ZNF417

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1interferon-gamma production (GO:0032609)5.95137784
2negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)5.65820952
3positive regulation of T cell cytokine production (GO:0002726)5.17287176
4negative regulation of T cell mediated immunity (GO:0002710)5.09876838
5neural tube formation (GO:0001841)4.34065042
6negative regulation of translation, ncRNA-mediated (GO:0040033)4.32993187
7regulation of translation, ncRNA-mediated (GO:0045974)4.32993187
8negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.32993187
9positive regulation of T cell chemotaxis (GO:0010820)4.05838023
10regulation of T cell chemotaxis (GO:0010819)4.05838023
11positive regulation of alpha-beta T cell proliferation (GO:0046641)4.00554453
12fucose catabolic process (GO:0019317)3.97016863
13L-fucose metabolic process (GO:0042354)3.97016863
14L-fucose catabolic process (GO:0042355)3.97016863
15behavioral response to nicotine (GO:0035095)3.78787110
16negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.73626777
17protein K11-linked deubiquitination (GO:0035871)3.67895302
18positive regulation of T-helper 1 type immune response (GO:0002827)3.48154537
19negative regulation of adaptive immune response (GO:0002820)3.45488144
20negative regulation of alpha-beta T cell activation (GO:0046636)3.34756378
21DNA deamination (GO:0045006)3.33300806
22regulation of T cell cytokine production (GO:0002724)3.32302429
23monoubiquitinated protein deubiquitination (GO:0035520)3.31826357
24regulation of T-helper 1 type immune response (GO:0002825)3.28811464
25kidney morphogenesis (GO:0060993)3.27110418
26cytoplasmic mRNA processing body assembly (GO:0033962)3.25912545
27activated T cell proliferation (GO:0050798)3.19710298
28regulation of alpha-beta T cell proliferation (GO:0046640)3.17936681
29epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.06230848
30negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.98125647
31negative regulation of T-helper cell differentiation (GO:0045623)2.98125647
32establishment of protein localization to Golgi (GO:0072600)2.95162668
33positive regulation of gamma-delta T cell activation (GO:0046645)2.90658243
34regulation of telomere maintenance (GO:0032204)2.89651452
35pyrimidine nucleobase catabolic process (GO:0006208)2.86731858
36axoneme assembly (GO:0035082)2.86644517
37interkinetic nuclear migration (GO:0022027)2.86349498
38detection of light stimulus involved in sensory perception (GO:0050962)2.82672155
39detection of light stimulus involved in visual perception (GO:0050908)2.82672155
40cellular response to interleukin-15 (GO:0071350)2.79936512
41tachykinin receptor signaling pathway (GO:0007217)2.79925246
42response to pheromone (GO:0019236)2.77456853
43DNA double-strand break processing (GO:0000729)2.74719151
44regulation of cilium movement (GO:0003352)2.73891644
45regulation of memory T cell differentiation (GO:0043380)2.73500642
46rRNA catabolic process (GO:0016075)2.73413832
47histone H3-K9 methylation (GO:0051567)2.73150924
48protein polyglutamylation (GO:0018095)2.73078007
49microtubule anchoring (GO:0034453)2.69983814
50regulation of hippo signaling (GO:0035330)2.69333610
51detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.67807530
52negative regulation of lymphocyte mediated immunity (GO:0002707)2.67794278
53positive regulation of T cell mediated cytotoxicity (GO:0001916)2.67573306
54regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.67375238
55positive regulation of type 2 immune response (GO:0002830)2.63445733
56regulation of T cell mediated cytotoxicity (GO:0001914)2.63384103
57regulation of gamma-delta T cell differentiation (GO:0045586)2.60128053
58response to interleukin-15 (GO:0070672)2.57967786
59RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.57723259
60protein localization to cilium (GO:0061512)2.57446948
61protein targeting to Golgi (GO:0000042)2.56894381
62cornea development in camera-type eye (GO:0061303)2.55117327
63positive regulation of defense response to virus by host (GO:0002230)2.51952928
64phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.50715685
65photoreceptor cell maintenance (GO:0045494)2.49971341
66histone mRNA catabolic process (GO:0071044)2.49389145
67DNA methylation involved in gamete generation (GO:0043046)2.49366622
68histone H3-K4 trimethylation (GO:0080182)2.49349579
69epithelial cilium movement (GO:0003351)2.48108913
70preassembly of GPI anchor in ER membrane (GO:0016254)2.47683118
71indolalkylamine metabolic process (GO:0006586)2.47573449
72negative regulation of alpha-beta T cell differentiation (GO:0046639)2.46632241
73adaptation of signaling pathway (GO:0023058)2.46063378
74protein localization to Golgi apparatus (GO:0034067)2.45670065
75mast cell degranulation (GO:0043303)2.44988041
76mast cell activation involved in immune response (GO:0002279)2.44988041
77ncRNA catabolic process (GO:0034661)2.44760154
78negative regulation of DNA-dependent DNA replication (GO:2000104)2.44650196
79atrial cardiac muscle cell action potential (GO:0086014)2.43729675
80regulation of nuclear cell cycle DNA replication (GO:0033262)2.42544263
81retinal cone cell development (GO:0046549)2.42326534
82indole-containing compound catabolic process (GO:0042436)2.42306239
83indolalkylamine catabolic process (GO:0046218)2.42306239
84tryptophan catabolic process (GO:0006569)2.42306239
85positive regulation of granulocyte differentiation (GO:0030854)2.41967567
86replication fork processing (GO:0031297)2.41887307
87cilium morphogenesis (GO:0060271)2.39634888
88piRNA metabolic process (GO:0034587)2.38360494
89regulation of hexokinase activity (GO:1903299)2.37814604
90regulation of glucokinase activity (GO:0033131)2.37814604
91regulation of gamma-delta T cell activation (GO:0046643)2.37717511
92inositol phosphate catabolic process (GO:0071545)2.36821871
93reciprocal DNA recombination (GO:0035825)2.35160705
94reciprocal meiotic recombination (GO:0007131)2.35160705
95embryonic epithelial tube formation (GO:0001838)2.34822165
96protein K48-linked deubiquitination (GO:0071108)2.34563209
97early endosome to late endosome transport (GO:0045022)2.34215927
98head development (GO:0060322)2.33620656
99negative regulation of execution phase of apoptosis (GO:1900118)2.33277990
100phosphorelay signal transduction system (GO:0000160)2.32876069

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ZNF274_21170338_ChIP-Seq_K562_Hela3.98476471
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.21526325
3VDR_22108803_ChIP-Seq_LS180_Human3.20913824
4GBX2_23144817_ChIP-Seq_PC3_Human2.75211841
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.64241556
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.62251403
7IGF1R_20145208_ChIP-Seq_DFB_Human2.55425296
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.48376642
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.37773656
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.24827458
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.22881107
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.19019435
13TAF15_26573619_Chip-Seq_HEK293_Human2.15399782
14EWS_26573619_Chip-Seq_HEK293_Human2.10759416
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.09298217
16ER_23166858_ChIP-Seq_MCF-7_Human2.01460102
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.99147157
18IRF8_22096565_ChIP-ChIP_GC-B_Human1.98696085
19SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.98296043
20FUS_26573619_Chip-Seq_HEK293_Human1.97874202
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95732110
22P300_19829295_ChIP-Seq_ESCs_Human1.93795809
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.91806067
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90731459
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.88608656
26EZH2_22144423_ChIP-Seq_EOC_Human1.82654174
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76107241
28IRF1_19129219_ChIP-ChIP_H3396_Human1.74738796
29STAT3_23295773_ChIP-Seq_U87_Human1.73880100
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.70899747
31CBP_20019798_ChIP-Seq_JUKART_Human1.69786100
32IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.69786100
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.69315757
34AR_21572438_ChIP-Seq_LNCaP_Human1.66743852
35UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.64475183
36SMAD4_21799915_ChIP-Seq_A2780_Human1.63074994
37POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.59970126
38TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59970126
39TCF4_23295773_ChIP-Seq_U87_Human1.58631048
40MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.57682777
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57195683
42PCGF2_27294783_Chip-Seq_NPCs_Mouse1.57004862
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55342181
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54583444
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.48146569
46BCAT_22108803_ChIP-Seq_LS180_Human1.40848777
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.40186441
48AR_25329375_ChIP-Seq_VCAP_Human1.38895258
49NFE2_27457419_Chip-Seq_LIVER_Mouse1.38406494
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36849288
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36056512
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35101401
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33101486
54PRDM14_20953172_ChIP-Seq_ESCs_Human1.31726492
55TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.30540836
56CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.30257825
57FLI1_21867929_ChIP-Seq_TH2_Mouse1.29944016
58TCF4_22108803_ChIP-Seq_LS180_Human1.29773575
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.29196438
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.28083248
61TP53_22573176_ChIP-Seq_HFKS_Human1.26175665
62* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25172062
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24660788
64TP53_16413492_ChIP-PET_HCT116_Human1.24326255
65HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24113364
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23946261
67RUNX2_22187159_ChIP-Seq_PCA_Human1.23554548
68KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22739670
69NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21595192
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.20416442
71TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17784630
72EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14490990
73CRX_20693478_ChIP-Seq_RETINA_Mouse1.12769127
74GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12755151
75SMAD4_21741376_ChIP-Seq_EPCs_Human1.11764762
76OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10251089
77E2F1_18555785_Chip-Seq_ESCs_Mouse1.09535726
78CDX2_22108803_ChIP-Seq_LS180_Human1.07482402
79P53_22387025_ChIP-Seq_ESCs_Mouse1.07359440
80SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04831534
81CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.03960678
82ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03115001
83SOX2_19829295_ChIP-Seq_ESCs_Human1.02289453
84NANOG_19829295_ChIP-Seq_ESCs_Human1.02289453
85TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01864161
86TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01398624
87P300_18555785_Chip-Seq_ESCs_Mouse1.00210919
88SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.98713804
89HOXB7_26014856_ChIP-Seq_BT474_Human0.98705817
90GATA3_26560356_Chip-Seq_TH2_Human0.98369095
91MYC_18940864_ChIP-ChIP_HL60_Human0.98302233
92EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97930862
93REST_21632747_ChIP-Seq_MESCs_Mouse0.97260683
94PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97090935
95SMAD_19615063_ChIP-ChIP_OVARY_Human0.96043271
96CMYC_18555785_Chip-Seq_ESCs_Mouse0.95618768
97EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.95574397
98KDM2B_26808549_Chip-Seq_REH_Human0.94155152
99STAT3_18555785_Chip-Seq_ESCs_Mouse0.93691401
100SOX2_21211035_ChIP-Seq_LN229_Gbm0.93468131

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.23421683
2MP0008877_abnormal_DNA_methylation3.95408439
3MP0003787_abnormal_imprinting3.92823111
4MP0003646_muscle_fatigue3.19207141
5MP0008057_abnormal_DNA_replication2.92895218
6MP0002102_abnormal_ear_morphology2.71136816
7MP0003195_calcinosis2.17678866
8MP0000427_abnormal_hair_cycle2.15268673
9MP0005310_abnormal_salivary_gland2.06291029
10MP0005551_abnormal_eye_electrophysiolog2.03589508
11MP0000015_abnormal_ear_pigmentation1.91644144
12MP0005174_abnormal_tail_pigmentation1.89723396
13MP0003136_yellow_coat_color1.83155491
14MP0002006_tumorigenesis1.82399364
15MP0004142_abnormal_muscle_tone1.81346144
16MP0003890_abnormal_embryonic-extraembry1.81022222
17MP0002638_abnormal_pupillary_reflex1.75824509
18MP0005253_abnormal_eye_physiology1.67317948
19MP0006072_abnormal_retinal_apoptosis1.57559512
20MP0004381_abnormal_hair_follicle1.55767324
21MP0005645_abnormal_hypothalamus_physiol1.53722304
22MP0000372_irregular_coat_pigmentation1.45610850
23MP0003880_abnormal_central_pattern1.45082291
24MP0008872_abnormal_physiological_respon1.43965770
25MP0003121_genomic_imprinting1.42230526
26MP0004885_abnormal_endolymph1.38588903
27MP0006276_abnormal_autonomic_nervous1.36324788
28MP0009046_muscle_twitch1.35939094
29MP0006292_abnormal_olfactory_placode1.30211760
30MP0004130_abnormal_muscle_cell1.26606208
31MP0002837_dystrophic_cardiac_calcinosis1.24839446
32MP0000631_abnormal_neuroendocrine_gland1.24587816
33MP0008995_early_reproductive_senescence1.22080765
34MP0001486_abnormal_startle_reflex1.21382749
35MP0002928_abnormal_bile_duct1.21124677
36MP0002653_abnormal_ependyma_morphology1.18258375
37MP0001986_abnormal_taste_sensitivity1.18117404
38MP0001485_abnormal_pinna_reflex1.17229263
39MP0000778_abnormal_nervous_system1.16999317
40MP0005671_abnormal_response_to1.16988766
41MP0009745_abnormal_behavioral_response1.16815029
42MP0002138_abnormal_hepatobiliary_system1.15151749
43MP0005075_abnormal_melanosome_morpholog1.13772612
44MP0002160_abnormal_reproductive_system1.12794677
45MP0001968_abnormal_touch/_nociception1.11023809
46MP0002009_preneoplasia1.10721961
47MP0001919_abnormal_reproductive_system1.10435380
48MP0001501_abnormal_sleep_pattern1.09973636
49MP0003763_abnormal_thymus_physiology1.06966077
50MP0005389_reproductive_system_phenotype1.04135304
51MP0000383_abnormal_hair_follicle1.03751922
52MP0002272_abnormal_nervous_system1.01669305
53MP0001984_abnormal_olfaction1.01533437
54MP0001800_abnormal_humoral_immune1.00525495
55MP0005187_abnormal_penis_morphology1.00179978
56MP0003252_abnormal_bile_duct0.99178214
57MP0002572_abnormal_emotion/affect_behav0.96754567
58MP0004742_abnormal_vestibular_system0.96719651
59MP0002557_abnormal_social/conspecific_i0.96352771
60MP0002095_abnormal_skin_pigmentation0.93759065
61MP0000613_abnormal_salivary_gland0.92693574
62MP0004043_abnormal_pH_regulation0.91971042
63MP0004924_abnormal_behavior0.90298213
64MP0005386_behavior/neurological_phenoty0.90298213
65MP0002067_abnormal_sensory_capabilities0.90263601
66MP0002063_abnormal_learning/memory/cond0.90188716
67MP0002751_abnormal_autonomic_nervous0.90022072
68MP0001835_abnormal_antigen_presentation0.88030791
69MP0000371_diluted_coat_color0.86470183
70MP0000647_abnormal_sebaceous_gland0.83690790
71MP0005195_abnormal_posterior_eye0.83377887
72MP0008058_abnormal_DNA_repair0.82305072
73MP0005646_abnormal_pituitary_gland0.81560709
74MP0003122_maternal_imprinting0.81011084
75MP0002876_abnormal_thyroid_physiology0.79295820
76MP0004147_increased_porphyrin_level0.75690480
77MP0006035_abnormal_mitochondrial_morpho0.75192602
78MP0002752_abnormal_somatic_nervous0.74533669
79MP0005647_abnormal_sex_gland0.74408929
80MP0004484_altered_response_of0.73944305
81MP0005085_abnormal_gallbladder_physiolo0.73170934
82MP0000689_abnormal_spleen_morphology0.72935723
83MP0001502_abnormal_circadian_rhythm0.72715474
84MP0002723_abnormal_immune_serum0.71962438
85MP0002909_abnormal_adrenal_gland0.71804321
86MP0002735_abnormal_chemical_nociception0.70951102
87MP0003635_abnormal_synaptic_transmissio0.70349444
88MP0000955_abnormal_spinal_cord0.69708948
89MP0001440_abnormal_grooming_behavior0.69361735
90MP0002229_neurodegeneration0.68342831
91MP0001293_anophthalmia0.68045086
92MP0003866_abnormal_defecation0.68021941
93MP0005084_abnormal_gallbladder_morpholo0.67796388
94MP0004145_abnormal_muscle_electrophysio0.67793104
95MP0001324_abnormal_eye_pigmentation0.67687125
96MP0003943_abnormal_hepatobiliary_system0.67600377
97MP0002736_abnormal_nociception_after0.67157810
98MP0005391_vision/eye_phenotype0.66806520
99MP0004133_heterotaxia0.66579798
100MP0008875_abnormal_xenobiotic_pharmacok0.66252824

Predicted human phenotypes

RankGene SetZ-score
1Optic neuritis (HP:0100653)4.23218909
2Retrobulbar optic neuritis (HP:0100654)4.23218909
3Pancreatic cysts (HP:0001737)3.79349104
4Chronic hepatic failure (HP:0100626)3.66623813
5Congenital stationary night blindness (HP:0007642)3.56780372
6Orchitis (HP:0100796)3.43824841
7Abnormality of the labia minora (HP:0012880)3.31728458
8Pancreatic fibrosis (HP:0100732)3.31276601
9Gaze-evoked nystagmus (HP:0000640)3.06795907
10Nephronophthisis (HP:0000090)3.01438617
11Abnormality of the renal cortex (HP:0011035)2.99462892
12Abnormality of midbrain morphology (HP:0002418)2.99112063
13Molar tooth sign on MRI (HP:0002419)2.99112063
14True hermaphroditism (HP:0010459)2.97446048
15Abnormality of the renal medulla (HP:0100957)2.89652328
16Myositis (HP:0100614)2.87504129
17Hyperventilation (HP:0002883)2.81729050
18Progressive inability to walk (HP:0002505)2.78707081
19Genetic anticipation (HP:0003743)2.76495861
20Thyroiditis (HP:0100646)2.72551360
21Keratoconjunctivitis (HP:0001096)2.67737962
22Keratoconjunctivitis sicca (HP:0001097)2.66856069
23Progressive cerebellar ataxia (HP:0002073)2.66312794
24Fair hair (HP:0002286)2.62164990
25Abnormal hair whorl (HP:0010721)2.58078985
26Medial flaring of the eyebrow (HP:0010747)2.49603466
27Protruding tongue (HP:0010808)2.47068526
28Tubular atrophy (HP:0000092)2.46105149
29Inability to walk (HP:0002540)2.42292059
30Abnormal rod and cone electroretinograms (HP:0008323)2.38817986
31Nephrogenic diabetes insipidus (HP:0009806)2.31704980
32Hip dysplasia (HP:0001385)2.28816208
33Lissencephaly (HP:0001339)2.27186850
34Absent rod-and cone-mediated responses on ERG (HP:0007688)2.26193245
35Abnormal delayed hypersensitivity skin test (HP:0002963)2.23529238
36Hypoplastic ischia (HP:0003175)2.22905112
37Gait imbalance (HP:0002141)2.19671209
38Panhypogammaglobulinemia (HP:0003139)2.17626119
39Congenital primary aphakia (HP:0007707)2.11364680
40Type II lissencephaly (HP:0007260)2.11156995
41Abolished electroretinogram (ERG) (HP:0000550)2.09350643
42Absent speech (HP:0001344)2.07702050
43Broad-based gait (HP:0002136)2.06080570
44Renal cortical cysts (HP:0000803)2.05313504
45Cystic liver disease (HP:0006706)2.03813744
46Generalized hypopigmentation of hair (HP:0011358)2.02676751
47Intestinal atresia (HP:0011100)2.02463983
48Febrile seizures (HP:0002373)2.02097782
49Abnormality of DNA repair (HP:0003254)2.01786692
50Attenuation of retinal blood vessels (HP:0007843)1.99382065
51Abnormality of the ischium (HP:0003174)1.97313264
52Severe combined immunodeficiency (HP:0004430)1.95172618
53Poor coordination (HP:0002370)1.95156668
54Chronic mucocutaneous candidiasis (HP:0002728)1.94567205
55Recurrent cutaneous fungal infections (HP:0011370)1.94567205
56Drooling (HP:0002307)1.92766282
57Genital tract atresia (HP:0001827)1.89864508
58Prominent nose (HP:0000448)1.89270903
59Elevated erythrocyte sedimentation rate (HP:0003565)1.89244282
60Cerebellar dysplasia (HP:0007033)1.88533141
61Widely spaced teeth (HP:0000687)1.87896225
62Large for gestational age (HP:0001520)1.87853727
63Stomach cancer (HP:0012126)1.87623167
64Agitation (HP:0000713)1.87519655
65Anencephaly (HP:0002323)1.87463214
66Keratitis (HP:0000491)1.86929464
67Vaginal atresia (HP:0000148)1.86756546
68T lymphocytopenia (HP:0005403)1.86602953
69IgG deficiency (HP:0004315)1.86345534
70Encephalitis (HP:0002383)1.85042303
71Sloping forehead (HP:0000340)1.83914711
72Hemoptysis (HP:0002105)1.83626817
73Cutaneous melanoma (HP:0012056)1.83201018
74Volvulus (HP:0002580)1.81640542
75Pendular nystagmus (HP:0012043)1.80505080
76Abnormal biliary tract physiology (HP:0012439)1.80342186
77Bile duct proliferation (HP:0001408)1.80342186
78Abnormality of T cell number (HP:0011839)1.79201508
79Abnormal pancreas size (HP:0012094)1.79138096
80Impaired smooth pursuit (HP:0007772)1.78925423
81Truncal obesity (HP:0001956)1.78696399
82Excessive salivation (HP:0003781)1.78696398
83Neoplasm of the adrenal cortex (HP:0100641)1.77318714
84Tubulointerstitial nephritis (HP:0001970)1.76975157
85Congenital hepatic fibrosis (HP:0002612)1.76299646
86Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.74058441
87Hemiparesis (HP:0001269)1.73302554
88Chorioretinal atrophy (HP:0000533)1.72537913
89Ectopic kidney (HP:0000086)1.72521663
90Aplasia/Hypoplasia of the tibia (HP:0005772)1.72485650
91Tented upper lip vermilion (HP:0010804)1.71325625
92Clumsiness (HP:0002312)1.70440915
93Abnormality of eosinophils (HP:0001879)1.69985341
94Pachygyria (HP:0001302)1.68955490
95Postaxial foot polydactyly (HP:0001830)1.68093842
96Abnormal drinking behavior (HP:0030082)1.67945171
97Polydipsia (HP:0001959)1.67945171
98Optic nerve hypoplasia (HP:0000609)1.67386437
99Hypoproteinemia (HP:0003075)1.65776444
100Patellar aplasia (HP:0006443)1.64320586

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.16042311
2WNK33.06261554
3ACVR1B2.55851431
4NUAK12.54413666
5MAP3K42.39733031
6TXK2.28973615
7TLK12.25578960
8EPHA32.18593590
9BMPR1B2.05370369
10ADRBK21.93008305
11NEK91.92499413
12TAOK31.82322337
13MAP4K21.63123483
14NLK1.59449465
15ZAK1.55380280
16BRD41.50974445
17SGK21.49501732
18MKNK21.46415468
19MAPK131.45360738
20LATS11.44690569
21BRSK21.35775965
22TNIK1.34745000
23CASK1.34635648
24PINK11.34405117
25AKT31.32195968
26PAK31.30664764
27GRK11.24535198
28WNK41.22106287
29CAMKK21.16575168
30OXSR11.15717008
31INSRR1.13217699
32EIF2AK31.02676099
33BCR1.02080796
34PIK3CA1.00001721
35SIK20.99674476
36MAP2K70.98797899
37FER0.95383283
38SGK4940.94928519
39SGK2230.94928519
40MARK10.93002058
41TNK20.87362413
42MARK30.87292838
43BTK0.86969929
44TEC0.85491915
45TRIM280.84581298
46PIK3CG0.84568779
47YES10.84119119
48IRAK10.83660006
49STK390.83466044
50STK38L0.83223291
51SGK30.81020600
52SRPK10.80754948
53ERBB30.80472198
54GRK70.80293919
55FGFR20.78292610
56CSNK1G20.75754072
57DAPK20.74518767
58SYK0.74198884
59MAP2K40.70920534
60STK110.69464757
61NEK20.69390515
62PRKCQ0.67355355
63CSNK1A1L0.66267736
64PRKAA20.66095664
65PRKCE0.66071165
66ATR0.61980456
67CAMK1G0.61549481
68JAK30.60148138
69DYRK1B0.59649403
70JAK10.59625131
71ITK0.59096758
72DYRK1A0.56713023
73PLK20.56514498
74LCK0.55859835
75CAMK1D0.55444854
76PIM10.54744839
77MKNK10.54147963
78KIT0.53077975
79NTRK30.52848814
80RPS6KA50.52709932
81FGFR30.52408762
82ATM0.52399155
83OBSCN0.51434372
84CSNK1D0.50587326
85CSNK1G10.50492161
86WNK10.50031322
87DYRK20.49879807
88CAMK40.49722918
89MST40.47648163
90CHUK0.46982403
91FES0.45959637
92STK30.44525308
93RPS6KA40.42796330
94PRKAA10.42782929
95MAP3K70.41903328
96IKBKE0.41851675
97LYN0.41667883
98PRKCG0.41280659
99IKBKB0.41172811
100JAK20.39677690

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034502.36495802
2Phototransduction_Homo sapiens_hsa047442.31603313
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.22450930
4Fanconi anemia pathway_Homo sapiens_hsa034602.17051074
5Primary immunodeficiency_Homo sapiens_hsa053402.15854551
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.10833655
7Selenocompound metabolism_Homo sapiens_hsa004502.08952931
8Basal transcription factors_Homo sapiens_hsa030221.97590778
9Linoleic acid metabolism_Homo sapiens_hsa005911.92907883
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.91591020
11Homologous recombination_Homo sapiens_hsa034401.88342795
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.86113080
13Nitrogen metabolism_Homo sapiens_hsa009101.81846132
14Ether lipid metabolism_Homo sapiens_hsa005651.81272588
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.78033454
16Nicotine addiction_Homo sapiens_hsa050331.77540598
17Dorso-ventral axis formation_Homo sapiens_hsa043201.77408603
18Circadian rhythm_Homo sapiens_hsa047101.77304173
19Butanoate metabolism_Homo sapiens_hsa006501.75798945
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.64463760
21Jak-STAT signaling pathway_Homo sapiens_hsa046301.63527901
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.59965839
23Regulation of autophagy_Homo sapiens_hsa041401.55637344
24Caffeine metabolism_Homo sapiens_hsa002321.53101527
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48954523
26RNA degradation_Homo sapiens_hsa030181.48096280
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45151162
28Taste transduction_Homo sapiens_hsa047421.42156617
29Lysine degradation_Homo sapiens_hsa003101.37445349
30ABC transporters_Homo sapiens_hsa020101.34601691
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.25952696
32Propanoate metabolism_Homo sapiens_hsa006401.20702633
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.20451911
34T cell receptor signaling pathway_Homo sapiens_hsa046601.17821979
35Olfactory transduction_Homo sapiens_hsa047401.17013308
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.14600623
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11641397
38Morphine addiction_Homo sapiens_hsa050321.11074525
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09718649
40RNA polymerase_Homo sapiens_hsa030201.04710670
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01663885
42Primary bile acid biosynthesis_Homo sapiens_hsa001200.95508517
43Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.94696154
44Intestinal immune network for IgA production_Homo sapiens_hsa046720.94574543
45Glutamatergic synapse_Homo sapiens_hsa047240.90328695
46GABAergic synapse_Homo sapiens_hsa047270.89986120
47FoxO signaling pathway_Homo sapiens_hsa040680.87083004
48Tryptophan metabolism_Homo sapiens_hsa003800.87025633
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81251984
50Serotonergic synapse_Homo sapiens_hsa047260.80765043
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80047671
52Inositol phosphate metabolism_Homo sapiens_hsa005620.79631961
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.79075206
54Antigen processing and presentation_Homo sapiens_hsa046120.77808819
55Long-term depression_Homo sapiens_hsa047300.77030921
56Ovarian steroidogenesis_Homo sapiens_hsa049130.76998754
57Peroxisome_Homo sapiens_hsa041460.75389615
58Insulin secretion_Homo sapiens_hsa049110.74613763
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73172168
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72914240
61Circadian entrainment_Homo sapiens_hsa047130.70356692
62One carbon pool by folate_Homo sapiens_hsa006700.70162506
63Measles_Homo sapiens_hsa051620.70137719
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66543155
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65442356
66Dopaminergic synapse_Homo sapiens_hsa047280.64419614
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62857261
68Prolactin signaling pathway_Homo sapiens_hsa049170.62577637
69Cholinergic synapse_Homo sapiens_hsa047250.61766051
70Chemokine signaling pathway_Homo sapiens_hsa040620.61503092
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.60480961
72Calcium signaling pathway_Homo sapiens_hsa040200.56503740
73p53 signaling pathway_Homo sapiens_hsa041150.56403477
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55330922
75Oxytocin signaling pathway_Homo sapiens_hsa049210.55043177
76NF-kappa B signaling pathway_Homo sapiens_hsa040640.54695300
77Type II diabetes mellitus_Homo sapiens_hsa049300.54307210
78Protein export_Homo sapiens_hsa030600.54230600
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52691432
80cAMP signaling pathway_Homo sapiens_hsa040240.52414921
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50380356
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49656924
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49583673
84Graft-versus-host disease_Homo sapiens_hsa053320.47299626
85MAPK signaling pathway_Homo sapiens_hsa040100.46704625
86Steroid biosynthesis_Homo sapiens_hsa001000.45085803
87Glycerolipid metabolism_Homo sapiens_hsa005610.43577929
88Salivary secretion_Homo sapiens_hsa049700.43088100
89Retinol metabolism_Homo sapiens_hsa008300.41817089
90Arachidonic acid metabolism_Homo sapiens_hsa005900.40562647
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39673760
92Type I diabetes mellitus_Homo sapiens_hsa049400.37758021
93mTOR signaling pathway_Homo sapiens_hsa041500.37488899
94Ras signaling pathway_Homo sapiens_hsa040140.37325476
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36545668
96Hematopoietic cell lineage_Homo sapiens_hsa046400.36189028
97Insulin resistance_Homo sapiens_hsa049310.36184785
98Choline metabolism in cancer_Homo sapiens_hsa052310.34785991
99ErbB signaling pathway_Homo sapiens_hsa040120.32674052
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.32549867

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