope disassembly (GO:0007077)2.70480846
83regulation of histone H3-K9 methylation (GO:0051570)2.69424243
84ATP-dependent chromatin remodeling (GO:0043044)2.68529359
85establishment of viral latency (GO:0019043)2.68017792
86histone H4-K5 acetylation (GO:0043981)2.67322972
87histone H4-K8 acetylation (GO:0043982)2.67322972
88tRNA processing (GO:0008033)2.65682319
89alternative mRNA splicing, via spliceosome (GO:0000380)2.65528495
90base-excision repair, AP site formation (GO:0006285)2.63403825
91rRNA transcription (GO:0009303)2.63175759
92chromatin assembly or disassembly (GO:0006333)2.62630959
93protein deneddylation (GO:0000338)2.61969841
94serine family amino acid biosynthetic process (GO:0009070)2.61939312
95attachment of spindle microtubules to kinetochore (GO:0008608)2.60352976
96mitotic spindle assembly checkpoint (GO:0007094)2.60141734
97RNA modification (GO:0009451)2.59276827
98regulation of chromatin binding (GO:0035561)2.59176420
99regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.58874350
100regulation of mitotic metaphase/anaphase transition (GO:0030071)2.58874350

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.08322453
2E2F7_22180533_ChIP-Seq_HELA_Human5.39069398
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.35783013
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.70473962
5* NOTCH1_21737748_ChIP-Seq_TLL_Human3.60760105
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.40780576
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.26241285
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.19475750
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.14394389
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.07452027
11MYC_18555785_ChIP-Seq_MESCs_Mouse3.06343875
12E2F4_17652178_ChIP-ChIP_JURKAT_Human3.03750474
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.93592488
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.87685493
15* ETS1_20019798_ChIP-Seq_JURKAT_Human2.62255725
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.60795812
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.46963570
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.43632758
19VDR_23849224_ChIP-Seq_CD4+_Human2.42795931
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.42187084
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.34466291
22* FOXP3_21729870_ChIP-Seq_TREG_Human2.32380358
23GABP_19822575_ChIP-Seq_HepG2_Human2.30065258
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.28053238
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.27542354
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.24924814
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.22417610
28DCP1A_22483619_ChIP-Seq_HELA_Human2.19356422
29MYC_19079543_ChIP-ChIP_MESCs_Mouse2.12616839
30MYCN_18555785_ChIP-Seq_MESCs_Mouse2.08810584
31AR_21909140_ChIP-Seq_LNCAP_Human2.08432961
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.07112195
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.99611015
34ELK1_19687146_ChIP-ChIP_HELA_Human1.96325133
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.95491754
36ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.93842793
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.92038090
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.84026931
39TP63_19390658_ChIP-ChIP_HaCaT_Human1.82442809
40XRN2_22483619_ChIP-Seq_HELA_Human1.82103326
41PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.81655165
42KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.79732832
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76568036
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.75516224
45CIITA_25753668_ChIP-Seq_RAJI_Human1.73620893
46CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.73441060
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.69992165
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.69528760
49EZH2_22144423_ChIP-Seq_EOC_Human1.66960656
50IRF1_19129219_ChIP-ChIP_H3396_Human1.65772874
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.65106007
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.64298499
53TTF2_22483619_ChIP-Seq_HELA_Human1.62005888
54PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.61791618
55E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.58927944
56NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.56131299
57CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.52358626
58CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.52016209
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.50367714
60TFEB_21752829_ChIP-Seq_HELA_Human1.48720257
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.46840783
62SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.34263795
63KDM5A_27292631_Chip-Seq_BREAST_Human1.31971328
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.30988672
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.30101370
66CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.28668946
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27076336
68BP1_19119308_ChIP-ChIP_Hs578T_Human1.25864606
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21603276
70MYC_18940864_ChIP-ChIP_HL60_Human1.21570703
71CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.18619597
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18262005
73ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17894684
74KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.15725733
75KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.15725733
76KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.15725733
77SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14912515
78BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13368450
79* SOX2_16153702_ChIP-ChIP_HESCs_Human1.11760359
80POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10069299
81CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08972643
82* NANOG_16153702_ChIP-ChIP_HESCs_Human1.07383234
83NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07360293
84CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05179990
85SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.03505821
86KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02424206
87SALL1_21062744_ChIP-ChIP_HESCs_Human0.99604489
88TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.94389285
89SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94020584
90ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91927058
91TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91569683
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.87095583
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.86108661
94ZNF263_19887448_ChIP-Seq_K562_Human0.85284114
95NANOG_21062744_ChIP-ChIP_HESCs_Human0.84258952
96EWS_26573619_Chip-Seq_HEK293_Human0.80854362
97GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.80664898
98FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.80632652
99CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.79878799
100PKCTHETA_26484144_Chip-Seq_BREAST_Human0.77645063

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect4.33951809
2MP0008058_abnormal_DNA_repair3.68025863
3MP0003111_abnormal_nucleus_morphology3.61279409
4MP0010094_abnormal_chromosome_stability3.38229654
5MP0008789_abnormal_olfactory_epithelium3.14940103
6MP0003693_abnormal_embryo_hatching3.12242641
7MP0003077_abnormal_cell_cycle2.97217485
8MP0005499_abnormal_olfactory_system2.92662311
9MP0005394_taste/olfaction_phenotype2.92662311
10MP0008995_early_reproductive_senescence2.63735622
11MP0010307_abnormal_tumor_latency2.54361887
12MP0004957_abnormal_blastocyst_morpholog2.46032548
13MP0006292_abnormal_olfactory_placode2.35874243
14MP0008932_abnormal_embryonic_tissue2.24454039
15MP0008007_abnormal_cellular_replicative2.07722000
16MP0002138_abnormal_hepatobiliary_system2.00728618
17MP0003890_abnormal_embryonic-extraembry1.92186991
18MP0001730_embryonic_growth_arrest1.86552284
19MP0003221_abnormal_cardiomyocyte_apopto1.82334047
20MP0000516_abnormal_urinary_system1.81341172
21MP0005367_renal/urinary_system_phenotyp1.81341172
22MP0002102_abnormal_ear_morphology1.73669037
23MP0008260_abnormal_autophagy1.71987059
24MP0003786_premature_aging1.71029542
25MP0001984_abnormal_olfaction1.64337951
26MP0001293_anophthalmia1.63858631
27MP0002396_abnormal_hematopoietic_system1.62927768
28MP0010030_abnormal_orbit_morphology1.56234930
29MP0005395_other_phenotype1.55564762
30MP0003941_abnormal_skin_development1.55346296
31MP0002233_abnormal_nose_morphology1.53829393
32MP0010234_abnormal_vibrissa_follicle1.49174119
33MP0001672_abnormal_embryogenesis/_devel1.47755360
34MP0005380_embryogenesis_phenotype1.47755360
35MP0002234_abnormal_pharynx_morphology1.47139321
36MP0000647_abnormal_sebaceous_gland1.43750097
37MP0001929_abnormal_gametogenesis1.42777675
38MP0001529_abnormal_vocalization1.41782837
39MP0003567_abnormal_fetal_cardiomyocyte1.41264246
40MP0002210_abnormal_sex_determination1.36390321
41MP0010352_gastrointestinal_tract_polyps1.34284411
42MP0000350_abnormal_cell_proliferation1.34176735
43MP0000653_abnormal_sex_gland1.30003231
44MP0008057_abnormal_DNA_replication1.27710140
45MP0004147_increased_porphyrin_level1.26597061
46MP0001919_abnormal_reproductive_system1.23605837
47MP0002938_white_spotting1.21417545
48MP0002160_abnormal_reproductive_system1.17515966
49MP0003984_embryonic_growth_retardation1.17489714
50MP0003699_abnormal_female_reproductive1.17141684
51MP0006035_abnormal_mitochondrial_morpho1.16171462
52MP0001145_abnormal_male_reproductive1.14774846
53MP0001119_abnormal_female_reproductive1.10333162
54MP0002088_abnormal_embryonic_growth/wei1.09677379
55MP0000750_abnormal_muscle_regeneration1.06495406
56MP0003186_abnormal_redox_activity1.06246029
57MP0000313_abnormal_cell_death1.05410488
58MP0003183_abnormal_peptide_metabolism1.04775455
59MP0005389_reproductive_system_phenotype1.04752822
60MP0001286_abnormal_eye_development1.03614110
61MP0001661_extended_life_span1.02517736
62MP0002085_abnormal_embryonic_tissue1.01941805
63MP0000049_abnormal_middle_ear1.01476326
64MP0001340_abnormal_eyelid_morphology1.00086552
65MP0004133_heterotaxia0.96935245
66MP0002697_abnormal_eye_size0.95185380
67MP0002163_abnormal_gland_morphology0.94984277
68MP0002080_prenatal_lethality0.94904556
69MP0001697_abnormal_embryo_size0.93564918
70MP0002736_abnormal_nociception_after0.92682650
71MP0000762_abnormal_tongue_morphology0.91732583
72MP0000566_synostosis0.91071249
73MP0004197_abnormal_fetal_growth/weight/0.90794810
74MP0002111_abnormal_tail_morphology0.90731414
75MP0002084_abnormal_developmental_patter0.90486140
76MP0003755_abnormal_palate_morphology0.89326076
77MP0002269_muscular_atrophy0.86882667
78MP0002161_abnormal_fertility/fecundity0.85272933
79MP0005248_abnormal_Harderian_gland0.83998479
80MP0002177_abnormal_outer_ear0.83846863
81MP0002019_abnormal_tumor_incidence0.82881072
82MP0005220_abnormal_exocrine_pancreas0.80657570
83MP0001324_abnormal_eye_pigmentation0.76273920
84MP0003937_abnormal_limbs/digits/tail_de0.75596662
85MP0002751_abnormal_autonomic_nervous0.75370724
86MP0004233_abnormal_muscle_weight0.75021108
87MP0005646_abnormal_pituitary_gland0.74688145
88MP0000579_abnormal_nail_morphology0.74172355
89MP0003806_abnormal_nucleotide_metabolis0.73014100
90MP0009672_abnormal_birth_weight0.72704513
91MP0000733_abnormal_muscle_development0.72291819
92MP0005647_abnormal_sex_gland0.71254864
93MP0008877_abnormal_DNA_methylation0.70455780
94MP0002009_preneoplasia0.69722133
95MP0002653_abnormal_ependyma_morphology0.69475003
96MP0006276_abnormal_autonomic_nervous0.67747277
97MP0009703_decreased_birth_body0.67479198
98MP0006072_abnormal_retinal_apoptosis0.66870405
99MP0002086_abnormal_extraembryonic_tissu0.66478970
100MP0002092_abnormal_eye_morphology0.66206723

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of alanine metabolism (HP:0010916)5.06825779
2Hyperalaninemia (HP:0003348)5.06825779
3Abnormality of pyruvate family amino acid metabolism (HP:0010915)5.06825779
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.80438164
5Chromsome breakage (HP:0040012)3.86358760
6Hyperglycinemia (HP:0002154)3.67709538
7Microvesicular hepatic steatosis (HP:0001414)3.57876159
8Abnormality of the phalanges of the hallux (HP:0010057)3.24875396
9Colon cancer (HP:0003003)3.16319545
10Carpal bone hypoplasia (HP:0001498)3.15226113
11Supernumerary spleens (HP:0009799)2.94049717
12Premature ovarian failure (HP:0008209)2.91846992
13Abnormality of serum amino acid levels (HP:0003112)2.88256229
14Birth length less than 3rd percentile (HP:0003561)2.86878475
15Constricted visual fields (HP:0001133)2.85027257
16Impulsivity (HP:0100710)2.82203438
17Abnormality of the fetal cardiovascular system (HP:0010948)2.76074129
18Abnormal umbilical cord blood vessels (HP:0011403)2.76074129
19Single umbilical artery (HP:0001195)2.76074129
20Abnormal lung lobation (HP:0002101)2.74413526
21Shoulder girdle muscle weakness (HP:0003547)2.72986116
22Nephrogenic diabetes insipidus (HP:0009806)2.72450699
23Meckel diverticulum (HP:0002245)2.70887713
24Cortical dysplasia (HP:0002539)2.66728651
25Abnormality of the ileum (HP:0001549)2.63227683
26Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.57378681
27Nephroblastoma (Wilms tumor) (HP:0002667)2.55052088
28Median cleft lip (HP:0000161)2.45582108
29Decreased electroretinogram (ERG) amplitude (HP:0000654)2.40705444
30Poor speech (HP:0002465)2.40516847
31Medulloblastoma (HP:0002885)2.39167100
32Methylmalonic acidemia (HP:0002912)2.36879027
33Pelvic girdle muscle weakness (HP:0003749)2.36408356
34Congenital primary aphakia (HP:0007707)2.36380540
35Cone-rod dystrophy (HP:0000548)2.34931305
36Homocystinuria (HP:0002156)2.30513476
37Abnormality of homocysteine metabolism (HP:0010919)2.30513476
38Embryonal renal neoplasm (HP:0011794)2.30088326
39Abnormality of the preputium (HP:0100587)2.27661551
40Aplasia/Hypoplasia of the uvula (HP:0010293)2.26253490
41Abnormality of the septum pellucidum (HP:0007375)2.26071079
42Gait imbalance (HP:0002141)2.24552253
43Abnormality of the musculature of the pelvis (HP:0001469)2.21012703
44Abnormality of the hip-girdle musculature (HP:0001445)2.21012703
45Absent septum pellucidum (HP:0001331)2.20821038
46Abnormality of the labia minora (HP:0012880)2.20633848
47Increased serum pyruvate (HP:0003542)2.19096039
48Rhabdomyosarcoma (HP:0002859)2.11062677
49Esophageal varix (HP:0002040)2.10334011
50Abnormality of abdominal situs (HP:0011620)2.09467843
51Abdominal situs inversus (HP:0003363)2.09467843
52Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.07782339
53Type 2 muscle fiber atrophy (HP:0003554)2.04982146
54Arteriovenous malformation (HP:0100026)2.04669140
55Horseshoe kidney (HP:0000085)2.03345504
56Short tibia (HP:0005736)2.02895476
57Ependymoma (HP:0002888)2.01389872
58Abnormality of sulfur amino acid metabolism (HP:0004339)2.00854461
59Abnormality of glycolysis (HP:0004366)1.99383625
60Complete atrioventricular canal defect (HP:0001674)1.97839814
61Muscle fiber atrophy (HP:0100295)1.97691030
62Abnormality of the umbilical cord (HP:0010881)1.97137135
63Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.95631853
64Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.94101453
65Abnormal protein N-linked glycosylation (HP:0012347)1.94101453
66Abnormal protein glycosylation (HP:0012346)1.94101453
67Abnormal glycosylation (HP:0012345)1.94101453
68Hypergonadotropic hypogonadism (HP:0000815)1.93685171
69Multiple enchondromatosis (HP:0005701)1.93628706
70Sensory axonal neuropathy (HP:0003390)1.93128670
71Abnormality of chromosome stability (HP:0003220)1.92498978
72Duodenal stenosis (HP:0100867)1.92290486
73Small intestinal stenosis (HP:0012848)1.92290486
74Degeneration of anterior horn cells (HP:0002398)1.91773977
75Abnormality of the anterior horn cell (HP:0006802)1.91773977
76Broad foot (HP:0001769)1.90834740
77Progressive muscle weakness (HP:0003323)1.89871163
78Cortical visual impairment (HP:0100704)1.89288122
79Duplicated collecting system (HP:0000081)1.89155826
80Duplication of thumb phalanx (HP:0009942)1.88518929
81Patchy hypopigmentation of hair (HP:0011365)1.85789356
82Absent radius (HP:0003974)1.85435317
83Increased serum lactate (HP:0002151)1.85015753
84Progressive inability to walk (HP:0002505)1.84248486
85White forelock (HP:0002211)1.84143110
86Abnormality of glycine metabolism (HP:0010895)1.83256637
87Abnormality of serine family amino acid metabolism (HP:0010894)1.83256637
88Atrophy/Degeneration involving motor neurons (HP:0007373)1.82022257
89Bone marrow hypocellularity (HP:0005528)1.80979567
90Aplasia involving forearm bones (HP:0009822)1.79308917
91Absent forearm bone (HP:0003953)1.79308917
92Capillary hemangiomas (HP:0005306)1.77867502
93Abnormality of the carotid arteries (HP:0005344)1.75934449
94Aplastic anemia (HP:0001915)1.75445922
95Agnosia (HP:0010524)1.75131627
96Astrocytoma (HP:0009592)1.74880371
97Abnormality of the astrocytes (HP:0100707)1.74880371
98High anterior hairline (HP:0009890)1.74685273
99Medial flaring of the eyebrow (HP:0010747)1.74430066
100Abnormality of the renal collecting system (HP:0004742)1.73595307

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM284.53650887
2SRPK14.48847967
3BUB13.40779712
4BCKDK3.08837939
5BCR2.34840573
6MAP4K22.29183044
7TTK2.26529234
8CDC72.22922645
9LMTK22.14384326
10CDK92.08999365
11BRD41.94272365
12CDK191.89749691
13ZAK1.88031294
14CSNK1A1L1.78095817
15CSNK1G11.76089423
16CSNK1G31.70880868
17CDK71.69228076
18CDK81.66352339
19EIF2AK31.58524926
20NUAK11.57572901
21DYRK31.56039274
22PLK11.53328395
23AURKA1.52312409
24BRSK21.48831645
25ARAF1.44047955
26PIM21.37952944
27MAP2K71.37369821
28FGR1.34688749
29PBK1.34047003
30NTRK21.31910515
31BMPR1B1.24350184
32PLK41.24334496
33MAP3K91.23801844
34FLT31.22308944
35NEK61.18864927
36TSSK61.18105944
37ATR1.17127697
38PLK31.16596330
39MAP3K41.12459484
40CSNK1G21.12446066
41MAP3K31.12307878
42ERBB31.07713924
43CDK121.07176147
44TESK21.01580072
45BRSK11.01440386
46JAK30.99076638
47DYRK1B0.98855752
48VRK20.97862268
49RAF10.96182090
50CHEK20.94122415
51TXK0.93011940
52PAK40.92531670
53AURKB0.91417326
54CHEK10.89774159
55WEE10.89278968
56STK160.88629749
57PIM10.87726456
58MKNK10.83893776
59PRKCI0.83576106
60VRK10.83405738
61TAOK30.76312271
62ADRBK20.76063861
63BRAF0.75244947
64EIF2AK20.74650524
65MAP3K130.73357419
66TNIK0.73040770
67MAP2K30.71374664
68ATM0.69328810
69WNK30.69108485
70ACVR1B0.66430963
71CDK20.66181191
72SCYL20.64625468
73MKNK20.64602883
74KSR20.64463024
75STK240.57703490
76NEK90.56403534
77DYRK20.55161469
78CDK60.54896855
79RPS6KA40.52870806
80ERBB40.50570586
81MOS0.50230386
82TGFBR10.47911718
83STK100.47462060
84KDR0.46177394
85CSNK1A10.45274597
86PAK10.43568225
87MAP3K80.42458196
88PASK0.40674315
89EGFR0.39706808
90PAK60.37949736
91CDK140.35108934
92CDK10.33938313
93RPS6KB20.33833705
94AKT20.33184906
95KSR10.32970449
96IKBKB0.32341888
97MATK0.32224831
98MELK0.31999167
99MAPK130.31646307
100RPS6KA10.31357596

Predicted pathways (KEGG)

RankGene SetZ-score
1Base excision repair_Homo sapiens_hsa034103.58394530
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.29610391
3DNA replication_Homo sapiens_hsa030303.12370902
4Mismatch repair_Homo sapiens_hsa034303.09248784
5Non-homologous end-joining_Homo sapiens_hsa034502.74825066
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.70443911
7RNA transport_Homo sapiens_hsa030132.68285290
8Cell cycle_Homo sapiens_hsa041102.67253983
9Basal transcription factors_Homo sapiens_hsa030222.44260189
10Spliceosome_Homo sapiens_hsa030402.35169677
11RNA polymerase_Homo sapiens_hsa030202.31004270
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.30058760
13Cysteine and methionine metabolism_Homo sapiens_hsa002702.25033235
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.22812770
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.08339263
16Fanconi anemia pathway_Homo sapiens_hsa034602.02815868
17One carbon pool by folate_Homo sapiens_hsa006701.99888424
18Homologous recombination_Homo sapiens_hsa034401.94232165
19RNA degradation_Homo sapiens_hsa030181.94019281
20mRNA surveillance pathway_Homo sapiens_hsa030151.90435140
21p53 signaling pathway_Homo sapiens_hsa041151.83604595
22Proteasome_Homo sapiens_hsa030501.81564955
23Biosynthesis of amino acids_Homo sapiens_hsa012301.80732383
24Steroid biosynthesis_Homo sapiens_hsa001001.76648313
25Selenocompound metabolism_Homo sapiens_hsa004501.71965743
26Collecting duct acid secretion_Homo sapiens_hsa049661.69829085
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.62920857
28Nucleotide excision repair_Homo sapiens_hsa034201.59841335
29Sulfur relay system_Homo sapiens_hsa041221.57520579
30Regulation of autophagy_Homo sapiens_hsa041401.53310694
31Fatty acid elongation_Homo sapiens_hsa000621.44928212
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.44184337
33Pyrimidine metabolism_Homo sapiens_hsa002401.41948854
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.31898129
35Oocyte meiosis_Homo sapiens_hsa041141.25103055
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16972551
37Carbon metabolism_Homo sapiens_hsa012001.16918887
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.16528463
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.12367203
40Vibrio cholerae infection_Homo sapiens_hsa051101.10359452
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.04714582
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.03460444
43Folate biosynthesis_Homo sapiens_hsa007901.03457937
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.00062942
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99153640
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99080001
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.97421910
48Purine metabolism_Homo sapiens_hsa002300.93464067
49Thyroid cancer_Homo sapiens_hsa052160.91969422
50Propanoate metabolism_Homo sapiens_hsa006400.90084267
51Sulfur metabolism_Homo sapiens_hsa009200.77028698
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74100400
53Viral carcinogenesis_Homo sapiens_hsa052030.73623204
54Galactose metabolism_Homo sapiens_hsa000520.71772080
55Epstein-Barr virus infection_Homo sapiens_hsa051690.70771676
56Alcoholism_Homo sapiens_hsa050340.69152452
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66365304
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66157676
59Peroxisome_Homo sapiens_hsa041460.64863111
60Primary immunodeficiency_Homo sapiens_hsa053400.61516036
61TGF-beta signaling pathway_Homo sapiens_hsa043500.61103260
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55707562
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54310535
64Nicotine addiction_Homo sapiens_hsa050330.53240308
65Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52450479
66Glutathione metabolism_Homo sapiens_hsa004800.50209598
67Herpes simplex infection_Homo sapiens_hsa051680.47985926
68MicroRNAs in cancer_Homo sapiens_hsa052060.47666950
69Pyruvate metabolism_Homo sapiens_hsa006200.43106809
70Hippo signaling pathway_Homo sapiens_hsa043900.42785781
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42618774
72GABAergic synapse_Homo sapiens_hsa047270.42091404
73Arginine biosynthesis_Homo sapiens_hsa002200.41711297
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.41052294
75Metabolic pathways_Homo sapiens_hsa011000.39084009
76Apoptosis_Homo sapiens_hsa042100.36165730
77Protein export_Homo sapiens_hsa030600.35305291
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34907423
79Shigellosis_Homo sapiens_hsa051310.33968468
80Arginine and proline metabolism_Homo sapiens_hsa003300.33080560
81Systemic lupus erythematosus_Homo sapiens_hsa053220.32519676
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31671077
83Pentose phosphate pathway_Homo sapiens_hsa000300.30789384
84Colorectal cancer_Homo sapiens_hsa052100.29399835
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28978141
86Phenylalanine metabolism_Homo sapiens_hsa003600.28281366
87Huntingtons disease_Homo sapiens_hsa050160.27646588
88Legionellosis_Homo sapiens_hsa051340.26935047
89Hepatitis B_Homo sapiens_hsa051610.26918647
90Butanoate metabolism_Homo sapiens_hsa006500.26886276
91Fatty acid biosynthesis_Homo sapiens_hsa000610.26759708
92Fatty acid metabolism_Homo sapiens_hsa012120.24911383
93Circadian rhythm_Homo sapiens_hsa047100.20467935
94Vitamin B6 metabolism_Homo sapiens_hsa007500.20339055
95Synaptic vesicle cycle_Homo sapiens_hsa047210.19618026
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.19274318
97Taste transduction_Homo sapiens_hsa047420.16073784
98HTLV-I infection_Homo sapiens_hsa051660.15550403
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.15388767
100Rheumatoid arthritis_Homo sapiens_hsa053230.14522665

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